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https://www.readbyqxmd.com/read/29168673/the-role-of-dalbavancin-in-the-multi-disciplinary-management-of-wound-infections-in-orthopaedic-surgery
#1
Fabio Arena, Emilio Romanini, Elia Rosi, Carlo Salomone, Gabriele Tucci, Ciro Pempinello, Massimo Fantoni
Antimicrobial resistance is continuously increasing among bacterial clinical isolates (especially methicillin resistance in Staphylococcus aureus, MRSA), negatively impacting on outcomes of patients with Surgical Site Infections (SSIs). A multi-disciplinary team work is essential for SSIs prevention and for the choice of antibiotic therapy of orthopaedic SSIs. In particular, an Antibiotic Stewardship (AS) approach is recommended for preserving the activity of old and new antimicrobials. Dalbavancin is a novel antimicrobial agent, belonging to the lipoglycopeptides family, recently approved by FDA for the treatment of ABSSSIs (Acute Bacterial Skin and Skin Structure Infections) and can be considered as a candidate for the treatment of orthopaedic superficial SSIs...
November 23, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29166107/simulations-of-water-nano-confined-between-corrugated-planes
#2
Jon Zubeltzu, Emilio Artacho
Water confined to nanoscale widths in two dimensions between ideal planar walls has been the subject of ample study, aiming at understanding the intrinsic response of water to confinement, avoiding the consideration of the chemistry of actual confining materials. In this work, we study the response of such nanoconfined water to the imposition of a periodicity in the confinement by means of computer simulations, both using empirical potentials and from first-principles. For that we propose a periodic confining potential emulating the atomistic oscillation of the confining walls, which allows varying the lattice parameter and amplitude of the oscillation...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29164812/inter-and-intraspecific-variability-of-nitrogenated-compounds-in-gorgonian-corals-via-application-of-a-fast-one-step-analytical-protocol
#3
Chiara Samorì, Federica Costantini, Paola Galletti, Emilio Tagliavini, Marco Abbiati
Gorgonian corals play a structural role in temperate and tropical biogenic reefs, forming animal forests and creating biodiversity hot spots. In the Mediterranean Sea, slow-growing and long-lived gorgonian species are threatened by human disturbances and global environmental changes and concern about their conservation is rising. Alkaloid metabolites have proven to be essential in protecting these species from environmental stressors.. Traditional profiling methodologies to detect these metabolites require a large quantity of living tissue...
November 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29161354/p140cap-regulates-gabaergic-synaptogenesis-and-development-of-hippocampal-inhibitory-circuits
#4
Isabella Russo, Daniela Gavello, Elisabetta Menna, David Vandael, Carola Veglia, Noemi Morello, Irene Corradini, Elisa Focchi, Annalisa Alfieri, Costanza Angelini, Federico Tommaso Bianchi, Alessandro Morellato, Andrea Marcantoni, Marco Sassoè-Pognetto, Matteo Maria Ottaviani, Latefa Yekhlef, Maurizio Giustetto, Stefano Taverna, Valentina Carabelli, Michela Matteoli, Emilio Carbone, Emilia Turco, Paola Defilippi
The neuronal scaffold protein p140Cap was investigated during hippocampal network formation. p140Cap is present in presynaptic GABAergic terminals and its genetic depletion results in a marked alteration of inhibitory synaptic activity. p140Cap-/- cultured neurons display higher frequency of miniature inhibitory postsynaptic currents (mIPSCs) with no changes of their mean amplitude. Consistent with a potential presynaptic alteration of basal GABA release, p140Cap-/- neurons exhibit a larger synaptic vesicle readily releasable pool, without any variation of single GABAA receptor unitary currents and number of postsynaptic channels...
November 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29161309/dronedarone-produces-early-regression-of-myocardial-remodelling-in-structural-heart-disease
#5
Begoña Quintana-Villamandos, Jose Juan Gomez de Diego, María Jesús Delgado-Martos, David Muñoz-Valverde, María Luisa Soto-Montenegro, Manuel Desco, Emilio Delgado-Baeza
BACKGROUND AND AIMS: Left ventricular hypertrophy (LVH) in hypertension is associated with a greater risk of sustained supraventricular/atrial arrhythmias. Dronedarone is an antiarrhythmic agent that was recently approved for the treatment of atrial fibrillation. However, its effect on early regression of LVH has not been reported. We tested the hypothesis that short-term administration of dronedarone induces early regression of LVH in spontaneously hypertensive rats (SHRs). METHODS: Ten-month-old male SHRs were randomly assigned to an intervention group (SHR-D), where animals received dronedarone treatment (100 mg/kg) for a period of 14 days, or to a control group (SHR) where rats were given vehicle...
