keyword
MENU ▼
Read by QxMD icon Read
search

Formulations

keyword
https://www.readbyqxmd.com/read/29161602/gravel-beaches-nourishment-modelling-the-equilibrium-beach-profile
#1
I López, L Aragonés, Y Villacampa, F J Navarro-González
The erosion of the world's coasts and the shortage of sand to mitigate beach erosion are leading to the increasingly common use of gravel for coastal protection and beach nourishment. Therefore, in order to determine the amount of gravel required for such actions, it is important to know perfectly the equilibrium profile of gravel beaches. However, at present, this profile is obtained from formulas obtained mainly after channel tests, and therefore most of them do not adapt to the real profiles formed by gravel beaches in nature...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161531/pulmonary-safety-and-tolerability-of-inhaled-levodopa-cvt-301-administered-to-patients-with-parkinson-s-disease
#2
Peter A LeWitt, Rajesh Pahwa, Alexander Sedkov, Ann Corbin, Richard Batycky, Harald Murck
BACKGROUND: CVT-301, an inhaled levodopa (LD) formulation, is under development for relief of OFF periods in Parkinson's disease (PD). Previously, we reported that CVT-301 improved OFF symptoms relative to placebo. In this study, we evaluate pulmonary function in patients treated with a single dose of CVT-301 or placebo for 3 hours, or received multiple doses/day for 4 weeks. METHODS: As part of two phase 2 studies, pulmonary safety and tolerability of CVT-301 were evaluated in PD patients experiencing motor fluctuations (≥2 hours OFF/day), Hoehn and Yahr stage 1-3, and forced expiratory volume in 1 second/forced vital capacity ratio ≥75% of predicted (in ON state)...
November 21, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29161509/variation-in-the-supersaturation-and-phase-behavior-of-ezetimibe-amorphous-solid-dispersions-upon-dissolution-in-different-biorelevant-media
#3
Ahmed Elkhabaz, Sreya Sarkar, Janny K Dinh, Garth J Simpson, Lynne S Taylor
The delivery of poorly water-soluble drugs using amorphous solid dispersions (ASDs) has been widely acknowledged as a promising strategy for enhancing oral bioavailability. Upon dissolution, ASDs have accelerated dissolution rates and yield supersaturated solutions leading to higher apparent solubilities. Understanding the complex phase behavior of ASDs during dissolution is crucial for developing an effective formulation. Since the absorption of a lipophilic, high permeability drug is determined primarily by the intraluminal dissolution process and the final concentration achieved, there is a need for evaluation in biorelevant dissolution media that simulate both fasting and fed gastrointestinal states...
November 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29161185/medications-for-sleep-schedule-adjustments-in-athletes
#4
Matthew B Baird, Irfan M Asif
CONTEXT: Sleep schedule adjustments are common requirements of modern-day athletes. Many nonpharmacologic and pharmacologic strategies exist to facilitate circadian rhythm shifts to maximize alertness and performance during competition. This review summarizes the evidence for commonly used pharmacologic agents and presents recommendations for the sports medicine provider. EVIDENCE ACQUISITION: MEDLINE searches were performed using the following keywords: sleep aids, circadian rhythm adjustment, athletes and sleep, caffeine and sports, melatonin and athletes, and sleep aids and sports...
November 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29161092/the-impact-of-diet-on-immunity-and-respiratory-diseases
#5
Tomasz P Wypych, Benjamin J Marsland, Niki D J Ubags
The Western world has witnessed a tremendous increase in the occurrence of allergy and autoimmunity in the second half of the 20th century. Extensive efforts have been made to explain this phenomenon and various hypotheses have been formulated. Among them, two concepts have attracted the most attention: the "hygiene hypothesis," identifying the reduced exposure to environmental microorganisms as a driving force behind the observed epidemiological trends; and the "diet hypotheses," pointing to the importance of changes in our dietary habits...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29161059/american-doctors-at-the-nuremberg-medical-trial
#6
Evelyne Shuster
Three Hippocratic physicians played critical roles in the prosecution of 23 Nazi doctors charged with murder and torture for conducting lethal medical experiments on concentration camp prisoners. Two of the physicians, Leopold Alexander and Andrew C. Ivy, were Americans, and the other, Werner Leibbrandt, was German. At the 70th anniversary of the Doctors' Trial it is fitting to recall the three's influences and contributions to the formulation of strict research ethics rules, known as the Nuremberg Code. Their contributions help us better understand why they insisted on strict research rules and yet ultimately were unable to apply these rules to their own research...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161026/conditional-reversible-work-coarse-grained-models-of-molecular-liquids-with-coulomb-electrostatics-a-proof-of-concept-study-on-weakly-polar-organic-molecules
#7
Gregor Deichmann, Nico F A van der Vegt
Scale bridging simulations of soft matter rely on the availability of transferable coarse-grained models. In systematic coarse-graining approaches, core principles of statistical mechanics are used to relate the coarse-grained models to the underlying molecular interactions. The conditional reversible work (CRW) method provides effective, nonbonded pair potentials by means of computing coupling free energies between mapped chemical groups. This method has so far been used almost exclusively for systems composed of apolar organic molecules, but additional challenges arise when developing coarse-grained models for polar molecules in which (long-ranged) electrostatic interactions are important...
