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Estrogen microbiome

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https://www.readbyqxmd.com/read/27897166/erratum-effects-of-low-dose-estrogen-therapy-on-the-vaginal-microbiomes-of-women-with-atrophic-vaginitis
#1
Jian Shen, Ning Song, Christopher J Williams, Celeste J Brown, Zheng Yan, Chen Xu, Larry J Forney
No abstract text is available yet for this article.
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27709424/gastrointestinal-microbiome-and-breast-cancer-correlations-mechanisms-and-potential-clinical-implications
#2
Jiqiao Yang, Qiuwen Tan, Qingyu Fu, Yaojie Zhou, Yuanyuan Hu, Shenli Tang, Yuting Zhou, Junhui Zhang, Juanjuan Qiu, Qing Lv
Gastrointestinal microbiome plays as a symbiont which provides protection effect against invading pathogens, aids in the immune system development, nutrient reclamation and absorption as well as molecule breakdown. And it may avert carcinogenesis through these biological activities. By now, studies have been carried out to elaborate the association between gastrointestinal microbiome and breast cancer. It has been implicated that breast cancer was substantially associated with estrogen-dependent and estrogen-independent functions of gastrointestinal microbiome...
October 5, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27698617/unraveling-the-dynamics-of-the-human-vaginal-microbiome
#3
Kenetta L Nunn, Larry J Forney
Four Lactobacillus species, namely L. crispatus , L. iners, L. gasseri, and L. jensenii, commonly dominate the vaginal communities of most reproductive-age women. It is unclear why these particular species, and not others, are so prevalent. Historically, estrogen-induced glycogen production by the vaginal epithelium has been proffered as being key to supporting the proliferation of vaginal lactobacilli. However, the 'fly in the ointment' (that has been largely ignored) is that the species of Lactobacillus commonly found in the human vagina cannot directly metabolize glycogen...
September 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27451320/menopause-and-the-vaginal-microbiome
#4
REVIEW
Alicia L Muhleisen, Melissa M Herbst-Kralovetz
For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect on vulvovaginal atrophy, vaginal dryness, sexual health and overall quality of life. As molecular-based techniques have evolved, our understanding of the diversity and complexity of this bacterial community has expanded...
September 2016: Maturitas
https://www.readbyqxmd.com/read/27125180/corrigendum-discovery-of-a-novel-seminal-fluid-microbiome-and-influence-of-estrogen-receptor-alpha-genetic-status
#5
Angela B Javurek, William G Spollen, Amber M Mann Ali, Sarah A Johnson, Dennis B Lubahn, Nathan J Bivens, Karen H Bromert, Mark R Ellersieck, Scott A Givan, Cheryl S Rosenfeld
No abstract text is available yet for this article.
2016: Scientific Reports
https://www.readbyqxmd.com/read/27107051/the-intestinal-microbiome-and-estrogen-receptor-positive-female-breast-cancer
#6
REVIEW
Maryann Kwa, Claudia S Plottel, Martin J Blaser, Sylvia Adams
The huge communities of residential microbes, including bacteria, viruses, Archaea, and Eukaryotes, that colonize humans are increasingly recognized as playing important roles in health and disease. A complex populous ecosystem, the human gastrointestinal (GI) tract harbors up to 10(11) bacterial cells per gram of luminal content, whose collective genome, the gut metagenome, contains a vastly greater number of individual genes than the human genome. In health, the function of the microbiome might be considered to be in dynamic equilibrium with the host, exerting both local and distant effects...
August 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27103314/effects-of-low-dose-estrogen-therapy-on-the-vaginal-microbiomes-of-women-with-atrophic-vaginitis
#7
Jian Shen, Ning Song, Christopher J Williams, Celeste J Brown, Zheng Yan, Chen Xu, Larry J Forney
Atrophic vaginitis (AV) is common in postmenopausal women, but its causes are not well understood. The symptoms, which include vaginal itching, burning, dryness, irritation, and dyspareunia, can usually be alleviated by low doses of estrogen given orally or locally. Regrettably, the composition of vaginal bacterial communities in women with AV have not been fully characterized and little is known as to how these communities change over time in response to hormonal therapy. In the present intervention study we determined the response of vaginal bacterial communities in postmenopausal women with AV to low-dose estrogen therapy...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26971397/discovery-of-a-novel-seminal-fluid-microbiome-and-influence-of-estrogen-receptor-alpha-genetic-status
#8
Angela B Javurek, William G Spollen, Amber M Mann Ali, Sarah A Johnson, Dennis B Lubahn, Nathan J Bivens, Karen H Bromert, Mark R Ellersieck, Scott A Givan, Cheryl S Rosenfeld
Bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease (DOHaD) effects in his offspring. Such effects could be due to the seminal fluid, which is slightly basic and enriched with carbohydrates; thereby, creating an ideal habitat for microbes or a potential seminal fluid microbiome (SFM). Using wild-type (WT) and estrogen receptor-alpha (ESR1) knockout (KO) male mice, we describe a unique SFM whose inhabitants differ from gut microbes...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26658991/risk-of-inflammatory-bowel-disease-with-oral-contraceptives-and-menopausal-hormone-therapy-current-evidence-and-future-directions
#9
Hamed Khalili
Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel diseases, are archetypical inflammatory disorders of the gastrointestinal tract with rising incidence worldwide. Although the role of genetic factors in disease development has been highlighted by genome-wide association studies, environmental risk factors likely play a pivotal role in development of CD and UC. Prior observational studies have suggested a link between exogenous hormone use and risk of CD and UC. Specifically, studies have shown an association between oral contraceptive use and risk of CD and menopausal hormone therapy and risk of UC...
