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management of type 2 diabetes mellitus

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https://www.readbyqxmd.com/read/29679303/do-the-sglt-2-inhibitors-offer-more-than-hypoglycemic-activity
#1
REVIEW
Eduardo Flores, Carlos G Santos-Gallego, Nely Diaz-Mejía, Juan Jose Badimon
Type 2 diabetes mellitus (T2DM) is one of the most common chronic health conditions in the USA; it affects approximately 10% of adults with up to one-quarter being undiagnosed. T2DM is associated with substantial cardiovascular (CV) morbidity and mortality. T2DM is a pathological condition characterized by elevated levels of glucose and associated with high CV risk. Traditional hypoglycemic drugs have demonstrated their capability for effective and maintained management of high glucose levels, but they have not significantly impacted on the incidence of CV events...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29678605/hypoglycemia-in-type-2-dm-patients-review-article
#2
REVIEW
Ayla M Tourkmani, Turki J Alharbi, Abdulaziz M Bin Rsheed, Abdulrhamn N AlRasheed, Saad M AlBattal, Osama Abdelhay, Mohamed A Hassali, Alian A Alrasheedy, Nouf G Al Harbi, Abdulaziz Alqahtani
Hypoglycemia is an essential issue for diabetic patients and considered a limiting factor in the glycemic management. Heterogeneity of the diseases in Type 2 Diabetes Mellitus can affect the frequency of hypoglycemia, especially when the patient has cardiovascular diseases. There are several factors lead to hypoglycemia sulfonylurea therapy, insulin therapy, delayed or missed a meal, physical exercise, or drug or alcohol consumption. Long-term studies reported that repeated hypoglycemia is increasing the risk of cardiovascular disease...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#3
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676545/hemorheologic-alterations-in-patients-with-type-2-diabetes-mellitus-presented-with-an-acute-myocardial-infarction
#4
Kyu Hwan Park, Ung Kim, Kang Un Choi, Jong Ho Nam, Jung Hee Lee, Chan Hee Lee, Jang Won Son, Jong Seon Park, Dong Gu Shin, Kyu Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang Soo Suh
BACKGROUND: Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676539/past-and-current-status-of-adult-type-2-diabetes-mellitus-management-in-korea-a-national-health-insurance-service-database-analysis
#5
REVIEW
Seung Hyun Ko, Kyungdo Han, Yong Ho Lee, Junghyun Noh, Cheol Young Park, Dae Jung Kim, Chang Hee Jung, Ki Up Lee, Kyung Soo Ko
Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29674306/diabeo-app-software-and-telemedicine-versus-usual-follow-up-in-the-treatment-of-diabetic-patients-protocol-for-the-telesage-randomized-controlled-trial
#6
Nathalie Jeandidier, Lucy Chaillous, Sylvia Franc, Pierre-Yves Benhamou, Pauline Schaepelynck, Hélène Hanaire, Bogdan Catargi, Anne Farret, Pierre Fontaine, Bruno Guerci, Yves Reznik, Alfred Penfornis, Sophie Borot, Pierre Serusclat, Yacine Kherbachi, Geneviève D'Orsay, Bruno Detournay, Pierre Simon, Guillaume Charpentier
BACKGROUND: Self-management of diabetes minimizes the risk of macrovascular and microvascular complications, but understanding and/or adherence to self-management recommendations is often suboptimal. DIABEO is a smartphone app (downloaded via the internet) used to calculate bolus insulin doses. A previous study (TELEDIAB 1) showed that the use of DIABEO was associated with a significant improvement in glycemic control in patients with poorly controlled type 1 diabetes mellitus, particularly when combined with teleconsultations with physicians...
