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https://www.readbyqxmd.com/read/29344809/regeneration-of-functional-alveoli-by-adult-human-sox9-airway-basal-cell-transplantation
#1
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition...
January 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29328793/novel-molecular-and-phenotypic-insights-into-congenital-lung-malformations
#2
Daniel T Swarr, William H Peranteau, Jennifer Pogoriler, David B Frank, N Scott Adzick, Holly L Hedrick, Mike Morley, Su Zhou, Edward E Morrisey
RATIONALE: Disruption of normal pulmonary development is a leading cause of morbidity and mortality in infants. Congenital lung malformations are a unique model to study the molecular pathogenesis of isolated structural birth defects as they are often surgically resected. OBJECTIVES: To provide insight into the molecular pathogenesis of congenital lung malformations through analysis of cell-type and gene expression changes in these lesions. METHODS: Clinical data, and lung tissue for DNA, RNA, and histology were obtained from 58 infants undergoing surgical resection of a congenital lung lesion...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29321987/gelam-honey-attenuates-ovalbumin-induced-airway-inflammation-in-a-mice-model-of-allergic-asthma
#3
Nur Salme Suhana Shamshuddin, Rozaini Mohd Zohdi
Allergic asthma is a chronic inflammatory disorder of the pulmonary airways. Gelam honey has been proven to possess anti-inflammatory property with great potential to treat an inflammatory condition. However, the effect of ingestion of Gelam honey on allergic asthma has never been studied. This study aimed to investigate the efficacy of Gelam honey on the histopathological changes in the lungs of a mice model of allergic asthma. Forty-two Balb/c mice were divided into seven groups: control, I, II, III, IV, V and VI group...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29311494/immunohistochemical-study-on-the-distribution-of-%C3%AE-defensin-1-and-%C3%AE-defensin-2-throughout-the-respiratory-tract-of-healthy-rats
#4
Natsumi Masuda, Youhei Mantani, Hideto Yuasa, Chiaki Yoshitomi, Masaya Arai, Miho Nishida, Wang-Mei Qi, Junichi Kawano, Toshifumi Yokoyama, Nobuhiko Hoshi, Hiroshi Kitagawa
The distributions of β-defensin 1 and 2 in secretory host defense system throughout respiratory tract of healthy rats were immunohistochemically investigated. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NCs) were immunopositive for both β-defensin 1 and 2, whereas a small number of goblet cells (GCs) were immunopositive only for β-defensin 1. Beta-defensin 2-immunopositive GCs were few. In the nasal glands, a small number of acinar cells and a large number of ductal epithelial cells were immunopositive for both β-defensins...
January 1, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29297499/differential-regulation-of-the-transcriptomic-and-secretomic-landscape-of-sensor-and-effector-functions-of-human-airway-epithelial-cells
#5
Roland Lehmann, Mario M Müller, Tilman E Klassert, Dominik Driesch, Magdalena Stock, Anina Heinrich, Theresia Conrad, Christoph Moore, Uta K Schier, Reinhard Guthke, Hortense Slevogt
Protein secretion upon TLR, TNFR1, and IFNGR ligation in the human airways is considered to be central for the orchestration of pulmonary inflammatory and immune responses. In this study, we compared the gene expression and protein secretion profiles in response to specific stimulation of all expressed TLRs and in further comparison to TNFR1 and IFNGR in primary human airway epithelial cells. In addition to 22 cytokines, we observed the receptor-induced regulation of 571 genes and 1,012 secreted proteins. Further analysis revealed high similarities between the transcriptional TLR sensor and TNFR1 effector responses...
January 3, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29296079/association-of-innate-defense-proteins-bpifa1-and-bpifb1-with-disease-severity-in-copd
#6
Elise G De Smet, Leen Jm Seys, Fien M Verhamme, Bart M Vanaudenaerde, Guy G Brusselle, Colin D Bingle, Ken R Bracke
Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal inflammatory response in the lungs caused by the inhalation of noxious particles and gases. The airway epithelium has a protective function against these harmful agents by maintaining a physical barrier and by secreting defensive proteins, such as bactericidal/permeability-increasing fold-containing (BPIF) proteins, BPIFA1 and BPIFB1. However, inconsistent data regarding BPIFA1 expression in smokers and COPD patients have been reported to date...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29288383/transcription-factors-regulating-embryonic-development-of-pulmonary-vasculature
#7
Craig Bolte, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Lung morphogenesis is a highly orchestrated process beginning with the appearance of lung buds on approximately embryonic day 9.5 in the mouse. Endodermally derived epithelial cells of the primitive lung buds undergo branching morphogenesis to generate the tree-like network of epithelial-lined tubules. The pulmonary vasculature develops in close proximity to epithelial progenitor cells in a process that is regulated by interactions between the developing epithelium and underlying mesenchyme. Studies in transgenic and knockout mouse models demonstrate that normal lung morphogenesis requires coordinated interactions between cells lining the tubules, which end in peripheral saccules, juxtaposed to an extensive network of capillaries...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29277683/new-aerosol-formulation-to-control-ciprofloxacin-pulmonary-concentration
#8
Barbara Lamy, Frederic Tewes, Dolores Remedios Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, Anne Marie Healy, Sandrine Marchand
Ciprofloxacin (CIP) apparent permeability across a pulmonary epithelium model can be controlled by the affinity of its complex with a metal cation. The higher the complex affinity, the larger is the reduction in CIP apparent permeability. The aim of this study was to evaluate if the control of the CIP apparent permeability observed in vitro could be transposed in vivo to control the CIP lung-to-blood absorption rate and CIP concentrations in the lung epithelial lining fluid (ELF) after intratracheal (IT) administration...
