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https://www.readbyqxmd.com/read/29475202/postpartum-genital-melanoma-a-case-report
#1
Gisele Alborghetti Nai, Andressa Bazan, Caroline Andrade Rocha, Juliana Souza Nagy, Isadora Tanaka Campos
Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix. Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old female presented with vaginal bleeding 2 months after a term cesarean delivery. An endovaginal ultrasound revealed a lesion in the uterine cervix. The pathological report revealed a small round-cell neoplasm, and the immunohistochemistry confirmed the diagnosis of malignant melanoma. A positron emission tomography revealed an expansive hypermetabolic lesion centered on the cervix, and hypermetabolic lesions in the liver and right kidney...
February 23, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29475140/the-prognostic-relevance-of-sentinel-lymph-node-metastases-assessed-by-phgr1-mrna-quantification-in-stage-i-to-iii-colon-cancer
#2
Satu Oltedal, Hartwig Kørner, Ole Gunnar Aasprong, Israr Hussain, Kjersti Tjensvoll, Rune Smaaland, Jon Arne Søreide, Kjetil Søreide, Ragnhild A Lothe, Reino Heikkilä, Bjørnar Gilje, Oddmund Nordgård
BACKGROUND: Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph node (SLN) metastases in colon cancer patients by measuring the novel metastasis marker PHGR1 mRNA. METHODS: Using quantitative reverse-transcription polymerase chain reaction, we measured PHGR1 mRNA levels in SLNs and primary tumors from 206 patients surgically treated for stage I to III colon cancer and 52 normal LNs from patients undergoing surgery for benign colon diseases...
February 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29475110/pathological-fracture-risk-assessment-in-patients-with-femoral-metastases-using-ct-based-finite-element-methods-a-retrospective-clinical-study
#3
Amir Sternheim, Ornit Giladi, Yair Gortzak, MIchael Drexler, Moshe Salai, Nir Trabelsi, Charles Milgrom, Zohar Yosibash
Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery. CT-based finite element analyses (CTFEA) have been shown to accurately predict strength in femurs with metastatic tumors in an ex-vivo study. In order to assess the utility of CTFEA as a clinical tool to determine the need for fixation of patients with MBD of the femur, an ad hoc CTFEA was performed on a retrospective cohort of fifty patients...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475080/partial-maxillectomy-for-ameloblastoma-of-the-maxilla-with-infratemporal-fossa-involvement-a-combined-endoscopic-endonasal-and-transoral-approach
#4
Anasuya Guha, Libor Hart, Helena Polachova, Martin Chovanec, Petr Schalek
BACKGROUND: Ameloblastoma represents the most common epithelial odontogenic tumor. Because of the proximity of the maxillary tumors to the orbit and skull base, it should be managed as radically as possible. Maxillectomy mainly via the transfacial or transoral approach represents the most common type of surgical procedure. Drawback of these approaches is limited control of the superiomedial extent of the tumour in the paranasal area. We report the use of a combined endoscopic endonasal and transoral approach to manage maxillary plexiform ameloblastoma in a 48 year old male patient...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475026/results-of-interdisciplinary-management-of-693-patients-with-aneurysmal-subarachnoid-hemorrhage-clinical-outcome-and-relevant-prognostic-factors
#5
Muhammad AlMatter, Marta Aguilar Péreza, Pervinder Bhogal, Victoria Hellstern, Oliver Ganslandt, Hans Henkes
OBJECTIVES: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high rates of morbidities and fatalities. The continuous evolution of neurosurgical, endovascular and neuro-intensive cares has improved the overall mortality. In this study we sought to evaluate the clinical outcome after aSAH from a single tertiary center. PATIENTS AND METHODS: We retrospectively identified and reviewed all consecutive patients with aSAH treated at our center between 2007 and 2016...
February 13, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29474946/functional-results-and-patient-satisfaction-after-long-fusion-for-spinal-deformity-in-parkinson-s-disease
#6
C Scemama, G Mangone, R Bonaccorsi, H Pascal-Moussellard
BACKGROUND: Patients with Parkinson's disease often present abnormal posture or severe sagittal malalignment, causing significant disability. Surgical fusion is these cases shows high rates of complications, but may nevertheless provide functional benefit; however, this remains to be assessed. HYPOTHESIS: Long fusion for patients with Parkinson's disease and postural disorder could alleviate disability despite the high risk of complications. METHODS: We retrospectively reviewed 18 Parkinson patients treated by long fusion for spinal deformity...
