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https://www.readbyqxmd.com/read/28647440/optimal-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-and-multivessel-disease-an-updated-large-scale-systematic-review-and-meta-analysis
#1
An Vu Nguyen, Le Van Thanh, Mohamed Gomaa Kamel, Sara Attia Mahmoud Abdelrahman, Mohamed El-Mekawy, Mohamed Ashraf Mokhtar, Aya Ashraf Ali, Nam Nguyen Nho Hoang, Nguyen Lam Vuong, Fatma Abd-Elshahed Abd-Elhay, Omer Abdelbagi Omer, Ahmed Abdou Mohamed, Kenji Hirayama, Nguyen Tien Huy
BACKGROUND: Our study aimed to compare three different percutaneous coronary intervention (PCI) approaches: culprit-only (COR) and complete (CR) revascularization - categorizing into immediate (ICR) or staged (SCR). METHODS: We searched 13 databases for randomized controlled trials. Articles were included if they compared at least two strategies. To have more studies in each analysis, an adjusted analysis was performed using person-years to incorporate follow-up durations and obtain pooled rate ratios (RR), with their corresponding 95% confidence interval...
June 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28646767/enhanced-photodegradation-of-2-4-dichlorophenoxyacetic-acid-using-a-novel-tio2-mgfe2o4-core-shell-structure
#2
Bui The Huy, Da-Som Jung, Nguyen Thi Kim Phuong, Yong-Ill Lee
A novel TiO2@MgO-Fe2O3 core-shell structure has been synthesized via a hydrolysis and co-precipitation method followed by calcination at 500 °C and has proven to be an efficient photocatalyst. The obtained TiO2@MgO-Fe2O3 core-shell was characterized by scanning electron microscopy, X-ray diffraction, and UV-Vis diffused reflectance techniques. Its photocatalytic activity toward 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated in aqueous solutions with and without visible light irradiation in the presence and absence of hydrogen peroxide...
June 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28646526/adamts13-test-and-or-plasmic-clinical-score-in-management-of-acquired-thrombotic-thrombocytopenic-purpura-a-cost-effective-analysis
#3
Chong H Kim, Sierra C Simmons, Lance A Williams Iii, Elizabeth M Staley, X Long Zheng, Huy P Pham
BACKGROUND: The ADAMTS13 test distinguishes thrombotic thrombocytopenic purpura (TTP) from other thrombotic microangiopathies (TMAs). The PLASMIC score helps determine the pretest probability of ADAMTS13 deficiency. Due to inherent limitations of both tests, and potential adverse effects and cost of unnecessary treatments, we performed a cost-effectiveness analysis (CEA) investigating the benefits of incorporating an in-hospital ADAMTS13 test and/or PLASMIC score into our clinical practice...
June 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28642701/the-market-of-biopharmaceutical-medicines-a-snapshot-of-a-diverse-industrial-landscape
#4
Evelien Moorkens, Nicolas Meuwissen, Isabelle Huys, Paul Declerck, Arnold G Vulto, Steven Simoens
Background: Biopharmaceutical medicines represent a growing share of the global pharmaceutical market, and with many of these biopharmaceutical products facing loss of exclusivity rights, also biosimilars may now enter the biopharmaceutical market. Objectives: This study aims to identify and document which investment and development strategies are adopted by industrial players in the global biopharmaceutical market. Methods: A descriptive analysis was undertaken of the investment and development strategies of the top 25 pharmaceutical companies according to 2015 worldwide prescription drug sales...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28641601/the-impact-of-traumatic-stress-on-pavlovian-biases
#5
O T Ousdal, Q J Huys, A M Milde, A R Craven, L Ersland, T Endestad, A Melinder, K Hugdahl, R J Dolan
BACKGROUND: Disturbances in Pavlovian valuation systems are reported to follow traumatic stress exposure. However, motivated decisions are also guided by instrumental mechanisms, but to date the effect of traumatic stress on these instrumental systems remain poorly investigated. Here, we examine whether a single episode of severe traumatic stress influences flexible instrumental decisions through an impact on a Pavlovian system. METHODS: Twenty-six survivors of the 2011 Norwegian terror attack and 30 matched control subjects performed an instrumental learning task in which Pavlovian and instrumental associations promoted congruent or conflicting responses...
