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lactate acid

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https://www.readbyqxmd.com/read/28722155/metabolite-availability-as-a-window-to-view-the-early-embryo-microenvironment-in-vivo
#1
REVIEW
Kailun Hu, Yang Yu
A preimplantation embryo exists independent of blood supply, and relies on energy sources from its in vivo environment (e.g. oviduct and uterine fluid) to sustain its development. The embryos can survive in this aqueous environment because it contains amino acids, proteins, lactate, pyruvate, oxygen, glucose, antioxidants, ions, growth factors, hormones, and phospholipids - albeit the concentration of each component varies by species, stage of the estrous cycle, and anatomical location. The dynamic nature of this environment sustains the early development from the one-cell zygote to blastocyst, and is reciprocally influenced by the embryo at each embryonic stage...
July 19, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28721502/mucin-cross-feeding-of-infant-bifidobacteria-and-eubacterium-hallii
#2
Vera Bunesova, Christophe Lacroix, Clarissa Schwab
Mucus production is initiated before birth and provides mucin glycans to the infant gut microbiota. Bifidobacteria are the major bacterial group in the feces of vaginally delivered and breast milk-fed infants. Among the bifidobacteria, only Bifidobacterium bifidum is able to degrade mucin and to release monosaccharides which can be used by other gut microbes colonizing the infant gut. Eubacterium hallii is an early occurring commensal that produces butyrate and propionate from fermentation metabolites but that cannot degrade complex oligo- and polysaccharides...
July 18, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28719902/serum-hyaluronic-acid-levels-are-altered-in-acute-leukemia-patients-potential-prognostic-implications
#3
Eleni Anagnostopoulou, Chrysanthi Papanastasopoulou, Maria Papastamataki, Antonia Kotsiou, Zoi Topouzoglou, Nikolaos Anagnostopoulos, Nikolaos Sitaras
BACKGROUND: Studies on the serum concentration of hyaluronic acid (HA) in newly diagnosed patients with acute myeloid leukemia (AML), B-acute lymphoblastic leukemia (B-ALL), and mantle-cell lymphoma (MCL) are scarce. In this study, we focused on investigating whether HA could serve as a possible prognostic marker in patients with AML, B-ALL, and MCL. METHODS: The serum concentration of HA was measured in a total of 51 patients with newly diagnosed AML, B-ALL, and MCL...
July 19, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28718839/dose-dependent-prebiotic-effect-of-lactulose-in-a-computer-controlled-in-vitro-model-of-the-human-large-intestine
#4
Melanie K Bothe, Annet J H Maathuis, Susann Bellmann, Jos M B M van der Vossen, Dirk Berressem, Annalena Koehler, Susann Schwejda-Guettes, Barbara Gaigg, Angelika Kuchinka-Koch, John F Stover
Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and Lactobacillus at clinically relevant dosages. The prebiotic effect of subclinical dosages of Lactulose, however, remains to be elucidated. This study analyses changes in the microbiota and their metabolites after a 5 days Lactulose treatment using the TIM-2 system, a computer-controlled model of the proximal large intestine representing a complex, high density, metabolically active, anaerobic microbiota of human origin...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28712262/evaluation-of-efforts-in-untrained-wistar-rats-following-exercise-on-forced-running-wheel-at-maximal-lactate-steady-state
#5
Sajjad Rezaei, Hamid Agha-Alinejad, Mahdieh Molanouri Shamsi, Mahvash Jafari, Fabricio Azevedo Voltarelli, Alireza Naderi, Conrad Earnest
PURPOSE: We aimed to examine the effect of running speed on metabolic responses associated with maximal lactate steady state (MLSS) in rats during forced running wheel (FRW) exercise. METHODS: Forty male adult Wistar rats were divided into seven groups. The blood lactate threshold and peak running speed were determined for an incremental power test group. Five groups participated in constant power tests at intensities 10, 13, 14.5, 16, and 17.5 m/min to determine MLSS and a non-exercise group was chosen as the control...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28711333/b12-deficiency-leading-to-marked-poikilocytosis-versus-true-schistocytosis-a-pernicious-problem
#6
James A Hall, James Mason, Julia Choi, Mark Holguin
Severe vitamin B12 deficiency is caused most commonly by autoimmune atrophic gastritis leading to loss of intrinsic factor. Vitamin B12 deficiency leading to megaloblastic anemia and demyelinating central nervous system disease is well known; however, a rare presentation of B12 deficiency described as pseudothrombotic microangiopathy is not well known. This complication presents with signs of mechanical hemolysis, elevated lactate dehydrogenase (LDH), thrombocytopenia, and a low reticulocyte count, which can be incorrectly diagnosed as thrombotic thrombocytopenic purpura and managed incorrectly...
