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Sapien 3

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https://www.readbyqxmd.com/read/27899140/transapical-transcatheter-aortic-valve-replacement-in-patients-with-or-without-prior-coronary-artery-bypass-graft-operation
#1
Konstantinos V Voudris, S Chiu Wong, Ryan Kaple, Polydoros N Kampaktsis, Andreas R de Biasi, Jonathan S Weiss, Richard Devereux, Karl Krieger, Luke Kim, Rajesh V Swaminathan, Dmitriy N Feldman, Harsimran Singh, Nikolaos J Skubas, Robert M Minutello, Geoffrey Bergman, Arash Salemi
BACKGROUND: Transapical approach (TA) is an established access alternative to the transfemoral technique in patients undergoing transcatheter aortic valve replacement (TAVR) for treatment of symptomatic aortic valve stenosis. The impact of prior coronary artery bypass grafting (CABG) on clinical outcomes in patients undergoing TA-TAVR is not well defined. METHODS: A single center retrospective cohort analysis of 126 patients (male 41%, mean age 85.8 ± 6.1 years) who underwent TA balloon expandable TAVR (Edwards SAPIEN, SAPIEN XT or SAPIEN 3) was performed...
November 29, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27899128/european-real-world-trans-catheter-aortic-valve-implantation-systematic-review-and-meta-analysis-of-european-national-registries
#2
REVIEW
G Krasopoulos, F Falconieri, U Benedetto, J Newton, R Sayeed, R Kharbanda, A Banning
OBJECTIVE: Transcatheter aortic valve implantation (TAVI) has been adopted rapidly in Europe. TAVI national registries can augment understanding of technologies and represent real-world experience, providing further clinical insights. We undertook a meta-analysis of published European national TAVI registries to assess current results following TAVI in Europe. METHODS: Electronic databases were searched. The review focused on the comparison of the following TAVI strategies: transfemoral (TF) and transapical (TA) SAPIEN and CoreValve implantation...
November 29, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27870342/the-mobility-of-the-human-face-more-than-just-the-musculature
#3
Anne M Burrows, Carolyn R Rogers-Vizena, Ly Li, Bryan Mendelson
The human face has the greatest mobility and facial display repertoire among all primates. However, the variables that account for this are not clear. Humans and other anthropoids have remarkably similar mimetic musculature. This suggests that differences among the mimetic muscles alone may not account for the increased mobility and facial display repertoire seen in humans. Furthermore, anthropoids themselves outpace prosimians in these categories: humans > other anthropoids > prosimians. This study was undertaken to clarify the morphological underpinnings of the increased mobility and display repertoire of the human face by investigating the SMAS (the superficial musculo-aponeurotic system), a connective tissue layer enclosing the mimetic musculature located between the skin and deep fascia/periosteum...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27864470/percutaneous-pulmonary-valve-implantation-in-the-native-right-ventricular-outflow-tract-using-a-29-mm-edwards-sapien-3-valve
#4
Patcharapong Suntharos, Lourdes R Prieto
Percutaneous pulmonary valve implantation is now an acceptable treatment option. The Edwards SAPIEN valve, intended for transcatheter aortic valve implantation, has been used in patients whose landing zone diameter is >22 to 24 mm which is not suitable for Melody valve. We report a patient in whom we successfully placed the latest generation, Edwards SAPIEN 3 (ES3) in the pulmonary position. However, because of the short covered portion of this valve, there was a significant paravalvular leak through the stent struts requiring implantation of a second ES3 valve...
November 18, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27856487/repositionable-versus-balloon-expandable-devices-for-transcatheter-aortic-valve-implantation-in-patients-with-aortic-stenosis
#5
Thomas Pilgrim, Stefan Stortecky, Fabian Nietlispach, Dik Heg, David Tueller, Stefan Toggweiler, Enrico Ferrari, Stéphane Noble, Francesco Maisano, Raban Jeger, Marco Roffi, Jürg Grünenfelder, Christoph Huber, Peter Wenaweser, Stephan Windecker
BACKGROUND: The safety and effectiveness of the fully repositionable LOTUS valve system as compared with the balloon-expandable Edwards SAPIEN 3 prosthesis for the treatment of aortic stenosis has not been evaluated to date. METHODS AND RESULTS: All patients undergoing transcatheter aortic valve implantation with the Edwards SAPIEN 3 or the LOTUS valve system were included into the Swiss Transcatheter Aortic Valve Implantation Registry. An adjusted analysis was performed to compare the early clinical safety outcome according to the Valve Academic Research Consortium-2 definition...
