keyword
https://read.qxmd.com/read/38524569/txnrd1-as-a-prognosticator-for-recurrence-metastasis-and-response-to-neoadjuvant-chemotherapy-and-radiotherapy-in-breast-cancer-patients
#1
JOURNAL ARTICLE
Raghavendra S Patwardhan, Archita Rai, Deepak Sharma, Santosh K Sandur, Sejal Patwardhan
Thioredoxin reductase 1 (Txnrd1) is known to have prognostic significance in a subset of breast cancer patients. Despite the pivotal role of Txnrd1 in regulating several cellular and physiological processes in cancer progression and metastasis, its clinical significance is largely unrecognized. Here, we undertook a retrospective comprehensive meta-analysis of 13,322 breast cancer patients from 43 independent cohorts to assess prognostic and predictive roles of Txnrd1. We observed that Txnrd1 has a positive correlation with tumor grade and size and it is over-expressed in higher-grade and larger tumors...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38520803/endometrial-preparation-protocols-did-not-impact-pregnancy-outcomes-of-patients-with-cured-chronic-endometritis
#2
JOURNAL ARTICLE
Hongzhan Zhang, Han Qiu, Zhiqiang Liu, Shuyi Yu, Cong Chen, Yong Zeng, Yuye Li
RESEARCH QUESTION: Do endometrial preparation protocols have an effect on pregnancy outcomes in patients with cured chronic endometritis? DESIGN: A retrospective study was conducted on 3721 infertile patients from December 2018 to August 2020. Endometrial tissues obtained during the proliferative phase were immunostained for CD138. The presence of CD138-positive cells within the stromal cells indicated chronic endometritis. All patients diagnosed with chronic endometritis received oral antibiotics...
November 27, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38519984/recent-advances-in-the-potential-effects-of-natural-products-from-traditional-chinese-medicine-against-respiratory-diseases-targeting-ferroptosis
#3
REVIEW
Tian Chen, Lu Ding, Meiru Zhao, Siyu Song, Juan Hou, Xueyan Li, Min Li, Kai Yin, Xiangyan Li, Zeyu Wang
Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability to target multiple pathways and mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions...
March 22, 2024: Chinese Medicine
https://read.qxmd.com/read/38519272/avoiding-weekend-frozen-embryo-transfer-in-modified-natural-cycles-is-it-possible
#4
JOURNAL ARTICLE
Barbara Lawrenz, Christophe Blockeel
In this era of the freeze-all strategy, the prevalence of frozen embryo transfer (FET) cycles is increasing rapidly. Although still quite often used, the hormone replacement therapy cycle to prepare a FET should now belong to the past, unless strictly necessary. This raises questions about possible flexible protocols for the preparation of an FET cycle in a (modified) natural cycle. In this viewpoint, an overview of the different options is discussed, stressing the importance of the corpus luteum.
December 17, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38516987/women-at-altitude-menstrual-cycle-phase-menopause-and-exogenous-progesterone-are-not-associated-with-acute-mountain-sickness
#5
JOURNAL ARTICLE
Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel
Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. High Alt Med Biol. 00:000-000, 2024. Background: Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS...
March 22, 2024: High Altitude Medicine & Biology
https://read.qxmd.com/read/38504208/developing-liver-targeted-naringenin-nanoparticles-for-breast-cancer-endocrine-therapy-by-promoting-estrogen-metabolism
#6
JOURNAL ARTICLE
Yuying Zhao, Hanxu Tan, Juping Zhang, Dandan Zhan, Bowen Yang, Shicui Hong, Bo Pan, Neng Wang, Tongkai Chen, Yafei Shi, Zhiyu Wang
Endocrine therapy is standard for hormone receptor-positive (HR+ ) breast cancer treatment. However, current strategies targeting estrogen signaling pay little attention to estradiol metabolism in the liver and is usually challenged by treatment failure. In a previous study, we demonstrated that the natural compound naringenin (NAR) inhibited HR+ breast cancer growth by activating estrogen sulfotransferase (EST) expression in the liver. Nevertheless, the poor water solubility, low bio-barrier permeability, and non-specific distribution limited its clinical application, particularly for oral administration...
