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https://www.readbyqxmd.com/read/28425814/verbal-short-term-memory-and-language-impairments-in-cantonese-speakers-after-stroke
#1
Diana Wai-Lam Ho, Anthony Pak-Hin Kong, Nim-Ting Koon
PURPOSE: The study examined the relationship between verbal short-term memory (STM) and language impairment in Cantonese speakers after stroke. It is hypothesised that Cantonese speakers with left-hemisphere (LH) stroke would perform worse than those with right hemisphere (RH) stroke and normal controls. Specific linguistic factors of Cantonese might affect results in the tasks. METHOD: Fifteen participants with LH stroke, 10 with RH stroke and 25 healthy controls were tested with auditory-verbal immediate serial recall (ISR) tasks and auditory linguistic tasks...
February 21, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28415058/-a-case-of-arteriovenous-malformation-of-the-parotid-gland-associated-with-cowden-disease
#2
Kazuhiko Nishi, Satoshi Murai, Hisakazu Itami, Shinji Otsuka, Noboru Kusaka, Tsukasa Nishiura, Nobuhiko Kimura, Kotaro Ogihara
We report a rare case of arteriovenous malformation(AVM)of the parotid gland associated with Cowden disease successfully treated with preoperative embolization followed by surgical removal. A 39-year-old man with a history of Cowden disease presented with a pulsating and growing mass on his left lower jaw. Contrast-enhanced computed tomography(CT)and angiography revealed a high-flow AVM in the deep lobe of the left parotid gland. After intravascular embolization of the feeding arteries, surgery was performed using the NIM-response<sup>®</sup>3...
April 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28406448/development-of-a-new-high-sensitivity-2000-kg-mechanical-balance
#3
Jian Wang
Mass measurement of more than 500 kg on an electronic mass comparator has no better repeatability and linearity of measurement for meeting the calibration requirement of over class F1 weights from pharmacy and power generation plants. For this purpose, a new 2000 kg mechanical balance was developed by the National Institute of Metrology (NIM). The advantages of measurement of more than 500 kg on a new 2000 kg mechanical balance are introduced in the paper. In order to obtain high measurement uncertainty, four vertical forces of two sides of beam are measured and used as reference for adjustment of the beam position...
April 13, 2017: Sensors
https://www.readbyqxmd.com/read/28403207/biosecurity-messages-are-lost-in-translation-to-citizens-implications-for-devolving-management-to-citizens
#4
Marnie L Campbell, Dominic E P Bryant, Chad L Hewitt
The increasing focus of marine biosecurity agencies on transferring management responsibilities to citizens and industry begs the question whether devolved responsibility is a viable option for creating biosecurity outcomes. We examined recreational marine users' self-declared awareness of non-indigenous marine species (NIMS) at six locations in Tasmania, Australia and evaluated the accuracy of their awareness through recognition of four well-known NIMS with active awareness campaigns. We also investigated whether the activities of recreational marine users influence the accuracy of their NIMS recognition skills...
