keyword
MENU ▼
Read by QxMD icon Read
search

staging of glioma

keyword
https://www.readbyqxmd.com/read/29456798/-18-f-radiolabeled-panobinostat-allows-for-positron-emission-tomography-guided-delivery-of-a-histone-deacetylase-inhibitor
#1
Harikrishna Kommidi, Umberto Tosi, Uday B Maachani, Hua Guo, Christopher S Marnell, Benedict Law, Mark M Souweidane, Richard Ting
Histone deacetylase (HDAC) inhibition is becoming an increasingly popular approach to treat cancer, as HDAC overexpression is common in many malignancies. The blood-brain barrier (BBB) prevents systemically delivered drugs from reaching brain at effective concentration, making small-molecule-HDAC inhibition in brain tumors particularly challenging. To circumvent the BBB, novel routes for administering therapeutics are being considered in the clinic, and a need exists for drugs whose deliveries can be directly imaged, so that effective delivery across the BBB can be monitored...
February 8, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29454349/sgef-is-a-potential-prognostic-and-therapeutic-target-for-lung-adenocarcinoma
#2
Qian Chen, Xiao Lu, Quan-Xing Liu, Dong Zhou, Yuan Qiu, Ji-Gang Dai, Hong Zheng
BACKGROUND: SH3-containing guanine nucleotide exchange factor (SGEF), a RhoG-specific guanine nucleotide exchange factor (GEF), was consider as a key signal that determines cancer cell invasion. Although SGEF has been considered to highly express in glioma and prostate cancer. However, it is not well illustrated in LAC. METHODS: In this experiment, expression of SGEF was detected in 92 LAC and corresponding normal tissue samples by immunohistochemistry. In addition, we evaluated the invasion and migration of lung adenocarcinoma cells by the gain and loss of SGEF expression...
February 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29444314/diffuse-astrocytoma-idh-wildtype-a-dissolving-diagnosis
#3
Martin Hasselblatt, Mohammed Jaber, David Reuss, Oliver Grauer, Annkatrin Bibo, Stephanie Terwey, Uta Schick, Heinrich Ebel, Thomas Niederstadt, Walter Stummer, Andreas von Deimling, Werner Paulus
The histological and molecular features and even the mere existence of diffuse astrocytoma, IDH-wildtype, remain unclear. We therefore examined 212 diffuse astrocytomas (grade II WHO) in adults using IDH1(R132H) immunohistochemistry followed by IDH1/IDH2 sequencing and neuroimaging review. DNA methylation status and copy number profiles were assessed by Infinium HumanMethylation450k BeadChip. Only 25/212 patients harbored tumors without IDH1/IDH2 hotspot mutations and without contrast enhancement. By DNA methylation profiling, 10/25 tumors were classified as glioblastoma, IDH-wildtype, and an additional 7 cases could not be classified using methylome analysis, but showed genetic characteristics of glioblastoma...
February 9, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29438779/down-regulation-of-mirna-320c-promotes-tumor-growth-and-metastasis-and-predicts-poor-prognosis-in-human-glioma
#4
Qiao-Li Lv, Hui-Ting Zhu, Xiao-Hua Cheng, Hong-Mi Li, Hong-Hao Zhou, Shu-Hui Chen
Emerging studies show that dysregulated miRNAs are implicated in tumorigenesis and progression of various cancers. MiRNA-320c, an important member of miRNA-320 family, was characterized as a new candidate miRNA that suppressed the development of colorectal cancer and bladder cancer. However, the function of miRNA-320c in human glioma remained unclear. Here, we found that miRNA-320c was significantly down-regulated in glioma tissues and cell lines in contrast with normal brain tissues, being tightly related to clinical stage of glioma by qRT-PCR...
