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https://www.readbyqxmd.com/read/29326111/low-prevalence-of-ideal-cardiovascular-health-in-peru
#1
Catherine P Benziger, José Alfredo Zavala-Loayza, Antonio Bernabe-Ortiz, Robert H Gilman, William Checkley, Liam Smeeth, German Malaga, Juan Jaime Miranda
BACKGROUND: The prevalence of and factors associated with ideal cardiovascular health (ICH) by sociodemographic characteristics in Peru is not well known. METHODS: The American Heart Association's ICH score comprised 3 ideal health factors (blood pressure, untreated total cholesterol and glucose) and 4 ideal health behaviours (smoking, body mass index, high physical activity and fruit and vegetable consumption). ICH was having 5 to 7 of the ideal health metrics...
January 11, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29323928/association-between-household-air-pollution-exposure-and-chronic-obstructive-pulmonary-disease-outcomes-in-13-low-and-middle-income-country-settings
#2
Trishul Siddharthan, Matthew R Grigsby, Dina Goodman, Muhammad Chowdhury, Adolfo Rubenstein, Vilma Irazola, Laura Gutierrez, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert Jones, Frederick van Gemert, Robert A Wise, William Checkley
RATIONALE: Forty percent of households worldwide burn biomass fuels for energy, which may be most the important contributor to household air pollution. OBJECTIVE: To examine the association between household air pollution exposure and COPD outcomes in 13 resource-poor settings. METHODS: We analyzed data from 12,396 adult participants living in 13 resource-poor, population-based settings. Household air pollution exposure was defined as using biomass materials as the primary fuel source in the home...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29323406/type-and-timing-of-dietary-acid-intake-and-tooth-wear-among-american-adults
#3
Lynn H Al-Zwaylif, Saoirse O'Toole, Eduardo Bernabé
OBJECTIVES: To explore the interrelationship between type and timing of dietary acid intake and tooth wear among American adults. METHODS: This study used data from 3,586 adults, aged 18 years and older, who participated in the National Health and Nutrition Examination Survey (NHANES) 2003-04. Information on four types of acidic food and beverages (fruits, fruit juices, alcoholic drinks, and soft drinks) and timing of consumption (meals versus snacks, defined according to percentage of total energy intake, self-reported eating occasion, and time of day) was extracted from two 24-hour dietary recalls...
January 11, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29321169/the-actin-mrtf-srf-transcriptional-circuit-controls-tubulin-acetylation-via-%C3%AE-tat1-gene-expression
#4
Jaime Fernández-Barrera, Miguel Bernabé-Rubio, Javier Casares-Arias, Laura Rangel, Laura Fernández-Martín, Isabel Correas, Miguel A Alonso
The role of formins in microtubules is not well understood. In this study, we have investigated the mechanism by which INF2, a formin mutated in degenerative renal and neurological hereditary disorders, controls microtubule acetylation. We found that silencing of INF2 in epithelial RPE-1 cells produced a dramatic drop in tubulin acetylation, increased the G-actin/F-actin ratio, and impaired myocardin-related transcription factor (MRTF)/serum response factor (SRF)-dependent transcription, which is known to be repressed by increased levels of G-actin...
January 10, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29283130/color-doppler-imaging-of-the-retrobulbar-circulation-and-plasmatic-biomarkers-of-vascular-risk-in-age-related-macular-degeneration-a-pilot-study
#5
Fermin Rodrigo, José María Ruiz-Moreno, Juan Bernabé García, María Eugenia Torregrosa, José Vicente Segura, David P Piñero
PURPOSE: To evaluate preliminarily and compare the level of plasmatic biomarkers of vascular risk in patients with and without exudative age-related macular degeneration (ARMD) and to relate it to vascular resistance alterations in the ophthalmic artery (OA), central retinal artery (CRA), posterior temporal ciliary artery (PTCA), and posterior nasal ciliary artery (PNCA). METHODS: Color Doppler imaging of the OA, CRA, PTCA, and PNCA was performed in 30 eyes of 30 cataract patients (control group) as well as in 30 eyes of 30 patients with naive exudative ARMD (study group), measuring the peak systolic velocity, end-diastolic velocity (EDV), and Pourcelot resistive index (RI)...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29276619/association-between-sleep-difficulties-as-well-as-duration-and-hypertension-is-bmi-a-mediator
#6
R M Carrillo-Larco, A Bernabe-Ortiz, K A Sacksteder, F Diez-Canseco, M K Cárdenas, R H Gilman, J J Miranda
Sleep difficulties and short sleep duration have been associated with hypertension. Though body mass index (BMI) may be a mediator variable, the mediation effect has not been defined. We aimed to assess the association between sleep duration and sleep difficulties with hypertension, to determine if BMI is a mediator variable, and to quantify the mediation effect. We conducted a mediation analysis and calculated prevalence ratios with 95% confidence intervals. The exposure variables were sleep duration and sleep difficulties, and the outcome was hypertension...
