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https://www.readbyqxmd.com/read/29163168/atheroregressive-potential-of-the-treatment-with-a-chimeric-monoclonal-antibody-against-sulfated-glycosaminoglycans-on-pre-existing-lesions-in-apolipoprotein-e-deficient-mice
#1
Victor Brito, Katia Mellal, Karina F Zoccal, Yosdel Soto, Liliane Ménard, Roger Sarduy, Lucia H Faccioli, Huy Ong, Ana M Vázquez, Sylvie Marleau
The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation. Administration of chP3R99, a chimeric mouse/human monoclonal antibody inducing an anti-idiotypic network response against glycosaminoglycans was previously shown to prevent atherosclerotic lesion progression, yet its effect in the late-stage progression of lesions remains unknown. This study investigated the effect of chP3R99 at a late stage of disease development in apolipoprotein E-deficient mice and the vascular mechanisms involved...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162915/extensive-gene-flow-of-white-backed-planthopper-in-the-greater-mekong-subregion-as-revealed-by-microsatellite-markers
#2
Yanqiong Yin, Xiangyong Li, Dong Chu, Xueqing Zhao, Khay Sathya, Bounneuang Douangboupha, Mu Mu Kyaw, Manita Kongchuensin, Apirusht Somrith, Vinh Vien Ngo, Huy Chung Nguyen, Shicai Shen, Shufang Liu, Aidong Chen
The white-backed planthopper (WBPH), Sogatella furcifera (Horváth), is a destructive pest of rice in the Greater Mekong Subregion (GMS) countries including Cambodia, Laos, Myanmar, Thailand, Vietnam, and China's Yunnan Province. Our previous study not only confirmed the immigration sources of the WBPH in China's Yunnan Province were from Myanmar, Vietnam, and Laos, but also indicated that Cambodia was likely an additional migration source. To further clarify the migration sources and patterns of the WBPH in the GMS, we investigated the genetic structure of 42 WBPH populations using microsatellite loci markers...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29159282/ultrafast-direct-electron-transfer-at-organic-semiconductor-and-metal-interfaces
#3
Bo Xiang, Yingmin Li, C Huy Pham, Francesco Paesani, Wei Xiong
The ability to control direct electron transfer can facilitate the development of new molecular electronics, light-harvesting materials, and photocatalysis. However, control of direct electron transfer has been rarely reported, and the molecular conformation-electron dynamics relationships remain unclear. We describe direct electron transfer at buried interfaces between an organic polymer semiconductor film and a gold substrate by observing the first dynamical electric field-induced vibrational sum frequency generation (VSFG)...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29158964/ginsenoside-rk1-bioactivity-a-systematic-review
#4
Abdelrahman Elshafay, Ngo Xuan Tinh, Samar Salman, Yara Saber Shaheen, Eman Bashir Othman, Mohamed Tamer Elhady, Aswin Ratna Kansakar, Linh Tran, Le Van, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Out of the 156 papers identified, we retrieved 28 eligible papers in the first skimming phase of research...
2017: PeerJ
https://www.readbyqxmd.com/read/29157311/peripheral-and-local-predictive-immune-signatures-identified-in-a-phase-ii-trial-of-ipilimumab-with-carboplatin-paclitaxel-in-unresectable-stage-iii-or-stage-iv-melanoma
#5
Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis, Paméla Thébault, Shirin Kazemi, Jennifer E Friedmann, Jeanne Dionne, Jean-François Cailhier, Karl Bélanger, Jean-Pierre Ayoub, Huy Le, Caroline Lambert, Jida El-Hajjar, Léon C van Kempen, Alan Spatz, Wilson H Miller
BACKGROUND: Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit from treatment are needed. This phase II trial combined ipilimumab with carboplatin/paclitaxel (CP) to assess its safety, efficacy, and to search for peripheral and tumor-based predictive biomarkers. METHODS: Thirty patients with untreated unresectable/metastatic melanoma were treated with ipilimumab and CP...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29154366/generalization-of-conditioned-auditory-fear-is-regulated-by-maternal-effects-on-ventral-hippocampal-synaptic-plasticity
#6
Huy-Bin Nguyen, Carine Parent, Yiu Chung Tse, Tak Pan Wong, Michael J Meaney
Maternal care shapes individual differences in fear-associated neural circuitry. In rats, maternal licking and grooming (LG) in early life regulates ventral hippocampal (VH) function and plasticity in adulthood, but its consequent effect on the regulation of fear memories remains unknown. We report an effect of maternal care on generalization of learned fear, such that offspring of high LG mothers express generalized fear responses when confronted with neutral stimuli following auditory fear conditioning. These animals simultaneously display a reduction in the magnitude of VH-LTP expressed and reduced input-output transformation in Schaffer Collateral synapses...
