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Psychiatry

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https://www.readbyqxmd.com/read/29334667/lithium-a-classic-drug-in-psychiatry-improves-nilotinib-mediated-antileukemic-effects
#1
Janaína Peixoto-da-Silva, Andrana K Calgarotto, Katiucha R Rocha, Caroline Palmeira-Dos-Santos, Soraya S Smaili, Gustavo J S Pereira, Fernando V Pericole, Adriana da Silva S Duarte, Sara T O Saad, Claudia Bincoletto
Although Tyrosine kinase inhibitors (TKIs) that target Bcr-Abl play a key role in Chronic Myeloid Leukemia (CML) therapy, they do not eradicate CML-initiating cells, which lead to the emergence of drug resistance. Here we used the lithium, a GSK-3 inhibitor, to attempt to potentiate the effects of nilotinib against leukemia cells. For this purpose, a K562 leukemia cell line and bone marrow cells from untreated Chronic Myeloid Leukemia (CML) patients, prior to any exposure to TKIs, were used as a model. Our results demonstrated that the combination of lithium + nilotinib (L + N) induced K562-cell death and cleaved caspase-3 when compared to lithium or nilotinib alone, accompanied by GSK-3β phosphorylation and Bcr-Abl oncoprotein levels reduction...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29332234/attitudes-of-u-s-psychiatry-residents-and-fellows-towards-mental-illness-and-its-causes-a-comparison-study-with-medical-students
#2
Catherine Chiles, Elina Stefanovics, Robert Rosenheck
Stigma towards people with mental illness remains a burden for patients and healthcare providers. This study at a large US university examined the attitudes of psychiatry residents and fellows towards mental illness and its causes, and whether their attitudes differed from the medical student attitudes previously studied utilizing the same survey method. An electronic questionnaire examining attitudes toward people with mental illness, causes of mental Illness, and treatment efficacy was used to survey the attitudes of psychiatry residents and fellows...
January 13, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29332205/microbiome-in-psychiatry-where-will-we-go
#3
EDITORIAL
Stephan Röttig, Dan Rujescu
No abstract text is available yet for this article.
January 13, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29331599/long-term-reduction-of-seclusion-and-forced-medication-on-a-hospital-wide-level-implementation-of-an-open-door-policy-over-6-years
#4
L Hochstrasser, D Fröhlich, A R Schneeberger, S Borgwardt, U E Lang, R-D Stieglitz, C G Huber
BACKGROUND: Psychiatric inpatient treatment is increasingly performed in settings with locked doors. However, locked wards have well-known disadvantages and are ethically problematic. In addition, recent data challenges the hypothesis that locked wards provide improved safety over open-door settings regarding suicide, absconding and aggression. Furthermore, there is evidence that the introduction of an open-door policy may lead to short-term reductions in involuntary measures. The aim of this study was to assess if the introduction of an open-door policy is associated with a long-term reduction of the frequency of seclusion and forced medication...
December 11, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29331192/-psychiatry-and-palliative-care-collaboration-for-the-benefit-of-the-patient
#5
REVIEW
Lionel Regard
As palliative care units continue to develop, the provision of end-of-life care for patients with a chronic mental illness needs to be addressed. Aside from the somatic comorbidities to which these patients are particularly exposed and in view of the specificity of psychiatric treatment, the forms of end-of-life support for a patient with schizophrenia are described here, based on the experience of a psychiatric unit in the Var region.
January 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29327316/-diagnosis-differential-diagnosis-and-therapy-of-substance-use-disorders-in-general-hospital-general-section
#6
REVIEW
Anton Schmick, Josef Jenewein, Sönke Böttger
Substance use disorders are becoming an increasingly significant problem in general hospitals and hence play a key role in consultation- and liaison psychiatry. Diverse psychotropic effects of various substances mimic psychiatric disorders. An alcohol intoxication can present depressive or manic symptoms, a cannabis delirium can present as a psychosis while stimulants use can suggest the diagnosis of an anxiety disorder. Obtaining dual diagnoses by identifying substance-induced and non-substance-induced psychopathologies is clinically challenging...
