keyword
MENU ▼
Read by QxMD icon Read
search

Huys

keyword
https://www.readbyqxmd.com/read/28214557/quadruple-first-line-drug-resistance-in-mycobacterium-tuberculosis-in-vietnam-what-can-we-learn-from-genes
#1
Huy Quang Nguyen, Nhung Viet Nguyen, Lucie Contamin, Thanh Hoa Thi Tran, Thuong Thi Vu, Hung Van Nguyen, Ngoc Lan Thi Nguyen, Son Thai Nguyen, Anh Duc Dang, Anne-Laure Bañuls, Van Anh Thi Nguyen
In Vietnam, a country with high tuberculosis (137/100.000 population) and multidrug-resistant (MDR)-TB burdens (7.8/100.000 population), little is known about the molecular signatures of drug resistance in general and more particularly of second line drug (SLD) resistance. This study is specifically focused on Mycobacterium tuberculosis isolates resistant to four first-line drugs (FLDs) that make TB much more difficult to treat. The aim is to determine the proportion of SLD resistance in these quadruple drug resistant isolates and the genetic determinants linked to drug resistance to better understand the genetic processes leading to quadruple and extremely drug resistance (XDR)...
February 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28212641/local-constraints-to-access-appropriate-malaria-treatment-in-the-context-of-parasite-resistance-in-cambodia-a-qualitative-study
#2
Jesse Verschuere, Tom Decroo, Dara Lim, Jean-Marie Kindermans, Chea Nguon, Rekol Huy, Yasmine Alkourdi, Koen Peeters Grietens, Charlotte Gryseels
BACKGROUND: Despite emerging drug resistance in Cambodia, artemisinin-based combination therapy (ACT) is still the most efficacious therapy. ACT is available free of charge in the Cambodian public sector and at a subsidized rate in the private sector. However, un- and mistreated cases in combination with population movements may lead to the further spread of resistant parasites, stressing the importance of understanding how the perceived aetiology of malaria and associated health-seeking behaviour may delay access to appropriate treatment...
February 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28210393/has-vitamin-d-had-its-time-in-the-sun-for-melanoma
#3
Christopher J Huerter, Adam Vaudreuil, Devendra K Agrawal, Austin Huy Nguyen
Growing evidence suggests a pivotal role for vitamin D in cancers, particularly melanoma. The broad immunologic effects of vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for vitamin D supplementation in cancer prevention and/or adjuvant therapy. In this commentary, the authors highlight studies of vitamin D in melanoma with clinical implications and call for large clinical trials to definitively determine the role of supplementation in patients to prevent and help treat melanoma...
December 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28209180/are-products-with-an-orphan-designation-for-oncology-indications-different-from-products-for-other-rare-indications-a-retrospective-analysis-of-european-orphan-designations-granted-between-2002-2012
#4
Kim Pauwels, Isabelle Huys, Minne Casteels, Kristina Larsson, Caroline Voltz, Karri Penttila, Thomas Morel, Steven Simoens
BACKGROUND: Orphan designated medicinal products benefit from regulatory and economic incentives for orphan drug development. Approximately 40% of orphan designations target rare neoplastic disorders, referring to rare cancers. In order to provide more insights in drugs for rare neoplastic disorders that are under development and to better understand the role of orphan designation in the development of oncology drugs, this study investigates the characteristics of the product, the indication and the applicants as well as the stage of development of products with an orphan designation for rare neoplastic disorders and compares them with products with an orphan designation for other rare indications...
