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https://www.readbyqxmd.com/read/28447605/traumatic-spinal-cord-injury
#1
REVIEW
Christopher S Ahuja, Jefferson R Wilson, Satoshi Nori, Mark R N Kotter, Claudia Druschel, Armin Curt, Michael G Fehlings
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and initiates a secondary injury cascade that leads to progressive cell death and spinal cord damage over the subsequent weeks. Over time, the lesion remodels and is composed of cystic cavitations and a glial scar, both of which potently inhibit regeneration...
April 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28446545/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association-between-fruit-vegetable-and-mature-bean-consumption-and-risk-of-prostate-cancer
#2
Joshua Petimar, Kathryn M Wilson, Kana Wu, Molin Wang, Demetrius Albanes, Piet A van den Brandt, Michael B Cook, Graham G Giles, Edward L Giovannucci, Gary G Goodman, Phyllis J Goodman, Niclas Håkansson, Kathy Helzlsouer, Timothy J Key, Laurence N Kolonel, Linda M Liao, Satu Männistö, Marjorie L McCullough, Roger L Milne, Marian L Neuhouser, Yikyung Park, Elizabeth A Platz, Elio Riboli, Norie Sawada, Jeannette M Schenk, Shoichiro Tsugane, Bas Verhage, Ying Wang, Lynne R Wilkens, Alicja Wolk, Regina G Ziegler, Stephanie A Smith-Warner
BACKGROUND: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. METHODS: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28445513/dietary-patterns-and-all-cause-cancer-and-cardiovascular-disease-mortality-in-japanese-men-and-women-the-japan-public-health-center-based-prospective-study
#3
Akiko Nanri, Tetsuya Mizoue, Taichi Shimazu, Junko Ishihara, Ribeka Takachi, Mitsuhiko Noda, Hiroyasu Iso, Shizuka Sasazuki, Norie Sawada, Shoichiro Tsugane
OBJECTIVE: A meta-analysis showed an inverse association of a prudent/healthy dietary pattern with all-cause mortality and no association of a western/unhealthy dietary pattern. However, the association of distinctive dietary patterns of Japanese population with mortality remains unclear. We prospectively investigated the association between dietary patterns and all-cause, cancer, and cardiovascular disease mortality among Japanese adults. METHODS: Participants were 36,737 men and 44,983 women aged 45-74 years who participated in the second survey of the Japan Public Health Center-based Prospective Study (1995-1998) and who had no history of serious disease...
2017: PloS One
https://www.readbyqxmd.com/read/28418813/radiation-induced-deletions-in-mouse-spermatogonia-are-usually-large-over-200-kb-and-contain-little-sequence-similarity-at-the-junctions
#4
Mieko Kodaira, Jun-Ichi Asakawa, Nori Nakamura
Ionizing radiation can induce mutations, and the majority of radiation-induced mutations in mammalian cells are deletions. The most critical types of radiation-induced DNA damage are DNA double-strand breaks, and these breaks are repaired by either the homologous recombination (HR) pathway or the non-homologous end joining (NHEJ) pathway. The HR pathway is not as mutagenic as the NHEJ pathway, and it is expected that radiation-induced deletions would usually have little sequence similarity around the deletion junction points...
April 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/28411212/insights-into-the-effects-of-complement-factor-h-on-the-assembly-and-decay-of-the-alternative-pathway-c3-proconvertase-and-c3-convertase
#5
Serena Bettoni, Elena Bresin, Giuseppe Remuzzi, Marina Noris, Roberta Donadelli
No abstract text is available yet for this article.
April 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28407551/plasma-adiponectin-levels-adipoq-variants-and-incidence-of-type-2-diabetes-a-nested-case-control-study
#6
Atsushi Goto, Mitsuhiko Noda, Maki Goto, Kazuki Yasuda, Tetsuya Mizoue, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
AIMS: To clarify the associations between plasma adiponectin levels and ADIPOQ variants with type 2 diabetes incidence in a general Japanese population. METHODS: We conducted a case-control study nested within the Japan Public Health Center-based Prospective Study. We measured plasma adiponectin levels and genotyped +45T>G (rs2241766) and +276G>T (rs1501299) in the ADIPOQ gene among 417 incident diabetes cases and 1197 control subjects matched by age, sex, and area...
