Yaqian Wei, Yan Chen, Youwei Hong, Jinsheng Chen, Hong-Bo Li, Hanhan Li, Xuewen Yao, Tariq Mehmood, Xinyuan Feng, Xiao-San Luo
Fine particulates in city air significantly impact human health, but the hazardous compositional mechanisms are still unclear. Besides the toxicity of environmental PM2.5 to in vitro human lung epithelial cells (A549), the independent cytotoxicity of PM2.5 -bound water-soluble (WS-PM2.5 ) and water-insoluble (WIS-PM2.5 ) fractions were also compared by cell viability, oxidative stress (reactive oxygen species, ROS), and inflammatory injury (IL-6 and TNF-α). The cytotoxicity of PM2.5 varied significantly by sampling season and place, with degrees greater in winter and spring than in summer and autumn, related to corresponding trend of air PM2...
April 13, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA