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https://www.readbyqxmd.com/read/28345093/diffusion-of-active-dimers-in-a-couette-flow
#1
Tanwi Debnath, Pulak K Ghosh, Franco Nori, Yunyun Li, Fabio Marchesoni, Baowen Li
We study the 3D dynamics of an elastic dimer consisting of an active swimmer bound to a passive cargo, both suspended in a Couette flow. Using numerical simulations, we determine the diffusivity of such an active dimer in the presence of long-range hydrodynamic interactions for different values of its self-propulsion speed and the Couette flow. We observe that the effect of hydrodynamic interactions is greatly enhanced under the condition that self-propulsion is strong enough to contrast the shear flow. The magnitude of the effect grows with the size of the dimer's constituents relative to their distance, which makes it appreciable under experimental conditions...
March 27, 2017: Soft Matter
https://www.readbyqxmd.com/read/28337559/dietary-fiber-intake-and-risk-of-breast-cancer-defined-by-estrogen-and-progesterone-receptor-status-the-japan-public-health-center-based-prospective-study
#2
Saki Narita, Manami Inoue, Eiko Saito, Sarah K Abe, Norie Sawada, Junko Ishihara, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Kenji Shibuya, Shoichiro Tsugane
PURPOSE: Epidemiological studies have suggested a protective effect of dietary fiber intake on breast cancer risk while the results have been inconsistent. Our study aimed to investigate the association between dietary fiber intake and breast cancer risk and to explore whether this association is modified by reproductive factors and hormone receptor status of the tumor. METHODS: A total of 44,444 women aged 45 to 74 years from the Japan Public Health Center-based Prospective Study were included in analyses...
March 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#3
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28324761/chocolate-consumption-and-risk-of-stroke-among-men-and-women-a-large-population-based-prospective-cohort-study
#4
Jia-Yi Dong, Hiroyasu Iso, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane
BACKGROUND AND AIMS: Chocolate consumption may have a beneficial effect on cardiovascular health, but evidence from prospective cohort studies is still limited. We aimed to examine the prospective associations between chocolate consumption and risk of stroke among men and women in a large population-based cohort. METHODS: A total of 38,182 men and 46,415 women aged 44-76 years, and free of cardiovascular disease, diabetes, and cancer at baseline in 1995 and 1998, were followed up until the end of 2009 and 2010, respectively...
March 4, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28318975/a-large-and-consistent-phylogenomic-dataset-supports-sponges-as-the-sister-group-to-all-other-animals
#5
Paul Simion, Hervé Philippe, Denis Baurain, Muriel Jager, Daniel J Richter, Arnaud Di Franco, Béatrice Roure, Nori Satoh, Éric Quéinnec, Alexander Ereskovsky, Pascal Lapébie, Erwan Corre, Frédéric Delsuc, Nicole King, Gert Wörheide, Michaël Manuel
Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera) are the sister group to all other animals ("Porifera-sister" hypothesis), consistent with a single origin of the gut, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnidarians). In contrast, several other studies have recovered an alternative topology in which ctenophores are the sister group to all other animals (including sponges)...
March 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28318299/lithocholic-acid-a-new-emergent-protector-of-intestinal-calcium-absorption-under-oxidant-conditions
#6
Ana M Marchionatti, Adriana Pérez, María A Rivoira, Valeria A Rodríguez, Nori G Tolosa de Talamoni
LCA and 1,25(OH)2D3 are vitamin D receptor ligands with different binding affinity. The secosteroid stimulates intestinal Ca(2+) absorption. Whether LCA alters this process remains unknown. The aim of our work was to determine the effect of LCA on intestinal Ca(2+) absorption in the absence or presence of NaDOC, bile acid that inhibits the cation transport. The data show that LCA by itself did not alter intestinal Ca(2+) absorption, but prevented the inhibitory effect of NaDOC. The concomitant administration of LCA avoided the reduction of intestinal alkaline phosphatase activity caused by NaDOC...
