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Alvaro Avezum, Gustavo B F Oliveira, Fernando Lanas, Patricio Lopez-Jaramillo, Rafael Diaz, J Jaime Miranda, Pamela Seron, Paul A Camacho-Lopez, Andres Orlandini, Antonio Bernabe-Ortiz, Antônio Cordeiro Mattos, Shofiqul Islam, Sumathy Rangarajan, Koon Teo, Salim Yusuf
BACKGROUND: Despite the availability of evidence-based therapies, there is no information on the use of medications for the secondary prevention of cardiovascular disease in urban and rural community settings in South America. OBJECTIVES: This study sought to assess the use, and its predictors, of effective secondary prevention therapies in individuals with a history of coronary heart disease (CHD) or stroke. METHODS: In the PURE (Prospective Urban Rural Epidemiological) study, we enrolled 24,713 individuals from South America ages 35 to 70 years from 97 rural and urban communities in Argentina, Brazil, Chile, and Colombia...
October 20, 2016: Global Heart
Ketelin Juliane Dal Prá, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Marcelo Macedo Crivelini, Kellen Cristine Tjioe
Pyogenic granuloma is a common cause of growth of soft tissue in the oral cavity, especially in the gingiva. It is mainly associated with local and chronic irritants besides hormonal changes during pregnancy. Here, the authors present an unusual patient of an extra-gingival pyogenic granuloma with large dimensions and displacing teeth arising in a male patient. This is an interesting patient to be reported due to its exacerbated and atypical clinical features.
October 14, 2016: Journal of Craniofacial Surgery
Aneliza de Fatima Moraes da Silva, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Renata Callestini, Kellen Cristine Tjioe
Oral biopsy of vesiculobullous diseases such as pemphigus vulgaris often raises questions due to some particularities involving this procedure. The adequate selection of the area to be biopsied defines if the final diagnosis will be reached, being the Achiles heel of the proper management of the patient. Here, the authors report a case of a woman who sought for treatment of generalized oral blisters and ulcers that caused severe pain. She had undergone a previous biopsy by other professionals that was inconclusive...
October 14, 2016: Journal of Craniofacial Surgery
Bernabé Ballesteros, Elena Jiménez, Alberto Moreno, Amparo Soto, María Antiñolo, José Albaladejo
Rate coefficients for the gas-phase reactions of CxF2x+1CHCH2 (x = 1, 2, 3, 4 and 6) with Cl atoms were determined at (298 ± 2) K and (710 ± 5) Torr of air using a relative rate technique. Two experimental setups with simulation chambers were employed with Fourier Transform Infrared (FTIR) spectroscopy and Gas Chromatography coupled to Mass Spectrometry (GC-MS) as detection techniques. The Cl-rate coefficients obtained were (in 10(-10) cm(3) molecule(-1) s(-1)): (0.85 ± 0.11) for CF3CHCH2, (1...
October 10, 2016: Chemosphere
Bernabé Santelices, Alejandra V González, Jessica Beltrán, Verónica Flores
Chimerism is produced by the somatic fusion of two or more genetically distinct conspecific individuals. In animals, the main cost of fusion is competition between genetically different cell lineages and the probability of original cell-line replacement by more competitive invasive lines, which limits its natural frequency (3-5%). In red and brown seaweeds, chimerism is widespread (27-53%), seemingly without the negative outcomes described for animals. The rigidity of cell walls in macroalgae prevents cell motility and invasions...
October 7, 2016: Journal of Phycology
Antonio Bernabé-Ortiz, Rodrigo M Carrillo-Larco, Robert H Gilman, Catherine H Miele, William Checkley, Jonathan C Wells, Liam Smeeth, J Jaime Miranda
BACKGROUND: The study aims were to estimate the incidence and risk factors for T2D in four settings with different degree of urbanization and altitude in Peru. METHODS: Prospective cohort study conducted in urban, semi-urban, and rural areas in Peru. An age- and sex-stratified random sample of participants was taken from the most updated census. T2D was defined as fasting blood glucose ⩾7.0mmol/L or taking anti-diabetes medication. Exposures were divided into two groups: geographical variables (urbanization and altitude), and modifiable risk factors...