March 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28406897/changes-in-the-living-arrangement-and-risk-of-stroke-in-japan-does-it-matter-who-lives-in-the-household-who-among-the-family-matters
#7
Ehab Salah Eshak, Hiroyasu Iso, Kaori Honjo, Ai Noda, Norie Sawada, Shoichiro Tsugane
Previous studies have suggested associations of family composition with morbidity and mortality; however, the evidence of associations with risk of stroke is limited. We sought to examine the impact of changes in the household composition on risk of stroke and its types in Japanese population. Cox proportional hazard modelling was used to assess the risk of incident stroke and stroke types within a cohort of 77,001 Japanese men and women aged 45-74 years who experienced addition and/or loss of family members [spouse, child(ren), parent(s) and others] to their households over a five years interval (between 1990-1993 and 1995-1998)...
2017: PloS One
https://www.readbyqxmd.com/read/28406526/changes-in-the-nutritional-quality-of-five-mangifera-species-harvested-in-two-maturity-stages
#8
Ignacio Barbosa Gámez, Karla P Caballero Montoya, Noris Ledesma, Sonia G Sáyago Ayerdi, María de Lourdes Gacía-Magaña, Eric J von Wettberg, Efigenia Montalvo-González
BACKGROUND: There are 69 species of edible Mangifera recognized in Southeast Asia. Most of these species have not been characterized for nutritional properties. Here we describe the nutritional quality of the pulp of several Mangifera species: Mangifera casturi, Mangifera lalijiwa, Mangifera odorata, Mangifera zeylanica and two cultivars of Mangifera indica 'Tommy-Kent' and 'Tommy Atkins' at two maturity stages. RESULTS: The results show that nutritional quality varied with the maturity stage and among the species...
April 13, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28400079/smoking-and-subsequent-risk-of-leukemia-in-japan-the-japan-public-health-center-based-prospective-study
#9
Tomotaka Ugai, Keitaro Matsuo, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
BACKGROUND: Cigarette smoking has been reported to be associated with an increased risk of leukemia. Most epidemiological evidence on the association between cigarette smoking and leukemia risk is from studies conducted in Western populations, however, and evidence from Asian populations is scarce. METHODS: We conducted a large-scale population-based cohort study of 96,992 Japanese subjects (46,493 men and 50,499 women; age 40-69 years at baseline) with an average 18...
April 8, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28386039/changes-in-the-employment-status-and-risk-of-stroke-and-stroke-types
#10
Ehab S Eshak, Kaori Honjo, Hiroyasu Iso, Ai Ikeda, Manami Inoue, Norie Sawada, Shoichiro Tsugane
BACKGROUND AND PURPOSE: Because of limited evidence, we investigated a long-term impact of changes in employment status on risk of stroke. METHODS: This was a prospective study of 21 902 Japanese men and 19 826 women aged 40 to 59 years from 9 public health centers across Japan. Participants were followed up from 1990 to 1993 to the end of 2009 to 2014. Cox proportional hazard ratio of stroke (incidence and mortality) and its types (hemorrhagic and ischemic) was calculated according to changes in the employment status within 5 years interval between 1990 to 1993 and 1995 to 1998 (continuously employed, job loss, reemployed, and continuously unemployed)...
April 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28385783/bleeding-risk-of-surgery-and-its-prevention-in-patients-with-inherited-platelet-disorders-the-surgery-in-platelet-disorders-and-therapeutic-approach-spata-study
#11
Sara Orsini, Patrizia Noris, Loredana Bury, Paula G Heller, Cristina Santoro, Rezan A Kadir, Nora C Butta, Emanuela Falcinelli, Ana Rosa Cid, Fabrizio Fabris, Marc Fouassier, Koji Miyazaki, Maria Luisa Lozano, Pamela Zuñiga, Claire Flaujac, Gian Marco Podda, Nuria Bermejo, Remi Favier, Yvonne Henskens, Emmanuel De Maistre, Erica De Candia, Andrew D Mumford, Nihal G Ozdemir, Ibrahim Eker, Paquita Nurden, Sophie Bayart, Michele P Lambert, James Bussel, Barbara Zieger, Alberto Tosetto, Federica Melazzini, Ana C Glembotsky, Alessandro Pecci, Marco Cattaneo, Nicole Schlegel, Paolo Gresele
Excessive bleeding at surgery is a feared complication in patients with inherited platelet disorders (IPD), however very few studies have evaluated the frequency of surgical bleeding in these hemorrhagic disorders. We performed a multicentric, retrospective worldwide study to assess the bleeding complications of surgery, the preventive and therapeutic approaches adopted and their efficacy in patients with IPDs by rating the outcome of 829 surgical procedures carried out in 423 patients with well defined forms of IPD (238 inherited platelet function disorders -IPFD- and 185 inherited platelet number disorders-IPND-)...