2017: Glob Health Epidemiol Genom
https://www.readbyqxmd.com/read/29220367/periodontitis-is-associated-with-significant-hepatic-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#7
William Alazawi, Eduardo Bernabe, David Tai, Tomasz Janicki, Polychronis Kemos, Salma Samsuddin, Wing-Kin Syn, David Gillam, Wendy Turner
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) has a bidirectional association with metabolic syndrome. It affects up to 30% of the general population, 70% of individuals with diabetes and 90% with obesity. The main histological hallmark of progressive NAFLD is fibrosis. There is a bidirectional epidemiological link between periodontitis and metabolic syndrome. NAFLD, periodontitis and diabetes share common risk factors, are characterised by inflammation and associated with changes in commensal bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/29193896/in-utero-ultrasound-diagnosis-of-corpus-callosum-agenesis-leading-to-the-identification-of-orofaciodigital-type-1-syndrome-in-female-fetuses
#8
Caroline Alby, Lucile Boutaud, Maryse Bonnière, Sophie Collardeau-Frachon, Laurent Guibaud, Estelle Lopez, Ange-Line Bruel, Bernard Aral, Pascale Sonigo, Philippe Roth, Claude Vibert-Guigue, Vanina Castaigne, Bruno Carbonne, Nicole Joyé, Laurence Faivre, Marie-Pierre Cordier, Antoinette Bernabe Gelot, Maurizio Clementi, Isabella Mammi, Michel Vekemans, Féréchté Razavi, Marie Gonzales, Christel Thauvin-Robinet, Tania Attié-Bitach
BACKGROUND: OFD1 syndrome is a rare ciliopathy inherited on a dominant X-linked mode, typically lethal in males in the first or second trimester of pregnancy. It is characterized by oral cavity and digital anomalies possibly associated with cerebral and renal signs. Its prevalence is between 1/250,000 and 1/50,000 births. It is due to heterozygous mutations of OFD1 and mutations are often de novo (75%). Familial forms show highly variable phenotypic expression. OFD1 encodes a protein involved in centriole growth, distal appendix formation, and ciliogenesis...
November 28, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29187155/risk-score-for-first-screening-of-prevalent-undiagnosed-chronic-kidney-disease-in-peru-the-cronicas-ckd-risk-score
#9
Rodrigo M Carrillo-Larco, J Jaime Miranda, Robert H Gilman, Josefina Medina-Lezama, Julio A Chirinos-Pacheco, Paola V Muñoz-Retamozo, Liam Smeeth, William Checkley, Antonio Bernabe-Ortiz
BACKGROUND: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in limited-resources settings where laboratory facilities are scarce. This study aimed to develop a risk score for prevalent undiagnosed CKD using data from four settings in Peru: a complete risk score including all associated risk factors and another excluding laboratory-based variables...
November 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29178189/toothbrushing-behaviour-and-periodontal-pocketing-an-11-year-longitudinal-study
#10
Shriraksha Joshi, Anna L Suominen, Matti Knuuttila, Eduardo Bernabé
AIM: To explore the association between toothbrushing behaviour and change in periodontal pocketing among adults. METHODS: We pooled data from 1025 adults, aged 30-89 years, who participated in two national surveys in Finland (Health 2000 and Health 2011, BRIF8901) and reported their toothbrushing frequency. A cumulative measure of regular toothbrushing was created by counting the number of times participants reported brushing twice or more daily across the two surveys (ranging from 0 to 2)...
November 27, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29150404/stress-hormones-concentrations-in-the-normal-microenvironment-predict-risk-for-chemically-induced-cancer-in-rats
#11
Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé
Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant predictive value for chemically induced cancer occurrence. Male Wistar rats were submitted to a tongue biopsy for measuring not-stress induced levels of norepinephrine, corticosterone, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) in the tissue before carcinogenic induction...
November 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29127427/amniotic-membrane-promotes-focal-adhesion-remodeling-to-stimulate-cell-migration
#12
Ángel Bernabé-García, Sergio Liarte, Jose M Moraleda, Gregorio Castellanos, Francisco J Nicolás
During wound healing, the migration of keratinocytes onto newly restored extracellular matrix aims to reestablish continuity of the epidermis. The application of amniotic membrane (AM) to chronic, deep traumatic, non-healing wounds has proven successful at stimulating re-epithelialization. When applied on epithelial cell cultures, AM activates extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases 1/2 (JNK1/2), with the overexpression and phosphorylation of c-Jun along the wound edge...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097121/does-tooth-loss-affect-dietary-intake-and-nutritional-status-a-systematic-review-of-longitudinal-studies
#13
REVIEW
Piyada Gaewkhiew, Wael Sabbah, Eduardo Bernabé
INTRODUCTION/OBJECTIVE: A systematic review was conducted to explore whether tooth loss affects dietary intake and nutritional status among adults. DATA: Longitudinal studies of population-based or clinical samples of adults exploring the effect of tooth loss on food/dietary/nutrient intake and/or nutritional status were included for consideration. The risk of bias was assessed using the Newcastle-Ottawa Scale for cohort studies. SOURCES: A search strategy was designed to find published studies on MEDLINE, EMBASE and LILACS up to March 2017...
