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https://www.readbyqxmd.com/read/29770993/direct-evidence-of-lithium-ion-migration-in-resistive-switching-of-lithium-cobalt-oxide-nanobatteries
#1
Van Son Nguyen, Van Huy Mai, Pascale Auban Senzier, Claude Pasquier, Kang Wang, Marcelo J Rozenberg, Nathalie Brun, Katia March, François Jomard, John Giapintzakis, Cristian N Mihailescu, Evripides Kyriakides, Pavan Nukala, Thomas Maroutian, Guillaume Agnus, Philippe Lecoeur, Silvia Matzen, Pascal Aubert, Sylvain Franger, Raphaël Salot, Pierre-Antoine Albouy, David Alamarguy, Brahim Dkhil, Pascal Chrétien, Olivier Schneegans
Lithium cobalt oxide nanobatteries offer exciting prospects in the field of nonvolatile memories and neuromorphic circuits. However, the precise underlying resistive switching (RS) mechanism remains a matter of debate in two-terminal cells. Herein, intriguing results, obtained by secondary ion mass spectroscopy (SIMS) 3D imaging, clearly demonstrate that the RS mechanism corresponds to lithium migration toward the outside of the Lix CoO2 layer. These observations are very well correlated with the observed insulator-to-metal transition of the oxide...
May 17, 2018: Small
https://www.readbyqxmd.com/read/29767787/sleep-disordered-breathing-in-c57bl-6j-mice-with-diet-induced-obesity
#2
Thomaz Fleury Curado, Huy Pho, Slava Berger, Candela Caballero-Eraso, Mi-Kyung Shin, Luiz Ubirajara Sennes, Luu Pham, Alan R Schwartz, Vsevolod Y Polotsky
Obesity leads to sleep disordered breathing (SDB), as manifested by recurrent upper airway obstructions during sleep termed obstructive sleep apnea and carbon dioxide retention due to obesity hypoventilation. The objective of this work was to characterize breathing during sleep in C57BL6/J mice with diet-induced obesity. Arterial blood gas was measured in nine obese and nine lean mice during wakefulness. Nine male mice with diet induced obesity and six lean male C57BL/6J mice were head mounted with EEG and EMG electrodes...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29765820/a-comparative-analysis-of-endoscopic-assisted-transoral-and-transnasal-approaches-to-parapharyngeal-space-a-cadaveric-study
#3
Xicai Sun, Bo Yan, Huy Q Truong, Hamid Borghei-Razavi, Carl H Snyderman, Juan C Fernandez-Miranda
Background  Surgical resection of parapharyngeal space (PPS) tumors is very challenging. An endoscopic-assisted surgical approach to this region requires detailed and precise anatomic knowledge. The main purpose of this study is to describe and compare the detailed anatomy of the PPS via transnasal transpterygoid (TP) and endoscopic-assisted transoral (TO) approaches. Materials and Methods  Six fresh injected cadaver heads (12 sides) were prepared for dissection of the PPS via TP and TO approaches. Computed tomography (CT) with image-based navigation (Navigation System II; Stryker, Kalamazoo, Michigan, United States) was used to identify bony structures around the PPS...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29764999/targetable-bet-proteins-and-e2f1-dependent-transcriptional-program-maintains-the-malignancy-of-glioblastoma
#4
Liang Xu, Ye Chen, Anand Mayakonda, Lynnette Koh, Yuk Kien Chong, Dennis L Buckley, Edwin Sandanaraj, See Wee Lim, Ruby Yu-Tong Lin, Xin-Yu Ke, Mo-Li Huang, Jianxiang Chen, Wendi Sun, Ling-Zhi Wang, Boon Cher Goh, Huy Q Dinh, Dennis Kappei, Georg E Winter, Ling-Wen Ding, Beng Ti Ang, Benjamin P Berman, James E Bradner, Carol Tang, H Phillip Koeffler
Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers. However, the BET protein-dependent glioblastoma (GBM)-promoting transcriptional network remains elusive. Here, with mechanistic exploration of a next-generation chemical degrader of BET proteins (dBET6), we reveal a profound and consistent impact of BET proteins on E2F1- dependent transcriptional program in both differentiated GBM cells and brain tumor-initiating cells...
May 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29764902/secular-trend-seasonality-and-effects-of-a-community-based-intervention-on-neonatal-mortality-follow-up-of-a-cluster-randomised-trial-in-quang-ninh-province-vietnam
#5
Leif Eriksson, Nguyen T Nga, Dinh T Phuong Hoa, Duong M Duc, Anna Bergström, Lars Wallin, Mats Målqvist, Uwe Ewald, Tran Q Huy, Nguyen T Thuy, Tran Thanh Do, Pham T L Lien, Lars-Åke Persson, Katarina Ekholm Selling
BACKGROUND: Little is know about whether the effects of community engagement interventions for child survival in low-income and middle-income settings are sustained. Seasonal variation and secular trend may blur the data. Neonatal mortality was reduced in a cluster-randomised trial in Vietnam where laywomen facilitated groups composed of local stakeholders employing a problem-solving approach for 3 years. In this analysis, we aim at disentangling the secular trend, the seasonal variation and the effect of the intervention on neonatal mortality during and after the trial...
