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József Sóki, Maria Hedberg, Sheila Patrick, Balázs Bálint, Róbert Herczeg, István Nagy, David W Hecht, Elisabeth Nagy, Edit Urbán
OBJECTIVES: The aim of this study was to examine the antibiotic resistance profiles, antibiotic resistance mechanisms and possible 'clonal' nature of some MDR Bacteroides fragilis strains that simultaneously harboured cfiA, nimB, IS1186 and IS4351. METHODS: Antibiotic susceptibilities were determined by Etests and antibiotic resistance genes and different genetic elements were detected by applying PCR methods. The environments of the cfiA and nimB genes were also determined by sequencing...
September 2016: Journal of Antimicrobial Chemotherapy
Gajendra B Baktavachalam, Bryan Delaney, Tracey L Fisher, Gregory S Ladics, Raymond J Layton, Mary Eh Locke, Jean Schmidt, Jennifer A Anderson, Natalie N Weber, Rod A Herman, Steven L Evans
Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) or the Herculex®(#) I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization...
2015: GM Crops & Food
Nina Ank, Thomas V Sydenham, Lene H Iversen, Ulrik S Justesen, Mikala Wang
Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.
July 2015: International Journal of Antimicrobial Agents
Clarisse Dupin, Zohreh Tamanai-Shacoori, Elodie Ehrmann, Anais Dupont, Frédérique Barloy-Hubler, Latifa Bousarghin, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon
Many β-lactamases have been described in various Gram-negative bacilli (Capnocytophaga, Prevotella, Fusobacterium, etc.) of the oral cavity, belonging to class A of the Ambler classification (CepA, CblA, CfxA, CSP-1 and TEM), class B (CfiA) or class D in Fusobacterium nucleatum (FUS-1). The minimum inhibitory concentrations of β-lactams are variable and this variation is often related to the presence of plasmids or other mobile genetic elements (MGEs) that modulate the expression of resistance genes. DNA persistence and bacterial promiscuity in oral biofilms also contribute to genetic transformation and conjugation in this particular microcosm...
February 2015: International Journal of Antimicrobial Agents
Thomas Vognbjerg Sydenham, József Sóki, Henrik Hasman, Mikala Wang, Ulrik Stenz Justesen
Bacteroides fragilis constitutes the most frequent anaerobic bacterium causing bacteremia in humans. The genetic background for antimicrobial resistance in B. fragilis is diverse with some genes requiring insertion sequence (IS) elements inserted upstream for increased expression. To evaluate whole genome shotgun sequencing as a method for predicting antimicrobial resistance properties, one meropenem resistant and five multidrug-resistant blood culture isolates were sequenced and antimicrobial resistance genes and IS elements identified using ResFinder 2...
February 2015: Anaerobe
Rosemary Meggersee, Valerie Abratt
Bacteroides fragilis, an anaerobic gut commensal and opportunistic pathogen, is a leading cause of anaerobic abscesses and bacteraemias. Treatment of infections is complicated by the emergence of resistance to several of the antibiotics used in the clinical setting. Genetic analysis of 23 B. fragilis isolates found that none of the metronidazole resistant strains carried the nimA-J genes, and no cfxA or ermF genes were detected. All of the tetracycline resistant isolates contained the tetQ gene and were sensitive to tigecycline...
April 2015: Anaerobe
Edit Székely, Zsuzsa Eitel, Szabolcs Molnár, Izabella Éva Szász, Doina Bilca, József Sóki
As part of an ESCMID Study Group on Anaerobic Infections (ESGAI) project, a study was conducted to measure the antibiotic susceptibilities and corresponding gene contents of 53 Bacteroides fragilis group strains isolated in Romania. The antibiotic resistance data was comparable with the data found for other East-European countries. Here, no resistant isolate was found for imipenem, metronidazole and tigecycline. An increasing role of the cepA, cfxA and cfiA genes was observed in their corresponding antibiotic resistances...