March 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/26265751/ovariectomy-results-in-differential-shifts-in-gut-microbiota-in-low-versus-high-aerobic-capacity-rats
#10
Kimberly A Cox-York, Amy M Sheflin, Michelle T Foster, Christopher L Gentile, Amber Kahl, Lauren G Koch, Steven L Britton, Tiffany L Weir
The increased risk for cardiometabolic disease with the onset of menopause is widely studied and likely precipitated by the decline in endogenous estradiol (E2), yet the precise mechanisms are unknown. The gut microbiome is involved in estrogen metabolism and has been linked to metabolic disease, suggesting its potential involvement in the postmenopausal phenotype. Furthermore, menopause-associated risk factors, as well as gut ecology, are altered with exercise. Therefore, we studied microbial changes in an ovariectomized (OVX vs...
August 2015: Physiological Reports
https://www.readbyqxmd.com/read/25211668/associations-of-the-fecal-microbiome-with-urinary-estrogens-and-estrogen-metabolites-in-postmenopausal-women
#11
Barbara J Fuhrman, Heather Spencer Feigelson, Roberto Flores, Mitchell H Gail, Xia Xu, Jacques Ravel, James J Goedert
CONTEXT: The gut microbiota may influence the risk of breast cancer through effects on endogenous estrogens. OBJECTIVE: The objective of the study was to investigate whether urinary estrogens and estrogen metabolites are associated with the diversity and composition of the fecal microbiome. DESIGN AND SETTING: This was a cross-sectional study among women enrolled in Kaiser Permanente of Colorado. PARTICIPANTS: A total of 60 women drawn from a random sample of healthy postmenopausal women (aged 55-69 y), without current or recent use of antibiotics or hormone therapy and no history of cancer or gastrointestinal disease participated in the study...
December 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24390919/potential-influence-of-the-microbiome-on-infertility-and-assisted-reproductive-technology
#12
REVIEW
Ido Sirota, Shvetha M Zarek, James H Segars
Although an altered vaginal microbiota has been demonstrated to affect parturition, its role in assisted reproductive technologies is uncertain. Nevertheless, the effect of known pathogens such as Mycoplasma tuberculosis, Chlamydia trachomatis, and Neisseria gonorrhoeae is clear, causing subclinical changes thought to be risk factors in subfertility. The Human Microbiome Project (HMP) has allowed for metagenomic studies to aid in characterizing normal vaginal flora. Recent findings from the HMP demonstrate that many different species of Lactobacillus are present in the vaginal tract, with a few that predominate...
January 2014: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/24187630/evolving-concepts-how-diet-and-the-intestinal-microbiome-act-as-modulators-of-breast-malignancy
#13
REVIEW
Iuliana Shapira, Keith Sultan, Annette Lee, Emanuela Taioli
The intestinal microbiome plays an important role in human physiology. Next-generation sequencing technologies, knockout and gnotobiotic mouse models, fecal transplant data and epidemiologic studies have accelerated our understanding of microbiome abnormalities seen in immune diseases and malignancies. Dysbiosis is the disturbed microbiome ecology secondary to external pressures such as host diseases, medications, diet and genetic conditions often leading to abnormalities of the host immune system. Specifically dysbiosis has been shown to lower circulating lymphocytes, and increase neutrophil to lymphocyte ratio, a finding which has been associated with a decreased survival in women with breast cancers...
