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https://www.readbyqxmd.com/read/29684854/the-role-of-her2-nrf2-axis-in-induction-of-oxaliplatin-resistance-in-colon-cancer-cells
#1
Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Kobra Velaie, Mohammad Reza Sadeghi, Nasser Samadi
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in promoting chemoresistance by regulation of antioxidants and detoxification enzymes. Her2 is a member of tyrosine kinase receptor family with a key function in resistance of cancer cells to chemotherapeutics. The aim of this study was to investigate the possible cross talk between Nrf2 and Her2 mediated signaling pathways in development of oxaliplatin resistance in colon cancer cells. We first generated oxaliplatin-resistant LS174T and SW480 colon cancer cells with different Her2 expression levels by employing IC50 concentrations followed by a resting period...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684692/acute-toxic-responses-of-embryo-larval-zebrafish-to-zinc-pyrithione-zpt-reveal-embryological-and-developmental-toxicity
#2
Ye Zhao, Yuyang Liu, Jing Sun, Hongtao Sha, Yu Yang, Qian Ye, Qi Yang, Baoqi Huang, Yadong Yu, He Huang
Zinc pyrithione (ZPT) is widely used in industrial and human daily life, due to its broad antimicrobial spectrum activity. Persistent accumulation of ZTP in the aquatic environment and bioaccumulation in the living organisms attracts more and more attention. However, only very limited information is available so far for the evaluation of systematic toxicity effects of ZPT on multiple organs development. This study intends to deepen our knowledge about the potential toxicity elicited by ZPT by assessing its acute effects on zebrafish (Danio rerio) through morphological, histological and molecular investigations...
April 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684678/hydrogen-bonds-autonomously-powered-gelatin-methacrylate-hydrogels-with-super-elasticity-self-heal-and-underwater-self-adhesion-for-sutureless-skin-and-stomach-surgery-and-e-skin
#3
Bingcheng Liu, Ying Wang, Yong Miao, Xinyu Zhang, Zhexiang Fan, Gurankit Singh, Xingying Zhang, Kaige Xu, Bingyun Li, Zhiqi Hu, Malcolm Xing
Interface-interaction induced self-healing and self-adhesive are a gem-like attribute inspired by our Mother Nature. Biocompatible gelatin methacrylate (GelMA) hydrogels exhibit tunable mechanical properties which are favorable in biomedical applications. However, it is difficult to integrate high stiffness, super-elasticity, large deformability and self-healing property together. Here, we report a GelMA-based double-network (DN) hydrogel with above properties by utilizing tannic acid (TA) as a multi-functional H-bond provider...
April 15, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684677/human-stem-cell-based-corneal-tissue-mimicking-structures-using-laser-assisted-3d-bioprinting-and-functional-bioinks
#4
Anni Sorkio, Lothar Koch, Laura Koivusalo, Andrea Deiwick, Susanna Miettinen, Boris Chichkov, Heli Skottman
There is a high demand for developing methods to produce more native-like 3D corneal structures. In the present study, we produced 3D cornea-mimicking tissues using human stem cells and laser-assisted bioprinting (LaBP). Human embryonic stem cell derived limbal epithelial stem cells (hESC-LESC) were used as a cell source for printing epithelium-mimicking structures, whereas human adipose tissue derived stem cells (hASCs) were used for constructing layered stroma-mimicking structures. The development and optimization of functional bioinks was a crucial step towards successful bioprinting of 3D corneal structures...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684626/multi-scale-structural-design-and-biomechanics-of-the-pistol-shrimp-snapper-claw
#5
Shahrouz Amini, Maryam Tadayon, J Q Isaiah Chua, Ali Miserez
The Arthropoda, the largest phylum of the Animal Kingdom, have successfully evolved to survive various ecological constraints under a wide range of environmental conditions. Central to this survival are the structural designs developed in their exoskeletons and their raptorial appendages for protection and hunting. One such example, the pistol shrimp, is a shallow-water crustacean that is well-known for its aggressive hunting behavior, using its snapper claw to trigger the nucleation of cavitation bubbles that strike targets...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684625/nanomechanics-and-ultrastructure-of-the-internal-mammary-artery-adventitia-in-patients-with-low-and-high-pulse-wave-velocity
