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Ángel Bernabé-García, Sergio Liarte, Jose M Moraleda, Gregorio Castellanos, Francisco J Nicolás
During wound healing, the migration of keratinocytes onto newly restored extracellular matrix aims to reestablish continuity of the epidermis. The application of amniotic membrane (AM) to chronic, deep traumatic, non-healing wounds has proven successful at stimulating re-epithelialization. When applied on epithelial cell cultures, AM activates extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases 1/2 (JNK1/2), with the overexpression and phosphorylation of c-Jun along the wound edge...
November 10, 2017: Scientific Reports
Piyada Gaewkhiew, Wael Sabbah, Eduardo Bernabé
INTRODUCTION/OBJECTIVE: A systematic review was conducted to explore whether tooth loss affects dietary intake and nutritional status among adults. DATA: Longitudinal studies of population-based or clinical samples of adults exploring the effect of tooth loss on food/dietary/nutrient intake and/or nutritional status were included for consideration. The risk of bias was assessed using the Newcastle-Ottawa Scale for cohort studies. SOURCES: A search strategy was designed to find published studies on MEDLINE, EMBASE and LILACS up to March 2017...
October 31, 2017: Journal of Dentistry
Antonio Bernabe-Ortiz, Andrea Ruiz-Alejos, J Jaime Miranda, Rohini Mathur, Pablo Perel, Liam Smeeth
OBJECTIVES: The EZSCAN is a non-invasive device that, by evaluating sweat gland function, may detect subjects with type 2 diabetes mellitus (T2DM). The aim of the study was to conduct a systematic review and meta-analysis including studies assessing the performance of the EZSCAN for detecting cases of undiagnosed T2DM. METHODOLOGY/PRINCIPAL FINDINGS: We searched for observational studies including diagnostic accuracy and performance results assessing EZSCAN for detecting cases of undiagnosed T2DM...
2017: PloS One
Mónica Ivette Piña-Agüero, Aranza Zaldivar-Delgado, Alejandra Salas-Fernández, Azucena Martínez-Basila, Mariela Bernabe-García, Jorge Maldonado-Hernández
OBJECTIVE: The aim of this study was to determine optimal cut-off points of fasting and post-glucose stimulus surrogates of insulin resistance to predict metabolic syndrome in adolescents according to several definitions. METHODS: 155 adolescents living in Mexico City were enrolled during 2011 and 2012. Waist circumference and blood pressure were recorded. Subjects received an oral glucose load of 1.75g per kg up to a maximum dose of 75g. Blood samples were drawn at baseline and 120 minutes...
October 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
R D L C Bernabe, G J M W van Thiel, C C Gispen, N S Breekveldt, J J M van Delden
No abstract text is available yet for this article.
October 27, 2017: Drug Discovery Today
Rodrigo M Carrillo-Larco, Andrea Ruiz-Alejos, Antonio Bernabé-Ortiz, Robert H Gilman, Liam Smeeth, J Jaime Miranda
No abstract text is available yet for this article.
July 25, 2017: International Journal of Epidemiology
Elahe Rahimian, Soheil Zabihi, Mahmood Amiri, Bernabe Linares-Barranco
It is believed that brain-like computing system can be achieved by the fusion of electronics and neuroscience. In this way, the optimized digital hardware implementation of neurons, primary units of nervous system, play a vital role in neuromorphic applications. Moreover, one of the main features of pyramidal neurons in cortical areas is bursting activities that has a critical role in synaptic plasticity. The Pinsky-Rinzel model is a nonlinear two-compartmental model for CA3 pyramidal cell that is widely used in neuroscience...
October 12, 2017: IEEE Transactions on Biomedical Circuits and Systems
Isabella Wolniczak, José A Cáceres-DelAguila, Jorge L Maguiña, Antonio Bernabe-Ortiz
OBJECTIVES: Among different factors, diet patterns seem to be related to depression. The aim of this study was to evaluate the association between the consumption of fruits and/or vegetables and depressive symptoms. METHODOLOGY/PRINCIPAL FINDINGS: A secondary data analysis was conducted using information from a population-based survey from 25 regions from Peru. The outcome was the presence of depressive symptoms according to the Patient Health Questionnaire (cutoff ≥15 to define major depressive syndrome); whereas the exposure was the self-reported consumption of fruits and/or vegetables (in tertiles and using WHO recommendation ≥5 servings/day)...
