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https://www.readbyqxmd.com/read/28208911/meningitis-with-digital-gangrene-in-meningococcal-infection-an-atypical-presentation
#1
Jitendra Singh, Dandu Himanshu, Ranjit Kumar Nim, Anju Dinkar, Kamlesh Kumar Gupta
Meningococcal infection is an important public health concern. Neisseria meningitidis usually colonizes the nasopharynx of healthy adolescents and adults and remains as asymptomatic colonizer, while in rare cases it may present as invasive disease as either meningitis or septicemia or both. Most of the cases have typical presentation of rashes. We hereby present a case of a 40-year-old male who presented with meningococcal meningitis and peripheral digital gangrene but without development of typical rashes...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28202577/nimesulide-and-4-hydroxynimesulide-as-bile-acid-transporters-inhibitors-are-contributory-factors-for-drug-induced-cholestasis
#2
Lei Zhou, Xiaoyan Pang, Jingfang Jiang, Dafang Zhong, Xiaoyan Chen
Nimesulide (NIM) is a classic nonsteroidal anti-inflammatory drug. However, some patients treated with NIM suffered from cholestatic liver injury. For this reason, we investigated the potential mechanism underlying NIM-induced cholestasis by using in vivo and in vitro models. Oral administration of 100 mg/kg/day NIM to Wistar rats for 5 days increased the levels of plasma total bile acids, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase by 1.49-, 1.31-, 1.60-, and 1.29-fold, respectively...
February 15, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28194935/a-potential-pet-radiotracer-for-the-5-ht2c-receptor-synthesis-and-in-vivo-evaluation-of-4-3-18-f-fluorophenethoxy-pyrimidine
#3
Juhyeon Kim, Byung Seok Moon, Byung Chul Lee, Ho-Young Lee, Hak Joong Kim, Hyunah Choo, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT receptor widely distributed throughout the central nerve system. As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine and -aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety. Up to date, three kinds of 5-HT2C PET radiotracers such as [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2), [18F]fluorophenylcyclopropane (3) have been developed, but they may not be suitable for in vivo 5-HT2C imaging study due to their modest specific binding...
February 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28194664/phrenic-nerve-stimulation-during-neck-dissection-for-advanced-thyroid-cancer-involving-level-iv-is-it-worth-doing-it
#4
Carlos S Duque, Juan P Dueñas, Marcela Marulanda, Diana Pérez, Andres Londoňo, Soham Roy, Mai Al Khadem
During thyroidectomy and neck dissection surgery for advanced or recurrent metastatic thyroid cancer under intraoperative monitoring, we used the available technology to assess the feasibility of such an intervention to monitor those patients with phrenic nerves at risk. A retrospective review of patients operated on from January 2009 to December 2015 by a single surgeon (CSD) was conducted. Patients who had neck and mediastinal dissection, with or without total thyroidectomy, due to advanced or recurrent metastatic disease to the neck were selected...
February 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28194405/abundance-and-significance-of-neuroligin-1-and-neurexin-ii-in-the-enteric-nervous-system-of-embryonic-rats
#5
Dongming Wang, Jingnian Pan, Guoxin Song, Ni Gao, Yi Zheng, Qiangye Zhang, Aiwu Li
Aim. To investigate the abundance of neuroligin-1 and neurexin II in the enteric nervous system (ENS) of rats on different embryonic days and to explore their potential significance. Methods. The full-thickness colon specimens proximal to the ileocecal junction of rats on embryonic days 16, 18, and 20 and of newborns within 24 hours (E16, E18, E20, and Ep0) were studied, respectively. qRT-PCR was applied for detecting the expressions of neuroligin-1 and neurexin II on mRNA, and western blotting was employed for detecting their further expressions on the whole tissue...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28193145/constrained-cage-culture-improves-engineered-cartilage-functional-properties-by-enhancing-collagen-network-stability
#6
Robert J Nims, Alexander D Cigan, Krista M Durney, Brian K Jones, John D O'Neill, Wing-Sum A Law, Gordana Vunjak-Novakovic, Clark Tung-Hui Hung, Gerard A Ateshian
When cultured with sufficient nutrient supply, engineered cartilage synthesizes proteoglycans rapidly, producing an osmotic swelling pressure that destabilizes immature collagen and prevents the development of a robust collagen framework, a hallmark of native cartilage. We hypothesized that mechanically constraining the proteoglycan-induced tissue swelling would enhance construct functional properties through the development of a more stable collagen framework. To test this hypothesis, we developed a novel "cage" growth system to mechanically prevent tissue constructs from swelling while ensuring adequate nutrient supply to the growing construct...
