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https://www.readbyqxmd.com/read/28926957/combining-a-multi-agent-system-and-communication-middleware-for-smart-home-control-a-universal-control-platform-architecture
#1
Song Zheng, Qi Zhang, Rong Zheng, Bi-Qin Huang, Yi-Lin Song, Xin-Chu Chen
In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome) based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926206/asymmetric-total-syntheses-of-communesin-f-and-a-putative-member-of-the-communesin-family
#2
David Yu-Kai Chen
Here we report asymmetric total syntheses of communesin F and a putative member of the communesin family of bis-aminal alkaloid natural products. The successful strategy featured the invention of an asymmetric organocatalytic reaction to unify two oxindole subunits, a Ti(OiPr)4-mediated dehydrative skeletal rearrangement, and a late-stage Pd(OAc)2-catalyzed directed CH-alkenylation reaction. Collectively, the synthetic technologies disclosed herein enabled the preparation of a late-stage polycyclic intermediate catered for the synthesis of both naturally occurring and designed communesins...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28925352/bmps-direct-sensory-interneuron-identity-in-the-developing-spinal-cord-using-signal-specific-not-morphogenic-activities
#3
Madeline G Andrews, Lorenzo M Del Castillo, Eliana Ochoa-Bolton, Ken Yamauchi, Jan Smogorzewski, Samantha J Butler
The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis. In the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs). Previous studies suggested that the BMPs act as concentration-dependent morphogens to direct IN identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord. However, it remains unresolved how multiple BMPs would cooperate to establish a unified morphogen gradient...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28924009/site-specific-regulation-of-p2x7-receptor-function-in-microglia-gates-morphine-analgesic-tolerance
#4
Heather Leduc-Pessah, Nicholas L Weilinger, Churmy Y Fan, Nicole E Burma, Roger J Thompson, Tuan Trang
Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating microglia in the spinal cord using a saporin-conjugated antibody to Mac1, we demonstrate a causal role for microglia in the development, but not maintenance, of morphine tolerance in male rats. Increased P2X7 receptor (P2X7R) activity is a cardinal feature of microglial activation, and in this study we found that morphine potentiates P2X7R-mediated Ca(2+) responses in resident spinal microglia acutely isolated from morphine tolerant rats...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923482/the-optimal-regulation-mode-of-bcl-2-apoptotic-switch-revealed-by-bistability-analysis
#5
Zhiyong Yin, Hong Qi, Lili Liu, Zhen Jin
In most cell types, apoptosis occurs by the mitochondrial outer membrane permeability (MOMP)-mediated pathway, which is controlled by Bcl-2 family proteins (often referred to as Bcl-2 apoptotic switch). These proteins, which display a range of bioactivities, can be divided into four types: effectors, inhibitors, activators and sensitizers. Although the complex interactions among Bcl-2 family members have been studied intensively, a unifying hypothesis for the mechanism they use to regulate MOMP remains elusive...
September 15, 2017: Bio Systems
https://www.readbyqxmd.com/read/28923430/mapping-the-brain-of-the-chicken-gallus-gallus-with-emphasis-on-the-septal-hypothalamic-region
#6
REVIEW
Wayne J Kuenzel
There has been remarkable progress in discoveries made in the avian brain, particularly over the past two decades. This review first highlights some of the discoveries made in the forebrain and credits the Avian Brain Nomenclature Forum, responsible for changing many of the terms found in the cerebrum and for stimulating collaborative research thereafter. The Forum facilitated communication among comparative neurobiologists by eliminating confusing and inaccurate names. The result over the past 15 years has been a standardized use of avian forebrain terms...
September 15, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28923293/two-polysomnographic-features-of-rem-sleep-behavior-disorder-clinical-variations-insight-for-parkinson-s-disease
#7
Yun Shen, Yong-Ping Dai, Yi Wang, Jie Li, Kang-Ping Xiong, Cheng-Jie Mao, Jun-Ying Huang, Wei-Feng Luo, Chun-Feng Liu
INTRODUCTION: Loss of REM sleep muscle atonia (RWA) and dream-enactment behavior (DEB) are two associated features of REM sleep behavior disorder (RBD), which is frequently associated with Parkinson's disease (PD). Few studies have examined both DEB and RWA simultaneously in patients with PD. This study aimed to evaluate relationships between RWA, DEB and clinical characteristics of PD. METHODS: We conducted overnight polysomnography in 145 patients with PD. DEB (motor behaviors and/or vocalizations during REM) and increased RWA (IRWA; tonic and phasic chin EMG density ≥ 30% and ≥15%, respectively) were identified...
