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https://www.readbyqxmd.com/read/28449263/multi-dice-r-package-for-comparative-population-genomic-inference-under-hierarchical-co-demographic-models-of-independent-single-population-size-changes
#1
Alexander T Xue, Michael J Hickerson
Population genetic data from multiple taxa can address comparative phylogeographic questions about community-scale response to environmental shifts, and a useful strategy to this end is to employ hierarchical co-demographic models that directly test multi-taxa hypotheses within a single, unified analysis while benefiting in statistical power from aggregating datasets. This approach has been applied to classical phylogeographic datasets such as mitochondrial barcodes as well as reduced-genome polymorphism datasets that can yield 10,000s of SNPs, produced by emergent technologies such as RAD-seq and GBS...
April 27, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28449257/the-development-and-application-of-random-match-probabilities-to-firearm-and-toolmark-identification
#2
John E Murdock, Nicholas D K Petraco, John I Thornton, Michael T Neel, Todd J Weller, Robert M Thompson, James E Hamby, Eric R Collins
The field of firearms and toolmark analysis has encountered deep scrutiny of late, stemming from a handful of voices, primarily in the law and statistical communities. While strong scrutiny is a healthy and necessary part of any scientific endeavor, much of the current criticism leveled at firearm and toolmark analysis is, at best, misinformed and, at worst, punditry. One of the most persistent criticisms stems from the view that as the field lacks quantified random match probability data (or at least a firm statistical model) with which to calculate the probability of a false match, all expert testimony concerning firearm and toolmark identification or source attribution is unreliable and should be ruled inadmissible...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28448135/total-synthesis-of-%C3%A2-lycojaponicumin-d-and-lycodoline-type-lycopodium-alkaloids
#3
Xian-He Zhao, Qing Zhang, Ji-Yuan Du, Xin-Yun Lu, Ye-Xing Cao, Yu-Hua Deng, Chun-An Fan
Lycopodium alkaloids with structural diversity and biological significance have been stimulating an increasing interest in synthetic and medicinal communities, in which inspiration and exploration of their related biogenetic relationship generally comprises one of the major concerns. Driven by the plausible biogenetic entry to lycojaponicumin D as the first member of Lycopodium alkaloids having structurally unusual C(3)-C(13) linked scaffold, a new connection with lycodoline has been proposed and discovered on the basis of the design of an unprecedented bioinspired tandem fragmentation/Mannich reaction...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28447850/links-between-temporal-acuity-and-multisensory-integration-across-life-span
#4
Ryan A Stevenson, Sarah H Baum, Juliane Krueger, Paul A Newhouse, Mark T Wallace
The temporal relationship between individual pieces of information from the different sensory modalities is one of the stronger cues to integrate such information into a unified perceptual gestalt, conveying numerous perceptual and behavioral advantages. Temporal acuity, however, varies greatly over the life span. It has previously been hypothesized that changes in temporal acuity in both development and healthy aging may thus play a key role in integrative abilities. This study tested the temporal acuity of 138 individuals ranging in age from 5 to 80...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28447817/a-unified-framework-for-bounded-and-unbounded-numerical-estimation
#5
Dan Kim, John E Opfer
Representations of numerical value have been assessed by using bounded (e.g., 0-1,000) and unbounded (e.g., 0-?) number-line tasks, with considerable debate regarding whether 1 or both tasks elicit unique cognitive strategies (e.g., addition or subtraction) and require unique cognitive models. To test this, we examined how well a mixed log-linear model accounted for 86 5- to 9-year-olds' estimates on bounded and unbounded number-line tasks and how well it predicted mathematical performance. Compared with mixtures of 4 alternative models, the mixed log-linear model better predicted 76% of individual children's estimates on bounded number lines and 100% of children's estimates on unbounded number lines...
April 27, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28447596/on-the-penrose-and-taylor-socolar-hexagonal-tilings
#6
Jeong Yup Lee, Robert V Moody
The intimate relationship between the Penrose and the Taylor-Socolar tilings is studied, within both the context of double hexagon tiles and the algebraic context of hierarchical inverse sequences of triangular lattices. This unified approach produces both types of tilings together, clarifies their relationship and offers straightforward proofs of their basic properties.
May 1, 2017: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/28446646/randomized-controlled-trial-of-deutetrabenazine-for-tardive-dyskinesia-the-arm-td-study
#7
Hubert H Fernandez, Stewart A Factor, Robert A Hauser, Joohi Jimenez-Shahed, William G Ondo, L Fredrik Jarskog, Herbert Y Meltzer, Scott W Woods, Danny Bega, Mark S LeDoux, David R Shprecher, Charles Davis, Mat D Davis, David Stamler, Karen E Anderson
OBJECTIVE: To determine the efficacy and safety of deutetrabenazine as a treatment for tardive dyskinesia (TD). METHODS: One hundred seventeen patients with moderate to severe TD received deutetrabenazine or placebo in this randomized, double-blind, multicenter trial. Eligibility criteria included an Abnormal Involuntary Movement Scale (AIMS) score of ≥6 assessed by blinded central video rating, stable psychiatric illness, and stable psychoactive medication treatment...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28444956/structural-insights-into-the-recognition-of-n%C3%A2-aryl-and-c8-aryl-dna-lesions-by-the-repair-protein-xpa-rad14
#8
Charlotte Ebert, Nina Simon, Sabine Schneider, Thomas Carell
Aromatic amines are strongly carcinogenic compounds. They are activated in the liver to give reactive nitrenium ions that are known to react with the nucleobases within the DNA duplex. The reaction occurs predominantly at the C8-position of the dG base, which gives C8-acetyl-aryl-, or C8-aryl-dG adducts in an electrophilic aromatic substitution reaction. Alternatively, reaction with the exocyclic 2-NH₂ group is observed. While the C8-adducts retain the base pairing properties, base pairing is strongly compromised in the case of the N²-adducts...
