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management of type 2 diabetes mellitus

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https://www.readbyqxmd.com/read/29243325/camp-based-multi-component-intervention-for-families-of-young-children-with-type-1-diabetes-a-pilot-and-feasibility-study
#1
Olga T Gupta, Marsha MacKenzie, Angie Burris, Bonnie B Jenkins, Nikki Collins, Molly Shade, Eileen Santa-Sosa, Sunita M Stewart, Perrin C White
BACKGROUND: Managing type 1 diabetes mellitus (T1DM) in preschool-aged children has unique challenges that can negatively impact glycemic control and parental coping. OBJECTIVE: To evaluate the impact of a camp-based multi-component intervention on glycated hemoglobin A1c (HbA1c) in young children with T1DM and psychosocial measures for their parents. SUBJECTS AND METHODS: Two separate cohorts of 18 children (ages 3-5 years) and their families participated in a camp-based intervention that included didactic and interactive parent education, child-centered education and family-based recreational activities...
December 15, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29241389/euglycemic-diabetic-ketoacidosis-associated-with-sodium-glucose-cotransporter-type-2-inhibitors-in-patients-with-type-2-diabetes-mellitus-receiving-oral-therapy
#2
Ryan B Dull, Mikayla L Spangler, Emily L Knezevich, Britney M Lau
INTRODUCTION AND OBJECTIVE: Postmarketing reports and warnings of serious adverse events such as diabetic ketoacidosis (DKA) have raised concern regarding the safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i). This report describes 2 cases of symptomatic SGLT2i-associated euglycemic DKA (euDKA) leading to hospitalization in patients with type 2 diabetes mellitus (DM) previously well controlled on oral medications. CASE REPORTS: Subject 1 is a 55-year-old female admitted with euDKA precipitated by infection and managed with intravenous insulin...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29241374/pharmacokinetic-drug-evaluation-of-empagliflozin-plus-linagliptin-for-the-treatment-of-type-2-diabetes
#3
C V Rizos, T D Filippatos, M S Elisaf
Type 2 diabetes mellitus has become a growing epidemic and therefore efficient treatment strategies that target its management are needed. The treatment of diabetic patients often requires the combination of antidiabetic drug classes. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) block glucose reabsorption in the proximal renal tubules. Dipeptidyl peptidase-4 inhibitors (DPP-4i) improve glucose metabolism by blocking the enzyme that degrades incretins leading to increased insulin secretion. Areas covered: The aim of the review is to present the available data on pharmacokinetic properties/pharmacodynamics, metabolic and cardiovascular effects...
December 15, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29238240/the-effect-of-dpp-4-inhibitors-on-asthma-control-an-administrative-database-study-to-evaluate-a-potential-pathophysiological-relationship
#4
Gene Colice, David Price, Maria Gerhardsson de Verdier, Karma Rabon-Stith, Christopher Ambrose, Katherine Cappell, Debra E Irwin, Paul Juneau, Anna Vlahiotis
Rationale: DPP-4 may regulate immunological pathways implicated in asthma. Assessing whether DPP-4 inhibitor (DPP-4i) use might affect asthma control is clinically important because DPP-4i use in type 2 diabetes mellitus management (T2DM) is increasing. This study evaluated associations between DPP-4i use and asthma control. Methods: This was a retrospective, observational, matched cohort study using administrative claims in the MarketScan® Commercial Claims and Encounters (Commercial) and Medicare Supplemental and Coordination of Benefits (Medicare Supplemental) databases...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29238004/frailty-in-elderly-diabetes-patients
#5
Toshihiko Yanase, Ikumi Yanagita, Kazuo Muta, Hajime Nawata
Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/frailty...
December 14, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29234435/baduanjin-exercise-for-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Junmao Wen, Tong Lin, Yinhe Cai, Qianying Chen, Yuexuan Chen, Yueyi Ren, Senhui Weng, Boqing Wang, Shuliang Ji, Wei Wu
Objective: To investigate the effects of Baduanjin exercise for type 2 diabetes mellitus. Methods: Literature retrieval was performed in several databases, including PubMed, EMBASE, Cochrane Library, CNKI, Wanfang Data Information Site, CBM, and VIP from inception to April 2017. Randomized controlled trials on evaluating the effects of Baduanjin exercise were identified. The primary outcomes were glycosylated hemoglobin, fasting blood-glucose, and postprandial plasma glucose...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230803/peri-operative-management-of-patients-with-type-2-diabetes-mellitus-undergoing-non-cardiac-surgery-using-liraglutide-glucose-insulin-potassium-infusion-or-intravenous-insulin-bolus-regimens-a-randomised-controlled-trial
#7
J A W Polderman, S C J van Steen, B Thiel, M B Godfried, P L Houweling, M W Hollmann, J H DeVries, B Preckel, J Hermanides
In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery. Patients were randomly allocated using a web-based randomisation program to premedication with liraglutide (liraglutide group), glucose-insulin-potassium infusion (insulin infusion group) or insulin bolus regimen (insulin bolus group), targeting a glucose < 8...