2017: PloS One
María de la Paz Sánchez-Martínez, Francisco Blanco-Favela, Mónica Daniela Mora-Ruiz, Adriana Karina Chávez-Rueda, Mariela Bernabe-García, Luis Chávez-Sánchez
BACKGROUND: Cytokines and macrophages play a central role in the development of atherosclerosis. Interleukin (IL)-17 is a pro-inflammatory cytokine with differential effects on innate immune cells. We investigated the effects of IL-17 on macrophage differentiation and foam cell formation and activation in response to oxidized low-density lipoprotein (oxLDL). METHODS: Human monocytes were treated with IL-17 to induce macrophage differentiation. As controls, human monocytes were differentiated into M1 macrophages (M1) or M2 macrophages (M2)...
October 10, 2017: Lipids in Health and Disease
María Antiñolo, Iván Bravo, Elena Jiménez, Bernabé Ballesteros, José Albaladejo
We report here the rate coefficients for the OH reactions (kOH) with E-CF3CH═CHF and Z-CF3CH═CHF, potential substitutes of HFC-134a, as a function of temperature (263-358 K) and pressure (45-300 Torr) by pulsed laser photolysis coupled to laser-induced fluorescence techniques. For the E-isomer, the existing discrepancy among previous results on the T dependence of kOH needs to be elucidated. For the Z-isomer, this work constitutes the first absolute determination of kOH. No pressure dependence of kOH was observed, while kOH exhibits a non-Arrhenius behavior: kOH(E) = [Formula: see text] and kOH(Z) = [Formula: see text] cm(3) molecule(-1) s(-1), where uncertainties are 2σ...
October 20, 2017: Journal of Physical Chemistry. A
Santiago Rodriguez-Perez, Antonio Serrano, Alba A Pantión, Bernabé Alonso-Fariñas
The search for new materials that replace fossil fuel-based plastics has been focused on biopolymers with similar physicochemical properties to fossil fuel-based plastics, such as Polyhydroxyalkanoates (PHA). The present paper reviews the challenges of scaling-up PHA production from waste streams during the period from 2014 to 2016, focusing on the feasibility of the alternatives and the most promising alternatives to its scaling-up. The reviewed research studies mainly focus on reducing costs or obtaining more valuable polymers...
January 1, 2018: Journal of Environmental Management
Amador García-Ruiz-de-Gordejuela, Zaida Agüera, Roser Granero, Trevor Steward, Asunción Llerda-Barberá, Elena López-Segura, Nuria Vilarrasa, Isabel Sanchez, Susana Jiménez-Murcia, Nuria Virgili, Rafael López-Urdiales, Mónica Montserrat-Gil de Bernabe, Pilar Garrido, Rosa Monseny, Carmen Monasterio, Neus Salord, Jordi Pujol-Gebelli, Jose M Menchón, Fernando Fernández-Aranda
This study aimed to explore the empirical trajectories of body mass index (BMI) 1 year following bariatric surgery (BS) and to identify the risk factors for each trajectory. The study included 115 patients with severe obesity who underwent BS. Assessment included metabolic variables, psychopathological and personality measures. Growth mixture modelling identified four separated trajectories for the percentage of total weight loss course shape (namely, T1 'good-fast', T2 'good', T3 'low' and T4 'low-slow')...
November 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
Mara Cavallin, Maria A Rujano, Nathalie Bednarek, Daniel Medina-Cano, Antoinette Bernabe Gelot, Severine Drunat, Camille Maillard, Meriem Garfa-Traore, Christine Bole, Patrick Nitschké, Claire Beneteau, Thomas Besnard, Benjamin Cogné, Marion Eveillard, Alice Kuster, Karine Poirier, Alain Verloes, Jelena Martinovic, Laurent Bidat, Marlene Rio, Stanislas Lyonnet, M Louise Reilly, Nathalie Boddaert, Melanie Jenneson-Liver, Jacques Motte, Martine Doco-Fenzy, Jamel Chelly, Tania Attie-Bitach, Matias Simons, Vincent Cantagrel, Sandrine Passemard, Alexandre Baffet, Sophie Thomas, Nadia Bahi-Buisson
Microlissencephaly is a rare brain malformation characterized by congenital microcephaly and lissencephaly. Microlissencephaly is suspected to result from abnormalities in the proliferation or survival of neural progenitors. Despite the recent identification of six genes involved in microlissencephaly, the pathophysiological basis of this condition remains poorly understood. We performed trio-based whole exome sequencing in seven subjects from five non-consanguineous families who presented with either microcephaly or microlissencephaly...
