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https://www.readbyqxmd.com/read/28944495/functional-morphology-of-the-gonoduct-of-the-viviparous-teleost-poeciliopsis-gracilis-heckel-1848-poeciliidae
#1
Juan Carlos Campuzano-Caballero, Mari Carmen Uribe
Female teleosts do not develop Müllerian ducts; consequently, the ovary of teleosts contains two zones: germinal and gonoduct. The gonoduct lacks germinal cells, but has relevant functions in the reproductive process. We describe the functional morphology of the gonoduct in the viviparous teleost Poeciliopsis gracilis during nongestation and gestation stages. This study tests the hypothesis that the gonoduct functions as a barrier between the germinal zone and the exterior. By providing information about morphology and function of the gonoduct we show that this part of the ovary has an essential role in the reproduction of teleosts...
September 25, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28944331/assessment-of-the-relationship-between-neutrophil-lymphocyte-ratio-and-prognostic-factors-in-non-metastatic-colorectal-cancer
#2
Ersin Borazan, Ahmet Abdulhalik Balık, Zehra Bozdağ, Muhammed Kasım Arık, Alper Aytekin, Latif Yılmaz, Muhsin Elçi, İlyas Başkonuş
OBJECTIVE: Neutrophil-lymphocyte ratio still has a limited clinical use due to many non-cancer factors affecting neutrophils or lymphocytes in the present time. We aimed to evaluate the association between preoperative neutrophil-lymphocyte ratio and poor prognostic factors after curative elective colorectal surgery. MATERIAL AND METHODS: This clinical retrospective study was initiated with 95 patients, who had a curative surgical resection between 2003 and 2013...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944311/integrating-genomic-information-and-signaling-dynamics-for-efficient-cancer-therapy
#3
Jacob Stewart-Ornstein, Galit Lahav
The field of cancer systems biology has made great strides in understanding oncogenic pathway signaling and enumerating mutations involved in oncogenesis. However, application of these datasets to patient stratification, and to the design of personalized therapy, is in its infancy. We review BRAF and BRCA mutant targeted therapy, where patient stratification has had critical, albeit mixed success. We contrast the work on genomic targeted therapy with orthogonal studies on the dynamics of signaling pathways for designing optimal treatment schedules...
February 2017: Current opinion in systems biology
https://www.readbyqxmd.com/read/28944221/optimizing-patient-risk-stratification-for-colonoscopy-screening-and-surveillance-of-colorectal-cancer-the-role-for-linked-data
#4
David B Preen, Iris Lansdorp-Vogelaar, Hooi C Ee, Cameron Platell, Dayna R Cenin, Lakkhina Troeung, Max Bulsara, Peter O'Leary
No abstract text is available yet for this article.
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28944132/rapid-shelf-wide-cooling-response-of-a-stratified-coastal-ocean-to-hurricanes
#5
Greg Seroka, Travis Miles, Yi Xu, Josh Kohut, Oscar Schofield, Scott Glenn
Large uncertainty in the predicted intensity of tropical cyclones (TCs) persists compared to the steadily improving skill in the predicted TC tracks. This intensity uncertainty has its most significant implications in the coastal zone, where TC impacts to populated shorelines are greatest. Recent studies have demonstrated that rapid ahead-of-eye-center cooling of a stratified coastal ocean can have a significant impact on hurricane intensity forecasts. Using observation-validated, high-resolution ocean modeling, the stratified coastal ocean cooling processes observed in two U...
June 2017: Journal of Geophysical Research. Oceans
https://www.readbyqxmd.com/read/28943964/decreased-expression-of-granulocyte-macrophage-colony-stimulating-factor-is-associated-with-adverse-clinical-outcome-in-patients-with-gastric-cancer-undergoing-gastrectomy
#6
Hao Liu, Chao Lin, Zhenbin Shen, Heng Zhang, Hongyong He, He Li, Jing Qin, Xinyu Qin, Jiejie Xu, Yihong Sun
Previous studies have revealed the clinical significance of tumor-associated macrophages (TAMs) in gastric cancer, whereas the role of the cytokines that orchestrate TAM polarization in gastric cancer remains elusive. The present study aimed to evaluate the prognostic value of granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in patients with gastric cancer. Intratumoral GM-CSF expression was investigated by immunohistochemical staining in 408 retrospectively enrolled patients. Kaplan-Meier analysis and Cox regression models were used to evaluate the prognostic value of GM-CSF expression...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943575/comparison-of-the-chads2-cha2ds2-vasc-and-r2chads2-scores-in-japanese-patients-with-non-valvular-paroxysmal-atrial-fibrillation-not-receiving-anticoagulation-therapy
#7
Reisuke Yoshizawa, Takashi Komatsu, Fusanori Kunugita, Mahito Ozawa, Shingen Ohwada, Yoshihiro Satoh, Yoshihiro Morino, Motoyuki Nakamura
Objective It remains unclear whether the CHADS2, CHA2DS2-VASc, or R2CHADS2 score is the most useful for the risk stratification of ischemic stroke/systemic thromboembolism (IS/SE) in Japanese patients with paroxysmal non-valvular atrial fibrillation (PNVAF). Methods and Results We investigated the incidence of IS/SE on the basis of the CHADS2, CHA2DS2-VASc, and R2CHADS2 scores in 332 consecutive PNVAF patients (224 men, mean age: 65±13 years) who had not been administered anticoagulation therapy but who were administered antiarrhythmic drug therapy to maintain sinus rhythm between August 1995 and July 2008 before the 2008 Japanese Circulation Society guideline was issued (mean follow-up period: 53±35 months)...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943269/ramadan-fasting-in-diabetes-exercise-in-problem-solving
#8
Banshi Saboo
AIM: Appropriate management of a diabetic patient with co-morbidities, who is willing to fast during Ramadan. Case presentation A 45 year old male patient with T2DM for 5 years, current A1c of 8.3% and other co-morbidities is currently treated with metformin 500mg BID and glimepiride 2mg. During the pre-Ramadan assessment, glimepiride 2mg was changed to extended release gliclazide 60mg. It resulted in an improvement in his glycemic and microalbuminuria status without any hypoglycemic episodes...