April 6, 2017: Haematologica
https://www.readbyqxmd.com/read/28384565/impact-of-hormonal-status-on-outcome-of-ductal-carcinoma-in-situ-treated-with-breast-conserving-surgery-plus-radiotherapy-long-term-experience-from-two-large-institutional-series
#12
Icro Meattini, Calogero Saieva, Paolo Bastiani, Francesca Martella, Giulio Francolini, Monica Lo Russo, Lisa Paoletti, Morena Doria, Isacco Desideri, Francesca Terziani, Carla De Luca Cardillo, Benedetta Bendinelli, Cinzia Ciabatti, Cristina Muntoni, Galliano Tinacci, Jacopo Nori, Herd Smith, Beniamino Brancato, Lorenzo Galli, Luis Jose Sanchez, Donato Casella, Marco Bernini, Lorenzo Orzalesi, Giulio Alberto Carta, Simonetta Bianchi, Francesca Rossi, Lorenzo Livi
BACKGROUND: Ductal carcinoma in situ (DCIS) is a heterogeneous disease, for which the best adjuvant treatment is still uncertain. Many attempts of risk-groups stratification have been made over time, developing prognostic scores to predict risk of local recurrence (LR) on the basis of features such as age, final surgical margins (FSM) status, grade, and tumor size. The aim of our analysis was to evaluate the patterns of recurrence from a two large-institutional retrospective series. PATIENTS AND METHODS: We collected data on 457 patients treated with BCS and adjuvant RT between 1990 and 2012...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28381528/cruciferous-vegetable-intake-is-inversely-associated-with-lung-cancer-risk-among-current-nonsmoking-men-in-the-japan-public-health-center-study
#13
Nagisa Mori, Taichi Shimazu, Shizuka Sasazuki, Miho Nozue, Michihiro Mutoh, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Manami Inoue, Ribeka Takachi, Ayaka Sunami, Junko Ishihara, Tomotaka Sobue, Shoichiro Tsugane
Background: Cruciferous vegetables, a rich source of isothiocyanates, have been reported to lower the risk of several types of cancer, including lung cancer. However, evidence from prospective observations of populations with a relatively high intake of cruciferous vegetables is sparse.Objective: We investigated the association between cruciferous vegetable intake and lung cancer risk in a large-scale population-based prospective study in Japan.Methods: We studied 82,330 participants (38,663 men; 43,667 women) aged 45-74 y without a past history of cancer...
April 5, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28368947/female-reproductive-factors-exogenous-hormone-use-and-pancreatic-cancer-risk-the-japan-public-health-center-based-prospective-study
#14
Yvonne Teng, Eiko Saito, Sarah K Abe, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
An association between female reproductive factors, exogenous hormone use, and pancreatic cancer risk has long been suggested in laboratory settings, but epidemiological findings remain mixed and inconclusive. Studies carried out on Asian populations are also limited. In this study, 45 617 women aged 40-69 years were followed for an average of 18.4 years in the Japan Public Health Center-based prospective cohort and 211 pancreatic cases were identified as of 31 December 2011. We applied multivariate-adjusted Cox proportional hazards regression models using age as a time-scale to assess the association between female reproductive factors (menstrual status, menarche age, menopause age, number of births, age at first birth, total years of fertility, history of breastfeeding) and exogenous hormone use with the incidence of pancreatic cancer through hazard ratios and confidence intervals...