November 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29160917/visualization-of-calcium-phosphate-cement-in-teeth-by-zero-echo-time-1-h-mri-at-high-field
#8
Weiqiang Dou, Simone Mastrogiacomo, Andor Veltien, Hamdan S Alghamdi, X Frank Walboomers, Arend Heerschap
(1) H magnetic resonance imaging (MRI) by a zero echo time (ZTE) sequence is an excellent method to image teeth. Calcium phosphate cement (CPC) materials are applied in the restoration of tooth lesions, but it has not yet been investigated whether they can be detected by computed tomography (CT) or MRI. The aim of this study was to optimize high-field ZTE imaging to enable the visualization of a new CPC formulation implanted in teeth and to apply this in the assessment of its decomposition in vivo. CPC was implanted in three human and three goat teeth ex vivo and in three goat teeth in vivo...
November 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29160839/inkjet-printing-of-drug-loaded-mesoporous-silica-nanoparticles-a-platform-for-drug-development
#9
Henrika Wickström, Ellen Hilgert, Johan O Nyman, Diti Desai, Didem Şen Karaman, Thomas de Beer, Niklas Sandler, Jessica M Rosenholm
Mesoporous silica nanoparticles (MSNs) have shown great potential in improving drug delivery of poorly water soluble (BCS class II, IV) and poorly permeable (BCS class III, IV) drugs, as well as facilitating successful delivery of unstable compounds. The nanoparticle technology would allow improved treatment by reducing adverse reactions of currently approved drugs and possibly reintroducing previously discarded compounds from the drug development pipeline. This study aims to highlight important aspects in mesoporous silica nanoparticle (MSN) ink formulation development for digital inkjet printing technology and to advice on choosing a method (2D/3D) for nanoparticle print deposit characterization...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29160824/microneedle-assisted-percutaneous-delivery-of-a-tetramethylpyrazine-loaded-microemulsion
#10
Qiang Zu, Yanyan Yu, Xiaolin Bi, Ren Zhang, Liuqing Di
This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN). The TMP-ME formulation was optimized in vitro with skin permeation experiments, using a uniform experimental design, guided by a pseudo-ternary phase diagram, in which the TMP skin permeation level and mean particle size were indices. The effects of MN pretreatment on skin permeation by TMP-ME were assessed using in vitro skin permeation, in vivo skin microdialysis, and pharmacokinetic studies in rats...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29160818/effect-of-different-skin-penetration-promoters-in-halobetasol-propionate-permeation-and-retention-in-human-skin
#11
Paulina Carvajal-Vidal, Mireia Mallandrich, María Luisa García, Ana Cristina Calpena
Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160732/optimization-and-characterization-of-sertaconazole-nitrate-flexisomes-embedded-in-hydrogel-for-improved-antifungal-activity
#12
Satish K Mandlik, Shridhar S Siras, Kiran R Birajdar
The aim of the present research work was to develop, characterize and optimize sertaconazole nitrate (STZN) embedded flexisomes (STZN-FS) to improve the cutaneous anti-fungal activity of STZN. Flexisomes are self-aggregating, flexible, deformable lipidic vesicles possessing an aqueous core. A 3(2) factorial design was implemented to optimize the effects of the critical material attributes of concentration of phospholipid (X1) and edge activator (X2) on the critical quality attributes of particle size (Y1), entrapment efficiency (Y2) and deformability index (Y3)...
