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Jing Wang, Bing Wang, Ling-Qiang Chen, Jin Yang, Zhi-Qiang Gong, Xue-Ling Zhao, Chun-Qiang Zhang, Kai-Li Du
OBJECTIVE: Osteosarcoma is a common malignancy with high rate of metastasis. miR-10b has been reported to be expressed in many types of tumors abnormally and be associated with cancer carcinogenesis and progression. But the function of miR-10b in osteosarcoma is still unknown. So this study was aimed to investigate the role of miR-10b in osteosarcoma development. METHODS: miR-10b expression in osteosarcoma tissues and osteosarcoma cells were detected using real time PCR...
October 17, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Suymara Toledo Miranda, Antonio Teixeira de Matos, Gheila Corrêa Ferres Baptestini, Alisson Carraro Borges
In horizontal subsurface flow constructed wetlands (HSSF-CWs), the main operational problem is clogging of the porous medium. In this study, the unclogging of HSSF-CWs was evaluated, at rest, by adding a nitrogen-based nutrient solution to the influent. For this, six HSSF-CWs were used, consisting of two uncultivated (CW-C), two cultivated with Tifton 85-grass (Cynodon spp.) (CW-T) and two cultivated with alligator weed (Alternanthera philoxeroides) (CW-A), which were fully clogged after being used for the treatment of swine wastewater...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Kun Zhong, Yi-Yong Luo, Zheng-Song Wu, Qiang He, Xue-Bin Hu, Qi-Wu Jie, Yan-Ting Li, Shao-Jie Wang
A vertical flow constructed wetland was combined with a biological aerated filter to develop an ecological filter, and to obtain the optimal operating parameters: The hydraulic loading was 1.55 m(3)/(m(2)·d), carbon-nitrogen ratio was 10, and gas-water ratio was 6. The experimental results demonstrated considerable removal efficiency of chemical oxygen demand (COD), ammonia nitrogen (NH4(+)-N), total nitrogen (TN), and total phosphorus (TP) in wastewater by the ecological filter, with average removal rates of 83...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Şivge Kurgan, Shevali Kansal, Daniel Nguyen, Danielle Stephens, Yannis Koroneos, Hatice Hasturk, Thomas E Van Dyke, Alpdogan Kantarci
BACKGROUND: Neutrophil function is critical for the initiation and progression of infecto-inflammatory diseases. Key quorum-sensing plaque bacteria such as Fusobacterium nucleatum act as bridging species between early and late colonizer pathogens such as Porphyromonas gingivalis as the biofilm ages and periodontal inflammation increases. This study was designed to determine the impact of different F. nucleatum strains on neutrophil function. MATERIALS AND METHODS: HL-60 cells were differentiated into neutrophil-like cells and cultured with F...
October 20, 2016: Journal of Periodontology
Mordjane Boukhet, Fabien Piguet, Hadjer Ouldali, Manuela Pastoriza-Gallego, Juan Pelta, Abdelghani Oukhaled
The transport of macromolecules through nanopores is involved in many biological functions and is today at the basis of promising technological applications. Nevertheless the interpretation of the dynamics of the macromolecule/nanopore interaction is still misunderstood and under debate. At the nanoscale, inside biomimetic channels under an external applied voltage, electrophoresis, which is the electric force acting on electrically charged molecules, and electroosmotic flow (EOF), which is the fluid transport associated with ions, contribute to the direction and magnitude of the molecular transport...
October 20, 2016: Nanoscale
Poornapriya Ramamurthy, Joshua B White, Joong Yull Park, Richard I Hume, Fumi Ebisu, Flor Mendez, Shuichi Takayama, Kate F Barald
BACKGROUND: To send meaningful information to the brain, an inner ear cochlear implant (CI) must become closely coupled to as large and healthy a population of remaining Spiral Ganglion Neurons (SGN) as possible. Inner ear gangliogenesis depends on macrophage migration inhibitory factor (MIF), a directionally attractant neurotrophic cytokine made by both Schwann and supporting cells (Bank et al., 2012). MIF-induced mouse embryonic stem cell (mESC)-derived "neurons" could potentially substitute for lost or damaged SGN...
October 19, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Lydia F Edey, Kieran P O'Dea, Bronwen R Herbert, Renyi Hua, Simon N Waddington, David A MacIntyre, Philip R Bennett, Masao Takata, Mark R Johnson
Inflammation plays a key role in human term and preterm labor (PTL). Intrauterine LPS has been widely used to model inflammation induced complications of pregnancy including PTL. It has been shown to induce an intense myometrial inflammatory cell infiltration, but the role of LPS-induced inflammatory cell activation in labor onset and fetal demise is unclear. We investigated this using a mouse model of PTL, where an intrauterine injection of 10 µg of LPS (serotype 0111:B4) was given at E16 of CD1 mouse pregnancy...