July 29, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28943179/the-effectiveness-of-the-8th-american-joint-committee-on-cancer-tnm-classification-in-the-prognosis-evaluation-of-gastric-cancer-patients-a-comparative-study-between-the-7th-and-8th-editions
#9
Jun Lu, Chao-Hui Zheng, Long-Long Cao, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Chang-Ming Huang
BACKGROUND: The 8th edition of the AJCC TNM staging system for gastric cancer was released in 2016 and included major revisions, especially of stage III. PATIENTS AND METHODS: Data from 3281 patients with GC who underwent R0 resection between December 2006 and November 2014 were reviewed. Of them, 1579 patients with stage III according to the seventh edition were analyzed and the 7th and 8th TNM classifications were compared. RESULTS: The most important tumor stages change observed in stage III GC...
September 13, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28943010/neck-diameter-and-inner-curve-seal-zone-predict-endograft-related-complications-in-highly-angulated-necks-after-endovascular-aneurysm-repair-using-the-aorfix-endograft
#10
Sophie Wang, Caitlin W Hicks, Mahmoud B Malas
OBJECTIVE: Many studies have found that preoperative aneurysm anatomy can determine the postoperative complication rates for endovascular aneurysm repair (EVAR). With continual improvement in endograft technology, patients with challenging anatomy are increasingly able to undergo successful treatment with EVAR. This study aimed to quantify the influence of proximal neck anatomy on contemporary outcomes in a cohort of abdominal aortic aneurysm patients with highly angulated aneurysm necks...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942393/prognostic-value-of-galectin-3-in-adults-with-congenital-heart-disease
#11
Vivan J M Baggen, Annemien E van den Bosch, Jannet A Eindhoven, Myrthe E Menting, Maarten Witsenburg, Judith A A E Cuypers, Eric Boersma, Jolien W Roos-Hesselink
OBJECTIVE: Galectin-3 is an emerging biomarker for risk stratification in patients with heart failure. This study aims to investigate the release of galectin-3 and its association with cardiovascular events in patients with adult congenital heart disease (ACHD). METHODS: In this prospective cohort study, 602 consecutive patients with ACHD who routinely visited the outpatient clinic were enrolled between 2011 and 2013. Galectin-3 was measured in thaw serum by batch analysis...
September 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28942153/the-absence-of-an-association-between-interleukin-1%C3%AE-gene-polymorphisms-and-recurrent-aphthous-stomatitis-ras
#12
Zuzanna Ślebioda, Anna Kowalska, Marta Rozmiarek, Ewa Krawiecka, Elżbieta Szponar, Barbara Dorocka-Bobkowska
OBJECTIVES: Recurrent aphthous stomatitis (RAS) is a chronic, ulcerative disease with a probable polygenic mode of inheritance and complex etiology with a strong immunological background. The aim of the present study was to determine the possible association between two single nucleotide polymorphisms (SNPs) of the IL-1β gene: IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) and RAS susceptibility in a moderately large group of patients. DESIGN: One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach...
September 19, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28942116/low-oocyte-yield-during-ivf-treatment-and-the-risk-of-a-trisomic-pregnancy
#13
Talita Honorato, Annemieke Hoek, Anna-Karina Henningsen, Anja Pinborg, Ojvind Lidegaard, Thea Mooij, Floor van Leeuwen, Jolande Land, Henk Groen, Maaike Haadsma
A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment...
September 6, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28941946/increased-shoulder-arthroscopy-time-is-associated-with-overnight-hospital-stay-and-surgical-site-infection
#14
Venkat Boddapati, Michael C Fu, William W Schairer, Anil S Ranawat, David M Dines, Samuel A Taylor, Joshua S Dines
PURPOSE: The purpose of this study was to characterize the rates of short-term postoperative complications, readmissions, and overnight hospital stays as a function of shoulder arthroscopy procedure time. A secondary aim of this current study was to identify baseline patient risk factors for adverse outcomes. METHODS: This study used the American College of Surgeons National Surgical Quality Improvement Program registry from 2012 to 2015. Shoulder arthroscopy cases were categorized based on operative time, either <45 minutes, between 45 and 90 minutes, or >90 minutes...
