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https://www.readbyqxmd.com/read/28527414/structural-characterization-and-discrimination-of-the-paris-polyphylla-var-yunnanensis-and-paris-vietnamensis-based-on-metabolite-profiling-analysis
#1
Li-Ping Kang, Yuan-Yuan Huang, Zhi-Lai Zhan, Da-Hui Liu, Hua-Sheng Peng, Tie-Gui Nan, Yuan Zhang, Qing-Xiu Hao, Jin-Fu Tang, Shou-Dong Zhu, Guang Yang, Lan-Ping Guo, Min Chen, Lu-Qi Huang
This study aimed to distinguish the rhizomes of Paris polyphylla var. yunnanensis (Franch) Hand Mazz (PPY) and Paris veitnamensis (Takht.) H. Li (PV) using metabolomics-based ultra high-performance liquid chromatography coupled with quadrupole time-of-fligh mass spectrometry (UHPLC/Q-TOF MS). First, the UHPLC/Q-TOF MS approach was optimized for metabolite profiling. Then, the MS data were processed using UNIFI™ combined with an in-house library to automatically characterize the metabolites. Based on the exact mass information, the fragmentation characteristics, and the retention time of compounds, and the fragmentation mechanism and retention behavior of steroidal glycosides in the references, the structures identified by UNIFI were further verified...
May 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28527345/a-literature-review-of-blood-concentrations-of-new-psychoactive-substances-classified-as-phenethylamines-aminoindanes-arylalkylamines-arylcyclohexylamines-and-indolalkylamines
#2
REVIEW
Ritva Karinen, Gudrun Høiseth
Interpretation of blood concentrations of new psychoactive substances (NPS) requires comparison of the results to previously published case reports; as only a few experimental studies for these substances exist. A large number of articles representing single or multiple cases have been published for a great number of substances, making a unified overview difficult. In this review we have collected all published blood concentrations from the NPS groups classified as phenethylamines, aminoindanes, arylalkylamines, arylcyclohexylamines, and indolalkylamines, and also included unpublished results for MPA, MXE, 4-FMA, 4-FA and 4-MA analyzed in our laboratory...
March 21, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28527003/the-effects-of-kanizsa-contours-on-temporal-integration-and-attention-in-rapid-serial-visual-presentation
#3
Aytaç Karabay, Elkan G Akyürek
Performance in rapid serial visual presentation tasks has been shown to depend on the temporal integration of target stimuli when they are presented in direct succession. Temporal target integration produces a single, combined representation of visually compatible stimuli, which is comparatively easy to identify. It is currently unknown to what extent target compatibility affects this perceptual behavior, because it has not been studied systematically to date. In the present study, the effects of compatibility on temporal integration and attention were investigated by manipulating the Gestalt properties of target features...
May 19, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28526714/constans-imparts-dna-sequence-specificity-to-the-histone-fold-nf-yb-nf-yc-dimer
#4
Nerina Gnesutta, Roderick W Kumimoto, Swadhin Swain, Matteo Chiara, Chamindika Siriwardana, David Stephen Horner, Ben F Holt, Roberto Mantovani
NF-Y is a heterotrimeric transcription factor that binds CCAAT elements. The NF-Y trimer is composed of a Histone Fold Domain (HFD) dimer (NF-YB/NF-YC) and NF-YA, which confers DNA sequence-specificity. NF-YA shares a conserved domain with the CCT (CONSTANS, CONSTANS-LIKE, TOC1) proteins. We show that CONSTANS (CO/BBX1), a master flowering regulator, forms a trimer with Arabidopsis NF-YB2/NF-YC3 to efficiently bind the CORE element of the FT promoter. We term this complex NF-CO. Using saturation mutagenesis EMSAs and RNA-Seq profiling of co, nf-yb, and nf-yc mutants, we identify CCACA elements as the core NF-CO binding site...