2017: PloS One
https://www.readbyqxmd.com/read/29160547/ultrasound-biomicroscopy-in-acetazolamide-induced-myopic-shift-with-appositional-angle-closure
#6
Julio Daniel Grigera, Emilio Daniel Grigera
We report a case of a 49-year-old female who presented to the emergency department with blurred vision and vomiting, hours after taking two tablets of 250 mg of acetazolamide. The anterior chamber was bilaterally flat, with normal intraocular pressure in both eyes. An ultrasound biomicroscopic (UBM) examination showed bilateral ciliary effusion and complete appositional angle closure in all quadrants. Acetazolamide-induced bilateral angle closure was diagnosed. Steroid and cycloplegic therapy were initiated, and acetazolamide was discontinued...
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29160398/topographic-and-chemical-analysis-of-reciprocating-and-rotary-instruments-surface-after-continuous-use
#7
Mariana Mena Barreto Bastos, Aida Rene Assayag Hanan, Ana Mena Barreto Bastos, André Augusto Franco Marques, Lucas da Fonseca Roberti Garcia, Emílio Carlos Sponchiado
This study aimed at evaluating the changes in surface characteristics and NiTi content of reciprocating and rotary instruments after continuous use. Thirty brand-new instruments were assigned to 3 groups (n=10): PNX1 Group - ProTaper Next system - instrument X1; PNX2 Group - ProTaper Next system - instrument X2 and WO Group - WaveOne system - Primary instrument 25.08. The instruments were used to prepare 60 simulated root canals. Analysis of surface characteristics by scanning electron microscopy (SEM) and chemical analysis of Ni and Ti content by energy-dispersive spectroscopy (EDS) were performed before and after the first and third use of the instruments...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160213/cutaneous-metastases-of-internal-malignancies-an-experience-from-a-single-institution
#8
Elena Guanziroli, Antonella Coggi, Luigia Venegoni, Daniele Fanoni, Giulia Ercoli, Francesca Boggio, Stefano Veraldi, Emilio Berti, Raffaele Gianotti, Stefano Ferrero, Alessandro Del Gobbo
BACKGROUND: Cutaneous metastases represent 2% of all skin tumours. Their recognition can be challenging, as they may present with different clinical features, with consequent frequent delay and failure in diagnosis. OBJECTIVES: To review our series of cutaneous metastatic lesions, analyse their frequency according to patient gender, histotype, localization of the primary tumour, and site of cutaneous metastasis, and correlate this data with clinicopathological parameters...
November 21, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29158371/perception-of-curability-among-advanced-cancer-patients-an-international-collaborative-study
#9
Sriram Yennurajalingam, Luis Fernando Rodrigues, Omar Shamieh, Colombe Tricou, Marilène Filbet, Kyaw Naing, Akhileshwaran Ramaswamy, Pedro Emilio Perez-Cruz, Mary Jocelyn S Bautista, Sofia Bunge, Mary Ann Muckaden, Vikash Sewram, Sarah Fakrooden, Antonio Tejedor Noguera, Shobha S Rao, Diane Liu, Minjeong Park, Janet L Williams, Zhanni Lu, Hilda Cantu, David Hui, Suresh K Reddy, Eduardo Bruera
BACKGROUND: There are limited data on illness understanding and perception of cure among advanced cancer patients around the world. The aim of the study was to determine the frequency and factors associated with inaccurate perception of curability among advanced cancer patients receiving palliative care across the globe. MATERIALS AND METHODS: Secondary analysis of a study to understand the core concepts in end-of-life care among advanced cancer patients receiving palliative care from 11 countries across the world...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29158365/phase-ii-trial-using-a-combination-of-oxaliplatin-capecitabine-and-celecoxib-with-concurrent-radiation-for-newly-diagnosed-resectable-rectal-cancer
#10
Emilio P Araujo-Mino, Yehuda Z Patt, Cristina Murray-Krezan, Joshua A Hanson, Pranshu Bansal, Ben J Liem, Ashwani Rajput, M Houman Fekrazad, Glenory Heywood, Fa Chyi Lee
LESSONS LEARNED: Colorectal cancers exhibit a high level of cyclooxygenase-2 (COX-2) expression with strong preclinical rationale for improved clinical outcomes with COX-2 inhibition. Celecoxib is a COX-2 inhibitor and we have shown that it can be safely combined with capecitabine and oxaliplatin as part of neoadjuvant treatment with radiation therapy (RT) in rectal cancer.There was a significant improvement in skin toxicity with this combination as compared with historical data. Considering the field has moved on to single-agent capecitabine, we believe future trials with capecitabine and celecoxib hold potential...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29157900/a-practical-molecular-identification-of-nonfermenting-gram-negative-bacteria-from-cystic-fibrosis
#11
Carolina Paulino da Costa Capizzani, Natália Candido Caçador, Elizabeth Andrade Marques, Carlos Emílio Levy, Ludmilla Tonani, Lidia Alice Gomes Monteiro Marin Torres, Ana Lúcia da Costa Darini
Identification of nonfermenting Gram-negative bacteria (NFGNB) of cystic fibrosis patients is hard and misidentification could affect clinical outcome. This study aimed to propose a scheme using polymerase chain reaction to identify NFGNB. This scheme leads to reliable identification within 3 days in an economically viable manner when compared to other methods.