December 12, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29228855/effects-of-telephone-call-intervention-on-cardiovascular-risk-factors-in-type-2-diabetes-mellitus-a-meta-analysis
#8
Junping Wei, Huijuan Zheng, Liansheng Wang, Qiuhong Wang, Fan Wei, Litao Bai
Background Mobile health interventions utilising telephone calls are promising tools for diabetes management. However, there is still a lack of convincing evidence demonstrating their beneficial effects on cardiovascular risk factors. The aim of this meta-analysis of randomised controlled trials was to assess the effect of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients. Methods Two independent reviewers searched three online databases (PubMed, the Cochrane Library and EMBASE) to identify relevant English-language randomised controlled trials up to September 2017...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29228048/trends-in-the-management-levels-of-metabolic-risk-factors-in-middle-aged-and-elderly-patients-with-type-2-diabetes-mellitus-the-korean-national-health-and-nutrition-examination-survey-1998-2014
#9
Sukyung Cho, Haeun Jang, Kyong Park
The present study examined the temporal trends in the management of blood pressure, glucose, and lipid levels among middle-aged and elderly patients with type 2 diabetes using data from the Korean National Health and Nutrition Examination Survey (1998-2014). A total of 3,689 patients with diabetes were included and divided into middle-aged (30-64 years old) and elderly (≥65 years old) groups. Demographic and lifestyle data were obtained using a self-reported questionnaire, and trained medical staff obtained fasting blood samples and blood pressure data...
2017: PloS One
https://www.readbyqxmd.com/read/29226694/effectiveness-of-motivational-interviewing-for-improving-physical-activity-self-management-for-adults-with-type-2-diabetes-a-review
#10
Patricia Davern Soderlund
Objectives This review examines the effectiveness of motivational interviewing for physical activity self-management for adults diagnosed with diabetes mellitus type 2. Motivational interviewing is a patient centered individually tailored counseling intervention that aims to elicit a patient's own motivation for health behavior change. Review questions include (a) How have motivational interviewing methods been applied to physical activity interventions for adults with diabetes mellitus type 2? (b) What motivational interviewing approaches are associated with successful physical activity outcomes with diabetes mellitus 2? Methods Database searches used PubMed, CINAHL, and PsycINFO for the years 2000 to 2016...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/29225801/histologic-regression-of-fibrillary-glomerulonephritis-the-first-report-of-biopsy-proven-spontaneous-resolution-of-disease
#11
Miroslav Sekulic, Samih H Nasr, Joseph P Grande, Lynn D Cornell
Fibrillary glomerulonephritis (FGN) is a rare immune complex type glomerulonephritis characterized by glomerular deposition of randomly oriented fibrils measuring 10-30 nm in thickness, and typically presents with proteinuria with or without renal insufficiency and hematuria. We present a case in which a patient initially presented at age 41 years with nephrotic-range proteinuria and hypertension; a kidney biopsy showed FGN. The patient was treated with angiotensin receptor blockage only, without immunosuppression as per patient preference, and the level of protein in the urine improved...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29221543/community-health-workers-in-diabetes-prevention-and-management-in-developing-countries
#12
REVIEW
Halimatou Alaofè, Ibitola Asaolu, Jennifer Ehiri, Hayley Moretz, Chisom Asuzu, Mobolanle Balogun, Olayinka Abosede, John Ehiri
BACKGROUND: There is limited evidence regarding the effect of community health worker (CHW) interventions for prevention and management of the burgeoning epidemic of noncommunicable diseases (NCDs) in low- and middle-income countries (LMICs). The objective of this review was to critically appraise evidence regarding the effectiveness of CHW interventions for prevention and management of type 2 diabetes mellitus (T2DM) in LMICs. METHODS: To identify studies that reported the effect of CHW interventions for prevention and management of T2DM in LMICs, Medline/PubMed, EMBASE, Web of Science (Science and Social Science Citation Indices), EBSCO (PsycINFO and CINAHL), POPLINE, the Cochrane Metabolic and Endocrine Disorders Group's Specialized Register, the Cochrane Central Register of Controlled Trials, the Grey literature (Google, Google Scholar), and reference lists of identified articles were searched from inception to May 31, 2017...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29219128/economic-burden-of-managing-type-2-diabetes-mellitus-analysis-from-a-teaching-hospital-in-malaysia
#13
Aniza Ismail, Leny Suzana Suddin, Saperi Sulong, Zafar Ahmed, Nor Azmi Kamaruddin, Norlela Sukor
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disease that consumes a large amount of health-care resources. It is essential to estimate the cost of managing T2DM to the society, especially in developing countries. Economic studies of T2DM as a primary diagnosis would assist efficient health-care resource allocation for disease management. OBJECTIVE: This study aims to measure the economic burden of T2DM as the primary diagnosis for hospitalization from provider's perspective...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29218127/the-effect-of-group-discussion-based-education-on-self-management-of-adults-with-type-2-diabetes-mellitus-compared-with-usual-care-a-randomized-control-trial