June 23, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28633119/polymer-grafted-magnetic-halloysite-nanotube-for-controlled-and-sustained-release-of-cationic-drug
#6
Meriem Fizir, Pierre Dramou, Kai Zhang, Cheng Sun, Chuong Pham-Huy, Hua He
In this research, novel polymer grafted-magnetic halloysite nanotubes with norfloxacin loaded (NOR-MHNTs) and controlled-release, was achieved by surface-initiated precipitation polymerization. The magnetic halloysite nanotubes exhibited better adsorption of NOR (72.10mgg(-1)) compared with the pristine HNTs (30.80mgg(-1)). Various parameters influencing the drug adsorption of the MHNTs for NOR were studied. Polymer grafted NOR-MHNTs has been designed using flexible docking in computer simulation to choose optimal monomers...
April 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28622046/online-research-club-a-mentoring-program-for-undergraduate-students
#7
Alessandro Sgro, Mohamed Gomaa Kamel, Thanh Huan Vuong, Ali Mahmoud Ahmed, Tien Huy Nguyen
No abstract text is available yet for this article.
June 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28621837/pediatric-follicular-thyroid-carcinoma-indolent-cancer-with-low-prevalence-of-ras-mutations-and-absence-of-pax8-pparg-fusion-in-a-japanese-population
#8
Huy Gia Vuong, Tetsuo Kondo, Naoki Oishi, Tadao Nakazawa, Kunio Mochizuki, Akira Miyauchi, Mitsuyoshi Hirokawa, Ryohei Katoh
BACKGROUND: Pediatric follicular thyroid carcinomas are uncommon and their clinicopathological features and molecular profiles are still unknown. In this present study, we aimed to investigate the clinicopathological aspects of a large series of follicular thyroid carcinomas (FTCs) in pediatric patients and to analyse the point mutations in codons 12, 13 and 61 of NRAS, HRAS and KRAS genes and the rearrangements of PAX8-PPARG. METHODS: A total of 41 pediatric FTCs less than 21 years of age were enrolled in the present study...
June 16, 2017: Histopathology
https://www.readbyqxmd.com/read/28620302/adoption-of-biosimilar-infliximab-for-rheumatoid-arthritis-ankylosing-spondylitis-and-inflammatory-bowel-diseases-in-the-eu5-a-budget-impact-analysis-using-a-delphi-panel
#9
Tim A Kanters, Jelena Stevanovic, Isabelle Huys, Arnold G Vulto, Steven Simoens
Introduction: Introducing biosimilar infliximab for the treatment in rheumatology (rheumatoid arthritis and ankylosing spondylitis) and inflammatory bowel disease (Crohn's disease and ulcerative colitis) may reduce treatment costs associated with biologics. This study aimed to investigate the budget impact of adopting biosimilar infliximab in five European countries, considering that the budget impact includes the adoption of biosimilar infliximab and the availability of biologic alternatives such as vedolizumab, biosimilar etanercept, biosimilar rituximab, and other relevant factors...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28619054/hgpec-a-cytoscape-app-for-prediction-of-novel-disease-gene-and-disease-disease-associations-and-evidence-collection-based-on-a-random-walk-on-heterogeneous-network
#10
Duc-Hau Le, Van-Huy Pham
BACKGROUND: Finding gene-disease and disease-disease associations play important roles in the biomedical area and many prioritization methods have been proposed for this goal. Among them, approaches based on a heterogeneous network of genes and diseases are considered state-of-the-art ones, which achieve high prediction performance and can be used for diseases with/without known molecular basis. RESULTS: Here, we developed a Cytoscape app, namely HGPEC, based on a random walk with restart algorithm on a heterogeneous network of genes and diseases...
