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https://www.readbyqxmd.com/read/28803076/palliative-care-in-vietnam-long-term-partnerships-yield-increasing-access
#1
Eric L Krakauer, Dang Huy Quoc Thinh, Quach Thanh Khanh, Hoang Thi Mong Huyen, Tran Diep Tuan, Than Ha Ngoc The, Do Duy Cuong, Tran Van Thuan, Nguyen Phi Yen, Pham Van Anh, Nguyen Thi Phuong Cham, Kathleen P Doyle, Nguyen Thi Hai Yen, Luong Ngoc Khue
Palliative care began in Vietnam in 2001, but steady growth in palliative care services and education commenced several years later when partnerships for ongoing training and technical assistance by committed experts were created with the Ministry of Health (MoH), major public hospitals, and medical universities. An empirical analysis of palliative care need by the MoH in 2006 was followed by national palliative care clinical guidelines, initiation of clinical training for physicians and nurses, and revision of opioid prescribing regulations...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28802704/early-miscarriage-rate-in-lean-polycystic-ovary-syndrome-women-after-euploid-embryo-transfer-a-matched-pair-study
#2
Lu Luo, Fang Gu, Huying Jie, Chenhui Ding, Qiang Zhao, Qiong Wang, Canquan Zhou
The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed...
July 29, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28792897/partial-membership-latent-dirichlet-allocation-for-soft-image-segmentation
#3
Chao Chen, Alina Zare, Huy N Trinh, Gbenga O Omotara, J Tory Cobb, Timotius A Lagaunne
Topic models (e.g., pLSA, LDA, sLDA) have been widely used for segmenting imagery. However, these models are confined to crisp segmentation, forcing a visual word (i.e., an image patch) to belong to one and only one topic. Yet, there are many images in which some regions cannot be assigned a crisp categorical label (e.g., transition regions between a foggy sky and the ground or between sand and water at a beach). In these cases, a visual word is best represented with partial memberships across multiple topics...
August 4, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28781214/fifty-shades-of-belgian-gray-the-prevalence-of-bdsm-related-fantasies-and-activities-in-the-general-population
#4
Lien Holvoet, Wim Huys, Violette Coppens, Jantien Seeuws, Kris Goethals, Manuel Morrens
BACKGROUND: Bondage and discipline, dominance and submission, and sadism and masochism (BDSM) is gaining popularity through the mainstream media. Nevertheless, very little is known about the prevalence of BDSM-related fantasies and activities in the general population. AIM: To determine the prevalence of BDSM fantasies and behavioral involvement in four different age groups of the general population in Belgium. METHODS: By use of a cross-sectional survey questionnaire, the level of interest in several BDSM-related activities was investigated in a sample representative of the general Belgian population (N = 1,027)...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28780930/repurposing-drugs-in-oncology-next-steps
#5
Ciska Verbaanderd, Lydie Meheus, Isabelle Huys, Pan Pantziarka
The repurposing of existing non-cancer drugs is a potential source of new treatment options for cancer patients with high unmet medical needs. While scientific research is progressing rapidly in the field of drug repurposing, the implementation of drug repurposing still faces important financial and regulatory hurdles that should be addressed to optimise clinical adoption.
August 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28777026/letter-to-the-editor-rectus-capitis-lateralis-muscle-anatomical-relationships-in-posterior-and-anterior-approaches-to-the-jugular-foramen
#6
Sukhdeep S Jhawar, Maximiliano Nunez, Paolo Pacca, Daniel Seclen Voscoboinik, Huy Q Truong
No abstract text is available yet for this article.
August 4, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28768818/sofia-intermediate-catheter-and-the-snake-technique-safety-and-efficacy-of-the-sofia-catheter-without-guidewire-or-microcatheter-construct
#7
Jeremy J Heit, Johnny Hy Wong, Adrienne M Mofaff, Nicholas A Telischak, Robert L Dodd, Michael P Marks, Huy M Do
BACKGROUND: Neurointerventional surgeries (NIS) benefit from supportive endovascular constructs. Sofia is a soft-tipped, flexible, braided single lumen intermediate catheter designed for NIS. Sofia advancement from the cervical to the intracranial circulation without a luminal guidewire or microcatheter construct has not been described. OBJECTIVE: To evaluate the efficacy and safety of the new Sofia Non-wire Advancement techniKE (SNAKE) for advancement of the Sofia into the cerebral circulation...
August 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28764339/an-adaptive-solution-to-the-chemical-master-equation-using-tensors
#8
Huy D Vo, Roger B Sidje
Solving the chemical master equation directly is difficult due to the curse of dimensionality. We tackle that challenge by a numerical scheme based on the quantized tensor train (QTT) format, which enables us to represent the solution in a compressed form that scales linearly with the dimension. We recast the finite state projection in this QTT framework and allow it to expand adaptively based on proven error criteria. The end result is a QTT-formatted matrix exponential that we evaluate through a combination of the inexact uniformization technique and the alternating minimal energy algorithm...
