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https://www.readbyqxmd.com/read/27898686/gut-homing-cd4-and-cd8-t-cell-frequencies-in-hiv-infected-individuals-on-antiretroviral-treatment
#1
Olivia Briceño, Sandra Pinto-Cardoso, Nataly Rodríguez-Bernabe, Akio Murakami-Ogasawara, Gustavo Reyes-Terán
The depletion of mucosal CD4+ T-cells occurs early in HIV infection and despite years on antiretroviral treatment (ART), this population never reconstitutes to pre-HIV infection levels. In an effort to understand the effect of ART initiation and different ART regimens on the reconstitution of mucosal T cells within the gut associated lymphoid tissue (GALT), we quantified the frequency of CD4+ and CD8+ T cells expressing the gut homing receptors CCR9 and β7 in peripheral blood (PB) of HIV infected individuals naive to ART and treated individuals on both short-term (less than a year) and long-term ART (more than 2 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27895020/a-naturally-occurring-snp-in-plasmid-pb1000-produces-a-reversible-increase-in-antibiotic-resistance
#2
Alfonso Santos-Lopez, Cristina Bernabe-Balas, Manuel Ares-Arroyo, Rafael Ortega-Huedo, Andreas Hoefer, Alvaro San Millan, Bruno Gonzalez-Zorn
ColE1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in Pasteurellaceae. In this study we describe how a natural single nucleotide polymorphism (SNP) near the origin of replication of the ColE1-type plasmid pB1000 found in a Pasteurella multocida clinical isolate, generates two independent plasmid variants able to coexist in the same cell simultaneously. Using Haemophilus influenzae Rd strain as a model system, we combined antibiotic susceptibility tests, quantitative PCRs, competition assays and experimental evolution to characterize the consequences of the coexistence of the pB1000 plasmid variants...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27887913/prospective-assessment-of-cosmesis-before-and-after-genital-surgery
#3
N J Nokoff, B Palmer, A J Mullins, C E Aston, P Austin, L Baskin, K Bernabé, Y-M Chan, E Y Cheng, D A Diamond, A Fried, D Frimberger, D Galan, L Gonzalez, S Greenfield, T Kolon, B Kropp, Y Lakshmanan, S Meyer, T Meyer, L L Mullins, A Paradis, D Poppas, P Reddy, M Schulte, K J Scott Reyes, J M Swartz, C Wolfe-Christensen, E Yerkes, A B Wisniewski
INTRODUCTION: Little data exist about the surgical interventions taking place for children with disorders of sex development (DSD). Most studies that have evaluated cosmetic outcomes after genitoplasty have included retrospective ratings by a physician at a single center. OBJECTIVE: The present study aimed to: 1) describe frequency of sex assignment, and types of surgery performed in a cohort of patients with moderate-to-severe genital ambiguity; and 2) prospectively determine cosmesis ratings by parents and surgeons before and after genital surgery...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887794/retinoschisis-and-neurosensory-detachment-in-advanced-focal-glaucoma
#4
E Arranz-Márquez, E Jarrín Hernández, A Pastor, J García Gil de Bernabé
CLINICAL CASE: A 71-year-old woman with normotensive primary open-angle glaucoma presented with an asymptomatic temporal peripapillary retinoschisis, associated with serous retinal detachment in the eye with the more advanced glaucoma. It was located at the inferior pole of the optic disc, in the proximity of a glaucomatous focal disc defect. DISCUSSION: Although congenital optic pits are strongly related with juxta-papillary retinoschisis, retinoschisis can also arise from acquired defects in the proximity of glaucomatous optic discs...
