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Pierre Bertho, Adrien Pauvert, Thomas Pouderoux, Henri Robert
BACKGROUND: Osteo-chondral defects due to advanced osteochondritis of the knee eventually cause osteoarthritis. Autologous matrix-induced chondrogenesis (AMIC) may hold potential for overcoming the treatment challenges raised by defects larger than 2 cm2 . The primary objective of this study was to assess medium-term functional outcomes of AMIC. The secondary objective was to confirm the absence of adverse events. HYPOTHESIS: AMIC significantly improves knee function in patients with osteochondritis responsible for osteo-chondral defects grade III or IV in the International Cartilage Repair Society (ICRS) classification...
June 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Alexandre Roux, Céline Botella, Megan Still, Marc Zanello, Frédéric Dhermain, Philippe Metellus, Johan Pallud
BACKGROUND: There is no consensus concerning the management of adult posterior fossa metastasis-associated obstructive hydrocephalus patients, especially regarding surgical procedures. OBJECTIVES: Literature review to assess the surgical strategy in the management of metastatic brain tumor patients. DATA SOURCES: Literature search conducted on PubMed in November 2017 to identify all studies concerning brain metastases and obstructive hydrocephalus in the English language...
June 20, 2018: World Neurosurgery
Alex Evangelista do Amaral, Michele Patrícia Rode, Julia Cisilotto, Telma Erotides da Silva, Josiane Fischer, Camila Matiollo, Elayne Cristina de Morais Rateke, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon, Tânia Beatriz Creczynski-Pasa
MicroRNAs (miRNAs) have remarkable potential as diagnostic and prognostic markers because of their roles in disease pathogenesis. miRNAs can be released into the bloodstream, where they are sufficiently stable to be detected noninvasively. Here, we prospectively evaluated serum levels of miR-21, miR-34a, miR-122, miR-181b, and miR-885-5p in patients with stable cirrhosis. Total RNA was extracted from the sera of patients with cirrhosis and healthy individuals, and the expression levels of the target miRNAs were analyzed by reverse transcription-quantitative polymerase chain reaction...
June 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Katie S Murray, Massimiliano Spaliviero, Emily S Tonorezos, Mario E Lacouture, William D Tap, Kevin C Oeffinger, Hebert Alberto Vargas, James A Eastham
OBJECTIVES: To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients. METHODS: We retrospectively identified 39 LFS patients treated at our institution between 2000 and 2014; 7 (18%) had experienced a GU malignancy or an LFS-related malignancy involving the GU tract. Clinical characteristics, including dates of onset of first GU tract malignancies; pathologic findings; multimodal management; and familial history of LFS were reviewed...
June 20, 2018: Urology
Giuseppe Cabibbo, Ciro Celsa, Calogero Cammà, Antonio Craxì
Direct acting antivirals (DAAs) stabilize or improve liver function in the majority of patients with HCV cirrhosis. Hepatic decompensation is the main driver of death of patients with early, successfully treated HCC superimposed to cirrhosis. Treatment with DAAs could improve the prognosis of these subjects, independently from the subsequent course of HCC, if the efficacy in obtaining viral clearance is as high as in patients without a history of HCC, and if the risk of HCC recurrence is unaffected. When dealing with HCC patients, DAAs can be indicated in two different settings: a) subjects in which HCC has been already successfully treated ("cured" HCC), or b) subjects whose HCC is still untreated or untreatable ("active" HCC)...
June 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Amani Hajlaoui, Wafa Slimani, Molka Kammoun, Amira Sallem, Fathi El Amri, Anouar Chaieb, Mohamed Bibi, Ali Saad, Soumaya Mougou-Zerelli
BACHGROUND: The subtelomeric rearrangements are increasingly being investigated in cases of idiopathic intellectual disabilities (ID) and congenital abnormalities (CA) but are also thought to be responsible for unexplained recurrent miscarriage (RM). Such rearrangements can go unnoticed through conventional cytogenetic techniques and are undetectable even with high-resolution molecular cytogenetic techniques such as array comparative genomic hybridization (aCGH), especially when DNA of the stillbirth or families are not available...
June 2018: International Journal of Fertility & Sterility
Arwa Younis, Ella Shaviv, Eyal Nof, Ariel Israel, Anat Berkovitch, Ilan Goldenberg, Michael Glikson, Robert Klempfner, Roy Beinart
BACKGROUND: Atrial fibrillation (AF) is associated with diminished cardiac function, and exercise tolerance. HYPOTHESIS: We sought to investigate the role of cardiac rehabilitation program (CR) in patients with AF. METHODS: The study included 2165 consecutive patients that participated in our CR program between the years 2009 - 2015. All were evaluated by a standard exercise stress test (EST) at baseline, and upon completion of at least 3 months of training...
