keyword
https://read.qxmd.com/read/38535530/an-unusual-case-of-serologically-confirmed-post-partum-lyme-disease-following-an-asymptomatic-borrelia-burgdorferi-infection-acquired-during-pregnancy-and-lacking-vertical-transmission-in-utero
#1
Charles S Pavia, Maria M Plummer, Alena Varantsova
In this report, we describe a 23-year-old female who, while pregnant, was exposed to Borrelia burgdorferi but did not develop significant signs or symptoms (joint pain, arthritis) of Lyme disease until shortly after delivering a healthy child at term. Serologic testing confirmed infection with B. burgdorferi . A 3-week course of treatment with doxycycline was completely curative. There was no evidence for congenital or perinatal transmission of this pathogen at any point pre-term or postnatally. The key reasons that could account for this unique clinical scenario are discussed in the context of previously published related reports...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38534880/successful-bone-marrow-transplantation-in-a-patient-with-acute-myeloid-leukemia-developed-from-severe-congenital-neutropenia-using-modified-chemotherapy-and-conditioning-regimen-for-leukemia
#2
Risa Matsumura, Shinji Mochizuki, Yusuke Morishita, Hiroko Hayakawa, Shuhei Karakawa, Hiroshi Kawaguchi, Satoshi Okada, Nobuyuki Hyakuna, Masao Kobayashi
Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with SCN who develop myelodysplastic syndrome/AML. We report an 8-year-old girl with SCN carrying an ELANE mutation that had been refractory to granulocyte colony-stimulating factor. The patient experienced recurrent infections and then developed AML...
February 26, 2024: Hematology Reports
https://read.qxmd.com/read/38529529/estimated-cytomegalovirus-seroprevalence-in-the-general-population-of-the-united-states-and-canada
#3
JOURNAL ARTICLE
W Dana Flanders, Cathy Lally, Anne Dilley, John Diaz-Decaro
Seroprevalence data for cytomegalovirus (CMV), a widespread virus causing lifelong infection, vary widely, and contemporary data from the United States (US) and Canada are limited. Utilizing a modeling approach based on a literature review (conducted August, 2022) of data published since 2005, we determine age-, sex-, and country-specific CMV seroprevalence in the general US and Canadian populations. Sex-specific data were extracted by age categories, and a random-effects meta-regression model was used to fit the reported data (incorporating splines for the US)...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38528616/clinical-and-economic-burden-of-respiratory-syncytial-virus-in-children-aged-0-5-years-in-italy
#4
JOURNAL ARTICLE
Melania Dovizio, Chiara Veronesi, Fausto Bartolini, Arturo Cavaliere, Stefano Grego, Romina Pagliaro, Cataldo Procacci, Loredana Ubertazzo, Lorenzo Bertizzolo, Barbara Muzii, Salvatore Parisi, Valentina Perrone, Eugenio Baraldi, Elena Bozzola, Fabio Mosca, Luca Degli Esposti
BACKGROUND: Respiratory syncytial virus (RSV) is among the leading causes of hospitalization due to lower respiratory tract infections (LRTIs) in children younger than 5 years worldwide and the second cause of infant death after malaria. RSV infection occurs in almost all the infants before the second year of life with variable clinical severity, often requiring medical assistance. This analysis investigated patients aged 0-5 years with RSV infection focusing on epidemiology, clinical features, and economic burden of RSV-associated hospitalizations in a setting of Italian real clinical practice...
March 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38528568/an-epidemiological-investigation-of-high-risk-infants-for-respiratory-syncytial-virus-infections-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Michela Servadio, Marco Finocchietti, Chiara Vassallo, Riccardo Cipelli, Franca Heiman, Giulia Di Lucchio, Bianca Oresta, Antonio Addis, Valeria Belleudi
BACKGROUND: Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the influence of different gestational age (WGA) and concomitant specific comorbidities on the burden of RSV infections are scarce, the present study aimed to better characterize these high-risk populations in the Italian context...
