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https://www.readbyqxmd.com/read/28547390/mono-substitution-effects-on-antimicrobial-activity-of-stapled-heptapeptides
#1
Huy X Luong, Do-Hee Kim, Ngoan T Mai, Bong-Jin Lee, Young-Woo Kim
We previously reported a de novo design of antimicrobial heptapeptide helices using Verdine's all-hydrocarbon peptide stapling system. One of the important structure-activity relationships we found from these previous studies was that extending of the hydrophobic face by replacing of alanine with leucine in positon 5 increases antimicrobial activity. In this study, to further improve the activity profile of this peptide series, we investigated the substitution effects of position 5 on conformational and proteolytic stability as well as antimicrobial and hemolytic activity...
May 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28545406/deterministic-compressive-sampling-for-high-quality-image-reconstruction-of-ultrasound-tomography
#2
Tran Quang Huy, Huynh Huu Tue, Ton That Long, Tran Duc-Tan
BACKGROUND: A well-known diagnostic imaging modality, termed ultrasound tomography, was quickly developed for the detection of very small tumors whose sizes are smaller than the wavelength of the incident pressure wave without ionizing radiation, compared to the current gold-standard X-ray mammography. Based on inverse scattering technique, ultrasound tomography uses some material properties such as sound contrast or attenuation to detect small targets. The Distorted Born Iterative Method (DBIM) based on first-order Born approximation is an efficient diffraction tomography approach...
May 25, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28534272/braf-mutation-is-associated-with-an-improved-survival-in-glioma-a-systematic-review-and-meta-analysis
#3
REVIEW
Huy Gia Vuong, Ahmed M A Altibi, Uyen N P Duong, Hanh T T Ngo, Thong Quang Pham, Kar-Ming Fung, Lewis Hassell
Newly emerged molecular markers in gliomas provide prognostic values beyond the capabilities of histologic classification. BRAF mutation, especially BRAF V600E, is common in a subset of gliomas and may represent a potential prognostic marker. The aim of our study is to investigate the potential use of BRAF mutations on prognosis of glioma patients. Four electronic databases were searched for potential articles, including PubMed, Scopus, ISI Web of Science, and Virtual Health Library (VHL). Data of hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were directly obtained from original papers or indirectly estimated from Kaplan Meier curve (KMC)...
May 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28528485/lead-and-arsenic-accumulation-and-its-effects-on-plasma-cortisol-levels-in-oreochromis-sp
#4
Nguyen Quoc Thang, Bui The Huy, Le Van Tan, Nguyen Thi Kim Phuong
The accumulation, elimination and effect of heavy metals on plasma cortisol levels in Oreochromis sp. were studied in the exposure and recovery phases. In the exposure phase, the mean rate of accumulation in the tissues was in the order gill > liver > muscle for Pb exposure and muscle > liver > gill for As exposure. In the recovery phase, the order of elimination in the tissues was gill > liver > muscle for Pb and liver > gill > muscle for As. The amount of cortisol secreted by the Oreochromis sp...
May 20, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28525955/imaging-and-manipulating-energy-transfer-among-quantum-dots-at-individual-dot-resolution
#5
Duc A Nguyen, Huy A Nguyen, Joseph W Lyding, Martin Gruebele
Many processes of interest in quantum dots involve charge or energy transfer from one dot to another. Energy transfer in films of quantum dots as well as between linked quantum dots has been demonstrated by luminescence shift, and the ultrafast time-dependence of energy transfer processes has been resolved. Bandgap variation among dots (energy disorder) and dot separation are known to play an important role in how energy diffuses. Thus it would be very useful if energy transfer could be visualized directly on a dot-by-dot basis among small clusters or within films of quantum dots...
