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https://www.readbyqxmd.com/read/28736513/low-cigarette-smoking-prevalence-in-peri-urban-peru-results-from-a-population-based-study-of-tobacco-use-by-self-report-and-urine-cotinine
#1
Brooks W Morgan, Kathryn M Leifheit, Karina M Romero, Robert H Gilman, Antonio Bernabe-Ortiz, J Jaime Miranda, Harold I Feldman, John J Lima, William Checkley
BACKGROUND: A recent study found lower self-reported prevalence of tobacco smoking in a peri-urban area of Lima, Peru than previously reported in urban samples. These regions encompass substantial proportions of Peru's population - ones at greater risk of disease due to reduced healthcare access - but have been less often studied. We validate low smoking prevalence with urine cotinine and characterize chronic disease and lung function outcomes between non-, occasional, and daily smokers...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28712003/association-between-chronic-conditions-and-health-related-quality-of-life-differences-by-level-of-urbanization-in-peru
#2
Alvaro Taype-Rondan, Elizabeth Sarah Abbs, Maria Lazo-Porras, William Checkley, Robert H Gilman, Liam Smeeth, J Jaime Miranda, Antonio Bernabe-Ortiz
PURPOSE: To evaluate the role of urbanization as an effect modifier for the association between specific chronic conditions and number of conditions with health-related quality of life (QOL). METHODS: We analyzed cross-sectional data from the CRONICAS Cohort Study conducted in Lima (highly urbanized), Tumbes (semi-urban), as well as rural and urban sites in Puno. Exposures of interest were chronic bronchitis, depressive mood, hypertension, type 2 diabetes, and a composite variable aggregating the number of chronic conditions (the four exposures plus heart disease and stroke)...
July 15, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28705671/antibiotic-resistance-in-west-africa-a-systematic-review-and-meta-analysis
#3
REVIEW
Kerlly J Bernabé, Céline Langendorf, Nathan Ford, Jean-Baptiste Ronat, Richard A Murphy
BACKGROUND: Growing data suggest that antibiotic-resistant bacterial infections are common in low and middle-income countries. This review summarizes the microbiology of key bacterial syndromes encountered in West Africa and estimates the prevalence of antimicrobial resistance (AMR) that could compromise first-line empirical treatment. METHODS: We systematically searched for studies reporting on the epidemiology of infection and AMR in West Africa. Within each syndrome, the pooled proportion and 95% confidence intervals were calculated for each pathogen-antibiotic pair, using random effects models...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28701911/an-event-driven-classifier-for-spiking-neural-networks-fed-with-synthetic-or-dynamic-vision-sensor-data
#4
Evangelos Stromatias, Miguel Soto, Teresa Serrano-Gotarredona, Bernabé Linares-Barranco
This paper introduces a novel methodology for training an event-driven classifier within a Spiking Neural Network (SNN) System capable of yielding good classification results when using both synthetic input data and real data captured from Dynamic Vision Sensor (DVS) chips. The proposed supervised method uses the spiking activity provided by an arbitrary topology of prior SNN layers to build histograms and train the classifier in the frame domain using the stochastic gradient descent algorithm. In addition, this approach can cope with leaky integrate-and-fire neuron models within the SNN, a desirable feature for real-world SNN applications, where neural activation must fade away after some time in the absence of inputs...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28693514/disparities-in-dietary-intake-and-physical-activity-patterns-across-the-urbanization-divide-in-the-peruvian-andes
#5
Morgan L McCloskey, Carla E Tarazona-Meza, Jessica C Jones-Smith, Catherine H Miele, Robert H Gilman, Antonio Bernabe-Ortiz, J Jaime Miranda, William Checkley
BACKGROUND: Diet and activity are thought to worsen with urbanization, thereby increasing risk of obesity and chronic diseases. A better understanding of dietary and activity patterns across the urbanization divide may help identify pathways, and therefore intervention targets, leading to the epidemic of overweight seen in low- and middle-income populations. Therefore, we sought to characterize diet and activity in a population-based study of urban and rural residents in Puno, Peru. METHODS: We compared diet and activity in 1005 (503 urban, 502 rural) participants via a lifestyle questionnaire...