June 23, 2018: Clinical Cardiology
Jun Miyauchi, Masaharu Ogura, Michio Sato, Junichi Matsui
Esophageal carcinosarcoma is a rare neoplasm with components of squamous cell carcinoma and sarcomatous spindle cell stroma. The latter may show overt mesenchymal differentiation but is thought to be derived from carcinoma cells in most cases. Here, we report a case of esophageal carcinosarcoma that appeared to be comprised of different origins of epithelial and mesenchymal tumor cells. The sarcomatous component formed an intralumial pedunculated large mass lesion that consisted of pleomorphic atypical histiocyte-like cells...
June 22, 2018: Pathology International
Ayhan Saglik, Hakim Celik
PURPOSE: To compare the accuracy of the anterior corneal simulated keratometry (SimK) and the Holladay equivalent keratometry reading (EKR) provided by a Scheimpflug camera (Pentacam HR) with the keratometry (K) provided by a Placido system (T-Cone topography) in keratoconus and control eyes. METHODS: This prospective study included 40 consecutive patients with keratoconus and 40 voluntary participants with no ocular complaints. Any patients with corneal scar, corneal trauma, history of corneal surgery or contact lens usage were excluded from the study...
June 22, 2018: International Ophthalmology
Narsis A Kiani, Ming-Mei Shang, Hector Zenil, Jesper Tegner
In this review we address to what extent computational techniques can augment our ability to predict toxicity. The first section provides a brief history of empirical observations on toxicity dating back to the dawn of Sumerian civilization. Interestingly, the concept of dose emerged very early on, leading up to the modern emphasis on kinetic properties, which in turn encodes the insight that toxicity is not solely a property of a compound but instead depends on the interaction with the host organism. The next logical step is the current conception of evaluating drugs from a personalized medicine point of view...
2018: Methods in Molecular Biology
Anne G Sammarco, Daniel M Morgan, Neil S Kamdar, Carolyn W Swenson
OBJECTIVES: To (1) determine the proportion of hysterectomy cases with documentation of pessary counseling prior to prolapse surgery and (2) identify variables associated with women offered a pessary. STUDY DESIGN: The Michigan Surgical Quality Collaborative (MSQC) is a hysterectomy improvement initiative. Hysterectomies from 2013 to 2015 in which prolapse was the principal diagnosis were included. "Pessary offer" was defined as documentation showing the patient declined, could not tolerate, or failed a pessary trial...
June 22, 2018: International Urogynecology Journal
Mohammad Abdelghani, Martina Nassif, Nico A Blom, Martijn S Van Mourik, Bart Straver, David R Koolbergen, Jolanda Kluin, Jan G Tijssen, Barbara J M Mulder, Berto J Bouma, Robbert J de Winter
BACKGROUND: Infective endocarditis (IE) after transcatheter pulmonary valve implantation (TPVI) in dysfunctioning right ventricular outflow tract conduits has evoked growing concerns. We aimed to investigate the incidence and the natural history of IE after TPVI with the Melody valve through a systematic review of published data. METHODS AND RESULTS: PubMed, EMBASE, and Web of Science databases were systematically searched for articles published until March 2017, reporting on IE after TPVI with the Melody valve...
June 22, 2018: Journal of the American Heart Association
Loïc Chaigneau, Anna Patrikidou, Isabelle Ray-Coquard, Thibaud Valentin, Claude Linassier, Jacques Olivier Bay, Laurence Moureau Zabotto, Emmanuelle Bompas, Sophie Piperno-Neumann, Nicolas Penel, Thierry Alcindor, Maryline Laigre, Cecile Guillemet, Sebastien Salas, Anne Hugli, Julien Domont, Marie Pierre Sunyach, Axel Lecesne, Jean Yves Blay, Virginie Nerich, Nicolas Isambert
BACKGROUND: Brain metastases (BM) from adult soft tissue or bone sarcomas are rare, and sparse data exist on their prognostic factors and management. SUBJECTS, MATERIALS AND METHODS: A retrospective study was conducted in 15 centers of the French Sarcoma Group, plus one Canadian and one Swiss center, to report on clinical, histological, and treatment characteristics and to identify predictive factors of outcome. RESULTS: Between 1992 and 2012, 246 patients with a median age of 50 years (range: 16-86) were managed for BM...
