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JOURNAL ARTICLE
Giuseppe Luigi Banna, Mona Ali Hassan, Alessio Signori, Emilio Francesco Giunta, Akash Maniam, Shobana Anpalakhan, Shyamika Acharige, Aruni Ghose, Alfredo Addeo
IMPORTANCE: Randomized clinical trials (RCTs) with neoadjuvant immune checkpoint inhibitors (ICIs) plus chemotherapy (ICI-chemotherapy) for patients with early-stage non-small cell lung cancer (NSCLC) have reported consistent associations with event-free survival (EFS) and pathologic complete response (pCR) pending longer follow-up for overall survival data. OBJECTIVE: To assess the pooled benefit of ICI-chemotherapy in 2-year EFS and pCR among patients with NSCLC and examine the impact of clinical, pathologic, and treatment-related factors...
April 1, 2024: JAMA Network Open
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REVIEW
Miguel Martín, Atanasio Pandiella, Emilio Vargas-Castrillón, Elena Díaz-Rodríguez, Teresa Iglesias-Hernangómez, Concha Martínez Cano, Inés Fernández-Cuesta, Elena Winkow, Maria Francesca Perelló
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) consisting of a humanised, anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody covalently linked to a topoisomerase I inhibitor cytotoxic payload (DXd). The high drug-to-antibody ratio (8:1) ensures a high DXd concentration is delivered to target tumour cells, following internalisation of T-DXd and subsequent cleavage of its tetrapeptide-based linker. DXd's membrane-permeable nature enables it to cross cell membranes and potentially exert antitumour activity on surrounding tumour cells regardless of HER2 expression...
April 13, 2024: Critical Reviews in Oncology/hematology
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JOURNAL ARTICLE
Andrea Cabrera-Espinoza, Silvia Collavini, José G Sánchez, Ivet Kosta, Emilio Palomares, Juan Luis Delgado
Despite the high efficiencies currently achieved with perovskite solar cells (PSCs), the need to develop stable devices, particularly in humid conditions, still remains. This study presents the synthesis of a novel photo-cross-linkable fullerene-based hole transport material named FT12 . For the first time, the photo-cross-linking process is applied to PSCs, resulting in the preparation of photo-cross-linked FT12 (PCL FT12 ). Regular PSCs based on C60 -sandwich architectures were fabricated using FT12 and PCL FT12 as dopant-free hole transport layers (HTLs) and compared to the reference spiro-OMeTAD...
April 15, 2024: ACS Applied Materials & Interfaces
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REVIEW
Marianna Cocco, Carla Carnovale, Emilio Clementi, Maria Antonietta Barbieri, Vera Battini, Maurizio Sessa
INTRODUCTION: Drug-drug interactions (DDIs) are defined as the pharmacological effects produced by the concomitant administration of two or more drugs. To minimize false positive signals and ensure their validity when analyzing Spontaneous Reporting System (SRS) databases, it has been suggested to incorporate key pharmacological principles, such as temporal plausibility. AREAS COVERED: the scoping review of the literature was completed using MEDLINE from inception to March 2023...
April 15, 2024: Expert Review of Clinical Pharmacology
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JOURNAL ARTICLE
Maria Fernanda Di Gregorio, Carolina Der, Sofia Bravo-Torres, Mario Emilio Zernotti
Introduction Atresia of the external auditory canal affects 1 in every 10 thousand to 20 thousand live births, with a much higher prevalence in Latin America, at 5 to 21 out of every 10 thousand newborns. The treatment involves esthetic and functional aspects. Regarding the functional treatment, there are surgical and nonsurgical alternatives like spectacle frames and rigid and softband systems. Active transcutaneous bone conduction implants (BCIs) achieve good sound transmission and directly stimulate the bone...
April 2024: International Archives of Otorhinolaryngology
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REVIEW
Montse Guardiola, Pere Rehues, Núria Amigó, Francisco Arrieta, Manuel Botana, José A Gimeno-Orna, Josefa Girona, José Ignacio Martínez-Montoro, Emilio Ortega, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Juan Pedro-Botet, Josep Ribalta
The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between dyslipidaemia and atherosclerosis in T2DM is complex, and our contention is that a deeper understanding of lipoprotein composition and functionality, the vehicle that delivers cholesterol to the artery, will provide insight for improving our understanding of the hidden cardiovascular risk of diabetes...