February 16, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28196113/chasm-in-primary-care-provision-in-a-universal-health-system-findings-from-a-nationally-representative-survey-of-health-facilities-in-malaysia
#5
Huy Ming Lim, Sheamini Sivasampu, Ee Ming Khoo, Kamaliah Mohamad Noh
BACKGROUND: Malaysia has achieved universal health coverage since 1980s through the expansion of direct public provision, particularly in rural areas. However, no systematic examination of the rural-urban distribution of primary care services and resources has been conducted to date for policy impact evaluation. METHODS: We conducted a national cross-sectional survey of 316 public and 597 private primary care clinics, selected through proportionate stratified random sampling, from June 2011 through February 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28192916/combating-enhanced-intracellular-survival-eis-mediated-kanamycin-resistance-of-mycobacterium-tuberculosis-by-novel-pyrrolo-1-5-a-pyrazine-based-eis-inhibitors
#6
Atefeh Garzan, Melisa J Willby, Huy X Ngo, Chathurada S Gajadeera, Keith D Green, Selina Y L Holbrook, Caixia Hou, James E Posey, Oleg V Tsodikov, Sylvie Garneau-Tsodikova
Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]pyrazine-based analogues as highly potent inhibitors of the Mycobacterium tuberculosis (Mtb) acetyltransferase enhanced intracellular survival (Eis), whose up-regulation causes clinically observed resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN)...
February 17, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28184201/long-term-high-fat-diet-treatment-an-appropriate-approach-to-study-the-sex-specificity-of-the-autonomic-and-cardiovascular-responses-to-obesity-in-mice
#7
Thiago Bruder-Nascimento, Obioma J Ekeledo, Ruchi Anderson, Huy B Le, Eric J Belin de Chantemèle
Obesity-related cardiovascular disease (CVD) involves increased sympathetic activity in men and male animals. Although women exhibit increased visceral fat, metabolic disorders, inflammation and CVD with obesity, whether body weight gain affects autonomic control of cardiovascular function in females remain unknown. Due to the lack of adequate model to mimic the human pathology, this study aimed to develop a murine model, which would allow studying the sex-specificity of the response of the autonomic nervous system to obesity and identifying the origin of potential sex-differences...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28183787/prognostic-significance-of-diffuse-sclerosing-variant-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis
#8
Huy Gia Vuong, Tetsuo Kondo, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
OBJECTIVE: Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma (PTC). The biological behaviors and prognostic outcomes of this variant, however, are still controversial. The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison with classical PTCs (cPTCs). METHODS: An electronic search was performed in five libraries: PubMed, Scopus, ISI, World Health Organization Global Health Library (WHO GHL) and Virtual Health Library (VHL) in June 2016...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28183502/a-27-year-old-man-with-acute-severe-low-back-pain-and-bilateral-leg-swelling-that-prompted-renting-a-wheelchair-for-mobility
#9
John G Williams, Huy Phan, Helena R Winston, Randolph V Fugit, Bridget Graney, Brant Jamroz, Benjamin English, Edward D Chan
A 27-year-old man with OSA, posttraumatic stress disorder, and chronic mechanical back pain presented with a 3-day history of acute atraumatic worsening of his low back pain as well as right groin numbness that was exacerbated by walking. He also complained of bilateral leg "heaviness," pain, and swelling, all becoming so severe that he rented a wheelchair for mobility.
February 2017: Chest
https://www.readbyqxmd.com/read/28166749/antidiabetic-effects-of-brucea-javanica-seeds-in-type-2-diabetic-rats
#10
Abdulwali Ablat, Mohammed Farouq Halabi, Jamaludin Mohamad, Muhammad Hafiz Husna Hasnan, Hazrina Hazni, Ser-Huy Teh, Jamil A Shilpi, Zulqarnain Mohamed, Khalijah Awang
BACKGROUND: Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate with their pharmacological activities. METHODS: A hydroethanolic extract of B...
February 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28166382/saccharopolyspora-species-laboratory-maintenance-and-enhanced-production-of-secondary-metabolites
#11
Dipesh Dhakal, Anaya Raj Pokhrel, Amit Kumar Jha, Nguyen Huy Thuan, Jae Kyung Sohng
Saccharopolyspora spp. are aerobic, Gram-positive, non-acid-fast, and non-motile actinomycetes. Various species of the genus Saccharopolyspora have been reported with an ability to produce various bioactive compounds for pharmaceutical and agricultural uses. This unit includes general protocols for the laboratory maintenance of Saccharopolyspora species, including growth in liquid medium, growth on solid agar, long-term storage, and generation of a higher producer strain by mutagenesis. Saccharopolyspora spinosa ATCC 49460 is used as a prototype for explaining the considerations for efficient laboratory maintenance of Saccharopolyspora spp...