May 19, 2017: Plant Cell
https://www.readbyqxmd.com/read/28526642/-asleep-deep-brain-stimulation-surgery-a-critical-review-of-the-literature
#5
REVIEW
Tsinsue Chen, Zaman Mirzadeh, Francisco A Ponce
OBJECTIVE: Although performing deep brain stimulation (DBS) with the patient under general anesthesia without microelectrode recording (MER) or intraoperative test stimulation (ITS) for movement disorders ("asleep" DBS) has become increasingly popular, its feasibility is based on the untested assumption that stereotactic accuracy correlates with positive clinical outcomes. To investigate outcomes after asleep DBS without MER or neurophysiological testing, we reviewed the medical literature on the topic...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28526354/outline-of-a-unified-darwinian-evolutionary-theory-for-physical-and-biological-systems
#6
REVIEW
Carlos Baladrón, Andrei Khrennikov
The scheme of a unified Darwinian evolutionary theory for physical and biological systems is described. Every physical system is methodologically endowed with a classical information processor what turns every system into an agent being also susceptible to evolution. Biological systems retain this structure as natural extensions of physical systems from which they are built up. Optimization of information flows turns out to be the key element to study the possible emergence of quantum behavior and the unified Darwinian description of physical and biological systems...
May 16, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28526295/large-scale-exploratory-genetic-analysis-of-cognitive-impairment-in-parkinson-s-disease
#7
Ignacio F Mata, Catherine O Johnson, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Vivianna M Van Deerlin, Beate Ritz, Rebecca Rausch, Stewart A Factor, Cathy Wood-Siverio, Joseph F Quinn, Kathryn A Chung, Amie L Peterson-Hiller, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Dora Yearout, Shu-Ching Hu, Brenna A Cholerton, Thomas J Montine, Karen L Edwards, Cyrus P Zabetian
Cognitive impairment is a common and disabling problem in Parkinson's disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficits in PD might provide a clearer understanding of the pathophysiology underlying this important nonmotor feature. We genotyped 1105 PD patients from the PD Cognitive Genetics Consortium for 249,336 variants using the NeuroX array. Participants underwent assessments of learning and memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), working memory/executive function (Letter-Number Sequencing and Trail Making Test [TMT] A and B), language processing (semantic and phonemic verbal fluency), visuospatial abilities (Benton Judgment of Line Orientation [JoLO]), and global cognitive function (Montreal Cognitive Assessment)...
April 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28525887/an-updated-meta-analysis-of-amantadine-for-treating-dyskinesia-in-parkinson-s-disease
#8
Min Kong, Maowen Ba, Chao Ren, Ling Yu, Shengjie Dong, Guoping Yu, Hui Liang
In recent years, a few of randomized controlled trials (RCTs) about amantadine for treating dyskinesia in Parkinson's disease (PD) were completed. Here, we conducted a systematic literature review about the clinical research to provide the updated evidence for treating dyskinesia. Electronic search of Medline, PubMed, Cochrane Library, and other databases up to May 2016 for relevant studies was performed. We selected the Unified Parkinson's Disease Rating Scale IV (UPDRS IV) and Dyskinesia Rating Scales (DRS) as efficacy outcomes of amantadine on dyskinesia...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524817/functional-dissociation-of-stimulus-intensity-encoding-and-predictive-coding-of-pain-in-the-insula
#9
Stephan Geuter, Sabrina Boll, Falk Eippert, Christian Büchel
The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus intensity or additive effects of intensity and expectations, respectively. By contrast, predictive coding theories provide a unified framework explaining how perception is shaped by the integration of beliefs about the world with mismatches resulting from the comparison of these believes against sensory input. Using functional magnetic resonance imaging during a probabilistic heat pain paradigm, we investigated which computations underlie pain perception...
