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https://www.readbyqxmd.com/read/28729251/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#1
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loic Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazard model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28724849/the-ilizarov-mini-external-fixator-for-the-treatment-of-first-metatarsal-fracture-a-case-report
#2
Tatsunori Kataoka, Norie Kodera, Shinro Takai
Forefoot fractures are frequently accompanied by severe soft tissue damage. Therefore, treatment should focus not only on fractures but also on soft tissue damage, for which external fixation can be used as a surgical option. A 63-year-old woman presented to the emergency clinic of our hospital with forefoot pain after a motorcycle accident. Comminuted fracture of the proximal part of the metatarsal was diagnosed. Because of the swollen foot and fracture comminution, an operation using the Ilizarov mini external fixator was performed to prevent further damage to the soft tissue...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28724661/fermented-soy-product-intake-is-inversely-associated-with-the-development-of-high-blood-pressure-the-japan-public-health-center-based-prospective-study
#3
Miho Nozue, Taichi Shimazu, Shizuka Sasazuki, Hadrien Charvat, Nagisa Mori, Michihiro Mutoh, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Manami Inoue, Yoshihiro Kokubo, Kazumasa Yamagishi, Hiroyasu Iso, Shoichiro Tsugane
Background: Randomized controlled studies have investigated the short-term effect of soy product intake on blood pressure (BP) in normotensive people. To our knowledge, no prospective studies exist on the effect of habitual intake of fermented soy products, separate from total soy products, on BP in the general population.Objective: We examined the association between the habitual intake of soy products, including fermented soy products, and the development of high BP during a 5-y period among participants in a population-based prospective cohort study in Japan...
July 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28714213/smoking-and-alcohol-and-subsequent-risk-of-myelodysplastic-syndromes-in-japan-the-japan-public-health-centre-based-prospective-study
#4
Tomotaka Ugai, Keitaro Matsuo, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Yoshinobu Kanda, Shoichiro Tsugane
Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes (MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40-69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up...
July 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28714088/pressure-based-alkaline-lysis-with-immunocapture-a-method-for-enhanced-recovery-in-differential-extraction
#5
Vanessa Martinez, Deepthi Nori, Pero Dimsoski, Bruce McCord
A pressure based protocol for differential extraction has been optimized to provide a rapid and selective alternative to conventional differential extraction techniques with the advantage of an increased recovery of genomic DNA. The protocol involves treating cotton swabs containing mixtures of sperm and vaginal epithelial cells with 2 sets of pressure treatment using a Barocycler(®) NEP 2320 in alkaline conditions. This first step quantitatively and selectively removes female epithelial cells. The cotton swab is removed and further treated with alkali at 95°C for the removal of sperm cell DNA...
July 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28711185/dosimetric-characterization-of-3d-printed-bolus-at-different-infill-percentage-for-external-photon-beam-radiotherapy
#6
Rosalinda Ricotti, Delia Ciardo, Floriana Pansini, Alessia Bazani, Stefania Comi, Ruggero Spoto, Samuele Noris, Federica Cattani, Guido Baroni, Roberto Orecchia, Andrea Vavassori, Barbara Alicja Jereczek-Fossa
BACKGROUND AND PURPOSE: 3D printing is rapidly evolving and further assessment of materials and technique is required for clinical applications. We evaluated 3D printed boluses with acrylonitrile butadiene styrene (ABS) and polylactide (PLA) at different infill percentage. MATERIAL AND METHODS: A low-cost 3D printer was used. The influence of the air inclusion within the 3D printed boluses was assessed thoroughly both with treatment planning system (TPS) and with physical measurements...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28706251/frequency-conversion-in-ultrastrong-cavity-qed
#7
Anton Frisk Kockum, Vincenzo Macrì, Luigi Garziano, Salvatore Savasta, Franco Nori
We propose a new method for frequency conversion of photons which is both versatile and deterministic. We show that a system with two resonators ultrastrongly coupled to a single qubit can be used to realise both single- and multiphoton frequency-conversion processes. The conversion can be exquisitely controlled by tuning the qubit frequency to bring the desired frequency-conversion transitions on or off resonance. Considering recent experimental advances in ultrastrong coupling for circuit QED and other systems, we believe that our scheme can be implemented using available technology...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694472/the-pawnee-earthquake-as-a-result-of-the-interplay-among-injection-faults-and-foreshocks
#8
Xiaowei Chen, Nori Nakata, Colin Pennington, Jackson Haffener, Jefferson C Chang, Xiaohui He, Zhongwen Zhan, Sidao Ni, Jacob I Walter
The Pawnee M5.8 earthquake is the largest event in Oklahoma instrument recorded history. It occurred near the edge of active seismic zones, similar to other M5+ earthquakes since 2011. It ruptured a previously unmapped fault and triggered aftershocks along a complex conjugate fault system. With a high-resolution earthquake catalog, we observe propagating foreshocks leading to the mainshock within 0.5 km distance, suggesting existence of precursory aseismic slip. At approximately 100 days before the mainshock, two M ≥ 3...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691388/topical-treatment-with-sacran-a-sulfated-polysaccharide-from-aphanothece-sacrum-improves-corneocyte-derived-parameters
#9
Moeko Doi, Yuki Sagawa, Shigeyoshi Momose, Takumi Tanaka, Taeko Mizutani, Yuri Okano, Hitoshi Masaki
Sacran, a polysaccharide isolated from Aphanothece sacrum (Suizenji-nori) alga, has unique characteristics in terms of its physiological properties and effects on the skin, and has recently become a focus of attention as a novel biomaterial. In a previous study, we reported the unique physical characteristics of sacran, which forms a gel-like film containing water in the presence of polyols. This film resists penetration by water and chemicals. We expected this unique physical characteristic to act as an artificial barrier upon the application of sacran to the skin...
