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https://www.readbyqxmd.com/read/28933762/effects-of-ambient-temperature-and-relative-humidity-on-subsurface-defect-detection-in-concrete-structures-by-active-thermal-imaging
#1
Quang Huy Tran, Dongyeob Han, Choonghyun Kang, Achintya Haldar, Jungwon Huh
Active thermal imaging is an effective nondestructive technique in the structural health monitoring field, especially for concrete structures not exposed directly to the sun. However, the impact of meteorological factors on the testing results is considerable and should be studied in detail. In this study, the impulse thermography technique with halogen lamps heat sources is used to detect defects in concrete structural components that are not exposed directly to sunlight and not significantly affected by the wind, such as interior bridge box-girders and buildings...
July 26, 2017: Sensors
https://www.readbyqxmd.com/read/28931241/association-of-a-novel-mutation-in-the-plasmodium-falciparum-chloroquine-resistance-transporter-with-decreased-piperaquine-sensitivity
#2
Sonia Agrawal, Kara A Moser, Lindsay Morton, Michael P Cummings, Ankita Parihar, Ankit Dwivedi, Amol C Shetty, Elliott F Drabek, Christopher G Jacob, Philipp P Henrich, Christian M Parobek, Krisada Jongsakul, Rekol Huy, Michele D Spring, Charlotte A Lanteri, Suwanna Chaorattanakawee, Chanthap Lon, Mark M Fukuda, David L Saunders, David A Fidock, Jessica T Lin, Jonathan J Juliano, Christopher V Plowe, Joana C Silva, Shannon Takala-Harrison
Background: Amplified copy number in the plasmepsin II/III genes within Plasmodium falciparum has been associated with decreased sensitivity to piperaquine. To examine this association and test whether additional loci might also contribute, we performed a genome-wide association study of ex vivo P. falciparum susceptibility to piperaquine. Methods: Plasmodium falciparum DNA from 183 samples collected primarily from Cambodia was genotyped at 33716 genome-wide single nucleotide polymorphisms (SNPs)...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28929342/perception-of-originator-biologics-and-biosimilars-a-survey-among-belgian-rheumatoid-arthritis-patients-and-rheumatologists
#3
Eline van Overbeeke, Birgit De Beleyr, Jan de Hoon, Rene Westhovens, Isabelle Huys
BACKGROUND: Among patients and rheumatologists, current knowledge and perception of biosimilars in comparison with originator biologics is unknown. OBJECTIVES: The aim of this study was to investigate this knowledge and perception in Belgian rheumatologists and rheumatoid arthritis (RA) patients. METHODS: Anonymous web surveys were conducted in Belgian RA patients (n = 121) and rheumatologists (n = 41) during the period January-March 2016...
September 19, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28924006/the-neural-basis-of-aversive-pavlovian-guidance-during-planning
#4
Níall Lally, Quentin J M Huys, Neir Eshel, Paul Faulkner, Peter Dayan, Jonathan P Roiser
Important real-world decisions are often arduous as they frequently involve sequences of choices, with initial selections affecting future options. Evaluating every possible combination of choices is computationally intractable, particularly for longer multi-step decisions. Therefore, humans frequently employ heuristics to reduce the complexity of decisions. We recently used a goal-directed planning task to demonstrate the profound behavioral influence and ubiquity of one such shortcut, namely aversive pruning, a reflexive Pavlovian process that involves neglecting parts of the decision space residing beyond salient negative outcomes...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28914373/the-therapeutic-effect-of-probiotics-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#5
Abdelrahman Tarek Mohammed, Mohammed Khattab, Ali Mahmoud Ahmed, Tarek Turk, Nora Sakr, Adham M Khalil, Mohamed Abdelhalim, Bisher Sawaf, Kenji Hirayama, Nguyen Tien Huy
Rheumatoid arthritis is an autoimmune disease in which probiotics appears to have an immune modulating action along with decreased inflammatory process. Therefore, we aim to investigate the efficacy of probiotics as an adjuvant therapy for rheumatoid arthritis. A comprehensive literature search was performed using nine databases including PubMed and Web of Science. Interesting data was extracted and meta-analyzed. We assessed the risk of bias using Cochrane Collaboration's tool. The protocol was registered in PROSPERO (CRD 42016036769)...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28913696/clinicopathological-risk-factors-for-distant-metastasis-in-differentiated-thyroid-carcinoma-a-meta-analysis
#6
REVIEW
Huy Gia Vuong, Uyen N P Duong, Thong Quang Pham, Hung Minh Tran, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh, Tetsuo Kondo
INTRODUCTION: Distant metastasis (DM) is not a frequent event in differentiated thyroid carcinoma (DTC) but has an adverse impact on mortality of patients with DTC. In the current study, we aimed to conduct a comprehensive systematic review and meta-analysis to investigate the risk factors for DM in DTCs and for each histological subtype. METHODS: Five electronic databases were searched from inception to December 2016 for relevant articles. Pooled odd ratios and 95% confidence interval were calculated using random-effect model...
