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Sergio Alberto Ramírez-García, Diana García-Cruz, Iván Cervantes-Aragón, Wadih Emilio Bitar-Alatorre, Ingrid Patricia Dávalos-Rodríguez, Nory Omayra Dávalos-Rodríguez, Jorge Román Corona-Rivera, José Sánchez-Corona
Background: Achondrogenesis is a skeletal dysplasia characterized primarily by short stature, severe micromelia, short and narrow chest, prematurity, polyhydramnios, fetal hydrops, and in utero or neonatal death. Based on the radiological and histopathological findings, there are three types of achondrogenesis: type 1A (Houston-Harris), type 1B (Fraccaro) and type 2 (Langer-Saldino). Clinical case: A premature female product was studied whose clinical, radiological and histopathological characteristics were compatible with achondrogenesis Type 1A...
2018: Cirugia y Cirujanos
Asuka Kawachi, Taichi Shimazu, Sanjeev Budhathoki, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Evidence on the association between BMI, height, and endometrial cancer risk, including by subtypes, among Asian populations remains limited. We evaluated the impact of BMI and height on the risk of endometrial cancer, overall and by histological subtype. We prospectively investigated 53 651 Japanese women aged 40-69 years. With an average follow-up duration of 18.6 years, 180 newly diagnosed endometrial cancers were reported, including 119 type 1 and 21 type 2. The association between BMI, height, and endometrial cancer risk was assessed using a Cox proportional hazards regression model with adjustment for potential confounders...
April 18, 2018: European Journal of Cancer Prevention
Frank Weinhold, Davood Nori-Shargh
We describe a unified picture of symmetry-breaking electronic interactions that are usually described as "pseudo Jahn-Teller (PJT) effects" and attributed to vibronic coupling, but can also be associated with hyperconjugative donor-acceptor interactions in the framework of natural bond orbital (NBO) and natural resonance theory (NRT) analysis. We show how NBO/NRT descriptors offer a simplified alternative to the vibronic coupling picture of PJT effects that yields both improved cause-effect specificity and chemically enriched understanding of symmetry-breaking phenomena, but with no necessary input from ground-state vibrational or excited-state electronic properties...
April 19, 2018: Journal of Physical Chemistry. A
Sangah Shin, Eiko Saito, Norie Sawada, Junko Ishihara, Ribeka Takachi, Akiko Nanri, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
PURPOSE: The development of prostate cancer may be impacted by environmental factors, including diet. The aim of this study was to evaluate the association between dietary patterns and risk of prostate cancer in a large prospective cohort study among Japanese men. METHODS: A total of 43,469 men who participated in the Japan Public Health Center-based Prospective Study were followed from 1995 to 1998 to the end of 2012, during which 1,156 cases of prostate cancer were newly identified...
April 18, 2018: Cancer Causes & Control: CCC
Vera P Luther, Rachel Shnekendorf, Lilian M Abbo, Sonali Advani, Wendy S Armstrong, Alice E Barsoumian, Cole B Beeler, Rachel Bystritsky, Kartikeya Cherabuddi, Seth Cohen, Keith W Hamilton, Dilek Ince, Julie Ann Justo, Ashleigh Logan, John B Lynch, Priya Nori, Christopher A Ohl, Payal K Patel, Paul S Pottinger, Brian S Schwartz, Conor Stack, Yuan Zhou
A needs assessment survey of Infectious Diseases (ID) training program directors identified gaps concerning comprehensive and structured educational resources for training and evaluating ID fellows in antimicrobial stewardship. An IDSA-sponsored antimicrobial stewardship core curriculum was subsequently developed to address that need.
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Akiko Nanri, Tetsuya Mizoue, Mitsuhiko Noda, Atsushi Goto, Norie Sawada, Shoichiro Tsugane
AIMS/INTRODUCTION: Menstrual and reproductive factors, including age at menarche, parity, and breastfeeding, have been linked to type 2 diabetes risk. We prospectively investigated the association between these factors and type 2 diabetes risk in a large Japanese cohort. MATERIALS AND METHODS: Participants were 37,511 women aged 45-75 years who participated in the baseline (1990-1993), second (1995-1998), and third surveys (2000-2003) of the Japan Public Health Center-based Prospective Study and who had no history of diabetes at the second survey...
April 18, 2018: Journal of Diabetes Investigation
Naomi Sakon, Kenji Sadamasu, Takayuki Shinkai, Yousuke Hamajima, Hideaki Yoshitomi, Yuki Matsushima, Rika Takada, Fumio Terasoma, Asako Nakamura, Jun Komano, Koo Nagasawa, Hideaki Shimizu, Kazuhiko Katayama, Hirokazu Kimura
Seven foodborne norovirus outbreaks attributable to the GII.P17-GII.17 strain were reported across Japan in 2017, causing illness in a total of 2,094 persons. Nori (dried shredded seaweed) was implicated in all outbreaks and tested positive for norovirus. Our data highlight the stability of norovirus in dehydrated food products.
