L P Madhubhani P Hemachandra, Hitisha Patel, R Esala P Chandrasena, Jaewoo Choi, Sujeewa C Piyankarage, Shuai Wang, Yijin Wang, Emily N Thayer, Robert A Scism, Bradley T Michalsen, Rui Xiong, Marton I Siklos, Judy L Bolton, Gregory R J Thatcher
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabolites. Nontumorigenic MCF-10A human breast epithelial cells are classified as ER(-) and undergo estrogen-induced malignant transformation. Selective estrogen receptor modulators (SERM), in use for breast cancer chemoprevention and for postmenopausal osteoporosis, were observed to inhibit malignant transformation, as measured by anchorage-independent colony growth...
May 2014: Cancer Prevention Research