November 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29153195/proenkephalin-in-heart-failure
#7
REVIEW
Daniel Chu Siong Chan, Thong Huy Cao, Leong Loke Ng
The opioid system is activated in heart failure, which may be cardioprotective but may also be counter-regulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29152610/mutations-in-coagulation-factor-viii-are-associated-with-more-favorable-outcome-in-patients-with-cutaneous-melanoma
#8
Zheng Ping, Abha Soni, Lance A Williams, Huy P Pham, Malay K Basu, X Long Zheng
Coagulation factor VIII (FVIII), von Willebrand factor (VWF), and ADAMTS13 play an important role in regulation of normal hemostasis. However, little is known about their roles in patients with malignancy, particularly with cutaneous melanoma. Whole genome sequencing data are available for 25,719 cases in 126 cancer genomic studies for analysis. All sequencing data and corresponding pathology findings were obtained from The Cancer Genome Atlas. The cBioportal bioinformatics tools were used for the data analysis...
July 2017: TH Open
https://www.readbyqxmd.com/read/29142028/high-baseline-serum-clara-cell-16-kda-predicts-subsequent-lung-disease-worsening-in-systemic-sclerosis
#9
Sébastien Rivière, Thong Hua-Huy, Kiet Phong Tiev, Jean Cabane, Anh Tuan Dinh-Xuan
OBJECTIVE: Clara cell secretory protein (CC16) is a sensitive marker of bronchial epithelial cell damage. The CC16 serum level is elevated in patients with pulmonary fibrosis, but its predictive value on lung disease progression has not yet been studied. We aimed to assess the value of serum CC16 concentration in predicting lung disease deterioration in patients with systemic sclerosis (SSc). METHODS: We prospectively analyzed and followed 106 patients with SSc during a 4-year period for the risk of developing combined deleterious event, defined as a 10% decrease in total lung capacity or forced vital capacity from baseline, or death, according to serum CC16 at inclusion...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29137601/random-walks-on-mutual-microrna-target-gene-interaction-network-improve-the-prediction-of-disease-associated-micrornas
#10
Duc-Hau Le, Lieven Verbeke, Le Hoang Son, Dinh-Toi Chu, Van-Huy Pham
BACKGROUND: MicroRNAs (miRNAs) have been shown to play an important role in pathological initiation, progression and maintenance. Because identification in the laboratory of disease-related miRNAs is not straightforward, numerous network-based methods have been developed to predict novel miRNAs in silico. Homogeneous networks (in which every node is a miRNA) based on the targets shared between miRNAs have been widely used to predict their role in disease phenotypes. Although such homogeneous networks can predict potential disease-associated miRNAs, they do not consider the roles of the target genes of the miRNAs...
