X Kang, X Xiao, M Harata, Y Bai, Y Nakazaki, Y Soda, R Kurita, T Tanaka, F Komine, K Izawa, R Kunisaki, M Setoyama, H Nishimori, A Natsume, M Sunamura, L Lozonshi, I Saitoh, T Tokino, S Asano, Y Nakamura, K Tani
Glioblastomas are the most common primary brain tumors in adults. These tumors exhibit a high degree of vascularization, and malignant progression from astrocytoma to glioblastoma is often accompanied by increased angiogenesis and the upregulation of vascular endothelial growth factor and its receptors. In this study, we investigated the in vivo antiangiogenic and antitumor effects of brain-specific angiogenesis inhibitor 1 (BAI1) using human glioblastoma cell lines. Glioblastoma cells were transduced with an adenoviral vector encoding BAI1 (AdBAI1), and Northern and Western blot analyses, respectively, demonstrated BAI1 mRNA and protein expression in the transduced tumor cells...
April 2006: Cancer Gene Therapy