June 20, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28711266/intravaginal-instillation-of-gonadotropin-releasing-hormone-analogues-with-an-absorption-enhancer-induced-a-surge-of-luteinizing-hormone-in-lactating-dairy-cows
#7
R Wijma, M L Stangaferro, M Masello, M A Elmetwally, G E Granados, F Amovilli, J O Giordano
Our objectives were to evaluate circulating LH concentrations after intravaginal (IVG) instillation of GnRH analogs in lactating dairy cows. In 2 experiments, lactating Holstein cows (experiment 1: n = 32; experiment 2: n = 47) received the experimental treatments 48 h after the first of 2 PGF2α treatments given 12 h apart and 7 d after a modified Ovsynch protocol (GnRH at -7 d, PGF2α at -24 h, PGF2α at -56 h, GnRH at 0 h). In experiment 1, cows were stratified by parity and randomly allocated to receive the following treatments: 2 mL of saline IVG (SAL, n = 6), 100 µg of gonadorelin (Gon) i...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711265/feeding-a-concentrate-rich-in-rapeseed-oil-improves-fatty-acid-composition-and-flavor-in-norwegian-goat-milk
#8
R A Inglingstad, S Skeie, G E Vegarud, T G Devold, Y Chilliard, M Eknæs
Impaired quality due to a high content of free fatty acids (FFA) and off-flavors has caused challenges in the development of Norwegian goat milk products. The present study aimed to examine the effect of lipid-supplemented concentrates on milk fat content, fatty acid composition, FFA, lipoprotein lipase activity, sensory properties, and size of milk fat globules of goat milk. Thirty goats assigned to 3 experimental groups were fed different concentrates from 60 d in milk (DIM) until late lactation (230 DIM)...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711257/seasonal-and-maternal-effects-on-acid-base-l-lactate-electrolyte-and-hematological-status-of-205-dairy-calves-born-to-eutocic-dams
#9
L Kovács, F L Kézér, E Albert, F Ruff, O Szenci
In this study, we used linear mixed models to determine the effects of season, time of sampling relative to birth (factors), duration of the delivery process, duration of maternal grooming, calf body weight (BW) at birth, and time of day (covariates) on values of venous blood gas, acid-base and electrolyte parameters, and l-lactate concentrations in dairy calves born to eutocic dams in summer (SUM, n = 101) and winter (WIN, n = 104). Neonatal vitality was assessed at 0, 1, and 24 h after delivery in a linear scoring system using muscle tone, erection of the head, muscle reflexes, heart rate, and sucking drive as criteria...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711252/ethyl-cellulose-rumen-protected-methionine-enhances-performance-during-the-periparturient-period-and-early-lactation-in-holstein-dairy-cows
#10
F Batistel, J M Arroyo, A Bellingeri, L Wang, B Saremi, C Parys, E Trevisi, F C Cardoso, J J Loor
The onset of lactation in dairy cows is characterized by severe negative energy and protein balance. Increasing Met availability during this time may improve milk production, hepatic lipid metabolism, and immune function. The aim of this study was to evaluate the effect of feeding ethyl-cellulose rumen-protected methionine (RPM; Mepron, Evonik Nutrition and Care GmbH, Hanau-Wolfgang, Germany) on the performance of dairy cows during prepartum and early-lactation periods. Sixty multiparous Holstein cows were used in a block design and assigned to either a control or an ethyl-cellulose RPM diet...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711247/ratio-of-dietary-rumen-degradable-protein-to-rumen-undegradable-protein-affects-nitrogen-partitioning-but-does-not-affect-the-bovine-milk-proteome-produced-by-mid-lactation-holstein-dairy-cows
#11
R Tacoma, J Fields, D B Ebenstein, Y-W Lam, S L Greenwood
