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Estrogen microbiome glucuronidase

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https://www.readbyqxmd.com/read/29802368/long-term-administration-of-conjugated-estrogen-and-bazedoxifene-decreased-murine-fecal-%C3%AE-glucuronidase-activity-without-impacting-overall-microbiome-community
#1
Karen Lee Ann Chen, Xiaoji Liu, Yiru Chen Zhao, Kadriye Hieronymi, Gianluigi Rossi, Loretta Sue Auvil, Michael Welge, Colleen Bushell, Rebecca Lee Smith, Kathryn E Carlson, Sung Hoon Kim, John A Katzenellenbogen, Michael Joseph Miller, Zeynep Madak-Erdogan
Conjugated estrogens (CE) and Bazedoxifene (BZA) combination is used to alleviate menopause-associated symptoms in women. CE+BZA undergo first-pass-metabolism in the liver and deconjugation by gut microbiome via β-glucuronidase (GUS) enzyme inside the distal gut. To date, the impact of long-term exposure to CE+BZA on the gut microbiome or GUS activity has not been examined. Our study using an ovariectomized mouse model showed that CE+BZA administration did not affect the overall cecal or fecal microbiome community except that it decreased the abundance of Akkermansia, which was identified as a fecal biomarker correlated with weight gain...
May 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/23259758/fecal-microbial-determinants-of-fecal-and-systemic-estrogens-and-estrogen-metabolites-a-cross-sectional-study
#2
Roberto Flores, Jianxin Shi, Barbara Fuhrman, Xia Xu, Timothy D Veenstra, Mitchell H Gail, Pawel Gajer, Jacques Ravel, James J Goedert
BACKGROUND: High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined. We sought to identify members and functions of the intestinal microbial community associated with estrogen levels via enterohepatic recirculation. METHODS: Fifty-one epidemiologists at the National Institutes of Health, including 25 men, 7 postmenopausal women, and 19 premenopausal women, provided urine and aliquots of feces, using methods proven to yield accurate and reproducible results...
2012: Journal of Translational Medicine
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