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JOURNAL ARTICLE
Parker J Nichols, Robb Welty, Jeffrey B Krall, Morkos A Henen, Quentin Vicens, Beat Vögeli
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA when bound by Zα domains found within a variety of viral and innate immune response proteins. While Z-form adoption is preferred by certain sequences, such as the commonly studied (CpG)n repeats, Zα has been reported to bind to a wide range of sequence contexts. Studying how Zα interacts with B-/A-form helices prior to their conversion to the Z-conformation is challenging as binding coincides with Z-form adoption...
March 4, 2024: Biochemistry
#22
Victor H Molina-Lopez, Ismael Ortiz-Cartagena, Josue Mercado-Crespo, Miguel A Campos-Esteve
Transcatheter aortic valve replacement (TAVR) has increasingly become a fundamental approach for treating aortic valve stenosis (AVS), especially in high surgical risk patients. This case study underscores the criticality of meticulous procedural planning and precise valve selection in patients with severe AVS compounded by obesity. We report a case of a patient who, after receiving a 26 mm Edwards Sapiens 3 valve, presented with worsening exertional dyspnea and a declining indexed effective orifice area (EOAi)...
January 2024: Curēus
#23
Heberto Aquino-Bruno, Roberto Muratalla-González, Juan F Garcia-Garcia, José L Triano-Doroteo, Kevin Felix Rivera, Gerardo Carreon Balcarcel, Marisol Navarrete-Osuna
BACKGROUND: The presence of severe aortic stenosis in quadricuspid aortic valve (QAV) is an extremely rare combination, and it is unknown whether transcatheter aortic valve replacement (TAVR) is a safe option due to the low incidence. CASE SUMMARY: We present two patients diagnosed with severe aortic stenosis with QAV morphology type 1 (Nakamura classification). All patients presented to our hospital for evaluation because of worsening functional class, dyspnoea, or syncope...
February 2024: European Heart Journal. Case Reports
#24
JOURNAL ARTICLE
Marianna Adamo, Luca Branca, Elisa Pezzola, Francesco Saia, Thomas Pilgrim, Mohamed Abdel-Wahab, Philippe Garot, Caterina Gandolfo, Claudia Fiorina, Sofia Sammartino, Azeem Latib, Ignacio Amat Santos, Darren Mylotte, Federico De Marco, Ole De Backer, Luis Nombela Franco, Mariama Akodad, Flavio Luciano Ribichini, Francesco Bedogni, Giulia Laterra, Alessandro Mazzapicchi, Daijiro Tomii, Pietro Laforgia, Stefano Cannata, Andrea Scotti, Simone Fezzi, Enrico Criscione, Enrico Poletti, Mattia Mazzucca, Roberto Valvo, MattiaLunardi, Andrea Mainardi, Stefano Andreaggi, Angelo Quagliana, Nicholas Montarello, Breda Hennessey, Matias Mon-Noboa, David Meier, Carmelo Sgroi, Claudia Maria Reddavid, Orazio Strazzieri, Silvia Crescenzia Motta, Valentina Frittitta, Elena Dipietro, Alessandro Comis, Chiara Melfa, Mariachiara Calì, Holger Thiele, John G Webb, Lars Sondergaard, Corrado Tamburino, Marco Metra, Giuliano Costa, Marco Barbanti
Evidence regarding sex-related differences in response to transcatheter aortic valve implantation according to the valve type is lacking. This study sought to evaluate the impact of sex on the treatment effect of Evolut-PRO/PRO+ (PRO) or Sapien 3 Ultra (ULTRA) devices on clinical outcomes. Comparative Analysis of Evolut PRO vs Sapien 3 Ultra Valves for Transfemoral Transcatheter Aortic Valve Implantation (OPERA-TAVI) is a multicenter multinational registry including patients undergoing latest-iteration PRO or ULTRA implantation...
February 22, 2024: American Journal of Cardiology
#25
JOURNAL ARTICLE
Syeda A Hasan, Moustafa Morsi, Belinda S Frakes, Marien E Bryson, Christian W Schmidt, Puvi Seshiah, Joseph Choo, J Michael Smith, Geoffrey A Answini, Terri L Stewart-Dehner, Senan J Yasar, James G Jollis, Mark D Berlacher, Teresa M Ratajczak, Eugene S Chung, Dean J Kereiakes, Santiago Garcia
BACKGROUND: Transcatheter mitral valve replacement (TMVR) faces anatomical challenges, currently limiting widespread adoption. OBJECTIVES: To describe the natural history and prognosis of patients ineligible for various TMVR devices. METHODS: During a 4-year period (2019-2023) 3 TMVR devices (SAPIEN M3, Intrepid and Alta Valve) became available at a single institution (The Christ Hospital, Cincinnati, OH) in the setting of pivotal clinical trials or early feasibility study...