July 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28763064/strong-seduction-impulsivity-and-the-impact-of-contextual-cues-on-instrumental-behavior-in-alcohol-dependence
#9
C Sommer, M Garbusow, E Jünger, S Pooseh, N Bernhardt, J Birkenstock, D J Schad, B Jabs, T Glöckler, Q M Huys, A Heinz, M N Smolka, U S Zimmermann
Alcohol-related cues acquire incentive salience through Pavlovian conditioning and then can markedly affect instrumental behavior of alcohol-dependent patients to promote relapse. However, it is unclear whether similar effects occur with alcohol-unrelated cues. We tested 116 early-abstinent alcohol-dependent patients and 91 healthy controls who completed a delay discounting task to assess choice impulsivity, and a Pavlovian-to-instrumental transfer (PIT) paradigm employing both alcohol-unrelated and alcohol-related stimuli...
August 1, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28760555/rhythmicity-and-plasticity-of-digestive-physiology-in-a-euryhaline-teleost-fish-permit-trachinotus-falcatus
#10
Carlo C Lazado, Per Bovbjerg Pedersen, Huy Quang Nguyen, Ivar Lund
Digestive physiology is considered to be under circadian control, but there is little evidence in teleost fish. The present study explored the rhythmicity and plasticity to feeding schedules of enzymatic digestion in a candidate aquaculture fish, the permit (Trachinotus falcatus). The first experiment identified the rhythms of digestive factors throughout the light-dark (LD) cycle. Gastric luminal pH and pepsin activity showed significant daily variation albeit not rhythmic. These dynamic changes were likewise observed in several digestive enzymes, in which the activities of intestinal protease, chymotrypsin and lipase exhibited significant daily rhythms...
July 29, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28758549/pipeline-embolization-device-retraction-and-foreshortening-after-internal-carotid-artery-blister-aneurysm-treatment
#11
Jeremy J Heit, Nicholas A Telischak, Huy M Do, Robert L Dodd, Gary K Steinberg, Michael P Marks
Background Subarachnoid hemorrhage (SAH) secondary to rupture of a blister aneurysm (BA) results in high morbidity and mortality. Endovascular treatment with the pipeline embolization device (PED) has been described as a new treatment strategy for these lesions. We present the first reported case of PED retraction and foreshortening after treatment of a ruptured internal carotid artery (ICA) BA. Case description A middle-aged patient presented with SAH secondary to ICA BA rupture. The patient was treated with telescoping PED placement across the BA...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28756116/selection-of-antigenic-variants-of-an-h5n1-highly-pathogenic-avian-influenza-virus-in-vaccinated-chickens
#12
Lam Thanh Nguyen, Tatsuya Nishi, Shintaro Shichinohe, Duc-Huy Chu, Takahiro Hiono, Keita Matsuno, Masatoshi Okamatsu, Hiroshi Kida, Yoshihiro Sakoda
Vaccination-primed immunity in poultry has been suggested for selection of antigenically drifted highly pathogenic avian influenza viruses (HPAIVs). In this study, we performed two consecutive passage studies of an H5N1 HPAIV in vaccinated chickens, namely, study-I and study-II, to select antigenic variants under immune pressure from the vaccination. In study-I, nine consecutive passages of a wild-type H5N1 HPAIV were carried out in chickens vaccinated with the homologous challenge strain. Antigenically drifted variants with mutations at position 179 in the hemagglutinin (HA) were selected after three passages...
July 27, 2017: Virology
https://www.readbyqxmd.com/read/28753615/clustering-infection-of-hepatitis-b-virus-genotype-b4-among-residents-in-vietnam-and-its-genomic-characters-both-intra-and-extra-family
#13
Junko Matsuo, Son Huy Do, Chikako Yamamoto, Shintaro Nagashima, Channarena Chuon, Keiko Katayama, Kazuaki Takahashi, Junko Tanaka
Vietnam has a high rate of hepatitis B virus (HBV) infection and a high mortality rate from hepatocellular carcinoma. We performed a detailed genetic analysis of 48 residents and four families from Binh Thuan Province, a southern coastal area of Vietnam. The route of infection and genomic characteristics related to hepatocellular carcinoma (HCC) were studied in HBV spread among carriers that we detected in our previous hepatitis survey. The HBV genotype was B4 in 91.7% and C1 in 8.3% of the cases. The intra-family's HBV sequence homology was high at 96...
