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Ikuko Kashino, Shamima Akter, Tetsuya Mizoue, Norie Sawada, Ayaka Kotemori, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Tomio Nakayama, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Manami Inoue, Chisato Nagata, Atsuko Sadakane, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
Coffee is a rich source of bioactive compounds that have potential anti-carcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,276 person-years, 6,711 incident colorectal cancer cases were identified...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama, Ken Ninomiya, Junichi Yamane, Kazuya Kitamura, Seiji Ueda
Postoperative posterior spinal cord shift (PSS) has been considered a required radiographic endpoint of posterior decompression procedures. To achieve PSS, laminoplasty for cervical compressive myelopathy (CCM) has been consecutively performed on four or more laminae (C2-C7, C3-C7, or C3-C6). However, the clinical significance of PSS remains controversial. By selecting the surgically treated laminae, selective laminectomy (SL) can achieve adequate decompression without disturbing the extensor musculature and facet joints...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Masayuki Ueno, Taichi Shimazu, Norie Sawada, Shoichiro Tsugane, Yoko Kawaguchi
Self-reported measures of oral health are often used to assess oral health in populations or groups, but their validity or reliability needs repeated confirmation. The objective of this cross-sectional study was to evaluate the validity of self-reported tooth counts and masticatory status, using data obtained from a sample of Japanese adults. A total of 2,356 adults aged 40 to 75 years participated in a questionnaire survey and a clinical oral examination from 2013 through 2016. Self-reported measures were compared with clinically measured values...
February 8, 2018: Journal of Oral Rehabilitation
Lisa DeTora, Cate Foster, Mukund Nori, Donna Simcoe, Catherine Skobe, Dikran Toroser
It is relatively easy to begin policy documents with a general assertion that ethics will be followed. Less obvious is how to ensure that day-to-day activities are consonant with ethical standards. We suggest that using day-to-day publication activities as the driver for building policies and procedures can promote ethical practices from the ground up. Although basic principles of ethical publication practice may seem straightforward to some, for others this information may require explanation, interpretation and context...
February 8, 2018: International Journal of Clinical Practice
Norie Yamada, Ryuichi Sugiyama, Sayuri Nitta, Asako Murayama, Minoru Kobayashi, Chiaki Okuse, Michihiro Suzuki, Kiyomi Yasuda, Hiroshi Yotsuyanagi, Kyoji Moriya, Kazuhiko Koike, Takaji Wakita, Takanobu Kato
The emergence of resistance mutations in the reverse transcriptase gene of hepatitis B virus (HBV) is associated with treatment failure. Entecavir (ETV) is one of the most potent anti-HBV reagents; it has a very low resistance rate and is used as the first-line treatment for chronic hepatitis B. In this study, we isolated HBVs in 4 ETV-refractory patients (2 with viral breakthrough, 1 with partial virological response, and 1 with flare-up) and assessed ETV resistance using replication-competent 1.38-fold HBV genome-length molecular clones...
April 2017: Hepatology Communications
Hong-Bin Chen, Clemens Gneiting, Ping-Yuan Lo, Yueh-Nan Chen, Franco Nori
The incoherent dynamical properties of open quantum systems are generically attributed to an ongoing correlation between the system and its environment. Here, we propose a novel way to assess the nature of these system-environment correlations by examining the system dynamics alone. Our approach is based on the possibility or impossibility to simulate open-system dynamics with Hamiltonian ensembles. As we show, such (im)possibility to simulate is closely linked to the system-environment correlations. We thus define the nonclassicality of open-system dynamics in terms of the nonexistence of a Hamiltonian-ensemble simulation...
January 19, 2018: Physical Review Letters
E M Harding-Esch, E C Cousins, S-L C Chow, L T Phillips, C L Hall, N Cooper, S S Fuller, A V Nori, R Patel, S Thomas-William, G Whitlock, S J E Edwards, M Green, J Clarkson, B Arlett, J K Dunbar, C M Lowndes, S T Sadiq
BACKGROUND: Rapid Point-Of-Care Tests for Chlamydia trachomatis (CT) may reduce onward transmission and reproductive sexual health (RSH) sequelae by reducing turnaround times between diagnosis and treatment. The io® single module system (Atlas Genetics Ltd.) runs clinical samples through a nucleic acid amplification test (NAAT)-based CT cartridge, delivering results in 30min. METHODS: Prospective diagnostic accuracy study of the io® CT-assay in four UK Genito-Urinary Medicine (GUM)/RSH clinics on additional-to-routine self-collected vulvovaginal swabs...
