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https://www.readbyqxmd.com/read/29016886/a-proposed-framework-of-supportive-and-palliative-care-for-people-with-high-grade-glioma
#1
Jennifer Philip, Anna Collins, Caroline Brand, Vijaya Sundararajan, Carrie Lethborg, Michelle Gold, Rosalind Lau, Gaye Moore, Michael Murphy
Background: Patients with high-grade malignant glioma (HGG) have significant supportive and palliative care needs yet few tailored guidelines exist to inform practice. This study sought to develop a HGG framework of supportive and palliative care informed by patient, family and health care professional (HCP) reported needs. Methods: This study integrates a mixed-methods research program involving: (1) Qualitative study: exploring experiences through systematic literature review and qualitative study (10 patients, 23 carers and 36 HCPs); (2) Epidemiological cohort study (N=1,821) describing care of cases of HGG in Victoria, Australia using linked hospital datasets...
July 27, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29016845/pediatric-low-grade-gliomas-next-biologically-driven-steps
#2
David T W Jones, Mark W Kieran, Eric Bouffet, Sanda Alexandrescu, Pratiti Bandopadhayay, Miriam Bornhorst, David Ellison, Jason Fangusaro, Michael I Fisher, Nicholas Foreman, Maryam Fouladi, Darren Hargrave, Cynthia Hawkins, Nada Jabado, Maura Massimino, Sabine Mueller, Giorgio Perilongo, Antoinette Y N Schouten-van Meeteren, Uri Tabori, Katherine Warren, Angela J Waanders, David Walker, William Weiss, Olaf Witt, Karen Wright, Yuan Zhu, Daniel C Bowers, Stefan M Pfister, Roger J Packer
Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neurooncology due to co-morbidities associated with these tumors and/or their treatments, and their propensity to multiply recur. LGGs, in total the most common brain tumors arising in childhood, can often become a chronic problem requiring decades of management. The 2nd international consensus conference on pediatric low-grade gliomas held in Padua, Italy in 2016, was convened in an attempt to advance the pace of translating biological discoveries on LGGs into meaningful clinical benefit...
August 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28991229/hypoxia-activates-cadherin-22-synthesis-via-eif4e2-to-drive-cancer-cell-migration-invasion-and-adhesion
#3
N J Kelly, J F A Varga, E J Specker, C M Romeo, B L Coomber, J Uniacke
Hypoxia is a driver of cell movement in processes such as development and tumor progression. The cellular response to hypoxia involves a transcriptional program mediated by hypoxia-inducible factors, but translational control has emerged as a significant contributor. In this study, we demonstrate that a cell-cell adhesion molecule, cadherin-22, is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2. We identify new functions of cadherin-22 as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28983596/cisd2-promotes-the-proliferation-of-glioma-cells-via-suppressing-beclin%C3%A2-1%C3%A2-mediated-autophagy-and-is-targeted-by-microrna%C3%A2-449a
#4
Ai-Gang Sun, Fan-Guo Meng, Ming-Guang Wang
CDGSH iron sulfur domain 2 (CISD2) has been found to be important in carcinogenesis. However, the role of CISD2 in glioma remains to be elucidated. The present study aimed to investigate the role of CISD2 in glioma using the reverse transcription‑quantitative polymerase chain reaction, western blotting, co‑immunoprecipitation assay, immunofluorescence staining and other methods. The results demonstrated that the mRNA and protein levels of CISD2 were found to be upregulated in glioma tissues, compared with the levels in matched normal tissues...
September 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28965964/gli1-is-a-potential-cancer-stem-cell-marker-and-predicts-poor-prognosis-in-ductal-breast-carcinoma
#5
Weidong Ni, Zhaoting Yang, Wenbo Qi, Chunai Cui, Yan Cui, Yanhua Xuan
Glioma-associated oncogene homolog 1 (Gli1) maintains the cancer stem cell-like characteristics in various tumors. However, its expression in cancer stem cells (CSC) in ductal breast carcinoma has not been well studied. We aimed to characterize Gli1 as a potential CSC marker and investigate its clinical significance in ductal breast carcinoma. Immunohistochemical staining was used to study the relationship of Gli1 to clinicopathologic features, cell cycle regulation-related genes, and CSC markers. Gli1 was expressed to a greater extent in ductal breast carcinoma than in normal breast tissues (P=...