June 22, 2018: Oncologist
Lawrence H Young, Catherine M Viscoli, Gregory G Schwartz, Silvio E Inzucchi, Jeptha P Curtis, Mark J Gorman, Karen L Furie, Robin Conwit, Erica Spatz, Anne Lovejoy, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Frederick S Ling, Steven E Pfau, Walter N Kernan
Background -The Insulin Resistance Intervention after Stroke (IRIS) trial demonstrated that pioglitazone reduced risk for both cardiovascular events and diabetes in insulin resistant patients. However, concern remains that pioglitazone may increase risk for heart failure (HF) in susceptible individuals. Methods -In IRIS, patients with insulin resistance but without diabetes were randomized to pioglitazone or placebo (1:1) within 180 days of an ischemic stroke or TIA and followed for up to 5 years. To identify patients at higher HF risk with pioglitazone we performed a secondary analysis of IRIS participants without HF history at entry...
June 22, 2018: Circulation
Hans David Huang, William L Lombardi, Zachary Louis Steinberg
CLINICAL INTRODUCTION: A man in his early 30s with remote history of a febrile rash as a toddler presented to the emergency room following an out-of-hospital cardiac arrest while riding his bicycle. He received bystander cardiopulmonary resuscitation and one shock from an automatic external defibrillator, successfully restoring sinus rhythm. On arrival, he was haemodynamically stable without ECG evidence of ST segment changes to suggest active ischaemia, and an initial troponin I was mildly elevated at 0...
June 22, 2018: Heart: Official Journal of the British Cardiac Society
Emilie V Cheung, Eric J Sarkissian, Alex Sox-Harris, Garet C Comer, Jason R Saleh, Robert Diaz, John G Costouros
BACKGROUND: This study evaluated patients with and without a prosthetic dislocation after reverse total shoulder arthroplasty (RTSA) to identify risk factors for instability. METHODS: Dislocation and nondislocation cohorts were established for analysis in 119 patients who had undergone RTSA at our institution between 2011 and 2014. Preoperative history and parameters pertaining to RTSA design were evaluated for correlation with instability. A logistic regression model was used to analyze independent predictors...
June 19, 2018: Journal of Shoulder and Elbow Surgery
Hayato Kawachi, Daichi Fujimoto, Takeshi Morimoto, Munehiro Ito, Shunsuke Teraoka, Yuki Sato, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Keisuke Tomii
BACKGROUND: Most patients with non-small-cell lung cancer (NSCLC) are ineligible for clinical trials. However, few studies have reported on the profiles and treatment outcomes for these patients. Therefore, we investigated the characteristics, outcomes, and survival of patients with advanced NSCLC who were ineligible for clinical trials. MATERIALS AND METHODS: We analyzed the data from a retrospective cohort of 786 consecutive patients with a diagnosis of advanced NSCLC...
May 26, 2018: Clinical Lung Cancer
Daniel E Hess, Patricia Drace, Michael J Franco, A Bobby Chhabra
Carpometacarpal (CMC) arthroplasty surgery, although modifications have occurred over time, continues to be commonly performed and has provided patients with their desired pain relief and return of function. The complications of primary surgery, although relatively rare, can present in various clinical ways. An understanding of the underlying anatomy, pathology of coexisting conditions, and specific techniques used in the primary surgery is required to make the best recommendation for a patient with residual pain following primary CMC arthroplasty...
June 19, 2018: Journal of Hand Surgery
Nathalia de Almeida Freire, Bruno Augusto Benevenuto de Andrade, Nathalie Henriques Silva Canedo, Michelle Agostini, Mário José Romañach
Oral and maxillofacial metastatic tumors are uncommon, with the breast, prostate, lung, and kidney representing the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date, only 8 cases of metastatic breast adenocarcinoma to the oral and maxillofacial region in a male patient have been reported in the literature. An 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling lasting 6 months...
May 30, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Christopher G Watson, Christian Stopp, David Wypij, David C Bellinger, Jane W Newburger, Michael J Rivkin
OBJECTIVE: To compare white matter microstructure in children and adolescents with single ventricle who underwent the Fontan procedure with healthy controls, and to explore the association of white matter injury with cognitive performance as well as patient and medical factors. STUDY DESIGN: Fontan (n = 102) and control subjects (n = 47) underwent diffusion tensor imaging (DTI) at ages 10-19 years. Mean DTI measures (fractional anisotropy, radial diffusivity, axial diffusivity, and mean diffusivity) were calculated for 33 fiber tracts from standard white matter atlases...
June 19, 2018: Journal of Pediatrics
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