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https://www.readbyqxmd.com/read/29786144/self-initiated-use-of-topical-cannabidiol-oil-for-epidermolysis-bullosa
#1
Malcolm P Chelliah, Zachary Zinn, Phoung Khuu, Joyce M C Teng
Epidermolysis bullosa is a rare blistering skin disorder that is challenging to manage because skin fragility and repeated wound healing cause itching, pain, limited mobility, and recurrent infections. Cannabidiol, an active cannabinoid found in cannabis, is postulated to have antiinflammatory and analgesic effects. We report 3 cases of self-initiated topical cannabidiol use in patients with epidermolysis bullosa in an observational study. One patient was weaned completely off oral opioid analgesics. All 3 reported faster wound healing, less blistering, and amelioration of pain with cannabidiol use...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29785752/skin-lesions-over-the-pocket-area-that-may-mimic-cardiac-implantable-electronic-device-infection-a-case-series
#2
Panagiotis Korantzopoulos, Sofia Plakoutsi, Elizabeth Florou, Aris Bechlioulis
BACKGROUND: The early and correct diagnosis of cardiac implantable electronic device (CIED) infections is critical given that early aggressive treatment with complete removal of the system along with antimicrobial therapy dramatically improves outcomes. Pocket infection manifested by local signs of inflammation is the most common form of CIED infections. Conditions mimicking pocket infection have been described in the literature. These include various types of malignancy and rarely allergic reactions/contact dermatitis to pacemaker compounds...
May 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29785327/ex-vivo-confocal-microscopy-an-emerging-technique-in-dermatology
#3
Elisa Cinotti, Jean Luc Perrot, Bruno Labeille, Frédéric Cambazard, Pietro Rubegni
This review aims to give an overview of the current available applications of ex vivo confocal microscopy (EVCM) in dermatology. EVCM is a relatively new imaging technique that allows microscopic examination of freshly excised unfixed tissue. It enables a rapid examination of the skin sample directly in the surgery room and thus represents an alternative to the intraoperative micrographic control of the surgical margins of cutaneous tumors by standard microscopic examination on cryopreserved sections during Mohs surgery...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29785238/intralesional-injection-of-triamcinolone-acetonide-for-subcutaneous-lipoma-causing-musculoskeletal-and-neurologic-symptoms
#4
William A Hayward, Wilmer L Sibbitt, Randy R Sibbitt, Maheswari Muruganandam, Noelle A Rolle, Monthida Fangtham, N Suzanne Emil, Scarlett K Kettwich
Objective: Benign subcutaneous lipomas can cause musculoskeletal pain and nerve impingement. We hypothesized that the potent lipolytic and atrophic effect of 40mg/mL triamcinolone acetonide would atrophy symptomatic lipomas so surgical excision could be avoided. Design: This was a cohort study. Setting: This study took place in an ultrasound injection clinic. Participants: Eight subjects with painful symptomatic lipoma were included. Measurements: Preprocedurally, the margins of the lipomas were palpated and marked with ink, then measured in centimeters (cm)...
May 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29785086/the-utilization-of-an-ocular-wound-chamber-on-corneal-epithelial-wounds
#5
Jennifer S McDaniel, Andrew W Holt, Elaine D Por, Elof Eriksson, Anthony J Johnson, Gina L Griffith
Purpose: Currently available ocular moisture chambers are not adequate to manage the treatment of periocular burns, corneal injuries, and infection. The purpose of these studies was to demonstrate that a flexible, semi-transparent ocular wound chamber device adapted from technology currently used on dermal wounds is safe for use on corneal epithelial injuries. Materials and methods: A depilatory cream (Nair™, 30 seconds) was utilized to remove the excess hair surrounding the left eyes of anesthetized Institute Armand Frappier (IAF) hairless, female guinea pigs (Crl:HA-Hrhr)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29783722/the-occurrence-of-a-commercial-n-pro-and-e-rns-double-mutant-bvdv-1-live-vaccine-strain-in-newborn-calves
#6
Kerstin Wernike, Anna Michelitsch, Andrea Aebischer, Uwe Schaarschmidt, Andrea Konrath, Hermann Nieper, Julia Sehl, Jens P Teifke, Martin Beer
The major source for the spread of bovine viral diarrhea virus (BVDV) are in-utero infected, immunotolerant, persistently infected (PI) animals since they shed enormous amounts of viruses throughout their lives. During the sequence-based virus typing of diagnostic ear notch samples performed in the context of the obligatory German BVDV eradication program, the commercial Npro and Erns double mutant BVDV-1 live-vaccine strain KE-9 was detected in seven newborn calves; their mothers were immunized in the first trimester of gestation...