December 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29274832/extremely-preterm-fetal-sheep-lung-responses-to-antenatal-steroids-and-inflammation
#9
Kevin Visconti, Paranthaman Senthamaraikannan, Matthew W Kemp, Masatoshi Saito, Boris W Kramer, John P Newnham, Alan H Jobe, Suhas G Kallapur
BACKGROUND: The efficacy of antenatal steroids for fetal lung maturation in the peri-viable period is not fully understood. OBJECTIVE(S): To determine the lung maturational effects of ANS and inflammation in early gestation sheep fetuses, similar to the peri-viable period in humans. STUDY DESIGN: Date-mated ewes with singleton fetuses were randomly assigned to one of 4 treatment groups (n=8/group): 1) maternal intramuscular injection (IM) of betamethasone (Beta), 2) intra-amniotic lipopolysaccharide (IA) (LPS), 3) Beta+LPS, 4) IA+IM Saline (controls)...
December 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29239012/maintenance-of-equine-anaesthesia-over-the-last-50%C3%A2-years-controlled-inhalation-of-volatile-anaesthetics-and-pulmonary-ventilation
#10
REVIEW
M Mosing, J M Senior
In the first edition of this journal, Barbara Weaver wrote a review titled 'Equine Anaesthesia', stating that, at that time, it was quickly becoming accepted practice that many horses were being anaesthetised 'by essentially similar procedures, i.e. premedication, induction and then maintenance by controlled inhalation'. To celebrate the 50th anniversary of the first edition of this journal, this review covers the development of understanding and practice of inhalational anaesthesia and controlled ventilation in horses over the last 50 years...
December 14, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29235345/mucus-and-cell-penetrating-nanoparticles-embedded-in-nano-into-micro-formulations-for-pulmonary-delivery-of-ivacaftor-in-cystic-fibrosis
#11
Barbara Porsio, Emanuela Fabiola Craparo, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro
Here, mucus-penetrating nanoparticles for pulmonary administration of Ivacaftor in patients with cystic fibrosis (CF) were produced with the dual aim to enhance Ivacaftor delivery to the airway epithelial cells, by a rapid diffusion through the mucus barrier and, at the same time, promote Ivacaftor lung cellular uptake. Pegylated and Tat-decorated Fluorescent Nanoparticles (FNPs) were produced by nanoprecipitation, starting by two synthetic copolymers and showed nanometric sizes (~70 nm), slightly negative ζ potential and high cytocompatibility towards human bronchial epithelium cells...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29228935/dosimetrically-administered-nebulized-morphine-for-breathlessness-in-very-severe-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#12
Piotr Janowiak, Małgorzata Krajnik, Zygmunt Podolec, Tomasz Bandurski, Iwona Damps-Konstańska, Piotr Sobański, David C Currow, Ewa Jassem
BACKGROUND: Systemic morphine has evidence to support its use for reducing breathlessness in patients with severe chronic obstructive pulmonary disease (COPD). The effectiveness of the nebulized route, however, has not yet been confirmed. Recent studies have shown that opioid receptors are localized within epithelium of human trachea and large bronchi, a target site for a dosimetric nebulizer. The aim of this study was to compare any clinical or statistical differences in breathlessness intensity between nebulized 2...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29226951/cigarette-smoke-and-non-neuronal-cholinergic-system-in-the-airway-epithelium-of-copd-patients
#13
Angela Marina Montalbano, Caterina Di Sano, Giuseppina Chiappara, Loredana Riccobono, Anna Bonanno, Giulia Anzalone, Patrizio Vitulo, Loredana Pipitone, Mark Gjomarkaj, Michael P Pieper, Fabio Luigi Massimo Ricciardolo, Rosalia Paola Gagliardo, Mirella Profita
Acetylcholine (ACh), synthesized by Choline Acetyl-Transferase (ChAT), exerts its physiological effects via mAChRM3 in epithelial cells. We hypothesized that cigarette smoke affects ChAT, ACh, and mAChRM3 expression in the airways from COPD patients promoting airway disease. ChAT, ACh, and mAChRM3 were assessed: "ex vivo" in the epithelium from central and distal airways of COPD patients, Healthy Smoker (S) and Healthy Subjects (C), and "in vitro" in bronchial epithelial cells stimulated with cigarette smoke extract (CSE)...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29225322/immunohistochemical-study-on-the-secretory-host-defense-system-with-lysozyme-and-secretory-phospholipase-a2-throughout-rat-respiratory-tract
#14
Natsumi Masuda, Youhei Mantani, Chiaki Yoshitomi, Hideto Yuasa, Miho Nishida, Masaya Arai, Junichi Kawano, Toshifumi Yokoyama, Nobuhiko Hoshi, Hiroshi Kitagawa
The host defense system with lysozyme and secretory phospholipase A2 (sPLA2) was immunohistochemically investigated in rat respiratory tract under healthy conditions. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NC) and a small number of goblet cells (GC) were immunopositive for lysozyme and sPLA2. A few acinar cells and almost all epithelial cells of intercalated ducts were immunopositive for both bactericidal substances in the nasal glands. In the laryngeal and tracheal epithelia, few NC and GC were immunopositive for both bactericidal substances...
