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https://www.readbyqxmd.com/read/29031140/the-effects-of-real-and-artificial-leg-length-discrepancy-on-mechanical-work-and-energy-cost-during-the-gait
#1
T F Assogba, S Boulet, C Detrembleur, P Mahaudens
BACKGROUND: The impacts of Leg Length Discrepancy (LLD) on the kinematic and dynamic parameters of walking have been widely discussed. But little is known on total mechanical work and energy cost. These two variables are more representative of the functional impairment undergone by the LLD patients. AIM: To assess the changes of the mechanical work and energy cost of walking in subjects with real LLD and to compare their results with healthy subjects in whom the LLD has been simulated...
October 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29029354/cost-analysis-of-sending-routine-pathology-specimens-following-total-joint-arthroplasty-in-the-age-of-bundled-payments
#2
Hayden S Holbrook, Johannes F Plate, Maxwell K Langfitt, Jason E Lang, John S Shields
Bundled payment plans are being developed as a means to curb healthcare spending. Routine histology following total hip arthroplasties (THA) and total knee arthroplasties (TKA) is standard practice at many institutions. Recently, the value of this practice has been questioned as histologic diagnoses in THA and TKA rarely differ from the clinical diagnoses. The goal of this study is to identify discrepant and discordant diagnoses following THA and TKA at an academic medical center and to calculate the cost-saving potential in the setting of a bundled payment plan...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29029313/subjective-objective-sleep-discrepancy-is-associated-with-alterations-in-regional-glucose-metabolism-in-patients-with-insomnia-and-good-sleeper-controls
#3
Daniel B Kay, Helmet T Karim, Adriane M Soehner, Brant P Hasler, Jeffrey A James, Anne Germain, Martica H Hall, Peter L Franzen, Julie C Price, Eric A Nofzinger, Daniel J Buysse
Objectives: Sleep discrepancies are common in primary insomnia (PI), and include reports of longer sleep onset latency (SOL) than measured by polysomnography (PSG), or "negative SOL discrepancy." We hypothesized that negative SOL discrepancy in PI would be associated with higher relative glucose metabolism during non-rapid eye movement (NREM) sleep in brain networks involved in conscious awareness, including the salience, left executive control, and default mode networks. Methods: PI (n=32) and good sleeper controls (GS; n=30) completed [ 18F]fluorodeoxyglucose positron emission tomography (FDG-PET) scans during NREM sleep and relative regional cerebral metabolic rate for glucose (rCMRglc) was measured...
October 3, 2017: Sleep
https://www.readbyqxmd.com/read/29028385/computation-of-stability-regions-for-the-cylindrical-ion-trap-with-no-octupole-electric-field-as-compared-to-the-corresponding-results-of-the-paul-trap
#4
Houshyar Noshad, Majid Amouhashemi
The cylindrical ion trap is analyzed so that the octupole component of the electric field inside the trap is set to zero. As a consequence, the diameter to height ratio is computed to be 1.20 for which the quadrupole component of the cylindrical ion trap is dominant. Afterwards, it is concluded that the electric potential inside the trap as well as the corresponding stability regions are very similar to those obtained for an ideal Paul trap with pure quadrupole electric field. Furthermore, we drew a conclusion that the stability diagrams of the cylindrical ion trap without octupole term and the stability diagrams of the Paul trap have 5...
October 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028156/genetic-background-effects-in-neuroligin-3-mutant-mice-minimal-behavioral-abnormalities-on-c57-background
#5
Thomas C Jaramillo, Christine Ochoa Escamilla, Shunan Liu, Lauren Peca, Shari G Birnbaum, Craig M Powell
Neuroligin-3 (NLGN3) is a postsynaptic cell adhesion protein that interacts with presynaptic ligands including neurexin-1 (NRXN1) [Ichtchenko et al., Journal of Biological Chemistry, 271, 2676-2682, 1996]. Mice harboring a mutation in the NLGN3 gene (NL3R451C) mimicking a mutation found in two brothers with autism spectrum disorder (ASD) were previously generated and behaviorally phenotyped for autism-related behaviors. In these NL3R451C mice generated and tested on a hybrid C57BL6J/129S2/SvPasCrl background, we observed enhanced spatial memory and reduced social interaction [Tabuchi et al...
October 13, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29027838/the-role-of-appraisal-in-dysphoric-affect-reactivity-to-positive-laboratory-films-and-daily-life-events-in-depression
#6
Vanessa Panaite, Alana Whittington, Alexandra Cowden Hindash
Hedonic deficits are linked to protracted dysphoric affect (DA) in depression, a disorder characterised by emotion context insensitivity (ECI). Recent findings from daily life studies contradict the ECI view. This study longitudinally investigated DA across laboratory and daily life contexts and the conditions associated with discrepancies in DA reactivity. Thirty-three healthy controls and 41 adults with major depressive disorder (MDD) provided responses to neutral and positive (a) films viewed in the laboratory and (b) daily events recorded over the course of three days using ecological momentary assessment (EMA) methodology...