September 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28901948/ultrathin-mose2-n-doped-carbon-composite-nanospheres-for-stable-na-ion-storage
#7
Guichong Jia, Huanwen Wang, Dongliang Chao, Haiyong He, Nguyen Huy Tiep, Yongqi Zhang, Zheng Zhang, Hongjin Fan
Two-dimensional (2D) transition metal dichalcogenides are widely studied as anode materials for metal ion batteries. This application requires high electric conductivity which can be achieved by forming composites with conductive carbon. In this work, we demonstrate the creation of nanospheres composed of Mo-based thin nanosheets (MoS2, MoSe2 and Mo2C) uniform embedded within a N-doped carbon matrix. Using MoSe2/N-doped carbon nanospheres as example, we investigate in deails the electrochemical property in Na ion storage and reveal the advantage over previously reported MoSe2 electrodes (higher capacity and improved capacity retention up to 500 cycles)...
September 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28892478/continuous-robust-sound-event-classification-using-time-frequency-features-and-deep-learning
#8
Ian McLoughlin, Haomin Zhang, Zhipeng Xie, Yan Song, Wei Xiao, Huy Phan
The automatic detection and recognition of sound events by computers is a requirement for a number of emerging sensing and human computer interaction technologies. Recent advances in this field have been achieved by machine learning classifiers working in conjunction with time-frequency feature representations. This combination has achieved excellent accuracy for classification of discrete sounds. The ability to recognise sounds under real-world noisy conditions, called robust sound event classification, is an especially challenging task that has attracted recent research attention...
2017: PloS One
https://www.readbyqxmd.com/read/28892235/beclabuvir-in-combination-with-asunaprevir-and-daclatasvir-for-hepatitis-c-virus-genotype-1-infection-a-systematic-review-and-meta-analysis
#9
Ali Mahmoud Ahmed, Mohamed Fahmy Doheim, Omar Mohamed Mattar, Nourin Ali Sherif, Duy Hieu Truong, Pham Thi Le Hoa, Kenji Hirayama, Nguyen Tien Huy
Daclatasvir, asunaprevir, and beclabuvir are direct-acting antivirals for patients with hepatitis C virus genotype 1 infection. This systematic review and meta-analysis investigating the efficacy and safety of this three-drug combination in HCV genotype 1 infection. Eleven electronic search engines were searched for relevant publications. Studies were screened for eligibility and data was extracted. The outcomes were pooled as event rate and risk ratio. The protocol was registered in PROSPERO (CRD42017054391)...
September 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28892187/patient-satisfaction-with-health-care-services-at-a-national-institute-of-ophthalmology
#10
Nguyen Van Huy, Nguyen Ngoc Dung, Cao Duc Thang, Le Thuy Hanh
Little is known about how patients in developing countries, such as Vietnam, are satisfied with eye care services. The purpose of this study was to assess the satisfaction with health services and its associated factors among patients attending a national institute of ophthalmology in Vietnam. In a cross-sectional study utilizing quantitative methods, 500 inpatients and their relatives attending a national institute of ophthalmology in Vietnam were approached for data collection. The results indicated that under 50% of the patients were satisfied with eye care services...