February 2015: Anaerobe
Laura Fitzpatrick, JoAnne Arcand, Mary L'Abbe, Mengying Deng, Tara Duhaney, Norm Campbell
The accuracy of the Nutrition Facts table (NFt) has a significant impact on Canadian efforts to reduce dietary sodium and monitor sodium content in foods. This study assessed the accuracy of sodium (and calories, trans fat, saturated fat, sugar) reported on the NFt for selected foods and beverages in Canada. The Canadian Food Inspection Agency (CFIA) sampled over 1000 foods and beverages from supermarkets, bakeries, and restaurants across Canada between January 2006 and December 2010. The samples were analyzed in CFIA laboratories...
August 2014: Nutrients
Åsa Johansson, Elisabeth Nagy, József Sóki
Rapid identification of isolates in positive blood cultures are of great importance to secure correct treatment of septicaemic patients. As antimicrobial resistance is increasing, rapid detection of resistance is crucial. Carbapenem resistance in Bacteroides fragilis associated with cfiA-encoded class B metallo-beta-lactamase is emerging. In our study we spiked blood culture bottles with 26 B. fragilis strains with various cfiA-status and ertapenem MICs. By using main spectra specific for cfiA-positive and cfiA-negative B...
August 2014: Journal of Medical Microbiology
Asa Johansson, Elisabeth Nagy, József Sóki
Today resistance against carbapenems is considered an emerging problem in Bacteroides fragilis. Carbapenemase activities produced by aerobic bacteria have been detected by looking at hydrolysis of carbapenems with MALDI-TOF MS, but this technique was never used for anaerobic bacteria. We have developed a protocol for detection and verification of carbapenemase production in B. fragilis within 2.5 h. Twenty-eight strains of B. fragilis were tested. Of the sixteen cfiA-positive strains all showed hydrolysis of ertapenem, whereas the twelve cfiA-negative strains showed no hydrolysis...
April 2014: Anaerobe
Ning Ding, Norman F Neumann, Luke M Price, Shannon L Braithwaite, Aru Balachandran, Miodrag Belosevic, Mohamed Gamal El-Din
Disposal of tissues and organs associated with prion accumulation and infectivity in infected animals (designated as Specified Risk Materials [SRM]) is strictly regulated by the Canadian Food Inspection Agency (CFIA); however, the contamination of wastewater from slaughterhouses that handle SRM still poses public concern. In this study, we examined for the first time the partitioning of infectious prions in rendering plant wastewater and found that a large proportion of infectious prions were partitioned into the scum layer formed at the top after gravity separation, while quite a few infectious prions still remained in the wastewater...
February 1, 2014: Science of the Total Environment
Mireia Orgilés, José P Espada
BACKGROUND: The Children's Somatization Inventory (CSI) has proved to be a suitable measure to assess somatic symptoms in pediatric patients, but additional research was needed to evaluate its psychometric properties in community populations. PURPOSE: The objective of the present study was to examine psychometric properties and factorial structure of the instrument among a nonclinical sample of Spanish children. METHOD: The 24-item version of the CSI and two self-report measures of anxiety and depression were administered to 1,111 Spanish children aged 8 to 12...
June 2014: International Journal of Behavioral Medicine
Rodney P Joseph, Kathryn E Royse, Tanya J Benitez, Dorothy W Pekmezi
PURPOSE: Physical activity (PA) has been shown to enhance quality of life (QOL) in older adults. Findings from these studies indicate that the relationship between PA and QOL is indirect and likely mediated by variables such as physical self-esteem, exercise self-efficacy, and affect. As PA varies greatly by age, the purpose of the current study is to extend this area of research to young adults and explore the complex relationship between PA and QOL in this target population. METHODS: Data were collected via anonymous questionnaire from N = 590 undergraduate students...
March 2014: Quality of Life Research
Christian Seiler, Rebecca Engler, Lea Berner, Michael Stoller, Pascal Meier, Hélène Steck, Tobias Traupe
OBJECTIVE: To expand the limited information on the prognostic impact of quantitatively obtained collateral function in patients with coronary artery disease (CAD) and to estimate causality of such a relation. DESIGN: Prospective cohort study with long-term observation of clinical outcome. SETTING: University Hospital. PATIENTS: One thousand one hundred and eighty-one patients with chronic stable CAD undergoing 1771 quantitative, coronary pressure-derived collateral flow index measurements, as obtained during a 1-min coronary balloon occlusion (CFI is the ratio between mean distal coronary occlusive pressure and mean aortic pressure both subtracted by central venous pressure)...
