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https://www.readbyqxmd.com/read/28812401/management-of-complicated-skin-and-skin-structure-infections-a-call-for-infectious-disease-specialists
#1
Arne Tärnvik
No abstract text is available yet for this article.
August 16, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28811788/clinical-results-of-femoral-head-fracture-dislocation-treated-according-to-the-pipkin-classification
#2
Xiao Yu, Qing-Jiang Pang, Xian-Jun Chen
OBJECTIVE: To summarize the clinical results of femoral head fracture-dislocation treated according to Pipkin classification. METHODS: Atotal of 19 patients with femoral head fracture-dislocation were retrospectively analyzed from Mar. 2008 to Mar. 2015. According to the classification of Pipkin criteria, there were 4 cases in Type-I, 6 cases in Type-II, 6 cases in Type-IIIand 3 cases in Type-IV. Various procedures were taken according to the different types of the fracture, the time of the fracture, and the age of the patients...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811680/the-antimicrobial-peptide-human-beta-defensin-3-is-induced-by-platelet-released-growth-factors-in-primary-keratinocytes
#3
Andreas Bayer, Justus Lammel, Mersedeh Tohidnezhad, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon wounding. The potent antimicrobial activity of hBD-3 together with its wound closure-promoting activities suggests that hBD-3 may play a crucial role in wound healing...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28811383/interleukin-36-cytokines-may-overcome-microbial-immune-evasion-strategies-that-inhibit-interleukin-1-family-signaling
#4
REVIEW
Liselotte E Jensen
Pathogens deploy immune evasion strategies to successfully establish infections within their hosts. Naturally, the host responds by acquiring mechanisms to counter these strategies. There is increasing evidence that the three interleukin-36 (IL-36) cytokines, IL-36α, IL-36β and IL-36γ, play important roles in host immunity. With a focus on the skin as a target for microbial and viral invasion, the current knowledge of IL-36 functions is reviewed. Furthermore, the hypothesis that the IL-36s have evolved to counteract virulence factors is presented using viruses as an example...
August 15, 2017: Science Signaling
https://www.readbyqxmd.com/read/28811343/comparative-genomics-of-escherichia-coli-isolated-from-skin-and-soft-tissue-and-other-extraintestinal-infections
#5
Amit Ranjan, Sabiha Shaik, Nishant Nandanwar, Arif Hussain, Sumeet K Tiwari, Torsten Semmler, Savita Jadhav, Lothar H Wieler, Munirul Alam, Rita R Colwell, Niyaz Ahmed
Escherichia coli, an intestinal Gram-negative bacterium, has been shown to be associated with a variety of diseases in addition to intestinal infections, such as urinary tract infections (UTIs), meningitis in neonates, septicemia, skin and soft tissue infections (SSTIs), and colisepticemia. Thus, for nonintestinal infections, it is categorized as extraintestinal pathogenic E. coli (ExPEC). It is also an opportunistic pathogen, causing cross infections, notably as an agent of zoonotic diseases. However, comparative genomic data providing functional and genetic coordinates for ExPEC strains associated with these different types of infections have not proven conclusive...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28811226/characterization-and-expression-analysis-of-six-interleukin-17-receptor-genes-in-grouper-epinephelus-coioides-after-cryptocaryon-irritans-infection
#6
Biao Jiang, Yan-Wei Li, Ya-Zhou Hu, Heng-Li Luo, An-Xing Li
Interleukin-17 receptors (IL17Rs) mediate the activation of several downstream signal pathways to induce inflammatory response and contribute to the pathology of many autoimmune diseases. In this study, six IL17Rs (IL17RA1, RA2, RB, RC, RD and RE) were cloned and characterized from Epinephelus coioides, an orange-spotted grouper. Multiple sequence alignment and structural analysis revealed that all members of IL17Rs were low in sequence identity with each other. But their structures were conservative in grouper, which contain signal peptide, extracellular FNIII domain (IL17RA1/RA2/RB) or IL-17_R_N domain (IL17RC/RD/RE), transmembrane domain and SEFIR domain in their intracellular region...
August 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28811110/characterizing-the-diagnosis-and-treatment-of-allergic-contact-dermatitis-to-2-octyl-cyanoacrylate-used-for-skin-closure-in-elective-orthopedic-surgery
#7
Brian P Chalmers, Heath P Melugin, Peter K Sculco, Jennifer J Schoch, Rafael J Sierra, Mark W Pagnano, Michael J Stuart, Michael J Taunton
BACKGROUND: While studies have shown that postoperative wound complications can predispose to deep infection following orthopedic surgery, the best form of skin closure has not been elucidated. Furthermore, the unique risks and benefits of each type of wound closure have not been studied. The goal of this study is to present the diagnosis and treatment of patients with allergic contact dermatitis (ACD) from 2-octyl cyanoacrylate, a skin adhesive commonly used in wound closure. METHODS: Twenty-nine patients with ACD to 2-octyl cyanoacrylate (Prineo, Ethicon, NJ) following elective orthopedic surgeries from 2013 to 2016 were retrospectively reviewed; this occurred in 29 of 6088 units of Prineo used at our institution, for an estimated incidence of 0...
