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https://www.readbyqxmd.com/read/28431605/global-brain-atrophy-and-metabolic-dysfunction-in-lgi1-encephalitis-a-prospective-multimodal-mri-study
#1
Monika Szots, Morten Blaabjerg, Gergely Orsi, Pernille Iversen, Daniel Kondziella, Camilla G Madsen, Ellen Garde, Peter O Magnusson, Peter Barsi, Ferenc Nagy, Hartwig R Siebner, Zsolt Illes
BACKGROUND: Chronic cognitive deficits are frequent in leucin-rich glioma-inactivated 1 protein (LGI1) encephalitis. We examined structural and metabolic brain abnormalities following LGI1 encephalitis and correlated findings with acute and follow-up clinical outcomes. METHODS: Nine patients underwent prospective multimodal 3 Tesla MRI 33.1±18months after disease onset, including automated volumetry, diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427970/structured-evaluation-of-glioma-patients-by-an-occupational-therapist-is-our-clinical-examination-enough
#2
Christian Franz Freyschlag, Johannes Kerschbaumer, Daniel Pinggera, Gabriele Bacher, Claudius Thomé
BACKGROUND: Preservation of neurological function is mandatory when offering a surgical intervention to patients with low-grade gliomas (LGG), given that the goal of any treatment is the patient's return to their normal everyday life. OBJECTIVE: To determine whether a structured evaluation by an occupational therapist can reveal deficits that might be overseen in routine clinical examination of patients with a surgically treated LGG. METHODS: 20 patients with radiographically suspected LGG have been examined in a standardized fashion at three stages: pre-, postoperatively and three months thereafter...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28423683/the-potential-roles-of-aquaporin-4-in-malignant-gliomas
#3
REVIEW
Yu-Long Lan, Xun Wang, Jia-Cheng Lou, Xiao-Chi Ma, Bo Zhang
Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system and is primarily expressed in astrocytes. Recently, accumulated evidence has pointed to AQP4 as a key molecule that could play a critical role in glioma development. Discoveries of the role of AQP4 in cell migration suggest that AQP4 could be a significant factor regarding glioma malignancies. However, the AQP4 expression levels in glioma have not been fully elucidated; furthermore, the correlation of AQP4 expression with glioma malignancy remains controversial...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415661/specific-amplifications-and-copy-number-decreases-during-human-neural-stem-cells-differentiation-towards-astrocytes-neurons-and-oligodendrocytes
#4
Ulrike Fischer, Ella Kim, Andreas Keller, Eckart Meese
There is growing evidence that gene amplifications are an attribute of normal cells during development and differentiation. During neural progenitor cell differentiation half of the genome is involved in amplification process. To answer the question how specific amplifications occur at different stages and in different lineages of differentiation we analyzed the genes CDK4, MDM2, EGFR, GINS2, GFAP, TP53, DDB1 and MDM4 in human neural stem cells that were induced to differentiate towards astrocytes, neurons and oligodendrocytes...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410200/snord47-a-box-c-d-snorna-suppresses-tumorigenesis-in-glioblastoma
#5
Bin Xu, Min-Hua Ye, Shi-Gang Lv, Qi-Xue Wang, Miao-Jing Wu, Bing Xiao, Chun-Sheng Kang, Xin-Gen Zhu
SNORD47 is a member of the C/D box small nucleolar RNAs, which have been implicated in cancer development. We intended to investigate the therapeutic potential of SNORD47 in glioma. We found that the expression of SNORD47 was downregulated in glioma tissues samples and inversely associated with advanced tumor stage (WHO grade IV). Kaplan-Meier survival analysis revealed that glioma patients with high SNORD47 expression had longer overall survival than those with low SNORD47 expression. SNORD47 suppressed the proliferation of glioma cells and induced G2 phase arrest...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401060/therapeutic-targeting-of-histone-modifications-in-adult-and-pediatric-high-grade-glioma
#6
REVIEW
Maria J Williams, Will G B Singleton, Stephen P Lowis, Karim Malik, Kathreena M Kurian
Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG). Histone lysine methylation has emerged as an important player in regulating gene expression and chromatin function. Lysine (K) 27 (K27) is a critical residue in all seven histone 3 variants and the subject of posttranslational histone modifications, as it can be both methylated and acetylated. In pediatric HGG, two critical single-point mutations occur in the H3F3A gene encoding the regulatory histone variant H3...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28394434/case-control-study-on-occupational-exposure-to-extremely-low-frequency-electromagnetic-fields-and-glioma-risk
#7
Michael Carlberg, Tarmo Koppel, Mikko Ahonen, Lennart Hardell
BACKGROUND: Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) was in 2002 classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO. METHODS: Life time occupations were assessed in case-control studies during 1997-2003 and 2007-2009. An ELF-EMF Job-Exposure Matrix was used for associating occupations with ELF exposure (μT). Cumulative exposure (μT-years), average exposure (μT), and maximum exposed job (μT) were calculated...