November 17, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27853608/fossil-skulls-reveal-that-blood-flow-rate-to-the-brain-increased-faster-than-brain-volume-during-human-evolution
#6
Roger S Seymour, Vanya Bosiocic, Edward P Snelling
The evolution of human cognition has been inferred from anthropological discoveries and estimates of brain size from fossil skulls. A more direct measure of cognition would be cerebral metabolic rate, which is proportional to cerebral blood flow rate (perfusion). The hominin cerebrum is supplied almost exclusively by the internal carotid arteries. The sizes of the foramina that transmitted these vessels in life can be measured in hominin fossil skulls and used to calculate cerebral perfusion rate. Perfusion in 11 species of hominin ancestors, from Australopithecus to archaic Homo sapiens, increases disproportionately when scaled against brain volume (the allometric exponent is 1...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27849158/neurological-injury-in-intermediate-risk-transcatheter-aortic-valve-implantation
#7
Jonathon P Fanning, Allan J Wesley, Darren L Walters, Eamonn M Eeles, Adrian G Barnett, David G Platts, Andrew J Clarke, Andrew A Wong, Wendy E Strugnell, Cliona O'Sullivan, Oystein Tronstad, John F Fraser
BACKGROUND: The application of transcatheter aortic valve implantation (TAVI) to intermediate-risk patients is a controversial issue. Of concern, neurological injury in this group remains poorly defined. Among high-risk and inoperable patients, subclinical injury is reported on average in 75% undergoing the procedure. Although this attendant risk may be acceptable in higher-risk patients, it may not be so in those of lower risk. METHODS AND RESULTS: Forty patients undergoing TAVI with the Edwards SAPIEN-XT(™) prosthesis were prospectively studied...
November 15, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27847343/fish-trim32-functions-as-a-critical-antiviral-molecule-against-iridovirus-and-nodavirus
#8
Yepin Yu, Xiaohong Huang, Jiaxin Liu, Jingcheng Zhang, Yin Hu, Ying Yang, Youhua Huang, Qiwei Qin
Tripartite motif-containing 32 (TRIM32) has been demonstrated to pay vital roles in cancer, genetic disorders and antiviral immunity. However, the molecular functions of fish TRIM32 still remained largely unknown. Here, a novel TRIM32 gene from orange spotted grouper (EcTRIM32) was cloned and characterized. EcTRIM32 encoded a 685-aa protein which showed 93%, and 60% identity to large yellow croaker (Larimichthys crocea) and human (Homo sapiens), respectively. Amino acid alignment showed that EcTRIM32 contained a conserved RING-finger domain, a BBOX domain and NHL domain...
November 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27846807/balloon-expandable-transcatheter-aortic-valve-implantation-via-the-transfemoral-route-with-or-without-pre-dilation-of-the-aortic-valve-rationale-and-design-of-a-multicentre-registry-ease-it-tf
#9
Christian Butter, Peter Bramlage, Tanja Rudolph, Claudius Jacobshagen, Jürgen Rothe, Hendrik Treede, Sebastian Kerber, Derk Frank, Lenka Seilerova, Gerhard Schymik
BACKGROUND: Transcatheter aortic valve implantation via the transfemoral route (TF-TAVI) is commonly performed as a treatment for severe aortic stenosis (AS) in patients at high surgical risk. Pre-deployment balloon aortic valvuloplasty (BAV) has generally been considered an essential step for preparing the valve landing zone for receipt of the prosthesis. However, there is little evidence supporting the clinical value of BAV, while several associated complications have been documented...