October 19, 2016: Biology of Reproduction
Aashish Kumar Sharma, R P Agrawal, J K Sharma, Ritvik Agrawal, Surendra Kumar, Kunal Thackar, Kailash Chandra Saini
OBJECTIVE: Vitamin D deficiency may be responsible for endothelial dysfunction which in turn affects the onset and progression of vascular disease including coronary artery disease and its risk factor, directly or indirectly through various mechanisms. This study was undertaken to find out association between vitamin D and endothelial dilatation of brachial artery, which may help to suggest possible underlying mechanisms and may be of clinical importance in planning preventive and therapeutic strategies...
July 2016: Journal of the Association of Physicians of India
Colette Veyrat, Christiane Bruel
On January 21 1968, nearly an half-century ago, a small Parisian group of cardiologists presented a directional Doppler prototype making possible the detection of forward and backward flows in the arteries. This princeps report, rapidly followed by the Directional Doppler recording of intracardiac flows, has upset the traditional approach to cardiovascular pathophysiology and launched a new examination method that will spread upon the whole word. Single CNRS researcher among this group of clinical cardiologists, Dr Colette Veyrat recalls this early period…...
October 2016: Médecine Sciences: M/S
Johannes F Wentzel, Martani J Lombard, Lissinda H Du Plessis, Lizelle Zandberg
Mycotoxins are toxic secondary metabolites produced by a range of fungi and are common contaminants of agricultural crops. These toxins are chemically diverse and structurally stable, enabling them to enter the food chain which can lead to numerous adverse health effects in animals and humans. Although mycotoxin exposure is associated with the development of several cancers, it has proved challenging to show a direct connection between exposure and oncogenic change. This study investigates the in vitro cytotoxicity, molecular mechanisms and secondary signalling responses associated with the exposure to three major mycotoxins, fumonisin B1 (FB1), deoxynivalenol (Don) and zearalenone (Zea)...
October 18, 2016: Archives of Toxicology
Wieland Fricke
Water transport in plants occurs along various paths and is driven by gradients in its free energy. It is generally considered that the mode of transport, being either diffusion or bulk flow, is a passive process, though energy may be required to sustain the forces driving water flow. This review aims at putting water flow at the various organisational levels (cell, organ, plant) in the context of the energy that is required to maintain these flows. In addition, the question is addressed (i) whether water can be transported against a difference in its chemical free energy, 'water potential' (Ψ), through, directly or indirectly, active processes; and (ii) whether the energy released when water is flowing down a gradient in its energy, for example during day-time transpiration and cell expansive growth, is significant compared to the energy budget of plant and cell...
October 18, 2016: Plant, Cell & Environment
Hirotsugu Nagase, Tomohira Takeoka, Shinya Urakawa, Akiko Morimoto-Okazawa, Atsunari Kawashima, Kota Iwahori, Shuji Takiguchi, Hiroyoshi Nishikawa, Eiichi Sato, Shimon Sakaguchi, Masaki Mori, Yuichiro Doki, Hisashi Wada
Regulatory T cells (Tregs) have an immunosuppressive role in the tumor microenvironment. Since effector Tregs (eTregs), which have highly suppressive functions, are located in a subpopulation of Foxp3(+) CD4(+) Tregs, the TCR-inducible costimulatory receptor (ICOS) was applied as a marker of eTregs that infiltrated gastric cancer tissue and the induction pathway of ICOS(+) Foxp3(+) cells was analyzed by flow cytometry and immunohistochemistry. In tumor-infiltrating lymphocytes (TILs), ICOS(+) Foxp3(+) CD4(+) T cells were abundantly observed in the late stages of gastric cancer...
October 18, 2016: International Journal of Cancer. Journal International du Cancer
Nikolaus Luft, Piotr A Wozniak, Gerold C Aschinger, Klemens Fondi, Ahmed M Bata, René M Werkmeister, Doreen Schmidl, Katarzyna J Witkowska, Matthias Bolz, Gerhard Garhöfer, Leopold Schmetterer
Purpose: This study evaluated the validity of retinal perfusion measurements using laser speckle flowgraphy (LSFG) by means of in vitro experiments and direct comparison with dual-beam Doppler optical coherence tomography (D-OCT) in a healthy Caucasian population. Methods: The flow velocity of scattering solution pumped through a glass capillary was measured at 17 different flow velocities (range, 0.5-47 mm/s) using LSFG. The flow within the glass capillary was produced by a computer-controlled infusion pump...