March 31, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28364620/a-personality-based-latent-class-typology-of-outpatients-with-major-depressive-disorder-association-with-symptomatology-prescription-pattern-and-social-function
#15
Hiroaki Hori, Toshiya Teraishi, Anna Nagashima, Norie Koga, Miho Ota, Kotaro Hattori, Yoshiharu Kim, Teruhiko Higuchi, Hiroshi Kunugi
BACKGROUND: While major depressive disorder (MDD) is considered to be a heterogeneous disorder, the nature of the heterogeneity remains unclear. Studies have attempted to classify patients with MDD using latent variable techniques, yet the empirical approaches to symptom-based subtyping of MDD have not provided conclusive evidence. Here we aimed to identify homogeneous classes of MDD based on personality traits, using a latent profile analysis. METHODS: We studied 238 outpatients with DSM-IV MDD recruited from our specialized depression outpatient clinic and assessed their dimensional personality traits with the Temperament and Character Inventory...
March 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28362652/the-association-between-plasma-c-peptide-concentration-and-the-risk-of-prostate-cancer-a-nested-case-control-study-within-a-japanese-population-based-prospective-study
#16
Grace Y Kiyabu, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
The association between plasma C-peptide concentration and prostate cancer is unclear. Inconsistency of results from previous studies motivates this study. Using the Japan Public Health Center-based Prospective study, 201 prostate cancer cases and 402 controls were matched by age, public health center area, residence, date and time of blood collection, and fasting duration before blood collection. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated by conditional logistic regression models. Out of 201 cases, 144 were localized and 48 were advanced...
March 30, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28357622/the-attribution-of-intentionality-the-role-of-skill-and-morality
#17
Raffaella Nori, Elisa Gambetti, Fabio Marinello, Stefano Canestrari, Fiorella Giusberti
The present study contributes to the discussion on the different components which constitute the intentionality concept about an undesired side effect, focusing on the morality and the skill. Two hundred and forty participants were asked to read a brief story about a car accident, in which it was explained the motivation of the high speed and objective and subjective skill of the agent to drive the car, and to fill in six questions about intentionality, objective risk, mental representation of risk, risk acceptance and blameworthiness for the outcome...
March 29, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28350947/traumatic-spinal-cord-injury-repair-and-regeneration
#18
Christopher S Ahuja, Satoshi Nori, Lindsay Tetreault, Jefferson Wilson, Brian Kwon, James Harrop, David Choi, Michael G Fehlings
BACKGROUND: Traumatic spinal cord injuries (SCI) have devastating consequences for the physical, financial, and psychosocial well-being of patients and their caregivers. Expediently delivering interventions during the early postinjury period can have a tremendous impact on long-term functional recovery. PATHOPHYSIOLOGY: This is largely due to the unique pathophysiology of SCI where the initial traumatic insult (primary injury) is followed by a progressive secondary injury cascade characterized by ischemia, proapoptotic signaling, and peripheral inflammatory cell infiltration...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28345093/diffusion-of-active-dimers-in-a-couette-flow
#19
Tanwi Debnath, Pulak K Ghosh, Franco Nori, Yunyun Li, Fabio Marchesoni, Baowen Li
We study the 3D dynamics of an elastic dimer consisting of an active swimmer bound to a passive cargo, both suspended in a Couette flow. Using numerical simulations, we determine the diffusivity of such an active dimer in the presence of long-range hydrodynamic interactions for different values of its self-propulsion speed and the Couette flow. We observe that the effect of hydrodynamic interactions is greatly enhanced under the condition that self-propulsion is strong enough to contrast the shear flow. The magnitude of the effect grows with the size of the dimer's constituents relative to their distance, which makes it appreciable under experimental conditions...
April 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28337559/dietary-fiber-intake-and-risk-of-breast-cancer-defined-by-estrogen-and-progesterone-receptor-status-the-japan-public-health-center-based-prospective-study
#20
Saki Narita, Manami Inoue, Eiko Saito, Sarah K Abe, Norie Sawada, Junko Ishihara, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Kenji Shibuya, Shoichiro Tsugane
PURPOSE: Epidemiological studies have suggested a protective effect of dietary fiber intake on breast cancer risk while the results have been inconsistent. Our study aimed to investigate the association between dietary fiber intake and breast cancer risk and to explore whether this association is modified by reproductive factors and hormone receptor status of the tumor. METHODS: A total of 44,444 women aged 45 to 74 years from the Japan Public Health Center-based Prospective Study were included in analyses...
March 23, 2017: Cancer Causes & Control: CCC
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