#6
Zhuo Chang, Paolo Paoletti, Steve D Barrett, Ya Hua Chim, Eva Caamaño-Gutiérrez, Maria Lyck Hansen, Hans Christian Beck, Lars Melholt Rasmussen, Riaz Akhtar
The collagen-rich adventitia is the outermost arterial layer and plays an important biomechanical and physiological role in normal vessel function. While there has been a lot of effort to understand the role of the medial layer on arterial biomechanics, the adventitia has received less attention. In this study, we hypothesized that different ultrastructural and nanomechanical properties would be exhibited in the adventitia of the internal mammary artery (IMA) in patients with a low degree of arterial stiffening as compared to those with a high degree of arterial stiffening...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684584/deletion-of-epithelial-cell-specific-cdc42-leads-to-enamel-hypermaturation-in-a-conditional-knockout-mouse-model
#7
Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang, Buling Wu, Lin Zhang
Recent evidence suggests that GTPases Rho family plays an important role in tooth development; however, the role of Cdc42 in tooth development remains unclear. We aimed to investigate the function of Cdc42 in tooth development and amelogenesis. We generated an epithelial cell-specific K5-Cdc42 knockout (KO) mouse to evaluate post-eruption dental phenotypes using a K5-Cre driver line. This model overcomes the previously reported perinatal lethality. Tooth phenotypes were analyzed by micro X-ray, micro-computed tomography (CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), wear rate, shear strength, and a microhardness test...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684556/comparative-morphology-of-the-thorax-musculature-of-adult-anisoptera-insecta-odonata-functional-aspects-of-the-flight-apparatus
#8
Fabian Bäumler, Stanislav N Gorb, Sebastian Büsse
Due to their unique flight mechanism including a direct flight musculature, Odonata show impressive flight skills. Several publications addressed the details of this flight apparatus like: sclerites, wings, musculature, and flight aerodynamics. However, 3D-analysis of the thorax musculature of adult dragonflies was not studied before and this paper allows for a detailed insight. We therefore, focused on the thorax musculature of adult Anisoptera using micro-computed tomography. Herewith, we present a comparative morphological approach to identify differences within Anisoptera: Aeshnidae, Corduliidae, Gomphidae, and Libellulidae...
April 20, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29684498/multi-modal-characterization-of-vasculature-and-nanoparticle-accumulation-in-five-tumor-xenograft-models
#9
Einar Sulheim, Jana Kim, Annemieke van Wamel, Eugene Kim, Sofie Snipstad, Igor Vidic, Ingeborg Hovde Grimstad, Marius Widerøe, Sverre H Torp, Steinar Lundgren, David J Waxman, Catharina de Lange Davies
Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. A better understanding of how tumor heterogeneity affects nanoparticle accumulation could help elucidate this discrepancy and help in patient selection for nanomedicine therapy. Here we studied five human tumor models with varying morphology and evaluated the accumulation of 100 nm polystyrene nanoparticles...
April 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29684385/upregulation-of-ca-v-3-2-t-type-calcium-channels-in-adjacent-intact-l4-dorsal-root-ganglion-neurons-in-neuropathic-pain-rats-with-l5-spinal-nerve-ligation
#10
Qing-Ying Liu, Wen Chen, Shuang Cui, Fei-Fei Liao, Ming Yi, Feng-Yu Liu, You Wan
Besides the injured peripheral dorsal root ganglion (DRG) neurons, the adjacent intact DRG neurons also have important roles in neuropathic pain. Ion channels including Cav 3.2 T-type calcium channel in the DRG neurons are important in the development of neuropathic pain. In the present study, we aimed to examine the expression of Cav 3.2 T-type calcium channels in the intact DRG neurons in neuropathic pain. A neuropathic pain model of rat with lumbar 5 (L5) spinal nerve ligation (SNL) was established, in which the L4 DRG was separated from the axotomized L5 DRG, and the molecular, morphological and electrophysiological changes of Cav 3...