May 2018: Emerging Infectious Diseases
Simone Mosole, Sandra Zampieri, Sandra Furlan, Ugo Carraro, Stefan Löefler, Helmut Kern, Pompeo Volpe, Alessandra Nori
Physical activity plays an important role in preventing muscle atrophy and chronic diseases in adults and in the elderly. Calcium (Ca2+ ) cycling and activation of specific molecular pathways are essential in contraction-induced muscle adaptation. This study attains human muscle sections and total homogenates prepared from biopsies obtained before (control) and after 9 weeks of training by electrical stimulation (ES) on a group of volunteers. The aim of the study was to investigate about the molecular mechanisms that support functional muscle improvement by ES...
January 2018: Gerontology & Geriatric Medicine
Raffaella Nori, Laura Piccardi, Andrea Maialetti, Mirco Goro, Andrea Rossetti, Ornella Argento, Cecilia Guariglia
The present study has two-fold aims: to investigate whether gender differences persist even when more time is given to acquire spatial information; to assess the gender effect when the retrieval phase requires recalling the pathway from the same or a different reference perspective (egocentric or allocentric). Specifically, we analyse the performance of men and women while learning a path from a map or by observing an experimenter in a real environment. We then asked them to reproduce the learned path using the same reference system (map learning vs...
2018: Frontiers in Neuroscience
Federica Turrini, Raffaella Boggia, Riccardo Leardi, Matilde Borriello, Paola Zunin
'Violet Nori' is a new spontaneous growing violet rice variety showing a peculiar violet color in its fresh leaves as well. In this paper, the antioxidant properties and the content of total phenols, radical scavengers, and anthocyanins in 'Violet Nori' caryopses, flour, and leaves are explored and compared. Ultrasonic-Assisted Extraction (UAE) is employed for the extraction of phenolic compounds, improving the extraction conditions by Design of Experiments (DoE). The obtained results show that the Radical Scavenging Activities (RSAs), the Total Phenolic Contents (TPCs), and the anthocyanin amounts (1000-1500 μg/g, expressed as cyanidin-3-glucoside) of 'Violet Nori' caryopses are higher than those in the other analyzed colored rice samples (300-900 μg/g as cyanidin-3-glucoside), with the exception of the cultivars 'Artemide' and 'Nerone', which show comparable values of RSAs and TPCs...
April 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kazuyuki Nakanishi, Shotaro Uehara, Takashi Kusama, Takashi Inoue, Kanami Shimura, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki, Hiroshi Yamazaki
Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4'-hydroxydiclofenac and minorly by P450 3A4 to 5-hydroxydiclofenac that leads to reactive intermediates. In this study, in vivo pharmacokinetics in six marmosets and in vitro metabolism in nine marmoset liver microsomes were analyzed using diclofenac to evaluate marmosets as preclinical drug metabolism models...
April 4, 2018: Biochemical Pharmacology
Norie Murayama, Hiroshi Yamazaki
Hepatocyte-like cells differentiated from human induced pluripotent stem (iPS) cells are of great interest for applications in pharmacological research. For drug metabolism testing, commercially available hepatocytes derived from human iPS cells are generally recommended to be used 1 week after seeding on plates. In this study, however, after 3-4 weeks of culture according to the manufacturer's instructions, human cytochrome P450 (P450) 2C9- and 2C19-dependent diclofenac 4'-hydroxylation and omeprazole 5-hydroxylation activities of the iPS-derived hepatocytes had significantly increased above the activities at 1 week and had reached levels similar to those in HepaRG cells, a human hepatocyte-like cell line...
2018: Journal of Toxicological Sciences
Hidejiro Kawahara, Takashi Mouri, Kota Ishida, Nori Matsumoto, Tadashi Akiba, Katsuhiko Yanaga
BACKGROUND/AIM: The feasibility and oncological outcomes of treatment with TAS-102, that is recommended as third-line chemotherapy for patients with metastatic colorectal cancer (mCRC), remain unknown. PATIENTS AND METHODS: Between 2013 and 2015, seven patients (five males, two females) with mCRC who were administered TAS-102 as third-line chemotherapy at our Institution were retrospectively studied. During the same period, seven patients with mCRC with Kirsten rat sarcoma viral oncogene homolog (KRAS) wild-type primary lesions who were administered irinotecan with panitumumab comprised the control group...