March 25, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38527603/contribution-of-fetal-blood-sampling-to-determining-the-prognosis-of-congenital-cytomegalovirus-infections-a-case-cohort-study-in-switzerland
#6
JOURNAL ARTICLE
Léo Pomar, Agathe Contier, Milos Stojanov, Cécile Guenot, Joanna Sichitiu, Anita C Truttmann, Yvan Vial, David Baud
BACKGROUND: Cytomegalovirus is responsible for the most common congenital infection, affecting 0.5-1% of live births in Europe. Congenital CMV infection can be diagnosed during pregnancy by viral DNA amplification in the amniotic fluid, but the prognosis of fetuses without severe brain abnormalities remains difficult to establish based on prenatal imaging alone. OBJECTIVES: To identify predictors of moderate to severe symptomatic CMV infection among fetal blood parameters, and to propose an algorithm based on these parameters and on prenatal imaging that would provide the best positive and negative predictive values...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38527352/an-analysis-of-the-efficacy-of-multilayered-repair-and-reconstruction-using-combined-tissue-pedicle-flaps-for-abdominal-wall-defects-in-adult-bladder-exstrophy-patients
#7
JOURNAL ARTICLE
Baihetiya Azhati, Diliyaer Dilixiati, Aerziguli Reheman, Wentao Li, Yang Yu
OBJECTIVE: In this study, we conducted a retrospective analysis of cases involving adult classic bladder exstrophy (CBE) accompanied by the absence of the abdominal wall. Specifically, we focused on the utilization of multilayer flaps for reconstructive purposes. In addition, we aimed to share our clinical treatment experience pertaining to similar challenges, thereby providing valuable insights to complement the surgical management of this rare disease. METHODS: We conducted a retrospective analysis of 12 adult patients diagnosed with CBE who underwent initial treatment between June 2013 and January 2020...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38524771/familial-congenital-lower-urinary-tract-obstruction-luto-suggested-by-screening-for-lower-urinary-tract-dysfunction-in-parents-of-patients-a-descriptive-study
#8
JOURNAL ARTICLE
Fabian Ebach, Pauline Wagner, Raimund Stein, Ramona Dolscheid-Pommerich, Heiko Reutter, Alina C Hilger
BACKGROUND: Congenital lower urinary tract obstruction (LUTO) describes a heterogeneous group of congenital malformations. Posterior urethral valves (PUV) represent the most common entity. Familial occurrence has been described, suggestive of underlying genetic factors. LUTO can occur in various degrees of severity. In severe forms, oligohydramnios, pulmonary hypoplasia, and renal damage can occur resulting in high pre- and postnatal mortality. On the contrary, mild forms may become apparent through recurrent urinary tract infections...
March 2024: Health Science Reports
https://read.qxmd.com/read/38524725/bone-regenerate-evaluation-methods
#9
JOURNAL ARTICLE
Gracielle Silva Cardoso, Renato Amorim
Since its introduction by Ilizarov, the distraction osteogenesis technique has been used to treat trauma-related conditions, infections, bone tumors, and congenital diseases, either as methods of bone transport or elongation. One of the major dilemmas for the orthopedic surgeon who performs osteogenic distraction is establishing a reproducible method of assessing the progression of the osteogenesis, enabling the early detection of regenerate failures, in order to effectively interfere during treatment, and to determine the appropriate time to remove the external fixator...
