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Celiac hypothyroidism

Hale Tuhan, Sakine Işık, Ayhan Abacı, Erdem Şimşek, Ahmet Anık, Özden Anal, Ece Böber
AIM: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT). MATERIAL AND METHODS: The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded...
June 2016: Türk Pediatri Arşivi
Verônica Medeiros da Costa, Patricia de Carvalho Padilha, Géssica Castor Fontes de Lima, Aline Alves Ferreira, Jorge Luiz Luescher, Luciana Porto, Wilza Arantes Ferreira Peres
OBJECTIVES: Describe the overweight frequency (overweight and obesity) and identify the factors associated with this in children and adolescents with type 1 diabetes mellitus (T1DM) treated at a University Children's Hospital in Rio de Janeiro. METHODS: This is an analytical cross-sectional study, which included patients diagnosed with T1DM who had complete anthropometric data (weight and height) and excluded those using drugs with effect on weight gain, genetic syndromes, celiac disease, hypothyroidism, renal failure and other chronic diseases, and pregnant women...
2016: Diabetology & Metabolic Syndrome
Şükrü Hatun, Hüseyin Demirbilek, Şükran Darcan, Ayşegül Yüksel, Cigdem Binay, Damla Gökşen Şimşek, Cengiz Kara, Ergun Çetinkaya, Tolga Ünüvar, Ahmet Uçaktürk, Filiz Tütüncüler, Yaşar Cesur, Ruveyde Bundak, Halil Sağlam, Enver Şimşek, Abdullah Bereket
AIMS: To evaluate the management strategies, glycemic control and complications of pediatric type 1 diabetes mellitus (T1DM) patients in Turkey. METHODS: Study included 498 patients with T1DM between the ages 1-18. Data provided from patients' hospital files were recorded on standard case report forms by applicant clinicians within the 3months of data collection period between October 2012 and July 2013. RESULTS: Mean age of patients was 11...
September 2016: Diabetes Research and Clinical Practice
Surinder S Rana, Arvind Dambalkar, Puneet Chhabra, Ravi Sharma, Ritambhra Nada, Vishal Sharma, Satyavati Rana, Deepak K Bhasin
BACKGROUND: Although exocrine pancreatic insufficiency (EPI) has been reported in a number of patients with celiac disease (CD), it is not clear if this is primarily a functional or a structural defect. We studied pancreatic structural abnormalities by endoscopic ultrasound (EUS) in adult CD patients with EPI. METHODS: Pancreatic exocrine function was prospectively assessed in 36 recently diagnosed CD patients (mean age: 29.8 years) by measuring fecal elastase. Pancreatic structural changes were assessed in CD patients with EPI by EUS and elastography...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Dan Carter, Marc Beer-Gabel, Estela Derazne, Dorit Tzur, Eytan Bardan
BACKGROUND AND AIMS: The diagnosis of irritable bowel syndrome (IBS) is based mainly on clinical evaluation. The reported incidence of misclassification of significant organic diseases in previously diagnosed IBS patients differs between studies. The aim of this study was to examine the incidence and risk factors for the misclassification of significant organic disease [colon cancer, inflammatory bowel disease (IBD), Celiac disease, and thyroid dysfunction] in a cohort of young patients with symptoms attributed to IBS...
June 24, 2016: Journal of Clinical Gastroenterology
Abhik Roy, Monika Laszkowska, Johan Sundström, Benjamin Lebwohl, Peter H R Green, Olle Kämpe, Jonas F Ludvigsson
BACKGROUND: Several screening studies have indicated an increased prevalence of celiac disease (CD) among individuals with autoimmune thyroid disease (ATD), but estimates have varied substantially. OBJECTIVE: The aim of this study was to examine the prevalence of CD in patients with ATD. METHOD: A systematic review was conducted of articles published in PubMed Medline or EMBASE until September 2015. Non-English papers with English-language abstracts were also included, as were research abstracts without full text available when relevant data were included in the abstract...
July 2016: Thyroid: Official Journal of the American Thyroid Association
Cristina Canova, Gisella Pitter, Jonas F Ludvigsson, Pierantonio Romor, Loris Zanier, Renzo Zanotti, Lorenzo Simonato
OBJECTIVES: To estimate the relative risk of developing type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease in children with celiac disease (CD). STUDY DESIGN: A matched cohort design with linkage of administrative data was adopted. A total of 1215 cases of CD and 6075 references matched by sex and year of birth born in Friuli Venezia Giulia Region (Italy) between 1989 and 2011 were included. Cox regression models were used to estimate hazard ratios (HRs) for autoimmune diseases in patients with CD compared with references, stratified by sex and age at diagnosis...