December 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29215731/eucalyptol-protects-lungs-against-bacterial-invasion-through-attenuating-ciliated-cell-damage-and-suppressing-muc5ac-expression
#15
Na Yu, Yi-Tian Sun, Xin-Ming Su, Miao He, Bing Dai, Jian Kang
This study was conducted to investigate whether Eucalyptol plays a role in influencing bacterial growth in cigarette smoke exposed lungs. Rats were exposed to air (control) and cigarette smoke (smoking) in presence and absence of Eucalyptol (260 mg/day). Morphological analysis of lung structures and status of airway mucous production were observed under a microscope. Pathological changes of ciliated columnar epithelium in airways were examined using transmission electron microscopy. MUC5AC protein and mRNA expression in bronchoalveolar lavage fluid (BALF) and lungs were determined...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29211494/exhaustion-of-airway-basal-progenitor-cells-in-early-and-established-copd
#16
Moumita Ghosh, York E Miller, Ichiro Nakachi, Jennifer B Kwon, Anna E Barón, Alexandra E Brantley, Daniel T Merrick, Wilbur A Franklin, Robert L Keith, R William Vandivier
RATIONALE: Up to 40% of smokers develop chronic obstructive pulmonary disease (COPD) over a period that spans decades. Despite the importance of COPD, much remains to be learned about susceptibility and pathogenesis, especially during early, pre-diagnostic stages of disease. Airway basal progenitor cells are crucial for lung health and resilience, because of their ability to repair injured airways. In COPD, the normal airway epithelium is replaced with increased basal and secretory (mucous) cells and decreased ciliated cells, suggesting that progenitors are impaired...
December 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29207030/der-f1-induces-pyroptosis-in-human-bronchial-epithelia-via-the-nlrp3-inflammasome
#17
Ying-Ming Tsai, Kuo-Hwa Chiang, Jen-Yu Hung, Wei-An Chang, Hui-Ping Lin, Jiunn-Min Shieh, Inn-Wen Chong, Ya-Ling Hsu
Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase release and propidium iodide penetration...
December 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29199880/exposure-to-cigarette-smoke-extract-and-lipopolysaccharide-modifies-cytoskeleton-organization-in-bronchial-epithelial-cells
#18
Claudia D'Anna, Diego Cigna, Caterina Di Sano, Serena Di Vincenzo, Paola Dino, Maria Ferraro, Luca Bini, Laura Bianchi, Francesca Di Gaudio, Mark Gjomarkaj, Elisabetta Pace
The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differentially expressed proteins in a bronchial epithelial cell line (16-HBE) stimulated with cigarette smoke extract (CSE) and lipopolysaccharide (LPS), a constituent of gram-negative bacteria, alone and/or in combination, by using two-dimensional electrophoresis (2DE) analysis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
December 4, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29199537/equine-renal-hemangiosarcoma-clinical-presentation-pathologic-features-and-pstat3-expression
#19
Katherine Hughes, Victoria H L Scott, Maximilian Blanck, Timothy P Barnett, Jannie Spanner Kristiansen, Alastair K Foote
Hemangiosarcoma is an uncommon tumor in horses. We characterized 3 cases of equine renal hemangiosarcoma, focusing on clinical and pathologic features, and describe occurrence of the epithelioid variant of hemangiosarcoma in one of these cases. Nuclear expression of phosphorylated STAT3 (pSTAT3) was assessed to analyze potential inappropriate STAT3 activation as a component of tumor pathogenesis. Clinical signs in the 3 horses included insidious weight loss, followed in one case by serosanguineous nasal discharge and terminal epistaxis, and nonspecific signs of abdominal pain...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29191716/pulmonary-absorption-estimation-of-effective-pulmonary-permeability-and-tissue-retention-of-ten-drugs-using-an-ex-vivo-rat-model-and-computational-analysis
#20
Johanna Eriksson, Erik Sjögren, Helena Thörn, Katarina Rubin, Per Bäckman, Hans Lennernäs
Permeation of inhaled drugs across the pulmonary epithelium can regulate the rate and extent of local drug absorption and hence the pulmonary tissue concentration. Therefore, understanding pulmonary epithelial transport could be important for successful design of novel inhaled medicines. To enhance understanding of pulmonary epithelial transport, drug transport data were generated for a set of inhaled compounds (n=10) in the single-pass, isolated perfused rat lung model. A compartmental in silico model was used to estimate pulmonary permeability and tissue retention...
November 27, 2017: European Journal of Pharmaceutics and Biopharmaceutics
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