July 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28683081/the-evaluation-and-planning-method-of-spanish-sport-and-physical-activity-instructors-a-comparative-study-across-gender-age-level-of-studies-and-work-experience
#6
Beatriz Bernabé, María Dolores González-Rivera, Antonio Campos-Izquierdo
The purpose of this study is to investigate the planning and the evaluation of Spanish sport and physical activity instructors as well as to analyze and compare the two variables in terms of their gender, age, level of studies and work experience. This research falls inside the quantitative type methodology of descriptive cut through standardized interview using the standardized questionnaire: "Human resources of sport and physical activity". It analyses the situation and performance of people working in functions of sport and physical activity...
2017: PloS One
https://www.readbyqxmd.com/read/28678190/taste-salt-consumption-and-local-explanations-around-hypertension-in-a-rural-population-in-northern-peru
#7
M Amalia Pesantes, Francisco Diez-Canseco, Antonio Bernabé-Ortiz, Vilarmina Ponce-Lucero, J Jaime Miranda
Interventions to promote behaviors to reduce sodium intake require messages tailored to local understandings of the relationship between what we eat and our health. We studied local explanations about hypertension, the relationship between local diet, salt intake, and health status, and participants' opinions about changing food habits. This study provided inputs for a social marketing campaign in Peru promoting the use of a salt substitute containing less sodium than regular salt. Qualitative methods (focus groups and in-depth interviews) were utilized with local populations, people with hypertension, and health personnel in six rural villages...
July 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28673713/alterations-in-opioid-inhibition-cause-widespread-nociception-but-do-not-affect-anxiety-like-behavior-in-oral-cancer-mice
#8
Yi Ye, Daniel G Bernabé, Elizabeth Salvo, Chi T Viet, Kentaro Ono, John C Dolan, Malvin Janal, Brad E Aouizerat, Christine Miaskowski, Brian L Schmidt
Widespread pain and anxiety are commonly reported in cancer patients. We hypothesize that cancer is accompanied by attenuation of endogenous opioid-mediated inhibition, which subsequently causes widespread pain and anxiety. To test this hypothesis we used a mouse model of oral squamous cell carcinoma (SCC) in the tongue. We found that mice with tongue SCC exhibited widespread nociceptive behaviors in addition to behaviors associated with local nociception that we reported previously. Tongue SCC mice exhibited a pattern of reduced opioid receptor expression in the spinal cord; intrathecal administration of respective mu (MOR), delta (DOR), and kappa (KOR) opioid receptor agonists reduced widespread nociception in mice, except for the fail flick assay following administration of the MOR agonist...
June 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28671476/molecular-group-13-metallaborates-derived-from-m-o-m-cleavage-promoted-by-bh3
#9
Erandi Bernabé-Pablo, Vojtech Jancik, Diego Martínez-Otero, Joaquín Barroso-Flores, Mónica Moya-Cabrera
The reaction of metalloxanes [{(Me)LM(OH)}2(μ-O)] [M = Al (1), Ga (2); (Me)L = CH{CMe(NAr)}2(-), Ar = 2,4,6-Me3C6H2, Me = methyl] with an excess of BH3·D (D = tetrahydrofuran (THF), SMe2) affords annular metallaborate systems achieved through M-O-M cleavage. Compound 1 led exclusively to the formation of eight-membered ring systems [{(Me)LAl(μ-O){B(O(n)Bu)}(μ-O)}2] (3) and [{(Me)LAl(μ-O)(BH)(μ-O)}2] (6), while for 2 the unprecedented six-membered ring systems [{((Me)LGa)2(μ-O)}(μ-O)2{B(O(n)Bu)}] (4) and [((Me)LGa)(μ-O)2{(BO(n)Bu)2(μ-O)}] (5) were observed...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28662386/phenols-recovery-after-steam-explosion-of-olive-mill-solid-waste-and-its-influence-on-a-subsequent-biomethanization-process
#10
Antonio Serrano, Fernando G Fermoso, Bernabé Alonso-Fariñas, Guillermo Rodríguez-Gutierrez, Juan Fernandez-Bolaños, Rafael Borja
A promising source of high added value compounds is the Olive Mill Solid Waste (OMSW). The aim of this research was to evaluate the viability of a biorefinery approach to valorize OMSW through the combination of steam explosion, phenols extraction, and anaerobic digestion. Steam explosion treatment increased the total phenol content in the steam exploited OMSW, which was twice than that the total phenol content in raw OMSW, although some undesirable compounds were also formed. Phenol extraction allowed the recovery of 2098mg hydroxytyrosol per kg of OMSW...