February 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29474882/the-angiographic-and-clinical-outcomes-of-intracranial-aneurysms-following-irradiation-in-patients-with-nasopharyngeal-carcinoma-a-13-year-experience-and-literature-review
#7
Chan Siang Hua Victor, Woo Yat Ming Peter, Wong Kai Sing Alain, Chan Kwong Yau, Leung Kar Ming
BACKGROUND AND PURPOSE: Intracranial aneurysms are a known but rare complication of radiotherapy (RT). We reviewed the angiographic and clinical outcomes of intracranial aneurysms following RT in patients with nasopharyngeal carcinoma (NPC), a malignancy endemic in Hong Kong. MATERIALS AND METHODS: The clinical, angiographic and laboratory data was collected for nine NPC patients harboring fifteen intracranial aneurysms following RT, diagnosed between 1st January 2000 and 31st December 2012...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474847/serum-mirna-predicts-viable-disease-post-chemotherapy-in-testicular-non-seminoma-germ-cell-tumor-patients
#8
Ricardo Leão, Ton van Agthoven, Arnaldo Figueiredo, Michael A S Jewett, Kamel Fadaak, Joan Sweet, Ardalan E Ahmad, Lynn Anson-Cartwright, Peter Chung, Aaron Hansen, Padraig Warde, Pedro Castelo-Branco, Martin O'Malley, Philippe L Bedard, Leendert H J Looijenga, Robert J Hamilton
PURPOSE: Retroperitoneal lymph node dissection (RPLND) is recommended for residual masses >1cm post-chemotherapy (pc) in nonseminoma germ cell tumors (NSGCT). Currently, there is no reliable predictor for pcRPLND histology and up to 50% will harbour necrosis/fibrosis only, thus rendering a potentially morbid surgery to be of limited therapeutic value. In this study we aimed to evaluate the ability of defined serum microRNAs (miRNA) to predict residual viable NSGCT after chemotherapy...
February 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474688/preoperative-use-of-neuromodulators-to-optimize-surgical-outcomes-in-upper-blepharoplasty-and-brow-lift
#9
Iliana E Sweis, Lisa Hwang, Mimis Cohen
Background: Upper eyelid dermatochalasis often triggers frontalis hyperactivity in an effort to elevate the upper lids away from the visual axis. Similarly, prior neuromodulator treatment of the brow depressors may cause false elevation of the brows, diminishing the extent of preoperative brow ptosis or dermatochalasis. Studies have quantified postoperative brow ptosis and recurrent dermatochalasis following upper blepharoplasty, but a methodology to predict the postoperative brow position remains to be elucidated...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474564/long-term-outcomes-of-total-correction-for-isolated-total-anomalous-pulmonary-venous-connection-lessons-from-50-years-experience
#10
Takahiko Sakamoto, Mitsugi Nagashima, Kentarou Umezu, Ryogo Houki, Jin Ikarashi, Junko Katagiri, Kenji Yamazaki
OBJECTIVES: Isolated total anomalous pulmonary venous connection (TAPVC) is a relatively rare congenital cardiac defect, while pulmonary venous obstruction (PVO) is associated with poor prognosis. We reviewed the long-term outcome of total correction for isolated TAPVC at our institute and analysed the risk factors for mortality and morbidity. METHODS: A total of 290 isolated TAPVC patients evaluated between 1965 and 2016 were divided into 2 groups: Group Early (n = 151) underwent surgery before 1989; Group Late (n = 139) underwent surgery after 1990...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474555/health-related-quality-of-life-of-patients-after-surgery-for-acute-type-a-aortic-dissection
#11
Uyanga Adam, Helmut Habazettl, Katharina Graefe, Hermann Kuppe, Maximilian Wundram, Stephan Dominik Kurz
OBJECTIVES: Acute Type A aortic dissection (ATAAD) and the ensuing surgical therapy may be experienced as a traumatic event by patients. This study aimed at analysing the prevalence of post-traumatic stress disorder (PTSD) and the physical and mental well-being of survivors of surgically treated ATAAD. METHODS: A total of 393 survivors were contacted and asked to fill in various health questionnaires. RESULTS: Two hundred and ten (53%) patients returned the questionnaires...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474549/pi3k-mtor-pathway-identified-as-a-potential-therapeutic-target-in-biliary-tract-cancer-using-a-newly-established-patient-derived-cell-panel-assay
#12
Yasunari Sakamoto, Seri Yamagishi, Yoshinori Tanizawa, Masaomi Tajimi, Takuji Okusaka, Hidenori Ojima
Biliary tract carcinoma (BTC) is an extremely malignant tumor, but available treatment options are limited. Despite of needs for novel therapies, few BTC-related resources are currently available for evaluation of candidate drugs. To address this issue, we have recently established 13 cell lines from surgical specimens from Japanese BTC patients. In the present study, we evaluated four new molecular targeting agents using our BTC cell-based assay panel with 17 BTC cell lines. PI3K/mTOR dual inhibitor LY3023414 showed activity at submicromolar concentration ranges against 13 of the 17 cell lines tested, including the ones with gemcitabine insensitivity...