January 11, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29326819/association-between-bullying-and-pediatric-psychiatric-hospitalizations
#7
Hadassa Leader, Jasmine Singh, Ayesha Ghaffar, Cheryl de Silva
Objectives: Bullying is a serious public health issue. We sought to demonstrate an association between bullying victimization and hospital admissions for acute psychiatric problems. We described the demographics and types of bullying in a sample of hospitalized patients in Staten Island, NY, and compared bullying victimization scores with psychiatric versus medical admissions. Methods: Patients in grades 3-12 were recruited from the Staten Island University Hospital Inpatient Pediatrics unit and emergency department...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29325731/pharmacogenomic-testing-in-child-and-adolescent-psychiatry-an-evidence-based-review
#8
Anna M Wehry, Laura Ramsey, Shane E Dulemba, Sarah A Mossman, Jeffrey R Strawn
Significant advances have been made in the application of pharmacogenomic testing for the treatment of patients with psychiatric disorders. Over the past decade, a number of studies have evaluated the utility of pharmacogenomic testing in pediatric patients with psychiatric disorders. The evidence base for pharmacogenomic testing in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) is reviewed in this article. General pharmacogenomic principles are summarized and functional polymorphisms in P450 enzymes (and associated metabolizer phenotypes), the serotonin transporter promoter polymorphisms, serotonin 2 A receptor genes (e...
January 8, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29325478/catatonia-under-diagnosis-in-the-general-hospital
#9
Joan Roig Llesuy, Michel Medina, Kristen C Jacobson, Joseph J Cooper
Catatonia is under-diagnosed in psychiatric settings. No studies have explored the under-diagnosis of catatonia in general hospitals. The authors conducted a retrospective chart review using DSM-5 criteria to diagnose catatonia in medical inpatients between 2011 and 2013. Of 133 case subjects meeting DSM-5 criteria for catatonia retrospectively, 79 had never been diagnosed and 54 had a documented diagnosis. Multiple logistic regression revealed that psychiatry consultation significantly decreased the odds of under-diagnosis of catatonia, whereas presence of agitation, grimacing, or echolalia increased the likelihood of under-diagnosis...
January 12, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29324277/readmission-in-psychiatry-inpatients-within-a-year-of-discharge-the-role-of-symptoms-at-discharge-and-post-discharge-care-in-a-brazilian-sample
#10
Fernanda Lucia Capitanio Baeza, Neusa Sica da Rocha, Marcelo Pio de Almeida Fleck
INTRODUCTION: Readmission into inpatient psychiatric beds is a useful outcome for patients, care providers, and policymakers. This study aims to investigate the role of level of symptoms at discharge and type of post-discharge care in determining readmissions after a year before a psychiatric admission. METHODS: We performed a prospective and observational study in a general hospital psychiatric facility. Patients were assessed at admission, discharge, and one year after discharge...
December 2, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29322291/personality-pathology-in-primary-care-ongoing-needs-for-detection-and-intervention
#11
Steven K Huprich
Recent studies demonstrate that personality disorders are prevalent within outpatient psychiatry clinics, though they also are quite common in primary care settings. Studies across multiple health care settings demonstrate that those with a known PD have higher incidences of health problems, higher utilization of the health care system, and have a life expectancy 17.7 years less than that of the population in general. Despite these data, little attention has been directed toward detecting, managing, and treating patients with personality pathology in primary care settings...
January 10, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29321713/two-branches-of-the-same-tree-a-brief-history-of-turkish-neuropsychiatric-society-1914-2016
#12
Fatih Artvinli, Şahap Erkoç, Fulya Kardeş
Introduction: The aim of this article is to provide a brief history of Turkish Neuropsychiatric Society by examining its institutional background, the milestones within its history, and the major activities undertaken by the organization during the years. Methods: Firstly, the books, journals, and articles that are related to the history of psychiatry and neurology in Turkey have been reviewed and the information that can explain the history of the society has been brought together...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29321711/validity-and-reliability-of-the-turkish-version-of-dsm-5-social-anxiety-disorder-severity-scale-child-form
#13
Şermin Yalin Sapmaz, Dilek Ergin, Nesrin Şen Celasin, Duygu Karaarslan, Masum Öztürk, Handan Özek Erkuran, Ertuğrul Köroğlu, Ömer Aydemir
Introduction: This study aimed to assess the validity and reliability of the Turkish version of the Diagnostic and statistical manual of Mental Disorders. (5th ed.) (DSM-5) Social Anxiety Disorder Severity Scale- Child Form. Method: The scale was prepared by carrying out the translation and back translation of the DSM-5 Social Anxiety Disorder Severity Scale - Child Form. The study group consisted of 31 patients that had been treated in a child psychiatry unit and diagnosed with social anxiety disorder and 99 healthy volunteers that were attending middle or high school during the study period...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29321707/validity-and-reliability-of-the-turkish-version-for-dsm-5-level-2-anger-scale-child-form-for-children-aged-11-17-years-and-parent-form-for-children-aged-6-17-years
#14
Şermin Yalin Sapmaz, Handan Özek Erkuran, Nefize Yalin, Özlem Önen, Siğnem Öztekin, Canem Kavurma, Ertuğrul Köroğlu, Ömer Aydemir
Introduction: This study aimed to assess the validity and reliability of the Turkish version of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Level 2 Anger Scale. Methods: The scale was prepared by translation and back translation of DSM-5 Level 2 Anger Scale. Study groups consisted of a clinical sample of cases diagnosed with depressive disorder and treated in a child and adolescent psychiatry unit and a community sample. The study was continued with 218 children and 160 parents...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29321698/reflections-on-the-xvii-world-congress-of-psychiatry-2017
#15
EDITORIAL
Peykan Gençoğlu Gökalp
No abstract text is available yet for this article.
