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https://www.readbyqxmd.com/read/28938539/dissemination-of-macrolides-fusidic-acid-and-mupirocin-resistance-among-staphylococcus-aureus-clinical-isolates
#1
Xingmei Liu, Shanshan Deng, Jinwei Huang, Yaling Huang, Yu Zhang, Qin Yan, Yanhong Wang, Yanyue Li, Chengfu Sun, Xu Jia
As an increasingly common cause of skin infections worldwide, the prevalence of antibiotic-resistant Staphylococcus aureus (S. aureus) across China has not been well documented. This literature aims to study the resistance profile to commonly used antibiotics, including macrolides, fusidic acid (FA) and mupirocin, and its relationship to the genetic typing in 34 S. aureus strains, including 6 methicillin-resistant S. aureus (MRSA), isolated from a Chinese hospital. The MIC results showed 27 (79.4%), 1 (2.9%) and 6 (17...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938286/optimizing-bone-defect-reconstruction-balanced-cable-transport-with-circular-external-fixation
#2
Stephen Matthew Quinnan, Charles Lawrie
Distraction osteogenesis has proven effective in the management of tibial bone loss from severe trauma and infection. Unfortunately, pain and scarring from wires and half pins dragging through the skin and the required prolonged time in the external fixator make treatment difficult. Cable bone transport has been shown to improve cosmesis and decrease pain during transport. However, the published methods have limitations in that they have poor control of transport segment alignment, do not allow for lengthening of the limb, and do not permit weight bearing during the treatment process...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#3
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28937438/cutaneous-cytomegalovirus-infection-in-an-immunocompetent-patient-innocent-bystander-or-culprit
#4
Solomiya Grushchak, Kelli A Hutchens, Cossette Joy, Anthony Peterson, Jodi Speiser, Kumaran Mudaliar
We present a rare case of cutaneous cytomegalovirus (CMV) infection in a nonimmunocompromised patient. A 74-year-old woman with a history of diabetes presented with an ulcer on the right lateral tibia that occurred at the site of a nerve core biopsy. Subsequent biopsy of the ulcer edge showed granulation tissue with neutrophilic inflammation. The patient underwent extensive antibiotic treatment for possible infection with weekly wound care. However, the ulceration persisted and enlarged. A repeat biopsy 1 year later showed superficial and deep mixed inflammation with an associated vasculitis...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28937303/palliative-coverage-of-cranial-defect-following-failed-cranial-flap-for-advanced-squamous-cell-carcinoma-case-report
#5
Vyacheslav Makler, Jeffrey S Litt, N Scott Litofsky
INTRODUCTION: With advanced-stage head and neck cancers, patients may develop large and/or complex wounds despite multiple reconstruction attempts. Wound coverage may require novel approaches to palliate the patient. METHOD: We present the case of a 56-year-old female with advanced squamous cell carcinoma of the scalp and skull who required multiple surgical interventions. Despite our best reconstructive efforts, the patient subsequently developed scalp infection and sepsis, necessitating further debridement for source control...
September 22, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28935523/an-outbreak-of-burkholderia-cepacia-pseudobacteraemia-caused-by-intrinsically-contaminated-commercial-0-5-chlorhexidine-solution-in-neonatal-intensive-care-units
#6
Je Eun Song, Yee Gyung Kwak, Tae Hyun Um, Chong Rae Cho, Sollip Kim, In Sook Park, Jong Hee Hwang, Namhee Kim, Gang-Bok Oh
BACKGROUND: Burkholderia cepacia is intrinsically resistant to certain antiseptics. We experienced a sudden increase in the frequency of isolation of B. cepacia from blood cultures in a neonatal intensive care unit (NICU) of a university-affiliated hospital. AIM: An investigation was conducted to identify the source and to intervene in the ongoing infections. METHODS: The cases were defined as patients with positive blood cultures for B. cepacia in a NICU between November 2014 and January 2015...
September 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28935337/necrotizing-sweet-syndrome-of-the-upper-extremity-after-elective-hand-surgery
#7
Jason S Lipof, Lisa A Beck, Swapna C Reddy, Richard D Southgate, Kimberly Carney-Young, Warren C Hammert
Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response to cutaneous trauma resulting in a propagation of the disease. In contrast to a necrotizing infection, this condition responds to systemic steroids...
