Catherine H Le, Lindsay G Benage, Kalyn S Specht, Lance C Li Puma, Christopher M Mulligan, Adam L Heuberger, Jessica E Prenni, Steven M Claypool, Kathryn C Chatfield, Genevieve C Sparagna, Adam J Chicco
Barth syndrome is a mitochondrial myopathy resulting from mutations in the tafazzin ( TAZ ) gene encoding a phospholipid transacylase required for cardiolipin remodeling. Cardiolipin is a phospholipid of the inner mitochondrial membrane essential for the function of numerous mitochondrial proteins and processes. However, it is unclear how tafazzin deficiency impacts cardiac mitochondrial metabolism. To address this question while avoiding confounding effects of cardiomyopathy on mitochondrial phenotype, we utilized Taz -shRNA knockdown ( TazKD ) mice, which exhibit defective cardiolipin remodeling and respiratory supercomplex instability characteristic of human Barth syndrome but normal cardiac function into adulthood...
August 28, 2020: Journal of Biological Chemistry