February 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28184246/determination-of-glycoside-hydrolase-specificities-during-hydrolysis-of-plant-cell-walls-using-glycome-profiling
#7
Johnnie A Walker, Sivakumar Pattathil, Lai F Bergeman, Emily T Beebe, Kai Deng, Maryam Mirzai, Trent R Northen, Michael G Hahn, Brian G Fox
BACKGROUND: Glycoside hydrolases (GHs) are enzymes that hydrolyze polysaccharides into simple sugars. To better understand the specificity of enzyme hydrolysis within the complex matrix of polysaccharides found in the plant cell wall, we studied the reactions of individual enzymes using glycome profiling, where a comprehensive collection of cell wall glycan-directed monoclonal antibodies are used to detect polysaccharide epitopes remaining in the walls after enzyme treatment and quantitative nanostructure initiator mass spectrometry (oxime-NIMS) to determine soluble sugar products of their reactions...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28153762/chitosan-zein-nano-in-microparticles-capable-of-mediating-in-vivo-transgene-expression-following-oral-delivery
#8
Eric Farris, Deborah M Brown, Amanda E Ramer-Tait, Angela K Pannier
The oral route is an attractive delivery route for the administration of DNA-based therapeutics, specifically for applications in gene therapy and DNA vaccination. However, oral DNA delivery is complicated by the harsh and variable conditions encountered throughout gastrointestinal (GI) transit, leading to degradation of the delivery vector and DNA cargo, and subsequent inefficient delivery to target cells. In this work, we demonstrate the development and optimization of a hybrid-dual particulate delivery system consisting of two natural biomaterials, zein (ZN) and chitosan (CS), to mediate oral DNA delivery...
January 31, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28152427/discovery-of-1-3-benzyloxy-pyridin-2-yl-3-2-piperazin-1-yl-ethyl-urea-a-new-modulator-for-amyloid-beta-induced-mitochondrial-dysfunction
#9
Ahmed Elkamhawy, Jung-Eun Park, Ahmed H E Hassan, Hyunhwa Ra, Ae Nim Pae, Jiyoun Lee, Beoung-Geon Park, Bongjin Moon, Hyun-Mee Park, Eun Joo Roh
Herein, we report a new series of aliphatic substituted pyridyl-urea small molecules synthesized as potential modulators for amyloid beta (Aβ) induced mitochondrial dysfunction. Their blocking activities against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The inhibitory activity of sixteen compounds against Aβ-induced mPTP opening was superior or almost similar to that of the standard Cyclosporin A (CsA)...
December 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28150215/pulmonary-delivery-of-magnetically-targeted-nano-in-microparticles
#10
Amber A McBride, Dominique N Price, Pavan Muttil
This chapter details the intratracheal delivery of dry powder microparticles termed nano-in-microparticles (NIMs) for the purpose of in vivo targeted pulmonary drug delivery. The dry powder NIMs technology improves on previous inhaled chemotherapy platforms designed as liquid formulations. Dry powder microparticles were created through the process of spray drying; a protocol detailing the formulation of NIMs dry powder is included as a separate chapter in this book. Dry powder NIMs containing fluorescent nanoparticles and magnetically-responsive superparamagnetic iron oxide nanoparticles are intratracheally delivered (insufflated) in the presence of a magnetic field and targeted to the left lung of mice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28150197/preparation-and-characterization-of-magnetic-nano-in-microparticles-for-pulmonary-delivery
#11
Amber A McBride, Dominique N Price, Pavan Muttil
The purpose of this chapter is to detail the formulation and characterization of a magnetically-targeted drug delivery vehicle, termed nano-in-microparticles (NIMs), for pulmonary drug delivery. Currently, chemotherapeutics and antibiotics are delivered systemically and result in whole body side-effects. NIMs are formulated with superparamagnetic iron oxide nanoparticles, termed SPIONs, making these particles targetable to specific lung regions using a strong external magnet. Additionally, these particles can be formulated to contain any drug or therapeutic agent, such that a therapeutic dose can be delivered to a specific tissue location using the SPIONs-magnet interaction...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28135083/polarized-xanes-monitors-femtosecond-structural-evolution-of-photoexcited-vitamin-b12
#12
Nicholas A Miller, Aniruddha Deb, Roberto Alonso-Mori, Brady D Garabato, James M Glownia, Laura M Kiefer, Jake Koralek, Marcin Sikorski, Kenneth G Spears, Theodore E Wiley, Diling Zhu, Pawel M Kozlowski, Kevin J Kubarych, James E Penner-Hahn, Roseanne J Sension
Ultrafast, polarization-selective time-resolved X-ray absorption near-edge structure (XANES) was used to characterize the photochemistry of vitamin B12, cyanocobalamin (CNCbl), in solution. Cobalamins are important biological cofactors involved in methyl transfer, radical rearrangement, and light-activated gene regulation, while also holding promise as light-activated agents for spatiotemporal controlled delivery of therapeutics. We introduce polarized femtosecond XANES, combined with UV-visible spectroscopy, to reveal sequential structural evolution of CNCbl in the excited electronic state...