May 19, 2017: ELife
https://www.readbyqxmd.com/read/28524675/experimental-determination-of-dynamical-lee-yang-zeros
#10
Kay Brandner, Ville F Maisi, Jukka P Pekola, Juan P Garrahan, Christian Flindt
Statistical physics provides the concepts and methods to explain the phase behavior of interacting many-body systems. Investigations of Lee-Yang zeros-complex singularities of the free energy in systems of finite size-have led to a unified understanding of equilibrium phase transitions. The ideas of Lee and Yang, however, are not restricted to equilibrium phenomena. Recently, Lee-Yang zeros have been used to characterize nonequilibrium processes such as dynamical phase transitions in quantum systems after a quench or dynamic order-disorder transitions in glasses...
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28524126/-impact-of-sagittal-balance-parameters-on-life-quality-in-elderly-and-senile-patients-after-surgery-for-degenerative-lumbar-spine-stenosis
#11
V S Klimov, I I Vasilenko, A V Evsyukov, E V Amelina
INTRODUCTION: As the life span and proportion of people over 65 years increase, the incidence of degenerative lumbar spine stenosis grows proportionally. Various parameters of the spinopelvic relationships are used to predict surgical treatment outcomes in patients with degenerative spine diseases. There are no unified protocols for evaluation, in terms of the sagittal balance, of surgical treatment outcomes in elderly patients. PURPOSE: To study the impact of sagittal balance parameters on the life quality of elderly and senile patients after surgery for degenerative stenosis of the lumbar spine...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28524117/ebutterfly-leveraging-massive-online-citizen-science-for-butterfly-consevation
#12
Kathleen L Prudic, Kent P McFarland, Jeffrey C Oliver, Rebecca A Hutchinson, Elizabeth C Long, Jeremy T Kerr, Maxim Larrivée
Data collection, storage, analysis, visualization, and dissemination are changing rapidly due to advances in new technologies driven by computer science and universal access to the internet. These technologies and web connections place human observers front and center in citizen science-driven research and are critical in generating new discoveries and innovation in such fields as astronomy, biodiversity, and meteorology. Research projects utilizing a citizen science approach address scientific problems at regional, continental, and even global scales otherwise impossible for a single lab or even a small collection of academic researchers...
May 18, 2017: Insects
https://www.readbyqxmd.com/read/28524110/infrared-thermography-sensor-for-temperature-and-speed-measurement-of-moving-material
#13
Rubén Usamentiaga, Daniel Fernando García
Infrared thermography offers significant advantages in monitoring the temperature of objects over time, but crucial aspects need to be addressed. Movements between the infrared camera and the inspected material seriously affect the accuracy of the calculated temperature. These movements can be the consequence of solid objects that are moved, molten metal poured, material on a conveyor belt, or just vibrations. This work proposes a solution for monitoring the temperature of material in these scenarios. In this work both real movements and vibrations are treated equally, proposing a unified solution for both problems...
May 18, 2017: Sensors
https://www.readbyqxmd.com/read/28522206/functional-properties-of-the-mitochondrial-carrier-system
#14
REVIEW
Eric B Taylor
The mitochondrial carrier system (MCS) transports small molecules between mitochondria and the cytoplasm. It is integral to the core mitochondrial function to regulate cellular chemistry by metabolism. The mammalian MCS comprises the transporters of the 53-member canonical SLC25A family and a lesser number of identified noncanonical transporters. The recent discovery and investigations of the mitochondrial pyruvate carrier (MPC) illustrate the diverse effects a single mitochondrial carrier may exert on cellular function...
