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https://www.readbyqxmd.com/read/28110484/upregulation-of-20-hete-synthetic-cytochrome-p450-isoforms-by-oxygen-glucose-deprivation-in-cortical-neurons
#1
Hui Zhang, John R Falck, Richard J Roman, David R Harder, Raymond C Koehler, Zeng-Jin Yang
20-Hydroxyeicosatetraenoic acid (20-HETE), a potent vasoconstrictor, is a cytochrome P450 (CYP) 4A/4F-derived metabolite of arachidonic acid. Inhibition of 20-HETE synthesis protects brain from ischemic injury. However, that protection is not associated with changes in cerebral blood flow. The present study examined whether CYP4A isoforms are expressed in neurons, whether they produce 20-HETE in neurons, and whether neuronally derived 20-HETE exerts direct neurotoxicity after oxygen-glucose deprivation (OGD)...
January 21, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28109920/myocardial-blood-flow-and-inflammatory%C3%A2-cardiac-sarcoidosis
#2
Matthew J Kruse, Lara Kovell, Edward K Kasper, Martin G Pomper, David R Moller, Lilja Solnes, Edward S Chen, Thomas H Schindler
OBJECTIVES: This study sought to evaluate the effects of inflammatory sarcoid disease on coronary circulatory function and the response to immune-suppressive treatment. BACKGROUND: Although positron emission tomography assessment of myocardial inflammation is increasingly applied to identify active cardiac sarcoidosis, its effect on coronary flow and immune-suppressive treatment remains to be characterized. METHODS: Thirty-two individuals who were referred for positron emission tomography/computed tomography were evaluated for known or suspected cardiac sarcoidosis applying (18)F-fluorodeoxyglucose to determine inflammation and (13)N-ammonia to assess for perfusion deficits following a high-fat/low-carbohydrate diet and fasting state >12 h to suppress myocardial glucose uptake...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109863/disruption-of-cortical-arterial-network-is-associated-with-the-severity-of-transient-neurological-events-after-direct-bypass-surgery-in-adult-moyamoya-disease
#3
Yusuke Egashira, Keita Yamauchi, Yukiko Enomoto, Noriyuki Nakayama, Shinichi Yoshimura, Toru Iwama
OBJECTIVE: Transient neurological events (TNEs) frequently occur after revascularization in adult moyamoya disease (MMD). In the present study, we hypothesized that cortical arterial network disruption may be associated with TNE severity following bypass surgery. METHODS: This retrospective study included 76 hemispheres in 45 consecutive adult MMD patients who underwent direct revascularization surgery at our institution. We classified cortical arterial network disruption grade (NDG) into the following four categories based on angiography: NDG 0, > 90% of suprasylvian cortical branches of the middle cerebral artery demonstrated anterograde filling; NDG 1, 50% to 90%; NDG 2, < 50%; NDG 3, none...