March 19, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38499799/a-method-for-predicting-drugs-that-can-boost-the-efficacy-of-immune-checkpoint-blockade
#7
JOURNAL ARTICLE
Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy. The CM-Drug method was validated using melanoma and lung cancer mouse models, with combined therapeutic efficacy demonstrated in eight of nine predicted compounds...
March 18, 2024: Nature Immunology
https://read.qxmd.com/read/38494923/directed-differentiation-of-human-embryonic-stem-cells-into-parathyroid-cells-and-establishment-of-parathyroid-organoids
#8
JOURNAL ARTICLE
Ge Wang, Yaying Du, Xiaoqing Cui, Tao Xu, Hanning Li, Menglu Dong, Wei Li, Yajie Li, Wenjun Cai, Jia Xu, Shuyu Li, Xue Yang, Yonglin Wu, Hong Chen, Xingrui Li
Differentiation of human embryonic stem cells (hESCs) into human embryonic stem cells-derived parathyroid-like cells (hESC-PT) has clinical significance in providing new therapies for congenital and acquired parathyroid insufficiency conditions. However, a highly reproducible, well-documented method for parathyroid differentiation remains unavailable. By imitating the natural process of parathyroid embryonic development, we proposed a new hypothesis about the in vitro differentiation of parathyroid-like cells...
March 18, 2024: Cell Proliferation
https://read.qxmd.com/read/38489002/effects-of-calorie-restriction-on-preserving-male-fertility-particularly-in-a-state-of-obesity
#9
REVIEW
Mohammad Ishraq Zafar, Xiao Chen
PURPOSE OF REVIEW: Highlight the importance of exploring nutritional interventions that could be applied as alternative or supplementary therapeutic strategies to enhance men's fertility. RECENT FINDINGS: Lifestyle choices have prompted extensive discussions regarding its implications and applications as a complementary therapy. The growing concern over the decline in sperm quality underscores the urgency of investigating these alternative interventions. Calorie restriction (CR) has emerged as a promising strategy to improve male fertility...
March 15, 2024: Current Obesity Reports
https://read.qxmd.com/read/38481548/phytoformulation-with-hydroxycitric-acid-and-capsaicin-protects-against-high-fat-diet-induced-obesity-cardiomyopathy-by-reducing-cardiac-lipid-deposition-and-ameliorating-inflammation-and-apoptosis-in-the-heart
#10
JOURNAL ARTICLE
V V Sathibabu Uddandrao, P Chandrasekaran, G Saravanan, Parim Brahmanaidu, S Sengottuvelu, P Ponmurugan, S Vadivukkarasi, Umesh Kumar
BACKGROUND AND AIM: Phytoformulation therapy is a pioneering strategy for the treatment of metabolic disorders and related diseases. The aim of the present study was to investigate the protective effect of a phytoformulation consisting of hydroxycitric acid and capsaicin against obesity-related cardiomyopathy. EXPERIMENTAL PROCEDURE: Sprague-Dawley rats were fed HFD for 21 weeks, and phytoformulation (100 mg/kg body weight) was administered orally for 45 days starting at week 16...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38467155/recent-advances-in-molecular-pathways-and-therapeutic-implications-for-peptic-ulcer-management-a-comprehensive-review
#11
JOURNAL ARTICLE
Deepak Chandra Joshi, Nirmal Joshi, Ajeet Kumar, Shubhrat Maheshwari
Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5-10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and therapeutic advancements. The review deepens into H. pylori -associated and NSAID-induced ulcers, emphasizing their distinct prevalence in developing and industrialized nations, respectively...
March 11, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38465574/you-may-delay-but-time-will-not-beta-cells-lost-are-never-found-again-a-case-for-timely-initiation-of-basal-insulin-in-type-2-diabetes
#12
REVIEW
Susan Renda, Jeffrey Freeman
Since its first use just over a century ago, insulin treatment has evolved dramatically, such that the molecules are physiologic in nature, and treatment can now closely resemble the natural hormone response over 24 hours. Newer, longer-acting basal insulin analogs have provided insulin therapies with improved characteristics and, therefore, ease of use, and can readily be incorporated as part of routine treatment for type 2 diabetes (T2D), but evidence suggests that insulin remains underused in people with T2D...