#14
Hosein Habibzadeh, Akbar Sofiani, Leyla Alilu, Mark Gillespie
Objectives: We sought to determine the effect of group discussion-based education on the self-management capability of patients with type 2 diabetes in Iran. Methods: This randomized control trial was conducted on 90 patients with type 2 diabetes. Participants were allocated randomly into one of two groups; intervention and control. The intervention group received the group discussion-based education while the control group received routine care only. The Lin's self-management questionnaire was completed at baseline and three months post-intervention...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29217884/how-harmful-can-herbal-remedies-be-a-case-of-severe-acute-tubulointerstitial-nephritis
#15
P Beniwal, N Gaur, S K Singh, N Raveendran, V Malhotra
Acute interstitial nephritis (AIN) is a condition in which acute kidney injury (AKI) is characterized by the histological finding of interstitial inflammation. Hyponidd is an ayurvedic drug containing Momordica charantia, Gymnema sylvestre, Swertia chirata, etc., used for the treatment of Type 2 diabetes mellitus (DM) and polycystic ovarian disease as an insulin sensitizer. There are no case reports of AIN caused by this drug yet. We report a biopsy-proven case of AKI due to severe AIN associated with the use of hyponidd tablet in a 60-year-old male with DM and hypertension...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29215196/comparison-between-sglt2-inhibitors-and-pioglitazone-as-additions-to-insulin-therapy-in-type-2-diabetes-a-systematic-review-with-an-indirect-comparison-meta-analysis
#16
Yun Kyung Cho, Ye-Jee Kim, Yu Mi Kang, Seung Eun Lee, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung
AIMS/INTRODUCTION: We aimed to evaluate the efficacy and safety of pioglitazone (PIO) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) as additions to insulin therapy for the management of type 2 diabetes mellitus (T2D). MATERIALS AND METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and ClinicalTrials. gov through December 2016. Randomized controlled trials (RCTs) published in English that compared SGLT2i plus insulin (SGLT2i/INS) or PIO plus insulin (PIO/INS) with placebo plus insulin (PCB/INS) in T2D patients were included...
December 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29214049/latent-autoimmune-diabetes-of-adulthood-case-report
#17
Cristen P Page, Brian Fitzgerald, Emily M Hawes
Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Case presentation: A 49-year-old Caucasian female with history of pituitary adenoma and Graves' disease with history of thyroid ablation presented in the outpatient setting due to hand tingling of her right middle finger that was worse in the mornings and improved throughout the day...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29211039/association-of-social-support-and-medication-adherence-in-chinese-patients-with-type-2-diabetes-mellitus
#18
Linni Gu, Shaomin Wu, Shuliang Zhao, Huixuan Zhou, Shengfa Zhang, Min Gao, Zhiyong Qu, Weijun Zhang, Donghua Tian
The prevalence of diabetes is steadily increasing in China. When diabetes is uncontrolled, it generates dire consequences for health and well-being. Numerous studies have shown that health outcomes were associated with social support and medication adherence. Previous study confirmed that social support was associated with medication adherence in patients with heart failure, HIV diseases, and first-episode psychosis. However, the relationship between social support and medication adherence in patients with type 2 diabetes mellitus (T2DM) is remains unclear...
December 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29209438/incorporation-of-suboptimal-health-status-as-a-potential-risk-assessment-for-type-ii-diabetes-mellitus-a-case-control-study-in-a-ghanaian-population
#19
Eric Adua, Peter Roberts, Wei Wang
Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29208621/retrospective-multicohort-analysis-of-the-clinical-practice-research-datalink-cprd-to-determine-differences-in-the-cost-of-medication-wastage-dispensing-fees-and-prescriber-time-of-issuing-either-short-60-days-or-long-%C3%A2-60-days-prescription-lengths-in-primary
#20
Brett Doble, Rupert Payne, Amelia Harshfield, Edward C F Wilson
OBJECTIVES: To investigate patterns of early repeat prescriptions and treatment switching over an 11-year period to estimate differences in the cost of medication wastage, dispensing fees and prescriber time for short (<60 days) and long (≥60 days) prescription lengths from the perspective of the National Health Service in the UK. SETTING: Retrospective, multiple cohort study of primary care prescriptions from the Clinical Practice Research Datalink. PARTICIPANTS: Five random samples of 50 000 patients each prescribed oral drugs for (1) glucose control in type 2 diabetes mellitus (T2DM); (2) hypertension in T2DM; (3) statins (lipid management) in T2DM; (4) secondary prevention of myocardial infarction; and (5) depression...
December 4, 2017: BMJ Open
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