February 10, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#26
JOURNAL ARTICLE
Guadalupe Romero Villanueva, Marcela Sepúlveda, José Cárcamo-Vega, Alexander Cherkinsky, María Eugenia de Porras, Ramiro Barberena
The timing for the evolution of the capacity to inscribe the landscape with rock art has global relevance. While this was an in-built capacity when Homo sapiens first colonized the Americas, the heterogeneous distribution of rock art shows that it was a facultative behavior arising under unknown socioecological conditions. Patagonia was the last region to be explored by humans. While its rock art is globally important, it remains largely undated by absolute methods. We report the earliest set of directly radiocarbon-dated rock art motifs from the archaeological site Cueva Huenul 1 (northwestern Patagonia, Argentina), starting at 8...
February 16, 2024: Science Advances
#27
JOURNAL ARTICLE
Melchor González-Dávila, Maria T Maldonado, Aridane G González, Jian Guo, David González-Santana, Antera Martel, J Magdalena Santana-Casiano
Elucidating whether dissolved Cu uptake is kinetically or thermodynamically controlled, and the effects of speciation on Cu transport by phytoplankton will allow better modeling of the fate and impact of dissolved Cu in the ocean. To address these questions, we performed Cu physiological and physicochemical experiments using the model diatom, Phaeodactylum tricornutum, grown in natural North Atlantic seawater (0.44 nM Cu). Using competitive ligand equilibration-cathodic stripping voltammetry (CLE-CSV), we measured two organic ligand types released by P...
February 8, 2024: Science of the Total Environment
#28
JOURNAL ARTICLE
Wissam Harmouch, Barbara Karnkowska, Ravi Thakker, Peter Rasmussen, Mostafa Shalaby, Wissam Khalife, Haider Alwash, Afaq Motiwala, Paul Kumfa, Syed Gilani, Hani Jneid, Umamahesh Rangasetty
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) plays a vital role in patients with symptomatic aortic stenosis. Despite the mortality benefit of TAVI, embolic stroke remains a feared complication. As a result, transcatheter cerebral embolic protection (TCEP) devices have been developed to reduce this risk. Given the ongoing debate of TCEP in TAVI, we performed a systematic review and meta-analysis of all randomized controlled trials to date to identify outcomes of periprocedural stroke using the Sentinel™ cerebral protection system (CPS)...
February 10, 2024: Cardiology and Therapy
#29
JOURNAL ARTICLE
Brennan J Vogl, Alejandra Chavez-Ponce, Adam Wentworth, Eric Erie, Pradeep Yadav, Vinod H Thourani, Lakshmi Prasad Dasi, Brian Lindman, Mohamad Alkhouli, Hoda Hatoum
BACKGROUND: The cause for the association between increased cardiovascular mortality rates and lower blood pressure (BP) after aortic valve replacement (AVR) is unclear. This study aims to assess how the epicardial coronary flow (ECF) after AVR varies as BP levels are changed in the presence of a right coronary lesion. METHODS: The hemodynamics of a 3D printed aortic root model with a SAPIEN 3 26 deployed were evaluated in an in vitro left heart simulator under a range of varying systolic blood pressure (SBP) and diastolic blood pressure (DBP)...
January 2024: Structural heart: the journal of the Heart Team
#30
JOURNAL ARTICLE
Rayan S El-Zein, Ali O Malik, David J Cohen, John A Spertus, John T Saxon, Philippe Pibarot, Rebecca T Hahn, Maria C Alu, Kan Shang, Susheel K Kodali, Vinod H Thourani, Martin B Leon, Michael J Mack, Adnan K Chhatriwalla
BACKGROUND: Baseline left ventricular diastolic dysfunction (LVDD) is associated with poor health status in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR), but health status improvement after TAVR appears similar across all grades of LVDD. Here, we aim to examine the relationship between changes in LVDD severity and health status outcomes following TAVR. METHODS: Patients who underwent TAVR and had evaluable LVDD at both baseline and 1 year in the PARTNER (Placement of Aortic Transcatheter Valves) 2 SAPIEN 3 registries and PARTNER 3 trial were analyzed...
