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https://www.readbyqxmd.com/read/28735411/risk-factors-associated-with-postoperative-recurrence-and-repeat-surgery-in-japanese-patients-with-crohn-s-disease
#1
Jun Kusaka, Hisashi Shiga, Masatake Kuroha, Tomoya Kimura, Yoichi Kakuta, Katsuya Endo, Yoshitaka Kinouchi, Tooru Shimosegawa
PURPOSE: To avoid frequent surgery in patients with Crohn's disease, it is important to identify the risk factors for postoperative recurrence or repeat surgery. However, there have so far been few studies on this topic from Asian countries. In addition, the recent development of anti-tumor necrosis factor (TNF) therapy may have changed the risk factors. We aimed to identify the factors associated with postoperative recurrence and repeat surgery. METHODS: The postoperative courses of 168 patients were reviewed...
July 22, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28735355/a-systematic-review-of-dental-disease-management-in-cancer-patients
#2
Catherine H L Hong, Shijia Hu, Thijs Haverman, Monique Stokman, Joel J Napeñas, Jacolien Bos-den Braber, Erich Gerber, Margot Geuke, Emmanouil Vardas, Tuomas Waltimo, Siri Beier Jensen, Deborah P Saunders
INTRODUCTION: This systematic review aims to update on the prevalence of odontogenic-related infections and the efficacy of dental strategies in preventing dental-related complications in cancer patients since the 2010 systematic review. REVIEW METHOD: A literature search was conducted in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 2009 and 30 June 2016. Each study was assessed by 2 reviewers and the body of evidence for each intervention was assigned an evidence level...
July 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28735153/self-monitoring-systems-for-personalised-health-care-and-lifestyle-surveillance
#3
EDITORIAL
Giuseppe Coppini, Sara Colantonio
The quality of life and individual well-being are universally recognised as key factors in disease prevention. In particular, lifestyle interventions are effective tools for reducing the risk and incidence of major illnesses, such as cardiovascular diseases and metabolic disorders. On the other hand, patient role is progressively shifting from being a passive recipient of care towards being a co-producer of her/his health. In this frame, novel devices and systems able to help individuals in self-evaluation are expected to play a crucial role...
July 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28734989/hydroxyvitamin-d-assays-an-historical-perspective-from-deqas
#4
G D Carter, J Berry, R Durazo-Arvizu, E Gunter, G Jones, J Jones, H L J Makin, P Pattni, C T Sempos, P Twomey, E L Williams, S A Wise
Recent years have seen a substantial increase in demand for 25-hydroxyvitamin D (25-OHD) assays. DEQAS (the Vitamin D External Quality Assessment Scheme) has been monitoring the performance of these assays since 1989. The first DEQAS distribution was in June 1989 and results were submitted by 13 laboratories in the UK, two of which used HPLC/UV; the rest used ligand binding assays with a tritium tracer. Inter-laboratory CVs (ALTM) ranged from 29.3% (42.7 nmol/L) to 53.7% (20.0 nmol/L). Currently the scheme has participants in 56 countries using 30 methods or variants of methods...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734961/radix-puerariae-modulates-glutamatergic-synaptic-architecture-and-potentiates-functional-synaptic-plasticity-in-primary-hippocampal-neurons
#5
Mohammad Maqueshudul Haque Bhuiyan, Md Nazmul Haque, Md Mohibbullah, Yung Kyu Kim, Il Soo Moon
ETHNOPHARMACOLOGICAL RELEVANCE: Neurologic disorders are frequently characterized by synaptic pathology, including abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Therefore, to promote and/or protect synapses by the use of natural molecules capable of modulating neurodevelopmental events, such as, spinogenesis and synaptic plasticity, could offer a preventive and curative strategy for nervous disorders associated with synaptic pathology...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28734857/comorbidities-in-difficult-to-control-asthma
#6
Pieter-Paul W Hekking, Marijke Amelink, Reinier R Wener, Marcel L Bouvy, Elisabeth H Bel
BACKGROUND: Difficult-to-control asthma is associated with significant medical and financial burden. Comorbidities are known to contribute to uncontrolled asthma. Better insight into the prevalence, nature, and risk factors of comorbidities may optimize treatment strategies in patients with difficult-to-control asthma and decrease disease burden. OBJECTIVES: The objectives of this study were to assess the prevalence, number, and type of comorbidities in difficult-to-control asthma compared with not-difficult-to-control asthma, and to investigate whether specific patient characteristics are associated with particular comorbidities...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734850/progression-and-reversibility-of-stretch-induced-atrial-remodeling-characterization-and-clinical-implications
#7
REVIEW
Shivshankar Thanigaimani, Emma McLennan, Dominik Linz, Rajiv Mahajan, Thomas A Agbaedeng, Geoffrey Lee, Jonathan M Kalman, Prashanthan Sanders, Dennis H Lau
Atrial fibrillation (AF) is the most common sustained arrhythmia and across the developed nations, it contributes to increasing hospitalizations and healthcare burden. Several comorbidities and risk factors including hypertension, heart failure, obstructive sleep apnoea and obesity are known to play an important role in the initiation and perpetuation of AF and atrial stretch or dilatation may play a central mechanistic role. The impact of atrial stretch in the development of AF can vary dependent on the underlying disease...
