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https://www.readbyqxmd.com/read/28913661/discovery-of-non-peptidic-small-molecule-inhibitors-of-cyclophilin-d-as-neuroprotective-agents-in-a%C3%AE-induced-mitochondrial-dysfunction
#1
Insun Park, Ashwini M Londhe, Ji Woong Lim, Beoung-Geon Park, Seo Yun Jung, Jae Yeol Lee, Sang Min Lim, Kyoung Tai No, Jiyoun Lee, Ae Nim Pae
Cyclophilin D (CypD) is a mitochondria-specific cyclophilin that is known to play a pivotal role in the formation of the mitochondrial permeability transition pore (mPTP).The formation and opening of the mPTP disrupt mitochondrial homeostasis, cause mitochondrial dysfunction and eventually lead to cell death. Several recent studies have found that CypD promotes the formation of the mPTP upon binding to β amyloid (Aβ) peptides inside brain mitochondria, suggesting that neuronal CypD has a potential to be a promising therapeutic target for Alzheimer's disease (AD)...
September 14, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28893778/a-protocol-for-identifying-natural-agents-that-selectively-affect-adhesion-thickness-architecture-cellular-phenotypes-ecm-and-human-white-cell-impenetrability-of-candida-albicans-biofilms
#2
Yang-Nim Park, Thyagarajan Srikantha, Karla J Daniels, Melissa R Jacob, Ameeta K Agarwal, Xing-Cong Li, David R Soll
In screening natural plant extracts for antifungal activity, assessing the effects on growth of cells in suspension or in the wells of microtiter plates is expedient. However, microorganisms, including Candida albicans, grow in nature as biofilms, organized cellular communities with complex architecture, capable of conditioning their microenvironment, communicating, and excluding low and high molecular weight molecules, and white blood cells. Here, a confocal laser scanning microscopy (CLSM) protocol is described for testing the effects of large numbers of agents on biofilm development...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28879500/in-silico-probing-and-biological-evaluation-of-setdb1-eset-targeted-novel-compounds-that-reduce-tri-methylated-histone-h3k9-h3k9me3-level
#3
Insun Park, Yu Jin Hwang, TaeHun Kim, Ambily Nath Indu Viswanath, Ashwini M Londhe, Seo Yun Jung, Kyoung Mi Sim, Sun-Joon Min, Ji Eun Lee, Jihye Seong, Yun Kyung Kim, Kyoung Tai No, Hoon Ryu, Ae Nim Pae
ERG-associated protein with the SET domain (ESET/SET domain bifurcated 1/SETDB1/KMT1E) is a histone lysine methyltransferase (HKMT) and it preferentially tri-methylates lysine 9 of histone H3 (H3K9me3). SETDB1/ESET leads to heterochromatin condensation and epigenetic gene silencing. These functional changes are reported to correlate with Huntington's disease (HD) progression and mood-related disorders which make SETDB1/ESET a viable drug target. In this context, the present investigation was performed to identify novel peptide-competitive small molecule inhibitors of the SETDB1/ESET by a combined in silico-in vitro approach...
September 6, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28877716/assessing-the-quality-of-reports-about-randomized-controlled-trials-of-scalp-acupuncture-combined-with-another-treatment-for-stroke
#4
Young-Nim You, Myung-Rae Cho, Jae-Hong Kim, Ju-Hyung Park, Gwang-Cheon Park, Min-Yeong Song, Jin-Bong Choi, Jae-Young Han
BACKGROUND: This study was designed to assess the quality of reporting on randomized controlled trials (RCTs) of scalp acupuncture for the treatment of stroke. METHODS: The following 8 databases were systematically investigated from their inception to December 2015: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, National Institute of Informatics Scholarly and Academic Information Navigator, National Digital Science Library, Korean Traditional Knowledge Portal, and Korean Studies Information Service System...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28872065/synthesis-and-characterization-of-cryptand-222-potassium-2-methylimidazolato-meso-tetraphenylporphinato-ferrate-ii-2-methylimidazole-tetrahydrofuran-1-1-2
#5
Qi Wu, Zhen Yao, Jianfeng Li
Metalloporphyrin complexes containing an additional imidazole ligand can provide information about the effect of deprotonation or hydrogen bonding on the axial histidine unit in heme proteins. The title high-spin five-coordinate imidazolate-ligated iron(II) porphyrinate, [K(C18H36N2O6)][Fe(C4H5N2)(C44H28N4)]·C4H6N2·2C4H8O, has been synthesized and investigated. The solvated salt crystallizes with one 2-methylimidazole molecule, two tetrahydrofuran solvent molecules and a potassium cation chelated inside a cryptand-222 (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8...