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29320908/psychiatric-diagnoses-and-their-influencing-factors-in-patients-complaining-of-sleep-problems-a-study-of-a-psychiatric-consultation-liaison-service
#16
Yan Chen, Enyan Yu, Zhengluan Liao, Yunfei Tan, Yaju Qiu, Junpeng Zhu, Sisi Lin, Minghao Wu
Objective This study aimed to identify misdiagnosed or undiagnosed psychiatric disorders and the factors associated with these disorders in patients with sleep problems who are referred to a consultation-liaison service. Method Records of all inpatients receiving a consultation from the Psychiatry Department between January and December 2016 were retrospectively reviewed. Psychiatric diagnoses were analyzed using descriptive statistics, and the factors associated with the risk of these disorders in patients with sleep problems were determined by multiple logistic regression analysis...
January 1, 2018: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29320866/paradigm-shift-in-psychiatry-what-may-it-involve
#17
Paul Valent
OBJECTIVE: This study aims to examine the potential nature of an ongoing paradigm shift in psychiatry that has been suggested to be occurring. CONCLUSIONS: New findings in traumatology and neuroscience do form a potential platform for a paradigm shift. Prior conflicting paradigms are suggested to be due to biases arising from mental structures themselves. A new wholist perspective is proposed, which makes sense of and incorporates previous paradigms, and coheres recent understanding of right- and left-brain functioning and biopsychosocial traumatic processes and their ramifications...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29320539/the-impact-of-electronic-consultation-on-a-canadian-tertiary-care-pediatric-specialty-referral-system-a-prospective-single-center-observational-study
#18
Lillian Lai, Clare Liddy, Erin Keely, Amir Afkham, Julia Kurzawa, Nishard Abdeen, Tobey Audcent, Matthew Bromwich, Jason Brophy, Sasha Carsen, Annick Fournier, Leigh Fraser-Roberts, Hazen Gandy, Charles Hui, Donna Johnston, Kathryn Keely, Ken Kontio, Christine Lamontagne, Nathalie Major, Michael O'Connor, Dhenuka Radhakrishnan, Joe Reisman, Marjorie Robb, Lindy Samson, Erick Sell, William Splinter, Judy van Stralen, Sunita Venkateswaran, Kimmo Murto
BACKGROUND: Champlain BASE™ (Building Access to Specialists through eConsultation) is a web-based asynchronous electronic communication service that allows primary-care- practitioners (PCPs) to submit "elective" clinical questions to a specialist. For adults, PCPs have reported improved access and timeliness to specialist advice, averted face-to-face specialist referrals in up to 40% of cases and high provider satisfaction. OBJECTIVE: To determine whether the expansion of eConsult to a pediatric setting would result in similar measures of improved healthcare system process and high provider acceptance reported in adults...
2018: PloS One
https://www.readbyqxmd.com/read/29318390/dual-training-as-clinician-scientist-in-child-and-adolescent-psychiatry-are-we-there-yet
#19
EDITORIAL
Alexis Revet, Johannes Hebebrand, Sampada Bhide, João Caseiro, Eugenia Conti, Marike Deutz, Andra Isac, Athanasios Kanellopoulos, Tuğba Kalyoncu, Katri Maasalo, Silvana Markovska-Simoska, Marija Mitkovic-Voncina, Silvia Molteni, Mariela Mosheva, Susanne Mudra, Julia Philipp, Cecil Prins-Aardema, Marina Romero Gonzalez, Antonín Šebela, Jochen Seitz, Lise Eilin Stene, Nikolina Vrljičak Davidović, Ida Wessing, Paul Klauser
No abstract text is available yet for this article.
January 9, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29317742/psychiatric-genetics-and-the-structure-of-psychopathology
#20
REVIEW
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent, external validators, such as longitudinal course and response to treatment. In the absence of an established etiology, psychiatry has struggled to validate these descriptive syndromes, and to define the boundaries between disorders and between normal and pathologic variation...
January 9, 2018: Molecular Psychiatry
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