September 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/28963852/advanced-and-amplified-bold-fluctuations-in-high-grade-gliomas
#6
Lalit Gupta, Rakesh K Gupta, Alida A Postma, Prativa Sahoo, Pradeep K Gupta, Rana Patir, Sunita Ahlawat, Indrajit Saha, Walter H Backes
BACKGROUND: Glioma grade along with patient's age and general health are used for treatment planning and prognosis. PURPOSE: To characterize and quantify the spontaneous blood oxygen level-dependent (BOLD) fluctuations in gliomas using measures based on T2*-weighted signal time-series and to distinguish between high- and low-grade gliomas. STUDY TYPE: Retrospective. SUBJECTS: Twenty-one patients with high-grade and 13 patients with low-grade gliomas confirmed on histology were investigated...
September 30, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28959170/expression-of-loc285758-a-potential-long-non-coding-biomarker-is-methylation-dependent-and-correlates-with-glioma-malignancy-grade
#7
Alenka Matjasic, Mara Popovic, Bostjan Matos, Damjan Glavac
BACKGROUND: Identifying the early genetic drivers can help diagnose glioma tumours in their early stages, before becoming malignant. However, there is emerging evidence that disturbance of epigenetic mechanisms also contributes to cell's malignant transformation and cancer progression. Long non-coding RNAs are one of key epigenetic modulators of signalling pathways, since gene expression regulation is one of their canonical mechanisms. The aim of our study was to search new gliomagenesis-specific candidate lncRNAs involved in epigenetic regulation...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28956430/multiplexed-electrochemical-detection-of-mirnas-from-sera-of-glioma-patients-at-different-stages-via-the-novel-conjugates-of-conducting-magnetic-microbeads-and-diblock-oligonucleotide-modified-gold-nanoparticles
#8
Jingrui Wang, Zhixuan Lu, Hailin Tang, Ling Wu, Zixiao Wang, Minghua Wu, Xinyao Yi, Jianxiu Wang
MicroRNAs (miRNAs) serve as diagnostic and prognostic biomarkers for a wide variety of cancers. Via the novel conjugates of gold nanoparticle-coated magnetic microbeads (AuNP-MMBs) and the diblock oligonucleotide (ODN)-modified AuNPs, multiplexed electrochemical assay of miRNAs was performed. The hybridization to target miRNAs leads to the conformational change of the hairpin-structured ODN probes, and the attachment of the diblock ODN-modified AuNPs was achieved. By examining the oxidation peak currents of methylene blue (MB) and ferrocene (Fc) moieties residing on the diblock ODNs, simultaneous quantification of miRNA-182 and miRNA-381 was conducted...
October 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28939851/isomers-identification-of-2-hydroxyglutarate-acid-disodium-salt-2hg-by-terahertz-time-domain-spectroscopy
#9
Wanqing Chen, Yan Peng, Xiankai Jiang, Jiayu Zhao, Hongwei Zhao, Yiming Zhu
2-Hydroxyglutaric acid disodium salt (2HG) is a unique biomarker existing in glioma, which can be used for recognizing cancer development stage and identifying the boundary between the ordinary tissue and cancer tissue. However, the most efficient detection method for 2HG now is Magnetic Resonance Spectroscopy (MRS), whose testing time is at least twenty minutes and the variability of 2HG (continuous synthesis and decomposition) determines it cannot be used as the real-time image in medical surgery. In this paper, by using the Terahertz Time-domain Spectroscopy (THz-TDS) System, we investigate the vibration spectra of 2HG isomers and further distinguish their physical properties by using Density Functional Theory...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927746/-proposal-of-screening-for-diffuse-low-grade-gliomas-in-the-population-from-20-to-40years
#10
Emmanuel Mandonnet, Luc Taillandier, Hugues Duffau
Diffuse low-grade gliomas (DLGG) are cerebral tumors occurring in young adults, with an inescapable progression to higher grade of malignancy, resulting in functional impairment and death. DLGG evolve in several phases: an asymptomatic period despite a slow radiological growth; a period in which inaugural symptoms occur, usually epilepsy with possible mild cognitive disorders; then a phase with malignant transformation generating disabling neurological deficits; and ultimately the terminal stage. Early maximal surgical resection significantly increases overall survival while preserving quality of life...