September 11, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28890504/an-alarmingly-high-proportion-of-anti-retroviral-drugs-resistant-hiv-1-infection-among-high-risk-groups-in-central-vietnam-a-sub-study-of-the-national-sentinel-survey
#11
Hung Thai Do, Dong Thanh Nguyen, Lan Anh Thi Nguyen, Duong Huy Do, Huy Xuan Le, Xuan Mai Thi Trinh, Hong Vy Nu Ton, Ikumi Sawada, Noriko Kitamura, Nhat Minh Le, Keisuke Yoshihara, Thu Huong Thi Phan, Chien Trong Bui, Koya Ariyoshi, Lay Myint Yoshida
We investigated the prevalence of HIV drug resistance among high risk groups such as injecting drug user (IDU), female sex worker (FSW) and men having sex with men (MSM) in central Vietnam. We used HIV positive samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays and the positive samples were further tested for HIV viral load and drug resistant mutations by in-house assays. Drug resistant mutations (DRMs) were determined using the Stanford University online sequence analysis tool...
September 11, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28890153/medicinal-plants-for-in-vitro-antiplasmodial-activities-a-systematic-review-of-literature
#12
REVIEW
Martha Tibebu Lemma, Ali Mahmoud Ahmed, Mohamed Tamer Elhady, Huyen Thi Ngo, Tran Le-Huy Vu, To Kim Sang, Eduardo Campos-Alberto, Abdelrahman Sayed, Shusaku Mizukami, Kesara Na-Bangchang, Nguyen Tien Huy, Kenji Hirayama, Juntra Karbwang
The increasing resistance of malaria to drugs raise the need to new antimalarial agents. Antiplasmodial herbs and their active compounds are the most promising source the new antimalarial agents. This study aimed to identify the medicinal plants with very good in vitro antiplasmodial activities, with half-maximal inhibitory concentration (IC50)≤1μg/ml, and to determine trends in the process of screening their antiplasmodial activities. A total of 58 reports published in the English language were retrieved from the bibliographical databases...
September 7, 2017: Parasitology International
https://www.readbyqxmd.com/read/28883032/screening-for-atrial-fibrillation-in-hospitalised-geriatric-patients
#13
Rene Tavernier, Michael Wolf, Vikas Kataria, Tom Phlips, Ruben Huys, Philippe Taghji, Ruan Louw, Raf Van Hoeyweghen, Yves Vandekerckhove, Sébastien Knecht, Mattias Duytschaever
OBJECTIVES: To assess whether daily short-term rhythm strip recordings on top of routine clinical care could increase the atrial fibrillation (AF) detection rate in the hospitalised elderly. METHODS: A hand-held device storing a bipolar ECG during 1 min was used for daily rhythm recording in hospitalised elderly patients. RESULTS: During 2 months, all patients admitted to the Department of Geriatric Medicine were screened (n=327). Five patients refused to participate in the study and 70 patients were unable to hold the device due to severe mental (n=46) or motor impairment (n=24)...
September 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28880019/market-access-of-spinraza-nusinersen-for-spinal-muscular-atrophy-intellectual-property-rights-pricing-value-and-coverage-considerations
#14
S Simoens, I Huys
No abstract text is available yet for this article.
September 7, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28878679/time-investment-in-drug-supply-problems-by-flemish-community-pharmacies
#15
Elfi De Weerdt, Steven Simoens, Minne Casteels, Isabelle Huys
Introduction: Drug supply problems are a known problem for pharmacies. Community and hospital pharmacies do everything they can to minimize impact on patients. This study aims to quantify the time spent by Flemish community pharmacies on drug supply problems. Materials and Methods: During 18 weeks, employees of 25 community pharmacies filled in a template with the total time spent on drug supply problems. The template stated all the steps community pharmacies could undertake to manage drug supply problems. Results: Considering the median over the study period, the median time spent on drug supply problems was 25 min per week, with a minimum of 14 min per week and a maximum of 38 min per week...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28872845/iron-iii-metallacryptand-and-metallacryptate-assemblies-derived-from-aroylbis-n-n-diethylthioureas
#16
Chien Thang Pham, Hung Huy Nguyen, Adelheid Hagenbach, Ulrich Abram
The reaction of isophthaloylbis(N,N-diethylthiourea), H2L(1), with FeCl3·6H2O gives the dinuclear tris-complex [Fe2(L(1))3] (5), possessing a cryptand-like structure. A similar reaction with the ligand 2,6-dipicolinoylbis(N,N-diethylthiourea), H2L(2), however, results in the formation of the anionic, mononuclear Fe(III) complex [Fe(L(2))2](-) (6), which could be isolated as its "Tl(+) salt" by the subsequent addition of Tl(NO3). A tighter view to the solid state structure of the obtained product, however, characterizes compound 6 as a one-dimensional coordination polymer, in which four-coordinate Tl(+) ions connect the {[Fe(L(2))2](-)} units to infinite chains...
