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Andrey A Toropov, Alla P Toropova, Alessandra Roncaglioni, Emilio Benfenati
Quantitative structure-activity relationships (QSARs) for prediction of toxicological endpoints built up with the CORAL software are discussed. Prejudices related to these QSAR models are listed. Possible ways to improve the software are discussed.
2018: Methods in Molecular Biology
Anna Lombardo, Giuseppa Raitano, Domenico Gadaleta, Emilio Benfenati
Nontesting methods (NTM) proved to be a valuable resource for risk assessment of chemical substances. Indeed, they can be particularly useful when the information provided by different sources was integrated to increase the confidence in the final result. This integration can be sometimes difficult because different methods can lead to conflicting results, and because a clear guideline for integrating information from different sources was not available in the recent past. In this chapter, we present and discuss the recently published guideline from EFSA for integrating and weighting evidence for scientific assessment...
2018: Methods in Molecular Biology
Amandine Luquiens, Anis Ben Said, Haïm Sadik, Emilio Ferrer Sánchez Del Villar, Arthur Le Manach, Benjamin Ambrosino, Christophe Tzourio, Amine Benyamina, Henri-Jean Aubin
INTRODUCTION: The objective for this study was to combine drinking characteristics and two subjective measures, drinker identity and alcohol-related quality of life, i.e., negative impact of alcohol on quality of life, to determine relevant profiles for indicated prevention programs. In particular, we hypothesized that different profiles of students with high level of alcohol consumption exist when exploring subjectivity. METHODS: We performed an online survey among 16,930 students...
June 22, 2018: Quality of Life Research
Helen Maia Tavares de Andrade, Vívian Pedigone Cintra, Milena de Albuquerque, Camila Callegari Piccinin, Luciana Cardoso Bonadia, Rafael Esteves Duarte Couteiro, Daniel Sabino de Oliveira, Rinaldo Claudino, Marcos Vinicius Magno Gonçalves, Mario Emilio Teixeira Dourado, Leonardo Cruz de Souza, Antônio Lúcio Teixeira, Laura de Godoy Rousseff Prado, Vitor Tumas, Acary Souza Bulle Oliveira, Anamarli Nucci, Iscia Lopes-Cendes, Wilson Marques, Marcondes C França
Intermediate-length cytosine-adenine-guanine nucleotide repeat expansions in the ATXN2 gene (which encodes for the protein Ataxin-2) have been linked to increased risk for amyotrophic lateral sclerosis (ALS) in different populations. There is no such study in the Brazilian population, which has a mixed ethnic background. We have thus selected 459 patients with ALS (372 Sporadic ALS and 87 Familial ALS) and 468 control subjects from 6 Brazilian centers to investigate this point. We performed polymerase chain reaction to determine the length of the ATXN2 alleles...
May 8, 2018: Neurobiology of Aging
Federica Camin, Matteo Perini, Luana Bontempo, Marco Galeotti, Emilio Tibaldi, Edi Piasentier
Multielement isotope ratio was assessed in fat and defatted (protein) fillet of 130 rainbow trout, reared with feed incorporating a high or low fish content in 20 Italian farms, focusing on two northern Italian regions (Friuli Venezia Giulia and Trentino). The aim was to investigate the ability of isotopic analysis to trace the geographical origin of trout, also according to the type of feed. The carbon, nitrogen and sulphur isotope ratios of feed and fillet were highly positively correlated both within each matrix (feed or fillet) and between the two matrices and negatively correlated with the δ2 H and δ18 O of feed and the δ2 Hfat ...
November 30, 2018: Food Chemistry
Mercedes Marín, Adrián Ruiz, Cristina Iglesias, Lidia Quiroga, Emilia Cercenado, Pablo Martín-Rabadán, Emilio Bouza, Belén Rodríguez-Sánchez
OBJECTIVES: The identification of Nocardia isolates still represents a challenge for MALDI-TOF MS despite its acceptance for most bacterial and fungal isolates. In this study we evaluate the identification of Nocardia isolates using direct spotting and an updated database. METHODS: Overall, 82 Nocardia isolates belonging to 13 species were identified by DNA sequence analysis of the 16S rRNA and secA1 genes. Nine of these well-characterized isolates from 6 Nocardia species were used to create an in-house library...
