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tocotrienols

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https://www.readbyqxmd.com/read/29157827/supplementation-with-tocotrienols-from-bixa-orellana-improves-the-in-vivo-efficacy-of-daptomycin-against-methicillin-resistant-staphylococcus-aureus-in-a-mouse-model-of-infected-wound
#1
Elisa Pierpaoli, Fiorenza Orlando, Oscar Cirioni, Oriana Simonetti, Andrea Giacometti, Mauro Provinciali
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of skin and soft-tissue infection worldwide. An adequate immune response acts as a first line of defence against infections and therefore plays an essential role in the maintenance of health. Tocotrienols (T3s), the lesser known isomers of vitamin E, possess many biological properties and have been recognized as immunomodulators. PURPOSE: The aim of this study was to investigate whether the in vivo supplementation with a mixture of 87...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156559/tocotrienols-a-family-of-molecules-with-specific-biological-activities
#2
REVIEW
Raffaella Comitato, Roberto Ambra, Fabio Virgili
Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, β-, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorption in deficient rodents or the development of encephalomalacia in chickens. In humans, Vitamin E activity is generally considered to be solely related to the antioxidant properties of the tocolic chemical structure...
November 18, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29147700/brown-rice-and-retrograded-brown-rice-alleviate-inflammatory-response-in-dextran-sulfate-sodium-dss-induced-colitis-mice
#3
Kemika Praengam, Yuraporn Sahasakul, Piengchai Kupradinun, Siriwan Sakarin, Wanwisa Sanitchua, Anudep Rungsipipat, Kasem Rattanapinyopituk, Pornpimon Angkasekwinai, Khaimuk Changsri, Wuttichai Mhuantong, Sithichoke Tangphatsornruang, Siriporn Tuntipopipat
The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white rice (WR), BR and R-BR powder. The mice were divided into 4 groups and fed with the following experimental diets for 4 weeks: (1) negative control (WR: diet with WR), (2) positive control (DSS_WR: DSS and diet with WR), (3) DSS_BR: DSS and diet with BR, and (4) DSS_R-BR: DSS and diet with R-BR...
November 17, 2017: Food & Function
https://www.readbyqxmd.com/read/29141970/natural-forms-of-vitamin-e-as-effective-agents-for-cancer-prevention-and-therapy
#4
REVIEW
Qing Jiang
Initial research on vitamin E and cancer has focused on α-tocopherol (αT), but recent clinical studies on cancer-preventive effects of αT supplementation have shown disappointing results, which has led to doubts about the role of vitamin E, including different vitamin E forms, in cancer prevention. However, accumulating mechanistic and preclinical animal studies show that other forms of vitamin E, such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE), and δ-tocotrienol (δTE), have far superior cancer-preventive activities than does αT...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29124932/effects-of-environmental-stresses-and-in-vitro-digestion-on-the-release-of-tocotrienols-encapsulated-within-chitosan-alginate-microcapsules
#5
Phui Yee Tan, Tai Boon Tan, Hon Weng Chang, Beng Ti Tey, Eng-Seng Chan, Oi-Ming Lai, Badlishah Sham Baharin, Imededdine Nehdi, Chin Ping Tan
Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1-9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic condition. The TM were also unstable against the effect of ionic strength, with a high release (70...
November 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29105089/wrinkled1-and-acyl-coa-diacylglycerol-acyltransferase1-regulate-tocochromanol-metabolism-in-arabidopsis
#6
Sébastien Pellaud, Alexandre Bory, Valentin Chabert, Joëlle Romanens, Laurie Chaisse-Leal, Anh Vu Doan, Lucas Frey, Andrea Gust, Katharina M Fromm, Laurent Mène-Saffrané
Photosynthetic organisms such as plants, algae and some cyanobacteria synthesize tocochromanols, a group of compounds that encompasses tocopherols and tocotrienols and that exhibits vitamin E activity in animals. While most vitamin E biosynthetic genes have been identified in plant genomes, regulatory genes controlling tocopherol accumulation are currently unknown. We isolated by forward genetics Arabidopsis enhanced vitamin E (eve) mutants that overaccumulate the classic tocopherols and plastochromanol-8, and a tocochromanol unknown in this species...
November 3, 2017: New Phytologist
https://www.readbyqxmd.com/read/29099067/the-content-of-tocols-in-south-african-wheat-impact-on-nutritional-benefits
#7
Maryke Labuschagne, Nomcebo Mkhatywa, Eva Johansson, Barend Wentzel, Angeline van Biljon
Wheat is a major component within human consumption, and due to the large intake of wheat, it has an impact on human nutritional health. This study aimed at an increased understanding of how the content and composition of tocols may be governed for increased nutritional benefit of wheat consumption. Therefore, ten South African wheat cultivars from three locations were fractionated into white and whole flour, the content and concentration of tocols were evaluated by high performance liquid chromatography (HPLC), and vitamin E activity was determined...