September 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28869827/effects-of-dexamethasone-and-nimesulide-on-bisphosphonate-related-osteonecrosis-of-the-jaw-an-experimental-study
#6
Camila Carvalho de Oliveira, Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira, Romélia Pinheiro Gonçalves, Fabrício Bitu de Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
OBJECTIVE: To evaluate the effects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. DESIGN: BRONJ was induced by zoledronic acid (ZA) infusion (0.2mg/kg) in Wistar rats (n=8), followed by extraction of the left lower first molar (BRONJ groups). Control groups (n=40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4mg/kg) or saline (SAL) were administered by gavage 24h before each infusion of ZA or saline (IV), or NIM (10...
August 30, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28861817/using-homology-modeling-to-understand-the-structural-basis-of-specific-interaction-of-a-plant-specific-atsar1a-atsec23a-pair-involved-in-protein-er-export
#7
Yap-Shing Nim, Shuangli Sun, Kam-Bo Wong
Homology modeling allows the prediction of a protein structure based on sequence similarity to a known structure of homologous proteins. In this chapter, we use a plant-specific AtSar1a-Atsec23a pair of proteins as a case study to illustrate how to use homology modeling to understand the specificity of the pairwise interaction between AtSar1a and AtSec23a. The detailed procedures described here are also useful in structure prediction of other protein complexes.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28846591/identification-of-optically-active-pyrimidine-derivatives-as-selective-5-ht2c-modulators
#8
Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
A series of pyrimidine derivatives 4a-i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a-i, the influence of the size of alkyl ether and the absolute configuration of a stereogenic center on the 5-HT2C binding affinity and selectivity was studied. The most promising diasteromeric mixtures 4d and 4e were selected in the initial radioligand binding assay and they were further synthesized as optically active forms starting from optically active alcohols 5d and 5e, prepared by an enzymatic kinetic resolution...
August 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28840093/nim-gene-independent-metronidazole-resistant-bacteroides-fragilis-in-surgical-site-infections
#9
Mohammad Taghi Akhi, Reza Ghotaslou, Naser Alizadeh, Mina Yekani, Samad Beheshtirouy, Mohammad Asgharzadeh, Tahereh Pirzadeh, Mohammad Yousef Memar
Background:Bacteroides fragilis is the most common anaerobic pathogen isolated from surgical site infections (SSIs). Metronidazole resistance is increasing and the mechanisms of resistance are not clear in some isolates. The aim of the present study was to investigate the metronidazole susceptibility prevalence, and detect nim genes in B. fragilis isolates from SSIs. Methods: This study included 100 surgery patients with signs and symptoms indicative of SSIs. Syringe aspiration of the infected site was used to collect specimens...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28836774/new-titanium-borylimido-compounds-synthesis-structure-and-bonding
#10
Benjamin A Clough, Simona Mellino, Andrey V Protchenko, Martin Slusarczyk, Laura C Stevenson, Matthew P Blake, Bowen Xie, Eric Clot, Philip Mountford
We report a combined experimental and computational study of the synthesis and electronic structure of titanium borylimido compounds. Three new synthetic routes to this hitherto almost unknown class of Group 4 imide are presented. The double-deprotonation reaction of the borylamine H2NB(NAr'CH)2 (Ar' = 2,6-C6H3(i)Pr2) with Ti(NMe2)2Cl2 gave Ti{NB(NAr'CH)2}Cl2(NHMe2)2, which was easily converted to Ti{NB(NAr'CH)2}Cl2(py)3. This compound is an entry point to other borylimides, for example, reacting with Li2N2(pyr)N(Me) to form Ti(N2(pyr)N(Me)){NB(NAr'CH)2}(py)2 and with 2 equiv of NaCp to give Cp2Ti{NB(NAr'CH)2}(py) (23)...
