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https://www.readbyqxmd.com/read/29166477/regional-differences-in-infection-control-conditions-in-a-sample-of-primary-health-care-services-in-brazil
#1
Mauro Henrique Nogueira Guimarães de Abreu, Vera Lúcia Silva Resende, Kyu Ha Lee, Antônio Thomaz Gonzaga da Matta-Machado, Jacqueline Rose Starr
International guidelines have pointed out the importance of the physical environment of health care facilities in preventing and controlling infection. We aimed to describe the physical environment of dental care facilities in Brazil in 2014, focusing on characteristics designed to control infections. Exactly 16,202 dental offices in the Brazilian Unified National Health System (SUS) participated in this survey. Trained researchers extracted information about the infection control characteristics of health facilities by using a structured instrument...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166109/temperature-and-chain-length-dependence-of-ultrafast-vibrational-dynamics-of-thiocyanate-in-alkylimidazolium-ionic-liquids-a-random-walk-on-a-rugged-energy-landscape
#2
Thomas Brinzer, Sean Garrett-Roe
Ultrafast two-dimensional infrared spectroscopy of a thiocyanate vibrational probe (SCN(-)) was used to investigate local dynamics in alkylimidazolium bis-[trifluoromethylsulfonyl]imide ionic liquids ([Imn,1][Tf2N], n = 2, 4, 6) at temperatures from 5 to 80 °C. The rate of frequency fluctuations reported by SCN(-) increases with increasing temperature and decreasing alkyl chain length. Temperature-dependent correlation times scale proportionally to temperature-dependent bulk viscosities of each ionic liquid studied...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165837/pulse-duration-settings-in-subthalamic-stimulation-for-parkinson-s-disease
#3
Frank Steigerwald, Lars Timmermann, Andrea Kühn, Alfons Schnitzler, Martin M Reich, Anna Dalal Kirsch, Michael Thomas Barbe, Veerle Visser-Vandewalle, Julius Hübl, Christoph van Riesen, Stefan Jun Groiss, Alexia-Sabine Moldovan, Sherry Lin, Stephen Carcieri, Ljubomir Manola, Jens Volkmann
BACKGROUND: Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. METHODS: A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome)...
November 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29165783/after-action-review-of-the-2009-10-h1n1-influenza-outbreak-response-ohio-s-public-health-system-s-performance
#4
William A Mase, Beth Bickford, Casey L Thomas, Shamika D Jones, Michael Bisesi
OBJECTIVE: In early 2009, H1N1 influenza was identified within the human population. Centers for Disease Control and Prevention (CDC) officials responded with focused assessment, policy development, and assurances. The response was mobilized through efforts including procurement of adequate vaccine supply, local area span of control, materials acquisition, and facilities and resource identification. METHODS: Qualitative evaluation of the assurance functions specific to the system's ability to assure safe and healthy conditions are reported...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29165776/model-driven-gas-exchange-monitoring-in-the-critically-ill
#5
Cosmin Ion Balan, Adrian View-Kim Wong
Understanding pulmonary gas exchange performance is a dynamic process which, depending on clinical context, exhibits different levels of complexity. Global tools such as tension-based indexes yield clinically crucial information under very specific conditions. Yet, accurate mechanistic insight can only originate in model-based tools. One-parameter models such as shunt or dead space are well established in clinical practice whilst two or three-parameter models have just been advanced and their role is yet to be delineated...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29165610/gramene-2018-unifying-comparative-genomics-and-pathway-resources-for-plant-research
#6
Marcela K Tello-Ruiz, Sushma Naithani, Joshua C Stein, Parul Gupta, Michael Campbell, Andrew Olson, Sharon Wei, Justin Preece, Matthew J Geniza, Yinping Jiao, Young Koung Lee, Bo Wang, Joseph Mulvaney, Kapeel Chougule, Justin Elser, Noor Al-Bader, Sunita Kumari, James Thomason, Vivek Kumar, Daniel M Bolser, Guy Naamati, Electra Tapanari, Nuno Fonseca, Laura Huerta, Haider Iqbal, Maria Keays, Alfonso Munoz-Pomer Fuentes, Amy Tang, Antonio Fabregat, Peter D'Eustachio, Joel Weiser, Lincoln D Stein, Robert Petryszak, Irene Papatheodorou, Paul J Kersey, Patti Lockhart, Crispin Taylor, Pankaj Jaiswal, Doreen Ware
Gramene (http://www.gramene.org) is a knowledgebase for comparative functional analysis in major crops and model plant species. The current release, #54, includes over 1.7 million genes from 44 reference genomes, most of which were organized into 62,367 gene families through orthologous and paralogous gene classification, whole-genome alignments, and synteny. Additional gene annotations include ontology-based protein structure and function; genetic, epigenetic, and phenotypic diversity; and pathway associations...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29164312/efficacy-and-safety-of-rotigotine-in-elderly-patients-with-parkinson-s-disease-in-comparison-with-the-non-elderly-a-post-hoc-analysis-of-randomized-double-blind-placebo-controlled-trials
#7
Masahiro Nomoto, Hirotaka Iwaki, Hiroyuki Kondo, Masaya Sakurai
Rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (D1-D5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. The age of the patient impacts the effect and adverse events of anti-parkinsonian treatment. We conducted a post hoc analysis on three randomized, double-blind, placebo-controlled trials performed in Japan to clarify the difference of anti-parkinsonian treatment in elderly and non-elderly patients. Data from two combination therapy trials (with levodopa) in advanced stage Parkinson's disease patients and one monotherapy trial in early stage patients were pooled and grouped by age (non-elderly aged < 70, elderly aged 70 +)...