April 19, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29673847/challenges-in-the-management-of-type-2-diabetes-among-native-women-in-the-united-arab-emirates
#7
Walaa Abuelmagd, Bachar Afandi, Helle Håkonsen, Seham Khmidi, Else-Lydia Toverud
AIM: To investigate type 2 diabetes mellitus (T2DM) management in native female patients in the United Arab Emirates (UAE). METHODS: Ninety women from the outpatient diabetes clinic at Tawam Hospital, UAE, were interviewed face-to-face using a structured questionnaire. Glycated hemoglobin (HbA1c), blood pressure, lipid panel, weight and body mass index (BMI) were extracted from medical records. RESULTS: Mean age was 57.5 (SD:12.7) years. Forty-five participants (50...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29672567/costs-and-effectiveness-of-pharmacist-led-group-medical-visits-for-type-2-diabetes-a-multi-center-randomized-controlled-trial
#8
Wen-Chih Wu, Tracey H Taveira, Sean Jeffery, Lan Jiang, Lisa Tokuda, Joanna Musial, Lisa B Cohen, Fred Uhrle
OBJECTIVES: The effectiveness and costs associated with addition of pharmacist-led group medical visits to standard care for patients with Type-2 Diabetes Mellitus (T2DM) is unknown. METHODS: Randomized-controlled-trial in three US Veteran Health Administration (VHA) Hospitals, where 250 patients with T2DM, HbA1c >7% and either hypertension, active smoking or hyperlipidemia were randomized to either (1) addition of pharmacist-led group-medical-visits or (2) standard care alone for 13 months...
2018: PloS One
https://www.readbyqxmd.com/read/29670330/the-efficacy-and-safety-of-ginkgo-biloba-extract-as-an-adjuvant-in-type-2-diabetes-mellitus-patients-ineffectively-managed-with-metformin-a-double-blind-randomized-placebo-controlled-trial
#9
Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Heshu Sulaiman Rahman, Abdullah Rasedee
Background and aim: Type 2 diabetes mellitus (T2DM) is one of the major diseases confronting the health care systems. In diabetes mellitus (DM), combined use of oral hypoglycemic medications has been shown to be more effective than metformin (Met) alone in glycemic control. This study determined the effects of Ginkgo biloba (GKB) extract as an adjuvant to Met in patients with uncontrolled T2DM. Subjects and methods: Sixty T2DM patients were recruited in a randomized, placebo-controlled, double-blinded, and multicenter trial...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29669452/association-between-provider-specialty-and-healthcare-costs-and-glycemic-control-for-patients-with-diabetes
#10
Max Gill, Harmeet Chhabra, Mona Shah, Cyrus Zhu, Howard Lando, Felice Caldarella
AIMS: To analyze the association between provider, healthcare costs, and glycemic control for patients with diabetes mellitus (DM). MATERIALS AND METHODS: This cross-sectional study identified adults with type 1 or 2 DM (T1D, T2D) in the Optum database. The main independent variable was provider (endocrinologist or primary care). Regression analysis compared total medical and pharmacy costs, adjusting for health status and other patient differences, by provider...
April 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29668928/akkermansia-muciniphila-can-reduce-the-damage-of-gluco-lipotoxicity-oxidative-stress-and-inflammation-and-normalize-intestine-microbiota-in-streptozotocin-induced-diabetic-rats
#11
Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, Guoqing Wang
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects Akkermansia muciniphila on type 2 diabetes mellitus. Normal and streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with Akkermansia muciniphila and solvent. After four weeks of treatment, diabetic rats orally administered with live or pasteurized Akkermansia muciniphila exhibited significant increase in the blood concentration of high-density lipoprotein, and decrease in the hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide, malondialdehyde, and total glucagon-like peptide-1...