March 11, 2024: Postgraduate Medicine
https://read.qxmd.com/read/38465078/clinical-outcomes-in-hormone-replacement-therapy-hrt-frozen-embryo-transfer-fet-protocol-increased-by-administering-gonadotropin-releasing-hormone-agonist-gnrh-in-the-initial-stage-of-the-luteal-phase-a-retrospective-analysis
#13
JOURNAL ARTICLE
Aamir Mahmood, Li Tan
OBJECTIVE: The objective of this study was to determine if gonadotropin-releasing hormone agonist (GnRH) administration supporting the luteal phase in frozen embryo transfer (FET) improves clinical outcomes Methods and materials This is a retrospective cohort study and we analyzed 3515 cycles of FET at the Department of Reproductive Medicine in our hospital from February 2018 through December 2021. Patients were divided into the GnRH (triptorelin+progesterone and human chorionic gonadotropin (hCG)) group and the non-GnRHa (existing treatment without triptorelin) group...
February 2024: Curēus
https://read.qxmd.com/read/38463422/exploiting-natural-language-processing-to-unveil-topics-and-trends-of-traumatic-brain-injury-research
#14
JOURNAL ARTICLE
Mert Karabacak, Ankita Jain, Pemla Jagtiani, Zachary L Hickman, Kristen Dams-O'Connor, Konstantinos Margetis
Traumatic brain injury (TBI) has evolved from a topic of relative obscurity to one of widespread scientific and lay interest. The scope and focus of TBI research have shifted, and research trends have changed in response to public and scientific interest. This study has two primary goals: first, to identify the predominant themes in TBI research; and second, to delineate "hot" and "cold" areas of interest by evaluating the current popularity or decline of these topics. Hot topics may be dwarfed in absolute numbers by other, larger TBI research areas but are rapidly gaining interest...
2024: Neurotrauma reports
https://read.qxmd.com/read/38459395/infertility-and-risk-of-postmenopausal-breast-cancer-in-the-women-s-health-initiative
#15
JOURNAL ARTICLE
Leslie V Farland, Kimberly E Lind, Cynthia A Thomson, Nazmus Saquib, Aladdin H Shadyab, Peter F Schnatz, Rogelio Robles-Morales, Lihong Qi, Howard Strickler, Dorothy S Lane, Gayathree Murugappan, Denise J Roe, Holly R Harris
PURPOSE: Although infertility (i.e., failure to conceive after ≥ 12 months of trying) is strongly correlated with established breast cancer risk factors (e.g., nulliparity, number of pregnancies, and age at first pregnancy), its association with breast cancer incidence is not fully understood. Previous studies were primarily small clinic-based or registry studies with short follow-up and predominantly focused on premenopausal breast cancer. The objective of this study was to assess the relationship between infertility and postmenopausal breast cancer risk among participants in the Women's Health Initiative (analytic sample = 131,784; > 25 years of follow-up)...
March 9, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38458891/olaparib-combined-with-abiraterone-versus-olaparib-monotherapy-for-patients-with-metastatic-castration-resistant-prostate-cancer-progressing-after-abiraterone-and-harboring-dna-damage-repair-deficiency-a-multicenter-real-world-study
#16
JOURNAL ARTICLE
Jun Xie, Hanxu Guo, Baijun Dong, Wei Chen, Chengqi Jin, Qiufan Xu, Li Ding, Wujianhong Liu, Shengrong Dong, Tingting Zhao, Yang Yu, Changcheng Guo, Xudong Yao, Bo Peng, Bin Yang
BACKGROUND AND OBJECTIVE: Olaparib + abiraterone has a combined antitumor effect in metastatic castration-resistant prostate cancer (mCRPC), but the efficacy of this combination in patients with DNA damage repair (DDR)-deficient mCRPC progressing after abiraterone is unknown. Our aim was to compare the efficacy of olaparib + abiraterone versus olaparib monotherapy for patients with DDR-deficient mCRPC progressing after abiraterone. METHODS: The study included 86 consecutive patients with DDR-deficient mCRPC progressing after abiraterone: 34 received olaparib + abiraterone, and 52 received olaparib monotherapy...
