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https://www.readbyqxmd.com/read/28814034/automated-assessment-of-symptom-severity-changes-during-deep-brain-stimulation-dbs-therapy-for-parkinson-s-disease
#1
Paolo Angeles, Yen Tai, Nicola Pavese, Samuel Wilson, Ravi Vaidyanathan
Deep brain stimulation (DBS) is currently being used as a treatment for symptoms of Parkinson's disease (PD). Tracking symptom severity progression and deciding the optimal stimulation parameters for people with PD is extremely difficult. This study presents a sensor system that can quantify the three cardinal motor symptoms of PD - rigidity, bradykinesia and tremor. The first phase of this study assesses whether data recorded from the system during physical examinations can be used to correlate to clinician's severity score using supervised machine learning (ML) models...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814020/piecewise-and-unified-phase-variables-in-the-control-of-a-powered-prosthetic-leg
#2
Dario J Villarreal, David Quintero, Robert D Gregg
Many control methods have been proposed for powered prosthetic legs, ranging from finite state machines that switch between discrete phases of gait to unified controllers that have a continuous sense of phase. In particular, recent work has shown that a mechanical phase variable can parameterize the entire gait cycle for controlling a prosthetic leg during steady rhythmic locomotion. However, the unified approach does not provide voluntary control over non-rhythmic motions like stepping forward and back. In this paper we present a phasing algorithm that uses the amputee's hip angle to control both rhythmic and non-rhythmic motion through two modes: 1) a piecewise (PW) function that provides users voluntary control over stance and swing in a piecewise manner, and 2) a unified function that continuously synchronizes the motion of the prosthetic leg with the amputee user at different walking speeds...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813999/upper-limb-prosthetic-control-using-wearable-multichannel-mechanomyography
#3
Samuel Wilson, Ravi Vaidyanathan
In this paper we introduce a robust multi-channel wearable sensor system for capturing user intent to control robotic hands. The interface is based on a fusion of inertial measurement and mechanomyography (MMG), which measures the vibrations of muscle fibres during motion. MMG is immune to issues such as sweat, skin impedance, and the need for a reference signal that is common to electromyography (EMG). The main contributions of this work are: 1) the hardware design of a fused inertial and MMG measurement system that can be worn on the arm, 2) a unified algorithm for detection, segmentation, and classification of muscle movement corresponding to hand gestures, and 3) experiments demonstrating the real-time control of a commercial prosthetic hand (Bebionic Version 2)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813078/quality-of-life-in-parkinson-s-disease-patients-progression-markers-of-mild-to-moderate-stages
#4
Raissa Carla Moreira, Marise Bueno Zonta, Ana Paula Serra de Araújo, Vera Lúcia Israel, Hélio A G Teive
Objective: To investigate which factors are associated with the quality of life decline in Parkinson's disease patients from mild to moderate stages. Methods: The Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire-39 were used to evaluate clinical/functional data and the quality of life. Results: The markers of clinical/functional worsening were drooling (p < 0.004), need for assistance with hygiene (p = 0.02), greater freezing frequency (p = 0...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28812961/community-managed-services-for-persons-with-intellectual-disability-andhra-pradesh-experience
#5
Jayanthi Narayan, Raja Pratapkumar, Sudhakara P Reddy
In resource poor settings innovative and bottom-up approaches are required to provide services to people with with disabilities. In this context, the present paper explains a community-based model of manpower development and coordination of services for people with intellectual disabilities in unified state of Andhra Pradesh in India. Women with disabilities from the village were identified, and those willing to be trained to work as community resource persons (CRPs) were selected and given hands-on training in a phased manner...
September 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28812691/a-macroecological-theory-of-microbial-biodiversity
#6
William R Shoemaker, Kenneth J Locey, Jay T Lennon
Microorganisms are the most abundant, diverse and functionally important organisms on Earth. Over the past decade, microbial ecologists have produced the largest ever community datasets. However, these data are rarely used to uncover law-like patterns of commonness and rarity, test theories of biodiversity, or explore unifying explanations for the structure of microbial communities. Using a global scale compilation of >20,000 samples from environmental, engineered and host-related ecosystems, we test the power of competing theories to predict distributions of microbial abundance and diversity-abundance scaling laws...
April 3, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812404/effects-of-a-low-resistance-interval-bicycling-intervention-in-parkinson-s-disease
#7
Mehmet Uygur, Maria Bellumori, Christopher A Knight
Previous studies have shown that people with Parkinson's disease (PD) benefit from a variety of exercise modalities with respect to symptom management and function. Among the possible exercise modalities, speedwork has been identified as a promising strategy, with direct implications for the rate and amplitude of nervous system involvement. Considering that previous speed-based exercise for PD has often been equipment, personnel and/or facility dependent, and often time intensive, our purpose was to develop a population-specific exercise program that could be self-administered with equipment that is readily found in fitness centers or perhaps the home...