April 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#12
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29666033/antidiabetics-usage-in-type-2-diabetes-mellitus-are-prescribing-guidelines-adhered-to-a-single-centre-study
#13
Viviane Khalil, Christy Sajan, Tiffany Tsai, David Ma
AIM: The primary aim of this study was to examine the prescribing patterns of antidiabetic agents (AA) in this hospital according to current prescribing contraindications (PCI). The secondary aims are to assess factors affecting the prescribing of AA and to evaluate the pharmacist impact on their prescribing. METHOD: A retrospective cross sectional study was performed to review all prescribed AA over a 3 month period. Data extracted from medical records included: patients' demographics, management and pharmacists' interventions...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29665584/-is-there-an-association-between-dmp-enrollment-and-disability-pension-in-rehabilitants-with-type-2-diabetes
#14
Christian Schmidt, Bernd Hagen, Jens Baumert, Thomas Ziese
Efficacy of treatment of working-age patients with diabetes mellitus can be increased by rehabilitative measures. This treatment option is explicitly mentioned in the guidelines of the disease management program (DMP) for type 2 diabetes (T2D). With research data from the pension insurance fund, it is shown that for rehabilitation patients with T2D and DMP enrolment, the chance of disability pension is 23% lower than without DMP enrolment, irrespective of relevant covariates.
April 17, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#15
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29663879/anti-cancer-effects-of-metformin-recent-evidences-for-its-role-in-prevention-and-treatment-of-cancer
#16
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Warda Kamal, Mohammad A Kamal
Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyperinsulinemia, and Insulin-like growth factor 1 (IGF-1) level was considered its indirect effects...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29663262/characteristics-treatment-patterns-and-economic-outcomes-of-patients-initiating-injectable-medications-for-management-of-type-2-diabetes-mellitus-in-japan-results-from-a-retrospective-claims-database-analysis
#17
Shuichi Suzuki, Urvi Desai, Alena Strizek, Jasmina Ivanova, Viviana Garcia-Horton, Zhihong Cai, Luke Schmerold, Xinyue Liu, Magaly Perez-Nieves
INTRODUCTION: This study's objective was to describe characteristics, treatment patterns, and economic outcomes of type 2 diabetes mellitus (T2DM) patients initiating injectable antidiabetic medications in Japan. METHODS: Adults (≥ 18 years) with T2DM, ≥ 2 claims for injectable antidiabetics between 1 August 2011 and 31 July 2015 (first claim = index date), no evidence of type 1 diabetes mellitus, ≤ 1 claim for insulin, no claims for GLP-1RA before index, and continuous enrollment for 6 months before (baseline) and 12 months after index (follow-up) were selected from the Japan Medical Center Database...
April 16, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29661086/consequences-of-non-medical-switch-among-patients-with-type-2-diabetes
#18
Natalia M Flores, Charmi A Patel, Brahim K Bookhart, Shaffeeulah Bacchus
OBJECTIVE: This study aimed to describe real-world experiences following a non-medical switch among adults with type 2 diabetes mellitus (T2DM) in the United States. METHODS: For this cross-sectional study, patients with T2DM (N = 451) provided data on demographics and how a non-medical switch of their anti-hyperglycemic agent (AHA) affected their general health, HbA1c levels, and medication management via an Internet-based survey. Patients self-reported their level of satisfaction with the original medication and emotional reactions to the non-medical switch...
April 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29658286/personal-health-coaching-as-a-type-2-diabetes-mellitus-self-management-strategy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Meysam Pirbaglou, Joel Katz, Mehras Motamed, Sarah Pludwinski, Krista Walker, Paul Ritvo
OBJECTIVE: Personal health coaching (PHC) programs have become increasingly utilized as a type 2 diabetes mellitus (T2DM) self-management intervention strategy. This article evaluates the impact of PHC programs on glycemic management and related psychological outcomes. DATA SOURCES: Electronic databases (CINAHL, MEDLINE, PubMed, PsycINFO, and Web of Science). STUDY INCLUSION AND EXCLUSION CRITERIA: Randomized controlled trials (RCT) published between January 1990 and September 2017 and focused on the effectiveness of PHC interventions in adults with T2DM...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29650028/a-rare-presentation-of-pulmonary-sarcoidosis-as-a-solitary-lung-mass-a-case-report
#20
Dylan W Kelleher, Madeleine Yaggi, Robert Homer, Erica L Herzog, Changwan Ryu
BACKGROUND: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy...
April 13, 2018: Journal of Medical Case Reports
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