September 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28922399/probing-eukaryotic-cell-mechanics-via-mesoscopic-simulations
#8
Kirill Lykov, Yasaman Nematbakhsh, Menglin Shang, Chwee Teck Lim, Igor V Pivkin
Cell mechanics has proven to be important in many biological processes. Although there is a number of experimental techniques which allow us to study mechanical properties of cell, there is still a lack of understanding of the role each sub-cellular components plays during cell deformations. We present a new mesoscopic particle-based eukaryotic cell model which explicitly describes cell membrane, nucleus and cytoskeleton. We employ Dissipative Particle Dynamics (DPD) method that provides us with the unified framework for modeling of a cell and its interactions in the flow...
September 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28922312/maximum-step-length-test-performance-in-people-with-parkinson-disease-a-cross-sectional-study
#9
Ryan P Duncan, Marie E McNeely, Gammon M Earhart
BACKGROUND AND PURPOSE: The Maximum Step Length Test (MSLT), a measure of one's capacity to produce a large step, has been studied in older adults, but not in people with Parkinson disease (PD). We characterized performance and construct validity of the MSLT in PD. METHODS: Forty participants (mean age: 65.12 ± 8.20 years; 45% female) with idiopathic PD completed the MSLT while "OFF" and "ON" anti-PD medication. Construct validity was investigated by examining relationships between MSLT and measures of motor performance...
October 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28922168/evaluation-of-rna-blood-biomarkers-in-individuals-at-risk-of-parkinson-s-disease
#10
Jose A Santiago, Judith A Potashkin
BACKGROUND: Substantial progress has been made in the discovery of blood biomarkers for Parkinson's disease (PD), a progressive neurodegenerative disease that affects more than 4 million worldwide. Olfactory dysfunction and dopamine deficits usually precede motor symptoms years before the onset of PD. A readily accessible biomarker useful for identifying patients at risk of PD is expected to accelerate clinical trials. OBJECTIVE: To evaluate previously identified PD blood RNA biomarkers in a cohort of asymptomatic individuals at risk of PD...
September 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28922127/jointly-learning-structured-analysis-discriminative-dictionary-and-analysis-multiclass-classifier
#11
Zhao Zhang, Weiming Jiang, Jie Qin, Li Zhang, Fanzhang Li, Min Zhang, Shuicheng Yan
In this paper, we propose an analysis mechanism-based structured analysis discriminative dictionary learning (ADDL) framework. The ADDL seamlessly integrates ADDL, analysis representation, and analysis classifier training into a unified model. The applied analysis mechanism can make sure that the learned dictionaries, representations, and linear classifiers over different classes are independent and discriminating as much as possible. The dictionary is obtained by minimizing a reconstruction error and an analytical incoherence promoting term that encourages the subdictionaries associated with different classes to be independent...
September 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28921829/vegetation-demographics-in-earth-system-models-a-review-of-progress-and-priorities
#12
Rosie A Fisher, Charles D Koven, William R L Anderegg, Bradley O Christoffersen, Michael C Dietze, Caroline Farrior, Jennifer A Holm, George Hurtt, Ryan G Knox, Peter J Lawrence, Jeremy W Lichststein, Marcos Longo, Ashley M Matheny, David Medvigy, Helene C Muller-Landau, Thomas L Powell, Shawn P Serbin, Hisashi Sato, Jacquelyn Shuman, Benjamin Smith, Anna T Trugman, Toni Viskari, Hans Verbeeck, Ensheng Weng, Chonggang Xu, Xiangtao Xu, Tao Zhang, Paul Moorcroft
Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models (ESMs). These developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that require empirical constraints. Here, we review the developments that permit the representation of plant demographics in ESMs, and identify issues raised by these developments that highlight important gaps in ecological understanding...
September 18, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28921390/the-state-of-men-s-health-services-in-the-veterans-health-administration
#13
REVIEW
Michael Fenstermaker, Sujay Paknikar, Amarnath Rambhatla, Dana A Ohl, Ted A Skolarus, James M Dupree
PURPOSE OF REVIEW: For many diseases that place a large burden on our health care system, men often have worse health outcomes than women. As the largest single provider of health care to men in the USA, the Veterans Health Administration (VA) has the potential to serve as leader in the delivery of improved men's health care to address these disparities. RECENT FINDINGS: The VA system has made recent strides in improving benefits for aspects of men's health that are traditionally poorly covered, such as treatment for male factor infertility...
September 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28920983/unified-elucidation-of-the-entropy-driven-and-opposed-hydrophobic-effects
#14
Masahiro Kinoshita, Tomohiko Hayashi
The association of nonpolar solutes is generally believed to be entropy driven, which has been shown to be true for the contact of small molecules, ellipsoids, and plates. However, it has been reported with surprise that a model cavity-ligand binding is entropy opposed. How can these apparently conflicting behaviors be elucidated? Here, we calculate the potential of mean force between hard-sphere solutes with various diameters in water and its entropic and enthalpic components using a statistical-mechanical theory for molecular liquids...
