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https://www.readbyqxmd.com/read/28634407/analysis-of-survival-and-hatching-transcriptomes-from-potato-cyst-nematodes-globodera-rostochiensis-and-g-pallida
#1
Marc-Olivier Duceppe, Joël Lafond-Lapalme, Juan Emilio Palomares-Rius, Michaël Sabeh, Vivian Blok, Peter Moffett, Benjamin Mimee
Potato cyst nematodes (PCNs), Globodera rostochiensis and G. pallida, cause important economic losses. They are hard to manage because of their ability to remain dormant in soil for many years. Although general knowledge about these plant parasitic nematodes has considerably increased over the past decades, very little is known about molecular events involved in cyst dormancy and hatching, two key steps of their development. Here, we have studied the progression of PCN transcriptomes from dry cysts to hatched juveniles using RNA-Seq...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632830/-declaration-of-the-chilean-academy-of-medicine-of-law-20-850-on-clinical-trials-of-pharmaceutical-products-and-medical-devices-and-of-the-bylaw-that-will-regulate-its-application
#2
Gloría López, Gloría Valdés, Emilio Roessler, Vicente Valdivieso
In Chile, high cost treatments required by selected medical conditions are financed by the State, according to Law 20.850. A bylaw under discussion by the Senate regulates clinical trials, posing complex issues that will endanger local interest in front-line research: 1) The exclusive and mandatory control bestowed to the Institute of Public Health during all stages of the trials and also the surveillance of institutions performing clinical trials, overriding their Clinical Research Review Boards; 2) The 10 year period during which any adverse event is assumed to have been caused by the medication or devise evaluated by the trial, unless the contrary is proven in a judicial process; 3) Individuals submitted to the trials are entitled to free post trial access to the treatment received during the study, financed by the trial supporting entities and as long as the drug or devise is considered to be useful...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28629076/effect-of-acute-and-long-term-administration-of-gold-nanoparticles-on-biochemical-parameters-in-rat-brain
#3
Gabriela K Ferreira, Eria Cardoso, Francieli Silva Vuolo, Letícia Selinger Galant, Monique Michels, Cinara L Gonçalves, Gislaine Tezza Rezin, Felipe Dal-Pizzol, Roberto Benavides, Gabriel Alonso-Núñez, Vanessa Moraes Andrade, Emilio L Streck, Marcos Marques da Silva Paula
The present study investigated stress oxidative parameters and activities of enzymes of the energy metabolism in various brain structures. Rats were subjected to acute and long-term administration of gold nanoparticles (GNPs) with mean diameters of 10nm and 30nm. Adult (60days old) male Wistar rats received a single intraperitoneal injection (acute administration; 70μg·kg(-1)) or repeated injections once daily for 28days (long-term administration; 70μg·kg(-1)) of saline solution or GNPs (10nm or 30nm). Twenty-four hours after administration of the final dose, the animals were killed and the cerebral structures were isolated for enzyme analysis...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628772/prognostic-impact-of-proliferation-for-resected-early-stage-pure-invasive-lobular-breast-cancer-cut-off-analysis-of-ki67-according-to-histology-and-clinical-validation
#4
Luisa Carbognin, Isabella Sperduti, Alessandra Fabi, Maria Vittoria Dieci, Dzenete Kadrija, Gaia Griguolo, Sara Pilotto, Valentina Guarneri, Ilaria Zampiva, Matteo Brunelli, Enrico Orvieto, Rolando Nortilli, Elena Fiorio, Veronica Parolin, Erminia Manfrin, Anna Caliò, Cecilia Nisticò, Francesca Pellini, Aldo Scarpa, Giovanni Paolo Pollini, Pierfranco Conte, Giampaolo Tortora, Emilio Bria
INTRODUCTION: The intent of this analysis was to investigate and validate the prognostic potential of Ki67 in a multi-center series of patients affected by early stage 'pure' invasive lobular carcinoma (ILC). METHODS: Clinical-pathological data of patients affected by ILC were correlated with overall survival and disease-free survival (OS/DFS); data from a parallel invasive ductal carcinoma (IDC) patients' cohort were gathered as well. The maximally selected Log-Rank statistics analysis was applied to Ki67 continuous variable to estimate the appropriate cut-off...