October 2013: Heart: Official Journal of the British Cardiac Society
Carol A Wong, Lisa M Giallonardo
AIM: Our purpose was to test a model examining relationships among authentic leadership, nurses' trust in their manager, areas of work life and nurse-assessed adverse patient outcomes. BACKGROUND: Although several work environment factors have been cited as critical to patient outcomes, studies linking nursing leadership styles with patient outcomes are limited suggesting the need for additional research to investigate the mechanisms by which leadership may influence patient outcomes...
July 2013: Journal of Nursing Management
Ercole Vellone, Barbara Riegel, Antonello Cocchieri, Claudio Barbaranelli, Fabio D'Agostino, Giovanni Antonetti, Dale Glaser, Rosaria Alvaro
The Self-Care of Heart Failure Index Version 6.2 (SCHFI v.6.2) is widely used, but its psychometric profile is still questioned. In a sample of 659 heart failure patients from Italy, we performed confirmatory factor analysis (CFA) to test the original construct of the SCHFI v.6.2 scales (Self-Care Maintenance, Self-Care Management, and Self-Care Confidence), with limited success. We then used exploratory factor analysis to determine the presence of separate scale dimensions, followed by CFA in a separate sub-sample...
October 2013: Research in Nursing & Health
Bianca L Segatto, Catherine M Sabiston, William J Harvey, Gordon A Bloom
PURPOSE: To examine relationships among transplant-specific psychological growth and distress, motivational regulations and health-enhancing physical activity (HEPA) among transplant recipients. METHODS: Participants (N = 138; Mage = 48 years; 58% male), who were primarily heart, liver, lung, and kidney transplant recipients, completed scientifically-supported questionnaires. The associations among transplant-specific emotional health, motivation, and HEPA were examined in a path model...
2013: Disability and Rehabilitation
József Sóki, Zsuzsa Eitel, Gabriella Terhes, Elisabeth Nagy, Edit Urbán
We detected four cfiA-bft1 doubly positive Bacteroides fragilis strains out of 486 B. fragilis isolates analyzed for antibiotic susceptibilities and antibiotic resistance genes from a recent pan-European survey. The prevalence of the enterotoxin bft genes was roughly equal among cfiA-negative and -positive B. fragilis strains. We also demonstrated that the cfiA-bft doubly positive strains had the most common B. fragilis genomic pattern (I.1.). Thus we concluded that the bft-carrying CTn86 conjugative transposons are mobile accounting for this unexpected simultaneous occurrence of the cfiA and bft genes...
October 2013: Anaerobe
Natalie Taylor, Rebecca Lawton, Mark Conner
BACKGROUND: Physical activity interventions are more likely to be effective if they target causal determinants of behaviour change. Targeting requires accurate identification of specific theoretical determinants of physical activity. Two studies were undertaken to develop and validate the Determinants of Physical Activity Questionnaire. METHODS: In Study 1, 832 male and female university staff and students were recruited from 49 universities across the UK and completed the 66-item measure, which is based on the Theoretical Domains Framework...
2013: International Journal of Behavioral Nutrition and Physical Activity
Marcia Russell, Pamela K Cupp, Rachel K Jewkes, Anik Gevers, Catherine Mathews, Chantel LeFleur-Bellerose, Jeon Small
This study aimed to describe potentially preventable factors in intimate partner violence (IPV) perpetration and victimization among South African 8th grade students. Data were collected during a pilot evaluation of a classroom 8th grade curriculum on gender-based violence prevention in nine public schools in Cape Town through self-completed interviews with 549 8th grade students, 238 boys and 311 girls. Structural equation models (SEM) predicting IPV were constructed with variables a priori hypothesized to be associated...
June 2014: Prevention Science: the Official Journal of the Society for Prevention Research
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