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https://www.readbyqxmd.com/read/29277562/evaluating-the-expression-level-of-co-stimulatory-molecules-cd-80-and-cd-86-in-different-types-of-colon-polyps
#1
N Peyravian, E Gharib, A Moradi, M Mobahat, P Tarban, P Azimzadeh, E Nazemalhosseini-Mojarad, H Asadzadeh Aghdaei
PURPOSE OF THE STUDY: Co-stimulatory molecules CD80 and CD86 are the members of B7 family, which stimulate the T lymphocytes in response to the malignant colon polyps. However, the expression of these molecules is depressed in cancers. In the present study, the transcription levels of CD80 and CD86 genes in the colon polyps (Precancerous lesions) and its association with the clinical features were examined. PATIENTS AND METHODS: Forty-nine biopsies samples from patients with the colorectal polyps and 10 healthy subjects were collected by the colonoscopy...
December 22, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29250584/endoscopic-full-thickness-resection-for-t1-early-rectal-cancer-a-case-series-and-video-report
#2
Paola Soriani, Gian Eugenio Tontini, Helmut Neumann, Germana de Nucci, Domenico De Toma, Barbara Bruni, Sara Vavassori, Luca Pastorelli, Maurizio Vecchi, Pavlos Lagoussis
Background and study aims:  Endoscopic treatment of malignant colorectal polyps is often challenging, especially for early rectal cancer (ERC) localized close to the dentate line. Conversely, the surgical approach may result in temporary or definitive stoma and in frequent post-surgical complications. The Full-Thickness Resection Device (FTRD ® ) System (Ovesco Endoscopy, Tübingen, Germany) is a novel system that, besides having other indications, appears to be promising for wall-thickness excision of intestinal T1 carcinoma following incomplete endoscopic resection...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29239347/chronic-constipation
#3
REVIEW
Michael Camilleri, Alexander C Ford, Gary M Mawe, Phil G Dinning, Satish S Rao, William D Chey, Magnus Simrén, Anthony Lembo, Tonia M Young-Fadok, Lin Chang
Chronic constipation is a prevalent condition that severely impacts the quality of life of those affected. Several types of primary chronic constipation, which show substantial overlap, have been described, including normal-transit constipation, rectal evacuation disorders and slow-transit constipation. Diagnosis of primary chronic constipation involves a multistep process initiated by the exclusion of 'alarm' features (for example, unintentional weight loss or rectal bleeding) that might indicate organic diseases (such as polyps or tumours) and a therapeutic trial with first-line treatments such as dietary changes, lifestyle modifications and over-the-counter laxatives...
December 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29173260/transanal-minimally-invasive-surgery-for-benign-large-rectal-polyps-and-early-malignant-rectal-cancers-experience-and-outcomes-from-the-first-canadian-centre-to-adopt-the-technique
#4
Antonio Caycedo-Marulanda, Henry Y Jiang, Erica L Kohtakangas
BACKGROUND: Transanal minimally invasive surgery (TAMIS) has emerged as a relatively new technique in treating early cancer and benign lesion of the rectum. The technique is likely to be widely adopted, surpassing other comparable techniques owing to its simple setup and cost-effectiveness. We assessed the outcomes of TAMIS at our centre. METHODS: We retrospectively reviewed prospectively collected data on 50 patients who underwent TAMIS for benign, malignant T1 or T2 cancers that were unfit for radical surgery over a 4-year period...
December 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29168640/underwater-hybrid-endoscopic-submucosal-dissection-in-a-rectal-polyp-a-case-report-of-a-new-application-of-underwater-endoscopy
#5
Joaquín Rodríguez Sánchez, Margarita Úbeda Muñoz, Eva de la Santa Belda, Pilar Olivencia Palomar, José Olmedo Camacho
BACKGROUND: Hybrid endoscopic submucosal dissection (ESD) has been described as an alternative to traditional ESD. This technique is less time consuming, but the en bloc resection rate is lower than in ESD. Similar to endoscopic mucosal resection, the underwater technique could improve preliminary disadvantages of hybrid ESD. CASE REPORT: We attempted a mixture resection technique of Hybrid ESD with underwater endoscopic mucosal resection (EMR). Using this approach, an underwater hybrid ESD was successfully performed without adverse events on a 71 year old woman with a 20 mm adenoma...
