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https://www.readbyqxmd.com/read/29338553/comprehensive-clinicopathologic-and-updated-immunohistochemical-characterization-of-primary-ovarian-mucinous-carcinoma
#1
Dina Bassiouny, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Carlos Parra-Herran, Hak Fai Chiu, Magda Naeim, Nim Li, Mahmoud Khalifa, Sharon Nofech-Mozes
The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29330340/the-adiponectin-receptor-agonist-adiporon-ameliorates-diabetic-nephropathy-in-a-model-of-type-2-diabetes
#2
Yaeni Kim, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Hye Eun Yoon, Seok Joon Shin, Bum Soon Choi, Yong-Soo Kim, Yoon Sik Chang, Cheol Whee Park
Adiponectin exerts renoprotective effects against diabetic nephropathy (DN) by activating the AMP-activated protein kinase (AMPK)/peroxisome proliferative-activated receptor-α (PPARα) pathway through adiponectin receptors (AdipoRs). AdipoRon is an orally active synthetic adiponectin receptor agonist. We investigated the expression of AdipoRs and the associated intracellular pathways in 27 patients with type 2 diabetes and examined the effects of AdipoRon on DN development in male C57BLKS/J db/db mice, glomerular endothelial cells (GECs), and podocytes...
January 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29326403/resveratrol-an-nrf2-activator-ameliorates-aging-related-progressive-renal-injury
#3
Eun Nim Kim, Ji Hee Lim, Min Young Kim, Tae Hyun Ban, In-Ae Jang, Hye Eun Yoon, Cheol Whee Park, Yoon Sik Chang, Bum Soon Choi
BACKGROUND: Two important issues in the aging kidney are mitochondrial dysfunction and oxidative stress. An Nrf2 activator, resveratrol, is known to have various effects. Resveratrol may prevent inflammation and oxidative stress by activating Nrf2 and SIRT1 signaling. We examined whether resveratrol could potentially ameliorate the cellular condition, such as renal injury due to cellular oxidative stress and mitochondrial dysfunction caused by aging. METHODS: Male 18-month-old C57BL/6 mice were used...
January 11, 2018: Aging
https://www.readbyqxmd.com/read/29316216/transvaginal-evisceration-of-small-bowel
#4
James W T Toh, Taina Lee, Corinna Chiong, Grahame Ctercteko, Nim Pathma-Nathan, Toufic El Khoury, Danette Wright, Jennifer King
No abstract text is available yet for this article.
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29310210/a-new-and-simple-method-for-the-simultaneous-determination-of-amoxicillin-and-nimesulide-using-carbon-black-within-a-dihexadecylphosphate-film-as-electrochemical-sensor
#5
Patrícia B Deroco, Romeu C Rocha-Filho, Orlando Fatibello-Filho
The first electroanalytical method for the simultaneous determination of an important antibiotic (amoxicillin - AMX) and an anti-inflammatory drug (nimesulide -NIM), widely used in combination, is here proposed. In this method, a glassy carbon (GC) substrate modified with carbon black (CB) immobilized within a dihexadecylphosphate (DHP) film is used as electrochemical sensor (CB-DHP/GC). The electrochemical activity of this sensor was assessed (comparatively to that of GC) by electrochemical impedance spectroscopy, using the [Fe(CN)6]3-/4- redox couple, when two different active electron transfer regions were clearly characterized...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29288949/synthesis-and-evaluation-of-2-3-arylureido-pyridines-and-2-3-arylureido-pyrazines-as-potential-modulators-of-a%C3%AE-induced-mitochondrial-dysfunction-in-alzheimer-s-disease
#6
Ahmed Elkamhawy, Jung-Eun Park, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Beoung-Geon Park, Eun Joo Roh
A series of 2-(3-arylureido)pyridines and 2-(3-benzylureido)pyridines were synthesized and evaluated as potential modulators for amyloid beta (Aβ)-induced mitochondrial dysfunction in Alzheimer's disease (AD). The blocking activities of forty one small molecules against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The inhibitory activity of twenty five compounds against Aβ-induced mPTP opening was superior to that of the standard cyclosporin A (CsA)...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29281268/hydrogen-bonding-effects-in-five-coordinate-high-spin-imidazole-ligated-iron-ii-porphyrinates
#7
Chuanjiang Hu, Bruce C Noll, Charles E Schulz, W Robert Scheidt
The influence of hydrogen binding to the N-H group of coordinated imidazole in high-spin iron(II) porphyrinates has been studied. The preparation and characterization of new complexes based on [Fe(TPP)(2-MeHIm)] (TPP is the dianion of tetraphenylporphyrin) are reported. The hydrogen bond acceptors are ethanol, tetramethylene sulfoxide, and 2-methylimidazole. The last acceptor, 2-MeHIm, was found in a crystalline complex with two [Fe(TPP)(2-MeHIm)] sites, only one of which has the 2-methylimidazole hydrogen bond acceptor...
