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https://www.readbyqxmd.com/read/29684893/comparison-of-the-moca-and-bearni-tests-for-detection-of-cognitive-impairment-in-in-patients-with-alcohol-use-disorders
#1
Stéphanie Pelletier, Régis Alarcon, Valérie Ewert, Margot Forest, Bertrand Nalpas, Pascal Perney
INTRODUCTION: Screening of cognitive impairment is a major challenge in alcoholics seeking treatment, since cognitive dysfunction may impair the overall efficacy of rehabilitation programs and consequently increase relapse rate. We compared the performance of two screening tools: the MoCA (Montreal Cognitive Assessment), which is widely used in patients with neurological diseases and already used in patients with alcohol use disorder (AUD), and the BEARNI (Brief Evaluation of Alcohol-Related Neuropsychological Impairments), a recent test specifically developed for the alcoholic population...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684866/the-mediation-roles-of-discrepancy-stress-and-self-esteem-between-masculine-role-discrepancy-and-mental-health-problems
#2
Xue Yang, Joseph T F Lau, Zixin Wang, Yee-Ling Ma, Mason C M Lau
INTRODUCTION: Masculine role discrepancy and discrepancy stress occur when men perceive that they fail to live up to the ideal manhood derived from societal prescriptions. The present study examined the associations between masculine role discrepancy and two emotional and mental health problems (social anxiety and depressive symptoms), and potential mediation effects through discrepancy stress and self-esteem in a male general population. METHODS: Based on random population-based sampling, 2000 male residents in Hong Kong were interviewed...
April 16, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684498/multi-modal-characterization-of-vasculature-and-nanoparticle-accumulation-in-five-tumor-xenograft-models
#3
Einar Sulheim, Jana Kim, Annemieke van Wamel, Eugene Kim, Sofie Snipstad, Igor Vidic, Ingeborg Hovde Grimstad, Marius Widerøe, Sverre H Torp, Steinar Lundgren, David J Waxman, Catharina de Lange Davies
Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. A better understanding of how tumor heterogeneity affects nanoparticle accumulation could help elucidate this discrepancy and help in patient selection for nanomedicine therapy. Here we studied five human tumor models with varying morphology and evaluated the accumulation of 100 nm polystyrene nanoparticles...
April 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29682317/validation-of-quantitative-polymerase-chain-reaction-with-southern-blot-method-for-telomere-length-analysis
#4
Mohamad Tarik, Lakshmy Ramakrishnan, Harshpal S Sachdev, Nikhil Tandon, Ambuj Roy, Santosh K Bhargava, Ravindra M Pandey
Aim: Telomere length (TL) measurement by quantitative polymerase chain reaction (PCR) has been widely accepted, but limited information regarding its validation with a gold-standard technique is available. Materials & methods: We measured TL by Southern blot and monochrome multiplex quantitative PCR (MMqPCR) and validated the results of TL in leukocytes of 94 participants with mean age 43.2 years, BMI 19-41 (mean 27.8 ± 4.3) kg/m2 . Results: A significant positive correlation was observed between TL measured by MMqPCR and Southern blot assay (correlation coefficient r = +0...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682253/-in-vitro-evaluation-of-the-post-space-depth-reading-with-an-intraoral-scanner-ios-compared-to-a-traditional-silicon-impression
#5
A Pinto, L Arcuri, P Carosi, R Nardi, A Libonati, L Ottria, V Campanella
Objectives: The aim of the study was to assess the depth and quality of the post-space reading, using an IOS without scan-post, compared to a traditional silicon technique. Methods: Six extracted bicuspids were decoronated and endodontically treated. After having prepared the space for the posts, a structure in pink acrylic resin was created with two resin elements. At the center of the structure one sample was put at a time. Digital and traditional impressions were taken for each sample...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29682164/defective-autophagy-in-atherosclerosis-to-die-or-to-senesce
#6
REVIEW
Mandy O J Grootaert, Lynn Roth, Dorien M Schrijvers, Guido R Y De Meyer, Wim Martinet
Autophagy is a subcellular process that plays an important role in the degradation of proteins and damaged organelles such as mitochondria (a process termed "mitophagy") via lysosomes. It is crucial for regulating protein and mitochondrial quality control and maintaining cellular homeostasis, whereas dysregulation of autophagy has been implicated in a wide range of diseases including atherosclerosis. Recent evidence has shown that the autophagic process becomes dysfunctional during the progression of atherosclerosis, regardless of whether there are many autophagy-stimulating factors (e...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681436/compatibility-of-lauge-hansen-classification-between-plain-radiographs-and-magnetic-resonance-imaging-in-ankle-fractures
#7
Haluk Çabuk, Filiz Çelebi, Yunus İmren, Süleyman Semih Dedeoğlu, Mustafa Çağlar Kır, Abdullah Faruk Uyanık, Hakan Gürbüz
We evaluated the accuracy of the predictive injury sequences of the Lauge-Hansen (L-H) classification using magnetic resonance imaging (MRI) in patients with ankle fractures and determined the possible causes of mismatch. Sixty-five patients with ankle fractures who had a complete series of anteroposterior, lateral, and oblique radiographs and ankle MRI studies available were included. The fracture pattern was assigned by 2 senior orthopedic surgeons according to the L-H classification system. The syndesmotic ligaments, lateral collateral ligaments, and medial deltoid complex ligaments were evaluated on the preoperative MRI scans...
