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https://www.readbyqxmd.com/read/28729702/structure-of-general-population-antibody-titer-distributions-to-influenza-a-virus
#1
Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F Boni
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717706/cancer-pain-management-insights-and-reality-in-southeast-asia-expert-perspectives-from-six-countries
#2
Francis O Javier, Cosphiadi Irawan, Marzida Binti Mansor, Wimonrat Sriraj, Kian Hian Tan, Dang Huy Quoc Thinh
This expert opinion report examines the current realities of the cancer pain management landscape and the various factors that hinder optimal pain control in six countries in Southeast Asia, describes ongoing efforts to advance patient care, and discusses approaches for improving cancer pain management. Information was gathered from leading experts in the field of cancer pain management in each country through an initial meeting and subsequent e-mail discussions. Overall, there are vast disparities in cancer pain management practices and access to opioids in the Southeast Asian countries...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28704461/assessing-the-performance-of-remotely-sensed-flooding-indicators-and-their-potential-contribution-to-early-warning-for-leptospirosis-in-cambodia
#3
Julia Ledien, Sopheak Sorn, Sopheak Hem, Rekol Huy, Philippe Buchy, Arnaud Tarantola, Julien Cappelle
Remote sensing can contribute to early warning for diseases with environmental drivers, such as flooding for leptospirosis. In this study we assessed whether and which remotely-sensed flooding indicator could be used in Cambodia to study any disease for which flooding has already been identified as an important driver, using leptospirosis as a case study. The performance of six potential flooding indicators was assessed by ground truthing. The Modified Normalized Difference Water Index (MNDWI) was used to estimate the Risk Ratio (RR) of being infected by leptospirosis when exposed to floods it detected, in particular during the rainy season...
2017: PloS One
https://www.readbyqxmd.com/read/28701266/community-acquired-bloodstream-infections-caused-by-acinetobacter-baumannii-a%C3%A2-matched-case-control-study
#4
Chung-Ting Chen, Yung-Chih Wang, Shu-Chen Kuo, Fang-Huy Shih, Te-Li Chen, Chorng-Kuang How, Ya-Sung Yang, Yi-Tzu Lee
BACKGROUND: Acinetobacter baumannii is an important nosocomial pathogen worldwide. Its role in community-acquired infection remains controversial and has rarely been reported. METHODS: Patients with monobacterial bloodstream infections caused by genomic species identified A. baumannii, admitted to Taipei Veterans General Hospital between 1999 and 2010, were selected as cases. Controls were defined as patients acquiring infection in a healthcare setting and were matched for age and sex...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28697451/reduced-efficacy-of-albendazole-against-ascaris-lumbricoides-in-rwandan-schoolchildren
#5
Jürgen Krücken, Kira Fraundorfer, Jean Claude Mugisha, Sabrina Ramünke, Kevin C Sifft, Dominik Geus, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Caritas Mukampunga, Claude Bayingana, Toni Aebischer, Janina Demeler, Jean Bosco Gahutu, Frank P Mockenhaupt, Georg von Samson-Himmelstjerna
Control of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resistance (AR) is a common problem in nematodes of veterinary importance but for human STHs, information on drug efficacy is limited and routine monitoring is rarely implemented. Herein, the efficacy of single dose albendazole (400 mg) was evaluated in 12 schools in the Huye district of Rwanda where Ascaris is the predominant STH. Ascaris eggs were detected by wet mount microscopy and the Mini-FLOTAC method to assess cure rate (CR) and faecal egg count reduction (FECR)...
June 23, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28696662/edge-delamination-of-monolayer-transition-metal-dichalcogenides
#6
Thuc Hue Ly, Seok Joon Yun, Quoc Huy Thi, Jiong Zhao
Delamination of thin films from the supportive substrates is a critical issue within the thin film industry. The emergent two-dimensional, atomic layered materials, including transition metal dichalcogenides, are highly flexible; thus buckles and wrinkles can be easily generated and play vital roles in the corresponding physical properties. Here we introduce one kind of patterned buckling behavior caused by the delamination from a substrate initiated at the edges of the chemical vapor deposition synthesized monolayer transition metal dichalcogenides, led by thermal expansion mismatch...