August 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28830728/the-large-area-multi-wire-proportional-counting-system-for-2%C3%AF-alpha-and-beta-emission-measurement-at-the-nim-china
#11
Junwei Zhang, Ming Zhang, Limin Duan, Zheng Tu, Zhijie Yang, Yuqi Li, Juncheng Liang, Haoran Liu
An alpha/beta emission rate counting system which comprises of a large-area windowless multi-wire proportional counter and a digital pulse processing module has been established at the National Institute of Metrology of China, aiming at realizing the absolute measurement of emission rate for alpha and beta sources. Performance of the detector, including high-voltage plateaus and uniformity were measured. Measured emission rates for large-area (241)Am and (90)Sr/(90)Y sources when compared with certificated values showed difference within 1...
August 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28830626/aquaculture-and-urban-marine-structures-facilitate-native-and-non-indigenous-species-transfer-through-generation-and-accumulation-of-marine-debris
#12
Marnie L Campbell, Staci King, Lara D Heppenstall, Ella van Gool, Ross Martin, Chad L Hewitt
Both the invasion of non-indigenous marine species (NIMS) and the generation and accumulation of anthropogenic marine debris (AMD) are pervasive problems in coastal urban ecosystems. The biosecurity risks associated with AMD rafting NIMS have been described, but the role of aquaculture derived AMD has not yet been investigated as a biosecurity vector and pathway. This preliminary study targeted 27 beaches along the Coromandel Peninsula, New Zealand, collecting debris from belt transects. Plastic (specifically plastic rope) was the dominant AMD present on beaches...
August 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28822253/clout-or-doubt-perspectives-on-an-infant-mental-health-service-for-young-children-placed-in-foster-care-due-to-abuse-and-neglect
#13
Fiona Turner-Halliday, Gary Kainth, Genevieve Young-Southward, Richard Cotmore, Nicholas Watson, Lynn McMahon, Helen Minnis
Despite knowledge about the profound effects of child abuse and neglect, we know little about how best to assess whether maltreated children should return home. The effectiveness of the New Orleans Intervention Model (NIM) is being tested in a randomized controlled trial where the comparison is social work 'services as usual.' The future trial results will tell us which approach produces the best outcomes for children; meanwhile qualitative process evaluation is generating intriguing findings about the perceived impact of NIM on decision-making about childrens' futures...
August 16, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28808859/best-practices-in-cell-culture-an-overview
#14
John M Baust, Gertrude Case Buehring, Lia Campbell, Eugene Elmore, John W Harbell, Raymond W Nims, Paul Price, Yvonne A Reid, Frank Simione
This overview describes a series of articles to provide an unmet need for information on best practices in animal cell culture. The target audience primarily consists of entry-level scientists with minimal experience in cell culture. It also include scientists, journalists, and educators with some experience in cell culture, but in need of a refresher in best practices. The articles will be published in this journal over a six-month period and will emphasize best practices in: (1) media selection; (2) use and evaluation of animal serum as a component of cell culture medium; (3) receipt of new cells into the laboratory; (4) naming cell lines; (5) authenticating cell line identity; (6) detecting and mitigating risk of cell culture contamination; (7) cryopreservation and thawing of cells; and (8) storing and shipping viable cells...
August 14, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28753954/isoegomaketone-alleviates-the-development-of-collagen-antibody-induced-arthritis-in-male-balb-c-mice
#15
Chang Hyun Jin, Yangkang So, Bomi Nam, Sung Nim Han, Jin-Baek Kim
In this study, we attempted to identify and assess effects of isoegomaketone (IK) isolated from Perilla frutescens var. crispa on the development of rheumatoid arthritis (RA). RA was induced in male Balb/c mice by collagen antibody injection. Experimental animals were randomly divided into five groups: normal, collagen antibody-induced arthritis (CAIA), CAIA + IK (5 mg/kg/day), CAIA + IK (10 mg/kg/day), and CAIA + apigenin (16 mg/kg/day) and respective treatments were administered via oral gavage once per day for four days...
