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https://www.readbyqxmd.com/read/28746378/high-molecular-weight-adiponectin-homa-ir-ratio-as-a-biomarker-of-metabolic-syndrome-in-urban-multiethnic-brazilian-subjects
#1
Virgínia Genelhu de Abreu, Cyro José de Moraes Martins, Patricia Aguiar Cardoso de Oliveira, Emilio Antonio Francischetti
Metabolic syndrome (MetS) has an important epidemiological relevance due to its increasing prevalence and association with type 2 diabetes and cardiovascular disease. Insulin resistance is a core feature of the MetS. HOMA-IR is a robust clinical and epidemiological marker of MetS. Adiponectin is an adipokine with insulin-sensitizing and anti-inflammatory functions; its levels decrease as number of components of MetS increases. High-molecular weight adiponectin (HMWA) is the multimer responsible for the relationship of adiponectin with insulin sensitivity...
2017: PloS One
https://www.readbyqxmd.com/read/28745604/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibitors-a-new-drug-class-for-the-treatment-of-hypercholesterolemia
#2
Emilio Ortega Martínez de Victoria
No abstract text is available yet for this article.
August 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28745467/ictal-and-interictal-electroencephalogram-of-benign-infantile-seizures-associated-with-mild-gastroenteritis
#3
Alberto M Cappellari, Marta B Mazzoni, Emanuela A Laicini, Giuseppe Bertolozzi, Federica Vianello, Gregorio P Milani, Emilio F Fossali
No abstract text is available yet for this article.
October 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28745225/preface
#4
Emilio Jirillo
No abstract text is available yet for this article.
2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28743603/pre-and-post-natal-melatonin-administration-partially-regulates-brain-oxidative-stress-but-does-not-improve-cognitive-or-histological-alterations-in-the-ts65dn-mouse-model-of-down-syndrome
#5
Andrea Corrales, Eduardo B Parisotto, Verónica Vidal, Susana García-Cerro, Sara Lantigua, Marian Diego, Danilo Wilhem Filho, Emilio J Sanchez-Barceló, Carmen Martínez-Cué, Noemí Rueda
Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months...
July 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28743120/everolimus-in-combination-with-octreotide-lar-in-first-line-setting-for-patients-with-neuroendocrine-tumors-a-5-years-update
#6
Emilio Bajetta, Laura Catena, Sara Pusceddu, Francesca Spada, Claudio Iannacone, Italo Sarno, Giandomenico Di Menna, Lorenzo Dottorini, Anna Maria Marte
No abstract text is available yet for this article.
July 26, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28740203/homeostatic-left-heart-integration-and-disintegration-links-atrio-ventricular-covariation-s-dyshomeostasis-in-hypertrophic-cardiomyopathy
#7
Paolo Piras, Concetta Torromeo, Antonietta Evangelista, Stefano Gabriele, Giuseppe Esposito, Paola Nardinocchi, Luciano Teresi, Andrea Madeo, Michele Schiariti, Valerio Varano, Paolo Emilio Puddu
Left ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring in systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness about the entire left ventricle or left atrium revolution and on their deficiencies that take place in presence of hypertrophic cardiomyopathy...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739788/systematic-therapeutic-drug-monitoring-for-linezolid-variability-and-clinical-impact
#8
Alicia Galar, Maricela Valerio, Patricia Muñoz, Luis Alcalá, Xandra García-González, Almudena Burillo, Maria Sanjurjo, Santiago Grau, Emilio Bouza
Linezolid serum trough (Cmin) and peak levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2-8 mg/L. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid trough levels was recorded (0.1-25.2 μg/mL). Overall 65.5% of the patients had out of range trough levels, 41.1% subtherapeutic and 24.4% supratherapeutic.We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738876/enterolactone-has-stronger-effects-than-enterodiol-on-ovarian-cancer
#9
Huidi Liu, Jianrui Liu, Siwen Wang, Zheng Zeng, Ting Li, Yongfang Liu, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Sijing Hu, Shan Gao, Yingying Qi, Zhihang Shen, Hongyue Wang, Miao Yu, Tingting Gao, Randal N Johnston, Shu-Lin Liu
BACKGROUND: Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development of drug resistance. As a result, this disease has low 5-year survival rates. Estrogen receptor inhibitors were commonly used for the treatment, but only 7% to 18% of patients respond to anti-estrogen therapies. Therefore, more effective therapies to inhibit estrogen-related tumors are urgently needed. Recently, phytoestrogens, such as lignans with estrogen-like biological activities, have attracted attention for their potential effects in the prevention or treatment of estrogen-related diseases...