March 20, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28314465/data-capture-and-communication-during-transfers-to-definitive-care-in-an-inclusive-trauma-system
#7
Nori L Bradley, Naisan Garraway, Nathaniel Bell, Nasira Lakha, S Morad Hameed
INTRODUCTION: Background trauma survivors in rural areas transferred to urban centers have higher mortality than trauma patients admitted directly to urban centers. Transfer data in trauma registries is important for injury control. Prehospital and early physiologic data may reflect processes of pre-hospital care. British Columbia currently has no standardized process for trauma patient data transfer. PATIENTS AND METHODS: We performed a retrospective data analysis for major trauma patients (ISS>15) transferred to a Level I trauma center over a 1year period (n=243)...
November 5, 2016: Injury
https://www.readbyqxmd.com/read/28302344/comparison-of-weighed-food-record-procedures-for-the-reference-methods-in-two-validation-studies-of-food-frequency-questionnaires
#8
Yuri Ishii, Junko Ishihara, Ribeka Takachi, Yurie Shinozawa, Nahomi Imaeda, Chiho Goto, Kenji Wakai, Toshiaki Takahashi, Hiroyasu Iso, Kazutoshi Nakamura, Junta Tanaka, Taichi Shimazu, Taiki Yamaji, Shizuka Sasazuki, Norie Sawada, Motoki Iwasaki, Haruo Mikami, Kiyonori Kuriki, Mariko Naito, Naoko Okamoto, Fumi Kondo, Satoyo Hosono, Naoko Miyagawa, Etsuko Ozaki, Sakurako Katsuura-Kamano, Keizo Ohnaka, Hinako Nanri, Noriko Tsunematsu-Nakahata, Takamasa Kayama, Ayako Kurihara, Shiomi Kojima, Hideo Tanaka, Shoichiro Tsugane
BACKGROUND: Although open-ended dietary assessment methods, such as weighed food records (WFRs), are generally considered to be comparable, differences between procedures may influence outcome when WFRs are conducted independently. In this paper, we assess the procedures of WFRs in two studies to describe their dietary assessment procedures and compare the subsequent outcomes. METHODS: WFRs of 12 days (3 days for four seasons) were conducted as reference methods for intake data, in accordance with the study protocol, among a subsample of participants of two large cohort studies...
March 13, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28283695/restructuring-the-navigational-field-individual-predisposition-towards-field-independence-predicts-preferred-navigational-strategy
#9
Maddalena Boccia, Laura Piccardi, Adele D'Alessandro, Raffaella Nori, Cecilia Guariglia
To successfully navigate within an environment, individuals have to organize the spatial information in terms of salient landmarks, paths and general layout of the navigational environment. They may differ in the strategy they adopt to orientate themselves, with some individuals preferring to use salient landmarks (landmark spatial style, L-SS), others preferring to plan routes or paths through an egocentric strategy in which landmarks are connected with each other (route spatial style, R-SS) and others still create a global map-like configuration of the environment regardless of their own position in the environment (survey spatial style, S-SS)...
March 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28276660/complement-alternative-pathway-deficiency-in-recipients-protects-kidney-allograft-from-ischemia-reperfusion-injury-and-alloreactive-t-cell-response
#10
Federica Casiraghi, Nadia Azzollini, Marta Todeschini, Sonia Fiori, Regiane Aparecida Cavinato, Paola Cassis, Samantha Solini, Francesca Pezzuto, Marilena Mister, Joshua M Thurman, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
Despite the introduction of novel and more targeted immunosuppressive drugs, the long-term survival of kidney transplants has not improved satisfactorily. Early antigen-independent intra-graft inflammation plays a critical role in the initiation of the alloimmune response and impacts long-term graft function. Complement activation is a key player both in ischemia/reperfusion injury (IRI) as well as in adaptive anti-graft immune response after kidney transplantation. Since the alternative pathway (AP) amplifies complement activation regardless of the initiation pathways and renal IR injured cells undergo uncontrolled complement activation, we wondered whether selective blockade of AP could be a strategy for prolonging kidney graft survival...