September 19, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28934859/antibacterial-and-anticancer-activity-of-the-purified-cashew-nut-shell-liquid-implications-in-cancer-chemotherapy-and-wound-healing
#8
Shabeeba M Ashraf, Krishnan Rathinasamy
The cashew nut shell liquid (CNSL) from the cashew nut shell of Anacardium occidentale L. has been used to treat skin infections, cracks on soles of feet and cancerous ulcers. In this study, we have purified the technical CNSL, systematically evaluated its anticancer, antibacterial and wound healing activity. The LC-MS data revealed that the purified CNSL contains the compounds, cardanol, anacardic acid and methylcardol. It inhibited the proliferation of HeLa cells with an IC50 of 0.004%(v/v) and caused moderate mitotic block with spindle abnormality...
September 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28934824/acid-fastness-of-histoplasma-in-surgical-pathology-practice
#9
Madhu Rajeshwari, Immaculata Xess, Mehar Chand Sharma, Deepali Jain
BACKGROUND: Histoplasmosis (HP) is diagnosed by visualizing intracellular microorganisms in biopsy and/or culture. Periodic-acid Schiff (PAS) and Gomori methenamine silver (GMS) staining methods are routinely used for identification. The acid-fast property of Histoplasma was identified decades ago, but acid-fast staining has not been practiced in current surgical pathology. Awareness of the acid-fast property of Histoplasma, which is due to mycolic acid in the cell wall, is important in distinguishing Histoplasma from other infective microorganisms...
September 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28934511/multi-drug-resistant-surgical-site-infection-due-to-mycobacterium-abscessus-complex
#10
Richa Misra, Vidhi Jain, Nidhi Tejan, Aarti Negi, Jyoti Umrao, Tapan Nirodhechand Dhole
M. abscessus complex is notoriously resistant to most antimicrobial agents. The complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. Skin and soft tissue infections due to this organism can be acquired by direct contact with contaminated material through traumatic injury, surgical wound and environmental exposure or by secondary involvement of skin/soft tissue during disseminated disease. We report a case of Mycobacterium abscessus infection recovered from a post-operative mid-line abdominal wound to illustrate the diagnostic and management difficulties encountered in such patients...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934228/knowledge-about-tuberculosis-transmission-and-prevention-and-perceptions-of-health-service-utilization-among-index-cases-and-contacts-in-brazil-understanding-losses-in-the-latent-tuberculosis-cascade-of-care
#11
Flavia Matos Salame, Márcia Danielle Ferreira, Marcia Teresa Belo, Eleny Guimarães Teixeira, Marcelo Cordeiro-Santos, Ricardo Arraes Ximenes, Maria de Fátima Militão de Albuquerque, Philip C Hill, Dick Menzies, Anete Trajman
INTRODUCTION: Tuberculosis contacts are candidates for active and latent tuberculosis infection screening and eventual treatment. However, many losses occur in the different steps of the contacts' cascade of care. Reasons for this are poorly understood. OBJECTIVE: To describe the different steps where losses in the contact cascade occur and to explore knowledge and attitudes regarding tuberculosis transmission/prevention and perceptions about tuberculosis services in order to understand the reasons for losses from the tuberculosis service users' perspective...
2017: PloS One
https://www.readbyqxmd.com/read/28934124/n-halamine-biocidal-materials-with-superior-antimicrobial-efficacies-for-wound-dressings
#12
Buket Demir, Roy M Broughton, Mingyu Qiao, Tung-Shi Huang, S D Worley
This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28933975/foot-problems-in-older-women
#13
F Guidozzi
Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated with other co-morbid diseases of the foot...
September 21, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28933509/-targeting-the-skin-erythema-multiforme-in-dogs-and-cats
#14
Ralf Mueller, Teresa M S A Boehm, Christoph J Klinger, Laura Udraite, Ralf S Mueller
This review article will describe the complex nature of erythema multiforme in dogs and cats. The disease pattern will be illustrated in terms of etiology, pathogenesis, clinical signs, diagnostics and therapy. Erythema multiforme is a rare, immune-mediated skin disorder with an acute specific reaction pattern of skin and mucous membranes against different underlying causes. Reported triggering factors include drugs, food ingredients and neoplasias, but viral or bacterial infections and vaccine reactions were also identified...