January 30, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28134814/ixeris-dentata-thunb-ex-thunb-nakai-extract-inhibits-proliferation-and-induces-apoptosis-in-breast-cancer-cells-through-akt-nf-%C3%AE%C2%BAb-pathways
#13
Seong-Ah Shin, Hae-Nim Lee, Gang-Sik Choo, Hyeong-Jin Kim, Jeong-Hwan Che, Ji-Youn Jung
Ixeris dentata (Thunb. Ex Thunb.) Nakai (ID) exhibits various physiological activities, and its related plant derived-products are expected to represent promising cancer therapeutic agents. However, the anticancer effects of ID extract on breast cancer cells classified as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are still unknown. In this study, we investigated the anti-cancer effects and analyzed the molecular mechanism of ID extract in T47D, MCF-7 (ER-, PR-positive, HER2-negative), SK-BR-3(ER-, PR-negative, HER2-positive), and MDA-MB-231 (Triple-negative) through in vitro studies...
January 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28125311/functional-outcomes-following-immediate-repair-of-penile-fracture-a-tertiary-referral-centre-experience-with-76-consecutive-patients
#14
Francesco De Luca, Giulio Garaffa, Marco Falcone, Amr Raheem, Evangelos Zacharakis, Majed Shabbir, Abdelkareem Aljubran, Asif Muneer, Fiona Holden, Claire Akers, Nim Christopher, David J Ralph
OBJECTIVE: The aim of this study was to report surgical and functional outcomes in patients who underwent immediate penile fracture repair following location of the tunical tear with ultrasonography. METHODS: Patients' clinical notes from September 2005 to October 2015 were reviewed. The inclusion criteria were the documented presence of an albugineal laceration at the preoperative ultrasonography and during surgical exploration. In total, 76 patients were enrolled in the study...
January 26, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28116547/14-3-3%C3%AE-depletion-drives-a-senescence-program-in-glioblastoma-cells-through-the-erk-skp2-p27-pathway
#15
Sung Bin Seo, Je-Jung Lee, Hye Hyeon Yun, Chang-Nim Im, Yong-Sam Kim, Jeong-Heon Ko, Jeong-Hwa Lee
The induction of senescence in cancer cells has recently been implicated as a mechanism of tumor regression in response to various modes of stress. 14-3-3 proteins are conserved scaffolding molecules that are involved in various cellular functions. Among the seven isoforms, 14-3-3β is specifically expressed in astrocytoma in correlation with the malignancy grade. We investigated the possible role of 14-3-3β in the regulation of senescence induction in A172 glioblastoma cells. The knockdown of 14-3-3β by specific small interfering RNA resulted in a significant change in cellular phenotypes and an increase in cells staining positive for senescence-associated β-galactosidase...