July 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28733930/best-practices-for-the-use-and-evaluation-of-animal-serum-as-a-component-of-cell-culture-medium
#16
Raymond W Nims, John W Harbell
Animal serum is a common additive for cell culture medium and is often required at 5 to 10% (v/v) for the attachment and growth of primary and continuous anchorage-dependent (monolayer) cultures. The use of animal serum in cell culture medium confers several advantages and also some risks. This article discusses the use of animal serum as a component of cell culture medium. The best practices associated with the sourcing, storage, thawing, testing, and mitigation of risk associated with the use of animal sera are among the topics described in this article...
July 21, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28717779/impact-of-middle-east-respiratory-syndrome-outbreak-on-the-use-of-emergency-medical-resources-in-febrile-patients
#17
Hyunho Jeong, Sikyoung Jeong, Juseok Oh, Seon Hee Woo, Byung Hak So, Jeong Hee Wee, Ji Hoon Kim, Ji Yong Im, Seung Pill Choi, Kyoungnam Park, Byul Nim Hee Cho, Sungyoup Hong
OBJECTIVE: Outbreaks of transmissible respiratory infection are suspected to have significant effects on the health of pediatric and geriatric patients. The objective was to assess the impact of the Middle East respiratory syndrome (MERS) outbreak on the use of emergency resources. METHODS: An ecologic analysis of emergency department (ED) records between September and December 2015, was performed. Data was obtained from the National Emergency Department Information System database for Korea...
June 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28686860/muscle-stem-cells-undergo-extensive-clonal-drift-during-tissue-growth-via-meox1-mediated-induction-of-g2-cell-cycle-arrest
#18
Phong Dang Nguyen, David Baruch Gurevich, Carmen Sonntag, Lucy Hersey, Sara Alaei, Hieu Tri Nim, Ashley Siegel, Thomas Edward Hall, Fernando Jaime Rossello, Sarah Elizabeth Boyd, Jose Maria Polo, Peter David Currie
Organ growth requires a careful balance between stem cell self-renewal and lineage commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that mediate this balance are unresolved in most organs, including skeletal muscle. Here we identify a long-lived stem cell pool that mediates growth of the zebrafish myotome. This population exhibits extensive clonal drift, shifting from random deployment of stem cells during development to reliance on a small number of dominant clones to fuel the vast majority of muscle growth...
July 6, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28664382/direct-determination-of-nimesulide-in-natural-waters-and-wastewater-by-cathodic-stripping-voltammetry
#19
Luciane Miranda, Vanessa C Pereira, Christiane S Machado, Yohandra R Torres, Vanessa E Dos Anjos, Sueli P Quináia
Pharmaceuticals are included in a group of compounds considered as contaminants of emerging concern (CECs) in environmental matrices. The quantification of CECs is typically accomplished using chromatographic methods that require several sample pretreatment steps. The current study proposes a voltammetric method to quantify directly nimesulide (NIM) in aqueous samples. The voltammetric parameters were optimized and chosen based on the profile of the voltammograms and peak current intensity. The adequacy of the analytical method was evaluated using validation criteria, such as accuracy, selectivity, linearity, detection, and quantification limits...
June 29, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28660722/in-silico-designed-novel-non-peptidic-abad-ld-hot-spot-mimetics-reverse-a%C3%AE-induced-mitochondrial-impairments-in-vitro
#20
Ambily Nath Indu Viswanath, TaeHun Kim, Seo Yun Jung, Sang Min Lim, Ae Nim Pae
Present work aimed to introduce non-peptidic ABAD loop D (LD ) hot spot mimetics as ABAD-Aβ inhibitors. A full-length atomistic model of ABAD-Aβ complex was built as a scaffold to launch the lead design and its topology later verified by cross-checking the computational mutagenesis results with that of in vitro data. Thereafter, the interactions of prime Aβ-binding LD residues-Tyr101, Thr108, and Thr110-were translated into specific pharmacophore features and this hypothesis subsequently used as a virtual screen query...
June 29, 2017: Chemical Biology & Drug Design
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