February 2024: Revista Brasileira de Ortopedia
https://read.qxmd.com/read/38523883/caroli-s-disease-associated-with-autosomal-dominant-polycystic-kidney-disease-with-acute-pancreatitis-a-case-report
#10
Karishma M Rathi, Priyanka Pingat, Prachi Bansode, Shaili Dongare
A rare congenital hepatobiliary disorder called Caroli's disease is characterized by multifocal segmental dilatation of intrahepatic bile ducts that can affect the entire liver or only specific areas of it. Coexisting conditions with Caroli's disease include autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD). ADPKD results in the development of cysts, which are tiny fluid-filled sacs, in the kidneys. Caroli's disease is considered a rare disorder, affecting a small number of individuals worldwide...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38523441/cilia-and-nodal-flow-in-asymmetry-an-engineering-perspective
#11
JOURNAL ARTICLE
Madisyn Messmore, Alain J Kassab, Ray O Prather, David A Castillo Arceo, William DeCampli
Over the past several years, cilia in the primitive node have become recognized more and more for their contribution to development, and more specifically, for their role in axis determination. Although many of the mechanisms behind their influence remain undocumented, it is known that their presence and motion in the primitive node of developing embryos is the determinant of the left-right axis. Studies on cilial mechanics and nodal fluid dynamics have provided clues as to how this asymmetry mechanism works, and more importantly, have shown that direct manipulation of the flow field in the node can directly influence physiology...
2024: Critical Reviews in Biomedical Engineering
https://read.qxmd.com/read/38522873/long-term-outcomes-of-mechanical-aortic-valve-replacement-in-children
#12
REVIEW
Michael Z L Zhu, Edward Buratto, Damien M Wu, Shuta Ishigami, Antonia Schulz, Christian P Brizard, Igor E Konstantinov
When the options of aortic valve repair or the Ross procedure are not feasible or have been exhausted, mechanical aortic valve replacement (AVR) may provide a reliable and structurally durable alternative, but with the limitations of long-term anticoagulation, thrombosis risk and lack of valve growth potential. In this article, we review the longitudinal outcomes of mechanical AVR in children in our institution and compare them to those recently reported by others. From 1978 to 2020, 62 patients underwent mechanical AVR at a median age of 12...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38522429/the-efficacy-of-nursing-interventions-in-preventing-surgical-site-infections-in-patients-undergoing-surgery-for-congenital-heart-disease
#13
JOURNAL ARTICLE
Ping He, Yue Hai
Surgical site infections (SSIs) pose significant risks to patients undergoing surgery for congenital heart disease (CHD), impacting recovery and increasing healthcare burdens. This study assesses the efficacy of targeted nursing interventions in reducing SSIs and enhancing wound healing in this vulnerable patient group. A prospective cohort study was conducted from January 2022 to August 2023 at a single institution, involving 120 paediatric patients divided into control (standard postoperative care) and observation (specialized nursing interventions) groups...
April 2024: International Wound Journal
https://read.qxmd.com/read/38521911/clinical-application-of-middle-descending-colon-double-lumen-ostomy-with-distal-stoma-narrowing-in-the-treatment-of-anorectal-malformation
#14
JOURNAL ARTICLE
Guoxian Huang, Wenni Li, Lili Ma, Xin Lei, Xiangde Lin, Yuandong Chen, Bo Xu
BACKGROUND: Anorectal malformations (ARMs) are the most common congenital anomaly of the digestive tract. And colostomy should be performed as the first-stage procedure in neonates diagnosed with intermediate- or high-type ARMs. However, the most classic Pe˜na's colostomy still has some disadvantages such as complicated operation procedure, susceptibility to infection, a greater possibility of postoperative incision dehiscence, difficulty of nursing and large surgical trauma and incision scarring when closing the stoma...