April 26, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28444559/effectiveness-of-an-interdisciplinary-medical-hospital-admission-center-the-role-of-the-dental-section-in-the-interdisciplinary-system-for-perioperative-management-of-patients-awaiting-surgery
#9
Akifumi Enomoto, Eri Morikage, Takeshi Shimoide, Kazuhide Matsunaga, Suguru Hamada
Perioperative oral functional management (POFM) involves total oral management of a patient before surgery. Considerable benefits have been reported, but POFM remains scarce in medical settings. An interdisciplinary Medical Hospital Admission Center (MHAC) opened in our hospital in December 2014, and has since provided unified perioperative management for patients. This study reports on the clinical system and contributions of the systematized, standardized POFM applied through the MHAC. Patients awaiting surgery undergo oral screening before admission, with patients classified into three groups: red, needing surgical oral management (tooth extraction or other oral surgery) before surgery; yellow, needing non-surgical oral management before surgery, due to the planned surgery or the risk of tooth injury in connection with general anesthesia; or green, patients with good oral hygiene considered capable of suitable oral self-management...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28444510/starvation-signals-in-yeast-are-integrated-to-coordinate-metabolic-reprogramming-and-stress-response-to-ensure-longevity
#10
REVIEW
Nianshu Zhang, Lu Cao
Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal transduction pathways (mainly TOR and PKA) have been shown to regulate CLS, yet it is poorly understood how the starvation signals transduced via these pathways lead to CLS extension. Using reporters whose expressions are induced by glucose starvation, we have screened the majority of the 'signaling' mutants in the yeast genome and identified many genes that are necessary for stress response...
April 25, 2017: Current Genetics
https://www.readbyqxmd.com/read/28444053/a-systematic-review-of-the-process-of-regionalization-of-brazil-s-unified-health-system-sus
#11
Guilherme Arantes Mello, Ana Paula Chancharulo de Morais Pereira, Liza Yurie Teruya Uchimura, Fabíola Lana Iozzi, Marcelo Marcos Piva Demarzo, Ana Luiza d'Ávila Viana
This review focuses only on specific studies into the SUS regionalization process, which were based on empirical results and published since 2006, when the SUS was already under the aegis of the Pact for Health framework. It was found that the regionalization process is now underway in all spheres of government, subject to a set of challenges common to the different realities of the country. These include, primarily, that committee-structured entities are valued as spaces for innovation, yet also strive to overcome the bureaucratic and clientelist political culture...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444052/healthcare-regions-and-their-care-networks-an-organizational-systemic-model-for-sus
#12
Lenir Santos
This paper describes a comprehensive effort to develop studies regarding Brazil's Unified Healthcare System (SUS), as a result of the combination of public services in a network that follows a region-based rationale (tripartite organization). The SUS emerges from such an integration and should be organized as such. The intention is to demonstrate that this type of organization is essential, given that Brazil is organized as a Federation, and all three governmental levels are, in a broad sense, equally responsible for healthcare...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444051/analysis-of-the-unified-health-system-funding-and-expenditure-in-the-municipalities-of-the-rota-dos-bandeirantes-health-region-state-of-s%C3%A3-o-paulo-brazil
#13
João Alves Dos Santos, Áquilas Nogueira Mendes, Antônio Carlos Pereira, Luiz Renato Paranhos
The national scenario of lack of resources in the Brazilian Unified Health System (SUS) has led to major differences in the municipalities funding models. Thus, this study aims to analyze SUS funding and expenditure in seven cities of the Rota dos Bandeirantes health region, State of São Paulo, SP, Brazil, from 2009 to 2012. Settled expenditure indicators were collected from the Public Health Budgets Information System (SIOPS) for analysis, showing descriptive data with absolute and relative frequency calculations...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444050/ambulatory-municipal-regulation-of-the-unified-health-system-services-in-rio-de-janeiro-advances-limitations-and-challenges
#14
Luiz Felipe Pinto, Daniel Soranz, Mariana Tomasi Scardua, Iandara de Moura Silva
Federalism is basis of the Republic of Brazil which is made up of the union of states, municipalities and the Federal District, with the basic principle of political and administrative decentralization in all political, economic and social relations. In the health sector, the primary health care provider should be able to integrate all care that the patient receives through the coordination of health services. This article aims to evaluate the results of referrals for consultations and outpatient examinations in primary health care in the municipality of Rio de Janeiro, highlighting the advances, limitations and challenges for management at the local level...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444044/comments-on-the-organization-of-pharmaceutical-services-by-health-region-in-brazil-s-unified-health-system
#15
Suetônio Queiroz Araújo, Karen Sarmento Costa, Vera Lucia Luiza, Carmen Lavras, Eucilene Alves Santana, Noemia Urruth Leão Tavares