November 2, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29050412/adaptive-response-to-exercise-of-fast-growing-and-slow-growing-chicken-strains-blood-oxidative-status-and-non-enzymatic-antioxidant-defense
#8
S Mattioli, A Dal Bosco, S Ruggeri, M Martino, L Moscati, C Pesca, C Castellini
The adaptation of chickens to free-range rearing systems mainly involves the locomotory behavior, which is very different in fast-growing (FG) and slow-growing (SG) strains. This study aimed to compare the effect of moderate locomotory activity (induced and prolonged) on the blood oxidative status in a slow-growing chicken strain with that in a fast-growing one. Thirty FG (Ross 308) birds and 30 SG (Hubbard) birds were divided into 2 groups for each strain and subjected to different treatments: no exercise (the control group [C]) and 1 h of walking at 4 km/h (the exercise group [E])...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28978868/advances-in-genetic-improvement-for-tocotrienol-production-a-review
#9
Sulaiman Rufai Babura, Siti Nor Akmar Abdullah, Huzwah Khaza Ai
Tocotrienols are forms of vitamin E that are present in several important food crops. Compared to tocopherols, less research has been conducted on these compounds because of their low bioavailability and distribution in plant tissues. Both tocotrienols and tocopherols are known for their antioxidant and anticancer activities, which are beneficial for both humans and animals. Moreover, tocotrienols possess certain properties which are not found in tocopherols, such as neuroprotective and cholesterol-lowering activities...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28972460/tumor-regression-and-modulation-of-gene-expression-via-tumor-targeted-tocotrienol-niosomes
#10
Doryn Meam-Yee Tan, Ju-Yen Fu, Fu-Shun Wong, Hui-Meng Er, Yu-Sui Chen, Kalanithi Nesaretnam
AIM: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer. MATERIALS & METHODS: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy. RESULTS: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1...
October 2017: Nanomedicine
https://www.readbyqxmd.com/read/28970338/novel-loci-underlie-natural-variation-in-vitamin-e-levels-in-maize-grain
#11
Christine H Diepenbrock, Catherine B Kandianis, Alexander E Lipka, Maria Magallanes-Lundback, Brieanne Vaillancourt, Elsa Góngora-Castillo, Jason G Wallace, Jason Cepela, Alex Mesberg, Peter Bradbury, Daniel C Ilut, Maria Mateos-Hernandez, John Hamilton, Brenda F Owens, Tyler Tiede, Edward S Buckler, Torbert Rocheford, C Robin Buell, Michael A Gore, Dean DellaPenna
Tocopherols, tocotrienols and plastochromanols (collectively termed tocochromanols) are lipid-soluble antioxidants synthesized by all plants. Their dietary intake, primarily from seed oils, provides vitamin E and other health benefits. Tocochromanol biosynthesis has been dissected in the dicot Arabidopsis thaliana, which has green, photosynthetic seeds, but our understanding of tocochromanol accumulation in major crops, whose seeds are non-photosynthetic, remains limited. To understand the genetic control of tocochromanols in grain, we conducted a joint linkage and genome-wide association study in the 5,000-line U...
October 2, 2017: Plant Cell
https://www.readbyqxmd.com/read/28958562/effects-of-storage-and-yogurt-matrix-on-the-stability-of-tocotrienols-encapsulated-in-chitosan-alginate-microcapsules
#12
Phui Yee Tan, Tai Boon Tan, Hon Weng Chang, Beng Ti Tey, Eng Seng Chan, Oi Ming Lai, Badlishah Sham Baharin, Imededdine Arbi Nehdi, Chin Ping Tan
Tocotrienol microcapsules (TM) were formed by firstly preparing Pickering emulsion containing tocotrienols, which was then gelled into microcapsules using alginate and chitosan. In this study, we examined the stability of TM during storage and when applied into a model food system, i.e. yogurt. During storage at 40°C, TM displayed remarkably lower tocotrienols loss (50.8%) as compared to non-encapsulated tocotrienols in bulk oil (87.5%). When the tocotrienols were incorporated into yogurt, the TM and bulk oil forms showed a loss of 23...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28952200/tocotrienol-rich-fraction-attenuates-uv-induced-inflammaging-a-bench-to-bedside-study
#13
Wei Ney Yap
BACKGROUND: UV radiation from the sun is the most common environmental stressor to damage the skin. It is now well established that photodamaged skin manifests signs of mild but chronic inflammation, termed as "inflammaging." Thus, there is an urgent need for anti-inflammatory regimes that can limit the damage caused by inflammation. OBJECTIVES: This study aimed to evaluate the possible palliative effects of a new topical nanoemulsion formulation containing tocotrienol-rich fraction (TRF) on UV-induced inflammation (erythema) of human skin...