February 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29427894/clinical-characteristics-associated-with-the-intracranial-dissemination-of-gliomas
#5
Xu Cai, Jun-Jie Qin, Shu-Yu Hao, Huan Li, Chun Zeng, Sheng-Jun Sun, Lan-Bing Yu, Zhi-Xian Gao, Jian Xie
OBJECTIVES: Glioma is the most common malignant tumor of the brain and the intracranial dissemination of gliomas is the late stage of the development of the tumor. However, there is little research in literature on the occurrence of intracranial dissemination of gliomas. In order to provide a reference for clinical work, we carried out this study on intracranial dissemination of glioma. PATIENTS AND METHODS: A total of 629 patients with gliomas received tumor resection by the same surgeon from August 2010 to September 2015 were included in this study...
February 1, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29417580/in-vivo-characterization-of-brain-metabolism-by-1-h-mrs-13-c-mrs-and-18-fdg-pet-reveals-significant-glucose-oxidation-of-invasively-growing-glioma-cells
#6
Marta Lai, Irene Vassallo, Bernard Lanz, Carole Poitry-Yamate, Marie-France Hamou, Cristina Cudalbu, Rolf Gruetter, Monika E Hegi
Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of invasively growing glioma xenografts in the mouse brain. Animals were subjected longitudinally to Magnetic Resonance Imaging (MRI) and 1 H spectroscopy (MRS) at ultra high field (14.1 Tesla) that allowed the measurement of 16 metabolic biomarkers to characterize the metabolic profiles...
February 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29412496/characterization-of-active-and-infiltrative-tumorous-subregions-from-normal-tissue-in-brain-gliomas-using-multiparametric-mri
#7
Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh-Ardalan, Alejandro F Frangi, Christos Davatzikos, Hamidreza Saligheh Rad
BACKGROUND: Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity. PURPOSE: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. STUDY TYPE: Prospective. POPULATION: Fifty-one tissue specimens were collected using image-guided localized biopsy surgery from 10 patients with newly diagnosed gliomas...
February 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29409010/reactive-species-balance-via-gtp-cyclohydrolase-i-regulates-glioblastoma-growth-and-tumor-initiating-cell-maintenance
#8
Anh Nhat Tran, Kiera Walker, David G Harrison, Wei Chen, James Mobley, Lauren Hocevar, James R Hackney, Randee S Sedaka, Jennifer S Pollock, Matthew S Goldberg, Dolores Hambardzumyan, Sara J Cooper, Yancey Gillespie, Anita B Hjelmeland
Background: Depending on the level, differentiation state, and tumor stage, reactive nitrogen and oxygen species inhibit or increase cancer growth and tumor initiating cell maintenance. The rate limiting enzyme in a pathway that can regulate reactive species production but has not been thoroughly investigated in glioblastoma (GBM; grade IV astrocytoma) is GTP cyclohydrolase 1 (GCH1). We sought to define the role of GCH1 in the regulation of GBM growth and brain tumor initiating cell maintenance...
February 2, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29408716/scanning-fiber-endoscope-improves-detection-of-5-ala-induced-protoporphyrin-ix-fluorescence-at-the-boundary-of-infiltrative-glioma
#9
Evgenii Belykh, Eric J Miller, Danying Hu, Nikolay L Martirosyan, Eric C Woolf, Adrienne C Scheck, Vadim A Byvaltsev, Peter Nakaji, Leonard Y Nelson, Eric J Seibel, Mark C Preul
OBJECTIVE: Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas. Current wide-field imaging technologies do not have sufficient sensitivity to detect low PpIX concentrations. We evaluated a scanning fiber endoscope (SFE) for detection of PpIX fluorescence in gliomas and compared it with an operating microscope (OPMI) equipped with fluorescence module and a benchtop confocal laser scanning microscope (CLSM)...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29401154/bereaved-caregivers-to-patients-with-high-grade-glioma-a-qualitative-explorative-study
#10
Karin Piil, Mary Jarden
PURPOSE: The disease and treatment trajectory of patients with high-grade glioma is a burdensome period for the patients' closest relatives who become informal caregivers. Caregivers experiencing this demanding shift in role are at risk of developing symptoms such as depression. Few studies have explored the needs and experiences of bereaved caregivers, and there is lack of evidence-based practice. This study explores the perspectives of newly bereaved caregivers to patients with high-grade glioma on end-of-life caregiving and bereavement...