April 13, 2024: European Journal of Clinical Investigation
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JOURNAL ARTICLE
Paula Soria-Chacartegui, Marcos Navares-Gómez, Francisca Molina-Jiménez, Emilio J Laserna-Mendieta, Laura Arias-González, Pedro Majano, Sergio Casabona, Alfredo J Lucendo, Francisco Abad-Santos, Cecilio Santander, Pablo Zubiaur
Proton pump inhibitors (PPIs) are the first-line drug for eosinophilic esophagitis (EoE), although it is estimated that there is a lack of histological remission in 50% of patients. This research aimed to identify pharmacogenetic biomarkers predictive of PPI effectiveness and to study their association with disease features. Peak eosinophil count (PEC) and the endoscopic reference score (EREFS) were determined before and after an eight-week PPI course in 28 EoE patients. The impact of the signal transducer and activator of transcription 6 ( STAT6 ), CYP2C19 , CYP3A4 , CYP3A5, and ABCB1 genetic variations on baseline PEC and EREFS, their reduction and histological response, and on EoE symptoms and comorbidities was analyzed...
March 26, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Lily Peikova, Maya Georgieva, Alexander Zlatkov
In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1 H -pyrrole-3-carboxylate ( 11b ) in hepatocytic media. The initial chromatographic procedure was based on the employment of the conventional octadecyl stationary phase method for estimation of the chemical stability. Subsequently, a novel and rapid chromatographic approach based on a phenyl-hexyl column was developed, aiming to separate the possible metabolites...
March 26, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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JOURNAL ARTICLE
Laura Pistoia, Antonella Meloni, Vincenzo Positano, Filomena Longo, Zelia Borsellino, Anna Spasiano, Riccardo Righi, Stefania Renne, Daniela Izzo, Ketty Savino, Sophie Mavrogeni, Emilio Quaia, Filippo Cademartiri, Alessia Pepe
Cardiac involvement in sickle beta thalassemia (Sβ-thal) patients has been poorly investigated. We aimed to evaluate cardiac function and myocardial iron overload by cardiovascular magnetic resonance (CMR) in patients with Sβ-thal. One-hundred and eleven Sβ-thal patients consecutively enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) network were studied and compared with 46 sickle cell anemia (SCA) patients and with 111 gender- and age- matched healthy volunteers. Cine images were acquired to quantify biventricular function...
March 26, 2024: Diagnostics
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JOURNAL ARTICLE
Gianniantonio Domina, Emilio Di Gristina, Giulio Barone
This study identified the most common poisonous and allergenic plants occurring in Sicilian gardens and parks. Based on a survey conducted at 100 sites, a list was drawn up that reports the main biological and toxicological characteristics and ornamental uses of these plants. A total of 137 taxa were recorded, of which 108 were poisonous and 32 were allergenic. The most represented families were the Solanaceae, Moraceae, Apocynaceae and Fabaceae. The most represented geographical contingents were the European and the Mediterranean...
April 5, 2024: Plants (Basel, Switzerland)
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JOURNAL ARTICLE
Filippo Gavi, Nazario Foschi, Daniele Fettucciari, Pierluigi Russo, Diana Giannarelli, Mauro Ragonese, Carlo Gandi, Giovanni Balocchi, Alessandra Francocci, Francesco Pio Bizzarri, Filippo Marino, Giovanni Battista Filomena, Giuseppe Palermo, Angelo Totaro, Marco Racioppi, Riccardo Bientinesi, Emilio Sacco
BACKGROUND: This study aimed to evaluate the surgical and oncological outcomes of robot-assisted radical cystectomy (RARC) versus open radical cystectomy (ORC) using trifecta and pentafecta parameters. METHODS: The clinical data of 41 patients who underwent RARC between 2018 and 2022 were prospectively collected and retrospectively compared to those of 330 patients undergoing ORC using 1:1 propensity score matching. Trifecta was defined as simultaneous negative surgical margins (SMs), a lymph node (LN) yield ≥ 16, and the absence of major complications (Clavien-Dindo grade III-V) within 90 days postoperatively...
March 25, 2024: Cancers
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JOURNAL ARTICLE
Silvia Mariel Ferrucci, Simona Tavecchio, Alessandro Ceresa, Luisa Angileri, Emilio Berti, Angelo Valerio Marzano, Massimiliano Buoli
Background : Atopic Dermatitis (AD) is a prevalent inflammatory skin disease whose course is often complicated by the presence of concomitant anxiety and depressive disorders. Dupilumab has been demonstrated to be largely effective in AD. The aims of the present study were to (1) to verify the effectiveness of 2-year dupilumab treatment on the depressive and anxiety symptoms of patients affected by AD and (2) to identify predictors of the persistence of psychiatric symptoms despite maintenance treatment with dupilumab...
