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https://www.readbyqxmd.com/read/29671676/effects-of-gabapentin-pregabalin-and-gastroretentive-gabapentin-on-simulated-driving-daytime-sedation-and-cognition
#1
Peter Schmidt, Srinivas Rao
AIM: Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). METHODS: Driving attentiveness, sleepiness and cognition were evaluated prior to subjects receiving study doses. Blood samples were collected during each treatment. RESULTS: Subjects receiving gastroretentive gabapentin showed less change in variation in lateral lane position (p = 0...
April 19, 2018: Pain Management
https://www.readbyqxmd.com/read/29668559/gabapentin-improves-symptoms-of-functional-dyspepsia-in-a-retrospective-open-label-cohort-study
#2
Kyle Staller, Andrea H Thurler, Justin S Reynolds, Laurie R Dimisko, Ryan McGovern, Kristina F Skarbinski, Braden Kuo
GOALS: We sought to determine the efficacy of gabapentin in the treatment of functional dyspepsia among an observational cohort of patients. BACKGROUND: Gabapentin has an established role in the treatment of neuropathic pain, with evidence supporting a benefit in visceral hypersensitivity. There is currently no data on the use of gabapentin for the treatment of functional dyspepsia. STUDY: Consecutive patients presenting to a tertiary motility clinic for the evaluation of functional dyspepsia without concurrent gastric emptying delay completed a baseline Patient Assessment of Gastrointestinal Disorders-Symptom Severity Index (PAGI-SYM) before evaluation and were started on gabapentin for functional dyspepsia by their providers...
April 17, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29661153/improved-analgesia-and-reduced-post-operative-nausea-and-vomiting-after-implementation-of-an-enhanced-recovery-after-surgery-eras-pathway-for-total-mastectomy
#3
Catherine Chiu, Pedram Aleshi, Laura J Esserman, Christina Inglis-Arkell, Edward Yap, Elizabeth L Whitlock, Monica W Harbell
BACKGROUND: Enhanced Recovery After Surgery (ERAS) pathways have been shown in multiple surgical disciplines to improve outcomes, including reduced opioid consumption, length of stay, and post-operative nausea and vomiting (PONV). However, very few studies describe the application of ERAS to breast surgery and even fewer describe ERAS for outpatient surgery. We describe the implementation and efficacy of an Enhanced Recovery After Surgery (ERAS) pathway for total skin-sparing mastectomy with immediate reconstruction in an outpatient setting...
April 16, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29658795/an-update-and-systematic-review-on-drug-therapies-for-the-treatment-of-refractory-chronic-cough
#4
Nicole M Ryan, Anne E Vertigan, Surinder S Birring
Chronic Cough (CC) is common and often associated with significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is refractory despite extensive investigation and treatment trials. It is likely that the key abnormality in refractory CC is dysfunctional, hypersensitive sensory nerves, similar to conditions such as laryngeal hypersensitivity and neuropathic pain. Areas covered: The aim of this systematic review is to assess drug therapies for refractory CC. The authors review the current management of CC and provide discussion of the similarities between neuropathic pain and refractory CC...
April 16, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29651850/exploring-the-potential-of-a-global-emerging-contaminant-early-warning-network-through-the-use-of-retrospective-suspect-screening-with-high-resolution-mass-spectrometry
#5
Nikiforos A Alygizakis, Saer Samanipour, Juliane Hollender, María Ibáñez, Sarit Kaserzon, Varvara Kokkali, Jan A van Leerdam, Jochen F Mueller, Martijn Pijnappels, Malcolm J Reid, Emma L Schymanski, Jaroslav Slobodnik, Nikolaos S Thomaidis, Kevin V Thomas
A key challenge in the environmental and exposure sciences is to establish experimental evidence of the role of chemical exposure in human and environmental systems. High resolution and accurate tandem mass spectrometry (HRMS) is increasingly being used for the analysis of environmental samples. One lauded benefit of HRMS is the possibility to retrospectively process data for (previously omitted) compounds that has led to the archiving of HRMS data. Archived HRMS data affords the possibility of exploiting historical data to rapidly and effectively establish the temporal and spatial occurrence of newly identified contaminants through retrospective suspect screening...