July 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28681440/smoking-and-subsequent-risk-of-acute-myeloid-leukaemia-a-pooled-analysis-of-9-cohort-studies-in-japan
#10
Tomotaka Ugai, Keitaro Matsuo, Isao Oze, Hidemi Ito, Kenji Wakai, Keiko Wada, Chisato Nagata, Tomio Nakayama, Rong Liu, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Norie Sawada, Atsuko Sadakane, Keitaro Tanaka, Tetsuya Mizoue, Manami Inoue, Shoichiro Tsugane, Taichi Shimazu
Smoking has been identified as a significant risk factor for acute myeloid leukaemia (AML). However, epidemiological evidence for the effect of smoking on the risk of AML among Asians is scarce. Here, we investigated the impact of smoking habits on the risk of AML by conducting a pooled analysis of 9 population-based prospective cohort studies in Japan. We analysed original data on smoking habits at baseline from 9 cohort studies. Hazard ratios (HRs) in the individual studies were calculated using a Cox proportional hazard model adjusted for potential confounders and combined using a random-effects model...
July 6, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28679270/sound-propagation-in-porous-materials-with-annular-pores
#11
Massimiliano Nori, Rodolfo Venegas
Long-wavelength sound propagation in porous materials with annular pores is investigated in this paper. Closed-form analytical expressions for the effective acoustical properties of this type of material were obtained. These are compared with both direct numerical calculations of the effective properties and their calculations obtained by using semi-phenomenological models. Analytical expressions for the input parameters of the latter, i.e., static viscous and thermal permeabilities, viscous and thermal characteristic lengths, and tortuosity, are also provided...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28674278/genetic-characterization-and-fine-mapping-of-s25-a-hybrid-male-sterility-gene-on-rice-chromosome-12
#12
Takahiko Kubo, Atsushi Yoshimura, Nori Kurata
Hybrid male sterility genes are important factors in creating postzygotic reproductive isolation barriers in plants. One such gene, S25, is known to cause severe transmission ratio distortion in inter-subspecific progeny of cultivated rice Oryza sativa ssp. indica and japonica. To further characterize the S25 gene, we fine-mapped and genetically characterized the S25 gene using near-isogenic lines with reciprocal genetic backgrounds. We mapped the S25 locus within a 0.67-1.02 Mb region on rice chromosome 12...
June 30, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28664631/avian-gametologs-as-molecular-tags-for-sex-identification-in-birds-of-prey-of-iran
#13
Reza Valadan, Foroogh Nejatollahi, Hoda Ehsani-Nori, Hassan Habibi, Hamid Amini, Mansour Aliabadian
Global environmental change and rapid destruction of natural habitats necessitate the conservation of endangered and threatened birds of prey. Recently, molecular sex identification methods based on amplification of introns of chromodomain-helicase DNA binding protein1 (CHD1) have provided valuable tools for ecological study and conservation breeding programs of birds. These methods employ a primer pair flanking an intron which varies considerably in length between the avian gametologs CHD1Z and CHD1W. Herein, we test the applicability of CHD1Z and CHD1W as universal tags for molecular sex identification in birds of prey of Iran...
June 30, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28661674/exploring-the-origin-of-the-generalized-anomeric-effects-in-the-acyclic-nonplanar-systems
#14
Neda Hasanzadeh, Davood Nori-Shargh, Hooriye Yahyaei, Seiedeh Negar Mousavi, Sahar Kamrava
Contrary to the published conclusions in the literature concerning the origin of the generalized anomeric relationships in open-chain nonplanar systems, its origin has remained an open question. In order to explore the origin of the generalized anomeric relationships in open-chain nonplanar systems, we assessed the roles and contributions of the effective factors on the conformational properties of methyl propargyl ether (1), methyl propargyl sulfide (2), and methyl propargyl selenide (3) by means of the G3MP2, CCSD(T), MP2, LC-ωPBE, and B3LYP methods and natural bond orbital (NBO) interpretations...