October 1, 2017: Brain: a Journal of Neurology
Juan Ruiz-García, Luis Borrego-Bernabé, Irene Canal-Fontcuberta, Eduardo Alegría-Barrero
No abstract text is available yet for this article.
October 2017: Archivos de Cardiología de México
John Flanagan, Thomas Bissot, Marie-Anne Hours, Bernabe Moreno, Alexandre Feugier, Alexander J German
INTRODUCTION: Obesity is a global concern in dogs with an increasing prevalence, and effective weight loss solutions are required that work in different geographical regions. The main objective was to conduct an international, multi-centre, weight loss trial to determine the efficacy of a dietary weight loss intervention in obese pet dogs. METHODS: A 3-month prospective observational cohort study of weight loss in 926 overweight dogs was conducted at 340 veterinary practices in 27 countries...
2017: PloS One
A Ramdaw, M T Hosey, E Bernabé
Objectives To assess the demographic, socioeconomic, behavioural and clinical factors associated with use of dental general anaesthesia (DGA) among British children.Methods This study used data from 3053 children who participated in the 2013 Children's Dental Health Survey in England, Wales and Northern Ireland. Data were collected through parental questionnaires and clinical examinations. The crude and adjusted association of demographic (sex, age, ethnicity and country of residence), socioeconomic (socioeconomic classification and area deprivation), behavioural (age toothbrushing started, age when first went to the dentist, usual reason for dental visit and dental anxiety) and clinical factors (numbers of decayed and filled teeth) with DGA was assessed in logistic regression models...
September 8, 2017: British Dental Journal
Raúl López-Antón, Juan Ramón Barrada, Javier Santabárbara, Mar Posadas-de Miguel, Luís Agüera, Carmen Burillo, Manuel Franco, Jorge López-Álvarez, Pilar Mesa, Roberto Petidier, Miguel Ángel Quintanilla, Bernabé Robles-Del Olmo, Tirso Ventura, Maya Semrau, Norman Sartorius, Antonio Lobo
OBJECTIVE: The IDEAL Schedule was developed for staging "care needs" in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for "care needs". METHODS: A multicenter study was done in 8 dementia care facilities across Spain. Patients referred with a reliable ICD-10 diagnosis of dementia (n = 151) were assessed with the IDEAL Schedule by pairs of raters. Inter-rater reliability (intra-class correlation [ICC] coefficients), internal consistency (Cronbach's alpha), and factor analysis were calculated...
August 31, 2017: International Journal of Geriatric Psychiatry
Olga Cortés, Antonia Alcaina, Antonia Bernabé
BACKGROUND: In many cases, the indirect pulp treatment (IPT) is an acceptable treatment for deciduous teeth with reversible pulp inflammation. Various medicaments have been used for IPT, ranging from calcium hydroxide and glass ionomers to dentin adhesives. OBJECTIVE: This in vitro trial aimed to measure cytotoxicity in a cell culture, comparing the following four adhesives: Xeno® V (XE), Excite® F DSC (EX), Adhese® OneF (AD) and Prime & Bond NT (PB). MATERIALS AND METHODS: The adhesives were prepared according to the manufacturer's instructions...
June 2017: Acta Stomatologica Croatica
T Siddharthan, M Grigsby, C H Miele, A Bernabe-Ortiz, J J Miranda, R H Gilman, R A Wise, J C Porter, J R Hurst, W Checkley
INTRODUCTION: Few studies have described the prevalence of and lung function decline among those with a restrictive spirometric pattern (RSP) in low- and middle-income countries. METHODS: We analyzed prospective data from 3055 adults recruited across four diverse settings in Peru over a 3-year period. Multivariable logistic regression was used to study the association between the presence of restriction and associated risk factors. Multivariable linear mixed models were used to determine lung function decline...
September 1, 2017: International Journal of Tuberculosis and Lung Disease
L A Lansdon, H V Bernabe, N Nidey, J Standley, M J Schnieders, J C Murray
Here we describe the genotype-phenotype correlations of diseases caused by variants in Fibroblast Growth Factor Receptor 1 ( FGFR1) and report a novel, de novo variant in FGFR1 in an individual with multiple congenital anomalies. The proband presented with bilateral cleft lip and palate, malformed auricles, and bilateral ectrodactyly of his hands and feet at birth. He was later diagnosed with diabetes insipidus, spastic quadriplegia, developmental delay, agenesis of the corpus callosum, and enlargement of the third cerebral ventricle...
October 2017: Journal of Dental Research
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