July 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28694451/polymorphic-regulation-of-mitochondrial-fission-and-fusion-modifies-phenotypes-of-microglia-in-neuroinflammation
#7
Mitsuhiko Katoh, Bao Wu, Huy Bang Nguyen, Truc Quynh Thai, Ryo Yamasaki, Haiyan Lu, Anna M Rietsch, Musab M Zorlu, Youichi Shinozaki, Yurika Saitoh, Sei Saitoh, Takashi Sakoh, Kazuhiro Ikenaka, Schuichi Koizumi, Richard M Ransohoff, Nobuhiko Ohno
Microglia are the resident macrophages of the central nervous system and play complex roles in the milieu of diseases including the primary diseases of myelin. Although mitochondria are critical for cellular functions and survival in the nervous system, alterations in and the roles of mitochondrial dynamics and associated signaling in microglia are still poorly understood. In the present study, by combining immunohistochemistry and 3D ultrastructural analyses, we show that mitochondrial fission/fusion in reactive microglia is differentially regulated from that in monocyte-derived macrophages and the ramified microglia of normal white matter in myelin disease models...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693306/tannic-acid-mediated-immune-activation-attenuates-brucella-abortus-infection-in-mice
#8
Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Wongi Min, Hu Jang Lee, Hong Hee Chang, Suk Kim
Brucellosis is an emerging infectious disease affecting humans and animals. In this study, we investigated the in vitro and in vivo effects of tannic acid (TA) against Brucella (B.) abortus infection. Reduced F-actin polymerization and MAPKs (ERK 1/2 and p38α) phosphorylation were observed in TA-treated cells as compared with control cells after infection. The mice were infected via intraperitoneal route and were orally given with TA or PBS for 14 days. The weights of the spleens from TA-treated and control mice were not different, however the splenic proliferation of B...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28691821/in-situ-electron-driven-carbon-nanopillar-fullerene-transformation-through-cr-atom-mediation
#9
Liang Zhao, Huy Quang Ta, Arezoo Dianat, Akash Soni, Artem Fediai, Wan-Jian Yin, Thomas Gemming, Barbara Trzebicka, Gianaurelio Cuniberti, Zhongfan Liu, Alicja Bachmatiuk, Mark H Rummeli
The promise of sp2 nano-materials remains immense and ways to strategically combine and manipulate these nano-structures will further enhance their potential as well as advance nanotechnology as a whole. The scale of these structures requires precision at the atomic scale. In this sense electron microscopes are attractive as they offer both atomic imaging and a means to structurally modify structures. Here we show how Cr atoms can be used as physical linkers to connect carbon nanotubes and fullerenes to graphene...
July 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28689412/bexarotene-does-not-clear-amyloid-beta-plaques-but-delays-fibril-growth-molecular-mechanisms
#10
Pham Dinh Quoc Huy, Nguyen Quoc Thai, Zuzana Bednarikova, Le Huu Phuc, Huynh Quang Linh, Zuzana Gazova, Mai Suan Li
In 2012, it was reported that anticancer drug bexarotene reduced amyloid plaque and improved mental functioning in a small sample of mice engineered to exhibit Alzheimer's like symptoms. It has been suggested that bexarotene stimulates expression of apolipoprotein E (ApoE) leading to intracellular clearance of amyloid beta (Aβ). However, the effect of bexarotene on clearance of plaques has not been seen in some mouse models. Two interesting questions include whether bexarotene can destroy Aβ fibrils via direct interaction with them and how this compound impacts the lag phase in the fibril growth process...