July 2016: Journal of Pediatrics
Barbara Szepietowska, Natalia Wawrusiewicz-Kurylonek, Adam Krętowski, Maria Górska, Małgorzata Szelachowska
INTRODUCTION: Latent autoimmune diabetes in adults (LADA) is a slow-developing form of autoimmune diabetes, characterised by the presence of type 1 diabetes-associated autoantibody and presentation at diagnosis similar to patients with type 2 diabetes. The aim of this study was to determine the prevalence of auto-antibodies related to endocrine autoimmune diseases in patients with LADA and to assess their association with HLA genotype. MATERIAL AND METHODS: We evaluated the presence of anti-thyroglobulin (ATG), anti-thyroid peroxidase (ATPO), anti-tissue transglutaminase IgA (ATTA), and anti 21 hydroxylase (A21H) in 70 patients with LADA, 69 with Type 2 diabetes, and in 50 healthy controls HLA genotype was assed in subpopulation of sluclied subjects...
2016: Endokrynologia Polska
Ganesh Jevalikar, Chhavi Kohli, Beena Bansal, Sunil Kumar Mishra, Jasjeet Singh Wasir, Shweta Singh, Jasmine Kaur Ahuja, Parjeet Kaur, Khalid J Farooqui, Ambrish Mithal
OBJECTIVES: To identify proportion of various types of diabetes and differences between type 1 and type 2 diabetes in patients with youth onset diabetes (onset below 25 completed years of age). In addition, concurrent autoimmune diseases in type 1 diabetes were studied in a subset of patients. METHODS: A total of 577 patients (192 girls) with diabetes onset at median age of 14 y (range 1 mo-25 y) with median duration of 1 y (range day of diagnosis- 43 y) were included...
August 2016: Indian Journal of Pediatrics
Khosro Farhad, Rebecca Traub, Katherine M Ruzhansky, Thomas H Brannagan
INTRODUCTION: The etiology of neuropathy was idiopathic in 20%-30% of patients despite thorough investigation, based on results from the 1980s and 1990s. Since then, new etiologies have been recognized, and skin biopsy has been used to confirm small-fiber neuropathy. METHODS: The authors reviewed the charts of 373 patients with idiopathic neuropathy who were referred to a neuropathy center between 2002 and 2012. RESULTS: Among the 284 eligible patients, 93 (32...
June 2016: Muscle & Nerve
Aldo Ferreira-Hermosillo, Mario Antonio Molina-Ayala
Type 1A diabetes (DM1A) is an autoimmune disease that comprises 10% of patients with diabetes mellitus. Its frequency is gradually increasing in countries like Mexico. Patients with DM1A commonly have hypothyroidism, Addison disease, celiac disease and less common diseases such as polyglandular syndrome. These diseases are related to susceptibility genes such as HLA, CTLA-4 and PTPN22, which induce central and peripheral immunologic tolerance. This review article emphasizes the importance of searching other autoimmune diseases in patients with DM1A, to improve their prognosis and quality of life...
August 2015: Revista Médica de Chile
Richard Zubarik, Eric Ganguly, Muriel Nathan, James Vecchio
BACKGROUND: Celiac disease (CD) is associated with hypothyroidism, but the disease prevalence is not thought to be great enough to warrant testing all hypothyroid patients. We hypothesized that hypothyroid patients with concomitant CD would require elevated doses of levothyroxine, and there is a threshold daily dose, above which, hypothyroid patients should be tested for CD. METHODS: Hypothyroid patients presenting to the endoscopy or endocrinology clinics at the University of Vermont Medical Center were included...
December 2015: European Journal of Internal Medicine
Branka Kovačev-Zavišić, Tijana Ičin, Jovanka Novaković-Paro, Milica Medić-Stojanoska, Ivana Bajkin
INTRODUCTION: Secondary osteoporosis occurs in many diseases. Celiac disease-induced osteoporosis is the consequence of secondary hyperparathyroidism. Biochemical bone markers show predominance of bone resorption, thus making the bisphosphonates the first line therapy option. Intestinal mucosal changes are reversible on gluten-free diet. Osteoporosis reversibility is also possible, provided postmenopausal osteoporosis risk factors independent from celiac disease are not present. CASE REPORT: We presented a postmenopausal woman with at least a 10-year history of celiac disease prior to diagnosis, which had overt secondary hyperparathyroidism with insufficient status of vitamin D and a significant bone mass reduction...