November 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29137006/definition-of-persistent-vomiting-in-current-medical-literature-a-systematic-review
#11
Mostafa Ebraheem Morra, Abdelrahman Elshafay, Aswin Ratna Kansakar, Ghaleb Muhammad Mehyar, Nguyen Phan Hoang Dang, Omar Mohamed Mattar, Somia Iqtadar, Mostafa Reda Mostafa, Vu Ngoc Hai, Tran Le-Huy Vu, Ahmed Abdelmotaleb Ghazy, Fatima Kaboub, Nguyen Tien Huy, Kenji Hirayama
BACKGROUND AND AIM: Persistent vomiting is mentioned as a symptom of a large variety of systemic disorders. It is commonly used interchangeably with chronic, recurrent, or intractable vomiting and widely used as a warning sign of severe illness in dengue infection. However, it has been poorly defined in the medical literature. Therefore, we aimed to systematically review a definition of persistent vomiting in the medical literature. METHODS: A systematic search was done through; PubMed, Google Scholar, Web of Science, Scopus, VHL, WHO-GHL, Grey Literature Report, POPLINE, and SIGLE for the last 10 years...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125024/wingspan-stent-delivery-catheter-fracture-and-the-trap-technique-for-endovascular-salvage
#12
Manoj Jagani, Huy M Do, Jeremy J Heit
Background Intracranial atherosclerotic disease may result in ischemic infarction and has a high rate of recurrent ischemic strokes despite medical therapy. Patients who fail medical therapy may undergo endovascular treatment with cerebral artery angioplasty and possible Wingspan stent placement. We present a unique case of Wingspan delivery microcatheter fracture that resulted in a retained foreign body and an endovascular salvage maneuver. Case description An elderly patient presented with an acute ischemic stroke due to a severe stenosis in the proximal left middle cerebral artery (MCA)...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29111001/the-professional-practice-and-training-of-neurology-in-the-asian-and-oceanian-region-a-cross-sectional-survey-by-the-asian-and-oceanian-association-of-neurology-aoan
#13
Artemio Roxas, Man Mohan Mehndiratta, Natan Bornstein, Richard Macdonell, Kheng Seang Lim, Ping-Wing Ng, Shuren Dashzeveg, Hidehiro Mizusawa, Hamed Esmatullah, Shey Lin Wu, Christopher Chen, Mohammad Kurniawan, Joung-Ho Rha, Mohammad Wasay, Niphon Poungvarin, Saman Gunatilake, Nguyen Huy Thang
OBJECTIVE: To survey AOAN member countries regarding their organizational structure, postgraduate neurology training program, and resources for neurological care provision. METHODOLOGY: A cross-sectional survey using a 36-item questionnaire was conducted among country representatives to AOAN from August 2015 to August 2016. RESULTS: A total of 18/20 AOAN member countries participated in the survey. All the countries have organized association with regular meetings, election of officers and neurology training program...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29101880/in-situ-observation-of-phase-transformation-in-iron-carbide-nanocrystals
#14
Le Thanh Cuong, Nguyen Duc Dung, Ta Quoc Tuan, Nguyen Thi Khoi, Pham Thanh Huy, Ngo Ngoc Ha
This paper reports on the in situ observation of phase transformation in an iron carbide nanocrystal encapsulated in a graphitic shell by means of high resolution transmission electron microscopy (HR-TEM). A Fe7C3 nanocrystal in orthorhombic (o-Fe7C3) structure with carbon graphitic cover is captured at the initial time of the experiment. Under the projection of a high-energy electron beam (200kV), the graphitic carbon layer evaporates gradually and structural changes in orthorhombic (o-Fe7C3) crystal manifests simultaneously...
October 31, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29089135/human-cancer-risk-estimation-for-1-3-butadiene-an-assessment-of-personal-exposure-and-different-microenvironments
#15
Lai Nguyen Huy, Shun Cheng Lee, Zhuozhi Zhang
This study estimated the lifetime cancer risk (LCR) attributable to 1,3-butadiene (BD) personal exposure and to other microenvironments, including residential home, outdoor, in-office, in-vehicle, and dining. Detailed life expectancy by country (WHO), inhalation rate and body weight by gender reported by USEPA were used for the calculation, focusing on adult population (25≤Age<65). LCR estimation of the adult population due to personal exposure exceeded the USEPA benchmark of 1×10(-6) in many cities. For outdoor BD exposure, LCR estimations in 45 out of 175 cities/sites (sharing 26%) exceeded the USEPA benchmark...
