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tocotrienols

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https://www.readbyqxmd.com/read/28917729/hplc-apci-ms-ms-method-development-and-validation-for-determination-of-tocotrienols-in-human-breast-adipose-tissue
#1
Ewa Bartosińska, Julia Jacyna, Agnieszka Borsuk-De Moor, Michał Kaliszan, Wiesław Janusz Kruszewski, Zbigniew Jankowski, Danuta Siluk
For the last decade, significant attention has been paid to the potential role of tocotrienols in prevention and therapy of breast cancer. Therefore, the aim of this study was to develop and validate analytical method for quantitative determination of tocotrienols (α-, β-, γ- and δ-tocotrienol) in human breast adipose tissue with the use of high performance liquid chromatography coupled with APCI-MS/MS detection. Separation of target compounds was achieved within 10min with the use of naphthylethyl Cosmosil 2...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28912593/effect-of-palm-based-tocotrienols-and-tocopherol-mixture-supplementation-on-platelet-aggregation-in-subjects-with-metabolic-syndrome-a-randomised-controlled-trial
#2
Yee-Lin Gan, Ju-Yen Fu, Oi-Ming Lai, Boon-How Chew, Kah-Hay Yuen, Kim-Tiu Teng, Kalanithi Nesaretnam, Kanga Rani Selvaduray, Puvaneswari Meganathan
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899235/oxidative-status-and-reduced-glutathione-levels-in-premature-coronary-artery-disease-and-coronary-artery-disease
#3
Qurratu Aini Musthafa, Noor Akmal Shareela Ismail, Muhd Faizan Abdul Shukor, Azmee Mohd Ghani, Rosli Mohd Ali, Ika Faizura M Nor, Mohd Zamrin Dimon, Ngah Wan, Zurinah Wan
Identifying patients at risk of developing premature coronary artery disease (PCAD) which occurs at age below 45 years old and constitutes approximately 7-10% of coronary artery disease (CAD) worldwide remains a problem. Oxidative stress has been proposed as a crucial step in the early development of PCAD. This study was conducted to determine the oxidative status of PCAD in comparison to CAD patients. PCAD (<45 years old) and CAD (>60 years old) patients were recruited with age-matched controls (n=30, each group)...
September 12, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28891093/tocotrienols-for-bone-health-a-translational-approach
#4
REVIEW
Chwan-Li Shen, Annika Klein, Kok-Yong Chin, Huanbiao Mo, Peihsuan Tsai, Rong-Sen Yang, Ming-Chien Chyu, Soelaiman Ima-Nirwana
Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Animal studies show that ingestion of vitamin E, especially tocotrienols, may benefit bone health in terms of maintaining higher bone mineral density and improving bone microstructure and quality...
August 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28883825/seed-carotenoid-and-tocochromanol-composition-of-wild-fabaceae-species-is-shaped-by-phylogeny-and-ecological-factors
#5
Beatriz Fernández-Marín, Fátima Míguez, Leire Méndez-Fernández, Agustí Agut, José M Becerril, José I García-Plazaola, Ilse Kranner, Louise Colville
Carotenoids distribution and function in seeds have been very scarcely studied, notwithstanding their pivotal roles in plants that include photosynthesis and phytohormone synthesis, pigmentation, membrane stabilization and antioxidant activity. Their relationship with tocochromanols, whose critical role in maintaining seed viability has already been evidenced, and with chlorophylls, whose retention in mature seed is thought to have negative effects on storability, remain also unexplored. Here, we aimed at elucidating seed carotenoids relationship with tocochromanols and chlorophylls with regard to phylogenetic and ecological traits and at understanding their changes during germination...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28880217/the-ameliorative-effects-of-a-tocotrienol-rich-fraction-on-the-age-rage-axis-and-hypertension-in-high-fat-diet-fed-rats-with-metabolic-syndrome
#6
Hong Sheng Cheng, So Ha Ton, Joash Ban Lee Tan, Khalid Abdul Kadir
The clinical value of tocotrienols is increasingly appreciated because of the unique therapeutic effects that are not shared by tocopherols. However, their effect on metabolic syndrome is not well-established. This study aimed to investigate the effects of a tocotrienol-rich fraction (TRF) from palm oil in high-fat-diet-treated rats. Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks. Physical, metabolic, and histological changes were compared to those on control and high-fat diets respectively...
September 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28865183/comparision-of-chemical-profile-and-antioxidant-capacity-of-seeds-and-oils-from-salvia-sclarea-and-salvia-officinalis
#7
Jelena Živković, Mihailo Ristić, Josephine Kschonsek, Anna Westphal, Milica Mihailović, Vladimir Filipović, Volker Böhm
Composition of tocopherols, tocotrienols, carotenoids, fatty acids as well as hydrophilic and lipophilic antioxidant activities were determined in seeds of two Salvia species and oils obtained from them. Both seeds contained a large amount of oil (around 20%) rich in polyunsaturated fatty acids. While S. officinalis seed oil can be classified as oleic-linoleic oil, the predominant fatty acid in S. sclarea was α-linolenic acid (around 54%). Among tocols, the main isomers in both seeds and oils were γ-tocopherol, followed by α-tocopherol...