September 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28920915/revisiting-local-structural-changes-in-geo-sub-2-sub-glass-at-high-pressure
#15
Juncai Dong, HuRong Yao, Zhiying Guo, Quanjie Jia, Yan Wang, Pengfei An, Yu Gong, Yaxiang Liang, Dongliang Chen
Despite the great importance in fundamental and industrial fields, understanding structural changes for pressure-induced polyamorphism in network-forming glasses remains a formidable challenge. Here, we revisited the local structural transformations in GeO2 glass up to 54 GPa using x-ray absorption fine structure (XAFS) spectroscopy via a combination diamond anvil cell and polycapillary half-lens. Three polyamorphic transitions can be clearly identified by XAFS structure refinement. First, a progressive increase of the nearest Ge-O distance and bond disorder to a maximum at ~5-16 GPa, in the same pressure region of previously observed tetrahedral-octahedral transformation...
September 18, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28920696/regio-and-stereospecific-construction-of-3a-1h-indol-3-yl-pyrrolidinoindolines-and-application-to-the-formal-syntheses-of-gliocladins-b-and-c
#16
Honghui Lei, Lushun Wang, Zhengshuang Xu, Tao Ye
A one-pot regio- and stereospecific strategy for the construction of 3a-(3-indolyl)-hexahydropyrrolo[2,3-b]indoles based on the condensation of an indole and an in situ generated cyclopropylazetoindoline has been developed. This unified strategy works with a variety of substituted indoles to produce 3a-(3-indolyl)hexahydropyrrolo[2,3-b]indole products in high yields. The utility of this transformation was highlighted in the formal total syntheses of gliocladins B and C.
September 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/28920562/comparison-of-general-and-local-anesthesia-for-deep-brain-stimulator-insertion-a-systematic-review
#17
Veena Sheshadri, Nathan C Rowland, Jigesh Mehta, Marina Englesakis, Pirjo Manninen, Lashmi Venkatraghavan
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) has become a standard treatment for many patients with Parkinson's disease (PD). The reported clinical outcome measures for procedures done under general anesthesia (GA) compared to traditional local anesthetic (LA) technique are quite heterogeneous and difficult to compare. The aim of this systematic review and metaanalysis was to determine whether the clinical outcome after STN-DBS insertion under GA is comparable to that under LA in patients with Parkinson's disease...
September 18, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28920067/a-history-of-dystonia-ancient-to-modern
#18
REVIEW
Rachel E Newby, Deborah E Thorpe, Peter A Kempster, Jane E Alty
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to identify in historical documents. Torticollis is an exception, although there is difficulty distinguishing dystonic torticollis from congenital muscular torticollis. There are, nevertheless, possible representations of dystonia in literature and visual art from the pre-modern world...
July 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/28920018/neonatal-sex-assignment-in-disorders-of-sex-development-a-philosophical-introspection
#19
REVIEW
V Raveenthiran
Management of ambiguous genitalia is highly controversial. This condition was known previously as intersex and presently as disorders of sex development (DSD). There is no consensus regarding the choice, timing and method of sex assignment in neonates with DSD. Consensus conferences could not unify the views of various stakeholders and third parties. This article philosophically examines the nature and origin of such controversies. Misconception, bias and conflicting priorities are identified as the three cardinal sources of controversies...
July 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28919877/analysis-of-correlation-between-an-accelerometer-based-algorithm-for-detecting-parkinsonian-gait-and-updrs-subscales
#20
Alejandro Rodríguez-Molinero, Albert Samà, Carlos Pérez-López, Daniel Rodríguez-Martín, Sheila Alcaine, Berta Mestre, Paola Quispe, Benedetta Giuliani, Gabriel Vainstein, Patrick Browne, Dean Sweeney, J Manuel Moreno Arostegui, Àngels Bayes, Hadas Lewy, Alberto Costa, Roberta Annicchiarico, Timothy Counihan, Gearòid Ò Laighin, Joan Cabestany
BACKGROUND: Our group earlier developed a small monitoring device, which uses accelerometer measurements to accurately detect motor fluctuations in patients with Parkinson's (On and Off state) based on an algorithm that characterizes gait through the frequency content of strides. To further validate the algorithm, we studied the correlation of its outputs with the motor section of the Unified Parkinson's Disease Rating Scale part-III (UPDRS-III). METHOD: Seventy-five patients suffering from Parkinson's disease were asked to walk both in the Off and the On state while wearing the inertial sensor on the waist...
2017: Frontiers in Neurology
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