March 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28265721/association-between-type-2-diabetes-and-risk-of-cancer-mortality-a-pooled-analysis-of-over-771-000-individuals-in-the-asia-cohort-consortium
#11
Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N Luu, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Yong-Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You-Lin Qiao, San-Lin You, Renwei Wang, Myung-Hee Shin, Wen-Harn Pan, Mangesh S Pednekar, Shoichiro Tsugane, Hui Cai, Jian-Min Yuan, Yu-Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D Potter
AIMS/HYPOTHESIS: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. METHODS: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia...
March 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28264875/prediagnostic-calcium-intake-and-lung-cancer-survival-a-pooled-analysis-of-12-cohort-studies
#12
Danxia Yu, Yumie Takata, Stephanie A Smith-Warner, William Blot, Norie Sawada, Emily White, Neal Freedman, Kim Robien, Edward L Giovannucci, Xuehong Zhang, Yikyung Park, Yu-Tang Gao, Rowan T Chlebowski, Arnulf Langhammer, Gong Yang, Gianluca Severi, Jonas Manjer, Kay-Tee Khaw, Elisabete Weiderpass, Linda M Liao, Neil E Caporaso, Steinar Krokstad, Kristian Hveem, Rashmi Sinha, Regina G Ziegler, Shoichiro Tsugsane, Yong-Bing Xiang, Mattias Johannson, Wei Zheng, Xiao-Ou Shu
BACKGROUND: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. METHODS: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calcium intake was assessed using food-frequency questionnaires at baseline in each cohort and standardized to caloric intake of 2000 kcal/d for women and 2500 kcal/d for men...
March 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28262584/accelerated-partial-breast-irradiation-using-intensity-modulated-radiotherapy-versus-whole-breast-irradiation-health-related-quality-of-life-final-analysis-from-the-florence-phase-3-trial
#13
Icro Meattini, Calogero Saieva, Guido Miccinesi, Isacco Desideri, Giulio Francolini, Vieri Scotti, Livia Marrazzo, Stefania Pallotta, Fiammetta Meacci, Cristina Muntoni, Benedetta Bendinelli, Luis Jose Sanchez, Marco Bernini, Lorenzo Orzalesi, Jacopo Nori, Simonetta Bianchi, Lorenzo Livi
BACKGROUND: Accelerated partial breast irradiation (APBI) represents a valid option for selected early breast cancer (BC). We recently published the 5-year results of the APBI-IMRT-Florence phase 3 randomised trial (NCT02104895), showing a very low rate of disease failure, with acute and early-late toxicity in favour of APBI. We present the early and 2-year follow-up health-related quality of life (HRQoL) results. METHODS: Eligible patients were women aged more than 40 years with early BC suitable for breast-conserving surgery...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28261609/correlation-between-mir-148-expression-in-vitreous-and-severity-of-rhegmatogenous-retinal-detachment
#14
Taichi Tsunekawa, Hiroki Kaneko, Kei Takayama, Shiang-Jyi Hwang, Akio Oishi, Yosuke Nagasaka, Fuxiang Ye, Takeshi Iwase, Norie Nonobe, Shinji Ueno, Yasuki Ito, Shunsuke Yasuda, Toshiyuki Matsuura, Hideyuki Shimizu, Ayana Suzumura, Keiko Kataoka, Hiroko Terasaki
Purpose. We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD. Methods. The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28257491/the-association-between-adult-attained-height-and-sitting-height-with-mortality-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#15
Norie Sawada, Petra A Wark, Melissa A Merritt, Shoichiro Tsugane, Heather A Ward, Sabina Rinaldi, Elisabete Weiderpass, Laureen Dartois, Mathilde His, Marie-Christine Boutron-Ruault, Renée Turzanski-Fortner, Rudolf Kaaks, Kim Overvad, María-Luisa Redondo, Noemie Travier, Elena Molina-Portillo, Miren Dorronsoro, Lluis Cirera, Eva Ardanaz, Aurora Perez-Cornago, Antonia Trichopoulou, Pagona Lagiou, Elissavet Valanou, Giovanna Masala, Valeria Pala, Petra Hm Peeters, Yvonne T van der Schouw, Olle Melander, Jonas Manjer, Marisa da Silva, Guri Skeie, Anne Tjønneland, Anja Olsen, Marc J Gunter, Elio Riboli, Amanda J Cross
Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28256931/barriers-to-discharge-from-inpatient-rehabilitation-a-teamwork-approach
#16
Lisanne Catherine Cruz, Jeffrey S Fine, Subhadra Nori
Purpose In order to prevent adverse events during the discharge process, coordinating appropriate community resources, medication reconciliation, and patient education needs to be implemented before the patient leaves the hospital. This coordination requires communication and effective teamwork amongst staff members. In order to address these concerns, the purpose of this paper is to incorporate the TeamSTEPPS principles to develop a discharge plan that would best meet the needs of the patients as they return to the community...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28250457/genome-wide-analyses-identify-common-variants-associated-with-macular-telangiectasia-type-2
#17
Thomas S Scerri, Anna Quaglieri, Carolyn Cai, Jana Zernant, Nori Matsunami, Lisa Baird, Lea Scheppke, Roberto Bonelli, Lawrence A Yannuzzi, Martin Friedlander, Catherine A Egan, Marcus Fruttiger, Mark Leppert, Rando Allikmets, Melanie Bahlo
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS) with 476 cases and 1,733 controls of European ancestry. Genome-wide significant associations (P < 5 × 10(-8)) were identified at three independent loci (rs73171800 at 5q14.3, P = 7.74 × 10(-17); rs715 at 2q34, P = 9.97 × 10(-14); rs477992 at 1p12, P = 2.60 × 10(-12)) and then replicated (P < 0...
February 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28230907/estrogenic-suppression-of-binge-like-eating-elicited-by-cyclic-food-restriction-and-frustrative-nonreward-stress-in-female-rats
#18
Maria Vittoria Micioni Di Bonaventura, Thomas A Lutz, Adele Romano, Mariangela Pucci, Nori Geary, Lori Asarian, Carlo Cifani
Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge-like eating in female rats and their control by estrogens. Binge-like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward-stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Intact rats showed binge-like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (periovulatory) phase...
February 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28228614/current-solutions-for-long-segment-tracheal-reconstruction
#19
Ahmed A Abouarab, Hany H Elsayed, Hussein Elkhayat, Ahmed Mostafa, David C Cleveland, Ahmed El Nori
This article is a continuation of previous reviews about the appropriate method for long-segment tracheal reconstruction. We attempted to cover the most recent, successful and promising results of the different solutions for reconstruction that are rather innovative and suitable for imminent clinical application. Latest efforts to minimize the limitations associated with each method have been covered as well. In summary, autologous and allogenic tissue reconstruction of the trachea have been successful methods for reconstruction experimentally and clinically...
February 23, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28216143/enhanced-functional-recovery-from-spinal-cord-injury-in-aged-mice-after-stem-cell-transplantation-through-hgf-induction
#20
Morito Takano, Soya Kawabata, Shinsuke Shibata, Akimasa Yasuda, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Akio Iwanami, Hayao Ebise, Keisuke Horiuchi, Hideyuki Okano, Masaya Nakamura
The number of elderly patients with spinal cord injury (SCI) is increasing worldwide, representing a serious burden for both the affected patients and the community. Previous studies have demonstrated that neural stem cell (NSC) transplantation is an effective treatment for SCI in young animals. Here we show that NSC transplantation is as effective in aged mice as it is in young mice, even though aged mice exhibit more severe neurological deficits after SCI. NSCs grafted into aged mice exhibited better survival than those grafted into young mice...
March 14, 2017: Stem Cell Reports
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