February 6, 2017: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/28161569/the-spread-of-artemisinin-resistant-plasmodium-falciparum-in-the-greater-mekong-subregion-a-molecular-epidemiology-observational-study
#12
Mallika Imwong, Kanokon Suwannasin, Chanon Kunasol, Kreepol Sutawong, Mayfong Mayxay, Huy Rekol, Frank M Smithuis, Tin Maung Hlaing, Kyaw M Tun, Rob W van der Pluijm, Rupam Tripura, Olivo Miotto, Didier Menard, Mehul Dhorda, Nicholas P J Day, Nicholas J White, Arjen M Dondorp
BACKGROUND: Evidence suggests that the PfKelch13 mutations that confer artemisinin resistance in falciparum malaria have multiple independent origins across the Greater Mekong subregion, which has motivated a regional malaria elimination agenda. We aimed to use molecular genotyping to assess antimalarial drug resistance selection and spread in the Greater Mekong subregion. METHODS: In this observational study, we tested Plasmodium falciparum isolates from Myanmar, northeastern Thailand, southern Laos, and western Cambodia for PfKelch13 mutations and for Pfplasmepsin2 gene amplification (indicating piperaquine resistance)...
February 1, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28152038/exome-sequencing-covers-98-of-mutations-identified-on-targeted-next-generation-sequencing-panels
#13
Holly LaDuca, Kelly D Farwell, Huy Vuong, Hsiao-Mei Lu, Wenbo Mu, Layla Shahmirzadi, Sha Tang, Jefferey Chen, Shruti Bhide, Elizabeth C Chao
BACKGROUND: With the expanded availability of next generation sequencing (NGS)-based clinical genetic tests, clinicians seeking to test patients with Mendelian diseases must weigh the superior coverage of targeted gene panels with the greater number of genes included in whole exome sequencing (WES) when considering their first-tier testing approach. Here, we use an in silico analysis to predict the analytic sensitivity of WES using pathogenic variants identified on targeted NGS panels as a reference...
2017: PloS One
https://www.readbyqxmd.com/read/28150987/who-r-u-on-the-in-accuracy-of-incumbent-based-estimates-of-range-restriction-in-criterion-related-and-differential-validity-research
#14
Philip L Roth, Huy Le, In-Sue Oh, Chad H Van Iddekinge, Steven B Robbins
Correcting validity estimates for selection procedures for range restriction typically involves comparing variance in predictor scores between all job applicants and applicants who were selected. However, some research on criterion-related and differential validity of cognitive ability tests has relied on range restriction corrections based on data from job incumbents. Unfortunately, there remains ambiguity concerning the accuracy of this incumbent-based approach vis-à-vis the applicant-based approach. To address this issue, we conducted several Monte Carlo simulations, as well as an analysis of college admissions data...
February 2, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28144866/characteristics-of-ammonia-gas-and-fine-particulate-ammonium-from-two-distinct-urban-areas-osaka-japan-and-ho-chi-minh-city-vietnam
#15
Duong Huu Huy, Le Tu Thanh, To Thi Hien, Kazushi Noro, Norimichi Takenaka
Continuous and simultaneous measurements of ammonia gas (NH3) and fine particulate ammonium (PM2.5NH4(+)) were performed in two distinct urban areas: Osaka, Japan, and Ho Chi Minh City (HCMC), Vietnam. Measurements were performed using a new online instrument. Two measurement periods were conducted during February 11-March 12, 2015 (cold period), and July 1-September 14, 2015 (warm period), at the urban site in Osaka, while 17 days of measurements, from May 21 to June 8, 2015, were conducted at the urban site in HCMC...
January 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28141505/sphingobacterium-cellulitidis-sp-nov-isolated-from-clinical-and-environmental-sources
#16
Geert Huys, Prashant Purohit, Chuan Hao Tan, Cindy Snauwaert, Paul De Vos, Huda Al Saffar, Ina'am Al Obaid, M John Albert, Hans-Jurgen Busse, Torsten Seemann
We have determined the taxonomic position of two isolates of the genus Sphingobacterium. The first isolate, R-53603T, was obtained from purulent discharge from the toe of a cellulitis patient in Kuwait. Comparative 16S rRNA gene sequence analysis revealed 99.87% identity of R-53603T with environmental isolate P031 (= R-53745) originating from activated sludge in Singapore. Both isolates were phylogenetically positioned on the same sub-branch. Highest 16S rRNA gene sequence similarity was found with Sphingobacterium mizutaii LMG 8340T (98...