June 15, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28612760/effects-of-growth-and-aging-on-the-reference-values-of-pulmonary-nitric-oxide-dynamics-in-healthy-subjects
#11
Marieann Högman, Alexandra Thornadtsson, Per Liv, Thong Hua-Huy, Anh-Tuan Dinh-Xuan, Ellen Tufvesson, Holger Dressel, Christer Janson, Kirsi Koskela, Panu Oksa, Riitta Sauni, Jukka Uitti, Eeva Moilanen, Lauri Lehtimäki
The lung just like all other organs is affected by age. The lung matures by the age of 20 and age related changes starts around middle age, 40-50 years. Exhaled nitric oxide (F<sub></sub>E<sub></sub>NO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (C<sub>A</sub>NO), airway flux (J<sub>aw</sub>NO), airway diffusing capacity (D<sub>aw</sub>NO) and airway wall content (C<sub>aw</sub>NO), will also demonstrate this dependence...
June 14, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28610143/a-new-species-of-i-leptolalax-i-anura-megophryidae-from-northern-vietnam
#12
Jodi J L Rowley, Vinh Q Dau, Huy D Hoang, Duong T T LE, Timothy P Cutajar, Tao T Nguyen
We describe a new, medium-sized Leptolalax species from Vietnam. Leptolalax petrops sp. nov. is distinguished from its congeners by a combination of having a medium-sized body (23.6-27.6 mm in 21 adult males, 30.3-47.0 mm in 17 adult females), immaculate white chest and belly, no distinct black markings on the head, highly tuberculate skin texture, toes lacking webbing and with narrow lateral fringes, and a call consisting of an average of four notes and a dominant frequency of 5.6-6.4 kHz (at 24.5-25.3 °C)...
March 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28596601/ebbinghaus-figures-that-deceive-the-eye-do-not-necessarily-deceive-the-hand
#13
Hester Knol, Raoul Huys, Jean-Christophe Sarrazin, Andreas Spiegler, Viktor K Jirsa
In support of the visual stream dissociation hypothesis, which states that distinct visual streams serve vision-for-perception and vision-for-action, visual size illusions were reported over 20 years ago to 'deceive the eye but not the hand'. Ever since, inconclusive results and contradictory interpretations have accumulated. Therefore, we investigated the effects of the Ebbinghaus figure on repetitive aiming movements with distinct dynamics. Participants performed a Fitts' task in which Ebbinghaus figures served as targets...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581644/hepatitis-b-surface-antigen-loss-and-sustained-viral-suppression-in-asian-chronic-hepatitis-b-patients-a-community-based-real-world-study
#14
Robert J Wong, My T Nguyen, Huy N Trinh, Chuck Chan, Andrew Huynh, My Tops Ly, Huy A Nguyen, Khanh K Nguyen, Sharon Torres, Jenny Yang, Benny Liu, Ruel T Garcia, Taft Bhuket, Rachel Baden, Brian Levitt, Eduardo da Silveira, Robert G Gish
Community-based real-world outcomes on effectiveness of antiviral therapies for chronic hepatitis B virus (CHB) in Asians are limited. Whether hepatitis B surface antigen (HBsAg) loss correlates with undetectable virus and alanine aminotransferase (ALT) normalization on treatment or what predicts risk of seroreversion or detectable virus after stopping therapy is unclear. We aim to evaluate rates and predictors of HBsAg loss, seroconversion, ALT normalization and undetectable HBV DNA, including HBsAg seroreversion or re-emergence of HBV DNA among Asian CHB patients...
June 5, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28578114/inside-vietnam-s-largest-neurosurgery-department
#15
Constantine L Karras, Huy Minh Tran, David Dornbos, Phong Nguyen, Shahid M Nimjee, Daniel M Prevedello, Ciarán J Powers
Cho Ray Hospital is the premier tertiary care center in Ho Chi Minh City, Vietnam's most populous city. The neurosurgical department was founded in 1958 and is currently one of the busiest in the world. Last year the department was responsible for over 10,000 neurosurgical operations, excluding neuroendovascular cases. Most of the elective cases are craniotomies for complex lesions such as aneurysms, AMV's, skull base tumors, gliomas and meningiomas. While the neurosurgeons within the department are technically gifted, doing more with less predominates as the mantra at Cho Ray Hospital...