June 19, 2018: Clinical Microbiology and Infection
Patrick Saliba, Ana Hornero, Guillermo Cuervo, Immaculada Grau, Emilio Jimenez, Damaris Berbel, Purificación Martos, Juan Manuel Verge, Cristian Tebe, Jose María Martínez-Sánchez, Evelyn Shaw, Laura Gavaldà, Jordi Carratalà, Miquel Pujol
BACKGROUND: Short-term peripheral venous catheters are a significant source of health-care acquired bloodstream infections and a preventable cause of death. AIM: To assess the effectiveness of interventions applied to reduce the incidence and mortality associated with short peripheral venous catheter-related bloodstream infections (PVCR-BSI). METHODS: The intervention included continuous PVCR-BSI surveillance, implementation of preventive measures related to catheter insertion and maintenance in accordance with evidence-based recommendations and the hospital's own data, front-line staff educational campaigns, and assessment of adherence to hospital guidelines by ward rounds...
June 18, 2018: Journal of Hospital Infection
Emilio Vilanova, Hirma Ramírez-Angulo, Armando Torres-Lezama, Gerardo Aymard, Luis Gámez, Cristabel Durán, Lionel Hernández, Rafael Herrera, Geertje van der Heijden, Oliver L Phillips, Gregory J Ettl
Using data from 50 long-term permanent plots from across Venezuelan forests in northern South America, we explored large-scale patterns of stem turnover, aboveground biomass (AGB) and woody productivity (AGWP), and the relationships between them and with potential climatic drivers. We used principal component analysis coupled with generalized least squares models to analyze the relationship between climate, forest structure and stem dynamics. Two major axes associated with orthogonal temperature and moisture gradients effectively described more than 90% of the environmental variability in the dataset...
2018: PloS One
Valentina Zamboni, Rebecca Jones, Alessandro Umbach, Alessandra Ammoni, Maria Passafaro, Emilio Hirsch, Giorgio R Merlo
Rho-class small GTPases are implicated in basic cellular processes at nearly all brain developmental steps, from neurogenesis and migration to axon guidance and synaptic plasticity. GTPases are key signal transducing enzymes that link extracellular cues to the neuronal responses required for the construction of neuronal networks, as well as for synaptic function and plasticity. Rho GTPases are highly regulated by a complex set of activating (GEFs) and inactivating (GAPs) partners, via protein:protein interactions (PPI)...
June 20, 2018: International Journal of Molecular Sciences
Herwig P Moll, Klemens Pranz, Monica Musteanu, Beatrice Grabner, Natascha Hruschka, Julian Mohrherr, Petra Aigner, Patricia Stiedl, Luka Brcic, Viktoria Laszlo, Daniel Schramek, Richard Moriggl, Robert Eferl, Judit Moldvay, Katalin Dezso, Pedro P Lopez-Casas, Dagmar Stoiber, Manuel Hidalgo, Josef Penninger, Maria Sibilia, Balázs Győrffy, Mariano Barbacid, Balázs Dome, Helmut Popper, Emilio Casanova
On the basis of clinical trials using first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), it became a doctrine that V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( K-RAS ) mutations drive resistance to EGFR inhibition in non-small cell lung cancer (NSCLC). Conversely, we provide evidence that EGFR signaling is engaged in K-RAS-driven lung tumorigenesis in humans and in mice. Specifically, genetic mouse models revealed that deletion of Egfr quenches mutant K-RAS activity and transiently reduces tumor growth...