November 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29122600/width-and-depth-of-resection-for-small-colorectal-polyps-hot-versus-cold-snare-polypectomy
#6
Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Akihiro Sugita, Misa Yamauchi, Mitsuhiko Moriyama
BACKGROUND AND AIMS: Curability is associated with resection width and depth in polypectomy. We evaluated the resection width and depth achieved with hot snare polypectomy (HSP) and cold snare polypectomy (CSP) for small colorectal polyps. METHODS: In this single-center, prospective, randomized controlled study, patients with rectal or rectosigmoid polyps ≤10 mm in diameter were treated with HSP or CSP. Resection width was evaluated as mucosal defect size, measured immediately postprocedure and 1 day later...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29076685/causes-of-lower-gastrointestinal-bleeding-on-colonoscopy
#7
Attique-Ur-Rehman Jehangiri, Rahid Gul, Rania Hadayat, Adil Naseer Khan, Zabiullah, Liaqat Khursheed
BACKGROUND: Bleeding from anus is usually referred as rectal bleeding but actually rectal bleeding is defined as bleeding from lower colon or rectum, which means bleeding from a place distal to ligament of Treitz. This study was conducted to determine the frequency of different causes of rectal bleeding in patients at Ayub Teaching Hospital, Abbottabad. METHODS: One hundred and seventy-five patients with evidence of rectal bleed, without gender discrimination were selected by non-probability convenient sampling from the out-patient department and general medical wards...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29030001/the-occurrence-and-characteristics-of-endoscopically-unexpected-malignant-degeneration-in-large-rectal-adenomas
#8
Maxime E S Bronzwaer, Gijsbert D Musters, Renée M Barendse, Lianne Koens, Eelco J R de Graaf, Pascal G Doornebosch, Mathijs P Schwartz, Esther C J Consten, Erik J Schoon, Ignace H J T de Hingh, Pieter J Tanis, Evelien Dekker, Paul Fockens
INTRODUCTION: Large non-pedunculated rectal polyps are most commonly resected by endoscopic mucosal resection (EMR) or transanal endoscopic microsurgery (TEM). Despite preprocedural diagnostics, unexpected rectal cancer is incidentally encountered within the resected specimen. This study aimed to compare the diagnostic assessment and procedural characteristics of lesions with and without unexpected submucosal invasion. METHODS: A post-hoc analysis of a multicenter randomized trial (TREND study) was performed, in which patients with a non-pedunculated rectal polyp of ≥3 cm without endoscopic suspicion of invasive growth were randomized between EMR and TEM...
October 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28976027/underwater-endoscopic-mucosal-resection-of-an-intramucosal-carcinoma-located-from-the-lower-rectum-to-the-anal-canal
#9
LETTER
Kenta Hamada, Noriya Uedo, Hitoshi Tanishita
No abstract text is available yet for this article.