Little is known about the bovine milk proteome or whether it can be affected by diet. The objective of this study was to determine if the dietary rumen degradable protein (RDP):rumen undegradable protein (RUP) ratio could alter the bovine milk proteome. Six Holstein cows (parity: 2.5 ± 0.8) in mid lactation were blocked by days in milk (80 ± 43 d in milk) and milk yield (57.5 ± 6.0 kg) and randomly assigned to treatment groups. The experiment was conducted as a double-crossover design consisting of three 21-d periods...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28711245/feeding-of-palm-oil-fatty-acids-or-rapeseed-oil-throughout-lactation-effects-on-energy-status-body-composition-and-milk-production-in-norwegian-dairy-goats
#12
M Eknæs, Y Chilliard, K Hove, R A Inglingstad, L Bernard, H Volden
The objective of this experiment was to examine how supplements of rapeseed oil or palm oil fatty acids would affect milk production and composition, body lipid stores, and energy balance in 30 multiparous goats of Norwegian dairy goat breed. The experiment lasted 230 d, with 1 to 120 d in milk (DIM) for indoor feeding (P1), 120 to 200 DIM for mountain grazing (P2), and 200 to 230 DIM for indoor feeding (P3). Grass silage was fed according to appetite during indoor feeding periods. After an adjustment period (1-60 DIM) when the control diet was given to the goats, the animals were subdivided into 3 groups of 10 goats...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28710988/intestinal-fatty-acid-binding-protein-level-as-a-predictor-of-28-day-mortality-and-bowel-ischemia-in-patients-with-septic-shock-a-preliminary-study
#13
Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Kyoko Okada, Haruka Inoue, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Shuhei Matsumoto, Tetsuya Hara
PURPOSE: We sought to evaluate the levels of intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, as a predictor of 28-day mortality and bowel ischemia in septic shock patients. MATERIAL AND METHODS: In this preliminary prospective observational study, 57 adult septic shock patients under mechanical ventilation were enrolled. Serum I-FABP levels and prognostic biomarkers were recorded upon intensive care unit (ICU) admission. RESULTS: The overall 28-day mortality rate of participants was 23% (13/57)...
July 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28709157/hypotensive-resuscitation-with-hypertonic-saline-dextran-improves-survival-in-a-rat-model-of-hemorrhagic-shock-at-high-altitude
#14
Jingxiang Zhao, Guoxing You, Bo Wang, Zhenwei Sun, Zhen Wang, Sha Xia, Lian Zhao, Hong Zhou
OBJECTIVE: To compare the efficacy of hypotensive resuscitation with hypertonic saline dextran 70 (HSD) and lactated Ringer (LR) solutions in a rat model of hemorrhagic shock at a simulated altitude of 4,000 m. METHODS: Anesthetized rats were bled to maintain their mean arterial pressure (MAP) at 45 mm Hg for 1 h. The distal quarter of the tail was then amputated to allow free blood loss; rats were simultaneously resuscitated with 4 mL kg HSD (HSD group, n = 10) or 4 mL kg LR (LR group, n = 10), followed by hypotensive resuscitation with LR to maintain MAP at 55 to 60 mm Hg for 1 h...
August 2017: Shock
https://www.readbyqxmd.com/read/28709040/low-concentrations-of-bisphenol-a-promote-human-ovarian-cancer-cell-proliferation-and-glycolysis-based-metabolism-through-the-estrogen-receptor-%C3%AE-pathway
#15
Xiao-Yu Shi, Zhe Wang, Liyu Liu, Li-Min Feng, Nan Li, Sijin Liu, Hui Gao
Bisphenol A (BPA) is one of the most prevalent chemicals in many products used on a daily basis, making human exposure to it incredibly pervasive and raising concerns about its health consequences. One area of research focus has been the role of BPA exposure in promoting the development of ovarian cancer; however, the doses used in most of previous studies are relatively high and most likely exceed physiologically relevant levels. At the same time, few studies have described potential mechanisms underlying the link between BPA and increased cancer risk...