November 4, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29155058/foxo-1-contributes-to-the-efficacy-of-the-combination-of-the-xpo1-inhibitor-selinexor-and-cisplatin-in-ovarian-carcinoma-preclinical-models
#12
Cristina Corno, Simone Stucchi, Michelandrea De Cesare, Nives Carenini, Serena Stamatakos, Emilio Ciusani, Lucia Minoli, Eugenio Scanziani, Christian Argueta, Yosef Landesman, Nadia Zaffaroni, Laura Gatti, Paola Perego
The XPO1/CRM1 inhibitor selinexor (KPT-330), is currently being evaluated in multiple clinical trials as an anticancer agent. XPO1 participates in the nuclear export of FoxO-1, which we previously found to be decreased in platinum-resistant ovarian carcinoma. The aim of this study was to determine whether enriching FoxO-1 nuclear localization using selinexor would increase ovarian cancer cell sensitivity to cisplatin. Selinexor, as a single agent, displayed a striking antiproliferative effect in different ovarian carcinoma cell lines...
November 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29153968/effect-of-contract-research-organization-bureaucracy-in-clinical-trial-management-a%C3%A2-model-from-lung-cancer
#13
Elisa Gobbini, Sara Pilotto, Giulia Pasello, Valentina Polo, Massimo Di Maio, Francesca Arizio, Domenico Galetta, Patrizia Petrillo, Rita Chiari, Roberta Matocci, Alessandro Di Costanzo, Teresa Severina Di Stefano, Massimo Aglietta, Celeste Cagnazzo, Isabella Sperduti, Emilio Bria, Silvia Novello
INTRODUCTION: Contract research organization (CRO) support is largely included in clinical trial management, although its effect in terms of time savings and benefit has not yet been quantified. We performed a retrospective multicenter analysis of lung cancer trials to explore differences in term of trial activation timelines and accrual for studies with and without CRO involvement. MATERIALS AND METHODS: Results regarding study timelines from feasibility data to first patient enrollment were collected from 7 Italian thoracic oncology departments...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29152643/differences-in-tibial-shape-among-the-prehispanic-inhabitants-from-gomera-punta-azul-el-hierro-and-gran-canaria-canary-islands
#14
Emilio González-Reimers, María Castañeyra-Ruiz, Aioze Trujillo-Mederos, Matilde Arnay-de-la-Rosa
The Canary Archipelago was colonized by North African Berbers who arrived at the Islands in the first millenium BC. Although it was classically considered that the prehispanic population was more or less uniform, recent genetic analysis has disclosed that some differences did exist between inhabitants of the different islands. From pure anthropometrical point of view, detailed inspection of some bones such as tibiae of prehispanic inhabitants of different islands allow the detection of some differences in tibial shape, especially regarding the relative size of both the proximal and distal thirds of these bones...