2017: PloS One
https://www.readbyqxmd.com/read/28401841/positive-valence-bias-and-parent-child-relationship-security-moderate-the-association-between-early-institutional-caregiving-and-internalizing-symptoms
#5
Michelle R Vantieghem, Laurel Gabard-Durnam, Bonnie Goff, Jessica Flannery, Kathryn L Humphreys, Eva H Telzer, Christina Caldera, Jennifer Y Louie, Mor Shapiro, Niall Bolger, Nim Tottenham
Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little is known about factors that can promote resilience following early institutional caregiving. In the current study, we investigated how adaptations in affective processing (i.e., positive valence bias) and family-level protective factors (i.e., secure parent-child relationships) moderate risk for internalizing symptoms in previously institutionalized (PI) youth...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28396694/synthesis-of-umbelliferone-derivatives-in-escherichia-coli-and-their-biological-activities
#6
Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim, Jae Kyung Sohng
BACKGROUND: Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human health. A uridine diphosphate glycosyltransferase YjiC from Bacillus licheniformis DSM 13, a cytochrome P450BM3 (CYP450 BM3) variant namely mutant 13 (M13) from Bacillus megaterium, and an O-methyltransferase from Streptomyces avermitilis (SaOMT2) were used for modifications of umbelliferone...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28391774/exploring-the-sensitivity-of-the-personality-assessment-inventory-symptom-validity-tests-in-detecting-response-bias-in-a-mixed-neuropsychological-outpatient-sample
#7
Owen J Gaasedelen, Douglas M Whiteside, Michael Basso
OBJECTIVE: Few studies have evaluated the symptom validity tests (SVTs) within the Personality Assessment Inventory (PAI) in a neuropsychological assessment context. Accordingly, the present study explored the accuracy of PAI SVTs in identifying exaggerated cognitive dysfunction in a mixed sample of outpatients referred for neuropsychological assessment. METHOD: Participants who failed two or more Performance Validity Tests (PVTs) were classified as having exaggerated cognitive dysfunction (n = 49)...
April 10, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28387326/demonstration-of-a-three-dimensional-negative-index-medium-operated-at-multiple-angle-incidences-by-monolithic-metallic-hemispherical-shells
#8
Ting-Tso Yeh, Tsung-Yu Huang, Takuo Tanaka, Ta-Jen Yen
We design and construct a three-dimensional (3D) negative index medium (NIM) composed of gold hemispherical shells to supplant an integration of a split-ring resonator and a discrete plasmonic wire for both negative permeability and permittivity at THz gap. With the proposed highly symmetric gold hemispherical shells, the negative index is preserved at multiple incident angles ranging from 0° to 85° for both TE and TM waves, which is further evidenced by negative phase flows in animated field distributions and outweighs conventional fishnet structures with operating frequency shifts when varying incident angles...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386383/genome-wide-hepatic-dna-methylation-changes-in-high-fat-diet-induced-obese-mice
#9
AhRam Yoon, Stephanie A Tammen, Soyoung Park, Sung Nim Han, Sang-Woon Choi
BACKGROUND/OBJECTIVES: A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk of these diseases. It is known that health effects of diet are partially conveyed through epigenetic mechanism including DNA methylation. In this study, we investigated the genome-wide hepatic DNA methylation to identify the epigenetic effects of HFD-induced obesity. MATERIALS AND METHODS: Seven-week-old male C57BL/6 mice were fed control diet (CD), calorie-restricted control diet (CRCD), or HFD for 16 weeks (after one week of acclimation to the control diet)...
April 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28385591/optimal-control-problems-of-mosquito-borne-disease-subject-to-changes-in-feeding-behavior-of-aedes-mosquitoes
#10
M A Masud, Byul Nim Kim, Yongkuk Kim
Dengue viruses (DENV) are transmitted to humans by the bite of Aedes mosquitoes. It is known that dengue virus infection in Aedes aegypti female mosquitoes makes a change in the feeding behavior of the infected mosquitoes. In this study, using the forces of infection, we incorporated the effect of changes in the feeding behavior of mosquitoes into the standard vector-borne SIR-SI model. It has been proved that both a single-strain model and a two-strain model exhibit forward bifurcations. Moreover, optimal implementations of control with specific prevention measures for dengue transmission are analyzed...
April 3, 2017: Bio Systems
https://www.readbyqxmd.com/read/28375716/does-the-convergent-validity-of-the-pai-antisocial-features-scale-depend-on-offender-response-style
#11
Brett O Gardner, Marcus T Boccaccini
Researchers have recently questioned the utility of the response style indicators included on many self-report measures of personality and psychopathology. We examined whether the size of convergent validity coefficients for Personality Assessment Inventory (PAI) Antisocial Features (ANT) scores depends on PAI validity scale scores. Using PAI and Psychopathy Checklist-Revised (PCL-R) scores from 477 offenders evaluated for civil commitment as sexually violent predators, we found that PAI Positive Impression (PIM), Negative Impression (NIM), Malingering Index (MAL), Defensiveness Index (DEF), and Infrequency (INF) scores moderated the association between ANT and PCL-R scores...
