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https://www.readbyqxmd.com/read/29928399/microrna-423-3p-promotes-glioma-growth-by-targeting-panx2
#1
Jing Xu, Jian He, He Huang, Renjun Peng, Jian Xi
Previously, a number of microRNAs (miRs) have been identified to participate in the development and progression of glioma via the regulation of their target genes. However, the molecular mechanisms underlying the effect of miR-423-3p in glioma growth remain unclear. In the present study, the reverse transcription-quantitative polymerase chain reaction and western blotting were used to assess the mRNA and protein expression levels of miR-423-3p, respectively. An MTT assay and flow cytometry were performed to determine cell proliferation and apoptosis, respectively...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29917115/study-protocol-for-a-randomized-controlled-trial-evaluating-the-efficacy-of-an-evidence-based-ipad-app-for-cognitive-rehabilitation-in-patients-with-primary-brain-tumors
#2
Sophie Dorothee van der Linden, Margriet Maria Sitskoorn, Geert-Jan Maria Rutten, Karin Gehring
BACKGROUND: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started. OBJECTIVE: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease...
June 16, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29914561/boron-delivery-agents-for-neutron-capture-therapy-of-cancer
#3
REVIEW
Rolf F Barth, Peng Mi, Weilian Yang
Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system. Two low molecular weight boron-containing drugs currently are being used clinically, boronophenylalanine (BPA) and sodium borocaptate (BSH). Although they are far from being ideal, their therapeutic efficacy has been demonstrated in patients with high grade gliomas, recurrent tumors of the head and neck region, and a much smaller number with cutaneous and extra-cutaneous melanomas...
June 19, 2018: Cancer communications
https://www.readbyqxmd.com/read/29910638/prognostic-value-and-clinical-significance-of-long-noncoding-rna-casc2-in-human-malignancies-a-meta-analysis
#4
Juan Cai, Xueliang Zuo, Zhiqiang Chen, Wenying Zhao, Yiping Zhu, Zhengxiang Zhang, Xiaobing Ye
Purpose: This meta-analysis aimed to assess the prognostic value of long noncoding RNA cancer susceptibility candidate 2 (CASC2) in human tumors. Materials and methods: We searched the available databases up to December 2017. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to examine the prognostic impact of CASC2 on overall survival (OS) in patients diagnosed with malignancies. Results: A total of eight studies with 663 cancer patients were enrolled...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29908894/microrna-499a-decelerates-glioma-cell-proliferation-while-accelerating-apoptosis-through-the-suppression-of-notch1-and-the-mapk-signaling-pathway
#5
Bang-Qing Wang, Bin Yang, Hua-Chao Yang, Jun-Yi Wang, Sen Hu, Yu-Shuai Gao, Xing-Yao Bu
As the most common and lethal of intracranial tumors, glioma accounts for 81% of all malignant brain tumors. Research data has identified the role of microRNAs (miRs) as functional suppressers in the progression of Glioma. The present study aimed to, ascertain as to whether microRNA-499a (miR-499a) influences cell proliferation and apoptosis through the MAPK signaling pathway by targeting Notch1 in glioma. Both glioma and adjacent tissues between 2012~2016, were obtained from People's Hospital of Zhengzhou University (Henan Provincial People's Hospital)...
