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https://www.readbyqxmd.com/read/28346285/effect-of-early-revascularization-on-outcomes-in-diabetic-patients-with-stable-ischemic-heart-disease-and-previous-myocardial-infarction-in-the-bypass-angioplasty-investigation-2-diabetes-trial
#1
Matthew J Chung, Eric Novak, David L Brown
BACKGROUND: Survivors of a myocardial infarction (MI) are at a considerable risk of developing further cardiovascular events, including recurrent MI, heart failure, stroke, and death. Patients with type 2 diabetes mellitus and stable ischemic heart disease (SIHD) have worse outcomes than their nondiabetic counterparts, and those with previous MI may be at particularly high risk. Yet, little is known about the effect of adding early revascularization to intensive medical therapy in this high-risk group...
March 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28346284/an-electronic-cardiac-rehabilitation-referral-system-increases-cardiac-rehabilitation-referrals
#2
James P Pirruccello, Kathleen C Traynor, Pradeep Natarajan, Carol Brown, Michael K Hidrue, Kenneth A Rosenfield, Sekar Kathiresan, Jason H Wasfy
AIM: Although cardiac rehabilitation attendance is associated with improved clinical outcomes for patients after acute myocardial infarction (AMI), it remains underutilized nationally. We sought to determine whether replacing traditional, paper-based referrals for cardiac rehabilitation for patients with AMI with an electronic referral system would increase utilization. METHODS AND RESULTS: We implemented the change from traditional, paper-based referrals to electronic referrals at the Massachusetts General Hospital on 10 December 2013...
March 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28346238/management-of-hypertension-in-2017-targets-and-therapies
#3
Monica Ahluwalia, Sripal Bangalore
PURPOSE OF REVIEW: Approximately one-fourth of the adult population is diagnosed with hypertension, which has been associated with increased cardiovascular morbidity and mortality including cardiovascular death, myocardial infarction, heart failure and stroke. Early detection and treatment is a key and can lead to a significant reduction in cardiovascular morbidity and mortality. RECENT FINDINGS: In this review, we discuss the management and treatment strategies in patients with hypertension in the current era...
March 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28345953/reperfusion-ventricular-arrhythmia-bursts-identify-larger-infarct-size-in-spite-of-optimal-epicardial-and-microvascular-reperfusion-using-cardiac-magnetic-resonance-imaging
#4
Kirian van der Weg, Wichert J Kuijt, Sebastiaan Cam Bekkers, Jan Gp Tijssen, Cynthia L Green, Miguel E Lemmert, Mitchell W Krucoff, Anton Pm Gorgels
AIMS: Ventricular arrhythmia (VA) bursts following recanalisation in acute ST-elevation myocardial infarction (STEMI) are related to larger infarct size (IS). Inadequate microvascular reperfusion, as determined by microvascular obstruction (MVO) using cardiac magnetic resonance imaging (CMR), is also known to be associated with larger IS. This study aimed to test the hypothesis that VA bursts identify larger infarct size in spite of optimal microvascular reperfusion. METHODS: All 65 STEMI patients from the Maastricht ST elevation (MAST) study with brisk epicardial flow (TIMI 3), complete ST recovery post-percutaneous coronary intervention and early CMR were included...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28345679/impact-of-climate-conditions-on-hospital-admissions-for-subcategories-of-cardiovascular-diseases
#5
Sanja Bijelović, Nataša Dragić, Milorad Bijelović, Mila Kovačević, Marija Jevtić, Olivera Ninkovic Mrđenovački
BACKGROUND: The aim of this study has been to examine the association between climate conditions (CC) and hospital admissions for the subcategories of cardiovascular diseases (CVD), according to patients' age. MATERIAL AND METHODS: From January 2010 through December 2011, the daily number of hospital admissions for angina pectoris (AP), essential hypertension (EH), acute myocardial infarction (AMI) and ischemic heart diseases (IHD) for adults (19-64 years old) and the elderly (≥ 65 years old), as well as for the CC (N = 728 days) was collected for multivariate Poisson regression analysis, confounding with season and weekends...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345539/admission-glucose-and-in-hospital-mortality-after-acute-myocardial-infarction-in-patients-with-or-without-diabetes-a-cross-sectional-study