August 16, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28810946/safety-and-efficacy-of-rotigotine-for-treating-parkinson-s-disease-a-meta-analysis-of-randomised-controlled-trials
#8
Fei Chen, Lingjing Jin, Zhiyu Nie
We aimed to comprehensively analyse the safety and efficiency of rotigotine for treating Parkinson's disease (PD). We conducted systematic literature searches of Cochrane library, PubMed and Embase databases up to April 2016, with 'Rotigotine', 'Parkinson Disease ' and 'Parkinson's disease' as key searching terms. Outcomes, including Unified Parkinson's Disease Rating Scale (UPDRS) Part III and Part II scores, 'off' time, adverse events (AEs), serious AEs and discontinuation because of AEs, were compared between rotigotine and placebo groups under a fixed or random effect model...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28810329/-distribution-and-drug-resistance-of-pathogens-at-hematology-department-of-jiangsu-province-from-2014-to-2015-results-from-a-multicenter-retrospective-study
#9
Y K Wan, W Sang, B Chen, Y G Yang, L Q Zhang, A N Sun, Y J Liu, Y Xu, Y P Cai, C B Wang, Y F Shen, Y W Jiang, X Y Zhang, W Xu, M Hong, T Chen, R R Xu, F Li, Y L Xu, Y Xue, Y L Lu, Z M He, W M Dong, Z Chen, M H Ji, Y Y Yang, L J Zhai, Y Zhao, G Q Wu, J H Ding, J Cheng, W B Cai, Y M Sun, J Ouyang
Objective: To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment. Methods: Pathogens were from hematology department of 26 tertiary hospitals in Jiangsu Province from 2014 to 2015. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or agar dilution method. Collection of drug susceptibility results and corresponding patient data were analyzed...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28809923/generalized-structural-equations-improve-sexual-selection-analyses
#10
Sonia Lombardi, Giacomo Santini, Giovanni Maria Marchetti, Stefano Focardi
Sexual selection is an intense evolutionary force, which operates through competition for the access to breeding resources. There are many cases where male copulatory success is highly asymmetric, and few males are able to sire most females. Two main hypotheses were proposed to explain this asymmetry: "female choice" and "male dominance". The literature reports contrasting results. This variability may reflect actual differences among studied populations, but it may also be generated by methodological differences and statistical shortcomings in data analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28809697/geometric-and-photometric-consistency-in-a-mixed-video-and-galvanoscopic-scanning-laser-projection-mapping-system
#11
Petar Pjanic, Simon Willi, Anselm Grundhofer
We present a geometric calibration method to accurately register a galvanoscopic scanning laser projection system (GLP) based on 2D vector input data onto an arbitrarily complex 3D-shaped projection surface. This method allows for accurate merging of 3D vertex data displayed on the laser projector with geometrically calibrated standard rasterization-based video projectors that are registered to the same geometry. Because laser projectors send out a laser light beam via galvanoscopic mirrors, a standard pinhole model calibration procedure that is normally used for pixel raster displays projecting structured light patterns, such as Gray codes, cannot be carried out directly with sufficient accuracy as the rays do not converge into a single point...
August 10, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28809668/tractography-based-score-for-learning-effective-connectivity-from-multimodal-imaging-data-using-dynamic-bayesian-networks
#12
Shilpa Dang, Santanu Chaudhury, Brejesh Lall, Prasun K Roy
OBJECTIVE: Effective connectivity (EC) is the methodology for determining functional-integration among the functionally-active segregated regions of the brain. By definition [1] EC is "the causal influence exerted by one neuronal group on another" which is constrained by anatomical connectivity (AC) (axonal connections). AC is necessary for EC but does not fully determine it, because synaptic communication occurs dynamically in a context-dependent fashion. Although there is a vast emerging evidence of structure-function relationship using multimodal imaging studies, till date only a few studies have done joint modelling of the two modalities: functional MRI (fMRI) and Diffusion Tensor Imaging (DTI)...
August 10, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28808065/the-punctilious-rna-polymerase-ii-core-promoter
#13
REVIEW
Long Vo Ngoc, Yuan-Liang Wang, George A Kassavetis, James T Kadonaga
The signals that direct the initiation of transcription ultimately converge at the core promoter, which is the gateway to transcription. Here we provide an overview of the RNA polymerase II core promoter in bilateria (bilaterally symmetric animals). The core promoter is diverse in terms of its composition and function yet is also punctilious, as it acts with strict rules and precision. We additionally describe an expanded view of the core promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcription factors, chromatin signals, and DNA structure...