October 4, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28924587/colorectal-endoscopic-submucosal-dissection-predictors-and-neoplasm-related-gradients-of-difficulty
#10
Federico Iacopini, Yutaka Saito, Antonino Bella, Takuji Gotoda, Patrizia Rigato, Walter Elisei, Fabrizio Montagnese, Giampaolo Iacopini, Guido Costamagna
BACKGROUND AND STUDY AIM:  The role of colorectal endoscopic submucosal dissection (ESD) is standardized in Japan and East Asia, but technical difficulties hinder its diffusion. The aim was to identify predictors of difficulty for each neoplasm type. METHODS:  A competent operator performed all procedures. ESD difficulty was defined as: en bloc with a slow speed (< 0.07 cm (2) /min; 30 × 30 mm neoplasm in > 90 min), conversion to endoscopic mucosal resection, or resection abandonment...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28905101/transanal-minimally-invasive-surgery-for-rectal-polyps-and-selected-malignant-tumors-caution-concerning-intermediate-term-functional-results
#11
S H E M Clermonts, Y T van Loon, A H W Schiphorst, D K Wasowicz, D D E Zimmerman
PURPOSE: Transanal minimally invasive surgery (TAMIS) is gaining worldwide popularity as an alternative for the transanal endoscopic microsurgery (TEMS) method for the local excision of rectal polyps and selected neoplasms. Data on patient reported outcomes regarding short-term follow-up are scarce; data on functional outcomes for long-term follow-up is non-existent. METHODS: We used the fecal incontinence severity index (FISI) to prospectively assess the fecal continence on the intermediate-term follow-up after TAMIS...
December 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28836241/-standardized-development-of-transanal-endoscopic-microsurgery
#12
Guole Lin
Transanal endoscopic microsurgery (TEM) is currently the only one-port system in endoscopic surgery, which a direct endoluminal approach can lead to the target organ through a natural opening of human body. TEM has been applied in colorectal surgery for over 3 decades. Compared with radical surgery, TEM has the advantages, such as quicker recovery, shorter hospital stay and fewer complications. One perfect TEM surgical system, which mainly consists of three parts, namely peculiar rectoscope for surgery, special surgical instruments and imaging system, is the foundation of standardized development of TEM...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28753220/a-novel-method-for-rapid-and-quantitative-mechanical-assessment-of-soft-tissue-for-diagnostic-purposes-a-computational-study
#13
Javier Palacio-Torralba, Daniel W Good, Grant D Stewart, S Alan McNeill, Robert L Reuben, Yuhang Chen
Biological tissues often experience drastic changes in their microstructure due to their pathophysiological conditions. Such microstructural changes could result in variations in mechanical properties, which can be used in diagnosing or monitoring a wide range of diseases, most notably cancer. This paves the avenue for non-invasive diagnosis by instrumented palpation although challenges remain in quantitatively assessing the amount of diseased tissue by means of mechanical characterization. This paper presents a framework for tissue diagnosis using a quantitative and efficient estimation of the fractions of cancerous and non-cancerous tissue without a priori knowledge of tissue microstructure...
July 28, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28734990/cardiac-ischemia-after-epinephrine-injection-during-emr-for-a%C3%A2-large-rectal-polyp
#14
Shivkumar Budihal, Krish Ragunath
No abstract text is available yet for this article.
July 20, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28713061/the-extent-of-unnecessary-surgery-for-benign-rectal-polyps-in-the-netherlands
#15
L Laurien J van Nimwegen, L Leon M G Moons, J Joost M J Geesing, L Rene Arensman, M M Miangela Laclé, I Ivo A M J Broeders, P Peter P Viergever, J John N Groen, K Koen Kessels, M Thijs P Schwartz
BACKGROUND AND AIMS: Minimally invasive techniques are available to safely and efficaciously remove even the largest rectal polyps. This study aimed to investigate the magnitude of cases still referred for radical rectal surgery, the reasons for theses referrals, and to perform a re-evaluation of cases potentially suitable for endoscopic therapy. METHODS: A retrospective analysis of data from the Dutch Pathology Registry (PALGA) was performed using the records of patients who underwent major surgical treatment for a histologically proven benign rectal polyp between 2005 to 2014 in the Netherlands...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28694653/attenuated-adenomatous-polyposis-of-the-large-bowel-present-and-future