This study aimed to describe and characterize the pharmaceutical services provided in Brazil's Unified Health System (SUS) from the point of view of the healthcare networks that are organized by region in the QualiSUS-Rede Project. This was a cross-sectional study, with data collected from December 2013 to July 2015, in public health establishments that carried out delivery or warehousing of medications (n = 4,938), in 465 municipalites, and the Federal District, in 43'Health Regions'. The results show the existence of at least one management service supporting the health network, and warehousing of medications in all the regions (> 90%)...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444043/challenges-for-ensuring-availability-and-accessibility-toin-health-care-services-under-brazil-s-unified-health-system-sus
#16
Ana Paula Cavalcante de Oliveira, Mariana Gabriel, Mario Roberto Dal Poz, Gilles Dussault
Shortages and imbalances in the distribution of the health workforce, are social and political problems that, along with the socio-economic inequality, reduce the access of the population to the health services. This study aims to understand the challenges of SUS policy-makers and managers to ensure the availability and geographical accessibility to health service providers. The analysis was guided by a framework of the health labour market and health policy interventions. Two main problems have been identified: shortage of doctors and maldistribution of professionals between levels of health care and between geographical areas...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444041/primary-health-care-and-the-coordination-of-care-in-health-regions-managers-and-users-perspective
#17
Aylene Bousquat, Ligia Giovanella, Estela Márcia Saraiva Campos, Patty Fidelis de Almeida, Cleide Lavieri Martins, Paulo Henrique Dos Santos Mota, Maria Helena Magalhães de Mendonça, Maria Guadalupe Medina, Ana Luiza d'Ávila Viana, Márcia Cristina Rodrigues Fausto, Daniel Baffini de Paula
This paper aims to analyze the healthcare coordination by Primary Health Care (PHC), with the backdrop of building a Health Care Network (RAS) in a region in the state of São Paulo, Brazil. We conducted a case study with qualitative and quantitative approaches, proceeding to the triangulation of data between the perception of managers and experience of users. We drew analysis realms and variables from the three pillars of healthcare coordination - informational, clinical and administrative/organizational. Stroke was the tracer event chosen and therapeutic itineraries were conducted with users and questionnaires applied to the managers...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444039/the-health-regionalization-process-from-the-perspective-of-the-transation-cost-theory
#18
Leyla Gomes Sancho, Daniela Savi Geremia, Sulamis Dain, Fabiano Geremia, Cláudio José Silva Leão
This study analyzes the incidence of transaction costs in the regionalization process of health policies in the Brazilian federal system. In this work, regionalized health actions contracted and agreed between federal agencies have assumed a transactional nature. A conceptual theoretical essay of reflective nature was prepared with the purpose of questioning and proposing new approaches to improve the health regionalization process. The main considerations suggest that institutional management tools proposed by the standards and regulations of the Unified Health System have a low potential to reduce transaction costs, especially due to hardships in reconciling common goals among the entities, environment surrounded by uncertainty, asymmetries and incomplete information, bounded rationality and conflict of interest...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444035/regional-governance-in-brazil-s-unified-health-system-a-conceptual-essay
#19
Patrícia Tavares Ribeiro, Oswaldo Yoshimi Tanaka, Jean-Louis Denis
This article is a conceptual essay aimed at supporting analyses of the regionalization processes implemented in Brazil's Unified Health System, from the perspective of regional governance. The authors conducted a literature review in the social sciences, public administration, and critical geography, focusing on the concepts of governance, territorial governance, and regional governance in the debate on development. In dialogue with these contributions to the analysis of recent regulation and implementation of health sector regionalization in Brazil, with special reference to use of the Organizational Contract for Public Action (COAP) in the country's health regions, the article concludes that the research on governance as a modern approach to linking public policies highlights the timeliness of developing methodologies and critical reflection on the relevant national processes in Brazil for future health sector proposals, thereby pointing to a new stage in the improvement of the Unified Health System...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444033/regional-health-inequalities-changes-observed-in-brazil-from-2000-2016
#20
Mariana Vercesi de Albuquerque, Ana Luiza d'Ávila Viana, Luciana Dias de Lima, Maria Paula Ferreira, Edgard Rodrigues Fusaro, Fabíola Lana Iozzi
Advances in reducing poverty and inequalities in the 2000s had a paradoxical effect in Brazil. This article examines how socioeconomic transformations, and the complexity of health services, are expressed in the regions established for planning purposes and the inter-governmental management of the Brazilian Unified Health System. An effort was made to identify and explain differences in the compositions of the 438 existing health regions and their spatial distribution by comparing situations observed in 2016 with those in 2000...
April 2017: Ciência & Saúde Coletiva
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