July 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28660373/cervical-laminectomy-of-limited-width-prevents-postoperative-c5-palsy-a-multivariate-analysis-of-263-muscle-preserving-posterior-decompression-cases
#15
Satoshi Nori, Ryoma Aoyama, Ken Ninomiya, Junichi Yamane, Kazuya Kitamura, Seiji Ueda, Tateru Shiraishi
PURPOSE: Between 2006 and 2010, we performed wide laminectomy (wide LAM) alone, with decompression performed between the bilateral medial margin of the zygapophyseal joints, or double-door laminoplasty (DL) combined with wide LAM for cervical compressive myelopathy (CCM). From 2010, instead of wide LAM and DL, we began to perform narrow LAM, where the laminectomy width was no more than 2-3 mm wider than the spinal cord width (SW). This study aimed to elucidate the risk factors for C5 palsy by reviewing surgical outcomes...
June 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28658043/impact-of-cervical-spine-deformity-on-pre-operative-disease-severity-and-post-operative-outcomes-following-fusion-surgery-for-degenerative-cervical-myelopathy-sub-analysis-of-aospine-north-america-and-international-studies
#16
So Kato, Aria Nouri, Dongjin Wu, Satoshi Nori, Lindsay Tetreault, Michael G Fehlings
STUDY DESIGN: Sub-analysis of the prospective AOSpine CSM North America and International studies. OBJECTIVE: To investigate the impact of cervical spine deformity on pre- and post-operative outcomes in fusion surgeries for degenerative cervical myelopathy. SUMMARY OF BACKGROUND DATA: The associations between cervical alignment and patient outcomes have been reported but are not well established in a myelopathy cohort. The impact of deformity correction in this population also needs to be elucidated...
June 27, 2017: Spine
https://www.readbyqxmd.com/read/28656278/semaphorin-4d-promotes-bone-invasion-in-head-and-neck-squamous-cell-carcinoma
#17
Hiroyuki Takada, Soichiro Ibaragi, Takanori Eguchi, Tatsuo Okui, Kyoichi Obata, Masanori Masui, Ayaka Morisawa, Kiyofumi Takabatake, Hotaka Kawai, Norie Yoshioka, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Guo-Fu Hu, Hitoshi Nagatsuka, Akira Sasaki
Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in the bone microenvironment and many cancer tissues including HNSCC. To date, however, the role of Sema4D in cancer-associated bone disease is still unknown. This is the first study to demonstrate the role of Sema4D in bone invasion of cancer. In the clinical tissue samples of bone lesion of HNSCC, Sema4D was detected at high levels, and its expression was correlated with insulin-like growth factor-I (IGF-I) expression...
June 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28652401/interaction-between-multimeric-von-willebrand-factor-and-complement-a-fresh-look-to-the-pathophysiology-of-microvascular-thrombosis
#18
Serena Bettoni, Miriam Galbusera, Sara Gastoldi, Roberta Donadelli, Chiara Tentori, Giuseppina Spartà, Elena Bresin, Caterina Mele, Marta Alberti, Agustin Tortajada, Hugo Yebenes, Giuseppe Remuzzi, Marina Noris
von Willebrand factor (VWF), a multimeric protein with a central role in hemostasis, has been shown to interact with complement components. However, results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who cannot cleave VWF multimers because of genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement and its pathophysiological implications for human diseases. Using assays of ex vivo serum-induced C3 and C5b-9 deposits on endothelial cells, we documented that in cTTP, complement is activated via the alternative pathway (AP) on the cell surface...
June 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28648140/oxidation-of-1-chloropyrene-by-human-cyp1-family-and-cyp2a-subfamily-cytochrome-p450-enzymes-catalytic-roles-of-two-cyp1b1-and-five-cyp2a13-allelic-variants
#19
Tsutomu Shimada, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Young-Ran Lim, Sora Yeom, Donghak Kim, Hiroshi Yamazaki, F Peter Guengerich, Masayuki Komori
1. 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic two CYP1B1 and five CYP2A13 allelic variants were also examined. 2. CYP1A1 oxidized 1-chloropyrene at the 6- and 8-positions more actively than at the 3-position, while both CYP1B1.1 and 1B1.3 preferentially catalyzed 6-hydroxylation...
July 21, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28637403/experiences-with-99mtc-hmpao-in-a-diagnostic-pathway-for-violent-patients-with-schizophrenic-spectrum-disorders
#20
Morten Jacobsen, Arvid Jensen, Guttorm Breivik Storvestre, Tone Marie Bergstrom, Diyar Nori Mohamad Rashi, Nielssen Bjorn, Wiktor Pal, Hymer Knut-Erik
Background and objective In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence. Methods Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence. Results All violent patients had areas with reduced accumulation of 99mTc-HMPAO frontally and in the temporal lobe, in the non-violent group only two patients demonstrated these findings...
June 21, 2017: Current Radiopharmaceuticals
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