June 20, 2018: Science Translational Medicine
Marika Pane, Giorgia Coratti, Claudia Brogna, Elena Stacy Mazzone, Anna Mayhew, Lavinia Fanelli, Sonia Messina, Adele D'Amico, Michela Catteruccia, Marianna Scutifero, Silvia Frosini, Valentina Lanzillotta, Giulia Colia, Filippo Cavallaro, Enrica Rolle, Roberto De Sanctis, Nicola Forcina, Roberta Petillo, Andrea Barp, Alice Gardani, Antonella Pini, Giulia Monaco, Maria Grazia D'Angelo, Riccardo Zanin, Gian Luca Vita, Claudio Bruno, Tiziana Mongini, Federica Ricci, Elena Pegoraro, Luca Bello, Angela Berardinelli, Roberta Battini, Valeria Sansone, Emilio Albamonte, Giovanni Baranello, Enrico Bertini, Luisa Politano, Maria Pia Sormani, Eugenio Mercuri
The aim of the study was to establish 24 month changes in upper limb function using a revised version of the performance of upper limb test (PUL 2.0) in a large cohort of ambulant and non-ambulant boys with Duchenne muscular dystrophy and to identify possible trajectories of progression. Of the 187 patients studied, 87 were ambulant (age range: 7-15.8 years), and 90 non-ambulant (age range: 9.08-24.78). The total scores changed significantly over time (p<0.001). Non-ambulant patients had lower total scores at baseline (mean 19...
2018: PloS One
Emilio Carrizosa, Vanesa Guerrero, Daniel Hardt, Dolores Romero Morales
In this article we develop a novel online framework to visualize news data over a time horizon. First, we perform a Natural Language Processing analysis, wherein the words are extracted, and their attributes, namely the importance and the relatedness, are calculated. Second, we present a Mathematical Optimization model for the visualization problem and a numerical optimization approach. The model represents the words using circles, the time-varying area of which displays the importance of the words in each time period...
June 2018: Big Data
Emilio Sudy, Francisco Urbina
We describe a case of unilateral acne which appeared after an episode of facial nerve palsy. An 18-year-old female patient presented with papules and pustules predominantly located on the side where the facial paralysis occurred. The patient suffered right facial paralysis, which was treated with prednisone and kinesiotherapy with massages, electrostimulation, and infrared light. Two weeks later, acne lesions appeared in the area affected by the paralysis. As suggested in other cases of paralysis, including cases of Parkinson's disease and spinal cord injury, an increased sebum excretion rate and the immobility of the affected area are most likely what caused the unilateral acne lesions...
June 2018: Anais Brasileiros de Dermatologia
Francesco Ursini, Emilio Russo, Roberto De Giorgio, Giovambattista De Sarro, Salvatore D'Angelo
Psoriatic arthritis (PsA) is a chronic inflammatory disease of joints, tendon sheaths, and entheses affecting patients with established skin psoriasis, or, less frequently, patients without a personal history of psoriasis with a positive familial history. Many treatment options are now available to deal with the different aspects of the disease, including traditional and biological disease-modifying antirheumatic drugs and the recently released targeted synthetic disease-modifying antirheumatic drugs. However, ~40% of patients still fail to achieve a meaningful clinical response to first-line biologic therapy advocating the development of novel medications...
2018: Therapeutics and Clinical Risk Management
Jordi Adamuz, Maribel González-Samartino, Emilio Jiménez-Martínez, Marta Tapia-Pérez, María-Magdalena López-Jiménez, María-José Ruiz-Martínez, Hugo Rodríguez-Fernández, Pilar Delgado-Hito, Maria-Eulàlia Juvé-Udina
PURPOSE: To determine the frequency of care complexity individual factors documented in the nursing assessment and to identify the risk factors associated with hospital readmission within 30 days of hospital discharge. DESIGN: Observational analysis of a retrospective cohort at a 700-bed university hospital in Barcelona, Spain. A total of 16,925 adult patient admissions to a ward or intermediate care units were evaluated from January to December 2016. Most patients were admitted due to cardiocirculatory and respiratory disorders (29...