#6
Shi Zhao, Karthik Murugiah, Na Li, Xi Li, Zi-Hui Xu, Jing Li, Chen Cheng, Hong Mao, Nicholas S Downing, Harlan M Krumholz, Li-Xin Jiang
BACKGROUND: Hyperglycemia on admission has been found to elevate risk for mortality and adverse clinical events after acute myocardial infarction (AMI), but there are evidences that the relationship of blood glucose and mortality may differ between diabetic and nondiabetic patients. Prior studies in China have provided mixed results and are limited by statistical power. Here, we used data from a large, nationally representative sample of patients hospitalized with AMI in China in 2001, 2006, and 2011 to assess if admission glucose is of prognostic value in China and if this relationship differs depending on the presence or absence of diabetes...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345538/current-trends-for-st-segment-elevation-myocardial-infarction-during-the-past-5-years-in-rural-areas-of-china-s-liaoning-province-a-multicenter-study
#7
Guang-Xiao Li, Bo Zhou, Guo-Xian Qi, Bo Zhang, Da-Ming Jiang, Gui-Mei Wu, Bing Ma, Peng Zhang, Qiong-Rui Zhao, Juan Li, Ying Li, Jing-Pu Shi
BACKGROUND: Since 2010, two versions of National Guidelines aimed at promoting the management of ST-segment elevation myocardial infarction (STEMI) have been formulated by the Chinese Society of Cardiology. However, little is known about the changes in clinical characteristics, management, and in-hospital outcomes in rural areas. METHODS: In the present multicenter, cross-sectional study, participants were enrolled from rural hospitals located in Liaoning province in Northeast China, during two different periods (from June 2009 to June 2010 and from January 2015 to December 2015)...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345491/a-comparison-of-toxicities-in-acute-myeloid-leukemia-patients-with-and-without-renal-impairment-treated-with-decitabine
#8
Lauren B Levine, Julianna Vf Roddy, Miryoung Kim, Junan Li, Gary Phillips, Alison R Walker
Purpose There are limited data regarding the clinical use of decitabine for the treatment of acute myeloid leukemia in patients with a serum creatinine of 2 mg/dL or greater. Methods We retrospectively evaluated 111 patients with acute myeloid leukemia who had been treated with decitabine and compared the development of toxicities during cycle 1 in those with normal renal function (creatinine clearance greater than or equal to 60 mL/min) to those with renal dysfunction (creatinine clearance less than 60 mL/min)...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28345366/reply-to-commentary-on-history-of-erectile-dysfunction-as-a-predictor-of-poor-physical-performance-after-an-acute-myocardial-infarction
#9
Leonida Compostella, Li Van Stella Truong, Caterina Compostella
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28345355/coronary-spasm-secondary-to-cefuroxime-injection-complicated-with-cardiogenic-shock-a-manifestation-of-kounis-syndrome-case-report-and-literature-review
#10
Andreas Mitsis, Evi Christodoulou, Panayiota Georgiou
Kounis syndrome is defined as the coincidental occurrence of an acute coronary syndrome with hypersensitivity reactions following an allergic event. The three reported variants of Kounis syndrome are vasospastic allergic angina, allergic myocardial infarction and stent thrombosis with occluding thrombus. The syndrome is caused by various inflammatory mediators. The pathophysiological characteristics of Kounis syndrome involve coronary artery spasm and/or atheromatous plaque erosion or rupture during an allergic reaction...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28345154/outcomes-in-post-myocardial-infarction-patients-similar-to-those-of-the-pegasus-timi-54-trial-a-cohort-study-in-the-french-national-claims-database
#11
Patrick Blin, Caroline Dureau-Pournin, Régis Lassalle, Jérémy Jové, Florence Thomas-Delecourt, Cécile Droz-Perroteau, Nicolas Danchin, Nicholas Moore
AIMS: The present study aims to describe real-life outcomes in stable post-myocardial infarction (MI) patients similar to those in the PEGASUS-TIMI 54 trial (PEGASUS), which found long-term benefits of ticagrelor in patients with a history of MI. METHODS: One-year event-free post-MI patients were identified in the French claims database representative 1/97 sample (2005-2010) and followed up to 3 years. A PEGASUS-like (PL) population included patients with age ≥ 65 years, or age ≥50 and diabetes, renal dysfunction or prior MI, without stroke, end-stage renal failure or oral anticoagulation...