April 19, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29681402/-clinical-practice-for-morbidly-obese-endometrial-cancer-patients-a-french-multicentric-study
#8
Cécile Loaec, Edouard Vaucel, Eric Darnis, Patrice Lopes, Gabrielle Selmes, Isabelle Jaffre, Jean-Marc Classe
INTRODUCTION: Morbid obesity may lead to difficulties for management of endometrial cancer. The aim of this study was the assessment of management of endometrial cancer for morbidly obese women and the implementation of recommendations. METHODS: this is retrospective study including women with BMI ≥40kg/m2 treated for endometrial cancer between November 2010 and April 2017 in the university hospital in Nantes and the Cancer Center René Gauducheau in Nantes. Patients' demographics, pre-operative intra operative, post-operative data and survival were analyzed...
April 19, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29680951/urologists-attitudes-to-sexual-complications-of-luts-bph-treatments
#9
Simone Giona, Indranil Ganguly, Gordon Muir
INTRODUCTION: Many LUTS/BPH treatments currently available may affect sexual function (SD). We wished to assess urologists' attitude and practice in this area. METHODS: Attendees of an international meeting were randomly selected, interviewed and stratified by professional status and LUTS/BPH cases seen per month. There were four questions: treatment options offered, frequency of discussing erectile dysfunction (ED) with each treatment, frequency of discussing ejaculatory dysfunction (EjD) with each treatment, and offering alternative treatment based on the risks of sexual dysfunction...
April 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29680522/psychopathology-everyday-behaviors-and-autonomic-activity-in-daily-life-an-ambulatory-impedance-cardiography-study-of-depression-anxiety-and-hypomanic-traits
#10
Sarah H Sperry, Thomas R Kwapil, Kari M Eddington, Paul J Silvia
Discrepancies regarding the link between autonomic nervous system (ANS) activity and psychopathology may be due in part to inconsistent measurement of non-psychological factors, including eating, drinking, activity, posture, and interacting with others. Rather than sources of noise, behaviors like being active and being with others may be the behavioral pathways that connect psychopathology symptoms to autonomic activity. The present study examined whether behaviors mediate the association of depression, anxiety, and hypomanic traits with ANS by using experience sampling methodology and ambulatory impedance cardiography...
April 19, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29680498/sleep-eeg-spectral-power-is-correlated-with-subjective-objective-discrepancy-of-sleep-onset-latency-in-major-depressive-disorder
#11
Seung-Gul Kang, Sara Mariani, Stephanie A Marvin, Kwang-Pil Ko, Susan Redline, John W Winkelman
We aimed to identify the sleep electroencephalography (EEG) spectral power correlates of the subjective-objective discrepancy (SOD) of sleep onset latency (SOL) in major depressive disorder (MDD), primary insomnia (PI), and normal sleeping control (NSC) groups. We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups...
April 19, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29680201/inactivated-influenza-vaccine-stress-can-affect-in-vitro-potency-assay-relationship-to-immunogenicity
#12
Yingxia Wen, Giuseppe Palladino, Yuhong Xie, Annette Ferrari, Ethan C Settembre
Influenza vaccines are the most effective intervention to prevent the substantial public health burden of seasonal and pandemic influenza. The capability of hemagglutinin (HA), the main antigen in inactivated influenza vaccines (IIVs), to elicit functional neutralizing antibodies determines IIV effectiveness. When HA is subjected to environmental stress during manufacturing or while stored prior to administration, such as low pH and temperature excursions, the HA immunological activity can be affected. Single-radial immunodiffusion (SRID), the standard in vitro potency assay for IIVs, is believed to specifically detect immunologically active HA and has been applied to evaluate HA stability against stress...
April 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29679976/optoelectronics-and-defect-levels-in-hydroxyapatite-by-first-principles
#13
Leon A Avakyan, Ekaterina V Paramonova, José Coutinho, Sven Öberg, Vladimir S Bystrov, Lusegen A Bugaev
Hydroxyapatite (HAp) is an important component of mammal bones and teeth, being widely used in prosthetic implants. Despite the importance of HAp in medicine, several promising applications involving this material (e.g., in photo-catalysis) depend on how well we understand its fundamental properties. Among the ones that are either unknown or not known accurately, we have the electronic band structure and all that relates to it, including the bandgap width. We employ state-of-the-art methodologies, including density hybrid-functional theory and many-body perturbation theory within the dynamically screened single-particle Green's function approximation, to look at the optoelectronic properties of HAp...