June 19, 2018: Journal of Nursing Scholarship
Gregorio P Milani, Jaap W Groothoff, Federica A Vianello, Emilio F Fossali, Fabio Paglialonga, Sivia Consolo, Alberto Edefonti, Dario Consonni, Dewi van Harskamp, Johannes B van Goudoever, Henk Schierbeek, Carlo Agostoni, Michiel J S Oosterveld
OBJECTIVES: Alterations in body compositions are strongly associated with poor outcomes in end-stage renal disease patients. Hence, assessment of lean body mass is crucial for clinically monitoring these patients. The use of multi-frequency bioimpedance spectroscopy measurements have also been advocated, but their usefulness in children is questioned. We investigated whether their application is appropriate for lean body mass measurement in pediatric patients receiving chronic dialysis...
June 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
Miguel Angel Benítez-Rosario, Inmaculada Rosa-González, Enrique González-Dávila, Emilio Sanz
PURPOSE: We assessed the effects of subcutaneous-endovenous fentanyl on dyspnoea in a cohort of advanced cancer patients. METHODS: We performed a retrospective study in a cohort of advanced cancer patients with dyspnoea at rest who received subcutaneous or intravenous fentanyl. Patients with no shortness of breath at rest or at minimal exertion, no rescue doses per 24 h, were deemed to be responders to fentanyl. The period of assessment was 6 days from the beginning of fentanyl treatment...
June 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Francesco Ursini, Emilio Russo, Gianluca Pellino, Salvatore D'Angelo, Agostino Chiaravalloti, Giovambattista De Sarro, Roberto Manfredini, Roberto De Giorgio
Metformin ( dimethyl biguanide ) is a synthetic derivative of guanidine, isolated from the extracts of Galega officinalis , a plant with a prominent antidiabetic effect. Since its discovery more than 50 years ago, metformin represents a worldwide milestone in treatment of patients with type 2 diabetes (T2D). Recent evidence in humans indicates novel pleiotropic actions of metformin which span from its consolidated role in T2D management up to various regulatory properties, including cardio- and nephro-protection, as well as antiproliferative, antifibrotic, and antioxidant effects...
2018: Frontiers in Immunology
Antonio Chiappa, Emilio Bertani, Gabriella Pravettoni, Andrew Paul Zbar, Diego Foschi, Giuseppe Spinoglio, Bernardo Bonanni, Gianluca Polvani, Federico Ambrogi, Maria Laura Cossu, Carlo Ferrari, Marco Venturino, Cristiano Crosta, Luca Bocciolone, Roberto Biffi
To analyze treatment and survival in a series of resected patients with primary or recurrent retroperitoneal sarcoma (RPS) treated and prospectively followed at a single institution. Between July 1994 and December 2015, 89 patients (36 M, 53 F; mean age 60 years, range 25-79) were evaluated. For the purpose of analysis, complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Eighty-three out of the 89 patients (93%), 46 of whom affected by primary RPS, and 37 by recurrent RPS, underwent surgical exploration...
April 2018: Indian Journal of Surgery
Carlo Cosimo Campa, Jean Piero Margaria, Abhishek Derle, Marco Del Giudice, Maria Chiara De Santis, Luca Gozzelino, Francesca Copperi, Carla Bosia, Emilio Hirsch
Directional transport of recycling cargo from early endosomes (EE) to the endocytic recycling compartment (ERC) relies on phosphatidylinositol 3-phosphate (PtdIns(3)P) hydrolysis and activation of the small GTPase Rab11. However, how these events are coordinated is yet unclear. By using a novel genetically-encoded FRET biosensor for Rab11, we report that generation of endosomal PtdIns(3)P by the clathrin-binding phosphoinositide 3-kinase class 2 alpha (PI3K-C2α) controls the activation of Rab11. Active Rab11, in turn, prompts the recruitment of the phosphatidylinositol 3-phosphatase myotubularin 1 (MTM1), eventually enabling the release of recycling cargo from the EE and its delivery toward the ERC...
June 18, 2018: Nature Chemical Biology
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