July 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28807728/vestibulo-ocular-reflex-abnormality-in-parkinson-s-disease-detected-by-video-head-impulse-test
#14
Wen Lv, Qiongfeng Guan, Xingyue Hu, Jiaqi Chen, Hong Jiang, Lisan Zhang, Weinv Fan
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disease characterized by dopaminergic neuronal loss. The underlying cause of PD is unknown. OBJECTIVE: To assess the clinical relevance of vestibular-ocular reflex (VOR) gain in patients with PD, especially those in the early stages. METHODS: Sixty-three PD patients and 56 control healthy individuals were enrolled in this study between Mar 2015 and Aug 2015. VOR gains were determined by video head impulse test (vHIT) device...
August 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28805190/driving-force-of-the-orbital-relevant-electronic-nematicity-in-fe-based-superconductors
#15
Tao Li, Yuehua Su
The electronic nematic responses in Fe-based superconductors have been observed ubiquitously in various experimental probes. One novel nematic character is the d-wave {\it bond} orbital-relevant nematic charge order which was firstly proposed by symmetry analysis and then conformed by angle-resolved photoemission spectroscopy. In this paper, we present a mechanism that the driving force of the orbital-relevant nematic charge order is the reduction of the large Hubbard energy in the particle-hole charge channel by virtual hopping processes...
August 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28804806/how-biological-background-assumptions-influence-scientific-risk-evaluation-of-stacked-genetically-modified-plants-an-analysis-of-research-hypotheses-and-argumentations
#16
Elena Rocca, Fredrik Andersen
Scientific risk evaluations are constructed by specific evidence, value judgements and biological background assumptions. The latter are the framework-setting suppositions we apply in order to understand some new phenomenon. That background assumptions co-determine choice of methodology, data interpretation, and choice of relevant evidence is an uncontroversial claim in modern basic science. Furthermore, it is commonly accepted that, unless explicated, disagreements in background assumptions can lead to misunderstanding as well as miscommunication...
August 14, 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28803960/evaluating-impacts-of-different-longitudinal-driver-assistance-systems-on-reducing-multi-vehicle-rear-end-crashes-during-small-scale-inclement-weather
#17
Ye Li, Lu Xing, Wei Wang, Hao Wang, Changyin Dong, Shanwen Liu
Multi-vehicle rear-end (MVRE) crashes during small-scale inclement (SSI) weather cause high fatality rates on freeways, which cannot be solved by traditional speed limit strategies. This study aimed to reduce MVRE crash risks during SSI weather using different longitudinal driver assistance systems (LDAS). The impact factors on MVRE crashes during SSI weather were firstly analyzed. Then, four LDAS, including Forward collision warning (FCW), Autonomous emergency braking (AEB), Adaptive cruise control (ACC) and Cooperative ACC (CACC), were modeled based on a unified platform, the Intelligent Driver Model (IDM)...
August 9, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28803910/a-measure-to-quantify-the-degree-of-cooperativity-in-overall-titration-curves
#18
Johannes W R Martini
In the framework of the grand canonical ensemble, different definitions of cooperativity commonly used in the context of ligand binding are not equivalent. A unifying definition is the existence of non-real roots of the binding polynomial. Using this qualitative criterion, an open question is how to quantify the degree of cooperativity. In this work, we introduce a theoretical measure to quantify the degree of cooperativity of a titriation curve. Its definition is based on a minimal energy approach mapping a given binding polynomial to the minimal interaction energy which is required to generate it...
August 10, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28802934/psychosis-in-parkinson-s-disease
#19
Dominic H Ffytche, Dag Aarsland
Although illusions, hallucinations and delusions did not play a prominent role in James Parkinson's original clinical descriptions, the longitudinal view of disease progression he advocated has important lessons for the study of such symptoms today. A focus on longitudinal progression rather than individual symptoms led to the concept of PD psychosis-a spectrum of positive symptoms in Parkinson's disease. The publication of criteria for PD psychosis in 2007 helped unify the disparate set of symptoms, raising their profile and resulting in a rapid expansion of literature focussing on clinical aspects, mechanisms, and treatment...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802828/photolyase-dynamics-and-electron-transfer-mechanisms-of-dna-repair
#20
REVIEW
Meng Zhang, Lijuan Wang, Dongping Zhong
Photolyase, a flavoenzyme containing flavin adenine dinucleotide (FAD) molecule as a catalytic cofactor, repairs UV-induced DNA damage of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproduct using blue light. The FAD cofactor, conserved in the whole protein superfamily of photolyase/cryptochromes, adopts a unique folded configuration at the active site that plays a critical functional role in DNA repair. Here, we review our comprehensive characterization of the dynamics of flavin cofactor and its repair photocycles by different classes of photolyases on the most fundamental level...
August 9, 2017: Archives of Biochemistry and Biophysics
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