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https://www.readbyqxmd.com/read/27911798/stretchable-multichannel-antennas-in-soft-wireless-optoelectronic-implants-for-optogenetics
#1
Sung Il Park, Gunchul Shin, Jordan G McCall, Ream Al-Hasani, Aaron Norris, Li Xia, Daniel S Brenner, Kyung Nim Noh, Sang Yun Bang, Dionnet L Bhatti, Kyung-In Jang, Seung-Kyun Kang, Aaron D Mickle, Gregory Dussor, Theodore J Price, Robert W Gereau, Michael R Bruchas, John A Rogers
Optogenetic methods to modulate cells and signaling pathways via targeted expression and activation of light-sensitive proteins have greatly accelerated the process of mapping complex neural circuits and defining their roles in physiological and pathological contexts. Recently demonstrated technologies based on injectable, microscale inorganic light-emitting diodes (μ-ILEDs) with wireless control and power delivery strategies offer important functionality in such experiments, by eliminating the external tethers associated with traditional fiber optic approaches...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27910914/in-vivo-stepwise-immunomodulation-using-chitosan-nanoparticles-as-a-platform-nanotechnology-for-cancer-immunotherapy
#2
Hee Dong Han, Yeongseon Byeon, Jong-Hwa Jang, Hat Nim Jeon, Ga Hee Kim, Min Gi Kim, Chan-Gi Pack, Tae Heung Kang, In Duk Jung, Yong Taik Lim, Young Joo Lee, Jeong-Won Lee, Byung Cheol Shin, Hyung Jun Ahn, Anil K Sood, Yeong-Min Park
Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines to bypass the ex vivo manipulation and induce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890724/clinical-characteristics-and-antimicrobial-susceptibilities-of-anaerobic-bacteremia-in-an-acute-care-hospital
#3
Thean Yen Tan, Lily Siew Yong Ng, Lee Ling Kwang, Suma Rao, Li Ching Eng
: This study investigated the clinical features of anaerobic bacteraemia in an acute-care hospital, and evaluated the antimicrobial susceptibility of these isolates to commonly available antibiotics. MATERIALS & METHODS: Microbiological and epidemiological data from 2009-2011were extracted from the laboratory information system and electronic medical records. One hundred and eleven unique patient episodes consisting of 116 anaerobic isolates were selected for clinical review and antibiotic susceptibility testing...
November 24, 2016: Anaerobe
https://www.readbyqxmd.com/read/27873209/large-scale-interaction-profiling-of-protein-domains-through-proteomic-peptide-phage-display-using-custom-peptidomes
#4
Moon-Hyeong Seo, Satra Nim, Jouhyun Jeon, Philip M Kim
Protein-protein interactions are essential to cellular functions and signaling pathways. We recently combined bioinformatics and custom oligonucleotide arrays to construct custom-made peptide-phage libraries for screening peptide-protein interactions, an approach we call proteomic peptide-phage display (ProP-PD). In this chapter, we describe protocols for phage display for the identification of natural peptide binders for a given protein. We finally describe deep sequencing for the analysis of the proteomic peptide-phage display...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27855359/discovery-of-benzimidazole-derivatives-as-modulators-of-mitochondrial-function-a-potential-treatment-for-alzheimer-s-disease
#5
TaeHun Kim, Ha Yun Yang, Beoung Gun Park, Seo Yun Jung, Jong-Hyun Park, Ki Duk Park, Sun-Joon Min, Jinsung Tae, Hyejin Yang, Suengmok Cho, Sung Jin Cho, Hyundong Song, Inhee Mook-Jung, Jiyoun Lee, Ae Nim Pae
In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD...
November 9, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27836777/anticancer-effects-of-ixeris-dentata-thunb-ex-thunb-nakai-extract-on-human-melanoma-cells-a375p-and-a375sm
#6
Hae Nim Lee, Seong Ah Shin, Gang Sik Choo, Hyeong Jin Kim, Young Seok Park, Byung Kwon Park, Byeong Soo Kim, Sang Ki Kim, Sung Dae Cho, Jeong Seok Nam, Chang Sun Choi, Ji Youn Jung
ETHNOPHARMACOLOGICAL RELEVANCE: The plant species Taraxacum coreanum (TC), Youngia sonchifolia (YS), and Ixeris dentata (ID) belong to the family Compositae and are used for medicinal purposes in traditional medicine. However, the anticancer effects of TC, YS, and ID extracts and the underlying molecular mechanisms in melanoma cells have not been elucidated. AIM OF THE STUDY: To investigate the potential anticancer effects of TC, YS, and ID extracts on human melanoma cells and explore the potential pharmacological mechanisms in vitro and in vivo...
November 8, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27832570/novel-customisation-of-a-nim-sup-tm-sup-emg-tube-to-bypass-distal-airway-obstruction-from-a-massive-retrosternal-goitre
#7
P K Lee, Awg Booth
No abstract text is available yet for this article.
