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https://www.readbyqxmd.com/read/27910775/hepatoprotective-effects-and-mechanisms-of-action-of-triterpenoids-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-%C3%AE-amanitin-induced-liver-injury-in-mice
#1
Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910757/free-radical-scavenging-activities-of-cultured-mycelia-of-paecilomyces-hepiali-ascomycetes-extracts-and-structural-characterization-of-bioactive-components-by-nuclear-magnetic-resonance-spectroscopy
#2
Lucia Ungvarska Mal'ucka, Jarmila Harvanova, Martin Pavlik, Martin Rajtar, Lukas Jarosciak
Current research is focused on testing the cultivation of Paecilomyces hepiali mycelia on various plant substrates and producing fungus or mycelial biomass with qualitatively interesting substances. P. hepiali mycelia was cultivated using solid-state fermentation of different substrates. Mycelial biomass was then analyzed, and antioxidant activity was evaluated using the DPPH radical scavenging method for different ethanolic extracts based on a millet substrate (extract 1) or a chickpea substrate (extract 2)...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910755/comparison-of-the-composition-and-antioxidant-activities-of-phenolics-from-the-fruiting-bodies-of-cultivated-asian-culinary-medicinal-mushrooms
#3
Shaoling Lin, Lai Tsz Ching, Xinxin Ke, Peter Chi Keung Cheung
The composition profile and the antioxidant properties of phenolics in water extracts obtained from the fresh fruiting bodies of 4 common cultivated Asian edible mushrooms-Agrocybe aegerita, Pleurotus ostreatus, P. eryngii, and Pholiota nameko were compared. The water extract from A. aegerita (AaE) had the highest total phenolic content (TPC) at 54.18 ± 0.27 gallic acid equivalents (μmol/L)/mg extract (P < 0.05), as measured by the Folin-Ciocalteu method, and consisted of the largest number (including gallic acid, protocatechuic acid, chlorogenic acid, ferulic acid, and sinapic acid) and total amounts of phenolic acids identified by Fourier transform-ion cyclotron resonance mass spectrometry...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910164/hplc-uv-and-lc-ms-analyses-of-acylquinic-acids-in-geigeria-alata-dc-oliv-hiern-and-their-contribution-to-antioxidant-and-antimicrobial-capacity
#4
Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Maya M Zaharieva, Hristo Najdenski, Silviya Ruseva, Valentin Lozanov, Vessela Balabanova, Sakina Yagi, Georgi Momekov, Vanio Mitev
INTRODUCTION: Geigeria alata is a traditional plant used in Sudanese folk medicine for treatment of diabetes, cough, epilepsy and intestinal complaints. OBJECTIVE: To analyze phenolic acids in Geigeria alata roots and leaves and to evaluate their antioxidant and antimicrobial activities. METHODOLOGY: Phenolic acids in the aqueous-methanol extracts were identified by LC-MS. Major compounds were isolated using low-pressure liquid chromatography...
December 1, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27909966/oxidative-balance-in-rats-during-adaptation-to-swimming-load
#5
A V Elikov
The main parameters of free radical oxidation and antioxidant defense in the blood plasma, erythrocytes, and homogenates of skeletal muscles, heart, liver, lungs, and kidneys were studied in adult outbred albino male rats with different degree of adaptation to moderate exposure to swimming. The rats were trained to swim regularly over 1 month. Changes in oxidative balance varied in organs and tissues and depended on the level of training. Malonic dialdehyde content in the erythrocytes after swimming increased by 13...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27909965/correction-of-negative-effect-of-antenatal-hypoxia-on-liver-tissue-homeostasis-in-newborn-albino-rats-with-opioid-peptides
#6
O G Pinaeva, E N Sazonova, O A Lebed'ko, S S Timoshin
We studied the possibility of correction of the negative effects of antenatal hypoxia on the liver tissue homeostasis in 7-day-old albino rats by administration of opioid peptides in a dose of 100 μg/kg on postnatal days 2-6. Administration of mixed μ/δ-opioid receptor agonist Dalargin neutralized deviations of gravimetric indicators, parameters of proliferative activity, and activity of the nucleolar apparatus of hepatocytes. Administration of the non-opiate Leu-enkephalin analogue did not normalize gravimetric parameters and nucleolar apparatus parameters, however, it significantly increased the pool of proliferating hepatocytes...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27908784/cisplatin-induced-mitochondrial-dysfunction-is-associated-with-impaired-cognitive-function-in-rats
#7
Naomi Lomeli, Kaijun Di, Jennifer Czerniawski, John F Guzowski, Daniela A Bota
PURPOSE: Chemotherapy-related cognitive impairment (CRCI) is commonly reported following the administration of chemotherapeutic agents and comprises a wide variety of neurological problems. No effective treatments for CRCI are currently available. Here we examined the mechanisms involving cisplatin-induced hippocampal damage following cisplatin administration in a rat model and in cultured rat hippocampal neurons and neural stem/progenitor cells (NSC). We also assessed the protective effects of the antioxidant, N-acetylcysteine in mitigating these damages...
