Alba Camacho-Cardenosa, Antonio Clavero-Jimeno, Juan J Martin-Olmedo, Francisco Amaro-Gahete, Rocío Cupeiro, María Trinidad González Cejudo, Patricia Virginia García Pérez, Carlos Hernández-Martínez, Raquel Sevilla-Lorente, Alejandro De-la-O, Alejandro López-Vázquez, Marcos Molina-Fernandez, Almudena Carneiro-Barrera, Federico Garcia, Alba Rodríguez-Nogales, Julio Juan Gálvez Peralta, Rafael Cabeza, José L Martín-Rodríguez, Araceli Muñoz-Garach, Manuel Muñoz-Torres, Idoia Labayen, Jonatan R Ruiz
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. Implementing strategies based on an intermittent fasting approach and supervised exercise may mitigate the risks. This study aims to investigate the effects of a 12-week time-restricted eating (TRE) intervention combined with a supervised exercise intervention, compared with TRE or supervised exercise alone and with a usual-care control group, on hepatic fat (primary outcome) and cardiometabolic health (secondary outcomes) in adults with obesity...
January 24, 2024: BMJ Open