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27818219/removal-of-oxidatively-generated-dna-damage-by-overlapping-repair-pathways
#8
REVIEW
Vladimir Shafirovich, Nicholas E Geacintov
It is generally believed that the mammalian nucleotide excision repair pathway removes DNA helix-distorting bulky DNA lesions, while small non-bulky lesions are repaired by base excision repair (BER). However, recent work demonstrates that the oxidativly generated guanine oxidation products, spiroimininodihydantoin (Sp), 5-guanidinohydantoin (Gh), and certain intrastrand cross-linked lesions, are good substrates of NER and BER pathways that compete with one another in human cell extracts. The oxidation of guanine by peroxynitrite is known to generate 5-guanidino-4-nitroimidazole (NIm) which is structurally similar to Gh, except that the 4-nitro group in NIm is replaced by a keto group in Gh...
November 4, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27803838/sensing-estrogen-with-electrochemical-impedance-spectroscopy
#9
Jing Li, Byung Kun Kim, Kang-Kyun Wang, Ji-Eun Im, Han Nim Choi, Dong-Hwan Kim, Seong In Cho, Won-Yong Lee, Yong-Rok Kim
This study demonstrates the application feasibility of electrochemical impedance spectroscopy (EIS) in measuring estrogen (17β-estradiol) in gas phase. The present biosensor gives a linear response (R(2) = 0.999) for 17β-estradiol vapor concentration from 3.7 ng/L to 3.7 × 10(-4) ng/L with a limit of detection (3.7 × 10(-4) ng/L). The results show that the fabricated biosensor demonstrates better detection limit of 17β-estradiol in gas phase than the previous report with GC-MS method. This estrogen biosensor has many potential applications for on-site detection of a variety of endocrine disrupting compounds (EDCs) in the gas phase...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27793401/near-infrared-intraoperative-molecular-imaging-can-locate-metastases-to-the-lung
#10
Jane Keating, Andrew Newton, Ollin Venegas, Sarah Nims, Ryan Zeh, Jarrod Predina, Charuhas Deshpande, John Kucharczuk, Shuming Nie, E James Delikatny, Sunil Singhal
BACKGROUND: Pulmonary metastasectomy is widely accepted for many tumor types because it may prolong survival and potentially cure some patients. However, intraoperative localization of pulmonary metastases can be technically challenging. We propose that intraoperative near-infrared (NIR) molecular imaging can be used as an adjunct during disease localization. METHODS: We inoculated 50 C57BL/6 mice with Lewis lung carcinoma (LLC) flank tumors. After flank tumor growth, mice were injected through the tail vein with indocyanine green (ICG) before operation, and intraoperative imaging was used to detect pulmonary metastases...
October 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27776296/transcriptional-and-cellular-effects-of-non-steroidal-anti-inflammatory-drugs-nsaids-in-experimentally-exposed-mussels-mytilus-galloprovincialis
#11
M Mezzelani, S Gorbi, D Fattorini, G d'Errico, M Benedetti, M Milan, L Bargelloni, F Regoli
The aim of the present investigation was to provide new insights on accumulation and possible adverse effects of various non-steroidal anti-inflammatory drugs (NSAIDs) in mussels, Mytilus galloprovincialis, exposed to an environmentally realistic concentration (0.5μg/L) of individual compounds, Acetaminophen (AMP), Diclofenac (DIC), Ibuprofen (IBU), Ketoprofen (KET) or Nimesulide (NIM). The measurement of drugs in mussel tissues was integrated with both functional alterations at cellular level and transcriptomic responses...
November 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27741220/intraoperative-near-infrared-optical-imaging-can-localize-gadolinium-enhancing-gliomas-during-surgery
#12
John Y K Lee, Jayesh P Thawani, John Pierce, Ryan Zeh, Maria Martinez-Lage, Michelle Chanin, Ollin Venegas, Sarah Nims, Kim Learned, Jane Keating, Sunil Singhal
BACKGROUND: Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE: To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and clinical investigations, in order to localize tumors and to potentially identify residual disease. METHODS: Fifteen patients were identified and administered a Food and Drug Administration-approved, NIR contrast agent (Second Window indocyanine green [ICG], 5 mg/kg) before surgical resection...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27733733/occupational-safety-and-health-system-for-workers-engaged-in-emergency-response-operations-in-the-usa
#13
Hiroyuki Toyoda, Tatsuhiko Kubo, Koji Mori
OBJECTIVES: To study the occupational safety and health systems used for emergency response workers in the USA, we performed interviews with related federal agencies and conducted research on related studies. METHODS: We visited the Federal Emergency Management Agency (FEMA) and National Institute for Occupational Safety and Health (NIOSH) in the USA and performed interviews with their managers on the agencies' roles in the national emergency response system. We also obtained information prepared for our visit from the USA's Occupational Safety and Health Administration (OSHA)...