November 14, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29151992/aerococcus-urinae-and-aerococcus-sanguinicola-susceptibility-testing-of-120-isolates-to-six-antimicrobial-agents-using-disk-diffusion-eucast-etest-and-broth-microdilution-techniques
#15
Derya Carkaci, Xiaohui C Nielsen, Kurt Fuursted, Robert Skov, Ole Skovgaard, Emilio P Trallero, Reto Lienhard, Jenny Åhman, Erika Matuschek, Gunnar Kahlmeter, Jens J Christensen
Background: Aerococcus urinae and Aerococcus sanguinicola are relatively newcomers and emerging organisms in clinical and microbiological practice. Both species have worldwide been associated with urinary tract infections. More rarely cases of bacteremia/septicemia and infective endocarditis have been reported. Treatment options are therefore important. Just recently, European recommendations on susceptibility testing and interpretive criteria have been released. Objective: In this investigation 120 A...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29149822/olive-leaf-extracts-act-as-modulators-of-the-human-immune-response
#16
Thea Magrone, Anna Spagnoletta, Rosaria Salvatore, Manrico Magrone, Francesco Dentamaro, Matteo Antonio Russo, Graziana Difonzo, Carmine Summo, Francesco Caponio, Emilio Jirillo
BACKGROUND: Olive tree leaves have been used in the Mediterranean area as traditional medicine in virtue of their healthy effects. Olive leaf extracts (OLEs) contain higher amounts of polyphenols than those detected in the extra virgin olive oil and fruit. Several lines of evidence support the cardioprotective, anti-oxidant and anti-inflammatory activities exerted by OLEs. METHODS: Peripheral blood mononuclear cells (PBMCs) from twenty-five healthy donors were cultured in the presence of 3 μg of two OLE extracts, extract A (resuspended in water) and extract B (resuspended in 70% ethanol)...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29149744/bacterial-community-structure-along-the-subtidal-sandy-sediment-belt-of-a-high-arctic-fjord-kongsfjorden-svalbard-islands
#17
Conte Antonella, Papale Maria, Amalfitano Stefano, Mikkonen Anu, Rizzo Carmen, De Domenico Emilio, Michaud Luigi, Lo Giudice Angelina
Open fjords are subject to contrasting environmental conditions, owing to meltwater glacial inputs, terrestrial runoff, and marine water mass exchanges, which are exacerbated by anthropogenic and climate perturbations. Following a slope-dependent water circulation, the subtidal sandy sediment belt regulates the convergent transport of nutrients downward the fjord depths, and the effective entrapment of suspended particles and microorganisms. In this study, we aimed at testing how glacial and seawater inputs may influence the bacterial community structure of subtidal sand deposits in the Kongsfjorden...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29148148/an-integrative-translational-approach-to-study-heart-failure-with-preserved-ejection-fraction-a-position-paper-from-the-working-group-on-myocardial-function-of-the-european-society-of-cardiology
#18
REVIEW
Andre P Lourenço, Adelino F Leite-Moreira, Jean-Luc Balligand, Johann Bauersachs, Dana Dawson, Rudolf A de Boer, Leon J de Windt, Inês Falcão-Pires, Ricardo Fontes-Carvalho, Stefan Franz, Mauro Giacca, Denise Hilfiker-Kleiner, Emilio Hirsch, Christoph Maack, Manuel Mayr, Burkert Pieske, Thomas Thum, Carlo G Tocchetti, Dirk L Brutsaert, Stephane Heymans
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages...
November 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29146554/ingap-pp-effects-on-%C3%AE-cell-mass-and-function-are-related-to-its-positive-effect-on-islet-angiogenesis-and-vegfa-production
#19
Carolina Lisi Román, Bárbara Maiztegui, Héctor Del Zotto, Juan José Gagliardino, Luis Emilio Flores
Our aim was to determine whether islet angiogenesis and VEGFA production/release participate in the mechanism by which INGAP-PP enhances β-cell function and mass. We used two models: a) in vivo (normal rats injected with INGAP-PP for 10 days) and b) in vitro (normal islets cultured for 4 days with INGAP-PP, VEGFA, Rapamycin, and the specific VEGF-Receptor inhibitor, SU5416). INGAP-PP administration enhanced insulin secretion, β-cell mass, islet vascularization, and angiogenesis without affecting glucose homeostasis...
November 13, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29146065/post-thaw-boar-sperm-motility-is-affected-by-prolonged-storage-of-sperm-in-liquid-nitrogen-a-retrospective-study
#20
Junwei Li, Inmaculada Parrilla, Maria D Ortega, Emilio A Martinez, Heriberto Rodriguez-Martinez, Jordi Roca
Owing to the quick genetic turnover of the pig industry, most AI-boar sires live 2-3 yr, a period during which for 1-2 yr their semen is extended and used in liquid form for AI. Despite showing low cryosurvival, affecting fertility after AI, boar semen is frozen for easiness of transport overseas and reposition of valuable genetics. For the latter, semen is stored in liquid nitrogen (LN2, cryostorage) for many years, a controversial practice. Here we studied how length of cryostorage could affect sperm quality...
November 13, 2017: Cryobiology
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