July 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28689151/remobilization-of-polycyclic-aromatic-hydrocarbons-and-organic-matter-in-seawater-during-sediment-resuspension-experiments-from-a-polluted-coastal-environment-insights-from-toulon-bay-france
#11
Catherine Guigue, Marc Tedetti, Duc Huy Dang, Jean-Ulrich Mullot, Cédric Garnier, Madeleine Goutx
Polycyclic aromatic hydrocarbons (PAHs) and organic matter contents were measured in seawater during resuspension experiments using sediments collected from Toulon Bay (Northwestern Mediterranean Sea, France). The studied sediments were very highly contaminated in PAHs, especially in 4-ring compounds emitted from combustion processes. The sediments used for resuspension experiments were collected at 0-2 cm (diagenetically new organic matter, OM) and 30-32 cm depths (diagenetically transformed OM). They were both mostly composed of fine particles (<63 μm), enriched in organic carbon (8...
July 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28687202/aunp-ctg-based-probing-system-targeting-cag-repeat-dna-and-rna-sequences
#12
Binh Huy Le, Han Na Joo, Do Won Hwang, Kyu Wan Kim, Young Jun Seo
We have developed a AuNP-CTG based probing system that is applicable to the detection of many units of CAG repeat sequences which was synthesized by a rolling circle amplification (RCA) system with changes in fluorescence. We also demonstrate that our AuNP-CTG based probing system could transfect without using transfection reagent and detect target CAG repeat sequences in HeLa cells with dramatic changes in fluorescence. This AuNP-CTG based probing system could also be used, in conjunction with the CAG repeat RCA system, to detect target DNA...
June 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28680002/chromophobe-renal-cell-carcinoma-like-thyroid-carcinoma-a-novel-clinicopathologic-entity-possibly-associated-with-tuberous-sclerosis-complex
#13
Mitsuyoshi Hirokawa, Akira Miyauchi, Minoru Kihara, Takumi Kudo, Yuko Hashimoto, Shinichi Suzuki, Tsutomu Daa, Huy Gia Vuong, Norisato Mitsutake
We report three cases of chromophobe renal cell carcinoma-like thyroid carcinoma as a novel clinicopathologic entity possibly associated with tuberous sclerosis complex. A 15-year-old female, a 19-year-old male, and a 21-year-old male presented with primary thyroid carcinoma. Two of the patients had associated tuberous sclerosis complex. Macroscopically, the carcinomas showed invasive growth. Histologically, the carcinoma cells showed a trabecular pattern with thin vascular stroma, and were characterized by abundant eosinophilic cytoplasm with perinuclear clearing, a prominent cell border, a wrinkled nuclear membrane, and binucleation, which are all features of chromophobe renal cell carcinoma...
July 6, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28674955/herbicide-zn-al-layered-double-hydroxide-hybrid-composite-synthesis-and-slow-controlled-release-properties
#14
Nguyen Thi Kim Phuong, Ho Nguyen Nhat Ha, Nguyen Thi Phuong Dieu, Bui The Huy
The herbicide glyphosate (GLY) or 2,4-dichlorophenoxyacetic acids (2,4D) was intercalated in the interlayer region of a Zn-Al-layered double hydroxide (LDH) to obtain LDH-GLY or the LDH-2,4D hybrid composite because of its controlled release. Compared to the physically mixed herbicides, the LDH-herbicide hybrid composite displayed slow-release properties in decarbonated distilled water. The release rate of herbicides was found to be dependent on the carbonate and chloride anion concentrations in solution. The time at which 50% of the herbicides were released from the hybrid composite into solution, t 50, ranged from 6...
July 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28673442/when-habits-are-dangerous-alcohol-expectancies-and-habitual-decision-making-predict-relapse-in-alcohol-dependence
#15
Miriam Sebold, Stephan Nebe, Maria Garbusow, Matthias Guggenmos, Daniel J Schad, Anne Beck, Soeren Kuitunen-Paul, Christian Sommer, Robin Frank, Peter Neu, Ulrich S Zimmermann, Michael A Rapp, Michael N Smolka, Quentin J M Huys, Florian Schlagenhauf, Andreas Heinz
BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients...