March 23, 2024: BMC Pediatrics
https://read.qxmd.com/read/38521832/in-vitro-hemodynamic-performance-of-a-blood-pump-for-self-powered-venous-assist-in-univentricular-hearts
#15
JOURNAL ARTICLE
Reza Rasooli, Henrik Holmstrom, Knut Erik Teigen Giljarhus, Ingunn Westvik Jolma, Jan Ludvig Vinningland, Charlotte de Lange, Henrik Brun, Aksel Hiorth
Univentricular heart anomalies represent a group of severe congenital heart defects necessitating early surgical intervention in infancy. The Fontan procedure, the final stage of single-ventricle palliation, establishes a serial connection between systemic and pulmonary circulation by channeling venous return to the lungs. The absence of the subpulmonary ventricle in this peculiar circulation progressively eventuates in failure, primarily due to chronic elevation in inferior vena cava (IVC) pressure. This study experimentally validates the effectiveness of an intracorporeally-powered venous ejector pump (VEP) in reducing IVC pressure in Fontan patients...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38520228/environmental-risk-factors-protective-factors-and-biomarkers-for-hearing-loss-an-umbrella-review
#16
REVIEW
Xianpeng Xu, Yiru Liao, Lihong Zhang, Yu He, Ying Zhang, Dajing Xiong, Hui Xie
OBJECTIVE: We aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence. DATA SOURCES: Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023. REVIEW METHODS: We included meta-analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers...
March 23, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38518531/outcomes-of-prolonged-open-abdomen-in-children
#17
JOURNAL ARTICLE
Brianna L Spencer, Dimitra M Lotakis, Jessica Carducci, Lauren Hoff, Devon Gingrich, Samir K Gadepalli, K Elizabeth Speck
INTRODUCTION: We sought to better characterize outcomes in pediatric patients requiring open abdomen for instability with ongoing resuscitation, second look surgery, or left in discontinuity or congenital or acquired loss of domain that may lead to prolonged open abdomen (POA) or difficulties in successful abdominal wall closure. METHODS: We performed a single-institution retrospective review of patients aged less or equal to 18 years who presented to our institution from 2015 to 2022...
March 21, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38518044/analysis-and-risk-factors-of-deep-vein-catheterization-related-bloodstream-infections-in-neonates
#18
JOURNAL ARTICLE
Yan Zhang, Shufang Li, Yanmin Li, Jiaojiao Zheng, Yaping Dong
To investigate the incidence, risk factors, and pathogenic characteristics of catheter-related bloodstream infection caused by peripherally inserted central venous catheter in neonates, and to provide references for reducing the infection rate of peripherally inserted central venous catheter. The clinical data of 680 neonates who underwent peripherally inserted central catheter (PICC) in the neonatal intensive care unit from June 2020 to June 2023 were retrospectively analyzed. The risk factors and independent risk factors of catheter-related bloodstream infection caused by PICC were determined by univariate and multivariate analysis, respectively...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38515475/perinatal-characteristics-and-longer-term-outcomes-in-brazilian-children-with-confirmed-or-suspected-congenital-zika-infection-zikaction-paediatric-registry
#19
JOURNAL ARTICLE
Isadora Cristina de Siqueira, Breno Lima de Almeida, Maria Lucia Costa Lage, Leticia Serra, Alessandra Carvalho, Maricélia Maia de Lima, Maria de Fatima Neri Góes, Marília De Santa Inês Neri Crispim, Mirela Monteiro da Costa Pereira, Bernardo Gratival Gouvea Costa, Heather Bailey, Thomas Byrne, Carlo Giaquinto, Georgina Fernandes, Elisa Ruiz-Burga, Claire Thorne
BACKGROUND: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS). METHODS: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review...
December 2023: Dialogues Health
https://read.qxmd.com/read/38515067/has-zika-been-forgotten-a-qualitative-exploration-of-knowledge-gaps-perceived-risk-and-preventive-practices-in-pregnant-women-in-malaysia
#20
JOURNAL ARTICLE
Li Ping Wong, Haridah Alias, Hai Yen Lee, Sazaly AbuBakar, Yulan Lin, Zhijian Hu
BACKGROUND: Although Zika virus infection is rarely reported now, continuous prevention is needed to achieve sustained eradication. This study aimed to explore the knowledge gaps, risk perception and preventive measures against Zika virus infection (ZIKV) in pregnant women in Malaysia. METHODS: We conducted in-depth virtual interviews with pregnant women between February and April 2022. The interviews were recorded and transcribed, and data were analyzed by content analysis...
March 21, 2024: BMC Women's Health
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