January 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Manoj Lakhotia, Hans Raj Pahadia, Harish Kumar, Jagdish Singh, Sandeep Tak
Autoimmune Polyglandular syndrome (APS) are rare condition characterised by presence of immune dysfunction of two or more endocrine glands and other non-endocrine organs. APS is divided into 2 major subtypes based on age of presentation, pattern of disease combinations and mode of inheritance. APS 1(juvenile) usually manifest in early adolescence or in infancy. It is characterised by multiple endocrinal deficiency with mucocutaneous candidiasis and ectodermal dystrophy. Of the endocrine diseases, hypoparathyroidism form an important component followed by Addison's disease, type 1A diabetes, hypogonadism and thyroid disease...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
Anju Virmani
Though children with type 1 diabetes mellitus (T1DM) are often tall at the time of diagnosis, they may experience growth retardation, pubertal delay or both, which may be due to poor glycemic control, associated diseases or chronic complications. Factors affecting growth include: gender, genetic environment, age at diagnosis, diabetes duration, puberty, metabolic control, and status of growth hormone (GH), insulin-like growth factors (IGFs), and IGF binding proteins (IGFBPs). Insulin regulates expression of hepatic GH receptors, affects IGFs and IGFBPs synthesis by modulating GH postreceptor events, and significantly increases IGF-I bioactivity...
April 2015: Indian Journal of Endocrinology and Metabolism
Derya Kalyoncu, Nafiye Urganci
Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up...
2015: International Journal of Endocrinology
Louise Emilsson, Cisca Wijmenga, Joseph A Murray, Jonas F Ludvigsson
BACKGROUND & AIMS: First-degree relatives of individuals with celiac disease are at increased risk for this disorder, but little is known about their risk for other autoimmune diseases. We assessed the risk of nonceliac autoimmune disease in first-degree relatives and spouses of people with celiac disease. METHODS: We identified individuals with celiac disease by searching computerized duodenal and jejunal biopsies, collected from 1969 through 2008, at 28 pathology departments in Sweden...
July 2015: Clinical Gastroenterology and Hepatology
Anna Kawicka, Bożena Regulska-Ilow, Bożena Regulska-Ilow
In recent years, the authors of epidemiological studies have documented that autoimmune diseases are a major problem of modern society and are classified as diseases of civilization. Autoimmune thyroid diseases (ATDs) are caused by an abnormal immune response to autoantigens present in the thyroid gland - they often coexist with other autoimmune diseases. The most common dysfunctions of the thyroid gland are hypothyroidism, Graves-Basedow disease and Hashimoto's disease. Hashimoto's thyroiditis can be the main cause of primary hypothyroidism of the thyroid gland...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
Hannah M A Robertson, Anil K P Narayanaswamy, Olivia Pereira, Shirley A Copland, Richard Herriot, Alistair W McKinlay, John S Bevan, Prakash Abraham
BACKGROUND: While few hypothyroid patients require more than the expected weight-related dose of levothyroxine, the underlying causes of larger-than-expected dosing requirements have not been studied in a single cohort. Our aim was to determine and quantify the multiple factors contributing to high-dose levothyroxine requirements in a cohort of patients with hypothyroidism. METHODS: The Grampian Automated Follow-Up Register (GAFUR) monitors around 17,500 hypothyroid patients...
December 2014: Thyroid: Official Journal of the American Thyroid Association
Stefano Stagi, Donato Rigante, Gemma Lepri, Federico Bertini, Marco Matucci-Cerinic, Fernanda Falcini
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are basically characterized by obsessive-compulsive symptoms and/or tics triggered by group-A beta-hemolytic Streptococcus infections. Poor data are available about the clear definition of PANDAS's autoimmune origin. The aim of our study was to evaluate the prevalence of autoimmune phenomena, including thyroid function abnormalities, specific celiac disease antibodies, and positivity of organ- or nonorgan-specific autoantibodies in a large cohort of Caucasian children and adolescents with PANDAS...
December 2014: Autoimmunity Reviews
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