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Luminita N Cima, Sorina C Martin, Ioana M Lambrescu, Lavinia Stejereanu, Cristina Zaharia, Anca Colita, Simona Fica
BACKGROUND: Thyroid dysfunction (TD) was usually described in hematopoietic stem cell transplantation (HSCT) recipients who were given total body irradiation (TBI) in the conditioning regimen. Because previous studies have reported discrepant results regarding the presence of long-term thyroid complications in HSCT survivors following chemotherapy-only conditioning, we investigated the frequency of thyroid abnormalities in a series of children treated with HSCT for different disorders without TBI as part of the conditioning protocol...
June 23, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Zahra Karimian, Fatemeh Atoof, Seyed Ali Azin, Raziyeh Maasoumi, Effat Merghati Khoei
BACHGROUND: Women's sexual well-being has been the center of attention in the field of sexology. Study of sexual behavior and investigating its predictors are important for women's health promotion. This study aimed to explore the components of women's sexual behaviors and their possible associations with demographic variables. MATERIALS AND METHODS: This study was a cross-sectional study (descriptive and analytic) that was conducted in Kashan city, Iran. A National Sexual Behavior Assessment Questionnaire was completed by 500 women of 15 to 49 who referred to the public health centers...
June 2018: International Journal of Fertility & Sterility
Anthony C Legon, Dmitry Sharapa, Timothy Clark
High-level ab initio calculations on the complexes between noble gas atoms (He, Ne, Ar, Kr, and Xe) and dihalogen molecules (F2 , Cl2 , Br2 , and I2 ) reveal trends, both in interaction energies and the energy difference between the linear and T-shaped structures, that can be explained well in terms of dispersion interactions enhanced by polar flattening of the halogens. The partial discrepancies with experimental findings are discussed. Graphical abstract The molecular electrostatic potential (red positive, blue negative) of Cl2 ...
June 22, 2018: Journal of Molecular Modeling
Cesare Granata, Nicholas A Jamnick, David J Bishop
A sedentary lifestyle has been linked to a number of metabolic disorders that have been associated with sub-optimal mitochondrial characteristics and an increased risk of premature death. Endurance training can induce an increase in mitochondrial content and/or mitochondrial functional qualities, which are associated with improved health and well-being and longer life expectancy. It is therefore important to better define how manipulating key parameters of an endurance training intervention can influence the content and functionality of the mitochondrial pool...
June 22, 2018: Sports Medicine
Mohammad J Tahmasebi Birgani, Maziyar Mahdavi, Mansour Zabihzadeh, Mehrzad Lotfi, Mohammad A Mosleh-Shirazi
Relative electron densities of body tissues (ρe ) for radiotherapy treatment planning are normally obtained by CT scanning of tissue substitute materials (TSMs) and producing a Hounsfield Unit-ρe calibration curve. Aiming for more accurate, simultaneous characterization of ρe and effective atomic number (Zeff ) of real tissues, an in-house phantom (including 10 water solutions plus composite cork as TSMs) was constructed and scanned at 4 kVps. Dual-energy algorithms were applied to 80-140 and 100-140 kVp combination scans, for better differentiation of tissues with same attenuation coefficient at 120 kVp but different ρe and Zeff ...
June 22, 2018: Australasian Physical & Engineering Sciences in Medicine
Dmitry Y Borzunov, Alexander L Shastov
INTRODUCTION: Ilizarov bone transport for large bone defect is challenging and may end in distraction osteogenesis failure. MATERIAL AND METHODS: Ten forearm and seven tibial defect cases with failed regeneration due to ischaemia during bone transport were studied retrospectively. Mean forearm and tibial defects were 5.5 ± 0.8 and 7.6 ± 1 cm respectively, or 22.3 ± 3.6 and 20 ± 2.3% as compared with healthy segments. Most patients had numerous previous operations (2...
June 23, 2018: International Orthopaedics
Susana Patrícia Lopes, Nuno Filipe Azevedo, Maria Olívia Pereira
Selecting appropriate tools providing reliable quantitative measures of individual populations in biofilms is critical as we now recognize their true polymicrobial and heterogeneous nature. Here, plate count, quantitative real-time polymerase chain reaction (q-PCR) and peptide nucleic acid probe-fluorescence in situ hybridization (PNA-FISH) were employed to quantitate cystic fibrosis multispecies biofilms. Growth of Pseudomonas aeruginosa, Inquilinus limosus and Dolosigranulum pigrum was assessed in dual- and triple-species consortia under oxygen and antibiotic stress...