June 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28657330/multiple-t-dna-delivery-to-plants-using-novel-mini-binary-vectors-with-compatible-replication-origins
#11
Fabio Pasin, Leonor C Bedoya, Joan Miquel Bernabé-Orts, Araíz Gallo, Carmen Simón-Mateo, Diego Orzaez, Juan Antonio García
Improved plants are necessary to meet human needs. Agrobacterium-mediated transformation is the most common method used to rewire plant capabilities. For plant gene delivery, DNA constructs are assembled into binary T-DNA vectors that rely on broad host range origins for bacterial replication. Here we present pLX vectors, a set of mini binary T-DNA plasmids suitable for Type IIS restriction endonuclease- and overlap-based assembly methods. pLX vectors include replicons from compatible broad host range plasmids...
June 28, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28655504/early-life-factors-and-dental-caries-in-5-year-old-children-in-china
#12
Xiangyu Sun, Eduardo Bernabé, Xuenan Liu, Jennifer E Gallagher, Shuguo Zheng
OBJECTIVES: This study aimed to explore the association between early life factors and dental caries among 5-year-old Chinese children. METHODS: Data from 9,722 preschool children who participated in the third National Oral Health Survey of China were analysed. Information on early life (birth weight, breastfeeding and age when toothbrushing started), child (sex, ethnicity, birth order and dental behaviours) and family factors (parental education, household income, place of residence, number of children in the family, respondent's age and relation to the child) were obtained from parental questionnaires...
June 24, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28640966/linking-the-degree-of-virilization-in-females-with-congenital-adrenal-hyperplasia-to-genotype
#13
Semyon Gurgov, Kerlly J Bernabé, John Stites, Christopher M Cunniff, Karen Lin-Su, Diane Felsen, Maria I New, Dix P Poppas
Mutations of CYP21A2 variably decrease 21-hydroxylase activity and result in a spectrum of disease expressions in patients with congenital adrenal hyperplasia (CAH). We examined the association between CYP21A2 mutations and virilization (Prader score) in females with CAH. The study population included 187 CAH females with fully characterized CYP21A2 mutations. One hundred fifty-eight patients were sorted into groups by expected enzyme activity (percent of normal activity) of the less severely affected allele: (A) null, 0%; (B) I2G, 1%; (C) I172N, 2%; and (D) V281L, >2%...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28633647/meeting-the-oral-health-needs-of-12-year-olds-in-china-human-resources-for-oral-health
#14
Xiangyu Sun, Eduardo Bernabé, Xuenan Liu, Shuguo Zheng, Jennifer E Gallagher
BACKGROUND: An appropriate level of human resources for oral health [HROH] is required to meet the oral health needs of population, and enable maximum improvement in health outcomes. The aim of this study was to estimate the required HROH to meet the oral health needs of the World Health Organization [WHO] reference group of 12-year-olds in China and consider the implications for education, practice, policy and HROH nationally. METHODS: We estimated the need of HROH to meet the needs of 12-year-olds based on secondary analysis of the epidemiological and questionnaire data from the 3rd Chinese National Oral Health Survey, including caries experience and periodontal factors (calculus), dentally-related behaviour (frequency of toothbrushing and sugar intake), and social factors (parental education)...
June 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28624967/routes-and-machinery-of-primary-cilium-biogenesis
#15
REVIEW
Miguel Bernabé-Rubio, Miguel A Alonso
Primary cilia are solitary, microtubule-based protrusions of the cell surface that play fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary cilia dysfunction results in a long list of developmental and degenerative disorders that combine to give rise to a large spectrum of human diseases affecting almost any major body organ. Depending on the cell type, primary ciliogenesis is initiated intracellularly, as in fibroblasts, or at the cell surface, as in renal polarized epithelial cells...