January 2024: Structural heart: the journal of the Heart Team
#31
JOURNAL ARTICLE
Chen Ye, Qi Wu, Shuxia Chen, Xuemei Zhang, Wenwen Xu, Yunzhi Wu, Youhua Zhang, Yi Yue
BACKGROUND: In cellular activities, essential proteins play a vital role and are instrumental in comprehending fundamental biological necessities and identifying pathogenic genes. Current deep learning approaches for predicting essential proteins underutilize the potential of gene expression data and are inadequate for the exploration of dynamic networks with limited evaluation across diverse species. RESULTS: We introduce ECDEP, an essential protein identification model based on evolutionary community discovery...
January 26, 2024: BMC Genomics
#32
JOURNAL ARTICLE
Alexander C Egbe, Abdalla A Salama, William R Miranda, Snigdha Karnakoti, Jason H Anderson, C Charles Jain, Luke J Burchill, Heidi M Connolly
BACKGROUND: There are limited data about postprocedural right heart reverse remodeling and long-term prosthesis durability after transcatheter pulmonary valve replacement (TPVR) and how these compare to surgical pulmonary valve replacement (SPVR). OBJECTIVES: This study sought to compare right heart reverse remodeling, pulmonary valve gradients, and prosthetic valve dysfunction after TPVR vs SPVR. METHODS: Patients with TPVR were matched 1:2 to patients with SPVR based on age, sex, body surface area, congenital heart lesion, and procedure year...
January 22, 2024: JACC. Cardiovascular Interventions
#33
JOURNAL ARTICLE
Ada C Stefanescu Schmidt, Aimee K Armstrong, Jamil A Aboulhosn, Kevin F Kennedy, Thomas K Jones, Daniel S Levi, Doff B McElhinney, Ami B Bhatt
BACKGROUND: Transcatheter pulmonary valve replacement (TPVR) has expanded and evolved since its initial commercial approval in the United States in 2010. OBJECTIVES: This study sought to characterize real-world practice, including patient selection, procedural outcomes, complications, and off-label usage. METHODS: Characteristics and outcomes for patients undergoing balloon-expandable TPVR were collected from the American College of Cardiology National Cardiovascular Data Registry IMPACT (Improving Pediatric and Adult Congenital Treatment) Registry...
January 22, 2024: JACC. Cardiovascular Interventions
#34
JOURNAL ARTICLE
Mouncef Sedrati, Juan A Morales, Jérémy Duveau, Abdelmounim El M'rini, Eduardo Mayoral, Ignacio Díaz-Martínez, Edward J Anthony, Glen Bulot, Anass Sedrati, Romain Le Gall, Ana Santos, Jorge Rivera-Silva
Footprints represent a relevant vestige providing direct information on the biology, locomotion, and behaviour of the individuals who left them. However, the spatiotemporal distribution of hominin footprints is heterogeneous, particularly in North Africa, where no footprint sites were known before the Holocene. This region is important in the evolution of hominins. It notably includes the earliest currently known Homo sapiens (Jebel Irhoud) and the oldest and richest African Middle Stone Age hominin sites. In this fragmented ichnological record, we report the discovery of 85 human footprints on a Late Pleistocene now indurated beach surface of about 2800 m2 at Larache (Northwest coast of Morocco)...
January 23, 2024: Scientific Reports
#35
JOURNAL ARTICLE
Jian Tang, Yanhong Tang, Peimin Lin, Jie Zheng, Zhengfen Li, Ying Zhang
OBJECTIVE: In the quest to decipher the molecular intricacies of Postoperative Cognitive Dysfunction (POCD), this study focused on circular RNA (circRNA) and their regulatory networks. MATERIALS AND METHODS: Analyzing the Gene Expression Omnibus Series (GSE)147277 dataset, we pinpointed 10 differentially expressed circRNAs linked to POCD. RESULTS: The ensuing competing endogenous RNA (ceRNA) network, featuring pivotal players like Homo sapiens(hsa)_circ_0003424 and hsa-miR-193b-5p, provided a comprehensive understanding of the molecular players at play in POCD...