November 22, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27886793/innovative-approaches-to-hypertension-control-in-low-and-middle-income-countries
#5
REVIEW
Rajesh Vedanthan, Antonio Bernabe-Ortiz, Omarys I Herasme, Rohina Joshi, Patricio Lopez-Jaramillo, Amanda G Thrift, Jacqui Webster, Ruth Webster, Karen Yeates, Joyce Gyamfi, Merina Ieremia, Claire Johnson, Jemima H Kamano, Maria Lazo-Porras, Felix Limbani, Peter Liu, Tara McCready, J Jaime Miranda, Sailesh Mohan, Olugbenga Ogedegbe, Brian Oldenburg, Bruce Ovbiagele, Mayowa Owolabi, David Peiris, Vilarmina Ponce-Lucero, Devarsetty Praveen, Arti Pillay, Jon-David Schwalm, Sheldon W Tobe, Kathy Trieu, Khalid Yusoff, Valentin Fuster
Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Treatment and control rates are very low in low- and middle-income countries. There is an urgent need to address this problem. The Global Alliance for Chronic Diseases sponsored research projects focus on controlling hypertension, including community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. This paper reviews the rationale for each approach and summarizes the experience of some of the research teams...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27884719/systematic-review-and-meta-analysis-of-randomised-controlled-trials-on-the-effectiveness-of-school-based-dental-screening-versus-no-screening-on-improving-oral-health-in-children
#6
REVIEW
Easter Joury, Eduardo Bernabe, Wael Sabbah, Kamal Nakhleh, Kurinchi Gurusamy
OBJECTIVES: The current study aimed to evaluate the effectiveness of school-based dental screening versus no screening on improving oral health in children aged 3-18 years by a systematic review and meta-analysis of randomised controlled trials. SOURCES AND STUDY SELECTION: Three sets of independent reviewers searched MEDLINE, EMBASE, Web of Science and other sources through April 2016 to identify published and nonpublished studies without language restrictions and extracted data...
November 22, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27866751/weight-loss-after-bariatric-surgery-and-periodontal-changes-a-12-month-prospective-study
#7
Silvia Helena de Carvalho Sales-Peres, Matheus de Carvalho Sales-Peres, Reginaldo Ceneviva, Eduardo Bernabé
BACKGROUND: Several longitudinal studies have explored the association of obesity and weight gain with periodontal disease. However, the effect of weight loss on periodontal tissues remains unclear. OBJECTIVE: To explore whether weight loss after bariatric surgery was associated with changes in periodontal measures over 12 months. SETTING: Two public hospitals in São Paulo, Brazil. METHODS: We used data from 110 morbidly obese patients (body mass index [BMI]>40 kg/m(2) or≥35 kg/m(2) with co-morbid conditions) who underwent bariatric surgery between April 2011 and March 2013...
August 5, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27856311/timing-of-dietary-acid-intake-and-erosive-tooth-wear-a-case-control-study
#8
Saoirse O'Toole, Eduardo Bernabé, Rebecca Moazzez, David Bartlett
OBJECTIVES: There is a lack of clinical data on the impact of timing of dietary acid intake and toothbrush abrasion when attempting to control erosive tooth wear progression. The aim of this study was to estimate the association of theoretical causative factors with erosive tooth wear to inform evidence-based guidelines. METHODS: Using case-control study design, 300 participants with dietary erosive tooth wear and 300 age-matched controls were recruited from the restorative clinics of King's College London Dental Institute...
November 14, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27848191/plagiarism-cheating-and-research-integrity-case-studies-from-a-masters-program-in-peru
#9
Andres M Carnero, Percy Mayta-Tristan, Kelika A Konda, Edward Mezones-Holguin, Antonio Bernabe-Ortiz, German F Alvarado, Carlos Canelo-Aybar, Jorge L Maguiña, Eddy R Segura, Antonio M Quispe, Edward S Smith, Angela M Bayer, Andres G Lescano
Plagiarism is a serious, yet widespread type of research misconduct, and is often neglected in developing countries. Despite its far-reaching implications, plagiarism is poorly acknowledged and discussed in the academic setting, and insufficient evidence exists in Latin America and developing countries to inform the development of preventive strategies. In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes (2011-2014) of an Epidemiology Masters program in Lima, Peru, and describes the implementation and outcomes of a multifaceted, "zero-tolerance" policy aimed at introducing research integrity...
November 15, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27834298/birth-weight-breastfeeding-maternal-smoking-and-caries-trajectories
#10
E Bernabé, H MacRitchie, C Longbottom, N B Pitts, W Sabbah
Evidence for the effects of low birth weight, breastfeeding and maternal smoking on childhood caries is mainly cross-sectional. We examined the association of these 3 putative early life factors with caries increment over a 4-y period among young children. We used data from a 4-y longitudinal caries-risk assessment study carried out among Scottish children. Early life factors were measured when children were aged 1 y (baseline). Caries assessment was repeated annually from ages 1 to 4, and the number of decayed, missing and filled primary tooth surfaces (dmfs) were used as a repeated outcome measure...