January 28, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28138393/clinical-features-and-treatment-of-vulvar-merkel-cell-carcinoma-a-systematic-review
#17
REVIEW
Austin Huy Nguyen, Ahmed I Tahseen, Adam M Vaudreuil, Gabriel C Caponetti, Christopher J Huerter
BACKGROUND: Merkel cell carcinoma is a rare and aggressive neoplasm originating from mechanoreceptor Merkel cells of the stratum basale of the epidermis. Cases affecting the vulva are exceedingly rare, with the currently available literature primarily in case report form. BODY: Systematic review of the PubMed database returned 17 cases of Merkel cell carcinoma affecting the vulva. Patients presented at a mean age of 59.6 years with a firm, mobile vulvar mass. Symptoms of pain, erythema, pruritus, edema, and ulceration have been reported...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28120309/microbial-production-of-astilbin-a-bioactive-rhamnosylated-flavanonol-from-taxifolin
#18
Nguyen Huy Thuan, Sailesh Malla, Nguyen Thanh Trung, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Jae Kyung Sohng
Flavonoids are plant-based polyphenolic biomolecules with a wide range of biological activities. Glycosylated flavonoids have drawn special attention in the industries as it improves solubility, stability, and bioactivity. Herein, we report the production of astilbin (ATN) from taxifolin (TFN) in genetically-engineered Escherichia coli BL21(DE3). The exogenously supplied TFN was converted to ATN by 3-O-rhamnosylation utilizing the endogeneous TDP-L-rhamnose in presence of UDP-glycosyltransferase (ArGT3, Gene Bank accession number: At1g30530) from Arabidopsis thaliana...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28117971/self-terminating-confinement-approach-for-large-area-uniform-monolayer-graphene-directly-over-si-siox-by-chemical-vapor-deposition
#19
Jinbo Pang, Rafael G Mendes, Pawel S Wrobel, Michal D Wlodarski, Huy Quang Ta, Liang Zhao, Lars Giebeler, Barbara Trzebicka, Thomas Gemming, Lei Fu, Zhongfan Liu, Juergen Eckert, Alicja Bachmatiuk, Mark H Rümmeli
To synthesize graphene by chemical vapor deposition (CVD) both in large area and with uniform layer number directly over Si/SiOx has proven challenging. The use of catalytically active metal substrates, in particular Cu, has shown far greater success and therefore is popular. That said, for electronics applications it requires a transfer procedure, which tends to damage and contaminate the graphene. Thus, the direct fabrication of uniform graphene on Si/SiOx remains attractive. Here we show a facile confinement CVD approach in which we simply "sandwich" two Si wafers with their oxide faces in contact to form uniform monolayer graphene...
January 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28111829/no-association-of-goal-directed-and-habitual-control-with-alcohol-consumption-in-young-adults
#20
Stephan Nebe, Nils B Kroemer, Daniel J Schad, Nadine Bernhardt, Miriam Sebold, Dirk K Müller, Lucie Scholl, Sören Kuitunen-Paul, Andreas Heinz, Michael A Rapp, Quentin J M Huys, Michael N Smolka
Alcohol dependence is a mental disorder that has been associated with an imbalance in behavioral control favoring model-free habitual over model-based goal-directed strategies. It is as yet unknown, however, whether such an imbalance reflects a predisposing vulnerability or results as a consequence of repeated and/or excessive alcohol exposure. We, therefore, examined the association of alcohol consumption with model-based goal-directed and model-free habitual control in 188 18-year-old social drinkers in a two-step sequential decision-making task while undergoing functional magnetic resonance imaging before prolonged alcohol misuse could have led to severe neurobiological adaptations...
January 23, 2017: Addiction Biology
keyword
keyword
49564
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"