April 2018: Anticancer Research
Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama, Ken Ninomiya, Junichi Yamane, Kazuya Kitamura, Seiji Ueda
Sufficient width of laminectomy or laminoplasty is considered a criterion for successful surgical outcomes following posterior cervical decompression. No previous study has focused on surgical outcomes achieved by wide versus narrow decompression. This study examined whether narrow laminectomy width (LW) affected surgical outcomes in cervical compressive myelopathy (CCM). Between 2005 and 2010, we performed muscle-preserving selective laminectomy (SL) with decompression between the bilateral medial margin of the facet joints (wide SL)...
March 26, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Nori Sato, Kosaku Higashino, Toshinori Sakai, Tomoya Terai, Vijay K Goel, Ashok Biyani, Nabil Ebraheim, Yoichiro Takata, Fumio Hayashi, Kazuta Yamashita, Masatoshi Morimoto, Hiroaki Manabe, Koichi Sairyo
Ligamentum flavum (LF) hypertrophy is one of the main factors of lumbar spinal canal stenosis (LSCS). The primary object of this study is to clarify the existence of epiligament in the LF and its role in hypertrophy, and to develop an LF hypertrophy animal model. A cadaveric spine from a 30-year-old man was used to investigate the existence of epiligament in LF. Five LF samples from LSCS patients were obtained to evaluate hypertrophied LF. To create a rat model, we destabilized the lumbar spine. Each LF was sagittally cut for histological evaluation...
2018: Journal of Medical Investigation: JMI
Nori Sato, Naomi Hase, Akemi Osaka, Koichi Sairyo, Shinsuke Katoh
Falls cause injuries such as fractures, skin lacerations, bleeding, and head injury, and could result in more severe medical conditions in hospitalized patients. We retrospectively investigated the incidence and characteristics of falls among hospitalized patients in an acute care hospital from incident reports by hospital staff between January and June 2013. There were 154 falls in 135 patients, 2 of which resulted in fracture. The average age of patients who fell was 63.9 (range 0 to 91) years. Many falls occurred at the bedside (68...
2018: Journal of Medical Investigation: JMI
Paul T Engels, Nori L Bradley, Chad G Ball
General surgeons provide life-saving trauma care to a large portion of Canadians. Although trauma care has evolved significantly over the last few decades and now requires fewer operations, when a life-saving operation is required the expectation of competence to perform this operation has not been reduced. A recent study from the United States found decreased resident case-log volumes of trauma operations. Such findings raise the alarm of declining exposure of residents to trauma operations and beg the question of whether graduating residents are competent to care for trauma patients...
April 1, 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Junya Sado, Tetsuhisa Kitamura, Tomotaka Sobue, Norie Sawada, Motoki Iwasaki, Shizuka Sasazuki, Taiki Yamaji, Taichi Shimazu, Shoichiro Tsugane
Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer incidence in Western countries. However, few epidemiological studies have assessed the association between anthropometric factors, such as BMI, height, or weight, and thyroid cancer incidence in Asian populations. Using the population-based Japan Public Health Center-based prospective study database, we investigated the relationship between anthropometric factors and thyroid cancer incidence. Data on anthropometric factors were collected through a self-administered questionnaire at baseline...
March 25, 2018: Cancer Medicine
Takashi Nakagawa, Takashi Kobayashi, Shin Nishiumi, Akihisa Hidaka, Taiki Yamaji, Norie Sawada, Yuichi Hirata, Kodai Yamanaka, Takeshi Azuma, Atsushi Goto, Taichi Shimazu, Manami Inoue, Motoki Iwasaki, Masaru Yoshida, Shoichiro Tsugane
Discovery of the high risk group of pancreatic cancer is important for prevention of pancreatic cancer. This study was conducted in a nested case-control study including 170 pancreatic cancer cases and 340 matched controls of our population-based cohort study involving 30,239 subjects who answered a baseline questionnaire and supplied blood samples. The 12 targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry. The odds ratios and their corresponding 95% confidence intervals were calculated using conditional logistic regression models...
March 25, 2018: Cancer Science
Icro Meattini, Donato Pezzulla, Calogero Saieva, Marco Bernini, Lorenzo Orzalesi, Luis Jose Sanchez, Isacco Desideri, Giulio Francolini, Pierluigi Bonomo, Daniela Greto, Mauro Loi, Monica Mangoni, Alessio Bruni, Jacopo Nori, Vania Vezzosi, Simonetta Bianchi, Lorenzo Livi
BACKGROUND: Invasive triple negative apocrine carcinoma (TNAC) of the breast is a rare type of triple negative breast cancer. Several studies reported significantly distinct prognosis for TNAC when compared with most of the non-apocrine triple negative (NATN) tumors. This is a case-control study reporting onoutcomes from our long-term single-center experience. PATIENTS AND METHODS: We analyzed the clinicopathologic features of a series of 46 TNAC tumors treated in a 15-year period...
March 2, 2018: Clinical Breast Cancer
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