June 14, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29906746/linc-pou3f3-is-overexpressed-in-hepatocellular-carcinoma-and-regulates-cell-proliferation-migration-and-invasion
#6
Yichun Li, Yannan Li, Dan Wang, Qingdong Meng
Linc-POU3F3 showed an up-regulated tendency and functioned as tumor promoter in glioma, esophageal cancer and colorectal cancer. There was no report about the expression pattern and clinical value of linc-POU3F3 in hepatocellular carcinoma. Thus, the purpose of our study is to explore the clinical significance and biological role of linc-POU3F3 in hepatocellular carcinoma. Our results suggested that levels of linc-POU3F3 were dramatically increased in hepatocellular carcinoma tissues and cell lines compared with paired normal hepatic tissues and normal hepatic cell line, respectively...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29890731/wip-yap-taz-as-a-new-pro-oncogenic-pathway-in-glioma
#7
Sergio Rivas, Inés M Antón, Francisco Wandosell
Wild-type p53 (wtp53) is described as a tumour suppressor gene, and mutations in p53 occur in many human cancers. Indeed, in high-grade malignant glioma, numerous molecular genetics studies have established central roles of RTK-PI3K-PTEN and ARF-MDM2-p53 INK4a-RB pathways in promoting oncogenic capacity. Deregulation of these signalling pathways, among others, drives changes in the glial/stem cell state and environment that permit autonomous growth. The initially transformed cell may undergo subsequent modifications, acquiring a more complete tumour-initiating phenotype responsible for disease advancement to stages that are more aggressive...
June 9, 2018: Cancers
https://www.readbyqxmd.com/read/29886303/hammock-middle-cerebral-artery-and-delayed-infarction-in-the-lenticulostriate-artery-after-a-staged-resection-of-giant-insular-glioma-a-case-report
#8
Seiichiro Hirono, Kou Ozaki, Daisuke Ito, Tomoo Matsutani, Yasuo Iwadate
BACKGROUND: Delayed infarction in the lenticulostriate artery (LSA) area after insular glioma resection are not common and its pathophysiology remains unknown. CASE DESCRIPTION: A 32-year-old right-handed man with a giant insular low-grade glioma with frontal and temporal extension underwent awake craniotomy with an intentional staged surgery strategy. Preoperative radiological images demonstrated a diagonally elevated middle cerebral artery (MCA) by the temporal tumor and the a significantly compressed striatum...
June 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29885857/from-epidemiology-to-treatment-aspirin-s-prevention-of-brain-and-breast-cancer-and-cardioprotection-may-associate-with-its-metabolite-gentisic-acid
#9
Meric A Altinoz, Ilhan Elmaci, Salih Cengiz, Ebru Emekli-Alturfan, Aysel Ozpinar
BACKGROUND: Epidemiological studies indicate that aspirin consumption reduces the risk of tumors, which is especially relevant for colonic adenoma and carcinoma. Similar observations were made for glial brain tumors and breast cancers, yet the results are inconsistent. Gentisic acid (GA) is a minor catabolite of aspirin; yet humans carrying CYP2C9-variants incapable to catabolize aspirin to GA do not benefit from aspirin in prevention against colonic adenoma. GA blocks binding of Fibroblastic Growth Factor to its receptor and its sulphonate metabolite dobesilic acid blocks growth of C6 glioblastoma in vivo...
June 7, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29870846/patient-specific-actual-size-3d-printed-models-for-patient-education-in-glioma-treatment-first-experiences
#10
Tom H van de Belt, Hugo Nijmeijer, David Grim, Lucien Jlpg Engelen, Rinaldo Vreeken, Marleen Mmj van Gelder, Mark Ter Laan
BACKGROUND: Cancer patients need high quality information about the disease stage, treatment options and side effects. High quality information can also improve health literacy, shared decision-making and satisfaction. We created patient-specific 3D models of tumours including surrounding functional areas, and assessed what patients with glioma actually value (or fear) about these models when they are used to educate them about the relation between their tumour and specific brain parts, the surgical procedure, and risks...
June 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29867200/decreased-expression-of-arhgap15-promotes-the-development-of-colorectal-cancer-through-pten-akt-foxo1-axis
#11
Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru, Xianju Qin
Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho GTPase-activating protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed in glioma and pancreatic ductal adenocarcinoma. The present study explored the expression in colorectal cancer (CRC) by quantitative real-time PCR and immunohistochemistry analysis. The possible function of ARHGAP15 in CRC was investegated in vitro and in vivo. We found that ARHGAP15 expression was obviously lower in CRC specimens than in normal colonic mucosa...