September 15, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28918420/computer-analysis-of-glioma-transcriptome-profiling-alternative-splicing-events
#11
Vladimir N Babenko, Natalya V Gubanova, Anatoly O Bragin, Irina V Chadaeva, Gennady V Vasiliev, Irina V Medvedeva, Alexey S Gaytan, Alexey L Krivoshapkin, Yuriy L Orlov
Here we present the analysis of alternative splicing events on an example of glioblastoma cell culture samples using a set of computer tools in combination with database integration. The gene expression profiles of glioblastoma were obtained from cell culture samples of primary glioblastoma which were isolated and processed for RNA extraction. Transcriptome profiling of normal brain samples and glioblastoma were done by Illumina sequencing. The significant differentially expressed exon-level probes and their corresponding genes were identified using a combination of the splicing index method...
September 18, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28885661/egfr-as-a-clinical-marker-in-glioblastomas-and-other-gliomas
#12
Fadi S Saadeh, Rami Mahfouz, Hazem I Assi
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells, which show a range of aggressiveness depending on grade and stage. Many EGFR gene alterations have been identified in gliomas, especially glioblastomas, including amplifications, deletions and single nucleotide polymorphisms (SNPs). Glioblastomas are discussed as a separate entity due to their high correlation with EGFR mutants and the reported association of the latter with survival and response to treatment in this glioma subgroup...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28845594/textural-features-of-dynamic-contrast-enhanced-mri-derived-model-free-and-model-based-parameter-maps-in-glioma-grading
#13
Tian Xie, Xiao Chen, Jingqin Fang, Houyi Kang, Wei Xue, Haipeng Tong, Peng Cao, Sumei Wang, Yizeng Yang, Weiguo Zhang
BACKGROUND: Presurgical glioma grading by dynamic contrast-enhanced MRI (DCE-MRI) has unresolved issues. PURPOSE: The aim of this study was to investigate the ability of textural features derived from pharmacokinetic model-based or model-free parameter maps of DCE-MRI in discriminating between different grades of gliomas, and their correlation with pathological index. STUDY TYPE: Retrospective. SUBJECTS: Forty-two adults with brain gliomas...
August 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28841806/endothelin-b-receptor-promotes-the-proliferation-and-immune-escape-of-malignant-gliomas
#14
Dong-Sheng Pan, Si-Zhe Feng, Peng Cao, Jin-Jiang Li
PURPOSE: As a kind of difficult to cure tumour, malignant gliomas have attracted widespread attention. The proliferation and immune escape of tumour cells were closely related to the development of malignant gliomas. The aim of this study was to investigate the role of endothelin B receptor (NTBR) in gliomas. METHODS: RT-PCR was used to detect the expression of NTBR mRNA in glioma tissue and glioma cell lines. The expression of NTBR in glioma tissues was detected by immunohistochemistry...
August 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28831723/functional-mri-for-surgery-of-gliomas
#15
REVIEW
Antonella Castellano, Sara Cirillo, Lorenzo Bello, Marco Riva, Andrea Falini
PURPOSE OF REVIEW: Advanced neuroimaging techniques such as functional MRI (fMRI) and diffusion MR tractography have been increasingly used at every stage of the surgical management of brain gliomas, as a means to improve tumor resection while preserving brain functions. This review provides an overview of the last advancements in the field of functional MRI techniques, with a particular focus on their current clinical use and reliability in the preoperative and intraoperative setting, as well as their future perspectives for personalized multimodal management of patients with gliomas...