June 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28628669/the-global-fund-in-china-multidrug-resistant-tuberculosis-nationwide-programmatic-scale-up-and-challenges-to-transition-to-full-country-ownership
#5
Lixia Wang, Renzhong Li, Caihong Xu, Hui Zhang, Yunzhou Ruan, Mingting Chen, Dongmei Wang, Emilio Dirlikov, Xin Du, Jin Zhao, Yanlin Zhao, ShengFen Wang, Yuhong Liu, Liang Li, Dennis Falzon, Yanni Sun, Yu Wang, Bernhard Schwartländer, Fabio Scano
China has the world's second largest burden of multidrug-resistant tuberculosis (MDR-TB; resistance to at least isoniazid and rifampicin), with an estimated 57,000 cases (range, 48,000-67,000) among notified pulmonary TB patients in 2015. During October 1, 2006-June 30, 2014, China expanded MDR-TB care through a partnership with the Global Fund to Fight AIDS, Tuberculosis, and Malaria (Global Fund). We analyzed data on site expansion, patient enrolment, treatment outcomes, cost per patient, and overall programme expenditure...
2017: PloS One
https://www.readbyqxmd.com/read/28627236/estrogen-receptor-1-esr1-gene-polymorphisms-and-obesity-phenotypes-in-a-population-of-young-adults
#6
María Correa-Rodríguez, Jacqueline Schmidt-RioValle, Emilio González-Jiménez, Blanca Rueda-Medina
Obesity is considered an increasingly serious health problem determined by multiple genetic and environmental factors. Estrogens have been found to play a major role in body weight and adiposity regulation through estrogen receptor 1 ( ESR1). The aim of this study was to determine whether genotype and haplotype frequencies of ESR1 polymorphisms are associated with body composition measures in a population of 572 young adults. A lack of significant association between genotypes of ESR1 gene polymorphisms and obesity phenotypes was seen after adjustment for confounding factors...
June 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28627194/s%C3%A3-ndrome-metab%C3%A3-lico-y-riesgo-cardiovascular-en-la-poblaci%C3%A3-n-diab%C3%A3-tica-de-el-hierro-islas-canarias
#7
M Candelaria Martín-González, Ana María Torres-Vega, Emilio González-Reimers, Geraldine Quintero-Platt, Camino Fernández-Rodríguez, Julio Alvisa-Negrín, Adnan Hawari-Meilud, Francisco Santolaria-Fernández
Introducción: en Canarias existe una elevada prevalencia de factores de riesgo vascular, superior a la del resto de España.Objetivo: analizar las características clínicas de 300 adultos diabéticos tipo II de El Hierro, en el Archipiélago Canario.Métodos: los pacientes fueron valorados en la Unidad de Medicina Interna del hospital entre 1982 a 2010, y seguidos hasta diciembre de 2014 o hasta su fallecimiento. La muestra se compone de 154 mujeres y 156 hombres (52%).Resultados: la edad media fue de 66...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28626759/sertraline-induces-toxicity-and-behavioral-alterations-in-planarians
#8
Isabela Salvador Thumé, Marcos Emílio Frizzo
Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms. We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently are widely used as an animal model in neuropharmacological studies. Planarians treated with 10 µM sertraline showed a rapid reduction in their spontaneous movement until they became completely motionless and then showed a series of asynchronous paroxysms (seizures) followed by progressive tissue damage, beginning 48 h after the sertraline treatment, and died approximately 72 h later...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28626615/getting-off-to-a-good-start-genetic-evaluation-of-the-ex-situ-conservation-project-of-the-critically-endangered-montseny-brook-newt-calotriton-arnoldi
#9
Emilio Valbuena-Ureña, Anna Soler-Membrives, Sebastian Steinfartz, Mònica Alonso, Francesc Carbonell, Raquel Larios-Martín, Elena Obon, Salvador Carranza
Ex situ management strategies play an important role in the conservation of threatened species when the wild survival of the species cannot be ensured. Molecular markers have become an outstanding tool for the evaluation and management of captive breeding programs. Two main genetic objectives should be prioritized when planning breeding programs: the maintenance of maximum neutral genetic diversity, and to obtain "self-sustaining" captive populations. In this study, we use 24 microsatellite loci to analyze and evaluate the genetic representativity of the initial phases of the captive breeding program of the Montseny brook newt, Calotriton arnoldi, an Iberian endemic listed as Critically Endangered...