June 22, 2018: Scientific Reports
Caitlin W Brown, John J Amante, Arthur M Mercurio
Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of lipid-targeting reactive oxygen species that kill cells by damaging their plasma membrane. The lipid-repair enzyme glutathione peroxidase 4 (GPX4) protects against this oxidative damage and enables cells to resist ferroptosis. Recent work has revealed that matrix-detached carcinoma cells can be susceptible to ferroptosis and that they can evade this fate through the signaling properties of the α6β4 integrin, which sustains GPX4 expression...
June 22, 2018: Journal of Biological Chemistry
Jinhong Jung, Hojin Kim, Sang Min Yoon, Byungchul Cho, Yeon Joo Kim, Jungwon Kwak, Jong Hoon Kim
PURPOSE: Stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) has emerged as an alternative treatment option when curative treatment modalities cannot be applied. Although excellent local tumor control has been achieved with SBRT, the targeting accuracy in real-life practice remains poorly understood. We proposed an in vivo assessment of targeting accuracy using hepatic parenchymal changes observed on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) images and applied this method to investigate the "real-life" targeting accuracy of image-guided SBRT...
May 14, 2018: International Journal of Radiation Oncology, Biology, Physics
Tang-Huang Lin, Min-Chung Hsiao, Hai-Po Chan, Fuan Tsai
Radiometric calibration for imaging sensors is a crucial procedure to ensure imagery quality. One of the challenges in relative radiometric calibration is to correct detector-level artifacts due to the fluctuation in discrepant responses (spatial) and electronic instability (temporal). In this paper, the integration of the empirical mode decomposition (EMD) with Hilbert⁻Huang transform (HHT) in relative radiometric calibration was explored for a new sensor, FS-5 RSI (remote sensing instrument onboard the FORMOSAT-5 satellite)...
June 21, 2018: Sensors
Hiroki Kano, Yohei Matsuo, Noriaki Kubo, Satoshi Fujimi, Takashi Nishiii
STUDY DESIGN: This was a retrospective case series at a single institution. OBJECTIVE: The study was performed to investigate the characteristics of spinal injuries in survivors of suicidal jumping. SUMMARY OF BACKGROUND DATA: Spinal fracture/dislocation is associated with high-energy trauma such as that induced by motor vehicle accidents. Survivors of suicidal jumping sometimes sustain spinal injuries. However, the characteristics of such spinal injuries are unclear...
June 21, 2018: Spine
Judith M Graber, Connie T Chuang, Carolyn L Ward, Kathleen Black, Iris G Udasin
OBJECTIVE: To report on cases of head and neck cancer (HNC) among World Trade Center (WTC) responders participating in the WTC Health Program and seen at Rutgers WTC Center of Clinical Excellence. METHODS: Medical records were abstracted by two clinical reviewers and discrepancies resolved. Cases were defined as WTC responders diagnosed with HNC between 9/12/2005 and 12/31/2016. RESULTS: Sixteen HNC patients met the case definition, most (13) arrived at the WTC location on 9/11 or within the following 2 days and half worked in law enforcement during the 9/1 response...
June 21, 2018: Journal of Occupational and Environmental Medicine
Philip Huang, Mary Elizabeth Lundgren, Rajeev Garapati
Complete talar extrusion is rare and usually associated with a high-energy mechanism of injury causing complete dissociation of the talus from the surrounding bony and soft-tissue structures with enough force to expel the talus out of the body. Treatment can be complicated by infection, osteonecrosis, posttraumatic osteoarthritis, and leg length discrepancy, which may require multiple subsequent surgeries for improved outcome and quality of life. Reimplantation of the native talus affords maintenance of joint height and favorable outcomes have been reported...