March 7, 2024: European Urology Oncology
https://read.qxmd.com/read/38458217/managing-menopause-after-cancer
#17
REVIEW
Martha Hickey, Partha Basu, Jenifer Sassarini, Mariken E Stegmann, Elisabete Weiderpass, Karen Nakawala Chilowa, Cheng-Har Yip, Ann H Partridge, Donal J Brennan
Globally, 9 million women are diagnosed with cancer each year. Breast cancer is the most commonly diagnosed cancer worldwide, followed by colorectal cancer in high-income countries and cervical cancer in low-income countries. Survival from cancer is improving and more women are experiencing long-term effects of cancer treatment, such as premature ovarian insufficiency or early menopause. Managing menopausal symptoms after cancer can be challenging, and more severe than at natural menopause. Menopausal symptoms can extend beyond hot flushes and night sweats (vasomotor symptoms)...
March 9, 2024: Lancet
https://read.qxmd.com/read/38457060/initiation-of-cancer-the-journey-from-mutations-in-somatic-cells-to-epigenetic-changes-in-tissue-resident-vsels
#18
REVIEW
Deepa Bhartiya, Sherif Raouf, Kshama Pansare, Anish Tripathi, Ashish Tripathi
Multiple theories exist to explain cancer initiation, although a consensus on this is crucial for developing effective therapies. 'Somatic mutation theory' suggests that mutations in somatic cells during DNA repair initiates cancer but this concept has several attached paradoxes. Research efforts to identify quiescent cancer stem cells (CSCs) that survive therapy and result in metastasis and recurrence have remained futile. In solid cancers, CSCs are suggested to appear during epithelial-mesenchymal transition by the dedifferentiation and reprogramming of epithelial cells...
March 8, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38451095/-one-and-a-half-interdural-transcavernous-pituitary-transposition-rotation-for-protection-of-hypophyseal-portal-system-in-adult-peripheral-retroinfundibular-craniopharyngioma
#19
JOURNAL ARTICLE
Ao Shen, Yang Yu, Liang Lyu, Shu Jiang, Dongjie Zhou, Jianguo Xu, Peizhi Zhou
BACKGROUND AND OBJECTIVES: Craniopharyngiomas originate from the pituitary stalk (PS) and extend along the pituitary-hypothalamic axis. Peripheral retroinfundibular craniopharyngiomas, particularly, may have worse surgery outcomes than other types. This study aims to investigate the advantage of using "one-and-a-half" interdural transcavernous pituitary transposition/rotation to dissect the tumor from the residual stalk and hypophyseal portal system for this subtype of craniopharyngioma...
March 7, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38448497/sex-specific-associations-of-serum-cortisol-with-brain-biomarkers-of-alzheimer-s-risk
#20
JOURNAL ARTICLE
Lisa Mosconi, Schantel Williams, Caroline Carlton, Camila Zarate, Camila Boneu, Francesca Fauci, Trisha Ajila, Matilde Nerattini, Steven Jett, Caroline Andy, Michael Battista, Silky Pahlajani, Joseph Osborne, Roberta Diaz Brinton, Jonathan P Dyke
Emerging evidence implicates chronic psychological stress as a risk factor for Alzheimer's disease (AD). Herein, we examined the relationships between serum cortisol and multimodality brain AD biomarkers in 277 cognitively normal midlife individuals at risk for AD. Overall, higher cortisol was associated with lower total brain volume, lower glucose metabolism (CMRglc) in frontal cortex, and higher β-amyloid (Aβ) load in AD-vulnerable regions; and marginally associated with phosphocreatine to ATP ratios (PCr/ATP) in precuneus and parietal regions...
March 6, 2024: Scientific Reports
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