April 4, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28361034/combinatorial-ranking-of-gene-sets-to-predict-disease-relapse-the-retinoic-acid-pathway-in-early-prostate-cancer
#12
Hieu T Nim, Milena B Furtado, Mirana Ramialison, Sarah E Boyd
BACKGROUND: Quantitative high-throughput data deposited in consortia such as International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) present opportunities and challenges for computational analyses. METHODS: We present a computational strategy to systematically rank and investigate a large number (2(10)-2(20)) of clinically testable gene sets, using combinatorial gene subset generation and disease-free survival (DFS) analyses. This approach integrates protein-protein interaction networks, gene expression, DNA methylation, and copy number data, in association with DFS profiles from patient clinical records...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28352650/point-mutations-in-murine-nkx2-5-phenocopy-human-congenital-heart-disease-and-induce-pathogenic-wnt-signaling
#13
Milena B Furtado, Julia C Wilmanns, Anjana Chandran, Joelle Perera, Olivia Hon, Christine Biben, Taylor J Willow, Hieu T Nim, Gurpreet Kaur, Stephanie Simonds, Qizhu Wu, David Willians, Ekaterina Salimova, Nicolas Plachta, James M Denegre, Stephen A Murray, Diane Fatkin, Michael Cowley, James T Pearson, David Kaye, Mirana Ramialison, Richard P Harvey, Nadia A Rosenthal, Mauro W Costa
Mutations in the Nkx2-5 gene are a main cause of congenital heart disease. Several studies have addressed the phenotypic consequences of disrupting the Nkx2-5 gene locus, although animal models to date failed to recapitulate the full spectrum of the human disease. Here, we describe a new Nkx2-5 point mutation murine model, akin to its human counterpart disease-generating mutation. Our model fully reproduces the morphological and physiological clinical presentations of the disease and reveals an understudied aspect of Nkx2-5-driven pathology, a primary right ventricular dysfunction...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28332080/erratum-to-impaired-social-decision-making-mediates-the-association-between-adhd-and-social-problems
#14
Kathryn L Humphreys, Chardeé A Galán, Nim Tottenham, Steve S Lee
No abstract text is available yet for this article.
March 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28323403/discovery-of-potent-antiallodynic-agents-for-neuropathic-pain-targeting-p2x3-receptors
#15
Young-Hwan Jung, Yong-Chul Kim, Yeo Ok Kim, Hai Lin, Joong-Heui Cho, Jin-Hee Park, So-Deok Lee, Jinsu Bae, Koon Mook Kang, Yoon Gyoon Kim, Ae Nim Pae, Hyojin Ko, Chul-Seung Park, Myung Ha Yoon
Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system. In this study, 5-hydroxy pyridine derivatives were designed, synthesized, and evaluated for their in vitro biological activities by two-electrode voltage clamp assay at hP2X3 receptors. Among the novel hP2X3 receptor antagonists, intrathecal treatment of compound 29 showed parallel efficacy with pregabalin (calcium channel modulator) and higher efficacy than AF353 (P2X3 receptor antagonist) in the evaluation of its antiallodynic effects in spinal nerve ligation rats...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28285685/combination-treatment-with-erlotinib-and-ampelopsin-overcomes-erlotinib-resistance-in-nsclc-cells-via-the-nox2-ros-bim-pathway
#16
Seung-Woo Hong, Nam-Sook Park, Min Hye Noh, Ju A Shim, Byul-Nim Ahn, Yeong Seok Kim, Daejin Kim, Hyun-Kyung Lee, Dae Young Hur
OBJECTIVES: Erlotinib, a tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR), has been shown to have a dramatic effect in non-small cell lung cancer (NSCLC) patients with EGFR mutation. However, the presence of primary resistance or acquired resistance to EGFR-TKI is the most common reason for switching to other anti-cancer agents. Even though there are newer agents that have activity in the presence of the T790M mutation, identification of potential agents that could overcome resistance to EGFR-TKI is still needed for the treatment of NSCLC patients...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28263385/intraoperative-near-infrared-fluorescence-imaging-targeting-folate-receptors-identifies-lung-cancer-in-a-large-animal-model