February 2, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29394005/radiomics-strategy-for-molecular-subtype-stratification-of-lower-grade-glioma-detecting-idh-and-tp53-mutations-based-on-multimodal-mri
#11
Xi Zhang, Qiang Tian, Liang Wang, Yang Liu, Baojuan Li, Zhengrong Liang, Peng Gao, Kaizhong Zheng, Bofeng Zhao, Hongbing Lu
BACKGROUND: Noninvasive detection of isocitrate dehydrogenase (IDH) and TP53 mutations are meaningful for molecular stratification of lower-grade gliomas (LrGG). PURPOSE: To explore potential MRI features reflecting IDH and TP53 mutations of LrGG, and propose a radiomics strategy for detecting them. STUDY TYPE: Retrospective, radiomics. POPULATION/SUBJECTS: A total of 103 LrGG patients were separated into development (n = 73) and validation (n = 30) cohorts...
February 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29392777/p53-and-nf-1-loss-plays-distinct-but-complementary-roles-in-glioma-initiation-and-progression
#12
Phillippe P Gonzalez, Jungeun Kim, Rui Pedro Galvao, Nichola Cruickshanks, Roger Abounader, Hui Zong
Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have identified oligodendrocyte precursor cell (OPC) as the cell of origin for glioma following the concurrent deletion of p53 and NF1 using a mouse genetic mosaic system that can reveal mutant cells prior to malignancy. In the current study, we set out to deconstruct the gliomagenic process in two aspects...
February 2, 2018: Glia
https://www.readbyqxmd.com/read/29384395/diffuse-low-grade-glioma-mimicking-ischemic-infarct-a-case-report
#13
Gaigai Li, Yanyan Li, Yang Hu, Qian Wu, Haihan Yu, Hong Deng, Zhouping Tang
Diffuse low-grade gliomas (LGGs) include WHO grade II diffuse astrocytoma, oligodendroglioma, and oligoastrocytoma. Since the neurological symptoms of LGGs are often subtle and deceptive, LGGs are easily overlooked at their early stage. Here, we report a case of a 49-year-old female with symptoms and imaging manifestations mimicking ischemic infarct. After treatments for ischemic stroke, the symptoms initially fluctuating and then aggravated. In addition, we found that the locations of the lesions did not match the vascular distribution and no obvious abnormalities were observed by Computed Tomography Angiography (CTA) and Transcranial Doppler (TCD)...
January 31, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29344634/underlying-mechanism-of-the-photodynamic-activity-of-hematoporphyrin%C3%A2-induced-apoptosis-in-u87-glioma-cells
#14
Shi-Xiang Yuan, Jun-Liang Li, Xin-Ke Xu, Wei Chen, Cheng Chen, Kun-Qi Kuang, Fang-Yu Wang, Kai Wang, Fang-Cheng Li
Photodynamic therapy (PDT) is a relatively novel type of tumor therapy method with low toxicity and limited side‑effects. The aim of the present study was to investigate the underlying mechanism and potential microRNAs (miRNAs) involved in the treatment of glioma by PDT with hematoporphyrin, a clinical photosensitizer. The photodynamic activity of hematoporphyrin on the cell viability and apoptosis of gliomas was investigated by MTT, and flow cytometry and fluorescence microscopy, respectively. Alterations in singlet oxygen and mitochondrial membrane potential were detected...
January 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29330750/immunologic-and-gene-expression-profiles-of-spontaneous-canine-oligodendrogliomas
#15
Anna Filley, Mario Henriquez, Tanmoy Bhowmik, Brij Nath Tewari, Xi Rao, Jun Wan, Margaret A Miller, Yunlong Liu, R Timothy Bentley, Mahua Dey
Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introduction of an additional preclinical animal model better approximating the complexity of human MG, particularly in interactions with host immune responses, will bridge the existing gap between these two stages of testing...