April 20, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29684212/cadmium-exposure-of-female-mice-impairs-the-meiotic-maturation-of-oocytes-and-subsequent-embryonic-development
#11
Jia-Qiao Zhu, Yang Liu, Jiang-Hong Zhang, Yan-Fang Liu, Jiang-Qin Cao, Zhu-Tao Huang, Yan Yuan, Jian-Chun Bian, Zong-Ping Liu
Cadmium is one major pollutant that is highly toxic to animals and humans. The mechanism of cadmium toxicity on the female reproductive system, particularly oocyte maturation and fertility, remains to be clarified. In the present study, we used a mouse model to investigate the effects of cadmium in the drinking water on the meiotic maturation of oocytes and subsequent embryonic development, and the underlying mechanisms associated with the impairment of oocyte maturation such as mitochondrial distribution and histone modifications...
April 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29684089/alternative-ribosomal-proteins-are-required-for-growth-and-morphogenesis-of-mycobacterium-smegmatis-under-zinc-limiting-conditions
#12
Allexa Dow, Sladjana Prisic
Zinc is an essential micronutrient required for proper structure and function of many proteins. Bacteria regularly encounter zinc depletion and have evolved diverse mechanisms to continue growth when zinc is limited, including the expression of zinc-independent paralogs of zinc-binding proteins. Mycobacteria have a conserved operon encoding four zinc-independent alternative ribosomal proteins (AltRPs) that are expressed when zinc is depleted. It is unknown if mycobacterial AltRPs replace their primary paralogs in the ribosome and maintain protein synthesis under zinc-limited conditions, and if such replacements contribute to their physiology...
2018: PloS One
https://www.readbyqxmd.com/read/29683965/effect-of-dexmedetomidine-on-cerebral-vasospasm-and-associated-biomarkers-in-a-rat-subarachnoid-hemorrhage-model
#13
Young Song, Beom Jin Lim, Do-Hyeong Kim, Jin Woo Ju, Dong Woo Han
BACKGROUND: The α2 adrenergic agonist dexmedetomidine (DEX) has huge potential for protecting against cerebral vasospasm, a leading cause of death and disability after subarachnoid hemorrhage (SAH). Biomarker assays for SAH have recently emerged as tools for predicting vasospasm and outcomes. We investigated the effects of DEX on vasospasm and assessed relevant biomarkers in a rat SAH model. METHODS: Male Wistar rats were randomly assigned to sham (n=10), vehicle (n=10), SAH (n=10), or SAH+ DEX (n=10) groups...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29683871/sensorimotor-cortex-atrophy-in-patients-with-cervical-spondylotic-myelopathy
#14
Lanbo Wang, Bing Yu, Qun Li, Fei Qi, Qiyong Guo
Previous studies have shown compensatory adaptive changes in cerebral functions before surgery in patients with cervical spondylotic myelopathy (CSM), especially in the sensorimotor cortices. However, the structural changes in the sensorimotor cortices in patients with CSM remain poorly understood. The aim of this study was to assess the volumetric changes in the sensorimotor cortices using morphological MRI and to correlate these changes with clinical scales. We hypothesize that CSM causes atrophy in the sensorimotor cortices, which results in functional changes during CSM progression...
April 20, 2018: Neuroreport
https://www.readbyqxmd.com/read/29683670/structural-memory-effect-of-mg-al-and-zn-al-layered-double-hydroxides-in-the-presence-of-different-natural-humic-acids-process-and-mechanism
#15
Zhisheng Gao, Keiko Sasaki, Xinhong Qiu
The structural memory effect of layered double hydroxides (LDHs) is one of the important reasons for their extensive use in environmental remediation. In this study, humic acid (HA) was extracted from black soil and sediments and characterized to determine their structures. The regeneration mechanisms of calcinated LDHs (CLDHs) including different divalent metals (Mg-CLDH and Zn-CLDH) in deionized water and different HA solutions were carefully elucidated, and the reasons for the behavior differences in the two materials were explained...
