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https://www.readbyqxmd.com/read/28435356/screening-and-production-of-manganese-peroxidase-from-fusarium-sp-on-residue-materials
#1
Nguyen Duc Huy, Nguyen Thi Thanh Tien, Le Thi Huyen, Hoang Tan Quang, Truong Quy Tung, Nguyen Ngoc Luong, Seung-Moon Park
In this study, we report the manganese peroxidase production ability from a Fusarium sp. strain using an inexpensive medium of agriculture residues of either rice straw or wood chips as carbon source. The highest manganese peroxidase activity on rice straw medium and on wood chips was 1.76 U/mL by day 9 and 1.91 U/mL by day 12, respectively.
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28434988/genotyping-of-helicobacter-pylori-shows-high-diversity-of-strains-circulating-in-central-vietnam
#2
Trung Nam Phan, Antonella Santona, Van Huy Tran, Thi Nhu Hoa Tran, Le Van An, Pietro Cappuccinelli, Salvatore Rubino, Bianca Paglietti
In Vietnam, the high prevalence of Helicobacter pylori infection represents a serious health problem. Virulence genes of H. pylori have been associated to increased risk of severe gastrointestinal diseases and the genetic background differs in geographical areas. We investigated cagA and vacA genotypes of H. pylori from dyspeptic patients from central Vietnam and the correlation with clinical outcomes; we also performed sequencing analysis of partial cagA gene. Overall, 84% of strains were cagA-positive, 75% were East-Asian type with a prevalence of vacAs1i1m1 and vacAs1i1m2 genotypes (66...
April 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28434915/x-ray-crystallography-and-electron-microscopy-of-cross-and-multi-module-nonribosomal-peptide-synthetase-proteins-reveal-a-flexible-architecture
#3
Michael J Tarry, Asfarul S Haque, Khanh Huy Bui, T Martin Schmeing
Nonribosomal peptide synthetases (NRPS) are macromolecular machines that produce peptides with diverse activities. Structural information exists for domains, didomains, and even modules, but little is known about higher-order organization. We performed a multi-technique study on constructs from the dimodular NRPS DhbF. We determined a crystal structure of a cross-module construct including the adenylation (A) and peptidyl carrier protein (PCP) domains from module 1 and the condensation domain from module 2, complexed with an adenosine-vinylsulfonamide inhibitor and an MbtH-like protein (MLP)...
April 17, 2017: Structure
https://www.readbyqxmd.com/read/28420990/managed-entry-agreements-for-oncology-drugs-lessons-from-the-european-experience-to-inform-the-future
#4
Kim Pauwels, Isabelle Huys, Sabine Vogler, Minne Casteels, Steven Simoens
Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regulatory framework and practice of MEA in Belgium, The Netherlands, Scotland, England and Wales, Sweden, Italy, Czech Republic and France. An overview of the content and typology of MEA applied for oncology drugs between 2008 and 2015 was generated based on publically available sources and contributions by national health authorities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28415555/yb-3-er-3-eu-3-codoped-yvo4-material-for-bioimaging-with-dual-mode-excitation
#5
Chu Thi Bich Thao, Bui The Huy, Mirkomil Sharipov, Jin-Ik Kim, Van-Duong Dao, Ja-Young Moon, Yong-Ill Lee