January 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28114683/physician-decision-making-and-clinical-outcomes-with-laboratory-polysomnography-or-limited-channel-sleep-studies-for-obstructive-sleep-apnea-a-randomized-trial
#16
Ching Li Chai-Coetzer, Nick A Antic, Garun S Hamilton, Nigel McArdle, Keith Wong, Brendon J Yee, Aeneas Yeo, Rajeev Ratnavadivel, Matthew T Naughton, Teanau Roebuck, Richard Woodman, R Doug McEvoy
Background: The clinical utility of limited-channel sleep studies (which are increasingly conducted at home) versus laboratory polysomnography (PSG) for diagnosing obstructive sleep apnea (OSA) is unclear. Objective: To compare patient outcomes after PSG versus limited-channel studies. Design: Multicenter, randomized, noninferiority study. (Australian New Zealand Clinical Trials Registry: ACTRN12611000926932). Setting: 7 academic sleep centers...
January 24, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28113021/fentanyl-sublingual-tablets-versus-subcutaneous-morphine-for-the-management-of-severe-cancer-pain-episodes-in-patients-receiving-opioid-treatment-a-double-blind-randomized-noninferiority-trial
#17
Ernesto Zecca, Cinzia Brunelli, Fabio Centurioni, Andrea Manzoni, Alessandra Pigni, Augusto Caraceni
Purpose Fentanyl sublingual tablets (FST) are a potentially useful alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain episodes. No direct comparison between FST and SCM is available. The aim of this study was to test noninferiority of FST versus SCM during the first 30 min postadministration. Methods Patients receiving stable opioid therapy and experiencing a severe pain episode were randomly assigned to either 100 µg FST or 5 mg SCM in a double-blind, double-dummy trial...
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28106996/evaluation-of-jatrophane-esters-from-euphorbia-spp-as-modulators-of-candida-albicans-multidrug-transporters
#18
Mélissa Esposito, Shweta Nim, Louis-Félix Nothias, Jean-François Gallard, Manpreet Kaur Rawal, Jean Costa, Fanny Roussi, Rajendra Prasad, Attilio Di Pietro, Julien Paolini, Marc Litaudon
Twenty-nine jatrophane esters (1-10, 12-30) and one lathyrane (11) diterpenoid ester isolated from Euphorbia species were evaluated for their capacity to inhibit drug-efflux activities of the primary ABC transporter CaCdr1p and the secondary MFS transporter CaMdr1p of Candida albicans, in yeast strains overexpressing the corresponding transporter. These diterpenoid esters were obtained from Euphorbia semiperfoliata (1-10), E. insularis (11), and E. dendroides (12-30) and included five new compounds, euphodendroidins P-T (26-30)...
January 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28101144/histopathological-findings-in-systemic-sclerosis-related-myopathy-fibrosis-and-microangiopathy-with-lack-of-cellular-inflammation
#19
Claudio Corallo, Maurizio Cutolo, Nila Volpi, Daniela Franci, Margherita Aglianò, Antonio Montella, Chiara Chirico, Stefano Gonnelli, Ranuccio Nuti, Nicola Giordano
OBJECTIVES: The objective of this study was to identify specific histopathological features of skeletal muscle involvement in systemic sclerosis (SSc) patients. METHODS: A total of 35 out of 112 SSc-patients (32%, including 81% female and 68% diffuse scleroderma) presenting clinical, biological and electromyographic (EMG) features of muscle weakness, were included. Patients underwent vastus lateralis biopsy, assessed for individual pathologic features including fibrosis [type I collagen (Coll-I), transforming growth factor β (TGF-β)], microangiopathy [cluster of differentiation 31 (CD31), pro-angiogenic vascular endothelial growth factor A (VEGF-A), anti-angiogenic VEGF-A165b], immune/ inflammatory response [CD4, CD8, CD20, human leucocyte antigens ABC (HLA-ABC)], and membranolytic attack complex (MAC)...
January 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28017534/direct-motor-evoked-potentials-and-cortical-mapping-using-the-nim%C3%A2-nerve-monitoring-system-a-technical-note
#20
Suparna Bharadwaj, Faizal Haji, Matthew Hebb, Jason Chui
Motor evoked potentials (MEPs) are commonly used to prevent neurological injury when operating in close proximity to the motor cortex or corticospinal pathway. We report a novel application of the NIM® nerve monitoring system (Medtronic@ NIM response 3.0) for intraoperative direct cortical (dc)-MEPs monitoring. A 69-year-old female patient presented with a 4month history of progressive left hemiparesis resulting from a large right sided posterior frontal meningioma that abutted and compressed the motor cortex...
December 22, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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