July 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28810602/hepatitis-c-virus-associated-cryoglobulinemia-with-membrano-proliferative-glomerulonephritis-treated-with-prednisolone-and-interferon-a-case-report
#8
Qiao-Yan Guo, Man Wu, Yang-Wei Wang, Guang-Dong Sun
Hepatitis C virus (HCV) is a major cause of liver-associated morbidity and has an increasing prevalence worldwide. Hepatitis C virus infection may lead to chronic hepatitis, cirrhosis and liver failure. However, it is also associated with a wide range of extra-hepatic complications, such as cryoglobulinemia, an immune complex disease associated with cryoglobulin leading to multiple organ damage and, while the major symptom is vasculitis. The present study reported on a-58-year-old woman who was diagnosed with HCV-associated cryoglobulinemia with skin, kidney and blood system damage and biopsy-proven cryoglobulinemia membrano-proliferative glomerulonephritis...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810104/strategies-for-prevention-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-and-decolonization
#9
Ashlesha Kaushik, Cassie Wagner, Hollie Consoer, Archana Chatterjee
Methicillin resistant Staphylococcus aureus (MRSA) invasive infections can be severe in the pediatric population with high morbidity and mortality. MRSA colonization can predispose to recurrent skin and soft tissue infections and invasive MRSA disease and is a frequent challenge faced by clinicians. This article reviews the importance of MRSA as a pathogen, MRSA colonization and various MRSA decolonization strategies.
December 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28809155/microbe-profile-candida-albicans-a-shape-changing-opportunistic-pathogenic-fungus-of-humans
#10
Neil A R Gow, Bhawna Yadav
(a) Morphotypes of Candida albicans (blue sector, vegetative forms; pink sector, forms related to mating or changes in ploidy). Cell types shown include: budding yeast cells; elongated conjoined yeasts forming pseudohyphae; parallel-sided hyphae; chlamydospores formed from suspensor cells; enlarged goliath cells formed under zinc deprivation (unpublished study, image from Duncan Wilson); intestinal gut form cells (image from Suzanne Noble); mating competence defined by white-grey-opaque cell transitions (images from Guanghua Huang); elongated chemotactic shmoo-mating projections leading to tetraploid zygote formation (images from David Soll and Karla Daniels); trimera formed by unequal chromosome segregation under antifungal exposure (image from Judith Berman)...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28809141/hpv-11-variability-persistence-and-progression-to-genital-warts-in-men-the-him-study
#11
Ema Flores-Díaz, Karen A Sereday, Silvaneide Ferreira, Bradley Sirak, João Simão Sobrinho, Maria Luiza Baggio, Lenice Galan, Roberto C Silva, Eduardo Lazcano-Ponce, Anna R Giuliano, Luisa L Villa, Laura Sichero, The Him Study Group
HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases...
August 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28808593/combined-bone-transportation-and-lengthening-techniques-for-the-treatment-of-septic-nonunion-of-the-forearm-followed-by-tendon-transfer
#12
Konstantinos Ditsios, Eirini Iosifidou, Lazaros Kostretzis, Panagiotis Konstantinou, Iosafat Pinto, Ioannis Theodoroudis, Ippokratis Hatzokos
Infected nonunion of a forearm fracture complicated by a considerable skin-muscle defect poses a great challenge to orthopaedic surgeons. The treatment strategy comprises eradication of the infection, ensuring bony union and soft tissue coverage along with functional restoration. We report a case of a 23-year-old man with an open Gustilo-Anderson IIIb fracture complicated by infected nonunion after internal fixation. After thorough surgical debridement, a considerable soft tissue defect, extensor muscle loss, and posterior interosseous nerve laceration had to be addressed...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28808517/the-mythos-of-laudable-pus-along-with-an-explanation-for-its-origin
#13
Jeffrey A Freiberg
The presence of pus is one of the most easily recognizable signs of an infection. However, for several centuries suppuration, known as 'laudable pus,' was believed to be a sign of a healthy, healing wound. This historical misconception can be explained by the difference in the presentation of a necrotizing soft tissue infection versus other more common skin and soft tissue infections. Chronic wound infections, due to pyogenic bacteria, typically produce large amounts of thick, whitish-yellow pus. On the other hand, necrotizing soft tissue infections, despite their severe mortality and morbidity, are devoid of pus in the traditional sense...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28808369/ultrasound-guidance-for-central-venous-catheterization-a-step-further-to-prevent-malposition-of-central-venous-catheter-before-radiographic-confirmation
#14
Devinder Midha, Vipal Chawla, Arun Kumar, Amit Kumar Mandal
Ultrasound (USG) guidance has long been used for guiding central venous catheterization. USG provides direct visualization of needle puncture through the skin into the vein. Most of the time USG guidance is just limited to puncturing of the vein and seeing guidewire entering the vein while malpositioning of catheter occurs after that which is seen later on while checking chest radiograph. Repositioning of catheter after that becomes not only difficult requiring repeated chest radiograph to reconfirm position of catheter but also increases chances of infection with repeated manipulations...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28808209/herpes-zoster-in-breast-cancer-a-case-report
#15
Mohammad Darvishi, Narges Vasei
There is little information on herpes zoster infection in breast cancer patients as a complication during adjuvant chemotherapy. We report a case of herpes zoster in a 65-year-old woman presented with low grade fever and vital signs together with skin symptoms such as severe edema, irritation and itching in the left breast where there was wound drainage. PCR test revealed varicella zoster virus. To the best of our knowledge, the histologic features coupled with PCR led to a diagnosis of herpes zoster.