July 24, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28738128/possible-device-malfunction-in-a-dual-chamber-pacemaker
#10
Jared W Hornberger, Emilio Fentanes, Gregg G Gerasimon
No abstract text is available yet for this article.
July 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28737621/baroreflex-activation-therapy-a-new-approach-to-the-management-of-advanced-heart-failure-with-reduced-ejection-fraction
#11
Edoardo Gronda, Darrel Francis, Faiez Zannad, Christian Hamm, Josep Brugada, Emilio Vanoli
: Chronic heart failure is a common clinical condition characterized by persistent excessive sympathetic nervous system activation. The derangement of the sympathetic activity has relevant implications for disease progression and patient survival. Aiming to positively impact patient outcome, autonomic nervous system modulatory therapies have been developed and tested in animal and clinical studies. As a general gross assumption, direct vagal stimulation and baroreflex activation are considered equivalent. This assumption does not take into account the fact that direct cervical vagal nerve stimulation involves activation of both afferent and efferent fibers innervating not only the heart, but the entire visceral system, leading to undesired responses to and from this compartment...
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28735976/predictive-value-of-procalcitonin-for-intestinal-ischemia-and-or-necrosis-in-pediatric-patients-with-adhesive-small-bowel-obstruction-asbo
#12
Eduardo Bracho-Blanchet, Alfredo Dominguez-Muñoz, Emilio Fernandez-Portilla, Cristian Zalles-Vidal, Roberto Davila-Perez
PURPOSE: Evaluate serum procalcitonin (PCT) level as a predictor of intestinal ischemia or necrosis (IN) in patients with postoperative adhesive small bowel obstruction (ASBO). METHODS: Prospective cohort of consecutive patients with ASBO. Patients previously treated with antibiotics or septic were excluded. PCT was measured at the diagnosis of ASBO and every 24 h afterwards. MAIN OUTCOME: intestinal ischemia or necrosis (IN). RESULTS: Fifty-nine patients were included, 12 of whom were excluded; 47 patients remained in the study; male-to-female ratio = 1...
July 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28734773/epico-4-0-total-quality-in-the-management-of-invasive-candidiasis-in-critically-ill-patients-by-analysing-the-integrated-process
#13
Rafael Zaragoza, Ricard Ferrer, Pedro Llinares, Emilio Maseda, Alejandro Rodríguez, Santiago Grau, Guillermo Quindós
BACKGROUND: A high quality integrated process in the clinical setting of non-neutropenic critically ill patients at risk for invasive candidiasis is a necessary tool to improve the management of these patients. AIMS: To identify the key points on invasive candidiasis in order to develop a set of recommendations with a high level of consensus required for the creation of a total quality integrated process for the management of non-neutropenic critically ill patients at risk of invasive candidiasis...
July 19, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28733718/antimicrobial-resistance-in-the-next-30%C3%A2-years-humankind-bugs-and-drugs-a-visionary-approach
#14
REVIEW
Matteo Bassetti, Garyphallia Poulakou, Etienne Ruppe, Emilio Bouza, Sebastian J Van Hal, Adrian Brink
PURPOSE: To describe the current standards of care and major recent advances with regard to antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in this field. METHODS: Review of medical literature and expert opinion were used in the development of this review. RESULTS: There is undoubtedly a large clinical and public health burden associated with AMR in ICU, but it is challenging to quantify the associated excess morbidity and mortality...