October 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29027633/multi-modality-imaging-in-the-evaluation-and-treatment-of-mitral-regurgitation
#7
REVIEW
Marc-André Bouchard, Claudia Côté-Laroche, Jonathan Beaudoin
Mitral regurgitation (MR) is frequent and associated with increased mortality and morbidity when severe. It may be caused by intrinsic valvular disease (primary MR) or ventricular deformation (secondary MR). Imaging has a critical role to document the severity, mechanism, and impact of MR on heart function as selected patients with MR may benefit from surgery whereas other will not. In patients planned for a surgical intervention, imaging is also important to select candidates for mitral valve (MV) repair over replacement and to predict surgical success...
October 13, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29027537/optimal-detection-of-clinically-relevant-mutations-in-colorectal-carcinoma-sample-pooling-overcomes-intra-tumoral-heterogeneity
#8
Andrew C Nelson, Jamie Boone, David Cartwright, Bharat Thyagarajan, Robyn Kincaid, Aaron P Lambert, Kylene Karnuth, Christine Henzler, Sophia Yohe
Intra-tumoral genomic heterogeneity is a well-established biologic property of human malignancies with emerging roles in cancer progression and therapy resistance. However, its impact on the clinical utility of genomic testing in patient management remains unclear. Furthermore, best practices to account for heterogeneity in the provision of highly accurate, clinically valid molecular testing have yet to be firmly established. Genomic biomarkers for the management of colorectal carcinoma are both well-established (ie, KRAS, NRAS) and emerging (BRAF, PIK3CA, and others) in respect to therapy selection and clinical trial eligibility...
October 13, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29027184/low-rate-of-clinically-important-avascular-necrosis-of-the-femoral-head-after-ludloff-s-procedure
#9
Jesper Holbeck-Brendel, Bjarne Møller-Madsen, Ivan Hvid, Michel B Hellfritzsch, Line K Pedersen, Peter Dalsgaard, Ole Rahbek
INTRODUCTION: Ludloff's procedure for open reduction of congenital dislocation of the hip (CDH) is recommended for its minimal tissue damage, but is criticised for the risk of late avascular necrosis (AVN) of the femoral head. The aim of present study was primarily to assess the risk of late AVN of the femoral head and secondly the range of motion (ROM) of the hip and the quality of life in children following Ludloff's procedure. METHODS AND MATERIALS: 13 hips in 11 children after Ludloff's procedure due to CDH were included retrospectively from 1997 to 2005 at Aarhus University Hospital...
October 12, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29027181/excellent-inter-observer-agreement-between-radiologist-and-nurse-tracheal-carina-based-identification-of-peripherally-inserted-central-catheter-tip-position
#10
Xiaoxia Zhang, Dan Jia, Nengwen Ke, Chang Liu, Lan Fu, Xiuying Hu
INTRODUCTION: Accurate identification of position of a central venous catheter tip is important to reduce catheter-related complications. Nevertheless, inter-observer bias limits the accuracy of traditional method for determining tip position on chest x-ray (CXR) images. The aim of this study was to explore a simple and objective method for assessing position of peripherally inserted central catheter (PICC) tip on CXR image. METHODS: Tracheal carina was used as the landmark to identify positions of catheter tips...
October 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29027030/diagnostic-accuracy-of-fungal-identification-in-histopathology-and-cytopathology-specimens
#11
V L Kung, R D Chernock, C-A D Burnham
Tools to diagnose fungal infection are microscopic examination, antigen or antibody-based detection tests, molecular diagnostics, and culture, with culture being the "gold standard" for species-level identification. Although these methods are commonly used in concert and yield concordant results, in some cases tissue is not available for culture, and/or different methodologies yield discrepant results. These discrepancies may be clinically significant, causing confusion and inappropriate or delayed initiation of antifungals...