April 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29679715/molecular-phylogeny-and-comparative-morphology-indicate-that-odontostomatids-alveolata-ciliophora-form-a-distinct-class-level-taxon-related-to-armophorea
#14
Noemi M Fernandes, Vinicius F Vizzoni, Bárbara do N Borges, Carlos A G Soares, Inácio D da Silva-Neto, Thiago da S Paiva
The odontostomatids are among the least studied ciliates, possibly due to their small sizes, restriction to anaerobic environments and difficulty in culturing. Consequently, their phylogenetic affinities to other ciliate taxa are still poorly understood. In the present study, we analyzed newly obtained ribosomal gene sequences of the odontostomatids Discomorphella pedroeneasi and Saprodinium dentatum, together with sequences from the literature, including Epalxella antiquorum and a large assemblage of ciliate sequences representing the major recognized classes...
April 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#15
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679217/spatiotemporal-imaging-of-cellular-energy-metabolism-with-genetically-encoded-fluorescent-sensors-in-brain
#16
REVIEW
Zhuo Zhang, Weicai Chen, Yuzheng Zhao, Yi Yang
The brain has very high energy requirements and consumes 20% of the oxygen and 25% of the glucose in the human body. Therefore, the molecular mechanism underlying how the brain metabolizes substances to support neural activity is a fundamental issue for neuroscience studies. A well-known model in the brain, the astrocyte-neuron lactate shuttle, postulates that glucose uptake and glycolytic activity are enhanced in astrocytes upon neuronal activation and that astrocytes transport lactate into neurons to fulfill their energy requirements...
April 20, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29678653/continued-ultrasound-surveillance-required-after-hand-ischemia-associated-with-trauma-in-children
#17
Melissa L Kirkwood, Khalil H Chamseddin, Brianne Hanson, Carlos H Timaran, Mujtaba Ali, Alexis D Jacob, John E Rectenwald
BACKGROUND: Hand ischemia following trauma in children is rare and the natural history after upper extremity arterial bypass in children is unknown. We hypothesize children with brachial artery repair are at long term risk of developing aneurysmal degeneration or Thrombosis thus necessitating annual duplex ultrasonography and physical examination. STUDY DESIGN: A retrospective review of children who had brachial artery repair (bypass or vein patch) for hand ischemia secondary to trauma at a level I trauma pediatric hospital was performed...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678625/ambulatory-blood-pressure-monitoring-profiles-in-a-cross-sectional-analysis-of-a-large-database-of-normotensive-and-true-or-suspected-hypertensive-patients
#18
Sara Araújo, Ana Rouxinol-Dias, José Mesquita-Bastos, José Silva, Loide Barbosa, Jorge Polónia
OBJECTIVE: To assess ambulatory blood pressure monitoring (ABPM) circadian patterns and their determinants in a large sample of normotensive and hypertensive patients. METHODS: A total of 26170 individual ABPM recordings from 1995 to 2015 were analyzed. Mean office blood pressure (OBP), 24-hour blood pressure (BP), daytime BP and nocturnal BP were measured. Circadian patterns were classified by nocturnal systolic BP fall as extreme dipper (ED, ≥20%), dipper (D, 10%-19...
April 17, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29678482/verification-of-eye-lens-dose-in-imrt-by-mosfet-measurement
#19
Xuetao Wang, Guangjun Li, Jianling Zhao, Ying Song, Jianghong Xiao, Sen Bai
The eye lens is recognized as one of the most radiosensitive structures in the human body. The widespread use of intensity-modulated radiotherapy (IMRT) complicates dose verification and necessitates high standards of dose computation. The purpose of this work was to assess the computed dose accuracy of eye lens through measurements using a metal-oxide-semiconductor field-effect transistor (MOSFET) dosimetry system. Sixteen clinical IMRT plans of head and neck patients were copied to an anthropomorphic head phantom...
April 17, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29678058/building-a-knowledge-based-tool-for-auto-assessing-the-cardiovascular-risk
#20
Adrien Ugon, Amel Imene Hadj Bouzid, Marie-Christine Jaulent, Madeleine Favre, Catherine Duclos, Emmanuel Jobez, Hector Falcoff, Jean-Baptiste Lamy, Rosy Tsopra
The prevention of cardiovascular diseases needs first to quantify the cardiovascular risk. To estimate this risk, French national health authorities provided clinical practice guidelines extending the existing European SCORE, which doesn't include all the cardiovascular risk factors (e.g. diabetes). Hence, French national clinical practice guidelines to quantify the cardiovascular risk is able to deal with more clinical situations than the SCORE. The goal of this paper is to formalize knowledge extracted from these guidelines and implement the rules so that they can be used into an auto-assessing tool of cardiovascular risk...
2018: Studies in Health Technology and Informatics
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