May 15, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28521796/effects-of-nurse-telesupport-on-transition-between-specialized-and-primary-care-in-diabetic-patients-study-protocol-for-a-randomized-controlled-trial
#15
Ana Marina Moreira, Roberta Marobin, Dimitris Varvaki Rados, Camila Bergonsi de Farias, Sabrina Coelli, Bárbara Luiza Bernardi, Lívia de Almeida Faller, Laura Ferraz Dos Santos, Ana Maria Matzenbacher, Natan Katz, Erno Harzheim, Sandra Pinho Silveiro
BACKGROUND: According to the Global Diabetes Plan, a unified health system with preventive and educational strategies is essential to proper diabetes care and primary settings should be the main site of care. In Brazil, there is limited access to outpatient hospital diabetes services, while primary-care diabetes support is underutilized. Telemedicine can be a useful adjunct to support discharge of stable patients with type 2 diabetes to the primary care setting. In this paper, we present a randomized controlled trial (RCT) protocol designed to evaluate the effects of telehealth support for stable type 2 diabetes patients discharged from hospital outpatient diabetes clinics...
May 18, 2017: Trials
https://www.readbyqxmd.com/read/28521712/biomarkers-for-sarcopenia-reductionism-vs-complexity
#16
Riccardo Calvani, Anna Picca, Matteo Cesari, Matteo Tosato, Federico Marini, Ester Manes-Gravina, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and the burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28516916/unified-model-for-singlet-fission-within-a-non-conjugated-covalent-pentacene-dimer
#17
Bettina S Basel, Johannes Zirzlmeier, Constantin Hetzer, Brian T Phelan, Matthew D Krzyaniak, S Rajagopala Reddy, Pedro B Coto, Noah E Horwitz, Ryan M Young, Fraser J White, Frank Hampel, Timothy Clark, Michael Thoss, Rik R Tykwinski, Michael R Wasielewski, Dirk M Guldi
When molecular dimers, crystalline films or molecular aggregates absorb a photon to produce a singlet exciton, spin-allowed singlet fission may produce two triplet excitons that can be used to generate two electron-hole pairs, leading to a predicted ∼50% enhancement in maximum solar cell performance. The singlet fission mechanism is still not well understood. Here we report on the use of time-resolved optical and electron paramagnetic resonance spectroscopy to probe singlet fission in a pentacene dimer linked by a non-conjugated spacer...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28515235/insulin-like-growth-factor-signaling-regulates-developmental-trajectory-associated-with-diapause-in-embryos-of-the-annual-killifish-austrofundulus-limnaeus
#18
S Cody Woll, Jason E Podrabsky
Annual killifishes exhibit a number of unique life history characters including the occurrence of embryonic diapause, unique cell movements associated with dispersion and subsequent reaggregation of the embryonic blastomeres, and a short post-embryonic life span. Insulin-like growth factor (IGF) signaling is known to play a role in the regulation of metabolic dormancy in a number of animals but has not been explored in annual killifishes. The abundance of IGF proteins during development, and the developmental effects of blocking IGF signaling by pharmacological inhibition of the insulin-like growth factor I receptor (IGF1R) were explored in embryos of the annual killifish Austrofundulus limnaeus Blocking of IGF signaling in embryos that would normally escape entrance into diapause resulted in a phenotype that was remarkably similar to embryos entering diapause...
May 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28514628/a-modest-proposal-for-unifying-macroevolution-and-ecosystem-ecology
#19
Matthew W Pennell, Mary I O'Connor
No abstract text is available yet for this article.
June 2017: American Naturalist
https://www.readbyqxmd.com/read/28513920/moisture-induced-greening-of-the-south-asia-over-the-past-three-decades
#20
Xiaoyi Wang, Tao Wang, Dan Liu, Hui Guo, Huabing Huang, Yutong Zhao
South Asia experienced a weakening of summer monsoon circulation in the past several decades, resulting in rainfall decline in wet regions. In comparison to other tropical ecosystems, quantitative assessments of the extent and triggers of vegetation change are lacking in assessing climate-change impacts over South Asia dominated by crops. Here we use satellite-based normalized difference vegetation index (NDVI) to quantify spatial-temporal changes in vegetation greenness, and find a widespread annual greening trend that stands in contrast to the weakening of summer monsoon circulation particularly over the last decade...
May 17, 2017: Global Change Biology
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