October 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29026807/airway-management-in-pierre-robin-sequence-the-vancouver-classification
#12
Wai-Yee Li, Alana Poon, Douglas Courtemanche, Cynthia Verchere, Sandra Robertson, Marija Bucevska, Claudia Malic, Jugpal S Arneja
BACKGROUND: Pierre Robin sequence (PRS) is a triad of micrognathia, glossoptosis, and respiratory distress. There is no standard clinical classification used in the management of neonatal airway in patients with PRS. The goal of our study was to review the presentation and management of patients with PRS and formulate a clinical grading system and treatment algorithm. METHODS: A 10-year retrospective review of all neonates diagnosed with PRS was performed after obtaining institutional ethics approval...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026754/medication-discrepancies-and-potentially-inadequate-prescriptions-in-elderly-adults-with-polypharmacy-in-ambulatory-care
#13
Juan Víctor Ariel Franco, Sergio Adrián Terrasa, Karin Silvana Kopitowski
OBJECTIVES: The objective of this study is to describe the frequency and type of medication discrepancies (MD) through medication reconciliation and to describe the frequency of potentially inadequate prescription (PIP) medications using screening tool of older persons' prescriptions criteria. DESIGN: Cross-sectional comparison of electronic medical record (EMR) medication lists and patient's self-report of their comprehensive medication histories obtained through telephone interviews...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026355/colistin-and-polymyxin-b-minimal-inhibitory-concentrations-determined-by-etest-found-unreliable-for-gram-negative-bacilli
#14
Shelby Simar, Diane Sibley, Deborah Ashcraft, George Pankey
BACKGROUND: A reliable method of polymyxin B and E (colistin) susceptibility testing remains elusive. These drugs diffuse poorly into agar, creating potentially inaccurate Etest and disk diffusion results, and testing by these methods is not recommended. Broth microdilution is the reference testing method, although it can be sometimes difficult to interpret. Currently, when a colistin susceptibility test is ordered for a patient in the Ochsner Health System, our diagnostic microbiology laboratory performs the Etest...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29026275/a-case-of-45-x-47-xxx-mosaic-turner-syndrome-with-limb-length-discrepancy
#15
Nozomi Hishimura-Yonemaru, Koji Okuhara, Nobuhiro Takahashi, Hidefumi Tonoki, Susumu Iizuka, Toshihiro Tajima
Patients with Turner syndrome (TS) frequently show short stature and skeletal deformities, such as kyphosis and scoliosis. However, to the best of our knowledge, limb length discrepancy (LLD) has not yet been reported in patients with TS. The case of a 12-yr-old girl with 45,X/47,XXX mosaic TS showing LLD is herein presented. She was on GH therapy for short stature and was noted to have scoliosis in the standing position at a regular examination; however, the scoliosis became less evident in the supine position, which is indicative of LLD...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29026168/gene-losses-and-partial-deletion-of-small-single-copy-regions-of-the-chloroplast-genomes-of-two-hemiparasitic-taxillus-species
#16
Ying Li, Jian-Guo Zhou, Xin-Lian Chen, Ying-Xian Cui, Zhi-Chao Xu, Yong-Hua Li, Jing-Yuan Song, Bao-Zhong Duan, Hui Yao
Numerous variations are known to occur in the chloroplast genomes of parasitic plants. We determined the complete chloroplast genome sequences of two hemiparasitic species, Taxillus chinensis and T. sutchuenensis, using Illumina and PacBio sequencing technologies. These species are the first members of the family Loranthaceae to be sequenced. The complete chloroplast genomes of T. chinensis and T. sutchuenensis comprise circular 121,363 and 122,562 bp-long molecules with quadripartite structures, respectively...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025915/rl-skat-an-exact-and-efficient-score-test-for-heritability-and-set-tests
#17
Regev Schweiger, Omer Weissbrod, Elior Rahmani, Martina Müller-Nurasyid, Sonja Kunze, Christian Gieger, Melanie Waldenberger, Saharon Rosset, Eran Halperin
Testing for the existence of variance components in linear mixed models is a fundamental task in many applicative fields. In statistical genetics, the score test has recently become instrumental in the task of testing an association between a set of genetic markers and a phenotype. With few markers, this amounts to set-based variance component tests, which attempt to increase power in association studies by aggregating weak individual effects. When the entire genome is considered, it allows testing for the heritability of a phenotype, defined as the proportion of phenotypic variance explained by genetics...
October 12, 2017: Genetics
https://www.readbyqxmd.com/read/29025842/discrepancies-between-clinicaltrials-gov-recruitment-status-and-actual-trial-status-a-cross-sectional-analysis
#18
Christopher W Jones, Michelle R Safferman, Amanda C Adams, Timothy F Platts-Mills
OBJECTIVES: To determine the accuracy of the recruitment status listed on ClinicalTrials.gov as compared with the actual trial status. DESIGN: Cross-sectional analysis. SETTING: Random sample of interventional phase 2-4 clinical trials registered between 2010 and 2012 on ClinicalTrials.gov. PRIMARY OUTCOME MEASURE: For each trial which was listed within ClinicalTrials.gov as ongoing, two investigators performed a comprehensive literature search for evidence that the trial had actually been completed...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025833/prevalence-and-incidence-of-hypertension-in-the-global-hiv-infected-population-a-systematic-review-and-meta-analysis-protocol
#19
Jean Joel Bigna, Aurel T Tankeu, Arnaud D Kaze, Jean Jacques Noubiap, Jobert Richie Nansseu
INTRODUCTION: Hypertension, representing one of the most frequent cardiovascular risk factors, is thought to increase in individuals living with HIV as well as in general population, but summarised global data on the topic are scarce. We conduct this systematic review and meta-analysis to assess the prevalence/incidence of hypertension in the global HIV-infected population. METHODS AND ANALYSIS: This review will include observational studies conducted among HIV-infected people, which reported prevalence/incidence of hypertension or enough data for its appraisal...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025508/discrepancy-in-motivation-for-weight-loss-and-exercise-in-rural-patients
#20
Jacob C Warren, K Bryant Smalley, K Nikki Barefoot
OBJECTIVES: We explored the extent to which discrepancy between motivation for weight loss and exercise is related to obesity among rural patients with chronic disease, and identified the psychosocial correlates of this discrepancy. METHODS: 497 patients with diabetes and/or hypertension were recruited from a network of Federally Qualified Health Centers in the rural South and completed a battery of assessments. RESULTS: Most persons in the sample (83...
November 1, 2017: American Journal of Health Behavior
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