March 29, 2024: Journal of Clinical Medicine
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REVIEW
Gabriele Centini, Giorgia Schettini, Emilio Pieri, Matteo Giorgi, Lucia Lazzeri, Francesco Giuseppe Martire, Virginia Mancini, Diego Raimondo, Renato Seracchioli, Nassir Habib, Francesco Fedele, Errico Zupi
BACKGROUND: Endometriosis affects more than 10% of reproductive-aged women, causing pelvic pain and infertility. Despite the benign nature of endometriosis, ovarian endometriomas carry a higher risk of developing endometrioid carcinomas (EnOCs) and clear cell ovarian carcinomas (CCCs). Atypical endometriosis, defined as cytological atypia resembling intraepithelial cancer, is considered the precursor of endometriosis-associated ovarian cancer (EAOC). This narrative review aims to provide an overview of EAOC, proposing a practical approach to clinical and therapeutic decision making...
March 27, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Aurelio Seidita, Alessandra Giuliano, Maurizio Soresi, Marta Chiavetta, Emilio Nardi, Giuseppe Mogavero, Giulio Giannone, Antonio Carroccio, Pasquale Mansueto
Some data suggest the existence of intestinal inflammation in patients with non-celiac wheat sensitivity (NCWS). We aimed to verify whether fecal calprotectin (FCP), a marker of intestinal inflammation, could be used to confirm this inflammatory status and to test its diagnostic performance in differentiating NCWS from irritable bowel syndrome/functional dyspepsia (IBS/FD). We conducted a multicenter study, comparing NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge, with IBS/FD subjects...
April 12, 2024: Internal and Emergency Medicine
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JOURNAL ARTICLE
David J Eldridge, Jingyi Ding, Josh Dorrough, Manuel Delgado-Baquerizo, Osvaldo Sala, Nicolas Gross, Yoann Le Bagousse-Pinguet, Max Mallen-Cooper, Hugo Saiz, Sergio Asensio, Victoria Ochoa, Beatriz Gozalo, Emilio Guirado, Miguel García-Gómez, Enrique Valencia, Jaime Martínez-Valderrama, César Plaza, Mehdi Abedi, Negar Ahmadian, Rodrigo J Ahumada, Julio M Alcántara, Fateh Amghar, Luísa Azevedo, Farah Ben Salem, Miguel Berdugo, Niels Blaum, Bazartseren Boldgiv, Matthew Bowker, Donaldo Bran, Chongfeng Bu, Rafaella Canessa, Andrea P Castillo-Monroy, Ignacio Castro, Patricio Castro-Quezada, Simone Cesarz, Roukaya Chibani, Abel Augusto Conceição, Anthony Darrouzet-Nardi, Yvonne C Davila, Balázs Deák, Paloma Díaz-Martínez, David A Donoso, Andrew David Dougill, Jorge Durán, Nico Eisenhauer, Hamid Ejtehadi, Carlos Ivan Espinosa, Alex Fajardo, Mohammad Farzam, Ana Foronda, Jorgelina Franzese, Lauchlan H Fraser, Juan Gaitán, Katja Geissler, Sofía Laura Gonzalez, Elizabeth Gusman-Montalvan, Rosa Mary Hernández, Norbert Hölzel, Frederic Mendes Hughes, Oswaldo Jadan, Anke Jentsch, Mengchen Ju, Kudzai F Kaseke, Melanie Köbel, Anika Lehmann, Pierre Liancourt, Anja Linstädter, Michelle A Louw, Quanhui Ma, Mancha Mabaso, Gillian Maggs-Kölling, Thulani P Makhalanyane, Oumarou Malam Issa, Eugene Marais, Mitchel McClaran, Betty Mendoza, Vincent Mokoka, Juan P Mora, Gerardo Moreno, Seth Munson, Alice Nunes, Gabriel Oliva, Gastón R Oñatibia, Brooke Osborne, Guadalupe Peter, Margerie Pierre, Yolanda Pueyo, R Emiliano Quiroga, Sasha Reed, Ana Rey, Pedro Rey, Víctor Manuel Reyes Gómez, Víctor Rolo, Matthias C Rillig, Peter C le Roux, Jan Christian Ruppert, Ayman Salah, Phokgedi Julius Sebei, Anarmaa Sharkhuu, Ilan Stavi, Colton Stephens, Alberto L Teixido, Andrew David Thomas, Katja Tielbörger, Silvia Torres Robles, Samantha Travers, Orsolya Valkó, Liesbeth van den Brink, Frederike Velbert, Andreas von Heßberg, Wanyoike Wamiti, Deli Wang, Lixin Wang, Glenda M Wardle, Laura Yahdjian, Eli Zaady, Yuanming Zhang, Xiaobing Zhou, Fernando T Maestre
Perennial plants create productive and biodiverse hotspots, known as fertile islands, beneath their canopies. These hotspots largely determine the structure and functioning of drylands worldwide. Despite their ubiquity, the factors controlling fertile islands under conditions of contrasting grazing by livestock, the most prevalent land use in drylands, remain virtually unknown. Here we evaluated the relative importance of grazing pressure and herbivore type, climate and plant functional traits on 24 soil physical and chemical attributes that represent proxies of key ecosystem services related to decomposition, soil fertility, and soil and water conservation...