#16
EDITORIAL
Luca Roncucci, Monica Pedroni, Francesco Mariani
Attenuated adenomatous polyposis (AAP) is a poorly understood syndrome, that can be defined as the presence of 10-99 synchronous adenomas in the large bowel, and it is considered a phenotypic variant of familial adenomatous polyposis (FAP). This definition has the advantage of simplicity, but it may include sporadic multiple adenomas of the large bowel at an extreme, or FAP cases on the other side. AAP shows a milder phenotype than FAP, with an older age of onset of adenomas and cancer, and less frequent extracolonic manifestations...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28690771/multicenter-randomised-controlled-trial-comparing-the-high-definition-white-light-endoscopy-and-the-bright-narrow-band-imaging-for-colon-polyps
#17
Rajvinder Singh, Kuan Loong Cheong, Leonardo Zorron Cheng Tao Pu, Dileep Mangira, Doreen Siew Ching Koay, Carmen Kee, Siew Chien Ng, Rungsun Rerknimitr, Satimai Aniwan, Tiing-Leong Ang, Khean-Lee Goh, Shiaw Hooi Ho, James Yun-Wong Lau
AIM: To compare high definition white light endoscopy and bright narrow band imaging for colon polyps' detection rates. METHODS: Patients were randomised to high definition white light endoscopy (HD-WLE) or the bright narrow band imaging (bNBI) during withdrawal of the colonoscope. Polyps identified in either mode were characterised using bNBI with dual focus (bNBI-DF) according to the Sano's classification. The primary outcome was to compare adenoma detection rates (ADRs) between the two arms...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28684185/transabdominal-ultrasound-colonography-for-detection-of-colorectal-neoplasms-initial-clinical-experience
#18
Jin-Ya Liu, Li-Da Chen, Jian-Bo Xu, Hui Wu, Jin-Ning Ye, Xin-Hua Zhang, Xiao-Yan Xie, Wei Wang, Ming-De Lu
We investigated the feasibility of using ultrasound colonography (USC) to visualize the healthy colon and rectum and detect colorectal polyps. Eight healthy volunteers underwent USC after standard bowel preparation. The feasibility and image quality of USC in different segments were evaluated. Then, USC was conducted on eight patients with known colonic neoplasms using colonoscopy as the reference standard. For volunteers, USC examinations were successfully performed on four (50.0%) ascending, three (37.5%) transverse and eight (100%) descending colons, as well as all sigmoid colons and rectums...
July 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28666493/sporadic-case-of-peutz-jeghers-polyp-in-a-14-year-boy
#19
Naheed Sultan, Rabbiya Ali
Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis of the gastrointestinal tract, with pigmentation around lips, the buccal mucosa, and anal area. Patients have a strong family history. Patients of PJS present with abdominal pain, blood in stools, and occasionally melena because of polyps, along with classical mucocutaneous pigmentation. Very rarely a sporadic case of Peutz-Jeghers syndrome occurs in early childhood and adolescent. The case of a 14-year boy is reported, who presented with intussussception and bleeding per rectum due to jejunal polyp and a rectal polyp...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28647042/transanal-endoscopic-microsurgery-for-the-treatment-of-uncommon-rectal-lesions
#20
Manuel Ferrer-Márquez, Francisco Rubio-Gil, Sofía Ortega-Ruiz, Isabel Blesa-Sierra, Antonio Álvarez-García, Jaime Jorge-Cerrudo, Elisabet Vidaña-Márquez, Ricardo Belda-Lozano, Ángel Reina-Duarte
INTRODUCTION: Transanal endoscopic microsurgery (TEM) was developed as a less aggressive alternative treatment for rectal lesions (mainly adenomas and adenocarcinomas). However, its use for other rectal lesions has become more frequent, trying to reduce the morbidity associated with more invasive techniques. The aim of this study is to describe our experience in the use of TEM in other rectal lesions. METHODS: Retrospective and descriptive study including patients operated with TEM (from June 2008 to December 2016) for the treatment of rectal lesions different from adenomas or adenocarcinomas...
June 2017: Cirugía Española
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