September 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28870011/inhibitory-effect-of-an-ethanol-extract-of-a-rice-bran-mixture-including-angelica-gigas-cnidium-officinale-artemisia-princeps-and-camellia-sinensis-on-brucella-abortus-uptake-by-professional-and-non-professional-phagocytes
#17
Huynh Tan Hop, Lauren Togonon Arayan, Alisha Wehdnesday Bernardo Reyes, Tran Xuan Ngoc Huy, Eun Jin Baek, WonGi Min, Hu Jang Lee, Chun Hee Lee, Man Hee Rhee, Suk Kim
In this study, we evaluated the inhibitory effect of a rice bran mixture extract (RBE) on Brucella (B.) abortus pathogenesis in professional (RAW 264.7) and non-professional (HeLa) phagocytes. We fermented the rice bran mixture and then extracted with 50% ethanol followed by gas chromatography-mass spectrometry to identify components in RBE. Our results clearly showed that RBE caused a significant reduction in the adherence of B. abortus in both cell lines. Furthermore, analysis of phagocytic signaling proteins by Western blot revealed that RBE pretreatment resulted in inhibition of phosphorylation of JNK, ERK and p38, leading to decline of internalization compared with the controls...
September 5, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28868548/developing-antineoplastic-agents-that-target-peroxisomal-enzymes-cytisine-linked-isoflavonoids-as-inhibitors-of-hydroxysteroid-17-beta-dehydrogenase-4-hsd17b4
#18
Mykhaylo S Frasinyuk, Wen Zhang, Przemyslaw Wyrebek, Tianxin Yu, Xuehe Xu, Vitaliy M Sviripa, Svitlana P Bondarenko, Yanqi Xie, Huy X Ngo, Andrew J Morris, James L Mohler, Michael V Fiandalo, David S Watt, Chunming Liu
Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A pull-down assay using a biologically active, biotin-modified CLIF identified the target of these agents as the bifunctional peroxisomal enzyme, hydroxysteroid 17β-dehydrogenase-4 (HSD17B4). Additional studies with truncated versions of HSD17B4 established that CLIFs specifically bind the C-terminus of HSD17B4 and selectively inhibited the enoyl CoA hydratase but not the d-3-hydroxyacyl CoA dehydrogenase activity...
September 20, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28866123/a-systematic-review-finds-underreporting-of-ethics-approval-informed-consent-and-incentives-in-clinical-trials
#19
Ly Quoc Trung, Mostafa Ebraheem Morra, Nguyen Duc Truong, Tarek Turk, Ahmed Elshafie, Amr Foly, Dao Ngoc Hien Tam, Ahmed Iraqi, Trinh Thi Hong Van, Ahmed Elgebaly, Tran Nhu Ngoc, Tran Le Huy Vu, Ngan Thy Chu, Kenji Hirayama, Juntra Karbwang, Nguyen Tien Huy
OBJECTIVES: In this study, we aim to review researchers' reporting practices of the ethics statement, financial incentives, and local ethical committees' profile in their clinical trials. STUDY DESIGN AND SETTING: A systematic search was done through top ranked 50 medical journals (Scimago Ranking) to retrieve 2000 latest publications. Only primary clinical trials were included with no restriction to language or participants. RESULT: Among the 927 included trials, 14 (1...
August 30, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28863132/a-novel-rapid-and-reproducible-flow-cytometric-method-for-optimization-of-transfection-efficiency-in-cells
#20
Stefanie Homann, Christian Hofmann, Aleksandr M Gorin, Huy Cong Xuan Nguyen, Diana Huynh, Phillip Hamid, Neil Maithel, Vahe Yacoubian, Wenli Mu, Athanasios Kossyvakis, Shubhendu Sen Roy, Otto Orlean Yang, Theodoros Kelesidis
Transfection is one of the most frequently used techniques in molecular biology that is also applicable for gene therapy studies in humans. One of the biggest challenges to investigate the protein function and interaction in gene therapy studies is to have reliable monospecific detection reagents, particularly antibodies, for all human gene products. Thus, a reliable method that can optimize transfection efficiency based on not only expression of the target protein of interest but also the uptake of the nucleic acid plasmid, can be an important tool in molecular biology...
2017: PloS One
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