August 23, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28818988/multiregional-tumor-drug-uptake-imaging-by-pet-and-microvascular-morphology-in-end-stage-diffuse-intrinsic-pontine-glioma
#16
Sophie E M Veldhuijzen van Zanten, A Charlotte P Sewing, Arthur van Lingen, Otto S Hoekstra, Pieter Wesseling, Michaël H Meel, Dannis G van Vuurden, Gertjan J L Kaspers, Esther Hulleman, Marianna Bugiani
Inadequate tumor uptake of the vascular endothelial growth factor (VEGF) antibody bevacizumab could explain lack of effect in diffuse intrinsic pontine glioma (DIPG). Methods: By combining data from a positron emission tomography (PET) imaging study using zirconium-89((89)Zr)-labeled bevacizumab and an autopsy study, a 1-on-1 analysis of multiregional in vivo and ex vivo (89)Zr-bevacizumab uptake, tumor histology and vascular morphology in a DIPG patient was performed. Results: In vivo (89)Zr-bevacizumab measurements showed heterogeneity between lesions...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28772286/prevalence-of-cancer-at-baseline-screening-in-the-national-cancer-institute-li-fraumeni-syndrome-cohort
#17
Phuong L Mai, Payal P Khincha, Jennifer T Loud, Rosamma M DeCastro, Renée C Bremer, June A Peters, Chia-Ying Liu, David A Bluemke, Ashkan A Malayeri, Sharon A Savage
Importance: Establishment of an optimal cancer surveillance program is important to reduce cancer-related morbidity and mortality in individuals with Li-Fraumeni syndrome, a rare, highly penetrant cancer predisposition syndrome. Objective: To determine the feasibility and efficacy of a comprehensive cancer screening regimen in Li-Fraumeni syndrome, using multiple radiologic techniques, including rapid whole-body magnetic resonance imaging (MRI) and laboratory measurements...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28756927/the-relationship-between-fractional-anisotropy-value-and-tumor-microarchitecture-in-late-stage-rat-glioma
#18
Xiang-Ying Li, Jian-Qiang Chen, Yi-Kai Xu, Xiang-Jun Han
OBJECTIVE: To explore the magnetic resonance diffusion tensor imaging (MR-DTI) features of in the late stage of Wistar rat C6 brain glioma, and the relationship between fractional anisotropy value and tumor microarchitecture. METHODS: The concentration of more than 1.0 × 10(6)/10 μL glioma cells and complete medium were injected stereotactically into the right caudate nucleus of the experimental group (n = 35) and control group (n = 10), respectively. Conventional MRI, DTI, and enhanced T1WI scans were Performed using the GE Signa HD × 3...
June 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28751207/analysis-of-the-expression-of-hax-1-gene-in-human-glioma
#19
Xin Deng, Laijun Song, Ying Wei, Xin-Bin Guo
Glioma, as the most common aggressive malignant tumor in the central nervous system, is still an insurmountable issue in neural diseases. The proliferation and survival mechanism of glioma cells need to be explored further for the development of glioma treatment. Hematopoietic cell-specific protein 1 associated protein X-1 (HAX-1) is well known for its anti-apoptotic effect. It was reported to play an important role in several malignant tumors. However, the effect of HAX-1 in glioma still remains unknown. This study aimed to investigate the expression of HAX-1 in glioma and the correlation between HAX-1 and the clinicopathological characteristics and prognosis of glioma...
July 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28750338/mos2-la-pei-nanocomposite-carrier-for-real-time-imaging-of-atp-metabolism-in-glioma-stem-cells-co-cultured-with-endothelial-cells-on-a-microfluidic-system
#20
Nan Li, Weifei Zhang, Mashooq Khan, Ling Lin, Jin-Ming Lin
Stimuli-responsive carriers have extensively attracted attention in recent years. However, long-term and real-time tracking ability with stimuli-responsive carrier is still in its infant stage due to the limitations such as, low efficacy, instability and cytotoxicity in a bio-environment. In this work, we developed a reduction-sensitive carrier composed of lipoic acid-modified low molecular weight polyethyleneimine (LA-PEI) and large surface ratio MoS2 nanosheet integrated via disulfide bond to mimic a high molecular weight PEI...
July 19, 2017: Biosensors & Bioelectronics
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