September 20, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28932812/comparison-of-the-microbiota-of-older-adults-living-in-nursing-homes-and-the-community
#15
Mary-Claire Roghmann, Alison D Lydecker, Lauren Hittle, Robert T DeBoy, Rebecca G Nowak, J Kristie Johnson, Emmanuel F Mongodin
Our objective for this study was to characterize the microbial communities of the anterior nares (nose), posterior pharynx (throat), and skin of the femoral and subclavian areas in older adults from nursing homes and the community. Older adults (≥65 years) without antibiotic use for the past 3 months were recruited from nursing homes (NH; n = 16) and from the community (CB; n = 51). Specimens were taken from nose, throat, and skin sites for culture and bacterial profiling using 16S rRNA gene sequencing...
September 2017: MSphere
https://www.readbyqxmd.com/read/28932687/multifocal-ulceronecrotic-skin-lesions-a-stigmatizing-case
#16
Fanny-Emmanuelle Bernier, Simon Grandjean Lapierre, Arwa El-Housseini, Mélissa Nantel-Battista, Sapha Barkati
Mycobacterium chelonae is a rapidly growing nontuberculous mycobacteria, ubiquitous in the environment and mostly involved in skin, soft tissue and bone infections. An atypical, severe and multifocal dermatological manifestation of Mycobacterium chelonae infection in an immunocompetent patient is described here. The lesions completely resolved using a multidisciplinary approach. This case emphasizes the important aspects of diagnosis, antimicrobial and surgical management.
2017: IDCases
https://www.readbyqxmd.com/read/28932266/risk-factors-for-surgical-site-infections-in-obstetrics-a-retrospective-study-in-an-ethiopian-referral-hospital
#17
Teshager Mamo, Tilaye Workneh Abebe, Tesfaye Yitna Chichiabellu, Antehun Alemayehu Anjulo
BACKGROUND: Pregnant women are at risk of infection during labor and delivery. Infection in obstetrics accounts for the second most common cause of maternal mortality next to post partum hemorrhage. Knowing the prevalence and associated risk factors would help to undertake optimal precautions and standard surgical techniques to reduce surgical site infection which poses increased hospital cost and total hospital stay of the patients. METHOD: Facility based retrospective observational study design was carried out purposively to assess the prevalence of surgical site infections and associated risk factors among mothers who had delivery related surgery at obstetric ward of Assela teaching referral hospital from April, 23, 2015 to September 5, 2015...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28931602/an-anti-inflammatory-role-for-nlrp10-in-murine-cutaneous-leishmaniasis
#18
Gwendolyn M Clay, Diogo G Valadares, Joel W Graff, Tyler K Ulland, Richard E Davis, Breanna M Scorza, Bayan Sudan Zhanbolat, Yani Chen, Fayyaz S Sutterwala, Mary E Wilson
The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection. There was no evidence that the enhanced local inflammation was due to enhanced inflammasome activity. NLRP10/DOCK8-deficient mice harbored lower parasite burdens at the cutaneous site of inoculation compared with wild-type controls, whereas NLRP10-deficient mice and controls had similar parasite loads, suggesting that DOCK8 promotes local growth of parasites in the skin, whereas NLRP10 does not...
September 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28931203/scalpel-versus-electrosurgery-for-major-abdominal-incisions
#19
REVIEW
Kittipat Charoenkwan, Zipporah Iheozor-Ejiofor, Kittipan Rerkasem, Elizabeth Matovinovic
BACKGROUND: Scalpels or electrosurgery can be used to make abdominal incisions. The potential benefits of electrosurgery may include reduced blood loss, dry and rapid separation of tissue, and reduced risk of cutting injury to surgeons. Postsurgery risks possibly associated with electrosurgery may include poor wound healing and complications such as surgical site infection. OBJECTIVES: To assess the effects of electrosurgery compared with scalpel for major abdominal incisions...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28931145/medical-and-psychological-problems-faced-by-young-australian-gap-year-travellers
#20
Luis Furuya-Kanamori, Deborah Mills, Sarah Sheridan, Colleen Lau
Background: Gap year travellers can potentially be exposed to many infectious diseases and other travel-related health problems including injuries and psychological problems. Currently, there is little information on health and wellbeing of this particular group of travellers. Methods: Participants were recruited from an organization that specialized in organising international gap year placements. Gap year travellers were asked to complete a pre-departure survey on demographics, placement destination and duration, previous travel experience, hobbies, risk taking behaviour, anticipated problems during the placement, and pre-travel preparations...
September 1, 2017: Journal of Travel Medicine
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