May 19, 2018: Viruses
https://www.readbyqxmd.com/read/29783681/encapsulation-and-characterization-of-gentamicin-sulfate-in-the-collagen-added-electrospun-nanofibers-for-skin-regeneration
#7
Wan Khartini Wan Abdul Khodir, Abdul Hakim Abdul Razak, Min Hwei Ng, Vincenzo Guarino, Deny Susanti
In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment...
May 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29783024/a-pooled-analysis-of-the-phase-3-revive-trials-randomized-double-blind-studies-to-evaluate-the-safety-and-efficacy-of-iclaprim-versus-vancomycin-for-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#8
David B Huang, G Ralph Corey, Thomas L Holland, Thomas Lodise, William O'Riordan, Mark H Wilcox, Thomas M File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres
BACKGROUND: Iclaprim, a diaminopyrimidine antibiotic, was compared with vancomycin for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs) in two studies (REVIVE-1 and REVIVE-2). OBJECTIVES: We explored the efficacy and tolerability of iclaprim in a pooled analysis of results from both studies. METHODS: REVIVE-1 and REVIVE-2 were Phase 3, double-blind, randomized (1:1), multicenter, active-controlled, non-inferiority (margin of 10%) trials, each designed to enroll 600 patients a piece with ABSSSI...
May 18, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29782954/comparison-between-disk-diffusion-and-agar-dilution-methods-to-determine-in-vitro-susceptibility-of-corynebacterium-spp-clinical-isolates-and-update-of-their-susceptibility
#9
Claudia Barberis, Eugenia Sandoval, Carlos Hernán Rodriguez, María Soledad Ramírez, Angela Famiglietti, Marisa Almuzara, Carlos Vay
INTRODUCTION: Although Corynebacterium species are part of the skin and mucous membranes microbiota, human infections caused by Corynebacterium spp. have been reported and the multidrug resistance pattern of the recovered isolates was emphasized. Due to the usefulness of disk diffusion in daily practice, the purpose of this work was to compare disk diffusion against agar dilution to determine disk diffusion breakpoints and to review the antimicrobial susceptibility of the most frequent Corynebacterium spp...
May 18, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29782820/onchocerciasis-prevalence-human-migration-and-risks-for-onchocerciasis-elimination-in-the-upper-mouhoun-nakamb%C3%A3-and-nazinon-river-basins-in-burkina-faso
#10
Achille S Nikièma, Lassane Koala, Rory J Post, Alain B Paré, Claude Montant Kafando, François Drabo, Adrien M G Belem, Roch K Dabiré, Soungalo Traoré
Historically, the whole of Burkina Faso was considered to be endemic for onchocerciasis (except a small area in the far north of the country) with prevalence rates 60-80%, but all endemic areas were included in the World Health Organisation Onchocerciasis Control Programme, which operated a system of vector control by larviciding beginning in 1974. In Burkina Faso larviciding had been phased out by 1989 when it was considered that onchocerciasis had been reduced to levels below the transmission breakpoint (and any residual infections would disappear without further intervention)...