June 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28621502/amniotic-membrane-stimulates-cell-migration-by-modulating-transforming-growth-factor-%C3%AE-signaling
#16
Catalina Ruiz-Cañada, Ángel Bernabé-García, Sergio Liarte, Carmen Luisa Insausti, Diego Angosto, José María Moraleda, Gregorio Castellanos, Francisco José Nicolás
Keratinocyte migration is a mandatory aspect of wound-healing. We have previously shown that Amniotic Membrane (AM) applied to chronic wounds assists healing through a process resulting in overexpression of c-Jun at the wound's leading edge. Also, we have demonstrated that amniotic membrane modifies the genetic program induced by TGF-ß in chronic wounds. In this paper, we used a scratch assay of Mv1Lu and HaCaT cells to examine the influence of AM application on the underlying signaling during scratch closure...
June 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28619761/exhaled-breath-condensate-biomarkers-for-the-early-diagnosis-of-lung-cancer-using-proteomics
#17
Laura M López-Sánchez, Bernabé Jurado-Gámez, Nuria Feu-Collado, Araceli Valverde, Amanda Cañas, Jose L Fernández-Rueda, Enrique Aranda, Antonio Rodríguez-Ariza
We explored whether the proteomic analysis of exhaled breath condensate (EBC) may provide biomarkers for non-invasive screening for the early detection of lung cancer (LC). EBC was collected from 192 individuals (49 control (C), 49 risk factor-smoking (S), 46 chronic obstructive pulmonary disease (COPD) and 48 LC (LC)). Using LC-MS/MS, 348 different proteins with a different pattern among the four groups were identified in EBC samples. Significantly more proteins were identified in the EBC from LC compared to other groups (C:12...
June 15, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28609695/what-do-we-need-to-make-circulating-tumour-dna-ctdna-a-routine-diagnostic-test-in-lung-cancer
#18
REVIEW
Reyes Bernabé, Nicholas Hickson, Andrew Wallace, Fiona Helen Blackhall
The gold standard test for detection of epidermal growth factor receptor (EGFR) mutation is to genotype somatic DNA extracted from a tissue biopsy or cytology specimen. Yet, in at least 20% of patients this is not possible for various reasons including insufficient availability of neoplastic tissue, lack of fitness of the available tissue for a biopsy or that a biopsy is not technically feasible. Consequently, there has been intense investigation of circulating tumour DNA (ctDNA), released into the plasma fraction of blood from cancer cells during apoptosis/necrosis, as a minimally invasive 'liquid biopsy' and surrogate for cancer tissue...
August 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28600187/vascular-endothelial-growth-factor-influences-migration-and-focal-adhesions-but-not-proliferation-or-viability-of-human-neural-stem-progenitor-cells-derived-from-olfactory-epithelium
#19
Gerardo Bernabé Ramírez-Rodríguez, Gerardo Rodrigo Perera-Murcia, Leonardo Ortiz-López, Nelly Maritza Vega-Rivera, Harish Babu, Maria García-Anaya, Jorge Julio González-Olvera
In humans, new neurons are continuously added in the olfactory epithelium even in the adulthood. The resident neural stem/progenitor cells (hNS/PCs-OE) in the olfactory epithelium are influenced by several growth factors and neurotrophins. Among these modulators the vascular endothelial growth factor (VEGF) has attracted attention due its implicated in cell proliferation, survival and migration of other type of neural/stem progenitor cells. Interestingly, VEGFr2 receptor expression in olfactory epithelium has been described in amphibians but not in humans...
June 7, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28578370/uncommon-oral-manifestation-of-lichen-sclerosus-critical-analysis-of-cases-reported-from-1957-to-2016
#20
S Tomo, I-S Santos, S-A de Queiroz, D-G Bernabé, L-E Simonato, G-I Miyahara
BACKGROUND: Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literature from 1957 to 2016, looking to provide valuable evidence about clinicopathologic features of this disease. MATERIAL AND METHODS: A MedLine search was performed aiming to find oral lichen sclerosus cases in literature and discuss its demographical and pathological characteristics as well as treatment methods performed for these cases...
July 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
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