We propose an efficient bioimaging strategy using Yb(3+),Er(3+),Eu(3+)-triplet doped YVO4 nanoparticles which were synthesized with polymer as a template. The obtained particles possess nanoscale, uniform, and flexible excitation. The effect of Eu(3+) ions on the luminescence properties of YVO4:Yb(3+),Er(3+),Eu(3+) was investigated. The upconversion mechanism of the prepared material was also discussed. The structure and optical properties of the prepared material were characterized by using X-ray diffraction (XRD), Fourier-transform IR spectroscopy (FTIR), scanning electron microscopy (SEM), Transmission electron microscopy (TEM) upconversion and photoluminescence spectra...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28396694/synthesis-of-umbelliferone-derivatives-in-escherichia-coli-and-their-biological-activities
#6
Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim, Jae Kyung Sohng
BACKGROUND: Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human health. A uridine diphosphate glycosyltransferase YjiC from Bacillus licheniformis DSM 13, a cytochrome P450BM3 (CYP450 BM3) variant namely mutant 13 (M13) from Bacillus megaterium, and an O-methyltransferase from Streptomyces avermitilis (SaOMT2) were used for modifications of umbelliferone...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28392951/three-novel-mutations-in-the-nphs1-gene-in-vietnamese-patients-with-congenital-nephrotic-syndrome
#7
Thi Kim Lien Nguyen, Van Dem Pham, Thu Huong Nguyen, Trung Kien Pham, Thi Quynh Huong Nguyen, Huy Hoang Nguyen
Congenital nephrotic syndrome, a rare and severe disease, is inherited as an autosomal recessive trait. The disease manifests shortly after birth and occurs predominantly in families of Finnish origin but has now been observed in all countries and races. Mutations in the NPHS1 gene, which encodes nephrin, are the main causes of congenital nephrotic syndrome in patients. In this study, we report the first mutational analysis of the NPHS1 gene in three unrelated children from three different Vietnamese families...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28392422/the-effect-of-varying-the-peptide-linker-length-in-a-single-chain-variable-fragment-antibody-against-wogonin-glucuronide
#8
Madan Kumar Paudel, Seiichi Sakamoto, Le Van Huy, Hiroyuki Tanaka, Tomofumi Miyamoto, Satoshi Morimoto
Peptide linkers of three different lengths were constructed to join the variable regions of the heavy chain (VH) and the light chain (VL) in a single-chain variable fragment antibody (scFv) specific for wogonin glucuronide (Wgn) that has the structure VH-(GGGGS)n-VL (n=3, 5, or 7). The scFv antibodies, which were expressed in Escherichia coli, were derived from an anti-Wgn monoclonal antibody (315A). An indirect competitive enzyme-linked immunosorbent assay (icELISA) was used to evaluate their reactivity and sensitivity, which is also used for quantitative analysis of Wgn...
April 7, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28390240/defense-and-signalling-metabolites-of-the-crucifer-erucastrum-canariense-synchronized-abiotic-induction-of-phytoalexins-and-galacto-oxylipins
#9
M Soledade C Pedras, Q Huy To
Erucastrum canariense Webb & Berthel. (Brassicaceae) is a wild crucifer that grows in rocky soils, in salt and water stressed habitats, namely in the Canary Islands and similar environments. Abiotic stress induced by copper chloride triggered formation of a phytoalexin and galacto-oxylipins in E. canariense, whereas wounding induced galacto-oxylipins but not phytoalexins. Analysis of the metabolite profiles of leaves of E. canariense followed by isolation and structure determination afforded the phytoalexin erucalexin, the phytoanticipin indolyl-3-acetonitrile, the galacto-oxylipins arabidopsides A, C, and D, and the oxylipin 12-oxophytodienoic acid...