July 19, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28734731/postnatal-corticosteroids-to-prevent-or-treat-bronchopulmonary-dysplasia-who-might-benefit
#8
REVIEW
Lex W Doyle, Jeanie L Y Cheong
Newborn infants born very preterm are at high risk of developing bronchopulmonary dysplasia, which is associated with not only mortality but also adverse long-term neurological and respiratory outcomes in survivors. Postnatal corticosteroids might reduce the risk of developing bronchopulmonary dysplasia, or reduce its severity. However, it is important to minimize exposure to the potentially harmful effects of corticosteroids, particularly on the developing brain. Systemic corticosteroids started after the first week of life have shown the most benefit in infants at highest risk of developing bronchopulmonary dysplasia, whereas inhaled corticosteroids have little effect in children with established lung disease...
July 19, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28734649/maxillary-and-mandibular-non-hodgkin-lymphoma-with-concurrent-periapical-endodontic-disease-diagnosis-and-management
#9
Jennifer M Dolan, Anna DeGraft-Johnson, Neville McDonald, Brent B Ward, Tycel J Phillips, Stephanie M Munz
Extranodal non-Hodgkin lymphoma (NHL) in the oral region can present similarly to diseases of odontogenic origin. The objective of this report was to describe a rare case of maxillary and mandibular NHL that presented similarly to and concurrently with lesions of odontogenic origin.A unique case of extranodal NHL, which presented at the apices of maxillary and mandibular teeth in conjunction with lesions of odontogenic origin in a 68-year-old white man, is described. The patient sought care because of a lesion in the right maxillary paranasal region that caused him paresthesia...
July 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28734553/dietary-inflammatory-index-and-liver-status-in-subjects-with-different-adiposity-levels-within-the-predimed-trial
#10
Irene Cantero, Itziar Abete, Nancy Babio, Fernando Arós, Dolores Corella, Ramón Estruch, Montse Fitó, James R Hebert, M Ángel Martínez-González, Xavier Pintó, M Puy Portillo, Miguel Ruiz-Canela, Nitin Shivappa, Julia Wärnberg, Enrique Gómez-Gracia, J Antoni Tur, Jordi Salas-Salvadó, M Angeles Zulet, J Alfredo Martínez
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted...
July 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28734547/management-of-hemostatic-disorders-in-patients-with-advanced-liver-disease-admitted-to-an-intensive-care-unit
#11
REVIEW
Ton Lisman, William Bernal
Patients with liver diseases frequently acquire complex changes in their hemostatic system. Traditionally, bleeding complications in patients with liver disease were ascribed to these hemostatic changes, and liver diseases were considered as an acquired bleeding disorder. Nowadays, it is increasingly acknowledged that patients with liver diseases are in "hemostatic rebalance" due to a commensurate decline in pro- and anticoagulant drivers. Indeed, both thrombosis and bleeding may complicate liver disease. Such complications may be particularly worrisome in critically ill patients with liver disease...
June 23, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28734528/exploring-risk-patterns-for-incident-ischemic-stroke-during-more-than-a-decade-of-follow-up-a-survival-tree-analysis
#12
Donna Parizadeh, Azra Ramezankhani, Amir Abbas Momenan, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND AND PURPOSE: The burden of stroke is increasing in low to middle income countries. Identifying risk patterns for ischemic stroke (IS) can help develop individualized preventive measures for at risk populations. METHODS: The study population included 3088 Iranian subjects (1426 men) aged ≥50 years, free of cardiovascular diseases at baseline. The risk factors for ischemic stroke were identified by multivariate Cox analysis. A survival tree model was used to explore interactions between risk factors...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28734517/tuberculosis-in-children
#13
REVIEW
Tania A Thomas
Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen. The World Health Organization estimates that annually 1 million children have tuberculosis (TB) disease and many more harbor a latent form. Accurate estimates are hindered by under-recognition and challenges in diagnosis. To date, an accurate diagnostic test to confirm TB in children does not exist. Treatment is lengthy but outcomes are generally favorable with timely initiation. With the End TB Strategy, there is an urgent need for improved diagnostics and treatment to prevent the unnecessary morbidity and mortality from TB in children...