November 9, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27806350/enteral-docosahexaenoic-acid-reduces-analgesic-administration-in-neonates-undergoing-cardiovascular-surgery
#11
Mariela Bernabe-Garcia, Mardia López-Alarcon, Alfredo Salgado-Sosa, Raul Villegas-Silva, Jorge Maldonado-Hernandez, Maricela Rodríguez-Cruz, Rodolfo Rivas-Ruiz, Luis Chavez-Sanchez, Francisco A Blanco-Favela, Javier Mancilla-Ramirez, Virginia Gordillo-Alvarez, Olivia Madrigal-Muñiz
BACKGROUND: Neonates undergoing surgery require analgesic medication to ameliorate acute pain. These medications produce negative side effects. Docosahexaenoic acid (DHA) has an antinociceptive effect in animals, but this has not been evaluated in human neonates. We evaluated the DHA effect on cumulative dose and duration of analgesics administered to neonates undergoing cardiovascular surgery. METHODS: A secondary analysis was performed with data from a clinical trial, in which enteral DHA was administered perioperatively compared with sunflower oil (SO)...
2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27803023/erratum-amelioration-of-diabetes-by-protein-s-diabetes-2016-65-1940-1951
#12
Taro Yasuma, Yutaka Yano, Corina N D'Alessandro-Gabazza, Masaaki Toda, Paloma Gil-Bernabe, Tetsu Kobayashi, Kota Nishihama, Josephine A Hinneh, Rumi Mifuji-Moroka, Ziaurahman Roeen, John Morser, Isaac Cann, Iwasa Motoh, Yoshiyuki Takei, Esteban C Gabazza
No abstract text is available yet for this article.
November 1, 2016: Diabetes
https://www.readbyqxmd.com/read/27785006/socioeconomic-status-and-copd-among-low-and-middle-income-countries
#13
Matthew Grigsby, Trishul Siddharthan, Muhammad Ah Chowdhury, Ali Siddiquee, Adolfo Rubinstein, Edgardo Sobrino, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, William Checkley
BACKGROUND: Socioeconomic status (SES) is a strong social determinant of health. There remains a limited understanding of the association between SES and COPD prevalence among low- and middle-income countries where the majority of COPD-related morbidity and mortality occurs. We examined the association between SES and COPD prevalence using data collected in Argentina, Bangladesh, Chile, Peru, and Uruguay. METHODS: We compiled lung function, demographic, and SES data from three population-based studies for 11,042 participants aged 35-95 years...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27779757/analysis-of-cell-free-fetal-dna-in-maternal-blood-for-detection-of-trisomy-21-18-and-13-in-a-general-pregnant-population-and-in-a-high-risk-population-a-systematic-review-and-meta-analysis
#14
Erik Iwarsson, Bo Jacobsson, Jessica Dagerhamn, Thomas Davidson, Eduardo Bernabé, Marianne Heibert Arnlind
INTRODUCTION: To review the performance of non-invasive prenatal testing (NIPT) for detection of trisomy 21, 18 and 13 (T21, T18 and T13) in a general pregnant population as well as to update the data on high-risk pregnancies. MATERIAL AND METHODS: Systematic Review and Meta-Analysis. PubMed, Embase and the Cochrane Library were searched. Methodological quality was rated using QUADAS and scientific evidence using GRADE. Summary measures of diagnostic accuracy were calculated using a bivariate random-effects model...
October 25, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27773540/secondary-cv-prevention-in-south-america-in-a-community-setting-the-pure-study
#15
Alvaro Avezum, Gustavo B F Oliveira, Fernando Lanas, Patricio Lopez-Jaramillo, Rafael Diaz, J Jaime Miranda, Pamela Seron, Paul A Camacho-Lopez, Andres Orlandini, Antonio Bernabe-Ortiz, Antônio Cordeiro Mattos, Shofiqul Islam, Sumathy Rangarajan, Koon Teo, Salim Yusuf
BACKGROUND: Despite the availability of evidence-based therapies, there is no information on the use of medications for the secondary prevention of cardiovascular disease in urban and rural community settings in South America. OBJECTIVES: This study sought to assess the use, and its predictors, of effective secondary prevention therapies in individuals with a history of coronary heart disease (CHD) or stroke. METHODS: In the PURE (Prospective Urban Rural Epidemiological) study, we enrolled 24,713 individuals from South America ages 35 to 70 years from 97 rural and urban communities in Argentina, Brazil, Chile, and Colombia...