May 15, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29764270/drunk-decisions-alcohol-shifts-choice-from-habitual-towards-goal-directed-control-in-adolescent-intermediate-risk-drinkers
#6
Elisabeth Obst, Daniel J Schad, Quentin Jm Huys, Miriam Sebold, Stephan Nebe, Christian Sommer, Michael N Smolka, Ulrich S Zimmermann
BACKGROUND: Studies in humans and animals suggest a shift from goal-directed to habitual decision-making in addiction. We therefore tested whether acute alcohol administration reduces goal-directed and promotes habitual decision-making, and whether these effects are moderated by self-reported drinking problems. METHODS: Fifty-three socially drinking males completed the two-step task in a randomised crossover design while receiving an intravenous infusion of ethanol (blood alcohol level=80 mg%), or placebo...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29757514/two-novel-mutations-in-the-voltage-gated-sodium-channel-associated-with-knockdown-resistance-kdr-in-the-dengue-vector-aedes-aegypti-in-vietnam
#7
Nguyen Thi Kim Lien, Nguyen Thi Hong Ngoc, Nguyen Thu Hien, Nguyen Huy Hoang, Nguyen Thi Huong Binh
No abstract text is available yet for this article.
June 2018: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29756595/96-weeks-treatment-of-tenofovir-alafenamide-vs-tenofovir-disoproxil-fumarate-for-hepatitis-b-virus-infection
#8
Kosh Agarwal, Maurizia Brunetto, Wai Kay Seto, Young-Suk Lim, Scott Fung, Patrick Marcellin, Sang Hoon Ahn, Namiki Izumi, Wan-Long Chuang, Ho Bae, Manoj Sharma, Harry L A Janssen, Calvin Q Pan, Mustafa Kemal Çelen, Norihiro Furusyo, Dr Shalimar, Ki Tae Yoon, Huy Trinh, John F Flaherty, Anuj Gaggar, Audrey H Lau, Andrea L Cathcart, Lanjia Lin, Neeru Bhardwaj, Vithika Suri, G Mani Subramanian, Edward J Gane, Maria Buti, Henry L Y Chan
BACKGROUND & AIMS: Tenofovir alafenamide (TAF) is a new prodrug of tenofovir developed to treat patients with chronic hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF) through more efficient delivery of tenofovir to hepatocytes. In 48-week results from two ongoing, double-blind, randomized phase III trials, TAF was non-inferior to TDF in efficacy with improved renal and bone safety. We report 96-week outcomes for both trials. METHODS: In two international trials, patients with chronic HBV infection were randomized 2:1 to receive 25 mg TAF or 300 mg TDF in a double-blinded fashion...
April 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29755653/tumornext-lynch-mmr-a-comprehensive-next-generation-sequencing-assay-for-the-detection-of-germline-and-somatic-mutations-in-genes-associated-with-mismatch-repair-deficiency-and-lynch-syndrome
#9
Phillip N Gray, Pei Tsai, Daniel Chen, Sitao Wu, Jayne Hoo, Wenbo Mu, Bing Li, Huy Vuong, Hsiao-Mei Lu, Navanjot Batth, Sara Willett, Lisa Uyeda, Swati Shah, Chia-Ling Gau, Monalyn Umali, Carin Espenschied, Mike Janicek, Sandra Brown, David Margileth, Lavinia Dobrea, Lawrence Wagman, Huma Rana, Michael J Hall, Theodora Ross, Jonathan Terdiman, Carey Cullinane, Savita Ries, Ellen Totten, Aaron M Elliott
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can result in an extended time to diagnosis while depleting precious tumor specimens. Here we describe the analytical validation of a custom probe-based NGS tumor panel, TumorNext-Lynch-MMR, which generates a comprehensive genetic profile of both germline and somatic mutations that can accelerate and streamline the time to diagnosis and preserve specimen. TumorNext-Lynch-MMR can detect single nucleotide variants, small insertions and deletions in 39 genes that are frequently mutated in Lynch syndrome and colorectal cancer...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754431/expanding-severe-acute-respiratory-infection-sari-surveillance-beyond-influenza-the-process-and-data-from-1-year-of-implementation-in-vietnam
#10
Karen A Alroy, Trang Thuy Do, Phu Dac Tran, Tan Quang Dang, Long Ngoc Vu, Nga Thi Hang Le, Anh Duc Dang, Nghia Duy Ngu, Tu Huy Ngo, Phuong Mai Vu Hoang, Lan Trong Phan, Thuong Vu Nguyen, Long Thanh Nguyen, Thinh Viet Nguyen, Mai Quang Vien, Huy Xuan Le, Anh The Dao, Trieu Bao Nguyen, Duoc Tho Pham, Van Thi Tuyet Nguyen, Thanh Ngoc Pham, Binh Hai Phan, Brett Whitaker, Thuy Thi Thu Do, Phuong Anh Dao, S Arunmozhi Balajee, Anthony W Mounts
BACKGROUND: In 2016, as a component of the Global Health Security Agenda, the Vietnam Ministry of Health expanded its existing influenza sentinel surveillance for severe acute respiratory infections (SARI) to include testing for 7 additional viral respiratory pathogens. This article describes the steps taken to implement expanded SARI surveillance in Vietnam and reports data from 1 year of expanded surveillance. METHOD: The process of expanding the suite of pathogens for routine testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) included laboratory trainings, procurement/distribution of reagents, and strengthening and aligning SARI surveillance epidemiology practices at sentinel sites and regional institutes (RI)...