August 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28734136/the-good-and-bad-of-targeting-cancer-associated-extracellular-matrix
#14
REVIEW
Sabina Sangaletti, Claudia Chiodoni, Claudio Tripodo, Mario P Colombo
The maintenance of tissue homeostasis requires extracellular matrix (ECM) remodeling. Immune cells actively participate in regenerating damaged tissues contributing to ECM deposition and shaping. Dysregulated ECM deposition characterizes fibrotic diseases and cancer stromatogenesis, where a chronic inflammatory state sustains the ECM increase. In cancer, the ECM fosters several steps of tumor progression, providing pro-survival and proliferative signals, promoting tumor cell dissemination via collagen fibers or acting as a barrier to impede drug diffusion...
July 19, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28734089/dementia-risk-and-prevention-by-targeting-modifiable-vascular-risk-factors
#15
REVIEW
Sana Tariq, Philip A Barber
The incidence of dementia is expected to double in the next 20 years and will contribute to heavy social and economic burden. Dementia is caused by neuronal loss that leads to brain atrophy years before symptoms manifest. Currently, no cure exists and extensive efforts are being made to mitigate cognitive impairment in late life in order to reduce the burden on patients, caregivers, and society. The most common type of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) often co-exists in the brain and shares common, modifiable risk factors, which are targeted in numerous secondary prevention trials...
July 22, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28734036/-epicatechin-regulates-blood-lipids-and-attenuates-hepatic-steatosis-in-rats-fed-high-fat-diet-%C3%A2
#16
Hui Cheng, Na Xu, Wenxia Zhao, Jingjing Su, Mengru Liang, Zhongwen Xie, Xianli Wu, Qinglin Li
SCOPE: (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated. METHODS AND RESULTS: A hyperlipidemic rat model was induced by high-fat, high-cholesterol diet. EC was then administrated to the animals by gavage at doses of 10 mg/kg, 20 mg/kg, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28733997/natural-history-of-periodontitis-disease-progression-and-tooth-loss-over-40-years
#17
C A Ramseier, Å Ånerud, M Dulac, M Lulic, M P Cullinan, G J Seymour, M J Faddy, W Büergin, M Schätzle, N P Lang
OBJECTIVES: To assess long-term attachment and periodontitis-related tooth loss (PTL) in untreated periodontal disease over 40 years. MATERIAL AND METHODS: Data originated from the natural history of periodontitis study in Sri Lankan tea labourers first examined in 1970. In 2010, 75 subjects (15.6%) of the original cohort were re-examined. RESULTS: PTL over 40 years varied between 0 and 28 teeth (mean 13.1). Four subjects presented with no PTL while 12 were edentulous...
July 22, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28733944/the-gastric-and-intestinal-microbiome-role-of-proton-pump-inhibitors
#18
REVIEW
Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs, Joseph R Pisegna
PURPOSE OF REVIEW: The discovery of Helicobacter pylori and other organisms colonizing the stomach and the intestines has shed some light on the importance of microbiome in maintaining overall health and developing pathological conditions when alterations in biodiversity are present. The gastric acidity plays a crucial role in filtering out bacteria and preventing development of enteric infections. In this article, we discuss the physiology of gastric acid secretion and bacterial contribution to the composition of gastric and intestinal barriers and review the current literature on the role of proton pump inhibitors (PPIs) in the microbial biodiversity of the gastrointestinal tract...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28733914/molecular-and-functional-analysis-of-monoclonal-antibodies-in-support-of-biologics-development
#19
REVIEW
Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia, Qinjian Zhao
Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in the treatment or prevention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi-domain mAbs are far more complex than small molecule drugs with intrinsic heterogeneities. The critical quality attributes of a given mAb, including structure, post-translational modifications, and functions at biomolecular and cellular levels, need to be defined and profiled in details during the developmental phases of a biologics...
July 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28733905/glp-1-glucagon-receptor-co-agonism-for-treatment-of-obesity
#20
REVIEW
Miguel A Sánchez-Garrido, Sara J Brandt, Christoffer Clemmensen, Timo D Müller, Richard D DiMarchi, Matthias H Tschöp
Over a relatively short period, obesity and type 2 diabetes have come to represent a large medical and economic burden to global societies. The epidemic rise in the prevalence of obesity has metabolic consequences and is paralleled by an increased occurrence of other diseases, such as diabetes, cancer and cardiovascular complications. Together, obesity and type 2 diabetes constitute one of the more preventable causes of premature death and the identification of novel, safe and effective anti-obesity drugs is of utmost importance...
July 21, 2017: Diabetologia
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