November 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27908757/synthesis-antioxidant-and-antichagasic-properties-of-a-selected-series-of-hydroxy-3-arylcoumarins
#8
Natalia Robledo-O'Ryan, Maria João Matos, Saleta Vazquez-Rodriguez, Lourdes Santana, Eugenio Uriarte, Mauricio Moncada-Basualto, Francisco Mura, Michel Lapier, Juan Diego Maya, Claudio Olea-Azar
Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents for the delay or abolishment of the progression of this pathology. In the current work, differently substituted hydroxy-3-arylcoumarins are described, exerting both antioxidant and trypanocidal activity. Among the compounds synthesized, compound 8 showed the most interesting profile, presenting a moderate scavenging ability for peroxyl radicals (ORAC-FL=2...
November 19, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27908717/biological-properties-of-water-soluble-polysaccharides-and-hemicelluloses-from-almond-gum
#9
Fatma Bouaziz, Mohamed Koubaa, Rhoudha Ellouz Ghorbel, Semia Ellouz Chaabouni
The aim of this work was to investigate the biological activities of almond gum polysaccharides (AGP) and almond gum hemicelluloses (AGH). Almond gum was first fractionated into AGP and AGH using hot water and alkaline solution, respectively. The antioxidant activities of both extracted polymers revealed interesting free radical scavenging activities through DPPH test (IC50 AGP=4mg/mL, IC50 AGH=6mg/mL), 2,2'-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS) radical scavenging activity test (% inhibition ABTS=40...
November 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27908582/effect-of-curcumin-on-kidney-histopathological-changes-lipid-peroxidation-and-total-antioxidant-capacity-of-serum-in-sodium-arsenite-treated-mice
#10
Hamid Reza Momeni, Najmeh Eskandari
Sodium arsenite is an environmental pollutant with the ability to generate free radicals and curcumin acts as a potent antioxidant. This study investigates the effect of curcumin on kidney histopathology, lipid peroxidation and antioxidant capacity of serum in the mice treated with sodium arsenite. Adult male mice were divided into four groups: control, sodium arsenite, curcumin and curcumin+sodium arsenite. The treatments were delivered for 5 weeks. After the treatment period, blood samples were collected and the concentrations of malondialdehyde (MDA) and total antioxidant capacity of serum were determined...