November 15, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27846458/predictive-factor-and-clinical-consequence-of-left-bundle-branch-block-after-a-transcatheter-aortic-valve-implantation
#10
Takahiko Nishiyama, Sho Tanosaki, Makoto Tanaka, Ryo Yanagisawa, Fumiaki Yashima, Takehiro Kimura, Takahide Arai, Hikaru Tsuruta, Mitsushige Murata, Yoshiyasu Aizawa, Takashi Kohno, Yuichiro Maekawa, Kentaro Hayashida, Seiji Takatsuki, Keiichi Fukuda
BACKGROUND: Atrioventricular conduction disturbances can develop after transcatherter aortic valve implantations (TAVIs) with balloon-expandable valves because the conduction system exists adjacent to the aortic valve. However, the clinical consequence of patients with new onset conduction disturbances is not clear. OBJECTIVE: This study aimed to assess the incidence and progress of new-onset conduction disturbances following TAVIs and the cardiac function evaluated by echocardiography...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27845874/initial-single-center-experience-with-the-fully-repositionable-transfemoral-lotus-aortic-valve-system
#11
Kai-Uwe Jarr, Florian Leuschner, Benjamin Meder, Hugo A Katus, Raffi Bekeredjian, Emmanuel Chorianopoulos
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has become the standard therapy for patients with severe symptomatic aortic stenosis and unacceptable high risk for surgical aortic valve replacement. Several different devices for TAVR have been introduced so far, each of them with unique features. AIMS: To analyze our first real-world experience with the second- generation, mechanically expanded, fully repositionable transfemoral Lotus TAVR device (Boston Scientific)...
November 15, 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27832845/predictors-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-replacement-with-the-sapien-3
#12
Victor Mauri, Andreas Reimann, Daniel Stern, Maximilian Scherner, Elmar Kuhn, Volker Rudolph, Stephan Rosenkranz, Kaveh Eghbalzadeh, Kai Friedrichs, Thorsten Wahlers, Stephan Baldus, Navid Madershahian, Tanja K Rudolph
OBJECTIVES: The aim of this study was to identify predictors of permanent pacemaker implantation (PPMI) following transcatheter aortic valve replacement (TAVR) with a balloon-expandable transcatheter valve (Edwards SAPIEN 3). BACKGROUND: New-onset conduction disturbances requiring PPMI remain a major concern following TAVR. Predictors are not yet well defined. METHODS: The influence of angiographic implantation depth, device landing zone calcium volume, oversizing, pre- and post-dilation, and baseline conduction disturbances on PPMI rate was analyzed in 229 patients undergoing TAVR with the SAPIEN 3 device...
November 14, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27828833/percutaneous-management-of-failed-bioprosthetic-pulmonary-valves-in-patients-with-congenital-heart-defects
#13
Pierpaolo Tarzia, Erika Conforti, Alessandro Giamberti, Alessandro Varrica, Luca Giugno, Angelo Micheletti, Diana Negura, Luciane Piazza, Antonio Saracino, Mario Carminati, Massimo Chessa
AIMS: We reviewed our center experience in the field of transcatheter pulmonary valve-in-valve implantation (TPViV), that is emerging as a treatment option for patients with pulmonary bioprosthetic valve (BPV) dysfunction. METHODS: Between April 2008 and September 2015, a total of six patients with congenital heart disease (four men) underwent TPViV due to stenosis of preexisting BPV. Four patients received a Melody Medtronic Transcatheter Pulmonary Valve and two an Edward Sapien Valve...
November 8, 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27815200/fish-trim16l-exerts-negative-regulation-on-antiviral-immune-response-against-grouper-iridoviruses
#14
Yepin Yu, Xiaohong Huang, Jingcheng Zhang, Jiaxi Liu, Yin Hu, Ying Yang, Jia Cai, Youhua Huang, Qiwei Qin
Tripartite motif 16 (TRIM16), has been demonstrated to act as a tumor suppressor through affecting cell proliferation and migration or tumorigenicity in carcigenesis. However, the roles of TRIM16 in immune response were unknown up to now. Here, we cloned a TRIM16-like gene (TRIM16L) from orange spotted grouper (EcTRIM16L) and investigated its roles in response to virus infection. EcTRIM16L encoded a 478 amino acid peptide which showed 72% and 29% identity to large yellow croaker (Larimichthys crocea) and human (Homo sapiens), respectively...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27784220/structure-based-drug-discovery-of-rab38-protein-identification-of-antagonists-as-cancer-drug-candidates
#15
Uma Vuruputuri, Aboubakr Haredi Abdelmonsef, Ramasree Dulapalli, Thirupathi Dasari, Lavanya Souda Padmarao, Thirupathi Mukkera
Cancer is responsible for one in eight deaths worldwide. The Rab family members are involved in important processes including membrane trafficking, cell growth and differentiation. It has been shown that Rab38 is located in melanosomes, and overexpressed at the RNA level in melanoma cancers. Rab38 represents a novel class of cellular modulators that can affect both initiation or progression of tumor cells in Homo sapiens. In the present work, the 3D structure of Rab38 (211 residues) was generated using homology modelling method; the structure shows the presence of 6 α- helices and 6 β- strands...