April 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29683214/piezo1-functions-as-a-potential-oncogene-by-promoting-cell-proliferation-and-migration-in-gastric-carcinogenesis
#16
Jinglin Zhang, Yuhang Zhou, Tingting Huang, Feng Wu, Liping Liu, Johnny S H Kwan, Alfred S L Cheng, Jun Yu, Ka Fai To, Wei Kang
Gastric cancer (GC) is one of the most common malignancies in Asian areas. PIEZO1 has been implied to regulate epithelial homeostasis to play an important role in physiological processes. It is also related to tumor initiation and progression. However, the role of PIEZO1 has not yet been explored in GC. The expression of PIEZO1 in GC cell lines and primary samples was determined by qRT-PCR and Western blot. The clinical correlation of PIEZO1 in GC was evaluated by immunohistochemistry on tissue microarray. The oncogenic role of PIEZO1 was demonstrated in gastric tumorigenesis through a series of functional assays, including cell proliferation, cell invasion and flow cytometry analysis...
April 23, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29682745/calcium-binding-protein-and-some-neuropeptides-in-the-retina-of-octopus-vulgaris-a-morpho-histochemical-study
#17
Giovanna G Altobelli, Susan Van Noorden, Vincenzo Cimini
The existence of both calcium-binding proteins (CBPs) and neuropeptides in the retina and brain of various species of vertebrates and invertebrates is well documented. Octopus retina is particularly interesting because it represents a case of convergent evolution. The aim of this study was to characterize the distribution of two CBPs, calretinin and calbindin, in Octopus retina using morphology, in situ hybridization, immunocytochemistry and Western blot. Calretinin-like immunoreactivity was found in the photoreceptor cells, but unexpectedly also in the supporting cells...
April 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29682634/commentary-mir-132-212-modulates-seasonal-adaptation-and-dendritic-morphology-of-the-central-circadian-clock
#18
Lucia Mendoza-Viveros, Karl Obrietan, Hai-Ying M Cheng
Daily rhythms in behavior and physiology are coordinated by an endogenous clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. This central pacemaker also relays day length information to allow for seasonal adaptation, a process for which melatonin signaling is essential. How the SCN encodes day length is not fully understood. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression by directing target mRNAs for degradation or translational repression. The miR-132/212 cluster plays a key role in facilitating neuronal plasticity, and miR-132 has been shown previously to modulate resetting of the central clock...
2018: Journal of Neurology & Neuromedicine
https://www.readbyqxmd.com/read/29682163/increased-f-2-isoprostane-levels-in-semen-and-immunolocalization-of-the-8-iso-prostaglandin-f-2-%C3%AE-in-spermatozoa-from-infertile-patients-with-varicocele
#19
Giulia Collodel, Elena Moretti, Mariangela Longini, Nicola Antonio Pascarelli, Cinzia Signorini
Polyunsaturated fatty acid damages lead to alterations in sperm function. This study aimed to investigate the involvement of F2 -isoprostanes (F2 -IsoPs), oxidized lipid products from arachidonic acid, in sperm quality impairment. For this purpose, F2 -IsoP levels in semen and F2 -IsoP localization in spermatozoa were explored in infertile subjects affected by idiopathic infertility or varicocele, as well as in fertile men. As compared to fertile men, in the idiopathic infertility and varicocele groups, sperm concentration, motility, morphology, viability, and fertility index were significantly lower and the mean scores concerning sperm apoptosis, necrosis, and immaturity were significantly higher...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681871/handgrip-strength-as-a-darwinian-fitness-indicator-in-men
#20
REVIEW
Andrew C Gallup, Bernhard Fink
Handgrip strength (HGS) is a robust measure of overall muscular strength and function, and has long been predictive of a multitude of health factors and physical outcomes for both men and women. The fact that HGS represents such a ubiquitous measure of health and vitality may reflect the significance of this trait during human evolution. This trait is also highly sexually dimorphic due to influences of androgenic hormones and fat-free body mass, suggesting that it has been further elaborated through sexual selection...
2018: Frontiers in Psychology
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