May 22, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28671035/molecular-characterization-of-%C3%AE-thalassemia-mutations-in-central-vietnam
#16
Maria G Doro, Giuseppina Casu, Laura Frogheri, Ivana Persico, Le Phan Minh Triet, Phan Thi Thuy Hoa, Nguyen Huy Hoang, Monica Pirastru, Paolo Mereu, Francesco Cucca, Bruno Masala
The molecular basis of β-thalassemia (β-thal) mutations in North and in South Vietnam have been described during the past 15 years, whereas limited data were available concerning the central area of the country. In this study, we describe the molecular characterization and frequency of β-globin gene mutations in the Thua Thien Hue Province of Central Vietnam as the result of a first survey conducted in 22 transfusion-dependent patients, and four unrelated heterozygotes. Nine different known mutations were identified (seven of the β(0) and two of the β(+) type) in a total of 48 chromosomes...
March 2017: Hemoglobin
https://www.readbyqxmd.com/read/28667383/comparison-of-fixed-bearing-and-mobile-bearing-total-knee-arthroplasty-after-high-tibial-osteotomy
#17
Philippe Hernigou, Maxime Huys, Jacques Pariat, François Roubineau, Charles Henri Flouzat Lachaniette, Arnaud Dubory
PURPOSE: There is no information comparing the results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in the same patients previously treated by high tibial osteotomy. The purpose was therefore to compare fixed-bearing and mobile-bearing total knee replacements in patients treated with previous high tibial osteotomy. METHODS: We compared the results of 57 patients with osteoarthritis who had received a fixed-bearing prosthesis after high tibial osteotomy with the results of 41 matched patients who had received a rotating platform after high tibial osteotomy...
June 30, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28666074/prognostic-implication-of-braf-and-tert-promoter-mutation-combination-in-papillary-thyroid-carcinoma-a-meta-analysis
#18
REVIEW
Huy Gia Vuong, Ahmed M A Altibi, Uyen N P Duong, Lewis Hassell
INTRODUCTION: he use of molecular markers, especially BRAF and TERT promoter mutations, for risk stratification in papillary thyroid carcinoma (PTC) is subject to continuing debate. In this study, we aimed to investigate the clinicopathological implication of each genotype when combining BRAF and TERT promoter mutations in PTCs. METHODS: We searched four electronic databases including PubMed, Scopus, Web of Science and Virtual Health Library for relevant studies...
June 30, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28665957/post-dengue-acute-disseminated-encephalomyelitis-a-case-report-and-meta-analysis
#19
Mohamed Gomaa Kamel, Nguyen Tran Nam, Nguyen Huu Bao Han, Abd-Elaziz El-Shabouny, Abd-ElRahman Mohamed Makram, Fatma Abd-Elshahed Abd-Elhay, Tran Ngoc Dang, Nguyen Le Trung Hieu, Vu Thi Que Huong, Trinh Huu Tung, Kenji Hirayama, Nguyen Tien Huy
BACKGROUND: Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case. METHODOLOGY/PRINCIPAL FINDINGS: We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher's exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28660556/the-effect-of-endothelin-receptor-antagonists-in-patients-with-eisenmenger-syndrome-a-systematic-review
#20
REVIEW
Abdelrahman Elshafay, Duy Hieu Truong, Mohamed M AboElnas, Hossam Idrees, Hatem G Metwali, Nguyen Lam Vuong, Omar Ahmed Saad, Kenji Hirayama, Nguyen Tien Huy
INTRODUCTION: The efficacy of endothelin receptor antagonists (ERAs) in the management of Eisenmenger syndrome (ES) remains controversial. The aim of this study is to systemically review the safety and effects of ERAs in improving the quality of life and basic cardiac functions of these patients. METHODS: Twelve databases were searched, including PubMed, Web of Science, Scopus, Virtual Health Library, World Health Organization (WHO) Global Health Library, Google Scholar, POPLINE, Systems for Information of Grey Literature in Europe, New York Academy of Medicine, ClinicalTrials...
June 28, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
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