May 13, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29753815/neutropenia-among-patients-with-adenosine-deaminase-deficiency
#11
Vy Hong-Diep Kim, Anne Pham-Huy, Eyal Grunebaum
Neutropenia occurs frequently among adenosine deaminase-deficient patients, independent of infections, medications or chemotherapy, and might be among the presenting manifestations of the disease. Adenosine deaminase deficiency might directly affect myeloid development.
May 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29746850/battling-for-ribosomes-translational-control-at-the-forefront-of-the-antiviral-response
#12
REVIEW
Huy-Dung Hoang, Tyson E Graber, Tommy Alain
In the early stages of infection, gaining control of the cellular protein synthesis machinery including its ribosomes is the ultimate combat objective for a virus. To successfully replicate, viruses unequivocally need to usurp and redeploy this machinery for translation of their own mRNA. In response, the host triggers global shutdown of translation while paradoxically allowing swift synthesis of antiviral proteins as a strategy to limit collateral damage. This fundamental conflict at the level of translational control defines the outcome of infection...
May 7, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29745673/nucleophilic-substitutions-of-alcohols-in-high-levels-of-catalytic-efficiency
#13
Tanja Stach, Julia Dräger, Peter H Huy
A practical method for the nucleophilic substitution (S N ) of alcohols furnishing alkyl chlorides, bromides, and iodides under stereochemical inversion in high catalytic efficacy is introduced. The fusion of diethylcyclopropenone as a simple Lewis base organocatalyst and benzoyl chloride as a reagent allows notable turnover numbers up to 100. Moreover, the use of plain acetyl chloride as a stoichiometric promotor in an invertive S N -type transformation is demonstrated for the first time. The operationally straightforward protocol exhibits high levels of stereoselectivity and scalability and tolerates a variety of functional groups...
May 10, 2018: Organic Letters
https://www.readbyqxmd.com/read/29739912/early-cerebral-vein-after-endovascular-ischemic-stroke-treatment-predicts-symptomatic-reperfusion-hemorrhage
#14
Samuel C D Cartmell, Robyn L Ball, Rajani Kaimal, Nicholas A Telischak, Michael P Marks, Huy M Do, Robert L Dodd, Gregory W Albers, Maarten G Lansberg, Jeremy J Heit
BACKGROUND AND PURPOSE: Parenchymal hemorrhage (PH) after endovascular mechanical thrombectomy in acute ischemic stroke leads to worse outcomes. Better clinical and imaging biomarkers of symptomatic reperfusion PH are needed to identify patients at risk. We identified clinical and imaging predictors of reperfusion PH after endovascular mechanical thrombectomy with attention to early cerebral veins (ECVs) on postreperfusion digital subtraction angiography. METHODS: We performed a retrospective cohort study of consecutive acute ischemic stroke patients undergoing endovascular mechanical thrombectomy at our neurovascular referral center...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29734635/emissions-of-organic-compounds-from-produced-water-ponds-i-characteristics-and-speciation
#15
Seth N Lyman, Marc L Mansfield, Huy N Q Tran, Jordan D Evans, Colleen Jones, Trevor O'Neil, Ric Bowers, Ann Smith, Cara Keslar
We measured fluxes of methane, a suite of non-methane hydrocarbons (C2-C11), light alcohols, and carbon dioxide from oil and gas produced water storage and disposal ponds in Utah (Uinta Basin) and Wyoming (Upper Green River Basin) United States during 2013-2016. In this paper, we discuss the characteristics of produced water composition and air-water fluxes, with a focus on flux chamber measurements. In companion papers, we will (1) report on inverse modeling methods used to estimate emissions from produced water ponds, including comparisons with flux chamber measurements, and (2) discuss the development of mass transfer coefficients to estimate emissions and place emissions from produced water ponds in the context of all regional oil and gas-related emissions...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29733761/determination-of-low-solvent-concentration-by-nano-porous-silicon-photonic-sensors-using-volatile-organic-compound-method
#16
Huy Bui, Van Hoi Pham, Van Dai Pham, Thi Hong Cam Hoang, Thanh Binh Pham, Thuy Chi Do, Quang Minh Ngo, Thuy Van Nguyen
A vast majority of the organic solvents used in industry and laboratories are volatile, hazardous and toxic organic compounds, they are considered as a potent problem for human health and a cause of environmental pollution. Although analytical laboratory methods can determine extremely low solvent concentration, the sensing method with low cost and high sensitivity remains a conundrum. This paper presents and compares three methods (volatile organic compound (VOC), liquid drop and saturated vapour pressure) for determination of organic solvents in liquid environment by using photonic sensor based on nano-porous silicon (pSi) microcavity structures...