May 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28574188/hospital-acquired-anemia-due-to-diagnostic-and-therapy-related-blood-loss-in-inpatients-with-myasthenia-gravis-receiving-therapeutic-plasma-exchange
#16
Steven A Mann, Lance A Williams, Marisa B Marques, Huy P Pham
INTRODUCTION: Daily laboratory testing (DLT) is an important cause of iatrogenic anemia. Therapeutic plasma exchanges (TPE) represent another source of blood loss. This study investigated the contributions of DLT and TPE to changes in hemoglobin of inpatients with myasthenia gravis (MG) exacerbation. STUDY DESIGN AND METHODS: All admissions for MG that included TPE between 2008 and 2012 were identified. The DLT- and TPE-related blood losses per patient were estimated based on the number of laboratory tests and TPE procedures...
June 2, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28569602/factors-associated-with-risky-alcohol-consumption-among-male-street-laborers-in-urban-vietnam
#17
Lamprini Mylona, Nguyen Van Huy, Pham Nguyen Ha, Emilia Riggi, Gaetano Marrone
BACKGROUND: Alcohol consumption is of global concern. However, drinking patterns and associated factors remain under-investigated, especially among low socioeconomic groups such as street laborers. OBJECTIVE: Using the social cognitive model as a framework for the study we aimed to identify factors associated with risky alcohol consumption. METHODS: In a cross-sectional study using structured questionnaires, 450 male street laborers searching for casual works in Hanoi, Vietnam were interviewed...
June 1, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28569412/programmed-site-selective-direct-palladium-catalyzed-arylations-of-thieno-3-2-b-thiophene
#18
Tung Thanh Dang, Thi Minh Ha Vuong, Hien Nguyen, Didier Villemin, Thanh Tin Le, Hung Huy Nguyen
Mono-, di-, tri- and tetra-arylated thieno[3,2-b]thiophenes were synthesized by direct site-selective Pd-catalyzed C-H activation reactions with various aryl bromides in the presence of a phosphine-free Pd(OAc)2/KOAc catalyst system in DMAc. The arylation of 2-arylthieno[3,2-b]thiophen¬e took place at the C-3 position when the 2-aryl substituents bear electron-withdrawing groups, and at the C-5 position when they are bulky and possess electron-donating groups.
June 1, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28566444/prognostic-impact-of-vascular-invasion-in-differentiated-thyroid-carcinoma-a-systematic-review-and-meta-analysis
#19
Huy Gia Vuong, Tetsuo Kondo, Uyen N P Duong, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
The role of vascular invasion (VI) as a prognostic marker in thyroid cancer is continuously debated among investigators. In this systematic review and meta-analysis, we aimed to investigate the association of VI with tumor recurrence and patient mortality in differentiated thyroid cancers (DTCs). We searched five electronic databases and data of tumor persistence, loco-regional recurrence (LRR), distant recurrence (DR) and overall recurrence/persistence (RP) were extracted and pooled into odds ratios (OR) and corresponding 95% confidence intervals (CIs) using random effect model...
May 31, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28552635/the-in%C3%A2-vitro-and-in%C3%A2-vivo-protective-effects-of-tannin-derivatives-against-salmonella-enterica-serovar-typhimurium-infection
#20
Alisha Wehdnesday Bernardo Reyes, Tae Gyu Hong, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Wongi Min, Hu Jang Lee, Kang Seok Lee, Suk Kim
In this study, we investigated the protective effects of tannin-derived components, gallic acid (GA) and tannic acid (TA), in vitro and in vivo against Salmonella infection in mice. Both GA and TA showed antibacterial effects against Salmonella (S.) Typhimurium as well as inhibitory effects on the adherence, invasion, and intracellular growth of the pathogens in macrophages. Following a lethal dose of Salmonella infection in mice, reduced virulence in both GA- and TA-treated groups was observed based on reduced mortality rates...
May 24, 2017: Microbial Pathogenesis
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