May 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28515226/a-neutralizing-anti-g-csfr-antibody-blocks-g-csf-induced-neutrophilia-without-inducing-neutropenia-in-nonhuman-primates
#6
Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews
Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil numbers and their recruitment to sites of inflammation is critical in maintaining a balanced immune response. In various inflammatory conditions, such as rheumatoid arthritis, vasculitis, cystic fibrosis, and inflammatory bowel disease, increased serum G-CSF correlates with neutrophilia and enhanced neutrophil infiltration into inflamed tissues. We describe a fully human therapeutic anti-G-CSFR antibody (CSL324) that is safe and well tolerated when administered via i...
May 17, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28510990/perioperative-nutrition-management-as-an-important-component-of-surgical-capacity-in-low-and-middle-income-countries
#7
REVIEW
Shinji Nakahara, Do Huy Nguyen, An Tho Bui, Michiko Sugiyama, Masao Ichikawa, Tetsuya Sakamoto, Teiji Nakamura
Needs for surgical care are growing in low- and middle-income countries. Existing surgical care capacity indicators, focusing on the availability of equipment, personnel, and operation and anaesthetic skills, are not intended to evaluate perioperative nutrition management, which influences surgical outcomes. In this narrative review, we describe the prevalence of malnutrition and its clinical consequences among surgical patients in low- and middle-income countries, suggest potential measures to improve nutrition management, and discuss the necessity of considering nutrition management as a component of surgical care capacity...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28507926/decrease-of-alpha-fetoprotein-in-patients-with-cirrhosis-treated-with-direct-acting-antivirals
#8
Kelvin Nguyen, Melissa Jimenez, Nima Moghadam, Crystal Wu, Alex Farid, Jonathan Grotts, David Elashoff, Gina Choi, Francisco A Durazo, Mohamed M El-Kabany, Steven-Huy B Han, Sammy Saab
Background and Aims: The lack of specificity has limited the role of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening among patients with cirrhosis related to hepatitis C virus (HCV) infection. We sought to examine whether AFP may decrease after achieving a sustained virological response (SVR) in patients with HCV-related cirrhosis. Methods: We performed a retrospective study of patients with HCV-related cirrhosis who were cured with direct-acting antiviral (DAA) therapy at the University of California, Los Angeles...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28505589/multi-platform-metabolomics-and-a-genetic-approach-support-the-authentication-of-agarwood-produced-by-aquilaria-crassna-and-aquilaria-malaccensis
#9
Huy Truong Nguyen, Jung-Eun Min, Nguyen Phuoc Long, Ma Chi Thanh, Thi Hong Van Le, Jeongmi Lee, Jeong Hill Park, Sung Won Kwon
Agarwood, the resinous heartwood produced by some Aquilaria species such as Aquilaria crassna, Aquilaria malaccensis and Aquilaria sinensis, has been traditionally and widely used in medicine, incenses and especially perfumes. However, up to now, the authentication of agarwood has been largely based on morphological characteristics, a method which is prone to errors and lacks reproducibility. Hence, in this study, we applied metabolomics and a genetic approach to the authentication of two common agarwood chips, those produced by Aquilaria crassna and Aquilaria malaccensis...
May 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28502880/maternal-care-modulates-the-febrile-response-to-lipopolysaccharide-through-differences-in-glucocorticoid-receptor-sensitivity-in-the-rat
#10
Carine Parent, Huy-Binh Nguyen, Xianglan Wen, Josie Diorio, Michael J Meaney, Tie Yuan Zhang
Early life adversity increases the risk for later infection. The febrile response is a potent mechanism to combat infection. We found that variations in maternal care influence the febrile response to 50 µg/kg lipopolysaccharide (LPS) challenge in adult male rats. Offspring from low-licking/grooming (LG) mothers had an increased febrile response compared to offspring from high-LG mothers challenged with LPS. Low-LG offspring had reduced plasma IL-6 at one and two hours post challenge compared to high-LG offspring...