2013: ISRN Oncology
https://www.readbyqxmd.com/read/24166771/the-primate-vaginal-microbiome-comparative-context-and-implications-for-human-health-and-disease
#14
REVIEW
Rebecca M Stumpf, Brenda A Wilson, Angel Rivera, Suleyman Yildirim, Carl J Yeoman, John D Polk, Bryan A White, Steven R Leigh
The primate body hosts trillions of microbes. Interactions between primate hosts and these microbes profoundly affect primate physiology, reproduction, health, survival, and ultimately, evolution. It is increasingly clear that primate health cannot be understood fully without knowledge of host-microbial interactions. Our goals here are to review what is known about microbiomes of the female reproductive tract and to explore several factors that influence variation within individuals, as well as within and between primate species...
December 2013: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/23985562/management-of-symptomatic-vulvovaginal-atrophy-2013-position-statement-of-the-north-american-menopause-society
#15
(no author information available yet)
OBJECTIVE: To update and expand the previous position statement of The North American Menopause Society (NAMS) on the management of symptomatic vulvovaginal atrophy (VVA) in postmenopausal women. METHODS: NAMS searched PubMed for medical literature on VVA published since their 2007 position statement on the role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women. A panel of acknowledged experts in the field of genitourinary health reviewed the literature to evaluate new evidence on local estrogen as well as on other management options available or in development for symptomatic VVA...
September 2013: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/23259758/fecal-microbial-determinants-of-fecal-and-systemic-estrogens-and-estrogen-metabolites-a-cross-sectional-study
#16
Roberto Flores, Jianxin Shi, Barbara Fuhrman, Xia Xu, Timothy D Veenstra, Mitchell H Gail, Pawel Gajer, Jacques Ravel, James J Goedert
BACKGROUND: High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined. We sought to identify members and functions of the intestinal microbial community associated with estrogen levels via enterohepatic recirculation. METHODS: Fifty-one epidemiologists at the National Institutes of Health, including 25 men, 7 postmenopausal women, and 19 premenopausal women, provided urine and aliquots of feces, using methods proven to yield accurate and reproducible results...
2012: Journal of Translational Medicine
https://www.readbyqxmd.com/read/22656377/the-nutrigenetics-and-nutrigenomics-of-the-dietary-requirement-for-choline
#17
REVIEW
Karen D Corbin, Steven H Zeisel
Advances in nutrigenetics and nutrigenomics have been instrumental in demonstrating that nutrient requirements vary among individuals. This is exemplified by studies of the nutrient choline, in which gender, single-nucleotide polymorphisms, estrogen status, and gut microbiome composition have been shown to influence its optimal intake level. Choline is an essential nutrient with a wide range of biological functions, and current studies are aimed at refining our understanding of its requirements and, importantly, on defining the molecular mechanisms that mediate its effects in instances of suboptimal dietary intake...
2012: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/22632581/influence-of-dietary-phytochemicals-and-microbiota-on-colon-cancer-risk
#18
REVIEW
Ruth S Macdonald, Kelly Wagner
Colon cancer is the third most commonly diagnosed type of cancer in the United States. Lifestyle and dietary patterns influence colon cancer risk both positively and negatively. Among the dietary factors, several plant-derived compounds have been found to afford colon cancer protection. These compounds potentially influence all aspects of colonic cellular regulation and develop complex interrelationships with the colonic microbiome. Increasing understanding of the role of microorganisms in determining the colonic environment has led to awareness of this important interrelationship among dietary factors and the microbial population...
July 11, 2012: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/22134222/choline-metabolism-provides-novel-insights-into-nonalcoholic-fatty-liver-disease-and-its-progression
#19
REVIEW
Karen D Corbin, Steven H Zeisel
PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline. In the last few years, there have been significant advances in our understanding of the mechanisms that influence choline requirements in humans and in our understanding of choline's effects on liver function. These advances are useful in elucidating why nonalcoholic fatty liver disease (NAFLD) occurs and progresses sometimes to hepatocarcinogenesis...
March 2012: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/22073175/vaginal-microbiome-and-epithelial-gene-array-in-post-menopausal-women-with-moderate-to-severe-dryness
#20
Ruben Hummelen, Jean M Macklaim, Jordan E Bisanz, Jo-Anne Hammond, Amy McMillan, Rebecca Vongsa, David Koenig, Gregory B Gloor, Gregor Reid
After menopause, many women experience vaginal dryness and atrophy of tissue, often attributed to the loss of estrogen. An understudied aspect of vaginal health in women who experience dryness due to atrophy is the role of the resident microbes. It is known that the microbiota has an important role in healthy vaginal homeostasis, including maintaining the pH balance and excluding pathogens. The objectives of this study were twofold: first to identify the microbiome of post-menopausal women with and without vaginal dryness and symptoms of atrophy; and secondly to examine any differences in epithelial gene expression associated with atrophy...
2011: PloS One
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