December 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29248297/facile-conversion-of-atp-binding-rna-aptamer-to-quencher-free-molecular-aptamer-beacon
#8
Yoojin Park, Duangrat Nim-Anussornkul, Tirayut Vilaivan, Takashi Morii, Byeang Hyean Kim
We have developed RNA-based quencher-free molecular aptamer beacons (RNA-based QF-MABs) for the detection of ATP, taking advantage of the conformational changes associated with ATP binding to the ATP-binding RNA aptamer. The RNA aptamer, with its well-defined structure, was readily converted to the fluorescence sensors by incorporating a fluorophore into the loop region of the hairpin structure. These RNA-based QF-MABs exhibited fluorescence signals in the presence of ATP relative to their low background signals in the absence of ATP...
December 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29227126/intentional-inattention-detecting-feigned-attention-deficit-hyperactivity-disorder-on-the-personality-assessment-inventory
#9
Shannon T Smith, Jennifer Cox, Elyse N Mowle, John F Edens
Given the increasing number of college students seeking Attention-Deficit/Hyperactivity Disorder (ADHD) diagnoses as well as the potential secondary gains associated with this disorder (e.g., access to stimulant medication, academic accommodations), the detection of malingered symptom presentations in this population is a major concern. The present study examined the ability of validity indicators on the widely used Personality Assessment Inventory (PAI; Morey, 1991) to distinguish between individuals experiencing genuine ADHD symptoms and individuals instructed to present with ADHD symptomatology for secondary gain...
December 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29220583/elevated-serum-vitamin-b12-levels-as-a-prognostic-factor-for-survival-time-in-metastatic-cancer-patients-a-retrospective-study
#10
Hye Kyung Oh, Jee Young Lee, Wan Kyu Eo, Seong Woo Yoon, Sung Nim Han
BACKGROUND: Serum vitamin B12 levels have been proposed as one of the survival prediction factors, although no survival analysis in metastatic cancer patients has been conducted yet. This study examined whether serum vitamin B12 levels could be a prognostic factor in metastatic cancer patients. METHODS: Data from a retrospective chart review were used to perform Kaplan-Meier and multivariate analyses of the Cox proportional hazards. Subgroup analysis was performed on patients without a liver lesion (hepatocellular carcinoma or liver metastasis)...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29215787/miniaturized-battery-free-optofluidic-systems-with-potential-for-wireless-pharmacology-and-optogenetics
#11
Kyung Nim Noh, Sung Il Park, Raza Qazi, Zhanan Zou, Aaron D Mickle, Jose G Grajales-Reyes, Kyung-In Jang, Robert W Gereau, Jianliang Xiao, John A Rogers, Jae-Woong Jeong
Combination of optogenetics and pharmacology represents a unique approach to dissect neural circuitry with high specificity and versatility. However, conventional tools available to perform these experiments, such as optical fibers and metal cannula, are limited due to their tethered operation and lack of biomechanical compatibility. To address these issues, a miniaturized, battery-free, soft optofluidic system that can provide wireless drug delivery and optical stimulation for spatiotemporal control of the targeted neural circuit in freely behaving animals is reported...
December 7, 2017: Small
https://www.readbyqxmd.com/read/29207645/nitidine-chloride-acts-as-an-apoptosis-inducer-in-human-oral-cancer-cells-and-a-nude-mouse-xenograft-model-via-inhibition-of-stat3
#12
Lee-Han Kim, Sachita Khadka, Ji-Ae Shin, Ji-Youn Jung, Mi-Heon Ryu, Hyun-Ju Yu, Hae Nim Lee, Boonsil Jang, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Joseph H Jeong, Seong Doo Hong, Nam-Pyo Cho, Sung-Dae Cho
Nitidine chloride (NC) is a natural alkaloid compound derived from the plant Zanthoxylum nitidum and is known for its therapeutic anticancer potential. In this study, we investigated the effects of NC on growth and signaling pathways in human oral cancer cell lines and a tumor xenograft model. The apoptotic effects and related molecular targets of NC on human oral cancer were investigated using trypan blue exclusion assay, DAPI staining, Live/Dead assay, Western blotting, Immunohistochemistry/Immunofluorescence and a nude mouse tumor xenograft...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207037/anti%C3%A2-inflammatory-effect-of-quercetin-and-galangin-in-lps%C3%A2-stimulated-raw264-7-macrophages-and-dncb%C3%A2-induced-atopic-dermatitis-animal-models
#13
Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Jeong Hwan Che, Byung Kwon Park, Ji Youn Jung
Flavonols are compounds that have been shown to possess potent anti‑inflammatory effects in cellular and animal models of inflammation. In the present study, the anti‑inflammatory effects and mechanisms of two natural flavonols, quercetin and galangin, in lipopolysaccharide (LPS)‑stimulated RAW264.7 macrophages were investigated. It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin‑6, and the nuclear translocation of nuclear factor‑κB (NF‑κB)...