September 21, 2016: Diabetes Research and Clinical Practice
Xiangyu Sun, Eduardo Bernabé, Xuenan Liu, Jennifer E Gallagher, Shuguo Zheng
AIM: To explore the association between contextual factors and periodontal disease. METHODS: We pooled individual-level data from 20,204 35-44-year-olds and 9,666 65-74-years-olds, who participated in the 3(rd) National Oral Health Survey in China (2005), with province-level data from different sources. The association of provincial macroeconomic factors (Gross Domestic Product [GDP] per capita and Gini coefficient), health resources (public health expenditure, dentist to population ratio and dental therapist to population ratio), demographic composition (proportion of rural population and minority ethnic groups) and tobacco industry (tobacco crops, cigarette production and proportion of smokers) with the numbers of teeth with periodontal pocket depth (PPD)>4mm and loss of attachment (LOA)>4mm were assessed in multilevel models, controlling for individual-level demographic, socioeconomic and behavioural factors...
October 5, 2016: Journal of Clinical Periodontology
Antonio Bernabe-Ortiz, Liam Smeeth, Robert H Gilman, Jose R Sanchez-Abanto, William Checkley, J Jaime Miranda, Cronicas Cohort Study Group
Objective. To develop and validate a risk score for detecting cases of undiagnosed diabetes in a resource-constrained country. Methods. Two population-based studies in Peruvian population aged ≥35 years were used in the analysis: the ENINBSC survey (n = 2,472) and the CRONICAS Cohort Study (n = 2,945). Fasting plasma glucose ≥7.0 mmol/L was used to diagnose diabetes in both studies. Coefficients for risk score were derived from the ENINBSC data and then the performance was validated using both baseline and follow-up data of the CRONICAS Cohort Study...
2016: Journal of Diabetes Research
Leonardo Ortiz-López, Nelly Maritza Vega-Rivera, Harish Babu, Gerardo Bernabé Ramírez-Rodríguez
The generation of new neurons during adulthood involves local precursor cell migration and terminal differentiation in the dentate gyrus. These events are influenced by the hippocampal microenvironment. Brain-derived neurotrophic factor (BDNF) is relevant for hippocampal neuronal development and behavior. Interestingly, studies that have been performed in controlled in vitro systems that involve isolated precursor cells that were derived from the dentate gyrus (AHPCs) have shown that BDNF induces the activation of the TrkB receptor and, consequentially, might activate signaling pathways that favor survival and neuronal differentiation...
September 24, 2016: Neurotoxicity Research
Flavia A Díaz-Garcés, Iván Vargas-Matos, Antonio Bernabé-Ortiz, Francisco Diez-Canseco, Antonio J Trujillo, J Jaime Miranda
Community Kitchens (CKs) are one of the main food providers to low-income families in Peru and may encourage healthier diets. We aimed to determine the prevalence of fruit and vegetable consumption and associated sociodemographic and behavioral factors among CKs customers. A cross-sectional study enrolling customers of 48 CKs in two areas of Lima, Peru, was performed. The self-reported amount of fruits and vegetables consumed (< 5 vs. ≥ 5 servings/day) was the outcome. The exposures were grouped in sociodemographic variables (i...
December 2016: Preventive Medicine Reports
Jeffrey Michael Smith, Shivam Gupta, Emma Williams, Kate Brickson, Keth Ly Sotha, Navuth Tep, Anthony Calibo, Mary Christine Castro, Bernabe Marinduque, Mark Hathaway
OBJECTIVE: To determine whether a simple quality improvement initiative consisting of a technical update and regular audit and feedback sessions will result in increased use of antenatal corticosteroids among pregnant women at risk of imminent preterm birth delivering at health facilities in the Philippines and Cambodia. DESIGN: Non-randomized, observational study using a pre-/post-intervention design conducted between October 2013 and June 2014. SETTING: A total of 12 high volume facilities providing Emergency Obstetric and Newborn Care services in Cambodia (6) and Philippines (6)...
September 10, 2016: International Journal for Quality in Health Care
Paloma González-Gil de Bernabé, José María Montiel-Company, Vanessa Paredes-Gallardo, Jose Luis Gandía-Franco, Carlos Bellot-Arcís
OBJECTIVE: To examine medium- to long-term orthodontic treatment stability and its possible association with certain variables. MATERIALS AND METHODS: In a retrospective longitudinal study of 70 postretention patients, the Peer Assessment Rating (PAR) index was measured at the start (T1) and end (T2) of treatment and between 4 and 10 years afterwards (T3). The stability was considered absolute when the T2 and T3 values were identical and relative when the difference was within the ±5 range...