April 5, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28386896/antimicrobial-activity-of-aqueous-extracts-from-four-plants-on-bacterial-isolates-from-periodontitis-patients
#10
Leila Arbia, Nassima Chikhi-Chorfi, Ilhem Betatache, Chuong Pham-Huy, Selma Zenia, Nabil Mameri, Nadjib Drouiche, Hakim Lounici
Four aqueous extracts of different plant organs are the following: Artemisia herba-alba, Opuntia ficus-indica, Camellia sinensis and Phlomis crinita were evaluated against two bacterial strains: Porphyromonas gingivalis and Prevotella intermedia, which are implicated in periodontal diseases. By using a disc method, these plant extracts demonstrated powerful bacterial activity against these Gram-negative strains. The minimum inhibitory concentration values of the four plant extracts varied between 0.03 and 590...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28383049/suppressor-of-cytokine-signaling-2-negatively-regulates-nk-cell-differentiation-by-inhibiting-jak2-activity
#11
Won Sam Kim, Mi Jeong Kim, Dong Oh Kim, Jae-Eun Byun, Hangsak Huy, Hae Young Song, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Eun-Ji Choi, Haiyoung Jung, Inpyo Choi
Suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine responses. Although recent reports have shown regulatory roles for SOCS proteins in innate and adaptive immunity, their roles in natural killer (NK) cell development are largely unknown. Here, we show that SOCS2 is involved in NK cell development. SOCS2(-/-) mice showed a high frequency of NK cells in the bone marrow and spleen. Knockdown of SOCS2 was associated with enhanced differentiation of NK cells in vitro, and the transplantation of hematopoietic stem cells (HSCs) into congenic mice resulted in enhanced differentiation in SOCS2(-/-) HSCs...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28382932/association-of-glucose-6-phosphate-dehydrogenase-deficiency-and-malaria-a-systematic-review-and-meta-analysis
#12
Evaristus Chibunna Mbanefo, Ali Mahmoud Ahmed, Afaf Titouna, Ahmed Elmaraezy, Nguyen Thi Huyen Trang, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Bui The Hung, Mai Van Hieu, Nguyen Ky Anh, Nguyen Tien Huy, Kenji Hirayama
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency overlaps with malaria endemicity although it predisposes carriers to hemolysis. This fact supports the protection hypothesis against malaria. The aim of this systematic review is to assess the presence and the extent of protective association between G6PD deficiency and malaria. Thirteen databases were searched for papers reporting any G6PD alteration in malaria patients. Twenty-eight of the included 30 studies were eligible for the meta-analysis. Results showed absence of negative association between G6PD deficiency and uncomplicated falciparum malaria (odds ratio (OR), 0...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376260/cdc42-regulates-branching-in-angiogenic-sprouting-in-vitro
#13
Duc-Huy T Nguyen, Lin Gao, Alec Wong, Christopher S Chen
OBJECTIVES: The morphogenetic events that occur during angiogenic sprouting involve several members of the Rho family of GTPases, including Cdc42. However, the precise roles of Cdc42 in angiogenic sprouting have been difficult to elucidate owing to the lack of models to study these events in vitro. Here, we aim to identify the roles of Cdc42 in branching morphogenesis in angiogenesis. METHODS: Using a 3D biomimetic model of angiogenesis in vitro, where endothelial cells were seeded inside a cylindrical channel within collagen gel and sprouted from the channel in response to a defined biochemical gradient of angiogenic factors, we inhibited Cdc42 activity with a small molecule inhibitor ML141 and examined the effects of Cdc42 on the morphogenetic processes of angiogenic sprouting...
April 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28370432/antigenic-diversity-of-h5-highly-pathogenic-avian-influenza-viruses-of-clade-2-3-4-4-isolated-in-asia
#14
Ayako Ohkawara, Masatoshi Okamatsu, Makoto Ozawa, Duc-Huy Chu, Lam Thanh Nguyen, Takahiro Hiono, Keita Matsuno, Hiroshi Kida, Yoshihiro Sakoda
H5 highly pathogenic avian influenza viruses (HPAIVs) have spread in both poultry and wild birds since the late 2003. The continued circulation of HPAIVs in poultry in several regions of the world has led to antigenic drift. In this study, we analyzed the antigenic properties of H5 HPAIVs isolated in Asia using four neutralizing monoclonal antibodies (MAbs) recognizing the hemagglutinin, which were established using A/chicken/Kumamoto/1-7/2014 (H5N8), belonging to clade 2.3.4.4 and also using polyclonal antibodies...
March 30, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28363873/production-of-recombinant-human-acid-%C3%AE-glucosidase-with-high-mannose-glycans-in-gnt1-rice-for-the-treatment-of-pompe-disease
#15
Jae-Wan Jung, Nguyen-Xuan Huy, Hyo-Boon Kim, Nan-Sun Kim, Do Van Giap, Moon-Sik Yang
Lysosomal storage diseases are a group of inherited metabolic disorders. Patients are treated with enzyme replacement therapy (ERT), in which the replacement enzymes are required to carry terminal mannose or mannose 6-phosphate residues to allow efficient uptake into target cells and tissues. N-acetylglucosaminyltransferase-I (GnTI) mediates N-glycosylation in the cis cisternae of the Golgi apparatus by adding N-acetylglucosamine to the exposed terminal mannose residue of core N-glycan structures for further processing...