September 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28946335/tocotrienols-and-tocopherols-in-colored-grain-wheat-tritordeum-and-barley
#14
Jaromír Lachman, Alena Hejtmánková, Matyáš Orsák, Marek Popov, Petr Martinek
Colored-grain spring and winter wheat, spring tritordeum and barley (blue aleurone, purple pericarp, and yellow endosperm) from the harvests 2014 and 2015 were evaluated for tocol contents by HPLC-FD. Higher content of total tocols was found in spring wheat varieties compared with winter varieties. Four tocols (β-tocotrienol, α-tocotrienol, β-tocopherol, and α-tocopherol) were identified in wheat and tritordeum varieties. Dominant tocols in purple- and blue-grained wheat and yellow-grained tritordeum were α-tocopherol and β-tocotrienol, whereas spring barley varieties differed from wheat and tritordeum by high α-tocotrienol content...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28943456/permethrin-pesticide-induces-nurr1-up-regulation-in-dopaminergic-cell-line-is-the-pro-oxidant-effect-involved-in-toxicant-neuronal-damage
#15
Laura Bordoni, Donatella Fedeli, Cinzia Nasuti, Melania Capitani, Dennis Fiorini, Rosita Gabbianelli
The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) used to solubilize the toxicant...
September 22, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28932080/comparison-between-tocotrienol-and-omeprazole-on-gastric-growth-factors-in-stress-exposed-rats
#16
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Kien Hui Chua, Yusof Kamisah
AIM: To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS: Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehicle) and the two treatment groups were given omeprazole (20 mg/kg) or tocotrienol (60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28917729/hplc-apci-ms-ms-method-development-and-validation-for-determination-of-tocotrienols-in-human-breast-adipose-tissue
#17
Ewa Bartosińska, Julia Jacyna, Agnieszka Borsuk-De Moor, Michał Kaliszan, Wiesław Janusz Kruszewski, Zbigniew Jankowski, Danuta Siluk
For the last decade, significant attention has been paid to the potential role of tocotrienols in prevention and therapy of breast cancer. Therefore, the aim of this study was to develop and validate analytical method for quantitative determination of tocotrienols (α-, β-, γ- and δ-tocotrienol) in human breast adipose tissue with the use of high performance liquid chromatography coupled with APCI-MS/MS detection. Separation of target compounds was achieved within 10min with the use of naphthylethyl Cosmosil 2...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28912593/effect-of-palm-based-tocotrienols-and-tocopherol-mixture-supplementation-on-platelet-aggregation-in-subjects-with-metabolic-syndrome-a-randomised-controlled-trial
#18
Yee-Lin Gan, Ju-Yen Fu, Oi-Ming Lai, Boon-How Chew, Kah-Hay Yuen, Kim-Tiu Teng, Kalanithi Nesaretnam, Kanga Rani Selvaduray, Puvaneswari Meganathan
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899235/oxidative-status-and-reduced-glutathione-levels-in-premature-coronary-artery-disease-and-coronary-artery-disease
#19
Qurratu Aini Musthafa, Muhd Faizan Abdul Shukor, Noor Akmal Shareela Ismail, Azmee Mohd Ghazi, Rosli Mohd Ali, Ika Faizura M Nor, Mohd Zamrin Dimon, Wan Zurinah Wan Ngah
Identifying patients at risk of developing premature coronary artery disease (PCAD) which occurs at age below 45 years old and constitutes approximately 7-10% of coronary artery disease (CAD) worldwide remains a problem. Oxidative stress has been proposed as a crucial step in the early development of PCAD. This study was conducted to determine the oxidative status of PCAD in comparison to CAD patients. PCAD (<45 years old) and CAD (>60 years old) patients were recruited with age-matched controls (n = 30, each group)...
October 2017: Free Radical Research
https://www.readbyqxmd.com/read/28891093/tocotrienols-for-bone-health-a-translational-approach
#20
REVIEW
Chwan-Li Shen, Annika Klein, Kok-Yong Chin, Huanbiao Mo, Peihsuan Tsai, Rong-Sen Yang, Ming-Chien Chyu, Soelaiman Ima-Nirwana
Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality...
August 2017: Annals of the New York Academy of Sciences
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