October 26, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27774967/trans-subclavian-aortic-valve-replacement-with-various-bioprosthetic-valves-single-center-experience
#16
Hacı Ahmet Kasapkara, Abdullah Nabi Aslan, Hüseyin Ayhan, Serdal Baştuğ, Hakan Süygün, Telat Keleş, Tahir Durmaz, Engin Bozkurt
OBJECTIVE: Transcatheter aortic valve replacement (TAVR) has been accepted as an alternative to surgery in high risk or inoperable patients with severe aortic stenosis (AS). Although transfemoral approach is the most often preferred means of access, in patients with severe ilio-femoral arteriopathy, other vascular access sites may be required. The aim of the present study was to report our experience with trans-subclavian approach for TAVR using different valve systems. METHODS: Among 273 patients undergoing TAVR between June 2011 and May 2016, 10 patients (mean age: 68...
October 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/27746060/transapical-transcatheter-mitral-valve-in-valve-implantation-using-an-edwards-sapien-3-valve
#17
Cheng He, Gregory Scalia, Darren L Walters, Andrew Clarke
We describe a successful transcatheter, transapical mitral valve implant within a failed mitral bioprosthesis (valve-in-valve) in a symptomatic 86-year-old patient with prohibitive surgical risks, using the new Sapien 3 balloon-expandable valve. Post-deployment echocardiographic profile of the valve-in-valve was satisfactory and the patient was discharged from hospital uneventfully. This is the first reported case of the Sapien 3 valve used in the mitral valve-in-valve setting.
June 21, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27726292/rapid-pacing-using-the-0-035-in-retrograde-left-ventricular-support-wire-in-208-cases-of-transcatheter-aortic-valve-implantation-and-balloon-aortic-valvuloplasty
#18
Roland Hilling-Smith, James Cockburn, Maureen Dooley, Jessica Parker, Andrea Newton, Andrew Hill, Uday Trivedi, Adam de Belder, David Hildick-Smith
: Transcatheter aortic valve implantation (TAVI) and balloon aortic valvuloplasty (BAV) are now well established percutaneous procedures. These procedures almost always require bursts of rapid ventricular pacing to temporarily reduce cardiac output to facilitate the procedure, usually done via a temporary pacing wire inserted into the right ventricle. We describe a case series of 132 cases of TAVI and 76 BAV done using ventricular pacing via the left ventricular lead by simply connecting one electrode to the patient's skin and one electrode through the left ventricular (LV) wire...
October 11, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27717843/homology-modeling-of-homo-sapiens-lipoic-acid-synthase-substrate-docking-and-insights-on-its-binding-mode
#19
Ezhilarasi Krishnamoorthy, Sameer Hassan, Luke Elizabeth Hanna, Indira Padmalayam, Rama Rajaram, Vijay Viswanathan
Lipoic acid synthase (LIAS) is an iron-sulfur cluster mitochondrial enzyme which catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. Recently there has been significant interest in its role in metabolic diseases and its deficiency in LIAS expression has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy, suggesting a strong inverse correlation between LIAS reduction and disease status. In this study we use a bioinformatics approach to predict its structure, which would be helpful to understanding its role...
October 4, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27712043/molecular-simulations-bring-new-insights-into-protoporphyrinogen-ix-oxidase-protoporphyrinogen-ix-interaction-modes
#20
Baifan Wang, Xin Wen, Zhen Xi
Protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) catalyzes the oxidation of protoporphyrinogen IX (protogen IX) to protoporphyrin IX (proto IX) in the haem/chlorophyll biosynthetic pathway. Although extensive studies of PPO have already afforded many insights into its biological function and its significance to agriculture and medicine, details of the enzymatic mechanism as well as the nature of the specific amino acids involved in substrate binding still remain largely unknown due to the lack of structural information about protogen IX binding to PPO...
October 2016: Molecular Informatics
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