September 2, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28803863/epidermal-e-cadherin-dependent-%C3%AE-catenin-pathway-is-phytochemical-inducible-and-accelerates-anagen-hair-cycling
#8
Noha S Ahmed, Subhadip Ghatak, Mohamed S El Masry, Surya C Gnyawali, Sashwati Roy, Mohamed Amer, Helen Everts, Chandan K Sen, Savita Khanna
Unlike the epidermis, which regenerates continually, hair follicles anchored in the subcutis periodically regenerate by spontaneous repetitive cycles of growth (anagen), degeneration (catagen), and rest (telogen). The loss of hair follicles in response to injuries or pathologies such as alopecia endangers certain inherent functions of the skin. Thus, it is of interest to understand mechanisms underlying follicular regeneration in adults. In this work, a phytochemical rich in the natural vitamin E tocotrienol (TRF) served as a productive tool to unveil a novel epidermal pathway of hair follicular regeneration...
July 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28797930/%C3%AE-tocotrienol-induced-disruption-of-lipid-rafts-in-human-breast-cancer-cells-is-associated-with-a-reduction-in-exosome-heregulin-content
#9
Osama A Alawin, Rayan A Ahmed, Venkateshwararao Dronamraju, Karen P Briski, Paul W Sylvester
Overexpression of heregulin, a potent ligand that activates HER3 and HER4 receptors, plays a significant role in the development of chemotherapy resistance in breast cancer patients. Exosomes released from cancer cells are small vesicles originating from the outward budding of lipid rafts that carry various mitogenic proteins that then act locally in an autocrine/paracrine manner to stimulate cancer cell growth. Since the anticancer activity of γ-tocotrienol has been shown to be mediated in part through the disruption of lipid rafts, studies were conducted to determine the effect of γ-tocotrienol on exosomes mitogenic biopotency...
July 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28789906/tocotrienols-the-unsaturated-sidekick-shifting-new-paradigms-in-vitamin-e-therapeutics
#10
REVIEW
Madhu M Kanchi, Muthu K Shanmugam, Grishma Rane, Gautam Sethi, Alan P Kumar
Vitamin E family members: tocotrienols and tocopherols are widely known for their health benefits. Decades of research on tocotrienols have shown they have diverse biological activities such as antioxidant, anti-inflammatory, anticancer, neuroprotective and skin protection benefits, as well as improved cognition, bone health, longevity and reduction of cholesterol levels in plasma. Tocotrienols also modulate several intracellular molecular targets and, most importantly, have been shown to improve lipid profiles, reduce total cholesterol and reduce the volume of white matter lesions in human clinical trials...
August 5, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28777347/%C3%AE-tocotrienol-inhibits-proliferation-and-induces-apoptosis-via-the-mitochondrial-pathway-in-human-cervical-cancer-hela-cells
#11
Weili Xu, Yaqing Mi, Pan He, Shenghua He, Lingling Niu
γ-Tocotrienol, a kind of isoprenoid phytochemical, has antitumor activity. However, there is limited evidence that it has an effect on cervical cancer. In this study, the capacity to inhibit proliferation and induce apoptosis in human cervical cancer HeLa cells and the mechanism underlying these effects were examined. The results indicated that a γ-tocotrienol concentration over 30 μM inhibited the growth of HeLa cells with a 50% inhibitory concentration (IC50) of 46.90 ± 3.50 μM at 24 h, and significantly down-regulated the expression of proliferative cell nuclear antigen (PCNA) and Ki-67...
August 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28759786/high-purity-tocotrienols-attenuate-atherosclerotic-lesion-formation-in-apoe-ko-mice
#12
Akira Shibata, Teiko Kobayashi, Akira Asai, Takahiro Eitsuka, Shinichi Oikawa, Teruo Miyazawa, Kiyotaka Nakagawa
Previous studies have demonstrated that tocotrienol (T3) has antiatherogenic effects. However, the T3 preparations used in those studies contained considerable amounts of tocopherol (Toc), which might affect the biological activity of T3. There is little information on the effect of highly purified T3 on atherosclerosis formation. This study investigated the effect of high-purity T3 on atherosclerotic lesion formation and the underlying mechanisms. Male apolipoprotein E knockout (apoE-KO) mice were fed a cholesterol-containing diet either alone or supplemented with T3 concentrate (Toc-free T3) or with α-Toc for 12 weeks...
June 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28756671/tocopherols-tocomonoenols-and-tocotrienols-in-oils-of-costa-rican-palm-fruits-a-comparison-between-six-varieties-and-chemical-versus-mechanical-extraction
#13
COMPARATIVE STUDY
Andrea Irías-Mata, Wolfgang Stuetz, Nadine Sus, Simon Hammann, Katrin Gralla, Aracelly Cordero-Solano, Walter Vetter, Jan Frank
Palm oil is one of the richest sources of tocotrienols and may contain other non-tocopherol vitamin E congeners. The vitamin E profiles of fully ripened fruit mesocarp of three Elaeis guineensis, two Elaeis oleifera, and one hybrid O × G palm fruit genotypes from Costa Rica were analyzed by high-performance liquid chromatography with fluorescence detection and gas chromatography-mass spectrometry after mechanical extraction by a screw press and chemical extraction with hexane. γ-Tocotrienol, α-tocotrienol, and α-tocopherol were the most abundant tocochromanols, while other tocopherols (β-tocopherol, γ-tocopherol, and δ-tocopherol) and α-tocomonoenol were detected at minor concentrations...