November 21, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29160685/graphene-oxide-a-new-carrier-for-slow-release-of-plant-micronutrients
#13
Shervin Kabiri, Fien Degryse, Diana N H Tran, Rodrigo da Silva, Michael J McLaughlin, Dusan Losic
The environmental problems and low efficiency associated with conventional fertilizers provides an impetus to develop advanced fertilizers with slower release and better performances. Here we report of development of a new carrier platform based on graphene oxide (GO) sheets that can provide a high loading of plant micronutrients with controllable slow release. To prove this concept two micronutrients zinc (Zn) and copper (Cu) were used to load on GO sheets and hence formulate GO-based micronutrients fertilizer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160627/native-and-microwave-modified-terminalia-mantaly-gums-as-sustained-release-and-bioadhesive-excipients-in-naproxen-matrix-tablet-formulations
#14
Michael Ayodele Odeniyi, Babatunde Mukhtar Oyedokun, Oluyemisi Adebowale Bamiro
BACKGROUND: Hydrophilic polymers provide a means of sustaining drug delivery. Native gums may be limited in function, but modification may improve their activity. OBJECTIVES: The aim of the study was to evaluate native and modified forms of Terminalia mantaly gum for their sustained-release and bioadhesive properties. MATERIAL AND METHODS: The native gum (NTM) was modified by microwave irradiation for 20 seconds (MTM20) and 60 seconds (MTM60) and characterized using microscopy, Fourier transform infrared spectroscopy (FTIR) and packing properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160626/film-forming-properties-of-cissus-pulpunea-guill-and-perr-and-irvingia-gabonensis-o-rorke-gums
#15
Tolulope Omolola Ajala, Hope Idemudia Olaiya, Oluwatoyin Adepeju Odeku
BACKGROUND: Natural polymers such as gums have gained attention in drug delivery systems due to their availability, compatibility and degradation under natural and physiological conditions. OBJECTIVES: The aim of the present study was to investigate the film forming properties of gums obtained from the stem of Cissus polpunea (Guill and Perr) and the seed of Irvingia gabonensis (O'Rorke). MATERIAL AND METHODS: Gums were extracted from the relevant plant parts and characterized using functional, proximate and elemental properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160625/evaluation-of-two-novel-plant-gums-for-bioadhesive-microsphere-and-sustained-release-formulations-of-metformin-hydrochloride
#16
John Oluwasogo Ayorinde, Michael Ayodele Odeniyi, Arvind K Bansal
BACKGROUND: The biological half life of metformin requires multiple doses which are associated with poor patient compliance. This justifies the need for a dosage form with reduced dosing frequency. OBJECTIVES: Gums from Enterolobium cyclocarpum and Cedrela odorata trees were evaluated in formulating bioadhesive microspheres containing metformin hydrochloride, for sustained drug release. Hydroxylpropylmethyl cellulose (HPMC) was the standard. MATERIAL AND METHODS: Microspheres were produced from formulations of API and either cedrela gum (FC), enterolobium gum (FE) or HPMC (FH), using a W/O solvent extraction technique...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160624/buccal-patches-of-atenolol-formulated-using-fenugreek-trigonella-foenum-graecum-l-seed-mucilage
#17
Surya Narayan Ratha Adhikari, Satyabrata Panda
BACKGROUND: The use of mucoadhesive natural polymers in designing mucoadhesive patch systems has received much attention. OBJECTIVES: The study involved the development and evaluation of buccal patches of atenolol using fenugreek (Trigonella foenum-graecum L.) seed mucilage with hydroxylpropyl methyl cellulose (HPMC K4M) and a backing membrane (ethyl cellulose 5% w/v). MATERIAL AND METHODS: These atenolol-releasing buccal patches were prepared using a solvent casting technique...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160495/systemic-arterial-hypertension-in-people-living-with-hiv-aids-integrative-review
#18
Maria Amanda Correia Lima, Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão, Ryvanne Paulino Rocha, Kátia Barbosa Franco, Marina Soares Monteiro Fontenele
OBJECTIVE: To analyze scientific productions about the relationship between HIV and Systemic Arterial Hypertension (SAH) in people living with HIV/AIDS (PLWHA). METHOD: Integrative literature review in six databases, held in March 2016. "AIDS" and "hypertension" were the keywords used in Portuguese, English and Spanish languages. We found 248 articles and selected 17. The categories formulated were "prevalence of SAH in PLWHA," "risk factors for SAH in PLWHA" and "adverse events of antiretroviral therapy (ART) that contribute to HAS...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160391/agnps-the-new-allies-against-s-mutans-biofilm-a-pilot-clinical-trial-and-microbiological-assay
#19
Priscila L L Freire, Allan J R Albuquerque, Fabio C Sampaio, André Galembeck, Miguel A P Flores, Thayza C M Stamford, Aronita Rosenblatt
The purpose of this study was to evaluate the antimicrobial properties of a new formulation containing silver nanoparticles, named Nano Silver Fluoride (NSF), to inhibit Streptococcus mutans biofilm formation on children's dental enamel. The variations in dental biofilm pH and in the Simplified-Oral-Hygiene-Index (OHI-S) also were evaluated after the treatment with NSF. This was a randomized, double-blind, crossover and prospective pilot clinical trial study in which 12 schoolchildren, aged between 7-8 years, had their dental enamel treated with two solutions: S1 - Nano Silver Fluoride and S2 - negative control (saline solution), in different experimental moments...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160189/after-fertility-s-nadir-ethnic-differentials-in-parity-specific-behaviours-in-kyrgyzstan
#20
Thomas Spoorenberg
After a swift decline in the 1990s, the countries of Central Asia have experienced significant fertility increases over the last 15 years. These fertility upturns have remained off the radar of demographers. This study examines the recent fertility increase in Kyrgyzstan, focusing on fertility development by parity and among the main ethnic groups, in order to go beyond classic fertility indicators and national averages. Using a sample from the 2009 Census micro-dataset, sibling progression ratios were computed using information on the relationships and dates of birth of children under the age of 15...
November 2017: Journal of Biosocial Science
keyword
keyword
49643
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"