January 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28109082/microrna-133a-inhibits-proliferation-of-gastric-cancer-cells-by-downregulating-erbb2-expression
#4
Chang Li, Xiaoping Li, Shuohui Gao, Chang Li, Lianjun Ma
Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. It hasalready been established that miR-133a is involved in gastric cancer. In this study, we aimed to investigate the molecular mechanisms by which miR-133a inhibits the proliferation of gastric cancer cells. We analyzed the proliferative capacity of human gastric cancer cells SNU-1, using MTT assay. Cell apoptosis was determined using flow cytometry. The expression levels of ERBB2, p-ERK1/2 and p-AKT in SNU-1 cells were determined using Western blot analysis...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109080/microrna-21-inhibits-the-apoptosis-of-osteosarcoma-cell-line-saos-2-via-targeting-caspase-8
#5
Bin Xu, Hehuan Xia, Junming Cao, Zhihong Wang, Yipeng Yang, Yongsheng Lin
Currently, multiple microRNAs (miRNAs) have been found play vital roles in the pathogenesis of osteosarcoma. This studywas aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and correspondingly adjacent tissues were monitored by qPCR. Human osteosarcoma cells line SAOS-2 was transfected with either miR-21 mimic or miR-21 inhibitor, and then cell viability, survival and apoptosis were respectively measured by MTT, colony formation assay, and flow cytometry...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109009/using-flow-characteristics-in-three-dimensional-power-doppler-ultrasound-imaging-to-predict-complete-responses-in-patients-undergoing-neoadjuvant-chemotherapy
#6
Wei-Chung Shia, Yu-Len Huang, Hwa-Koon Wu, Dar-Ren Chen
OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108544/the-interplay-between-neutrophils-and-cd8-t-cells-improves-survival-in-human-colorectal-cancer
#7
Valeria Governa, Emanuele Trella, Valentina Mele, Luigi Tornillo, Francesca Amicarella, Eleonora Cremonesi, Maunele Giuseppe Muraro, Hui Xu, Raoul Droeser, Silvio Raffael Däster, Martin Bolli, Raffaele Rosso, Daniel Oertli, Serenella Eppenberger-Castori, Luigi Terracciano, Giandomenica Iezzi, Giulio C Spagnoli
PURPOSE: Tumor infiltration by different T lymphocyte subsets is known to be associated with favorable prognosis in colorectal cancer (CRC). Still debated is the role of innate immune system. We investigated clinical relevance, phenotypes and functional features of CRC infiltrating CD66b+ neutrophils and their crosstalk with CD8+ T cells. EXPERIMENTAL DESIGN: CD66b+ and CD8+ cell infiltration was analyzed by immunohistochemistry on a tissue microarray including >650 evaluable CRC samples...
January 20, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28108489/processing-of-egomotion-consistent-optic-flow-in-the-rhesus-macaque-cortex
#8
Benoit R Cottereau, Andrew T Smith, Samy Rima, Denis Fize, Yseult Héjja-Brichard, Luc Renaud, Camille Lejards, Nathalie Vayssière, Yves Trotter, Jean-Baptiste Durand
The cortical network that processes visual cues to self-motion was characterized with functional magnetic resonance imaging in 3 awake behaving macaques. The experimental protocol was similar to previous human studies in which the responses to a single large optic flow patch were contrasted with responses to an array of 9 similar flow patches. This distinguishes cortical regions where neurons respond to flow in their receptive fields regardless of surrounding motion from those that are sensitive to whether the overall image arises from self-motion...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108361/development-and-characterization-of-new-functionalized-polyurethanes-for-sustained-and-site-specific-drug-release-in-the-gastrointestinal-tract
#9
María Dolores Campiñez, Elena Benito, Lucía Romero-Azogil, Ángela Aguilar-de-Leyva, María de Gracia García-Martín, Juan Antonio Galbis, Isidoro Caraballo
The main objective of the present paper has been the development and study of two new biodegradable polyurethanes, PU(dithiodiethanol-DTDI) and PU[((i)Pr)Man-DTDI], to be used as sustained matrix forming excipients. Furthermore, their capacity to act as excipient for colon drug delivery systems has been evaluated. Thus, SeDeM diagrams have been obtained to investigate their suitability to be processed through a direct compression process. Matrices containing 10-30% w/w of the polymers and theophylline anhydrous as model drug have been manufactured...
January 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28108083/impact-of-straight-unconnected-radially-oriented-and-tapered-mesopores-on-column-efficiency-a-theoretical-investigation
#10
Fabrice Gritti
Superficially porous particles (SPPs) can be prepared from a pseudomorphic transformation (PMT) which produces straight, unconnected, and radially-oriented mesopores (ROMs). ROMs can be either both ends open in fully porous particles (FPPs) or one-end-closed in SPPs. The impact of ROMs on the longitudinal diffusion (B/u), solid-liquid mass transfer resistance (Csu), and on the eddy dispersion (A(u)) height equivalent to a theoretical plate (HETP) of 3D randomly packed columns was investigated based on theoretical viewpoints...