May 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28501432/diverse-size-approach-to-incorporate-and-extend-highly-fluorescent-unnatural-nucleotides-into-dna
#11
Binh Huy Le, Ja Choon Koo, Han Na Joo, Young Jun Seo
We have prepared a series of size-diverse unnatural nucleotides containing fluorescent (dApyrTP, dUpyrTP, dUantTP, dUthiTP) and quencher (dUazoTP) units, as well as nucleotides presenting small functional groups (dAethTP, dAoctTP, dUethTP, dUiodTP), all based on deoxyadenosine and deoxyuridine, and examined their suitability for use in enzymatic incorporation and extension into DNA. We observed a size-dependence of the incorporation and extension capability (following the order dUiodTP=dUethTP=dUthiTP>dUazoTP>dUpyrTP>dUantTP) during primer extension...
March 23, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28500744/risk-of-cataract-among-interventional-cardiologists-and-catheterization-lab-staff-a-systematic-review-and-meta-analysis
#12
Ahmed Elmaraezy, Mostafa Ebraheem Morra, Abdelrhman Tarek Mohammed, Ahmed Al-Habaa, Ahmed Elgebaly, Ahmed Abdelmotaleb Ghazy, Adham M Khalil, Nguyen Tien Huy, Kenji Hirayama
OBJECTIVES: We performed a systematic review and meta-analysis to assess the risk of developing a radiation-induced cataract in interventional cardiologists (ICs). BACKGROUND: ICs are forced to radiation exposure during cardiac catheterization procedures. Since the eye lens is one of the most radiosensitive organs in the body, ICs are highly susceptible to develop a radiation-induced cataract. METHOD: We performed a systematic literature search of nine electronic databases to retrieve studies that report cataract among interventional cardiologists...
May 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28484952/the-anchoring-bias-reflects-rational-use-of-cognitive-resources
#13
REVIEW
Falk Lieder, Thomas L Griffiths, Quentin J M Huys, Noah D Goodman
Cognitive biases, such as the anchoring bias, pose a serious challenge to rational accounts of human cognition. We investigate whether rational theories can meet this challenge by taking into account the mind's bounded cognitive resources. We asked what reasoning under uncertainty would look like if people made rational use of their finite time and limited cognitive resources. To answer this question, we applied a mathematical theory of bounded rationality to the problem of numerical estimation. Our analysis led to a rational process model that can be interpreted in terms of anchoring-and-adjustment...
May 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28484951/empirical-evidence-for-resource-rational-anchoring-and-adjustment
#14
Falk Lieder, Thomas L Griffiths, Quentin J M Huys, Noah D Goodman
People's estimates of numerical quantities are systematically biased towards their initial guess. This anchoring bias is usually interpreted as sign of human irrationality, but it has recently been suggested that the anchoring bias instead results from people's rational use of their finite time and limited cognitive resources. If this were true, then adjustment should decrease with the relative cost of time. To test this hypothesis, we designed a new numerical estimation paradigm that controls people's knowledge and varies the cost of time and error independently while allowing people to invest as much or as little time and effort into refining their estimate as they wish...
May 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28472393/fluoroscopic-c-arm-and-ct-guided-selective-radiofrequency-ablation-for-trigeminal-and-glossopharyngeal-facial-pain-syndromes
#15
Nicholas A Telischak, Jeremy J Heit, Lucas W Campos, Omar A Choudhri, Huy M Do, Xiang Qian
Objectives.:  Percutaneous radiofrequency ablation (RFA) of the gasserian ganglion through the foramen ovale and the glossopharyngeal nerve at the jugular foramen is a classical approach to treating trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GPN), respectively. However, it can be technically challenging with serious complications. We have thus developed a novel technique utilizing C-arm and computerized tomography (CT) guidance to block TN and GPN. Our goals were to describe a three-dimensional image-based technique to improve patient comfort and to decrease procedural time associated with needle guidance...