February 21, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29474527/aesthetic-improvement-of-undeveloped-calves-after-treatment-of-congenital-clubfoot-deformity
#13
Katarina Andjelkov, Ramon Llull, Milan Colic, Tatjana C Atanasijevic, Vesna M Popovic, Miodrag Colic
Background: Even when clubfoot deformity is treated in a timely manner, the consequences observed in adulthood include hypoplasia of the calf muscles, gait impairment, decreases in foot size and can also affect the tibial length. These consequences may have negative impacts on the patient's subjective appraisal of long-term outcomes, and can influence the patient's self-esteem in both male and female patients. Objectives: We present our experience in the treatment of undeveloped calves after surgical treatment of congenital clubfoot...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474509/blepharoplasty-anatomy-planning-techniques-and-safety
#14
Mohammed Alghoul
Blepharoplasty is one of the most commonly performed cosmetic surgical procedures. To date it remains the most powerful method of periorbital rejuvenation when compared to other non-surgical modalities, especially in the aging face. Despite that, the procedure has its shortcomings that include a steep learning curve, prolonged recovery and potential for appearance and life-changing complications. Attaining successful outcomes rely on solid understanding of facial topography, patient and technique selection, and, when appropriate, following a conservative approach...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474407/predicting-excess-cost-for-older-inpatients-with-clinical-complexity-a-retrospective-cohort-study-examining-cognition-comorbidities-and-complications
#15
Kasia Bail, Brian Draper, Helen Berry, Rosemary Karmel, John Goss
BACKGROUND: Hospital-acquired complications increase length of stay and contribute to poorer patient outcomes. Older adults are known to be at risk for four key hospital-acquired complications (pressure injuries, pneumonia, urinary tract infections and delirium). These complications have been identified as sensitive to nursing characteristics such as staffing levels and level of education. The cost of these complications compared to the cost of admission severity, dementia, other comorbidities or age has not been established...
2018: PloS One
https://www.readbyqxmd.com/read/29474346/level-of-agreement-between-laboratory-and-point-of-care-prothrombin-time-in-patients-after-stopping-or-continuation-of-acenocoumarol-anticoagulation-a-comparison-of-diagnostic-accuracy
#16
Elisabeth A J de Vos, Yolien J Hagen, Michael I Meesters, Nada Osmanovic, Christa Boer, Marcel A de Leeuw
BACKGROUND: Procedures requiring optimisation of the coagulation status of patients using vitamin K antagonists are frequently postponed due to the late availability of laboratory international normalised ratio (INR) test results. A point-of-care (POC) alternative may facilitate early decision-making in peri-operative patients. OBJECTIVES: To assess the level of agreement between the POC-INR and the laboratory INR in patients who continue or stop vitamin K antagonists to determine whether the POC test may be a good alternative to the laboratory INR...
February 22, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29474320/temporal-trends-in-incidence-sepsis-related-mortality-and-hospital-based-acute-care-after-sepsis
#17
Nathaniel Meyer, Michael O Harhay, Dylan S Small, Hallie C Prescott, Kathryn H Bowles, David F Gaieski, Mark E Mikkelsen
OBJECTIVES: A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure temporal trends in sepsis survivorship and hospital-based acute care use in sepsis survivors. In addition, because readmissions after pneumonia are subject to penalty under the national readmission reduction program, we examined whether readmission rates declined after sepsis hospitalizations related to pneumonia...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474308/risk-factors-treatment-strategies-and-outcomes-of-endophthalmitis-associated-with-severe-fungal-keratitis
#18
Lei Wan, Jun Cheng, Jing Zhang, Nan Chen, Yan Gao, Li-Xin Xie
PURPOSE: To investigate risk factors, treatment strategies, and outcomes of endophthalmitis associated with severe fungal keratitis. METHODS: Data from 392 patients diagnosed with fungal keratitis were retrospectively examined. Patients had severe disease that was refractory to topical or systemic antifungal therapy, and the infection involved the endothelium or perforated the cornea. The incidence and risk factors for endophthalmitis, and treatment outcomes were evaluated...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29474300/corneal-neurotization-with-a-great-auricular-nerve-graft-effective-reinnervation-demonstrated-by-in-vivo-confocal-microscopy
#19
Hakim Benkhatar, Ora Levy, Isabelle Goemaere, Vincent Borderie, Laurent Laroche, Nacim Bouheraoua
PURPOSE: We describe the first case of minimally invasive corneal neurotization with the great auricular nerve (GAN) to treat unilateral neurotrophic keratopathy. We assessed corneal sensation and reinnervation by esthesiometry and confocal microscopy over 12 months of follow-up, and we provide a detailed description of the surgical technique. METHODS: Corneal neurotization was successfully achieved with the ipsilateral GAN in a 58-year-old woman. Cochet-Bonnet esthesiometry and in vivo confocal microscopy were performed before and after corneal neurotization, to monitor the recovery of corneal sensation and corneal reinnervation by subbasal nerve fibers...
February 22, 2018: Cornea
https://www.readbyqxmd.com/read/29474298/descemet-membrane-endothelial-keratoplasty-for-failed-deep-anterior-lamellar-keratoplasty-a-case-series
#20
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Zale Mednick, Mohammad Kreimei, Clara C Chan, David S Rootman
PURPOSE: To suggest a new surgical approach for posterior opacities or persistent Descemet membrane (DM) detachment in failed deep anterior lamellar keratoplasty (DALK) and to report the outcome of Descemet membrane endothelial keratoplasty (DMEK) in a series of patients with DALK failure. METHODS: In this retrospective case series of patients who underwent DMEK for failed DALK at Toronto Western Hospital, 4 patients with failed DALK who underwent DMEK surgery were included...
February 22, 2018: Cornea
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