January 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28108046/rules-of-performance-in-the-nursing-home-a-grounded-theory-of-nurse-cna-communication
#11
Connie Madden, Margaret Clayton, Heather Canary, Gail Towsley, Kristin Cloyes, Dale Lund
This study offers an initial theoretical understanding of nurse-CNA communication processes from the perspectives of nurses and CNAs who are providing direct care to residents in nursing homes. A grounded theory approach provided an understanding of nurse-CNA communication process within the complexities of the nursing home setting. Four themes (maintaining information flow, following procedure, fostering collegiality, and showing respect) describe the "rules of performance" that intertwine in nuanced relationships to guide nurse-CNA communication processes...
January 17, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28107955/matrix-isolation-with-an-ion-transfer-device-for-interference-free-simultaneous-spectrophotometric-determinations-of-hexavalent-and-trivalent-chromium-in-a-flow-based-system
#12
Shin-Ichi Ohira, Koretaka Nakamura, Mitsuki Chiba, Purnendu K Dasgupta, Kei Toda
Chromium speciation by spectrophotometric determination of hexavalent chromium (Cr(VI)) with diphenylcarbazide (DPC) has several problems. These include: (1) the inability to directly detect trivalent chromium (Cr(III)) with DPC, (2) positive interference in Cr(VI) determination by other metal cations and (3) negative interference by any reducing agent present in the sample. These are addressed with an ion transfer device (ITD) in a flow injection analysis system. We previously developed the ITD for electrodialytic separations...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107472/fractionation-of-magnetic-microspheres-in-a-microfluidic-spiral-interplay-between-magnetic-and-hydrodynamic-forces
#13
S Dutz, M E Hayden, U O Häfeli
Magnetic forces and curvature-induced hydrodynamic drag have both been studied and employed in continuous microfluidic particle separation and enrichment schemes. Here we combine the two. We investigate consequences of applying an outwardly directed magnetic force to a dilute suspension of magnetic microspheres circulating in a spiral microfluidic channel. This force is realized with an array of permanent magnets arranged to produce a magnetic field with octupolar symmetry about the spiral axis. At low flow rates particles cluster around an apparent streamline of the flow near the outer wall of the turn...
2017: PloS One
https://www.readbyqxmd.com/read/28106415/charge-dependent-directed-flow-in-cu-au-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev
#14
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, S Gupta, A Gupta, W Guryn, A I Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, B Huang, X Huang, H Z Huang, T Huang, P Huck, T J Humanic, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, Y Li, C Li, W Li, X Li, X Li, T Lin, M A Lisa, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, S Luo, G L Ma, R Ma, Y G Ma, L Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H S Matis, D McDonald, S McKinzie, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, B Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, Z Sun, Y Sun, X M Sun, B Surrow, D N Svirida, A H Tang, Z Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, R Varma, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, F Wang, J S Wang, Y Wang, H Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, K Xin, Q H Xu, Y F Xu, H Xu, Z Xu, N Xu, J Xu, C Yang, Y Yang, S Yang, Y Yang, Q Yang, Y Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, J Zhang, X P Zhang, S Zhang, Y Zhang, J B Zhang, Z Zhang, S Zhang, J Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present the first measurement of charge-dependent directed flow in Cu+Au collisions at sqrt[s_{NN}]=200  GeV. The results are presented as a function of the particle transverse momentum and pseudorapidity for different centralities. A finite difference between the directed flow of positive and negative charged particles is observed that qualitatively agrees with the expectations from the effects of the initial strong electric field between two colliding ions with different nuclear charges. The measured difference in directed flow is much smaller than that obtained from the parton-hadron-string-dynamics model, which suggests that most of the electric charges, i...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106340/gas-chromatography-with-mass-spectrometry-for-the-determination-of-phthalates-preconcentrated-by-microextraction-based-on-an-ionic-liquid
#15
Juan Ignacio Cacho, Natalia Campillo, Pilar Viñas, Manuel Hernández-Córdoba
A new procedure is proposed for the analysis of migration test solutions obtained from plastic bottles used in the packaging of edible oils. Ultrasound assisted emulsification microextraction with ionic liquids was applied for the preconcentration of six phthalate esters: dimethyl-, diethyl-, di-n-butyl, n-butylbenzyl, di-2-ethylhexyl and di-n-octylphthalate. The enriched ionic liquid was directly analyzed by gas chromatography and mass spectrometry using direct insert microvial thermal desorption. The different factors affecting the microextraction efficiency, like volume of the extracting phase (30 μL of the ionic liquid) and ultrasounds application time (25 s); and the thermal desorption step, such as desorption temperature and time, and gas flow rate, were studied...