August 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28725195/vitamin-e-as-a-potential-interventional-treatment-for-metabolic-syndrome-evidence-from-animal-and-human-studies
#14
REVIEW
Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana
A constellation of medical conditions inclusive of central obesity, hyperglycemia, hypertension, and dyslipidemia is known as metabolic syndrome (MetS). The safest option in curtailing the progression of MetS is through maintaining a healthy lifestyle, which by itself, is a long-term commitment entailing much determination. A combination of pharmacological and non-pharmacological approach, as well as lifestyle modification is a more holistic alternative in the management of MetS. Vitamin E has been revealed to possess anti-oxidative, anti-inflammatory, anti-obesity, anti-hyperglycemic, anti-hypertensive and anti-hypercholesterolemic properties...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28722810/impact-of-crude-oil-quality-on-the-refining-conditions-and-composition-of-nutraceuticals-in-refined-palm-oil
#15
Klicia A Sampaio, Jose Vila Ayala, Vera Van Hoed, Simone Monteiro, Roberta Ceriani, Roland Verhé, Antonio J A Meirelles
Palm oil is the major vegetable oil used worldwide due to its unique properties. The effect of crude palm oil acidity on the final free fatty acids (FFA) content, neutral oil loss (NOL), and nutraceutical compounds, such as carotenes, total tocols (tocopherols and tocotrienols), squalene, and phytosterols was investigated. A central composite design was employed to study the influence of the refining conditions: temperature (200 to 260 °C), steam percentage (0.5% to 3.5%), and initial FFA content (2.2% to 6...
July 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28714405/emerging-targets-to-relieve-fat-stress-induced-liver-diseases-udca-tocotrienol-%C3%AF-3-pufas-and-igy-targeted-npc1l1-cholesterol-transporter
#16
Ji-Young Cha, Jong-Min Park, Ho-Jae Lee, Jin-Sik Bae, Young-Min Han, Byung-Chul Oh, Kwang Hyun Ko, Ki-Baik Hahm
Fat stress-induced liver disease is a hepatic manifestation of metabolic syndrome initiated by excess fat accumulation and encompasses a wide spectrum of diseases from non-alcoholic fatty liver disease to non-alcoholic steatohepatitis, a precursor lesion progressing to more aggressive liver cirrhosis and hepatocellular carcinoma. Although the incidence of these fat stress-induced liver diseases is rapidly increasing worldwide in parallel with the growing epidemics of obesity and metabolic diseases, its exact pathogenesis is not well defined...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28707601/potential-role-of-natural-compounds-as-anti-angiogenic-agents-in-cancer
#17
Muthu K Shanmugam, Sudha Warrier, Alan Prem Kumar, Gautam Sethi, Frank Arfuso
BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28684161/vitamin-e-isoform-%C3%AE-tocotrienol-protects-against-emphysema-in-cigarette-smoke-induced-copd
#18
Hong Yong Peh, W S Daniel Tan, Tze Khee Chan, Chen Wei Pow, Paul S Foster, W S Fred Wong
Inflammation and oxidative stress contribute to emphysema in COPD. Although corticosteroids are the standard of care for COPD, they do not reduce oxidative stress, and a subset of patients is steroid-resistant. Vitamin E isoform γ-tocotrienol possesses both anti-inflammatory and anti-oxidative properties that may protect against emphysema. We aimed to establish the therapeutic potential of γ-tocotrienol in cigarette smoke-induced COPD models in comparison with prednisolone. BALB/c mice were exposed to cigarette smoke for 2 weeks or 2 months...
July 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28672950/tocotrienol-alleviates-inflammation-and-oxidative-stress-in-a-rat-model-of-spinal-cord-injury-via-suppression-of-transforming-growth-factor-%C3%AE
#19
Chuanhui Xun, Mardan Mamat, Hailong Guo, Pulat Mamati, Jun Sheng, Jian Zhang, Tao Xu, Weidong Liang, Rui Cao, Weibin Sheng
In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the effect of tocotrienols on spinal cord injury (SCI) by evaluating oxidative stress, inflammation and inducible nitric oxide synthase (iNOS) in rats. A rat model of SCI was induced by operation. SCI rats were treated with 120 mg/kg/day tocotrienol once a day for eight consecutive weeks...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28657605/pharmacological-modulation-of-radiation-damage-does-it-exist-a-chance-for-other-substances-than-hematopoietic-growth-factors-and-cytokines
#20
REVIEW
Michal Hofer, Zuzana Hoferová, Martin Falk
In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage...
June 28, 2017: International Journal of Molecular Sciences
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