March 26, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28345145/air-pollution-and-short-term-clinical-outcomes-of-patients-with-acute-myocardial-infarction
#12
Min Woo Lee, Byoung Geol Choi, Suhng Wook Kim, Seung-Woon Rha, Min Suk Shim, Dae Jin Kim, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong
1.Ambient air pollution is well-known to be a serious risk factor for cardiovascular diseases, stroke, and death. However, the association between air pollutants (AP) exposure and short-term clinical outcomes in acute myocardial infarction (AMI) patients (pts) is not well elucidated yet. 2.In the present study, 37,880 AMI pts were enrolled finally from October 2005 to December 2013 in a nationwide large-scale, prospective, multicenter Korea AMI registry (KAMIR registry; http://www.kamir.or.kr). We obtained data on AP (e...
March 27, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28345068/how-much-risk-are-emergency-department-patients-willing-to-accept-to-avoid-diagnostic-testing
#13
Jeremy Padalecki, K Tom Xu, Cynthia Smith, Lynn Carrasco, Justin Hensley, Peter B Richman
OBJECTIVES: There is a paucity of research evaluating the risk tolerance of Emergency Department (ED) patients. We hypothesized that a significant percentage of ED patients surveyed would be comfortable with ≥5% risk of adverse outcome if they avoided testing in several hypothetical scenarios. MATERIALS AND METHODS: This was a cross-sectional study of a convenience sample of stable inner-city ED patients. Patients completed a written survey and were asked four closed-answer questions regarding risk tolerance/willingness to refuse a test/procedure, including the following scenarios: #1: LP following CT head; #2 overnight serial troponins for rule out myocardial infarction; #3 CT for possible appendicitis, #4 parent deciding whether child should undergo head CT for low risk head injury...
March 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28344980/discordance-in-investigator-reported-and-adjudicated-sudden-death-in-tiospir
#14
Robert A Wise, Peter R Kowey, George Austen, Achim Mueller, Norbert Metzdorf, Andy Fowler, Lorcan P McGarvey
Accurate and consistent determination of cause of death is challenging in chronic obstructive pulmonary disease (COPD) patients. TIOSPIR (N=17 135) compared the safety and efficacy of tiotropium Respimat 5/2.5 µg with HandiHaler 18 µg in COPD patients. All-cause mortality was a primary end-point. A mortality adjudication committee (MAC) assessed all deaths. We aimed to investigate causes of discordance in investigator-reported and MAC-adjudicated causes of death and their impact on results, especially cardiac and sudden death...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28344738/adherence-to-exercise-prescription-and-improvements-in-the-clinical-and-vascular-health-of-african-americans
#15
Dianne M Babbitt, Amanda M Perkins, Keith M Diaz, Deborah L Feairheller, Kathleen M Sturgeon, Praveen Veerabhadrappa, Sheara T Williamson, Jan Kretzschmar, Chenyi Ling, Hojun Lee, Heather Grim, Michael D Brown
Improvements in indices of vascular health and endothelial function have been inversely associated with hypertension, a risk factor for cardiovascular disease (e.g., myocardial infarction, stroke, and heart failure), renal failure, and mortality. Aerobic exercise training (AEXT) has been positively associated with improvements in clinical health values, as well as vascular health biomarkers, and endothelial function. The purpose of this study was to evaluate whether measures of exercise adherence were related to clinical outcome measures and indices of vascular health subsequent to a 6-month AEXT intervention in a middle-to-older aged African American cohort...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28344659/comparison-of-in-hospital-glycemic-variability-and-admission-blood-glucose-in-predicting-short-term-outcomes-in-non-diabetes-patients-with-st-elevation-myocardial-infarction-underwent-percutaneous-coronary-intervention