October 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29075946/antimicrobial-activity-and-stability-of-stapled-helices-of-polybia-mp1
#16
Huy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim
Polybia-MP1 is a well-known natural antimicrobial peptide isolated from the venom of the social wasp Polybia paulista. A recent study showed that this peptide displays a broad antibacterial spectrum as well as low toxicity to human red blood cells and normal fibroblasts. However, its moderate antimicrobial activity and high susceptibility to protease have been a major hurdle for clinical use. This study examined the possibility of developing biologically more potent, yet metabolically more stable, analogues of MP1 using an emerging technology termed "all-hydrocarbon stapling...
October 26, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29071747/the-management-of-anticoagulation-in-patients-undergoing-therapeutic-plasma-exchange-a-concise-review
#17
REVIEW
Sara M Shunkwiler, Huy P Pham, Geoffrey Wool, Tina S Ipe, Deanna C Fang, Elizabeth Biller, Angela Treml, John Weiss, Beverly W Baron, Mary Berg
We surveyed multiple apheresis centers represented by the authors for their clinical approach to the management of anticoagulation issues during therapeutic plasma exchange (TPE). We present the results of their practices and a review of the pertinent literature. As plasma is removed during TPE, replacement with all or partial non-plasma-containing fluids (eg, 5% albumin) may lead to significant changes in hemostasis. These changes are amplified in patients who are receiving anticoagulation. We discuss various anticoagulants as well as the monitoring and adjustment of anticoagulation before, during, and after TPE...
October 26, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29062811/activation-of-nf-kb-mediated-tnf-induced-antimicrobial-immunity-is-required-for-the-efficient-brucella-abortus-clearance-in-raw-264-7-cells
#18
Huynh T Hop, Alisha W B Reyes, Tran X N Huy, Lauren T Arayan, WonGi Min, Hu J Lee, Man H Rhee, Hong H Chang, Suk Kim
In this study, we explore the regulatory roles of pro-inflammatory cytokine tumor necrosis factor alpha (TNF) in the innate immunity of macrophages against B. abortus infection. We show that infection of macrophage with B. abortus induces marked expression and secretion of TNF which subsequently binds to TNF receptor 1 (TNFR-1) and activates a downstream signaling cascade of the innate immunity. Blocking of TNF signaling resulted in a notable increase of B. abortus survival which was associated with an increase of anti-inflammatory cytokine interleukin 10 (IL-10), a beneficial effector of Brucella survival, as well as remarkable decrease of reactive oxygen species (ROS) and nitric oxide (NO), antibrucella molecules...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29061506/panaxynol-a-natural-hsp90-inhibitor-effectively-targets-both-lung-cancer-stem-and-non-stem-cells
#19
Huong Thuy Le, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, Ho-Young Lee
Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Panaxynol inhibited the sphere forming ability of NSCLC CSCs at nanomolar concentrations, and micromolar concentrations of panaxynol suppressed the viability of NSCLC cells (non-CSCs) and their sublines carrying acquired chemoresistance with minimal effect on normal cells derived from various organs...
October 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29059809/early-prediction-of-future-hand-movements-using-semg-data
#20
Philipp Koch, Huy Phan, Marco Maass, Fabrice Katzberg, Alfred Mertins
We study in this work the feasibility of early prediction of hand movement based on sEMG signals to overcome the time delay issue of the conventional classification. Opposed to the classification task, the objective of early prediction is to predict a hand movement that is going to occur in the future given the information up to the current time point. The ability of early prediction may allow a hand prosthesis control system to compensate for the time delay and, as a result, improve the usability. Experimental results on the Ninapro database show that we can predict up to 300 ms ahead in the future while the prediction accuracy remains very close to that of the standard classification, i...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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