2017: PloS One
https://www.readbyqxmd.com/read/28752875/multimode-smartphone-biosensing-the-transmission-reflection-and-intensity-spectral-tri-analyzer
#14
Kenneth D Long, Elizabeth V Woodburn, Huy M Le, Utsav K Shah, Steven S Lumetta, Brian T Cunningham
We demonstrate a smartphone-integrated handheld detection instrument capable of utilizing the internal rear-facing camera as a high-resolution spectrometer for measuring the colorimetric absorption spectrum, fluorescence emission spectrum, and resonant reflection spectrum from a microfluidic cartridge inserted into the measurement light path. Under user selection, the instrument gathers light from either the white "flash" LED of the smartphone or an integrated green laser diode to direct illumination into a liquid test sample or onto a photonic crystal biosensor...
July 28, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28749771/seroprevalence-of-brucellosis-among-patients-attending-a-district-hospital-in-rwanda
#15
James Gafirita, George Kiiza, Angelique Murekatete, Leonard L Ndahayo, John Tuyisenge, Vedaste Mashengesho, Rudoviko Ruhirwa, Theogene Nyandwi, Brenda Asiimwe-Kateera, Vedaste Ndahindwa, Kato J Njunwa
Studies on human brucellosis in Rwanda are scarce, and the incidence is likely to be higher than official estimates. In a recent study using Rose Bengal Test (RBT) on women who had aborted or had still births in Huye district, 25% were Brucella seroprevalent. Thus, purpose of the present study was to investigate the Brucella seroprevalence in patients presenting with the key signs and symptoms of brucellosis. Cross-sectional study was done in Nyagatare District in the Eastern Province of Rwanda. A total of 198 patients were recruited from Nyagatare District Hospital, blood samples were collected, and sera analyzed with RBT...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28748310/long-term-outcome-of-adenosine-deaminase-deficient-patients-a-single-center-experience
#16
Ori Scott, Vy Hong-Diep Kim, Brenda Reid, Anne Pham-Huy, Adelle R Atkinson, Alessandro Aiuti, Eyal Grunebaum
PURPOSE: Inherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene therapy (GT). Here, we describe the long-term benefits of these treatments. METHODS: Survival, infections, systemic sequelae, and laboratory assessments were recorded for all ADA-deficient SCID patients, managed at a single center since 1985, who survived 5 or more years following treatment...
July 26, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28743795/capturing-protein-communities-by-structural-proteomics-in-a-thermophilic-eukaryote
#17
Panagiotis L Kastritis, Francis J O'Reilly, Thomas Bock, Yuanyue Li, Matt Z Rogon, Katarzyna Buczak, Natalie Romanov, Matthew J Betts, Khanh Huy Bui, Wim J Hagen, Marco L Hennrich, Marie-Therese Mackmull, Juri Rappsilber, Robert B Russell, Peer Bork, Martin Beck, Anne-Claude Gavin
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive. Here, we show that crude cellular extracts of a eukaryotic thermophile, Chaetomium thermophilum, retain basic principles of cellular organization. Using a structural proteomics approach, we simultaneously characterized the abundance, interactions, and structure of a third of the C...
July 25, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28736677/no-evidence-of-on-farm-circulation-of-avian-influenza-h5-subtype-in-ca-mau-province-southern-vietnam-march-2016-january-2017
#18
Nguyen Thi Le Thanh, Nguyen Ha Thao Vy, Huynh Thi Ai Xuyen, Huynh Thi Phuong, Phung Ngoc Tuyet, Nguyen Thanh Huy, Benjamin Nguyen-Van-Yen, Ha Minh Lam, Maciej F Boni
BACKGROUND: Subtype H5N1 avian influenza viruses, both high pathogenicity and low pathogenicity, have been enzootic in Vietnam since 2001.  The viruses are readily identified at live bird markets, but virus prevalence on smallholder poultry is typically zero or very low.  If the true direction of the viral transmission chain is farm to market, it is unknown why farm prevalence should be low when market prevalence is moderate to high. METHODS: We established a cohort of 50 smallholder poultry farms in Ca Mau province in the Mekong Delta region of Vietnam...
May 5, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28733260/significant-hepatic-fibrosis-among-treatment-na%C3%A3-ve-chronic-hbv-with-elevated-hbv-dna-and-normal-alanine-aminotransferase
#19
Robert J Wong, Angelica Le, My T Nguyen, Huy N Trinh, Andrew Huynh, My Tops Ly, Huy A Nguyen, Khanh K Nguyen, Jenny Yang, Ruel T Garcia, Brian Levitt, Eduardo da Silveira, Robert G Gish
No abstract text is available yet for this article.
July 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28729702/structure-of-general-population-antibody-titer-distributions-to-influenza-a-virus
#20
Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F Boni
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity...
July 20, 2017: Scientific Reports
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