January 23, 2024: International Journal of Neuroscience
#36
Abderrahim Sanoussi, Adel Aminian, Jâd Abi-Khalil
The management of patients with severe aortic valve stenosis and an abdominal aortic aneurysm is a real therapeutic challenge. Minimally invasive treatment is more beneficial than open surgery for treating both aortic valve stenosis and abdominal aortic aneurysm. We present a case of a 77-year-old male initially treated with a 26 mm Sapien 3 transcatheter aortic valve replacement. Subsequently, using the same femoral access points, a custom fenestrated endoprosthesis and stents in digestive trunks and renal arteries were implanted...
March 2024: Radiology Case Reports
#37
JOURNAL ARTICLE
Nidal Jammoul, Valentin Dupasquier, Mariama Akodad, Pierre-Alain Meunier, Lionel Moulis, Sonia Soltani, Jean-Christophe Macia, Pierre Robert, Laurent Schmutz, Matthieu Steinecker, Christophe Piot, Frederic Targosz, Henri Benkemoun, Benoît Lattuca, François Roubille, Guillaume Cayla, Florence Leclercq
BACKGROUND: Safety and feasibility of transcatheter aortic valve replacement (TAVR) without balloon aortic valvuloplasty (BAV) using the SAPIEN 3 balloon-expandable device has been previously demonstrated. The impact on long-term valve hemodynamic performances and outcomes remains however unknown. We evaluate long-term clinical and hemodynamic results according to the implant strategy (direct TAVR versus BAV pre TAVR) in patients included in the DIRECTAVI randomized trial (NCT02729519)...
January 20, 2024: American Heart Journal
#38
JOURNAL ARTICLE
Hiroki A Ueyama, Adam B Greenbaum, Joe X Xie, Nikoloz Shekiladze, Patrick T Gleason, Isida Byku, Chandan M Devireddy, George S Hanzel, Peter C Block, Vasilis C Babaliaros
BACKGROUND: Transcatheter closure of transcatheter heart valve (THV)-related paravalvular leak (PVL) is associated with a high failure rate with available devices due to the complex interaction of THV and aortic/mitral annulus. OBJECTIVES: This study reports novel transcatheter techniques to treat PVL after THV. METHODS: We describe consecutive patients who underwent PVL closure after transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR)...
January 9, 2024: JACC. Cardiovascular Interventions
#39
JOURNAL ARTICLE
Norihisa Miyawaki, Kenichi Ishizu, Shinichi Shirai, Kenji Nakano, Tadatomo Fukushima, Euihong Ko, Yasuo Tsuru, Hiroaki Tashiro, Miho Nakamura, Hiroyuki Tabata, Toru Morofuji, Takashi Morinaga, Masaomi Hayashi, Akihiro Isotani, Nobuhisa Ohno, Shinichi Kakumoto, Kenji Ando
BACKGROUND: In the Asian cohort, data are limited on the risk for coronary obstruction due to sinus of Valsalva (SOV) sequestration in redo transcatheter aortic valve replacement (TAVR) procedures. OBJECTIVES: The aim of this study was to assess the potential risk for coronary obstruction in simulated redo TAVR in Asian patients. METHODS: Post-TAVR computed tomographic data from 788 patients who received balloon-expandable (BE) SAPIEN 3 transcatheter aortic valves (TAVs) and 334 patients who received self-expanding (SE) Evolut R or Evolut PRO TAVs were analyzed...
January 2024: JACC Asia
#40
JOURNAL ARTICLE
Nathan El Bèze, Dominique Himbert, Gaspard Suc, Eric Brochet, Nadine Ajzenberg, Audrey Cailliau, John Kikoïne, Clemence Delhomme, Jose Luis Carrasco, Phalla Ou, Bernard Iung, Marina Urena
BACKGROUND: There is currently no established recommendation for antithrombotic treatment following transcatheter mitral valve replacement (TMVR). However, based on the analogy with surgical mitral bioprosthesis, vitamin K antagonists (VKAs) are predominantly used. OBJECTIVES: The purpose of this study was to compare bleeding and thrombotic events associated with direct oral anticoagulants (DOACs) or VKAs in a prospective cohort of TMVR patients. METHODS: We enrolled consecutive patients who underwent transseptal TMVR using a SAPIEN family prosthesis at our center between 2011 and 2023...
January 16, 2024: Journal of the American College of Cardiology
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