January 10, 2018: EBioMedicine
Antonietta Santoro, Chiara Carmela Spinelli, Stefania Martucciello, Stefania Lucia Nori, Mario Capunzo, Annibale Alessandro Puca, Elena Ciaglia
Ongoing studies evidence cellular senescence in undifferentiated and specialized cells from tissues of all ages. Although it is believed that senescence plays a wider role in several stress responses in the mature age, its participation in certain physiological and pathological processes throughout life is coming to light. The "senescence machinery" has been observed in all brain cell populations, including components of innate immunity (e.g., microglia and astrocytes). As the beneficial versus detrimental implications of senescence is an open question, we aimed to analyze the contribution of immune responses in regulatory mechanisms governing its distinct functions in healthy (development, organogenesis, danger patrolling events) and diseased brain (glioma, neuroinflammation, neurodeneration), and the putative connection between cellular and molecular events governing the 2 states...
February 1, 2018: Journal of Leukocyte Biology
Chie Taguchi, Yoshimi Kishimoto, Norie Suzuki-Sugihara, Emi Saita, Mika Usuda, Wei Wang, Yasunobu Masuda, Kazuo Kondo
BACKGROUND AND OBJECTIVES: Eggs, an important source of high-quality protein, contain a variety of key nutrients and antioxidants. Here we conducted an intervention study to evaluate whether the additional consumption of one egg per day would affect the daily nutritional intakes and blood antioxidant status in Japanese woman university students. METHODS AND STUDY DESIGN: For 4 weeks, the 14 subjects were provided a nutritious breakfast including one boiled egg, and they were asked to keep a daily dietary record...
2018: Asia Pacific Journal of Clinical Nutrition
Yukiko Cho, Takashi Ideue, Megumi Nagayama, Norie Araki, Tokio Tani
Satellite I RNA, a noncoding (nc)RNA transcribed from repetitive regions in human centromeres, binds to Aurora kinase B and forms a ncRNP complex required for chromosome segregation. To examine its function in this process, we purified satellite I ncRNP complex from nuclear extracts prepared from asynchronized or mitotic (M) phase-arrested HeLa cells and then carried out LC/MS to identify proteins bound to satellite I RNA. RBMX (RNA-binding motif protein, X-linked), which was isolated from M phase-arrested cells, was selected for further characterization...
January 31, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Junna Horio, Hiroki Kaneko, Kei Takayama, Kinichi Tuzuki, Hiroko Kakihara, Miou Iwami, Yoshikatsu Kawase, Taichi Tsunekawa, Naoko Yamaguchi, Norie Nonobe, Hiroko Terasaki
PURPOSE: To investigate the refractive characteristics of Japanese children with Down syndrome. STUDY DESIGN: Retrospective study. METHODS: The clinical records of refractive errors and ocular manifestations in children with Down syndrome who visited the Aichi Children's Health and Medical Center between November 2001 and January 2016 were retrospectively reviewed. The children were divided into the 3 following groups depending on their age: group 1 (≤ 6 years), group 2 (7-12 years), and group 3 (13-19 years)...
January 30, 2018: Japanese Journal of Ophthalmology
Aida Ravarian, Roshanak Vameghi, Mohammad Heidarzadeh, Shahin Nariman, Setareh Sagheb, Fariba Nori, Farhoud Saeedershadi, Mehdi Norozi
Objective: The aim of this study was to determine factors influencing the number of times neonatal intensive care unit admitted preterm infants attend Neonatal Follow up and Early Intervention services (NFEI) during first year of life. Materials &Methods: A parent-report questionnaire was administered via phone after the first birthday of preterm infants admitted to the NICU at Arash Hospital, Tehran, for at least 24 h, and who received standard NICU-based therapeutic services, from Apr 2014 to Feb 2015...
2018: Iranian Journal of Child Neurology
Shoko Yoshida, Tsuyoshi Shimo, Yurika Murase, Kiyofumi Takabatake, Koji Kishimoto, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Hitoshi Nagatsuka, Akira Sasaki
BACKGROUND/AIM: This study evaluated the associations between bone invasion of gingival squamous cell carcinoma (SCC) and clinicopathological manifestations, and aimed to determine whether bone invasion is an independent prognostic factor in gingival SCC. PATIENTS AND METHODS: The study was a retrospective review of 78 patients with gingival SCC who underwent surgery with curative intent. The level of bone invasion was pathologically categorized as medullary, cortical or no bone invasion...
February 2018: Anticancer Research
Naofumi Ito, Kaoru Katoh, Hiroko Kushige, Yutaka Saito, Terumasa Umemoto, Yu Matsuzaki, Hiroshi Kiyonari, Daiki Kobayashi, Minami Soga, Takumi Era, Norie Araki, Yasuhide Furuta, Toshio Suda, Yasuyuki Kida, Kunimasa Ohta
Recently, we reported that bacterial incorporation induces cellular transdifferentiation of human fibroblasts. However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. Here, we found that cellular transdifferentiation is caused by ribosomes. Ribosomes, isolated from both prokaryotic and eukaryotic cells, induce the formation of embryoid body-like cell clusters. Numerous ribosomes are incorporated into both the cytoplasm and nucleus through trypsin-activated endocytosis, which leads to cell-cluster formation...