June 21, 2018: Journal of the American Academy of Orthopaedic Surgeons
Stefanie R van Mil, Guy H E J Vijgen, Astrid van Huisstede, Boudewijn Klop, Gert-Jan M van de Geijn, Erwin Birnie, Gert-Jan Braunstahl, Guido H H Mannaerts, L Ulas Biter, Manuel Castro Cabezas
BACKGROUND: Obesity is related to increased cardiovascular risk. It is unknown whether increasing levels of obesity also increase levels of cardiovascular risk factors and systemic inflammation. This study describes the relationship between classic cardiovascular risk factors and inflammatory markers with BMI in a group of obese and non-obese subjects. MATERIALS AND METHODS: Obese subjects (BMI ≥ 30 kg/m2 ; n = 576; mean ± SD BMI 43.8 ± 7.58 kg/m2 ) scheduled for bariatric surgery were included...
June 21, 2018: Obesity Surgery
Ritu R Gill, Beow Y Yeap, Raphael Bueno, William G Richards
Background: Analysis of the International Association for the Study of Lung Cancer (IASLC) Malignant Pleural Mesothelioma (MPM) database revealed that clinical (cTNM) staging minimally stratified survival and was discrepant with pathological (pTNM) staging. To improve prognostic classification of MPM, alternative staging models based on quantitative parameters were explored. Methods: An institutional review board-approved MPM registry was queried to identify patients with available pathological and preoperative imaging data...
March 1, 2018: Journal of the National Cancer Institute
Estefanía Aranda Yus, Josep Maria Anglada Cantarell, Antonio Miñarro Alonso
PURPOSE: To determine the discrepancy in monolithic zirconium dioxide crowns made with computer-aided design and computer-aided manufacturing (CAD/CAM) systems by comparing scans of silicone impressions and of master casts. MATERIALS AND METHODS: From a Cr-Co master die of a first upper left molar, 30 silicone impressions were taken. The 30 silicone impressions were scanned with the laboratory scanner, thus obtaining 30 milled monolithic yttrium stabilized zirconium dioxide (YSZD) crowns (the silicone group)...
June 2018: Journal of Advanced Prosthodontics
Timothy Tapscott, Ju-Sim Kim, Matthew A Crawford, Liam Fitzsimmons, Lin Liu, Jessica Jones-Carson, Andrés Vázquez-Torres
The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regulatory gene ssrA plays a distinct role in the balanced expression of the Salmonella pathogenicity island-2 (SPI2) type III secretion system. The RNA polymerase-binding protein DksA activates the ssrAB regulon post-transcriptionally, whereas the alarmone guanosine tetraphosphate (ppGpp) relieves the negative regulation imposed by the AT-rich ssrA discriminator region...
June 21, 2018: Scientific Reports
V Favier, C Vincent, É Bizaguet, D Bouccara, R Dauman, B Frachet, F Le Her, C Meyer-Bisch, S Tronche, F Sterkers-Artières, F Venail
INTRODUCTION: French Society of ENT (SFORL) good practice guidelines for audiometric examination in adults and children. METHODS: A multidisciplinary working group performed a review of the scientific literature. Guidelines were drawn up, reviewed by an independent reading group, and finalized in a consensus meeting. RESULTS: Audiometry should be performed in an acoustically controlled environment (<30dBA); audiometer calibration should be regularly checked; and patient-specific masking rules should be systematically applied...
June 18, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Jiayin Diao, Can Xu, Huiting Zheng, Siyi He, Shumei Wang
Viticis Fructus is a traditional Chinese herbal drug processed by various methods to achieve different clinical purposes. Thermal treatment potentially alters chemical composition, which may impact on effectiveness and toxicity. In order to interpret the constituent discrepancies of raw versus processed (stir-fried) Viticis Fructus, a multivariate detection method (NIR, HPLC, and UPLC-MS) based on metabonomics and chemometrics was developed. Firstly, synergy interval partial least squares and partial least squares-discriminant analysis were employed to screen the distinctive wavebands (4319 - 5459 cm-1 ) based on preprocessed near-infrared spectra...
June 21, 2018: Planta Medica
Junyu Zhao, Chunmei Xu, Jinming Yao, Changzhen Yu, Lin Liao, Jianjun Dong
BACKGROUND/AIMS: Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence. METHODS: Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries- were searched...
June 19, 2018: Cellular Physiology and Biochemistry
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