May 7, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29728909/association-between-dengue-severity-and-plasma-levels-of-dengue-specific-ige-and-chymase
#17
Miho Inokuchi, Shyam Prakash Dumre, Shusaku Mizukami, Mya Myat Ngwe Tun, Mohamed Gomaa Kamel, Dao Huy Manh, Le Hong Phuc, Nguyen Van Thuong, Tran Van An, Lan Nguyen Weiss, Tarek Turk, Tran Ngoc Dang, Vu Thi Que Huong, Kouichi Morita, Nguyen Tien Huy, Kenji Hirayama
There is no definitive predictor of dengue severity, and this has led to a very large number of unnecessary hospitalizations worldwide. Although mast cell mediators are believed to a play role in dengue severity, the lack of precise kinetic data demands further research on early predictors. We enrolled 111 patients with confirmed dengue and 85 with "other febrile illness" (OFI) in a hospital-based prospective study in Vietnam. Dengue patients were classified as level 1, 2, or 3 based on the clinical intervention received...
May 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29726708/antimicrobial-metabolites-from-a-marine-derived-actinomycete-streptomyces-sp-g278
#18
Duc Tuan Cao, Van Hieu Tran, Van Nam Vu, Huong Doan Thi Mai, Thi Hong Minh Le, Thi Quyen Vu, Hung Huy Nguyen, Van Minh Chau, Van Cuong Pham
Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Streptomyces sp. G278 led to the isolation of ten compounds, 1-10. Two compounds, 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene (1), and 3-hydroxyl-2-methylpyridine (2) were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound 3...
May 4, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29725615/nanostructure-osteopontin-and-mechanical-properties-of-calcitic-avian-eggshell
#19
Dimitra Athanasiadou, Wenge Jiang, Dina Goldbaum, Aroba Saleem, Kaustuv Basu, Michael S Pacella, Corinna F Böhm, Richard R Chromik, Maxwell T Hincke, Alejandro B Rodríguez-Navarro, Hojatollah Vali, Stephan E Wolf, Jeffrey J Gray, Khanh Huy Bui, Marc D McKee
Avian (and formerly dinosaur) eggshells form a hard, protective biomineralized chamber for embryonic growth-an evolutionary strategy that has existed for hundreds of millions of years. We show in the calcitic chicken eggshell how the mineral and organic phases organize hierarchically across different length scales and how variation in nanostructure across the shell thickness modifies its hardness, elastic modulus, and dissolution properties. We also show that the nanostructure changes during egg incubation, weakening the shell for chick hatching...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29724155/nerve-growth-factor-improves-the-outcome-of-type-2-diabetes-induced-hypotestosteronemia-and-erectile-dysfunction
#20
Yixing Wu, Chuntao Yang, Fuhui Meng, Fenglian Que, Wenxia Xiao, Huying Rao, Yan Wan, Hugh S Taylor, Lingeng Lu
Hypotestosterone and erectile dysfunction (ED) occur frequently in males with type 2 diabetes. It is still clinically challenging to manage diabetes-induced ED. Here, we conducted a 2-arm randomized clinical study and in vitro cell line experiments to investigate the effects of nerve growth factor (NGF) on serum testosterone and ED in diabetic males with sensorimotor polyneuropathy and to identify its underlying mechanisms. The analyses of serum total testosterone (TT) and free testosterone (FT), and 5-item version of the International Index of Erectile Function (IIEF-5) score at baseline and after treatment show increases in TT (3...
January 1, 2018: Reproductive Sciences
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