October 12, 2016: Sangyō Eiseigaku Zasshi, Journal of Occupational Health
https://www.readbyqxmd.com/read/27733455/venous-access-and-long-term-pacemaker-lead-failure-comparing-contrast-guided-axillary-vein-puncture-with-subclavian-puncture-and-cephalic-cutdown
#14
Ngai-Yin Chan, Nim-Pong Kwong, Adrian-Piers Cheong
AIMS: Existing data on the relationship between venous access and long-term pacemaker lead failure (PLF) are scarce and inconsistent. We aim to study the hypothesis that contrast-guided axillary vein puncture (AP) is better than subclavian puncture (SP) and similar to cephalic vein cutdown (CV) in the incidence of PLF and the success rate of AP is higher than CV. METHODS AND RESULTS: The case records of 409 patients with 681 implantable pacemaker leads were reviewed...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27730765/intraoperative-motor-evoked-potential-disappearance-versus-amplitude-decrement-alarm-criteria-during-cervical-spinal-surgery-a-long-term-prognosis
#15
Dong Gun Kim, Young Doo Choi, Seung Hyun Jin, Chi Heon Kim, Kwang Woo Lee, Kyung Seok Park, Chun Kee Chung, Sung Min Kim
BACKGROUND AND PURPOSE: We studied the clinical significance of amplitude-reduction and disappearance alarm criteria for transcranial electric muscle motor-evoked potentials (MEPs) during cervical spinal surgery according to different lesion locations [intramedullary (IM) vs. nonintramedullary (NIM)] by evaluating the long-term postoperative motor status. METHODS: In total, 723 patients were retrospectively dichotomized into the IM and NIM groups. Each limb was analyzed respectively...
October 7, 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27728054/clinical-etiological-and-echocardiographic-profile-and-short-term-outcome-of-infective-endocarditis-nims-experience
#16
C Guruchaithanya Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27724972/scalp-acupuncture-and-electromagnetic-convergence-stimulation-for-patients-with-cerebral-infarction-study-protocol-for-a-randomized-controlled-trial
#17
Jae-Young Han, Jae-Hong Kim, Ju-Hyung Park, Min-Yeong Song, Min-Keun Song, Dong-Joo Kim, Young-Nim You, Gwang-Cheon Park, Jin-Bong Choi, Myung-Rae Cho, Jeong-Cheol Shin, Ji-Hyun Cho
BACKGROUND: Scalp acupuncture (SA) and repetitive transcranial magnetic stimulation (rTMS) are effective for treating cerebral infarction. This study aims to examine the efficacy and safety of SA and electromagnetic convergence stimulation (SAEM-CS), which was developed through collaboration between conventional medical physicians and doctors who practice traditional Korean medicine. SAEM-CS was designed to improve function in patients with cerebral infarction, compared to the improvement after conventional stroke rehabilitation, SA, and rTMS therapeutic approaches...
October 11, 2016: Trials
https://www.readbyqxmd.com/read/27718378/nonlinear-imaging-nim-of-flaws-in-a-complex-composite-stiffened-panel-using-a-constructive-nonlinear-array-cna-technique
#18
Gian Piero Malfense Fierro, Michele Meo
Recently, there has been high interest in the capabilities of nonlinear ultrasound techniques for damage/defect detection as these techniques have been shown to be quite accurate in imaging some particular type of damage. This paper presents a Constructive Nonlinear Array (CNA) method, for the detection and imaging of material defects/damage in a complex composite stiffened panel. CNA requires the construction of an ultrasound array in a similar manner to standard phased arrays systems, which require multiple transmitting and receiving elements...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27709016/effect-of-age-on-the-pharmacokinetics-of-polymorphic-nimodipine-in-rats-after-oral-administration
#19
Wenli Liu, Xiaona Wang, Ruilian Chen, Kaixuan Zhang, Yao Li, Yi Li, Duanyun Si, Junbo Gong, Dianshu Yin, Yongli Wang, Zhenping Wei, Mingshi Yang
The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats...
September 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27698954/korean-pine-nut-oil-replacement-decreases-intestinal-lipid-uptake-while-improves-hepatic-lipid-metabolism-in-mice
#20
Shuang Zhu, Soyoung Park, Yeseo Lim, Sunhye Shin, Sung Nim Han
BACKGROUND/OBJECTIVES: Consumption of pine nut oil (PNO) was shown to reduce weight gain and attenuate hepatic steatosis in mice fed a high-fat diet (HFD). The aim of this study was to examine the effects of PNO on both intestinal and hepatic lipid metabolism in mice fed control or HFD. MATERIALS/METHODS: Five-week-old C57BL/6 mice were fed control diets containing 10% energy fat from either Soybean Oil (SBO) or PNO, or HFD containing 15% energy fat from lard and 30% energy fat from SBO or PNO for 12 weeks...
October 2016: Nutrition Research and Practice
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