January 26, 2018: Scientific Reports
Yoshichika Miyazaki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Toshiki Seki, Kotaro Miura, Norie Suzuki-Sugihara, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
AIM: Fibroblast growth factor-21 (FGF-21) is a metabolic regulator with beneficial effects on glucolipid metabolism. Since FGF-21 has lipid-lowering, anti-inflammatory and anti-oxidant properties, it may play a protective role against atherosclerosis. However, blood FGF-21 levels in coronary artery disease (CAD) or peripheral artery disease (PAD) have not been elucidated. METHODS: We measured plasma FGF-21 levels in 417 patients undergoing coronary angiography, who also had ankle-brachial index test for PAD screening...
January 24, 2018: Journal of Atherosclerosis and Thrombosis
Yoshimi Kishimoto, Emi Saita, Kotaro Miura, Toshiki Seki, Yoshichika Miyazaki, Norie Suzuki-Sugihara, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Yoshichika Miyazaki, Emi Saita, Kotaro Miura, Toshiki Seki, Norie Suzuki-Sugihara, Yukinori Ikegami, Reiko Ohmori, Yoshimi Kishimoto, Kazuo Kondo, Yukihiko Momiyama
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Joshua C Stein, Yeisoo Yu, Dario Copetti, Derrick J Zwickl, Li Zhang, Chengjun Zhang, Kapeel Chougule, Dongying Gao, Aiko Iwata, Jose Luis Goicoechea, Sharon Wei, Jun Wang, Yi Liao, Muhua Wang, Julie Jacquemin, Claude Becker, Dave Kudrna, Jianwei Zhang, Carlos E M Londono, Xiang Song, Seunghee Lee, Paul Sanchez, Andrea Zuccolo, Jetty S S Ammiraju, Jayson Talag, Ann Danowitz, Luis F Rivera, Andrea R Gschwend, Christos Noutsos, Cheng-Chieh Wu, Shu-Min Kao, Jhih-Wun Zeng, Fu-Jin Wei, Qiang Zhao, Qi Feng, Moaine El Baidouri, Marie-Christine Carpentier, Eric Lasserre, Richard Cooke, Daniel da Rosa Farias, Luciano Carlos da Maia, Railson S Dos Santos, Kevin G Nyberg, Kenneth L McNally, Ramil Mauleon, Nickolai Alexandrov, Jeremy Schmutz, Dave Flowers, Chuanzhu Fan, Detlef Weigel, Kshirod K Jena, Thomas Wicker, Mingsheng Chen, Bin Han, Robert Henry, Yue-Ie C Hsing, Nori Kurata, Antonio Costa de Oliveira, Olivier Panaud, Scott A Jackson, Carlos A Machado, Michael J Sanderson, Manyuan Long, Doreen Ware, Rod A Wing
The genus Oryza is a model system for the study of molecular evolution over time scales ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the Oryza species tree, we show that despite few large-scale chromosomal rearrangements rapid species diversification is mirrored by lineage-specific emergence and turnover of many novel elements, including transposons, and potential new coding and noncoding genes. Our study resolves controversial areas of the Oryza phylogeny, showing a complex history of introgression among different chromosomes in the young 'AA' subclade containing the two domesticated species...
January 22, 2018: Nature Genetics
Saki Narita, Eiko Saito, Norie Sawada, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Junko Ishihara, Ribeka Takachi, Kenji Shibuya, Manami Inoue, Shoichiro Tsugane
While many epidemiological studies have studied the association between lung cancer risk and fruits and vegetable consumption, the major sources of antioxidant vitamins, only a few have investigated the direct association with antioxidants in consideration of cancer subtypes and smoking status. Here, we examined the association between consumption of antioxidant vitamins and lung cancer risk in one of the largest prospective cohort studies in Japan. We investigated the association of dietary antioxidant vitamins intake, namely retinol, vitamin C, vitamin E, α-carotene, and β-carotene, and subsequent incidence of lung cancer among 38,207 men and 41,498 women in the Japan Public Health Center-based Prospective Study...
January 22, 2018: International Journal of Cancer. Journal International du Cancer
Hadrien Charvat, Shizuka Sasazuki, Taichi Shimazu, Sanjeev Budhathoki, Manami Inoue, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, Shoichiro Tsugane
While the impact of tobacco consumption on the occurrence of lung cancer is well-established, risk estimation could be improved by risk prediction models that consider various smoking habits, such as quantity, duration, and time since quitting. We constructed a risk prediction model using a population of 59,161 individuals from JPHC Study Cohort II. A parametric survival model was used to assess the impact of age, gender and smoking-related factors (cumulative smoking intensity measured in pack-years, age at initiation, and time since cessation)...
January 18, 2018: Cancer Science
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