October 20, 2016: Global Heart
https://www.readbyqxmd.com/read/27755424/extra-gingival-pyogenic-granuloma-displacing-teeth
#16
Ketelin Juliane Dal Prá, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Marcelo Macedo Crivelini, Kellen Cristine Tjioe
Pyogenic granuloma is a common cause of growth of soft tissue in the oral cavity, especially in the gingiva. It is mainly associated with local and chronic irritants besides hormonal changes during pregnancy. Here, the authors present an unusual patient of an extra-gingival pyogenic granuloma with large dimensions and displacing teeth arising in a male patient. This is an interesting patient to be reported due to its exacerbated and atypical clinical features.
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755423/pemphigus-vulgaris-how-to-perform-an-oral-biopsy-properly
#17
Aneliza de Fatima Moraes da Silva, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Renata Callestini, Kellen Cristine Tjioe
Oral biopsy of vesiculobullous diseases such as pemphigus vulgaris often raises questions due to some particularities involving this procedure. The adequate selection of the area to be biopsied defines if the final diagnosis will be reached, being the Achiles heel of the proper management of the patient. Here, the authors report a case of a woman who sought for treatment of generalized oral blisters and ulcers that caused severe pain. She had undergone a previous biopsy by other professionals that was inconclusive...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27736711/atmospheric-fate-of-hydrofluoroolefins-cxf2x-1chch2-x%C3%A2-%C3%A2-1-2-3-4-and-6-kinetics-with-cl-atoms-and-products
#18
Bernabé Ballesteros, Elena Jiménez, Alberto Moreno, Amparo Soto, María Antiñolo, José Albaladejo
Rate coefficients for the gas-phase reactions of CxF2x+1CHCH2 (x = 1, 2, 3, 4 and 6) with Cl atoms were determined at (298 ± 2) K and (710 ± 5) Torr of air using a relative rate technique. Two experimental setups with simulation chambers were employed with Fourier Transform Infrared (FTIR) spectroscopy and Gas Chromatography coupled to Mass Spectrometry (GC-MS) as detection techniques. The Cl-rate coefficients obtained were (in 10(-10) cm(3) molecule(-1) s(-1)): (0.85 ± 0.11) for CF3CHCH2, (1...
October 10, 2016: Chemosphere
https://www.readbyqxmd.com/read/27716922/coalescing-red-algae-exhibit-non-invasive-reversible-chimerism
#19
Bernabé Santelices, Alejandra V González, Jessica Beltrán, Verónica Flores
Chimerism is produced by the somatic fusion of two or more genetically distinct conspecific individuals. In animals, the main cost of fusion is competition between genetically different cell lineages and the probability of original cell-line replacement by more competitive invasive lines, which limits its natural frequency (3-5%). In red and brown seaweeds, chimerism is widespread (27-53%), seemingly without the negative outcomes described for animals. The rigidity of cell walls in macroalgae prevents cell motility and invasions...
October 7, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27710820/geographical-variation-in-the-progression-of-type-2-diabetes-in-peru-the-cronicas-cohort-study
#20
Antonio Bernabé-Ortiz, Rodrigo M Carrillo-Larco, Robert H Gilman, Catherine H Miele, William Checkley, Jonathan C Wells, Liam Smeeth, J Jaime Miranda
BACKGROUND: The study aims were to estimate the incidence and risk factors for T2D in four settings with different degree of urbanization and altitude in Peru. METHODS: Prospective cohort study conducted in urban, semi-urban, and rural areas in Peru. An age- and sex-stratified random sample of participants was taken from the most updated census. T2D was defined as fasting blood glucose ⩾7.0mmol/L or taking anti-diabetes medication. Exposures were divided into two groups: geographical variables (urbanization and altitude), and modifiable risk factors...
September 21, 2016: Diabetes Research and Clinical Practice
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