April 13, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29650881/-combination-therapy-of-oxycodone-and-tapentadol-was-effective-for-intractable-pain-caused-by-breast-cancer-bone-metastasis-a-case-report
#6
Tetsuya Matsuura, Akihiko Kusakabe, Takaomi Kessoku, Yasushi Honda, Asuka Yoshimi, Ayumu Goto, Haruhisa Yoshida, Akiko Sukegawa, Atsushi Nakajima, Yasushi Ichikawa
A 52-year-old woman had been prescribed oral medication of acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and oxycodone for intractable pain associated with thoracic metastasis of breast cancer. However, the pain control was poor. Although pregabalin and gabapentin were used as supplementary analgesics, they could not be continued because of their side effects. Based on the noradrenalin reincorporation-inhibiting action of tapentadol, a combination therapy of tapentadol and oxycodone was introduced and satisfactory pain control was achieved...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650808/correction-adverse-pregnancy-outcomes-in-women-exposed-to-gabapentin-and-pregabalin-data-from-a-population-based-study
#7
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29648417/the-influence-of-gabapentin-on-postoperative-outcome-in-obese-patients
#8
Anna Rupniewska-Ladyko
No abstract text is available yet for this article.
April 12, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29645361/perioperative-analgesia-for-patients-undergoing-endoscopic-sinus-surgery-an-evidence-based-review
#9
REVIEW
Peter F Svider, Brandon Nguyen, Brian Yuhan, Giancarlo Zuliani, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Misuse and diversion of prescription opioids have been critical in facilitating the opioid epidemic. Our objective was to perform a systematic evidence-based review delineating perioperative regimens (including opioid alternatives) evaluated for endoscopic sinus surgery. METHODS: PubMed/MEDLINE, Cochrane Library, and EmBase databases were evaluated for studies detailing analgesics employed after endoscopic sinus surgery. Studies were assessed for level of evidence...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29643896/potential-drug-drug-interactions-among-patients-prescriptions-collected-from-medicine-out-patient-setting
#10
Riffat Farooqui, Talea Hoor, Nasim Karim, Mehtab Muneer
Objective: To identify and evaluate the frequency, severity, mechanism and common pairs of drug-drug interactions (DDIs) in prescriptions by consultants in medicine outpatient department. Methods: This cross sectional descriptive study was done by Pharmacology department of Bahria University Medical & Dental College (BUMDC) in medicine outpatient department (OPD) of a private hospital in Karachi from December 2015 to January 2016. A total of 220 prescriptions written by consultants were collected...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643553/the-effect-of-pre-emptive-gabapentin-on-anaesthetic-and-analgesic-requirements-in-patients-undergoing-rhinoplasty-a-prospective-randomised-study
#11
Eman Ramadan Salama, Asmaa Fawzy Amer
Background and Aims: Hypotensive anaesthesia is necessary in rhinoplasty for better visualisation of surgical field and reduction of surgery time. Gabapentin is a new generation anticonvulsant with anti-hyperalgesic and anti-nociceptive properties. We aimed to investigate the effect of pre-operative administration of oral gabapentin (1200 mg) on anaesthetic requirements and post-operative analgesic consumption and its role in hypotensive anaesthesia for rhinoplasty. Methods: Seventy adult patients undergoing rhinoplasty, were randomly allocated to two groups...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29621123/development-and-validation-of-a-u-hplc-ms-ms-method-for-the-concurrent-measurement-of-gabapentin-lamotrigine-levetiracetam-monohydroxy-derivative-mhd-of-oxcarbazepine-and-zonisamide-concentrations-in-serum-in-a-clinical-setting
#12
Michael J Palte, Sankha S Basu, Jameson L Dahlin, Ralitsa Gencheva, Donald Mason, Petr Jarolim, Athena K Petrides
BACKGROUND: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is often necessary to prevent associated destructive toxicities. Tandem mass spectrometry (MS/MS) with stable-isotope-labeled (SIL) internal standards (ISs) is considered the gold standard for the measurement of AEDs. This study presents the development and validation of a clinical ultra-performance liquid chromatography (U-HPLC)-MS/MS method for the concurrent measurement of gabapentin, lamotrigine, levetiracetam, monohydroxy derivative (MHD) of oxcarbazepine, and zonisamide in human serum...
April 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29615898/antihyperalgesic-properties-of-honokiol-in-inflammatory-pain-models-by-targeting-of-nf-%C3%AE%C2%BAb-and-nrf2-signaling
#13
Sidra Khalid, Muhammad Z Ullah, Ashraf U Khan, Ruqayya Afridi, Hina Rasheed, Adnan Khan, Hussain Ali, Yeong S Kim, Salman Khan
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honokiol: a phenolic compound originally isolated from Magnolia officinalis , in acute and chronic inflammatory pain models. Doses of 0.1, 5, and 10 mg/kg honokiol were administered in carrageenan induced pain and the dose (honokiol 10 mg/kg i.p.) with most significant response among behavioral tests was selected for further experiments. The i.p. administration of honokiol inhibits mechanical hyperalgesia, mechanical allodynia, and thermal hyperalgesia, without causing any apparent toxicity...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29608639/transition-to-nonopioid-analgesia-does-not-impair-pain-control-after-major-aesthetic-plastic-surgery
#14
Thu-Hoai C Nguyen, Nicholas F Lombana, Dmitry Zavlin, Clayton L Moliver
Background: Multimodal analgesic protocols are increasingly favored over traditional opioid regimens due to decreased adverse side effects and reduced opioid consumption. Concomitant use of selective cyclooxygenase (COX)-2 inhibitor celecoxib and anticonvulsant gabapentin have been proposed to adequately control acute postoperative pain. Objectives: To determine efficacy of postoperative pain control using nonopioid pain regimen vs traditional opioids for all aesthetic plastic surgery procedures...