November 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29203664/structural-insights-into-how-gtp-dependent-conformational-changes-in-a-metallochaperone-ureg-facilitate-urease-maturation
#14
Man Hon Yuen, Yu Hang Fong, Yap Shing Nim, Pak Ho Lau, Kam-Bo Wong
The ability of metallochaperones to allosterically regulate the binding/release of metal ions and to switch protein-binding partners along the metal delivery pathway is essential to the metallation of the metalloenzymes. Urease, catalyzing the hydrolysis of urea into ammonia and carbon dioxide, contains two nickel ions bound by a carbamylated lysine in its active site. Delivery of nickel ions for urease maturation is dependent on GTP hydrolysis and is assisted by four urease accessory proteins UreE, UreF, UreG, and UreH(UreD)...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29198609/synthesis-and-evaluation-of-biaryl-derivatives-for-structural-characterization-of-selective-monoamine-oxidase-b-inhibitors-toward-parkinson-s-disease-therapy
#15
Seul Ki Yeon, Ji Won Choi, Jong-Hyun Park, Ye Rim Lee, Hyeon Jeong Kim, Su Jeong Shin, Bo Ko Jang, Siwon Kim, Yong-Sun Bahn, Gyoonhee Han, Yong Sup Lee, Ae Nim Pae, Ki Duk Park
Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, 12c exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC50: 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor...
November 24, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29197028/best-practices-for-authenticating-cell-lines
#16
REVIEW
Raymond W Nims, Yvonne Reid
Experiments using cell cultures are only valid to the extent that the cell culture is a true model system for the biological system being investigated. To assure that a cell line is and remains an appropriate biological model, its identity, purity, ploidy, and phenotype must be maintained. These characteristics comprise and determine the authenticity of a cell line. Routine monitoring of the cell line through microscopic examination of morphology can help to determine authenticity, as can the determination of phenotypic status...
December 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29197027/best-practices-for-detecting-and-mitigating-the-risk-of-cell-culture-contaminants
#17
Raymond W Nims, Paul J Price
A variety of biological and chemical contaminants can adversely impact cells in culture, ranging from outright destruction of the culture, mutation, phenotypic changes to relatively minor changes in morphology, or growth rate. There are various approaches to detecting and mitigating the risk of biological or microbial contaminants in cell cultures, and these are discussed in this article. Chemical contaminants typically arise from improper handling or sourcing of cell culture reagents, glassware, or other types of consumables...
December 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29184027/arabidopsis-vps38-is-required-for-vacuolar-trafficking-but-dispensable-for-autophagy
#18
Han Nim Lee, Xavier Zarza, Jeong Hun Kim, Min Ji Yoon, Sang-Hoon Kim, Jae-Hoon Lee, Nadine Paris, Teun Munnik, Marisa S Otegui, Taijoon Chung
Phosphatidylinositol 3-phosphate (PI3P) is a signaling molecule that controls a variety of processes in endosomal, autophagic and vacuolar/lysosomal trafficking in yeasts and mammals. Vacuolar protein sorting 34 (Vps34) is a conserved phosphatidylinositol 3-kinase (PI3K) present in multiple complexes with specific functions and regulation. In yeast, the PI3K complex II, consisting of Vps34p, Vps15p, Vps30p/Atg6p, and Vps38p, is essential for vacuolar protein sorting. Here, we describe the Arabidopsis thaliana homolog of yeast Vps38p and human UV radiation resistance-associated gene (UVRAG) protein...
November 28, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29162189/altered-ventral-striatal-medial-prefrontal-cortex-resting-state-connectivity-mediates-adolescent-social-problems-after-early-institutional-care
#19
Dominic S Fareri, Laurel Gabard-Durnam, Bonnie Goff, Jessica Flannery, Dylan G Gee, Daniel S Lumian, Christina Caldera, Nim Tottenham
Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29158567/optogenetic-silencing-of-nociceptive-primary-afferents-reduces-evoked-and-ongoing-bladder-pain
#20
Vijay K Samineni, Aaron D Mickle, Jangyeol Yoon, Jose G Grajales-Reyes, Melanie Y Pullen, Kaitlyn E Crawford, Kyung Nim Noh, Graydon B Gereau, Sherri K Vogt, H Henry Lai, John A Rogers, Robert W Gereau
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily relieves pain. Here, we explored the possibility that optogenetic inhibition of nociceptive sensory afferents could be used to modulate bladder pain. The light-activated inhibitory proton pump Archaerhodopsin (Arch) was expressed under control of the sensory neuron-specific sodium channel (sns) gene to selectively silence these neurons...
November 20, 2017: Scientific Reports
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