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807958/management-of-impetigo-and-cellulitis-simple-considerations-for-promoting-appropriate-antibiotic-use-in-skin-infections
#16
Lynette Kosar, Tessa Laubscher
No abstract text is available yet for this article.
August 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28807913/reducing-antibacterial-development-risk-for-gsk1322322-by-exploring-potential-human-dose-regimens-in-nonclinical-efficacy-studies-using-immunocompetent-rats
#17
Jennifer L Hoover, Christine M Singley, Philippa Elefante, Peter DeMarsh, Magdalena Zalacain, Stephen Rittenhouse
Directly testing proposed clinical dosing regimens in nonclinical studies can reduce risk during the development of novel antibacterial agents. Optimal dosing regimens can be identified in animal models by testing recreated human pharmacokinetic profiles. An example of this approach is presented using continuous intravenous infusions of GSK1322322 in immunocompetent rats to evaluate recreated Phase 1 human exposures in pneumonia models with Streptococcus pneumoniae and Haemophilus influenzae and an abscess model with Staphylococcus aureus GSK1322322 was administered via continuous intravenous infusion to recreate 1000 or 1500 mg oral doses every 12h in humans...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28807906/impact-of-type-iii-secretion-effectors-and-of-phenoxyacetamide-inhibitors-of-type-iii-secretion-on-abscess-formation-in-a-mouse-model-of-pseudomonas-aeruginosa-infection
#18
Bryan J Berube, Katherine Murphy, Matthew C Torhan, Nicholas O Bowlin, John D Williams, Terry L Bowlin, Donald T Moir, Alan R Hauser
Pseudomonas aeruginosa is a leading cause of intra-abdominal infections, wound infections, and community-acquired folliculitis, each of which may involve macro- or micro-abscess formation. The rising incidence of multi-drug resistance among P. aeruginosa isolates has increased both the economic burden and the morbidity and mortality associated with P. aeruginosa disease and necessitates a search for novel therapeutics. Previous work from our group detailed novel phenoxyacetamide inhibitors that block type III secretion and injection into host cells in vitro In this study, we used a murine abscess model of P...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28807880/-broad-spectrum-bactericidal-activity-of-a-new-bioactive-grafting-material-f18-against-clinically-important-bacterial-strains
#19
M T Souza, L A Campanini, C R Chinaglia, O Peitl, E D Zanotto, C W O Souza
Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in the current practice of medicine. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical impact. Researchers at the Vitreous Materials Laboratory (LaMaV-UFSCar) recently developed a glass composition, F18, which presents an improved workability range combined with high bioactivity...
August 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28807774/chlorin-e6-mediated-photodynamic-therapy-promotes-collagen-production-and-suppresses-mmps-expression-via-modulating-ap-1-signaling-in-p-acnes-stimulated-hacat-cells
#20
A-Reum Ryu, Mi-Young Lee
BACKGROUND: Photodynamic therapy (PDT) is a clinically approved therapeutics for cancers and non-neoplastic diseases, based on the use of a photosensitizer activated by a light. The feasibility of PDT depends on several factors, such as PDT dose, photosensitizer efficacy, type of light source, and target tissue irradiated. METHODS: In this study, the second generation photosensitizer chlorin e6 (Ce6) and halogen light were used to investigate their PDT effect on the collagen production and MMPs expression of heat killed P...
August 11, 2017: Photodiagnosis and Photodynamic Therapy
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