June 4, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29864920/forkhead-box-d1-promotes-proliferation-and-suppresses-apoptosis-via-regulating-polo-like-kinase-2-in-colorectal-cancer
#12
Tao Han, Jie Lin, Yannan Wang, Qihao Fan, Haojie Sun, Youmao Tao, Caixia Sun
Transcription factor forkhead box D1 (FOXD1), a member of forkhead box family, has been recognized as a caner-related gene. Aberrant expression of FOXD1 is observed in glioma, lung cancer and breast cancer. However, the clinical significance of FOXD1 and its role in colorectal cancer (CRC) are unknown. Here, we found that FOXD1 displayed a higher expression in CRC tissues compared to tumor-adjacent tissues. Upregulation of FOXD1 was further confirmed in CRC tissues compared to normal tissues based on data from three GSE cohorts...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29863243/decreased-expression-of-mir-1254-is-associated-with-cancer-aggressiveness-and-predicts-poor-outcome-in-cervical-cancer
#13
J Zhou, X Liu, C-H Wang, D Wang, J-J Du
OBJECTIVE: MiR-1254 has been demonstrated to play a critical role in the progression of several types of cancer, but its role in cervical cancer remains largely unclear. The aim of the present study was to examine the expression pattern of miR-1254, and its clinical significance in cervical cancer. PATIENTS AND METHODS: RT-PCR was performed to evaluate miR-1254 levels in 181 pairs of cervical cancer specimens and adjacent noncancerous tissues. The correlation between the miR-1254 levels and the clinicopathological factors of the glioma patients was analyzed...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29846705/idh-mutation-status-is-associated-with-distinct-vascular-gene-expression-signatures-in-lower-grade-gliomas
#14
Lei Zhang, Liqun He, Roberta Lugano, Kenney Roodakker, Michael Bergquist, Anja Smits, Anna Dimberg
Background: Vascular gene expression patterns in lower grade gliomas (LGG, diffuse WHO grade II-III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH)-mutation status affects vascular phenotype. Methods: Gene expression was analyzed using an in-house dataset derived from microdissected vessels and total tumor samples from human glioma in combination with expression data from 289 LGG samples available in the TCGA database...
May 29, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29798515/-advances-in-the-research-of-the-relationship-between-mirna-29c-and-cancer
#15
REVIEW
R H Fang, X B Ji
miRNAs are a class of endogenous non coding, single stranded small RNAs, which regulate the expression of tumor suppressor genes and oncogenes and involve in almost all of the tumor-related processes. miRNA-29c, acting as a tumor suppressor of miRNA, has low expression in many solid malignancies such as nasopharyngeal carcinoma, glioma, gastric cancer, hepatocellular carcinoma, bladder cancer, esophageal cancer, breast cancer, colon cancer and so on. It relates with cancerous proliferation, apoptosis, invasion and metastasis...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29784746/role-of-molecular-pathology-in-the-treatment-of-anaplastic-gliomas-and-glioblastomas
#16
Matthias Holdhoff
The 2016 WHO Classification of Tumors of the Central Nervous System integrated molecular biomarkers into the classifications of malignant gliomas. Several markers now play a key role in our understanding of these tumors and are integral for clinical decision-making; these include codeletion of 1p and 19q and IDH1 and IDH2 mutations. The presentation by Matthias Holdhoff, MD, PhD, at the NCCN 23rd Annual Conference discussed the current understanding of anaplastic gliomas (WHO grade III) in the context of the new classification and its implications on clinical practice...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29774498/microrna-1231-exerts-a-tumor-suppressor-role-through-regulating-the-egfr-pi3k-akt-axis-in-glioma
#17
Jiale Zhang, Jie Zhang, Wenjin Qiu, Jian Zhang, Yangyang Li, Enjun Kong, Ailin Lu, Jia Xu, Xiaoming Lu
PURPOSE: MicroRNAs (miRNAs) have been shown to be involved in the initiation and progression of glioma. However, the underlying molecular mechanisms are still unclear. METHODS: We performed microarray analysis to evaluate miRNA expression levels in 158 glioma tissue samples, and examined miR-1231 levels in glioma samples and healthy brain tissues using qRT-PCR. In vitro analyses were performed using miR-1231 mimics, inhibitors, and siRNA targeting EGFR. We used flow cytometry, CCK-8 assays, and colony formation assays to examine glioma proliferation and cell cycle analysis...