April 10, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28391601/retrospective-evaluation-of-cerebral-tumors-resect-a-clinical-database-of-pre-operative-mri-and-intra-operative-ultrasound-in-low-grade-glioma-surgeries
#8
Yiming Xiao, Maryse Fortin, Geirmund Unsgård, Hassan Rivaz, Ingerid Reinertsen
PURPOSE: The advancement of medical image processing techniques, such as image registration, can effectively help improve the accuracy and efficiency of brain tumor surgeries. However, it is often challenging to validate these techniques with real clinical data due to the rarity of such publicly available repositories. ACQUISITION AND VALIDATION METHODS: Pre-operative magnetic resonance images (MRI), and intra-operative ultrasound (US) scans were acquired from 23 patients with low-grade glioma who underwent surgeries at St...
April 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28386351/inhibition-of-mir-630-enhances-the-cell-resistance-to-radiation-by-directly-targeting-cdc14a-in-human-glioma
#9
Lei Zhang, Chao Wang, Zhi-Xiao Xue
Radio-resistance becomes a large obstacle for effective cancer treatment. MicroRNAs (miRNAs) play important roles in response to radiation. However, the underlying mechanism of miR-630 on the radio-resistance of human glioma is less elucidated. In this study, we found that miR-630 was downregulated in glioma cell lines after radiation. MiR-630 inhibition enhanced the survival fraction, cell number in S stage and colony formation ability in glioma cells after radiation, while miR-630 overexpression resulted in inverse effects...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28370670/origin-and-characterization-of-alpha-smooth-muscle-actin-positive-cells-during-murine-lung-development
#10
Alena Moiseenko, Vahid Kheirollahi, Cho-Ming Chao, Negah Ahmadvand, Jennifer Quantius, Jochen Wilhelm, Susanne Herold, Katrin Ahlbrecht, Rory E Morty, Albert A Rizvanov, Parviz Minoo, Elie El Agha, Saverio Bellusci
ACTA2 expression identifies pulmonary airway and vascular smooth muscle cells (SMCs) as well as alveolar myofibroblasts (MYF). Mesenchymal progenitors expressing fibroblast growth factor 10 (Fgf10), Wilms tumor 1 (Wt1), or glioma-associated oncogene 1 (Gli1) contribute to SMC formation from early stages of lung development. However, their respective contribution and specificity to the SMC and/or alveolar MYF lineages remain controversial. In addition, the contribution of mesenchymal cells undergoing active WNT signaling remains unknown...
April 3, 2017: Stem Cells
https://www.readbyqxmd.com/read/28367093/bex2-promotes-tumor-proliferation-in-colorectal-cancer
#11
Yeting Hu, Qian Xiao, Haiyan Chen, Jinjie He, Yinuo Tan, Yue Liu, Zhanhuai Wang, Qi Yang, Xiangfeng Shen, Yu Huang, Ying Yuan, Kefeng Ding
BEX2 has been suggested to promote the tumor growth in breast cancer and glioblastoma, while inhibit the proliferation of glioma cells. Thus, the role of BEX2 in tumor was still in debate. Additionally, the biological functions of BEX2 in colorectal cancer (CRC) have not yet been clarified. Here, we reported that BEX2 was overexpressed in advanced CRC from both the GSE14333 database and fresh CRC tissue specimens, and positively correlated with clinical staging. Knockdown of BEX2 significantly decreased the in vitro proliferation of SW620 colorectal cancer cells, suppressed subcutaneous xenograft growth and enhanced the survival of mice with cecal tumors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28358704/prevalence-of-neurotropic-viruses-in-malignant-glioma-and-their-onco-modulatory-potential
#12
Tadej Strojnik, Darja Duh, Tamara T Lah
BACKGROUND: the association between infectious agents and tumour aetiology is relevant in about 20% of cases. PATIENTS AND METHODS: We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling. RESULTS: Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28349823/upregulation-of-long-noncoding-rna-zinc-finger-antisense-1-enhances-epithelial-mesenchymal-transition-in-vitro-and-predicts-poor-prognosis-in-glioma
#13
Qiao-Li Lv, Shu-Hui Chen, Xue Zhang, Bao Sun, Lei Hu, Qiang Qu, Yuan-Tao Huang, Gui-Hua Wang, Yan-Ling Liu, Ying-Ying Zhang, Hong-Hao Zhou
Increasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers. Zinc finger antisense 1 is a novel long noncoding RNA whose clinical significance, biological function, and underlying mechanism are still undetermined in glioma. In this study, we reported that zinc finger antisense 1 expression was markedly upregulated in glioma and tightly correlated with clinical stage. Moreover, patients with high zinc finger antisense 1 expression had shorter survival...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28346917/endocrine-long-term-follow-up-of-children-with-neurofibromatosis-type-1-and-optic-pathway-glioma%C3%A2
#14
Ilaria Sani, Assunta Albanese
BACKGROUND/AIMS: Children with optic pathway glioma (OPG) face sequelae related to tumour location and treatment modalities. We aimed to assess the prevalence of hypothalamic-pituitary dysfunctions in children with neurofibromatosis type 1 (NF1) and OPG who did not receive radiotherapy or surgical resection. The causative role of tumour location on endocrinopathy development is investigated. METHODS: A retrospective follow-up study of 40 children with NF1 and OPG evaluated between August 1996 and May 2015 was undertaken...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28341638/tet1-exerts-its-tumor-suppressor-function-by-regulating-autophagy-in-glioma-cells
#15
Rui Fu, Yan Ding, Jie Luo, Li Yu, Cheng Lin Li, Dong Sheng Li, Shi Wen Wen Guo
BACKGROUND: DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. TET1 catalyzes the sequential oxidation of 5-methylcytosine to 5-hydroxymethyl-cytosine, leading to eventual DNA demethylation. It has reported that TET1 is a tumor suppressor in several cancers. However, whether TET1 play a role in glioma development is largely unclear. METHODS: Different glioma specimens and corresponding normal contols were collected to analysis the expression of TET1...