October 31, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29084286/ezscan-for-undiagnosed-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#14
Antonio Bernabe-Ortiz, Andrea Ruiz-Alejos, J Jaime Miranda, Rohini Mathur, Pablo Perel, Liam Smeeth
OBJECTIVES: The EZSCAN is a non-invasive device that, by evaluating sweat gland function, may detect subjects with type 2 diabetes mellitus (T2DM). The aim of the study was to conduct a systematic review and meta-analysis including studies assessing the performance of the EZSCAN for detecting cases of undiagnosed T2DM. METHODOLOGY/PRINCIPAL FINDINGS: We searched for observational studies including diagnostic accuracy and performance results assessing EZSCAN for detecting cases of undiagnosed T2DM...
2017: PloS One
https://www.readbyqxmd.com/read/29082896/optimal-cut-off-points-of-fasting-and-post-glucose-stimulus-surrogates-of-insulin-resistance-as-predictors-of-metabolic-syndrome-in-adolescents-according-to-several-definitions
#15
Mónica Ivette Piña-Agüero, Aranza Zaldivar-Delgado, Alejandra Salas-Fernández, Azucena Martínez-Basila, Mariela Bernabe-García, Jorge Maldonado-Hernández
OBJECTIVE: The aim of this study was to determine optimal cut-off points of fasting and post-glucose stimulus surrogates of insulin resistance to predict metabolic syndrome in adolescents according to several definitions. METHODS: 155 adolescents living in Mexico City were enrolled during 2011 and 2012. Waist circumference and blood pressure were recorded. Subjects received an oral glucose load of 1.75g per kg up to a maximum dose of 75g. Blood samples were drawn at baseline and 120 minutes...
October 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29081355/the-ambivalent-place-of-ethics-in-european-regulatory-documents
#16
EDITORIAL
R D L C Bernabe, G J M W van Thiel, C C Gispen, N S Breekveldt, J J M van Delden
No abstract text is available yet for this article.
October 27, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29040556/cohort-profile-the-peru-migrant-study-a-prospective-cohort-study-of-rural-dwellers-urban-dwellers-and-rural-to-urban-migrants-in-peru
#17
Rodrigo M Carrillo-Larco, Andrea Ruiz-Alejos, Antonio Bernabé-Ortiz, Robert H Gilman, Liam Smeeth, J Jaime Miranda
No abstract text is available yet for this article.
July 25, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29028209/digital-implementation-of-the-two-compartmental-pinsky-rinzel-pyramidal-neuron-model
#18
Elahe Rahimian, Soheil Zabihi, Mahmood Amiri, Bernabe Linares-Barranco
It is believed that brain-like computing system can be achieved by the fusion of electronics and neuroscience. In this way, the optimized digital hardware implementation of neurons, primary units of nervous system, play a vital role in neuromorphic applications. Moreover, one of the main features of pyramidal neurons in cortical areas is bursting activities that has a critical role in synaptic plasticity. The Pinsky-Rinzel model is a nonlinear two-compartmental model for CA3 pyramidal cell that is widely used in neuroscience...
October 12, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29023513/fruits-and-vegetables-consumption-and-depressive-symptoms-a-population-based-study-in-peru
#19
Isabella Wolniczak, José A Cáceres-DelAguila, Jorge L Maguiña, Antonio Bernabe-Ortiz
OBJECTIVES: Among different factors, diet patterns seem to be related to depression. The aim of this study was to evaluate the association between the consumption of fruits and/or vegetables and depressive symptoms. METHODOLOGY/PRINCIPAL FINDINGS: A secondary data analysis was conducted using information from a population-based survey from 25 regions from Peru. The outcome was the presence of depressive symptoms according to the Patient Health Questionnaire (cutoff ≥15 to define major depressive syndrome); whereas the exposure was the self-reported consumption of fruits and/or vegetables (in tertiles and using WHO recommendation ≥5 servings/day)...
2017: PloS One
https://www.readbyqxmd.com/read/29017604/il-17-differentiated-macrophages-secrete-pro-inflammatory-cytokines-in-response-to-oxidized-low-density-lipoprotein
#20
María de la Paz Sánchez-Martínez, Francisco Blanco-Favela, Mónica Daniela Mora-Ruiz, Adriana Karina Chávez-Rueda, Mariela Bernabe-García, Luis Chávez-Sánchez
BACKGROUND: Cytokines and macrophages play a central role in the development of atherosclerosis. Interleukin (IL)-17 is a pro-inflammatory cytokine with differential effects on innate immune cells. We investigated the effects of IL-17 on macrophage differentiation and foam cell formation and activation in response to oxidized low-density lipoprotein (oxLDL). METHODS: Human monocytes were treated with IL-17 to induce macrophage differentiation. As controls, human monocytes were differentiated into M1 macrophages (M1) or M2 macrophages (M2)...
October 10, 2017: Lipids in Health and Disease
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