July 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28733664/charge-injection-carriers-recombination-and-homo-energy-level-relationship-in-perovskite-solar-cells
#15
Jesús Jiménez-López, Werther Cambarau, Lydia Cabau, Emilio Palomares
We present a comparative study between a series of well-known semiconductor polymers, used in efficient organic solar cells as hole transport materials (HTM), and the state-of-the art material used as hole transport material in perovskite solar cells: the spiro-OMeTAD. The observed differences in solar cell efficiencies are studied in depth using advanced photoinduced spectroscopic techniques under working illumination conditions. We have observed that there is no correlation between the highest occupied molecular orbital (HOMO) energy levels of the organic semiconductors and the measured open-circuit voltage (VOC)...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732244/thyroglossal-duct-cysts-in-children-sonographic-features-every-radiologist-should-know-and-their-histopathological-correlation
#16
REVIEW
Emilio Inarejos Clemente, Modupe Oyewumi, Evan Probst, Bo-Yee Ngan, Mary-Louise Greer
Distinguishing between thyroglossal duct cysts (TGDC) and dermoid cysts (DC) sonographically can be challenging. We illustrate the three sonographic features in neck masses in children recently identified as being most suggestive of TGDC (septa, irregular wall and solid elements) and their corresponding histopathology. These three variables form a proposed predictive model for TGDC as a guide to surgical intervention. Pediatric radiologists should be familiar with these key imaging features, as compared with other imaging features described in TGDC also illustrated here, which are less discriminating...
July 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28729453/pi3k-and-calcium-signaling-in-cardiovascular-disease
#17
REVIEW
Alessandra Ghigo, Muriel Laffargue, Mingchuan Li, Emilio Hirsch
Receptor signaling relays on intracellular events amplified by secondary and tertiary messenger molecules. In cardiomyocytes and smooth muscle cells, cyclic AMP (cAMP) and subsequent calcium (Ca(2+)) fluxes are the best characterized receptor-regulated signaling events. However, most of receptors able to modify contractility and other intracellular responses signal through a variety of other messengers, and whether these signaling events are interconnected has long remained unclear. For example, the PI3K (phosphoinositide 3-kinase) pathway connected to the production of the lipid second messenger PIP3/PtdIns(3,4,5)P3 (phosphatidylinositol (3,4,5)-trisphosphate) is potentially involved in metabolic regulation, activation of hypertrophy, and survival pathways...
July 21, 2017: Circulation Research
https://www.readbyqxmd.com/read/28725034/common-shared-genetic-variation-behind-decreased-risk-of-breast-cancer-in-celiac-disease
#18
Emilio Ugalde-Morales, Jingmei Li, Keith Humphreys, Jonas F Ludvigsson, Haomin Yang, Per Hall, Kamila Czene
There is epidemiologic evidence showing that women with celiac disease have reduced risk of later developing breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of genetic overlap between the two diseases. Through analyses of summary statistics on densely genotyped immunogenic regions, we show a significant genetic correlation (r = -0.17, s.e. 0.05, P < 0.001) and overlap (P permuted < 0.001) between celiac disease and breast cancer. Using individual-level genotype data from a Swedish cohort, we find higher genetic susceptibility to celiac disease summarized by polygenic risk scores to be associated with lower breast cancer risk (ORper-SD, 0...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724384/deficiency-of-pi3-kinase-catalytic-isoforms-p110%C3%AE-and-p110%C3%AE-in-mice-enhances-the-il-17-g-csf-axis-and-induces-neutrophilia
#19
Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg, Sandra Beer-Hammer
BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunits p110γ and p110δ of PI3Kγ and PI3Kδ in p110γ/δ(-/-) mice leads to defective B- and T-cell homeostasis. Here we examined the role of p110γ and p110δ in the homeostasis of neutrophils by analyzing p110γ(-/-), p110δ(-/-) and p110γ/δ(-/-) mice. METHODS: Neutrophils and T cells in leukocyte suspensions from the bone marrow (BM), blood, spleen and lung were analyzed by flow cytometry...
July 19, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28723980/preliminary-results-of-topical-hepatic-hypothermia-in-a-model-of-liver-ischemia-reperfusion-injury-in-rats
#20
Emilio Elias Abdo, Estela Regina Ramos Figueira, Joel Avancini Rocha-Filho, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Telesforo Bacchella
BACKGROUND: Ischemia/reperfusion causes organ damage but it is mandatory in hepatic transplantation, trauma and other complex liver surgeries, when Pringle maneuver is applied to minimize bleeding during these procedures. It is well known that liver ischemia/reperfusion leads to microcirculatory disturbance and cellular injury. In this setting hypothermia is known to reduce oxygen demand, lowering intracellular metabolism. OBJECTIVE: To evaluate the effects of hypothermia in liver ischemia/reperfusion injury, using a new model of topic isolated liver hypothermia...
July 6, 2017: Arquivos de Gastroenterologia
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