October 1, 2016: Investigative Ophthalmology & Visual Science
Bérenger Bourgeois, Eduardo González, Anne Vanasse, Isabelle Aubin, Monique Poulin
The disruption of hydrological connectivity by human activities such as flood regulation or land-use changes strongly impacts riparian plant communities. However, landscape-scale processes have generally been neglected in riparian restoration projects as opposed to local conditions, even though such processes might largely influence community recovery. We surveyed plant composition of field edges and riverbanks in 51 riparian zones restored by tree planting (565 1-m(2) plots) within two agricultural watersheds in southeastern Québec, Canada...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
Guohua Shi, Changhui Peng, Meng Wang, Shengwei Shi, Yanzheng Yang, Junyao Chu, Junjun Zhang, Guanghui Lin, Yan Shen, Qiuan Zhu
The lateral transport of dissolved organic carbon (DOC) plays an important role in linking the carbon cycles of terrestrial and aquatic ecosystems. Neglecting the lateral flow of dissolved organic carbon can lead to an underestimation of the organic carbon budget of terrestrial ecosystems. It is thus necessary to integrate DOC concentrations and flux into carbon cycle models, particularly with regard to the development of models that are intended to directly link terrestrial and ocean carbon cycles. However, to achieve this goal, more accurate information is needed to better understand and predict DOC dynamics...
2016: PloS One
Charbel Saade, Fadi El-Merhi, Bassam El-Achkar, Racha Kerek, Thomas J Vogl, Gilbert Georges Maroun, Lamia Jamjoom, Hussain Al-Mohiy, Lena Naffa
CLINICAL RELEVANCE STATEMENT: Caudocranial scan direction and contrast injection timing based on measured patient vessel dynamics can significantly improve arterial and aneurysmal opacification and reduce both contrast and radiation dose in the assessment of thoracic aortic aneurysms (TAA) using helical thoracic computed tomography angiography (CTA). OBJECTIVES: To investigate opacification of the thoracic aorta and TAA using a caudocranial scan direction and a patient-specific contrast protocol...
October 17, 2016: Journal of Computer Assisted Tomography
Miyeon Jung, John Jonides, Laurel Northouse, Marc G Berman, Todd M Koelling, Susan J Pressler
BACKGROUND: In heart failure (HF), attention may be decreased because of lowered cerebral blood flow and increased attentional demands needed for self-care. OBJECTIVE: Guided by the Attention Restoration Theory, the objective was to test the efficacy of the natural restorative environment (NRE) intervention on improving attention and mood among HF patients and healthy adults. METHODS: A randomized crossover pilot study was conducted among 20 HF patients and an age- and education-matched comparison group of 20 healthy adults to test the efficacy of the NRE intervention compared with an active control intervention...
October 14, 2016: Journal of Cardiovascular Nursing
Guangpu Zhu, Jun Yao, Lei Zhang, Hai Sun, Aifen Li
A large amount of residual oil, which exists as isolated oil slugs, remains trapped in reservoirs after water flooding. Numerous numerical studies are performed to investigate the fundamental flow mechanism of oil slugs to improve flooding efficiency. Dynamic contact angle models are usually introduced to simulate an accurate contact angle and meniscus displacement of oil slug under a high capillary number. Nevertheless, in the oil slug flow simulation process, it is unnecessary to introduce the dynamic contact angle model due to a negligible change of meniscus displacement after using the dynamic contact angle model when the capillary number is small...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Trefor Morgan
Central Systolic Blood Pressure is lower than brachial artery blood Pressure due to reflected waves and greater augmentation at the periphery. The relationship is not consistent during life and alters with aging of the blood vessels. Increasing stiffness means that a greater component of the reflected waves returns to the central aorta during systolic contraction causing more amplification and a higher systolic blood pressure. Diastolic blood pressure on the other hand is always higher in the aorta than at the periphery allowing blood flow...
September 2016: Journal of Hypertension
Peter F Davies, Elisabetta Manduchi, Christian J Stoeckert, Yi-Zhou Jiang
Hemodynamics creates a constantly changing physical and chemical environment to which the arterial endothelium is exquisitely sensitive. Biomechanical stresses are intrinsic to blood flow characteristics and blood pressure and therefore are important considerations in hypertension. Near branching anatomical sites in arteries, blood flow separates from the main flow to undergo complex multi-directional characteristics for a part of each cardiac cycle (collectively referred to as disturbed flow). Atherosclerosis and aneurysmal pathology develop preferentially at disturbed flow locations, particularly when an additional cardiovascular risk factor such as hypercholesterolemia or high blood pressure are present...
September 2016: Journal of Hypertension
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