#16
Shu-Hua Mi, Gong Su, Hong-Xia Yang, Yun Zhou, Lei Tian, Tao Zhang, Hong Tao
AIMS: Admission hyperglycemia is associated with increased mortality and major adverse cardiac events (MACE) in patients with or without diabetes mellitus after acute myocardial infarction (AMI). However, effects of glycemic variability (GV) on outcomes of non-diabetes patients with AMI still remains unclear. The aim of this study is to compare the prognostic value of in-hospital GV with admission blood glucose (ABG) for 3-month MACE in non-diabetes patients with ST elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28344655/interactions-among-cox-2-gpiiia-and-p2y1-variants-are-associated-with-aspirin-responsiveness-and-adverse-events-in-patients-with-ischemic-stroke
#17
Xingyang Yi, Zhao Han, Qiang Zhou, Jing Lin, Chun Wang
BACKGROUND: The effect of gene variants and their interactions on response to aspirin and clinical adverse outcomes after an acute ischemic stroke (IS) is not fully understood. The aim of this study was to investigate the association of aspirin-relevant gene variants and their interactions with clinical adverse outcomes in IS patients taking aspirin. METHODS: A total of 14 variants from six genes encoding COX enzymes (COX-1, COX-2), platelet membrane receptors (TXAS1, P2Y1, P2Y12) and glycoprotein receptor (GPIIIa) were examined in 850 acute IS patients...
March 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28344618/patient-and-lesion-tailored-algorithm-of-endovascular-treatment-for-arterial-occlusive-disease-of-extracranial-arteries-supplying-the-brain-safety-of-the-treatment-at-30-day-follow-up
#18
Paweł Latacz, Marian Simka, Paweł Brzegowy, Piotr Janas, Marek Kazibudzki, Piotr Pieniążek, Andrzej Ochała, Tadeusz Popiela, Tomasz Mrowiecki
INTRODUCTION: Although surgical endarterectomy remains the treatment of choice for carotid artery stenosis, stenting plays an important role as an alternative treatment modality, especially in high-risk patients. The actual safety profile associated with stenting procedures is probably better than that reported by randomized controlled trials. AIM: To assess the safety of stent implantations in extracranial arteries supplying the brain, and also to identify risk factors associated with this procedure...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344616/the-impact-of-a-single-episode-of-remote-ischemic-preconditioning-on-myocardial-injury-after-elective-percutaneous-coronary-intervention
#19
Mustafa A Yılmaztepe, Gökay Taylan, Meryem Aktoz, Hanefi Y Gürlertop, Yüksel Aksoy, Fatih Özçelik, Kenan Yalta, Galip Ekuklu
INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344415/percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-in-patients-with-diabetic-nephropathy-and-left-main-coronary-artery-disease
#20
Hsin-Ru Li, Chiao-Po Hsu, Shih-Hsien Sung, Chun-Che Shih, Shing-Jong Lin, Wan-Leong Chan, Cheng-Hsueh Wu, Tse-Min Lu
BACKGROUND: Patients with diabetic nephropathy and unprotected left main (LM) coronary artery disease suffer from high cardiovascular morbidity and mortality. Although surgical revascularization is currently recommended in this special patient population, the optimal revascularization method for this distinct patient group has remained unclear. METHODS: We collected 99 consecutive patients with unprotected LM disease and diabetic nephropathy, including 46 patients who had undergone percutaneous coronary intervention (PCI), and 53 who had coronary artery bypass grafting (CABG), with a mean age of 72 ± 10; with 80...
March 2017: Acta Cardiologica Sinica
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