May 18, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29782522/molecular-detection-of-mycobacterium-ulcerans-in-the-environment-and-its-relationship-with-buruli-ulcer-occurrence-in-zio-and-yoto-districts-of-maritime-region-in-togo
#11
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Marcus Beissner, Kossi Badziklou, Ekanao Tedihou, Edith Nyaku, Komi Amekuse, Franz Xaver Wiedemann, Damintoti Simplice Karou, Gisela Bretzel
BACKGROUND: Buruli Ulcer (BU) is a neglected tropical skin infection caused by Mycobacterium ulcerans. Residence near aquatic areas has been identified as an important source of transmission of M. ulcerans with increased risk of contracting Buruli ulcer. However, the reservoir and the mode of transmission are not yet well known. The aim of this study was to identify the presence of M. ulcerans in the environment and its relationship with Buruli ulcer occurrence in Zio and Yoto districts of the maritime region in south Togo...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782308/activation-of-herpes-simplex-infection-after-tattoo
#12
Antigona Begolli Gerqari, Mybera Ferizi, Merita Kotori, Aferdita Daka, Syzana Hapciu, Ilir Begolli, Mirije Begolli, Idriz Gerqari
Tattooing is a procedure where ink is applied to an area of the skin, mostly intraepidermally (1). This procedure is carried out mainly for aesthetic purposes. Lately, it has been used as a corrective medical procedure following amputation of mammilla. The procedure is aggressive (2), and the fact that skin is punctured many times with the same needle which cannot be fully sterilized may cause infection of the treated area with bacterial, fungal, or viral agents that may lead to health consequences manifesting in the form of verrucae vulgaris, molluscum contagiosum, and herpes simplex...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#13
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#14
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#15
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782301/lymphangioma-circumscriptum-post-radiotherapy-for-penile-cancer-treated-with-co%C3%A2-laser
#16
Dietmar Schulz, Andreas Lein, Ancuta Proca Nicula, Katrin Schierle, Caius Solovan
Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. Its onset may be congenital or due to secondary causes such as radiotherapy, infections, or surgical procedures. We present the case of a 55-year-old patient with a pathologic history of squamous cell carcinoma of the penis followed by radical penectomy. Due to metastasis to the locoregional lymph nodes, the entire affected area was subsequently treated with radiation therapy, receiving a total dose of 55...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781861/clinico-pathological-study-of-4-cases-of-pseudoherpetic-grover-disease-the-same-as-vesicular-grover-disease
#17
Tania M Capusan, María Herrero-Moyano, Javier Fraga, Mar Llamas-Velasco
INTRODUCTION: Grover disease (GD) was described with 4 histopathological patterns, but later wide histopathological studies found additional ones including vesicular GD. From 2014, 2 new patterns, GD with epidermolytic hyperkeratosis and pseudoherpetic GD, have been proposed. OBJECTIVES: The authors present 4 cases of pseudoherpetic GD and review the 6 previously published cases to better characterize this variant clinically and histopathologically. RESULTS: Half of the patients were men...
June 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29781672/immunological-response-to-brucella-abortus-strain-19-vaccination-of-cattle-in-a-communal-area-in-south-africa
#18
Gregory J G Simpson, Tanguy Marcotty, Elodie Rouille, Abel Chilundo, Jean-Jacques Letteson, Jacques Godfroid
Brucellosis is of worldwide economic and public health importance. Heifer vaccination with live attenuated Brucella abortus strain 19 (S19) is the cornerstone of control in low- and middle-income countries. Antibody persistence induced by S19 is directly correlated with the number of colony-forming units (CFU) per dose. There are two vaccination methods: a 'high' dose (5-8 × 1010 CFU) subcutaneously injected or one or two 'low' doses (5 × 109 CFU) through the conjunctival route. This study aimed to evaluate serological reactions to the 'high' dose and possible implications of the serological findings on disease control...
March 29, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29781542/diversity-of-staphylococcus-pseudintermedius-in-carriage-sites-and-skin-lesions-of-dogs-with-superficial-bacterial-folliculitis-potential-implications-for-diagnostic-testing-and-therapy
#19
Rikke Friis Larsen, Lene Boysen, Lisbeth Rem Jessen, Luca Guardabassi, Peter Damborg
BACKGROUND: Staphylococcus pseudintermedius is genotypically diverse within the canine population and multiple strains may colonize individual dogs at any given time. If multiple strains with distinct antimicrobial resistance profiles are present in superficial bacterial folliculitis (SBF), sampling a single skin lesion for culture and antimicrobial susceptibility testing (AST) might be inadequate to select effective therapy. HYPOTHESIS/OBJECTIVES: To investigate S...
May 21, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29781249/prevalence-and-risk-factors-for-injection-site-skin-infections-among-people-who-inject-drugs-pwid-in-tehran
#20
Mehdi Noroozi, Bahram Armoon, Hesam Ghisvand, Alireza Noroozi, Mahmood Karimy, Mohammad Rafi Bazrafshan, Brandon D L Marshall, Bahman Dieji
BACKGROUND/OBJECTIVES: Injection drug use is one of the major public health problems in Iran. Injection drug use is associated with numerous negative health outcomes, such as blood-borne infections (HIV, HCV) and injection site skin infections (abscesses, cellulitis). The aim of this study was to determine prevalence of injection site skin infections and its associated risk factors among people who inject drugs (PWID) in Tehran, Iran. METHODS: The cross-sectional study was conducted from March to August 2016 in Tehran province...
May 20, 2018: Journal of Cosmetic Dermatology
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