2017: PeerJ
https://www.readbyqxmd.com/read/28625147/adverse-drug-reactions-related-to-drug-administration-in-hospitalized-patients
#10
Luca Gallelli, Antonio Siniscalchi, Caterina Palleria, Laura Mumoli, Orietta Staltari, Aida Squillace, Francesca Maida, Emilio Russo, Santo Gratteri, Giovambattista De Sarro
INTRODUCTION: Drug treatment may be related with the development of adverse drug reactions (ADRs). AIM: Here, we evaluated the ADRs in patients admitted to Catanzaro Hospital. METHODS: After we obtained the approval by local Ethical Committee, we performed a retrospective study on clinical records from March 01, 2013 to April30, 2015. The association between drug and ADR or between drug and drug-drug-interactions (DDIs) was evaluated using the Naranjo's probability scale and Drug Interaction Probability Scale (DIPS), respectively...
June 15, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28623263/probing-spermiogenesis-a-digital-strategy-for-mouse-acrosome-classification
#11
Alessandro Taloni, Francesc Font-Clos, Luca Guidetti, Simone Milan, Miriam Ascagni, Chiara Vasco, Maria Enrica Pasini, Maria Rosa Gioria, Emilio Ciusani, Stefano Zapperi, Caterina A M La Porta
Classification of morphological features in biological samples is usually performed by a trained eye but the increasing amount of available digital images calls for semi-automatic classification techniques. Here we explore this possibility in the context of acrosome morphological analysis during spermiogenesis. Our method combines feature extraction from three dimensional reconstruction of confocal images with principal component analysis and machine learning. The method could be particularly useful in cases where the amount of data does not allow for a direct inspection by trained eye...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621922/selective-organic-contacts-for-methyl-ammonium-lead-iodide-mapi-perovskite-solar-cells-influence-of-layer-thickness-on-carriers-extraction-and-carriers-lifetime
#12
Ilario Gelmetti, Lydia Cabau, Núria F Montcada, Emilio Palomares
We have fabricated MAPI solar cells using as selective contacts PEDOT:PSS polymer for holes and PCBM-C70 fullerene derivative for electrons. The thickness of MAPI, PCBM-C70, and PEDOT:PSS layers has been varied in order to evaluate the contribution of each layer to the final device performance. We have measured the devices capacitance under illumination and the charge carrier's lifetime using photoinduced time-resolved techniques. The results show that in this kind of devices the limiting layer is the PCBM-C70 due to its relative reduced mobility compared to PEDOT:PSS that makes the control of the fullerene thickness crucial for device optimization...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28621040/bioactive-neolignans-and-other-compounds-from-magnolia-grandiflora-l-isolation-and-antiplasmodial-activity
#13
Abdul Latif, Yongle Du, Seema R Dalal, Emilio F Merino, Maria B Cassera, Michael Goetz, David G I Kingston
Bioassay-guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 - 8) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D and 2D NMR data. Known compounds were identified by comparison of (1) H NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with IC50 values of 2.8 ± 0.1 and 3.4 ± 0.1 μM, respectively. Weak antiplasmodial activity was recorded for compounds 1, 2, 5, 6, 7 and 8, with IC50 values of 38 ± 2, 23 ± 2, 16...
June 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28617200/exposure-to-pfoa-and-pfos-and-fetal-growth-a-critical-merging-of-toxicological-and-epidemiological-data
#14
Eva Negri, Francesca Metruccio, Valentina Guercio, Luca Tosti, Emilio Benfenati, Rossella Bonzi, Carlo La Vecchia, Angelo Moretto
Toxicological and epidemiological evidence on the association between perfluorooctanoic acid (PFOA) or perfluorooctane sulfonic acid (PFOS) and birth/fetal weight was assessed. An extensive search for toxicological information in rats and mice, and a systematic search for epidemiological evidence were conducted. The linear regression coefficient (LRC) of birth weight (BrthW) on PFOA/PFOS was considered, and separate random effects meta-analyses for untransformed (i.e. not mathematically transformed) and log-transformed values were performed...
July 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28614683/single-nephron-glomerular-filtration-rate-in-healthy-adults
#15
Aleksandar Denic, Jerry Mathew, Lilach O Lerman, John C Lieske, Joseph J Larson, Mariam P Alexander, Emilio Poggio, Richard J Glassock, Andrew D Rule
BACKGROUND: The glomerular filtration rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown. METHODS: We identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a computed tomographic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement of the GFR during donor evaluation and who underwent a kidney biopsy at donation...