January 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28105958/dmirnet-inferring-direct-microrna-mrna-association-networks
#16
Minsu Lee, HyungJune Lee
BACKGROUND: MicroRNAs (miRNAs) play important regulatory roles in the wide range of biological processes by inducing target mRNA degradation or translational repression. Based on the correlation between expression profiles of a miRNA and its target mRNA, various computational methods have previously been proposed to identify miRNA-mRNA association networks by incorporating the matched miRNA and mRNA expression profiles. However, there remain three major issues to be resolved in the conventional computation approaches for inferring miRNA-mRNA association networks from expression profiles...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28105824/fabrication-method-for-laboratory-scale-high-performance-membrane-electrode-assemblies-for-fuel-cells
#17
Megan B Sassin, Yannick Garsany, Benjamin D Gould, Karen E Swider-Lyons
Custom catalyst-coated membranes (CCMs) and membrane electrode assemblies (MEAs) are necessary for the evaluation of advanced electrocatalysts, gas diffusion media (GDM), ionomers, polymer electrolyte membranes (PEMs), and electrode structures designed for use in next-generation fuel cells, electrolyzers, or flow batteries. This Feature provides a reliable and reproducible fabrication protocol for laboratory scale (10 cm(2)) fuel cells based on ultrasonic spray deposition of a standard Pt/carbon electrocatalyst directly onto a perfluorosulfonic acid PEM...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105745/thin-soft-skin-mounted-microfluidic-networks-with-capillary-bursting-valves-for-chrono-sampling-of-sweat
#18
Jungil Choi, Daeshik Kang, Seungyong Han, Sung Bong Kim, John A Rogers
Systems for time sequential capture of microliter volumes of sweat released from targeted regions of the skin offer the potential to enable analysis of temporal variations in electrolyte balance and biomarker concentration throughout a period of interest. Current methods that rely on absorbent pads taped to the skin do not offer the ease of use in sweat capture needed for quantitative tracking; emerging classes of electronic wearable sweat analysis systems do not directly manage sweat-induced fluid flows for sample isolation...
January 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28105578/america-s-churning-races-race-and-ethnicity-response-changes-between-census-2000-and-the-2010-census
#19
Carolyn A Liebler, Sonya R Porter, Leticia E Fernandez, James M Noon, Sharon R Ennis
A person's racial or ethnic self-identification can change over time and across contexts, which is a component of population change not usually considered in studies that use race and ethnicity as variables. To facilitate incorporation of this aspect of population change, we show patterns and directions of individual-level race and Hispanic response change throughout the United States and among all federally recognized race/ethnic groups. We use internal U.S. Census Bureau data from the 2000 and 2010 censuses in which responses have been linked at the individual level (N = 162 million)...
January 19, 2017: Demography
https://www.readbyqxmd.com/read/28105222/curcumin-suppresses-the-proliferation-of-gastric-cancer-cells-by-downregulating-h19
#20
Gao Liu, Tian Xiang, Quan-Feng Wu, Wei-Xing Wang
Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. However, the long non-coding RNA H19 directly inhibits p53 activation and thus promotes gastric cancer progression. The aim of this study was to assess the role of H19 in curcumin-induced proliferative inhibition of gastric cancer. The gastric cancer cell line SGC-7901 was treated with curcumin at different concentrations and time points. The effect of curcumin on proliferation was assessed using cell counting kit-8 assays and flow cytometry with Ki67 staining...
December 2016: Oncology Letters
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