#17
Jane J Keating, Jeffrey J Runge, Sunil Singhal, Sarah Nims, Ollin Venegas, Amy C Durham, Gary Swain, Shuming Nie, Philip S Low, David E Holt
BACKGROUND: Complete tumor resection is the most important predictor of patient survival with non-small cell lung cancer. Methods for intraoperative margin assessment after lung cancer excision are lacking. This study evaluated near-infrared (NIR) intraoperative imaging with a folate-targeted molecular contrast agent (OTL0038) for the localization of primary lung adenocarcinomas, lymph node sampling, and margin assessment. METHODS: Ten dogs with lung cancer underwent either video-assisted thoracoscopic surgery or open thoracotomy and tumor excision after an intravenous injection of OTL0038...
May 15, 2017: Cancer
https://www.readbyqxmd.com/read/28262862/determination-of-mercury-ii-in-water-at-sub-nanomolar-levels-by-laser-ablation-icpms-analysis-of-screen-printed-electrodes-used-as-a-portable-voltammetric-preconcentration-system
#18
Zuriñe Abrego, Nora Unceta, Alicia Sánchez, Alberto Gómez-Caballero, Luis Maria Berrio-Ochoa, M Aranzazu Goicolea, Ramón J Barrio
Environmental pollution by mercury in ambient water samples is a recognized problem worldwide. Sample preservation and transport to the laboratory lead to uncertain analytical results. This study outlines the development of a procedure for on-site electrodeposition of mercury from water samples on a screen-printed gold electrode (SPGE) using portable voltammetric techniques. Once in the laboratory, Hg is analyzed by laser ablation inductively coupled plasma-mass spectrometry (LA-ICPMS) in order to ensure that the required sensitivity and precision levels for environmental sample analysis are reached...
March 6, 2017: Analyst
https://www.readbyqxmd.com/read/28260678/copper-ii-interaction-with-the-human-prion-103-112-fragment-coordination-and-oxidation
#19
Gizella Csire, Lajos Nagy, Katalin Várnagy, Csilla Kállay
The prion protein (PrP) is a membrane-anchored cell surface glycoprotein containing 231 amino acids. It has been associated with a group of neurodegenerative disorders. Copper(II) interaction with the Human Prion 103-112 fragment and its mutants has been studied with various techniques. The studied human prion fragment contains both histidine and methionine residues, while methionine residues are systematically replaced or displaced in the studied mutants. pH-potentiometric, UV-Vis and circular dicroism spectroscopic techniques were applied to study the stoichiometry, stability and structure of the copper(II) complexes, while HPLC-MS and MS/MS were used for identifying the products of copper(II) catalyzed oxidation...
May 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28258613/assessment-of-the-binding-performance-of-histamine-imprinted-microspheres-by-frontal-analysis-capillary-electrophoresis
#20
Edwin F Romano, Joselito P Quirino, John L Holdsworth, Regina C So, Clovia I Holdsworth
Frontal analysis capillary electrophoresis was used to evaluate the binding performance of molecularly imprinted microspheres (MIM) towards its template histamine and analogues at pH 7, and compared to the high performance liquid chromatographic method. In both methods, batch binding was employed and the binding parameters were calculated from the measured concentration of unbound amine analytes and afforded comparable histamine equilibrium dissociation constants (Kd ∼ 0.4 mM). FACE was easily carried out at shorter binding equilibration time (i...
March 3, 2017: Electrophoresis
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