May 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28471869/low-energy-virtual-monochromatic-dual-energy-computed-tomography-images-for-the-evaluation-of-head-and-neck-squamous-cell-carcinoma-a-study-of-tumor-visibility-compared-with-single-energy-computed-tomography-and-user-acceptance
#16
Reza Forghani, Hillary Kelly, Eugene Yu, Manon Belair, Laurent Létourneau-Guillon, Huy Le, Francesca Proulx, Thomas Ong, Xianming Tan, Hugh D Curtin, Mark Levental
OBJECTIVE: Dual-energy computed tomography (CT) 40-keV virtual monochromatic images (VMIs) have been reported to improve visualization of head and neck squamous cell carcinoma, but a direct comparison to single-energy CT (SECT) is lacking, and there is debate regarding subjective user preference. We compared 40-keV VMIs with SECT and performed a subjective evaluation of their utility and acceptability for clinical use. METHODS: A total of 60 dual-energy CT and 60 SECT scans from 2 different institutions were evaluated...
May 2, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28471682/aln-h-bn-heterostructures-for-mg-dopant-free-deep-ultraviolet-photonics
#17
David Arto Laleyan, Songrui Zhao, Steffi Y Woo, Hong Nhung Tran, Huy Binh Le, Thomas Szkopek, Hong Guo, Gianluigi A Botton, Zetian Mi
Aluminum-rich AlGaN is the ideal material system for emerging solid-state deep-ultraviolet (DUV) light sources. Devices operating in the near-UV spectral range have been realized; to date, however, the achievement of high-efficiency light-emitting diodes (LEDs) operating in the UV-C band (200-280 nm specifically) has been hindered by the extremely inefficient p-type conduction in AlGaN and the lack of DUV-transparent conductive electrodes. Here, we show that these critical challenges can be addressed by Mg dopant-free Al(Ga)N/h-BN nanowire heterostructures...
May 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28466303/a-new-and-efficient-approach-for-construction-of-uridine-uracil-auxotrophic-mutants-in-the-filamentous-fungus-aspergillus-oryzae-using-agrobacterium-tumefaciens-mediated-transformation
#18
Khuyen Thi Nguyen, Quynh Ngoc Ho, Loc Thi Binh Xuan Do, Linh Thi Dam Mai, Duc-Ngoc Pham, Huyen Thi Thanh Tran, Diep Hong Le, Huy Quang Nguyen, Van-Tuan Tran
Aspergillus oryzae is a filamentous fungus widely used in food industry and as a microbial cell factory for recombinant protein production. Due to the inherent resistance of A. oryzae to common antifungal compounds, genetic transformation of this mold usually requires auxotrophic mutants. In this study, we show that Agrobacterium tumefaciens-mediated transformation (ATMT) method is very efficient for deletion of the pyrG gene in different Aspergillus oryzae wild-type strains to generate uridine/uracil auxotrophic mutants...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28462916/subnanometre-resolution-structure-of-the-doublet-microtubule-reveals-new-classes-of-microtubule-associated-proteins
#19
Muneyoshi Ichikawa, Dinan Liu, Panagiotis L Kastritis, Kaustuv Basu, Tzu Chin Hsu, Shunkai Yang, Khanh Huy Bui
Cilia are ubiquitous, hair-like appendages found in eukaryotic cells that carry out functions of cell motility and sensory reception. Cilia contain an intriguing cytoskeletal structure, termed the axoneme that consists of nine doublet microtubules radially interlinked and longitudinally organized in multiple specific repeat units. Little is known, however, about how the axoneme allows cilia to be both actively bendable and sturdy or how it is assembled. To answer these questions, we used cryo-electron microscopy to structurally analyse several of the repeating units of the doublet at sub-nanometre resolution...
May 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28459689/color-orchestra-ordering-color-palettes-for-interpolation-and-prediction
#20
Huy Phan, Hongbo Fu, Antoni Chan
Color theme or color palette can deeply influence the quality and the feeling of a photograph or a graphical design. Although color palettes may come from different sources such as online crowd-sourcing, photographs and graphical designs, in this paper, we consider color palettes extracted from fine art collections, which we believe to be an abundant source of stylistic and unique color themes. We aim to capture color styles embedded in these collections by means of statistical models and to build practical applications upon these models...
April 25, 2017: IEEE Transactions on Visualization and Computer Graphics
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