May 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29747666/survival-of-rats-bearing-advanced-intracerebral-f-98-tumors-after-glutathione-depletion-and-microbeam-radiation-therapy-conclusions-from-a-pilot-project
#18
E Schültke, E Bräuer-Krisch, H Blattmann, H Requardt, J A Laissue, G Hildebrandt
BACKGROUND: Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administration of the glutathione synthesis inhibitor Buthionine-SR-Sulfoximine (BSO) should increase survival time. METHODS: BSO was tested in combination with an experimental synchrotron-based treatment, microbeam radiation therapy (MRT), characterized by spatially and periodically alternating microscopic dose distribution...
May 10, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29741745/prospective-feasibility-and-safety-assessment-of-surgical-biopsy-for-patients-with-newly-diagnosed-diffuse-intrinsic-pontine-glioma
#19
Nalin Gupta, Liliana C Goumnerova, Peter Manley, Susan N Chi, Donna Neuberg, Maneka Puligandla, Jason Fangusaro, Stewart Goldman, Tadanori Tomita, Tord Alden, Arthur DiPatri, Joshua B Rubin, Karen Gauvain, David Limbrick, Jeffrey Leonard, J Russel Geyer, Sarah Leary, Samuel Browd, Zhihong Wang, Sandeep Sood, Anne Bendel, Mahmoud Nagib, Sharon Gardner, Matthias A Karajannis, David Harter, Kanyalakshmi Ayyanar, William Gump, Daniel C Bowers, Bradley Weprin, Tobey J MacDonald, Dolly Aguilera, Barunashish Brahma, Nathan J Robison, Erin Kiehna, Mark Krieger, Eric Sandler, Philipp Aldana, Ziad Khatib, John Ragheb, Sanjiv Bhatia, Sabine Mueller, Anu Banerjee, Amy-Lee Bredlau, Sri Gururangan, Herbert Fuchs, Kenneth J Cohen, George Jallo, Kathleen Dorris, Michael Handler, Melanie Comito, Mark Dias, Kellie Nazemi, Lissa Baird, Jeff Murray, Neal Lindeman, Jason L Hornick, Hayley Malkin, Claire Sinai, Lianne Greenspan, Karen D Wright, Michael Prados, Pratiti Bandopadhayay, Keith L Ligon, Mark W Kieran
Background: Diagnosis of diffuse intrinsic pontine gliomas (DIPG) has relied on imaging studies since the appearance is pathognomonic, and surgical risk was felt to be high and unlikely to affect therapy. The DIPG Biology and Treatment Study (DIPG-BATS) reported here incorporated a surgical biopsy at presentation and stratified subjects to receive FDA-approved agents chosen on the basis of specific biologic targets. Methods: Subjects were eligible for the trial if the clinical features and imaging appearance of a newly diagnosed tumor were consistent with a DIPG...
May 5, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29734497/pseudoprogression-of-brain-tumors
#20
Stefanie C Thust, Martin J van den Bent, Marion Smits
This review describes the definition, incidence, clinical implications, and magnetic resonance imaging (MRI) findings of pseudoprogression of brain tumors, in particular, but not limited to, high-grade glioma. Pseudoprogression is an important clinical problem after brain tumor treatment, interfering not only with day-to-day patient care but also the execution and interpretation of clinical trials. Radiologically, pseudoprogression is defined as a new or enlarging area(s) of contrast agent enhancement, in the absence of true tumor growth, which subsides or stabilizes without a change in therapy...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
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