November 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29163340/the-dominant-subthalamic-nucleus-phenomenon-in-bilateral-deep-brain-stimulation-for-parkinson-s-disease-evidence-from-a-gait-analysis-study
#8
Mario Giorgio Rizzone, Maurizio Ferrarin, Michele Maria Lanotte, Leonardo Lopiano, Ilaria Carpinella
Background: It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives: Since disability in PD patients is often related to gait problems, in this study, we wanted to investigate in a group of patients bilaterally implanted for STN-DBS: (1) if it was possible to identify a subgroup of subjects with a dominant STN; (2) in the case, if the unilateral stimulation of the dominant STN was capable to improve gait abnormalities, as assessed by instrumented multifactorial gait analysis, similarly to what observed with bilateral stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163137/multiple-evidences-for-association-between-cognitive-impairment-and-dysglycemia-in-parkinson-s-disease-implications-for-clinical-practice
#9
Liu Yang, Zhilin Chen, Bo Li, Meihua Wang, Lijia Yu, Ying Wan, Jing Gan, Yu Zhang, Zhenguo Liu, Xijin Wang
Background and purpose: It remains unclear about the etiopathogenesis of cognitive impairment (CI) in Parkinson's disease (PD). Since diabetes mellitus (DM) has been shown to be associated with CI in several diseases, we examined the association between CI and dysglycemia in PD. Methods: Enrolled PD patients completed a series of clinical and neuropsychological assessments. Motor symptoms were determined by Hohen-Yahr staging (H-Y staging) and Unified Parkinson's Disease Rating Scale - motor score (UPDRS-III)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29163063/acetylcholine-neuromodulation-in-normal-and-abnormal-learning-and-memory-vigilance-control-in-waking-sleep-autism-amnesia-and-alzheimer-s-disease
#10
Stephen Grossberg
Adaptive Resonance Theory, or ART, is a neural model that explains how normal and abnormal brains may learn to categorize and recognize objects and events in a changing world, and how these learned categories may be remembered for a long time. This article uses ART to propose and unify the explanation of diverse data about normal and abnormal modulation of learning and memory by acetylcholine (ACh). In ART, vigilance control determines whether learned categories will be general and abstract, or specific and concrete...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29162647/a-unifying-biology-of-sex-steroid-induced-apoptosis-in-prostate-and-breast-cancers
#11
Philipp Y Maximov, Balkees Abderrahman, Ramona F Curpan, Yousef A Hawsawi, Ping Fan, V Craig Jordan
Prostate and breast cancer are the two cancers with the highest incidence in men and women, respectively. Here we focus on the known biology of acquired resistance to antihormone therapy of prostate and breast cancer and compare laboratory and clinical similarities in the evolution of the disease. Laboratory studies and clinical observations in prostate and breast cancer demonstrate that cell selection pathways occur during acquired resistance to antihormonal therapy. Following sex steroid deprivation, both prostate and breast cancer models show an initial increased acquired sensitivity to the growth potential of sex steroids...