March 28, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29599901/management-of-restless-legs-syndrome-in-chronic-liver-disease-a-challenge-for-the-correct-diagnosis-and-therapy
#15
Rita Moretti, Paola Caruso, Marzia Tecchiolli, Silvia Gazzin, Claudio Tiribelli
AIM: To investigate the association between restless legs syndrome (RLS) and well-defined chronic liver disease, and the possible therapeutic options. METHODS: Two hundred and eleven patients with chronic liver disease, complaining of sleep disturbances, painful leg sensation and daily sleepiness, were included. Patients with persistent alcohol intake, recent worsening of clinical conditions, or hepatitis C virus were excluded. Diagnosis of RLS was suggested by the Johns Hopkins questionnaire and verified by fulfilling the diagnostic criteria by Allen...
March 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29599727/brain-gaba-and-glutamate-concentrations-following-chronic-gabapentin-administration-a-convenience-sample-studied-during-early-abstinence-from-alcohol
#16
Dieter J Meyerhoff, Donna E Murray, Timothy C Durazzo, David L Pennington
Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery. Using in vivo magnetic resonance spectroscopy, we tested the degree to which daily GBP alters regional brain GABA and Glu levels in short-term abstinent alcohol-dependent individuals. Regional metabolite levels were compared between 13 recently abstinent alcohol-dependent individuals who had received daily GBP for at least 1 week (GBP+) and 25 matched alcohol-dependent individuals who had not received GBP (GBP-)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29596101/intravenous-acetaminophen-does-not-reduce-inpatient-opioid-prescription-or-opioid-related-adverse-events-among-patients-undergoing-spine-surgery
#17
Eva E Mörwald, Jashvant Poeran, Nicole Zubizarreta, Crispiana Cozowicz, Madhu Mazumdar, Stavros G Memtsoudis
BACKGROUND: Having entered the US market relatively recently, the perioperative role of intravenous acetaminophen (ivAPAP) remains to be established for several surgeries. Using national data, we therefore assessed current utilization and whether it reduces inpatient opioid prescription and opioid-related side effects in a procedure with relatively high opioid utilization. METHODS: Patients undergoing a lumbar/lumbosacral spinal fusion (n = 117,269; 2011-2014) were retrospectively identified in a nationwide database and categorized by the amount and timing of ivAPAP administration (1 or >1 dose on postoperative day [POD] 0, 1, or 1+)...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#18
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29589069/effect-of-gabapentin-on-sleep-and-delta-and-theta-eeg-power-in-adult-rats-exposed-to-chronic-intermittent-ethanol-vapor-and-protracted-withdrawal-during-adolescence
#19
Cindy L Ehlers, Manuel Sanchez-Alavez, Derek Wills
RATIONALE: Adolescents and young adults with alcohol problems may also have sleep difficulties. However, whether these sleep problems are a result of a history of drinking or arise due to other comorbid disorders is difficult to disentangle in human studies. Additionally, the mechanisms underlying adolescent alcohol-induced sleep disturbances and potential targets for therapy also remain under-investigated. Recent clinical trials have demonstrated that the anticonvulsant and analgesic drug gabapentin may have therapeutic value in normalizing sleep quality in adult recovering alcoholics, yet its potential for the treatment of adolescent sleep disturbances has not been investigated...
March 27, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29580153/peripheral-nerve-injury-increases-contribution-of-l-type-calcium-channels-to-synaptic-transmission-in-spinal-lamina-ii-role-of-%C3%AE-2%C3%AE-1-subunits
#20
Sascha Ra Alles, Esperanza Garcia, Sridhar Balasubramanyan, Karen Jones, John R Tyson, Twinkle Joy, Terrance P Snutch, Peter A Smith
Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca2+ channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ-1 in Xenopus oocytes increases the opening properties of Cav 1.2 L-type channels and allows Ca2+ influx at physiological membrane potentials. We therefore posited that L-type channels play a role in neurotransmitter release in the superficial dorsal horn in the chronic constriction injury model of neuropathic pain...
January 2018: Molecular Pain
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