March 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28360211/quantitation-of-cancer-treatment-response-by-fdg-pet-ct-multi-center-assessment-of-measurement-variability
#16
Joo Hyun O, Heather A Jacene, Brandon Luber, Hao Wang, Jeff Leal, Minh-Huy Huynh, Richard L Wahl
To assess the inter-observer variability of quantitative F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters used in assessments of treatment response across multiple sites and readers. Methods: Paired pre- and post-treatment FDG PET/CT images of 30 oncologic patients were distributed to 22 readers across 15 United States and international sites. One reader was aware of the full medical history (readreference), while the 21 other readers were unaware. The readers selected the single "hottest tumor" from each study, and made standard uptake value (SUV) measurements from this target lesion and the liver...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28356764/study-of-nasal-exhaled-nitric-oxide-levels-in-diagnosis-of-allergic-rhinitis-in-subjects-with-and-without-asthma
#17
Sy Duong-Quy, Thuc Vu-Minh, Thong Hua-Huy, Tram Tang-Thi-Thao, Khiet Le-Quang, Dinh Tran-Thanh, Nhu Doan-Thi-Quynh, Nhat-Nam Le-Dong, Timothy J Craig, Anh-Tuan Dinh-Xuan
BACKGROUND: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. OBJECTIVE: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and AR-asthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28356479/dynamical-signatures-of-isometric-force-control-as-a-function-of-age-expertise-and-task-constraints
#18
Solveig Vieluf, Rita Sleimen-Malkoun, Claudia Voelcker-Rehage, Viktor Jirsa, Eva-Maria Reuter, Ben Godde, Jean-Jacques Temprado, Raoul Huys
From the conceptual and methodological framework of the dynamical systems approach, force control results from complex interactions of various subsystems yielding observable behavioral fluctuations, which comprise both deterministic (predictable) and stochastic (noise-like) dynamical components. Here, we investigated these components contributing to the observed variability in force control in groups of participants differing in age and expertise level. To this aim, young (18 - 25 years) as well as late middle-aged (55 -65 years) novices and experts (precision mechanics) performed a force maintenance and a force modulation task...
March 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28356182/the-efficacy-of-low-level-continuous-positive-airway-pressure-for-the-treatment-of-snoring
#19
Michelle A Guzman, Francis P Sgambati, Huy Pho, Rafael S Arias, Erin M Hawks, Erica M Wolfe, Tamás Ötvös, Russell Rosenberg, Riad Dakheel, Hartmut Schneider, Jason P Kirkness, Philip L Smith, Alan R Schwartz
STUDY OBJECTIVES: To assess effects of low-level continuous positive airway pressure (CPAP) on snoring in habitual snorers without obstructive sleep apnea (OSA). METHODS: A multicenter prospective in-laboratory reversal crossover intervention trial was conducted between September 2013 and August 2014. Habitual snorers were included if they snored (inspiratory sound pressure level ≥ 40 dBA) for ≥ 30% all sleep breaths on a baseline sleep study (Night 1), and if significant OSA and daytime somnolence were absent...
February 19, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28350827/time-spent-by-belgian-hospital-pharmacists-on-supply-disruptions-and-drug-shortages-an-exploratory-study
#20
Elfi De Weerdt, Thomas De Rijdt, Steven Simoens, Minne Casteels, Isabelle Huys
INTRODUCTION: Supply problems of drugs are an increasing and worldwide problem, also in Belgium. Hospital pharmacists try to manage drug supply problems to minimize the impact on patient care. This study aims to quantify in a detailed manner how much time employees of 17 Belgian hospital pharmacies spend on drug supply problems. METHODS: During six months, employees of Belgian hospital pharmacies filled in the daily time spent on drug supply problems using a template containing all steps which can be executed to manage drug supply problems...
2017: PloS One
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