July 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28707864/oxidative-stress-antioxidants-and-lipid-profile-in-the-serum-and-saliva-of-individuals-with-coronary-heart-disease-is-there-a-link-with-periodontal-health
#16
Natheer H Al-Rawi, Alaa M Shahid
BACKGROUND: Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. The aim of this study was to find the relationship between the salivary lipid profile, lipid peroxidation and antioxidants and the periodontal health status of patients with acute coronary heart disease. METHODS: Forty s who had experienced a recent attack of angina pectoris or myocardial infarction and another 40 noncardiac patients matched for age, sex and residence (control) were recruited...
July 12, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28707516/anaerobic-decolorization-and-detoxification-of-cationic-red-x-grl-by-shewanella-oneidensis-mr-1
#17
Qian Li, Xiao-Li Feng, Ting-Ting Li, Xue-Rong Lu, Qiu-Yue Liu, Xue Han, Yu-Jie Feng, Zhao-Ying Liu, Xi-Jia Zhang, Xiang Xiao
The ability of a electrochemically active bacterium, Shewanella oneidensis MR-1, to decolorize azo dye cationic red X-GRL (X-GRL) was investigated. S. oneidensis MR-1 showed a high decolorization capability for X-GRL under anaerobic conditions. The Mtr respiratory pathway was proved to be involved in the extracellular decolorization of X-GRL. The decolorization efficiency of S. oneidensis MR-1 was significantly inhibited when initial X-GRL concentration was over 200 mg L(-1). Increasing the inoculum volume of S...
July 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28706733/the-effect-of-characteristics-of-proteins-fed-during-gestation-and-lactation-on-development-of-metabolic-syndrome-in-dams-and-male-offspring-of-wistar-rats
#18
A Jahan-Mihan, C A Labyak, A Y Arikawa
OBJECTIVE: The objective of the study is to examine the role of characteristics of proteins in maternal and weaning diets on risk of metabolic syndrome in male offspring. METHODS: Pregnant Wistar rats were allocated to two groups (n = 12) and were fed the AIN-93G diets based on either intact protein-based diet (IPD) or mixed amino acid-based diet (AAD) from day 3 of gestation throughout gestation and lactation. Male offspring were weaned to either an IPD or AAD diet for 18 weeks...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28706006/integration-of-flux-measurements-to-resolve-changes-in-anabolic-and-catabolic-metabolism-in-cardiac-myocytes
#19
Andrew A Gibb, Pawel K Lorkiewicz, Yu-Ting Zheng, Xiang Zhang, Aruni Bhatnagar, Steven P Jones, Bradford G Hill
Although ancillary pathways of glucose metabolism are critical for synthesizing cellular building blocks and modulating stress responses, how they are regulated remains unclear.  In this study, we used radiometric glycolysis assays, [(13)C6]-glucose isotope tracing, and extracellular flux analysis to understand how phosphofructokinase (PFK)-mediated changes in glycolysis regulate glucose carbon partitioning into catabolic and anabolic pathways. Expression of kinase-deficient or phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in rat neonatal cardiomyocytes coordinately regulated glycolytic rate and lactate production...
July 13, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28704613/-e-2-benzylidene-4-phenyl-1-3-diselenole-an-antioxidant-compound-protects-rats-against-thioacetamide-induced-acute-hepatotoxicity
#20
Angélica S Reis, Mikaela Pinz, Cristiani F Bortolatto, Cristiano Ricardo Jesse, Lucielli Savegnago, Silvane Souza Roman, Cristiane Luchese, Ethel A Wilhelm
The aim of this study was to investigate whether (E)-2-benzylidene-4-phenyl-1,3-diselenole (BPD) protects against hepatotoxicity induced by thioacetamide (TAA). On the first day of treatment, the animals received BPD (10 or 50 mg/kg). On the second day, the rats received a single intraperitoneal injection of TAA (400 mg/kg). Twenty-four hours after TAA administration, biochemical determinations and liver histological analysis were carried out. BPD (50 mg/kg) reduced plasma aspartate and alanine aminotransferases, alkaline phosphatase and lactate dehydrogenase activities increased by TAA exposure...
July 13, 2017: Canadian Journal of Physiology and Pharmacology
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