November 28, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27908553/olive-polyphenol-effects-in-a-mouse-model-of-chronic-ethanol-addiction
#11
Valentina Carito, Mauro Ceccanti, Vincenzo Cestari, Fausta Natella, Cristiano Bello, Roberto Coccurello, Rosanna Mancinelli, Marco Fiore
OBJECTIVES: Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress. METHODS: We administered (per os) for two months 20 mg/kg of olive polyphenols containing mostly hydroxytyrosol in alcoholic adult male mice. Hydroxytyrosol metabolites as hydroxytyrosol sulfate 1 and hydroxytyrosol sulfate 2 were found in the serum of mice administered with polyphenols with the highest amount in animals treated with both polyphenols and alcohol...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27908402/microwave-assisted-biosynthesis-of-zinc-nanoparticles-and-their-cytotoxic-and-antioxidant-activity
#12
Zeinab Salari, Atefeh Ameri, Hamid Forootanfar, Mahboubeh Adeli-Sardou, Mandana Jafari, Mitra Mehrabani, Mojtaba Shakibaie
The present study was designed for microwave assisted synthesis of zinc nanoparticles (Zn NPs) using Lavandula vera leaf extract in the presence of ZnSO4 (1mM). The biogenic Zn NPs were then characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction spectroscopy (XRD), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. Thereafter, the cytotoxic effect of ZnSO4 and Zn NPs on different cell lines was investigated by MTT-based cytotoxicity assay and their antioxidant properties were assessed using DPPH scavenging activity and reducing power assay...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908215/in-vitro-effect-of-myo-inositol-on-sperm-motility-in-normal-and-oligoasthenospermia-patients-undergoing-in-vitro-fertilization
#13
P G Artini, E Casarosa, E Carletti, P Monteleone, A Di Noia, O M Di Berardino
It is a known fact that abnormal seminal liquid specimens contain abnormal amounts of oxygen free radicals and reactive oxygen species (ROS), and that the use of antioxidant molecules both in vivo and in vitro leads to improvement of semen quality in terms of motility, reduction in DNA damage, with obvious consequences on the fertilization potential. Myo-inositol has been observed to have anti-oxidant properties and be present in much greater concentrations specifically in seminal liquid than in the blood. Moreover, there seems to be a direct relationship between myo-inositol and mitochondrial membrane potential (MMP) and sperm motility...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27907867/adsorption-characteristics-of-adsorbent-resins-and-antioxidant-capacity-for-enrichment-of-phenolics-from-two-phase-olive-waste
#14
Zhihong Wang, Chengzhang Wang, Jiaojiao Yuan, Changwei Zhang
In this study, the adsorption properties of nine resins including polyamide resin (30-60), polyamide resin (60-100) AB-8, S-8, D-101, NKA-9, NKA-II, XDA-1 and XDA-4 for enrichment phenolics of the olive waste were investigated. XDA-1 and NKA-II were chosen for further study due to their outstanding adsorption and desorption capacity. XDA-1 and NKA-II had similar adsorption and desorption behaviors for phenolics of olive waste. The adsorption mechanism could be better explained by pseudo second-order kinetics model and Freundlich isotherm model, and the adsorption processes were spontaneously and exothermic...
November 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27907185/antioxidant-antimicrobial-and-cytotoxic-properties-as-well-as-the-phenolic-content-of-the-extract-from-hancornia-speciosa-gomes
#15
Uilson P Santos, Jaqueline F Campos, Heron Fernandes V Torquato, Edgar Julian Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death...
2016: PloS One
https://www.readbyqxmd.com/read/27907152/dietary-probiotic-bacillus-subtilis-strain-fmbj-increases-antioxidant-capacity-and-oxidative-stability-of-chicken-breast-meat-during-storage
#16
Wen Kai Bai, Fei Jing Zhang, Tian Jin He, Peng Wei Su, Xiong Zhi Ying, Li Li Zhang, Tian Wang
This study was aimed to measure the dietary effects of probiotic Bacillus subtilis strain fmbj (BS fmbj) on antioxidant capacity and oxidative stability of chicken breast meat during storage. Treatment groups were fed the basal diet with BS fmbj at 0 g/kg (CON), 0.2 g/kg (BS-1), 0.3 g/kg (BS-2), or 0.4 g/kg (BS-3) doses without antibiotics. During 8 days of storage at 4°C, BS-2 group showed a significant improvement (P < 0.05) on meat quality (pH, Drip loss, Cooking loss, Shear force, color L*, a*, b*), free radical scavenging activity (DPPH, ABTS+, H2O2), tissues antioxidant enzyme capacity (SOD, CAT, GSH-Px, GSH, T-SH), mitochondria antioxidant enzyme capacity (MnSOD, GPx, GSH), mRNA expression of antioxidant genes (Nrf2, HO-1, SOD, CAT, GSH-Px) and mitochondrial function genes (avUCP, NRF1, NRF2, TFAM, PGC-1α), oxidative damage index (MDA, ROS, PC, 8-OHdG), and MMP level in chicken breast meat as compared to the CON group...