November 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29162090/assessment-of-motivational-interviewing-a-qualitative-study-of-response-process-validity-content-validity-and-feasibility-of-the-motivational-interviewing-target-scheme-mits-in-general-practice
#12
Riëtta Oberink, Saskia M Boom, Nynke van Dijk, Mechteld R M Visser
BACKGROUND: The Motivational Interviewing target Scheme (MITS) is an instrument to assess competency in Motivational Interviewing (MI) and can be used to assess MI in long and brief consultations. In this qualitative study we examined two sources of the Unified Model of Validity, the current standard of assessment validation, in the context of General Practice. We collected evidence concerning response process validity and content validity of the MITS in general practice. Furthermore, we investigated its feasibility...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29161079/a-new-frontier-in-immunometabolism-cholesterol-in-lung-health-and-disease
#13
Michael B Fessler
The lung has a unique relationship to cholesterol that is shaped by its singular physiology. On the one hand, the lungs receive the full cardiac output and have a predominant dependence on plasma lipoprotein uptake for their cholesterol supply. On the other hand, surfactant lipids, including cholesterol, are continually susceptible to oxidation owing to direct environmental exposure and must be cleared or recycled because of the very narrow biophysical mandates placed upon surfactant lipid composition. Interestingly, increased lipid-laden macrophage "foam cells" have been noted in a wide range of human lung pathologies...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29160844/altered-aconitase-2-activity-in-huntington-s-disease-peripheral-blood-cells-and-mouse-model-striatum
#14
Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang
Huntington's disease (HD) is caused by an unstable cytosine adenine guanine (CAG) trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin protein. Previously, we identified several up- and down-regulated protein molecules in the striatum of the Hdh((CAG)150) knock-in mice at 16 months of age, a mouse model which is modeling the early human HD stage. Among those molecules, aconitase 2 (Aco2) located in the mitochondrial matrix is involved in the energy generation and susceptible to increased oxidative stress that would lead to inactivation of Aco2 activity...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160467/pharmaceutical-services-in-primary-health-care-interfederative-agreement-in-the-development-of-pharmaceutical-policies-in-the-brazilian-unified-health-system-sus
#15
Karen Sarmento Costa, Noêmia Urruth Leão Tavares, José Miguel do Nascimento, Sotero Serrate Mengue, Juliana Álvares, Augusto Afonso Guerra, Francisco de Assis Acurcio, Orlando Mario Soeiro
No abstract text is available yet for this article.
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160466/pharmaceutical-services-in-the-primary-health-care-of-the-brazilian-unified-health-system-advances-and-challenges
#16
Karen Sarmento Costa, Noêmia Urruth Leão Tavares, José Miguel do Nascimento, Sotero Serrate Mengue, Juliana Álvares, Augusto Afonso Guerra, Francisco de Assis Acurcio, Orlando Mario Soeiro
This study is a synthesis of the main results of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), Evaluation Component of the Basic Pharmaceutical Services. Based on the critical narrative of the elements of Brazil's pharmaceutical policies, we discuss aspects related to the structure of the pharmaceutical services, the medicines' sanitary state, human resources, access to medicines, rational use and management...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160464/use-of-medicines-by-patients-of-the-primary-health-care-of-the-brazilian-unified-health-system
#17
Clarisse Melo Franco Neves Costa, Micheline Rosa Silveira, Francisco de Assis Acurcio, Augusto Afonso Guerra, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite, Ediná Alves Costa, Renata Cristina Rezende Macedo do Nascimento, Vânia Eloísa de Araújo, Juliana Álvares
OBJECTIVE: To characterize the use of medicines by patients of the primary health care of the Brazilian Unified Health System (SUS). METHODS: This is a cross-sectional, exploratory, and descriptive study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). Interviews were carried out with patients present in the services by semi-structured questionnaires...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160463/access-to-medicines-by-patients-of-the-primary-health-care-in-the-brazilian-unified-health-system
#18
Juliana Álvares, Augusto Afonso Guerra, Vânia Eloisa de Araújo, Alessandra Maciel Almeida, Carolina Zampirolli Dias, Bruna de Oliveira Ascef, Ediná Alves Costa, Ione Aquemi Guibu, Orlando Mario Soeiro, Silvana Nair Leite, Margô Gomes de Oliveira Karnikowski, Karen Sarmento Costa, Francisco de Assis Acurcio
OBJECTIVE: To evaluate the access to medicines in primary health care of the Brazilian Unified Health System (SUS), from the patients' perspective. METHODS: This is a cross-sectional study that used data from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Services, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), conducted by interviews with 8,591 patients in cities of the five regions of Brazil...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160460/polypharmacy-a-challenge-for-the-primary-health-care-of-the-brazilian-unified-health-system
#19
Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Isabel Cristina Gomes, Micheline Rosa Silveira, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio
OBJECTIVE: To characterize the polypharmacy in primary health care patients and to identify its associated factors. METHODS: This is a cross-sectional, exploratory, and evaluative study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). The variable of interest was polypharmacy, defined as the use of five or more medicines...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160458/health-related-quality-of-life-of-patients-of-brazilian-primary-health-care
#20
Bruna de Oliveira Ascef, João Paulo Amaral Haddad, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite, Micheline Rosa Silveira
OBJECTIVE: To analyze the Health-Related Quality of Life (HRQoL) of patients of the primary health care of the Brazilian Unified Health System (SUS) and its associated factors. METHODS: This is a cross-sectional study with data from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). Data were collected with a questionnaire that included the EuroQol 5 Dimensions (EQ-5D) instrument...
November 13, 2017: Revista de Saúde Pública
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