March 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28338200/glioma-cells-promote-angiogenesis-through-the-release-of-exosomes-containing-long-non-coding-rna-pou3f3
#16
H-L Lang, G-W Hu, Y Chen, Y Liu, W Tu, Y-M Lu, L Wu, G-H Xu
OBJECTIVE: Angiogenesis is a key event in the progression of gliomas, and emerging evidence suggests that exosomes are signaling extracellular organelles that modulate the tumor microenvironment and promote angiogenesis and tumor progression. This study aimed to explore the mechanism by which glioma-derived exosomes affect angiogenesis. MATERIALS AND METHODS: qRT-PCR was used to determine the expression level of linc-POU3F3 in glioma tissue as well as glioma cell lines...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28324583/revisiting-cdk-inhibitors-for-treatment-of-glioblastoma-multiforme
#17
REVIEW
Dorota Lubanska, Lisa Porter
Despite extensive efforts and continual progress in research and medicine, outcomes for patients with high-grade glioma remain exceptionally poor. Over the past decade, research has revealed a great deal about the complex biology behind glioma development, and has brought to light some of the major barriers preventing successful treatment. Glioblastoma multiforme (GBM) (stage 4 astrocytoma) is a highly dynamic tumour and one of the most extreme examples of intratumoural heterogeneity, making targeting with specific therapeutics an inefficient and highly unpredictable goal...
March 21, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28319187/the-impact-of-high-grade-glial-neoplasms-on-human-cortical-electrophysiology
#18
S Kathleen Bandt, Jarod L Roland, Mrinal Pahwa, Carl D Hacker, David T Bundy, Jonathan D Breshears, Mohit Sharma, Joshua S Shimony, Eric C Leuthardt
OBJECTIVE: The brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from electrodes placed on the surface of the brain, or electrocorticography (ECoG). These resting state networks exhibit a robust functional architecture that persists through all stages of sleep and under anesthesia. While the stability of these networks provides a fundamental understanding of the organization of the brain, understanding how these regions can be perturbed is also critical in defining the brain's ability to adapt while learning and recovering from injury...
2017: PloS One
https://www.readbyqxmd.com/read/28303930/hcmv-encoded-mir-ul112-3p-promotes-glioblastoma-progression-via-tumour-suppressor-candidate-3
#19
Qing Liang, Kejia Wang, Bin Wang, Qiliang Cai
Glioblastoma (GBM) is the most prevalent and lethal type of primary malignant brain tumour. Recent studies suggest that the discovery of human cytomegalovirus (HCMV)-encoded microRNAs (miRNAs) might play a role in the pathogenesis of diseases, including GBM. In this study, we aimed to analyse the expression and function of HCMV-encoded miRNAs in GBM. We found that miR-UL112-3p expression was significantly elevated in GBM, and its expression levels were highly associated with glioma size, differentiation, WHO stage and the overall and disease-free survival of patients...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293705/idh-mutation-is-paradoxically-associated-with-higher-18-f-fdopa-pet-uptake-in-diffuse-grade-ii-and-grade-iii-gliomas
#20
A Verger, Ph Metellus, Q Sala, C Colin, E Bialecki, D Taieb, O Chinot, D Figarella-Branger, E Guedj
PURPOSE: The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH mutation as a favourable factor. Amino acid PET is increasingly used in the management of gliomas, but its prognostic value is a matter of debate. The aim of this study was to assess the relationship between IDH mutation and (18)F-FDOPA uptake on PET in newly diagnosed gliomas...
March 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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