April 12, 2024: Nature Plants
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JOURNAL ARTICLE
Hannah G Rosenblum, Julia W Gargano, Angela A Cleveland, Rebecca M Dahl, Ina U Park, Erin Whitney, Jessica L Castilho, Emmanuel Sackey, Linda M Niccolai, Monica Brackney, Emilio Debess, Sara Ehlers, Nancy M Bennett, RaeAnne Kurtz, Elizabeth R Unger, Lauri E Markowitz
Objectives: Although invasive cervical cancer (ICC) rates have declined since the advent of screening, the annual age-adjusted ICC rate in the United States remains 7.5 per 100,000 women. Failure of recommended screening and management often precedes ICC diagnoses. The study aimed to evaluate characteristics of women with incident ICC, including potential barriers to accessing preventive care. Materials and Methods: We abstracted medical records for patients with ICC identified during 2008-2020 in five U.S...
April 12, 2024: Journal of Women's Health
#37
JOURNAL ARTICLE
Miguel Morales, Mohammad Rezayat, Sandra García-González, Antonio Mateo, Emilio Jiménez-Piqué
The development of direct dimethyl ether (DME) solid oxide fuel cells (SOFCs) has several drawbacks, due to the low catalytic activity and carbon deposition of conventional Ni-zirconia-based anodes. In the present study, the insertion of 2.0 wt.% Ru-Ce0.7 Zr0.3 O2-δ (ruthenium-zirconium-doped ceria, Ru-CZO) as an anode catalyst layer (ACL) is proposed to be a promising solution. For this purpose, the CZO powder was prepared by the sol-gel synthesis method, and subsequently, nanoparticles of Ru (1.0-2...
March 28, 2024: Nanomaterials
#38
JOURNAL ARTICLE
Antonio Vita, Stefano Barlati, Matteo Porcellana, Elisa Sala, Jacopo Lisoni, Luisa Brogonzoli, Mauro Emilio Percudani, Rosaria Iardino
INTRODUCTION: The Patient Journey Project aimed to analyze the scenario among Italian Mental Health Services (MHS) to understand the clinical interventions that are properly implemented and the ones deserving further implementation to design an effective treatment plan for patients living with schizophrenia (PLWS). METHODS: The 60-items survey was co-designed with all the stakeholders (clinicians, expert patients and caregivers) involved in the Patient Journey and focused on three phases of schizophrenia course: early detection and management, acute phase management, long-term management/continuity of care...
2024: Frontiers in Psychiatry
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JOURNAL ARTICLE
Simran K Johal, Emilio Ferrer
Romantic relationships are defined by emotion dynamics, or how the emotions of one partner at a single timepoint can affect their own emotions and the emotions of their partner at the next timepoint. Previous research has shown that the level of these emotion dynamics plays a role in determining the state and quality of the relationship. However, this research has not examined whether the estimated emotion dynamics change over time, and how the change in these dynamics might relate to relationship outcomes, despite changes in dynamics being likely to occur...
2024: Frontiers in Human Neuroscience
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JOURNAL ARTICLE
Josep M Cambra, Maria A Gil, Cristina Cuello, Alejandro Gonzalez-Plaza, Heriberto Rodriguez-Martinez, Nikolai Klymiuk, Emilio A Martinez, Inmaculada Parrilla
INTRODUCTION: Pregnancy success relies on the establishment of a delicate immune balance that requires the early activation of a series of local and systemic immune mechanisms. The changes in the immunological profile that are normally occurring in the pregnant uterus does not take place in cyclic (non-pregnant) uterus, a fact that has been widely explored in pigs at the tissue local level. Such differences would be especially important in the context of embryo transfer (ET), where a growing body of literature indicates that immunological differences at the uterine level between donors and recipients may significantly impact embryonic mortality...
2024: Frontiers in Veterinary Science
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