2016: PloS One
https://www.readbyqxmd.com/read/27907002/chemical-composition-an-antioxidant-cytotoxic-and-microbiological-activity-of-the-essential-oil-from-the-leaves-of-aeollanthus-suaveolens-mart-ex-spreng
#17
Rosany Lopes Martins, Ranggel Carvalho Simões, Érica de Menezes Rabelo, Ana Luzia Ferreira Farias, Alex Bruno Lobato Rodrigues, Ryan da Silva Ramos, João Batista Fernandes, Lourivaldo da Silva Santos, Sheylla Susan Moreira da Silva de Almeida
Aeollanthus suaveolens species popularly known as catinga de mulata belongs to the Lamiaceae family. In the Amazon region, it is used in folk medicine for the treatment of gastritis, convulsions of epileptic origin, stomach pain and diarrhea in the form of tea and juice. Essential oils have analgesic, anti-inflammatory, and antimicrobial activity. This study evaluated the chemical composition of the A. suaveolens essential oil, and its cytotoxic, antimicrobial and antioxidant activity on Artemia salina Leach...
2016: PloS One
https://www.readbyqxmd.com/read/27906609/glyphosate-adversely-affects-danio-rerio-males-acetylcholinesterase-modulation-and-oxidative-stress
#18
Fernanda Moreira Lopes, Sergiane Souza Caldas, Ednei Gilberto Primel, Carlos Eduardo da Rosa
It has been demonstrated that glyphosate-based herbicides are toxic to animals. In the present study, reactive oxygen species (ROS) generation, antioxidant capacity against peroxyl radicals (ACAP), and lipid peroxidation (LPO), as well as the activity and expression of the acetylcholinesterase (AChE) enzyme, were evaluated in Danio rerio males exposed to 5 or 10 mg/L of glyphosate for 24 and 96 h. An increase in ACAP in gills after 24 h was observed in the animals exposed to 5 mg/L of glyphosate. A decrease in LPO was observed in brain tissue of animals exposed to 10 mg/L after 24 h, while an increase was observed in muscle after 96 h...
December 1, 2016: Zebrafish
https://www.readbyqxmd.com/read/27906147/biogenic-synthesis-of-silver-nanoparticles-from-cassia-fistula-linn-in-vitro-assessment-of-their-antioxidant-antimicrobial-and-cytotoxic-activities
#19
Yugal Kishore Mohanta, Sujogya Kumar Panda, Kunal Biswas, Abiral Tamang, Jaya Bandyopadhyay, Debashis De, Dambarudhar Mohanta, Akshaya Kumar Bastia
The present study reports on biogenic-synthesised silver nanoparticles (AgNPs) derived by treating Ag ions with an extract of Cassia fistula leaf, a popular Indian medicinal plant found in natural habitation. The progress of biogenic synthesis was monitored time to time using a ultraviolet-visible spectroscopy. The effect of phytochemicals present in C. fistula including flavonoids, tannins, phenolic compounds and alkaloids on the homogeneous growth of AgNPs was investigated by Fourier-transform infrared spectroscopy...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27906145/nitrobacter-sp-extract-mediated-biosynthesis-of-ag2o-nps-with-excellent-antioxidant-and-antibacterial-potential-for-biomedical-application
#20
Gopalu Karunakaran, Matheswaran Jagathambal, Alexander Gusev, Nguyen Van Minh, Evgeny Kolesnikov, Arup Ratan Mandal, Denis Kuznetsov
In this study, extracellular extract of plant growth promoting bacterium, Nitrobacter sp. is used for the bioconversion of AgNO3 (silver nitrate) into Ag2O (silver oxide nanoparticles). It is an easy, ecofriendly and single step method for Ag2O NPs synthesis. The bio-synthesized nanoparticles were characterized using different techniques. UV-Vis results showed the maximum absorbance around 450 nm. XRD result shows the particles to have faced centered cubic (fcc) crystalline nature. FTIR analysis reveals the functional groups that are involved in bioconversion such as C-N, N-H and C=O...
December 2016: IET Nanobiotechnology
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