January 12, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29330292/microenvironmental-derived-regulation-of-hif-signaling-drives-transcriptional-heterogeneity-in-glioblastoma-multiforme
#16
Dieter Henrik Heiland, Annette Gaebelein, Melanie Boerries, Jakob Woerner, Nils Pompe, Pamela Franco, Sabrina Heynckes, Mark D Bartholomä, Darren Ó hAilín, Maria Stella Carro, Marco Prinz, Stefan Weber, Irina Mader, Daniel Delev, Oliver Schnell
The evolving and highly heterogeneous nature of malignant brain tumors underlies their limited response to therapy and poor prognosis. In addition to genetic alterations, highly dynamic processes such as transcriptional and metabolic reprogramming play an important role in the development of tumor heterogeneity. The present study reports an adaptive mechanism in which the metabolic environment of malignant glioma drives transcriptional reprogramming. Multi-regional analysis of a glioblastoma patient biopsy revealed a metabolic landscape marked by varying stages of hypoxia and creatine enrichment...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29314345/differentiation-between-vasogenic-edema-and-infiltrative-tumor-in-patients-with-high-grade-gliomas-using-texture-patch-based-analysis
#17
Moran Artzi, Gilad Liberman, Deborah T Blumenthal, Orna Aizenstein, Felix Bokstein, Dafna Ben Bashat
BACKGROUND: High-grade gliomas (HGGs) induce both vasogenic edema and extensive infiltration of tumor cells, both of which present with similar appearance on conventional MRI. Using current radiological criteria, differentiation between these tumoral and nontumoral areas within the nonenhancing lesion area remains challenging. PURPOSE: To use radiomics patch-based analysis, based on conventional MRI, for the classification of the nonenhancing lesion area in patients with HGG into tumoral and nontumoral components...
January 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29295693/novel-homeodomain-transcription-factor-nkx2-2-in-the-brain-tumor-development
#18
Mubeena Pm Mariyath, Mehdi Hayat Shahi, Shirin Farheen, Mohd Tayyab, Nabeela Khanam, Asif Ali
BACKGROUND: Complex central nervous system (CNS) is made of neuronal cells and glial cells. Cells of central nervous system are able to regenerate after injury and during repairing. Sonic hedgehog pathway initiated by Shh-N a glycoprotein plays vital role in CNS patterning growth, development and now tumorigenesis. Nkx2.2 homeodomain transcription factor is an effecter molecule, which is positively regulated by Shh during normal growth. Nkx2.2 is essential for V3 domain specification during neural tube patterning at embryonic stage...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29245920/nampt-overexpression-induces-cancer-stemness-and-defines-a-novel-tumor-signature-for-glioma-prognosis
#19
Antonio Lucena-Cacace, Daniel Otero-Albiol, Manuel P Jiménez-García, Javier Peinado-Serrano, Amancio Carnero
Gliomas are the most prevalent primary malignant brain tumors associated with poor prognosis. NAMPT, a rate-limiting enzyme that boosts the nicotinamide adenine dinucleotide (NAD) regeneration in the salvage pathway, is commonly expressed in these tumors. NAD metabolism is required to maintain tissue homeostasis. To maintain metabolism, cancer cells require a stable NAD regeneration circuit. However, high levels of NAD confer resistance to therapy to these tumors, usually treated with Temozolomide (TMZ). We report that NAMPT overexpression in glioma cell lines increases tumorigenic properties controlling stem cell pathways and enriching the cancer-initiating cell (CIC) population...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209782/advances-in-immunotherapeutic-research-for-glioma-therapy
#20
REVIEW
Jeremy Tetsuo Miyauchi, Stella E Tsirka
Gliomas are primary malignancies of the brain. Tumors are staged based on malignancy, nuclear atypia, and infiltration of the surrounding brain parenchyma. Tumors are often diagnosed once patients become symptomatic, at which time the lesion is sizable. Glioblastoma (grade IV glioma) is highly aggressive and difficult to treat. Most tumors are diagnosed de novo. The gold standard of therapy, implemented over a decade ago, consists of fractionated radiotherapy and temozolomide, but unfortunately, chemotherapeutic resistance arises...
December 5, 2017: Journal of Neurology
keyword
keyword
49617
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"