June 15, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28613869/effect-of-different-elicitors-and-pre-harvest-day-application-on-the-content-of-phytochemicals-and-antioxidant-activity-of-butterhead-lettuce-lactuca-sativa-var-capitata-produced-under-hydroponic-conditions
#16
Jesus Omar Moreno-Escamilla, Emilio Alvarez-Parrilla, Laura A de la Rosa, José Alberto Núñez-Gastélum, Gustavo A González-Aguilar, Joaquin Rodrigo-Garcia
The effect of four elicitors on phytochemical content in two varieties of lettuce was evaluated. The best pre-harvest day for application of each elicitor was chosen. Solutions of arachidonic acid (AA), salicylic acid (SA), methyl jasmonate (MJ), and Harpin protein (HP) were applied by foliar aspersion on lettuce leaves while cultivated under hydroponic conditions. Application of elicitors was done at 15, 7, 5, 3 or 1 day before harvest. Green lettuce showed the highest increase in phytochemical content when elicitors (AA, SA, and HP) were applied on day 7 before harvest...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28611113/active-paraoxonase-1-is-synthesised-throughout-the-internal-boar-genital-organs
#17
Isabel Barranco, Cristina Perez-Patiño, Asta Tvarijonaviciute, Inmaculada Parrilla, Alejandro Vicente-Carrillo, Manuel Alvarez-Rodriguez, Jose J Ceron, Emilio Martinez, Heriberto Rodriguez-Martinez, Jordi Roca
The paraoxonase type 1 (PON1) is an enzyme with antioxidant properties recently identified in the seminal plasma (SP) of several species, including the porcine. The aims of the present study were to (1) describe the inmunohistochemical localization of PON1 in the genital organs of fertile boars and (2) evaluate the relationship among PON1 activity and high-density lipoprotein cholesterol (HDL-C) concentration in fluids of the boar genital organs. Immunohistochemical analysis demonstrated that PON1 was present in testis (specifically in Leydig cells, blood vessels, spermatogonia and elongated spermatids), epididymis (specifically in the cytoplasm of the principal epithelial cells, luminal secretion and in the surrounding smooth muscle) and the lining epithelia of the accessory sexual glands (cytoplasmic location in the prostate and membranous in the seminal vesicle and bulbourethral glands)...
June 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28610690/investigating-output-and-energy-variations-and-their-relationship-to-delivery-qa-results-using-statistical-process-control-for-helical-tomotherapy
#18
Diana Binny, Emilio Mezzenga, Craig M Lancaster, Jamie V Trapp, Tanya Kairn, Scott B Crowe
The aims of this study were to investigate machine beam parameters using the TomoTherapy quality assurance (TQA) tool, establish a correlation to patient delivery quality assurance results and to evaluate the relationship between energy variations detected using different TQA modules. TQA daily measurement results from two treatment machines for periods of up to 4years were acquired. Analyses of beam quality, helical and static output variations were made. Variations from planned dose were also analysed using Statistical Process Control (SPC) technique and their relationship to output trends were studied...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28607844/perforator-flaps-covering-alloplastic-materials-in-full-thickness-chest-wall-defects-reconstruction-a-safe-option
#19
Cristina Aubá, Álvaro Cabello, Emilio García-Tutor, Antonio Vila, Shan Shan Qiu, Wenceslao Torre
Large full-thickness chest wall reconstruction requires an alloplastic material to ensure chest wall stability, as well as a flap that provides good soft-tissue coverage. The choice not to use perforator flaps over any mesh or inert material is often based on the concern that the vascularization would be inadequate. However, perforator flaps have shown good results in several reconstructive fields, minimizing donor-site morbidity and offering versatility when local tissues are unavailable or affected by radiotherapy...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28604715/the-mof-driven-synthesis-of-supported-palladium-clusters-with-catalytic-activity-for-carbene-mediated-chemistry
#20
Francisco R Fortea-Pérez, Marta Mon, Jesús Ferrando-Soria, Mercedes Boronat, Antonio Leyva-Pérez, Avelino Corma, Juan Manuel Herrera, Dmitrii Osadchii, Jorge Gascon, Donatella Armentano, Emilio Pardo
The development of catalysts able to assist industrially important chemical processes is a topic of high importance. In view of the catalytic capabilities of small metal clusters, research efforts are being focused on the synthesis of novel catalysts bearing such active sites. Here we report a heterogeneous catalyst consisting of Pd4 clusters with mixed-valence 0/+1 oxidation states, stabilized and homogeneously organized within the walls of a metal-organic framework (MOF). The resulting solid catalyst outperforms state-of-the-art metal catalysts in carbene-mediated reactions of diazoacetates, with high yields (>90%) and turnover numbers (up to 100,000)...
June 12, 2017: Nature Materials
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