September 20, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28941924/risk-stratification-of-equivocal-pi-rads-lesions-in-mp-mri-of-the-prostate
#15
T Ullrich, M Quentin, C Arsov, A K Schmaltz, A Tschischka, N Laqua, A Hiester, D Blondin, R Rabenalt, P Albers, G Antoch, L Schimmöller
PURPOSE: To systematically analyze patients with PI-RADS-3-lesions (called 'equivocal' according to PI-RADS v2) in multiparametric prostate MRI (mp-MRI) and MR-targeted plus systematic transrectal ultrasound-guided (TRUS-GB) biopsies as reference standard. MATERIAL AND METHODS: One hundred and twenty consecutive patients with a PI-RADS overall score of 3 after mp-MRI (T2WI, DWI, DCE-MRI) at 3T and subsequent targeted MRI/US fusion-guided (FUS-GB) plus systematic 12-core TRUS-GB were retrospectively included in this study...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941765/a-review-of-teaching-methods-and-outcomes-of-resident-phacoemulsification
#16
Kevin Kaplowitz, Mohammad Yazdanie, Azin Abazari
Cataract surgery with phacoemulsification is a challenging procedure for surgeons in training to learn to perform safely, efficiently, and effectively. We review the auxiliary learning tools outside the operating room that residency programs have incorporated into their curriculum to improve surgical skills, including wet lab and surgical simulators. We then discuss different methods of teaching cataract surgery in the operating room. Our goal is to define a learning curve for cataract surgery. We demonstrate that complication rates decline significantly after a resident performs an average of 70 cases...
September 20, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28941736/a-prognostic-tool-to-predict-outcomes-in-children-undergoing-the-norwood-operation
#17
Punkaj Gupta, Avishek Chakraborty, Jeffrey M Gossett, Mallikarjuna Rettiganti
OBJECTIVES: To create and validate a prediction model to assess outcomes associated with the Norwood operation. METHODS: The public-use dataset from a multicenter, prospective, randomized single-ventricle reconstruction trial was used to create this novel prediction tool. A Bayesian lasso logistic regression model was used for variable selection. We used a hierarchical framework by representing discrete probability models with continuous latent variables that depended on the risk factors for a particular patient...
August 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28941606/new-developments-in-hypertrophic-cardiomyopathy
#18
REVIEW
Robert M Cooper, Claire E Raphael, Max Liebregts, Nandan S Anavekar, Josef Veselka
Hypertrophic cardiomyopathy is the leading cause of sudden death in young individuals and an important cause of heart failure at any age. In this review we discuss advances in investigation and management of this heterogenous disease. Improved cardiac imaging has allowed us to detail many of the structural abnormalities whereas the use of new techniques, predominantly in cardiac magnetic resonance imaging, has given us a greater insight in to tissue architecture, mechanism of contractile abnormalities, and function...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28940843/comparison-of-transcatheter-aortic-valve-replacement-risk-score-against-currently-accepted-surgical-risk-models-as-predictors-of-30-day-mortality-in-transcatheter-aortic-valve-replacement
#19
Yan Yatsynovich, Himad Khattak, Mohammed Ali, Brian Schwartz, Stella Pak, Tian Chen
OBJECTIVES: Aim of the study was to assess the predictive capability of Transcatheter Aortic Valve Replacement Risk Score (TAVR-RS) in comparison with Society of Thoracic Surgeon-Predicted Risk of Mortality (STS PROM) and European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) on 30-day mortality following TAVR. BACKGROUND: With exponentially increasing use of TAVR, a risk stratification model to accurately predict mortality risks in patients undergoing TAVR is urgently warranted...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28940703/spectroscopic-observation-and-molecular-dynamics-simulation-of-ga-surface-segregation-in-liquid-pd-ga-alloys
#20
Christian Papp, Mathias Grabau, Jannis Erhard, Nicola Taccardi, Sandra Krick Calderon, Peter Wasserscheid, Andreas Görling, Hans-Peter Steinrück
Liquid binary Pd-Ga alloys with low Pd contents of 0.8, 1.8 and 4.7 at.% of Pd were examined as a function of sample temperature in ultra-high vacuum using angle-resolved x-ray photoelectron spectroscopy (XPS). Upon cooling from 750 to 400 K, a pronounced temperature-dependence of the Pd concentration in the liquid phase is observed, which is explained by the transition from the pure liquid phase to a two-phase system, consisting of a solid Ga5Pd phase and a Pd-depleted liquid Pd-Ga alloy. In the liquid Pd-Ga alloy, Pd is always depleted from the topmost interface layer, as deduced from angle-resolved XPS at 0 and 80° emission, independent of temperature and Pd concentration...
September 22, 2017: Chemistry: a European Journal
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