September 6, 2016: Angle Orthodontist
C Chéhensse, P Clément, C Joussain, J Bernabé, F Giuliano
The inability to ejaculate, i.e. anejaculation, affects the vast majority of men after spinal cord injury (SCI). Ejaculation can however be obtained in approximately half of SCI men by applying extraphysiological vibratory stimulation to the penis suggesting that a spinal neural organization commanding ejaculation exists than can be activated despite disruption of cerebral connections. In the rat, a spinal generator of ejaculation (SGE) has been identified which is notably characterized by the presence of substance P (SP) receptor (neurokinin-1 receptor) onto the constituting neurons...
November 12, 2016: Neuroscience
Gregorio Bernabé García, Josefa González-Carrillo, Javier Cuenca Muñoz, Daniel Rodríguez Sánchez, Daniel Saura Espín, Juan Ramón Gimeno Blanes
No abstract text is available yet for this article.
August 26, 2016: Revista Española de Cardiología
Antonio Bernabe-Ortiz, Francisco Diez-Canseco, Alberto Vasquez, Hannah Kuper, Matthew Walsham, Karl Blanchet
OBJECTIVE: This study aims to assess the needs of people with disabilities and their level of inclusion in social protection programmes. DESIGN: Population based-survey with a nested case-control study. SETTING: Morropon, a semiurban district located in Piura, northern Peru. PARTICIPANTS: For the population survey, a two-stage sampling method was undertaken using data from the most updated census available and information of each household member aged ≥5 years was collected...
2016: BMJ Open
Francisco Ferrero-Manzanal, Raquel Lax-Pérez, Roberto López-Bernabé, José Ramiro Betancourt-Bastidas, Alvaro Iñiguez de Onzoño-Pérez
INTRODUCTION: Shoulder surgery is often performed with the patient in the so called "beach-chair position" with elevation of the upper part of the body. The anesthetic procedure can be general anesthesia and/or regional block, usually interscalenic brachial plexus block. We present a case of brachial plexus palsy with a possible mechanism of traction based on the electromyographic and clinical findings, although a possible contribution of nerve block cannot be excluded. PRESENTATION OF THE CASE: We present a case of a 62 year-old female, that suffered from shoulder fracture-dislocation...
2016: International Journal of Surgery Case Reports
J Cerezo, M Bernabé, A Lisbona, F J Palací
INTRODUCTION: Socialization during the training of specialists is a key step in the subsequent adjustment and occupational well-being of health professionals in the hospital organisation. OBJECTIVE: To analyse the relationship of socialization and resilience with the engagement responses of specialists in training. METHOD: Convenience sampling was used, with 110 professionals from six teaching units of different hospitals participating in the study...
August 17, 2016: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
Marco Cossío Bolaños, Jorge Méndez Cornejo, Cristian Luarte Rocha, Rodrigo Vargas Vitoria, Bernabé Canqui Flores, Rossana Gomez Campos
INTRODUCTION: Regular physical activity (PA) during childhood and adolescence is important for the prevention of non-communicable diseases and their risk factors. OBJECTIVES: To validate a questionnaire for measuring patterns of PA, verify the reliability, comparing the levels of PA aligned with chronological and biological age, and to develop percentile curves to assess PA levels depending on biological maturation. SUBJECTS AND METHOD: Descriptive cross-sectional study was performed on a sample non-probabilistic quota of 3,176 Chilean adolescents (1685 males and 1491 females), with a mean age range from 10...
August 16, 2016: Revista Chilena de Pediatría
Hilda-Beatriz Gómez-Robledo, Francisco Cruz-Sosa, Antonio Bernabé-Antonio, Antonio Guerrero-Analco, José Luis Olivares-Romero, Alexandro Alonso-Sánchez, Emanuel Villafán, Enrique Ibarra-Laclette
BACKGROUND: Calophyllum brasiliense is highlighted as an important resource of calanolides, which are dipyranocoumarins that inhibit the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). Despite having great medicinal importance, enzymes involved in calanolide, biosynthesis and the pathway itself, are still largely unknown. Additionally, no genomic resources exist for this plant species. RESULTS: In this work, we first analyzed the transcriptome of C...
2016: BMC Plant Biology
S Zaeh, C H Miele, N Putcha, R H Gilman, J J Miranda, A Bernabe-Ortiz, R A Wise, W Checkley
SETTING: Depression is a prevalent comorbidity of chronic respiratory disease (CRD), and may indicate worse clinical outcomes. The relationship between depression and living with chronic hypoxia due to CRD or residence at altitude has received little attention in resource-poor settings. OBJECTIVE: To investigate the association between CRD conditions and depressive symptoms in four settings in Peru. DESIGN: We collected data on CRD and depressive symptoms in adults aged ⩾35 years...
September 2016: International Journal of Tuberculosis and Lung Disease
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