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https://www.readbyqxmd.com/read/29156733/an-integrated-lncrna-microrna-and-mrna-signature-to-improve-prognosis-prediction-of-colorectal-cancer
#1
Yongfu Xiong, Rong Wang, Linglong Peng, Wenxian You, Jinlai Wei, Shouru Zhang, Xingye Wu, Jinbao Guo, Jun Xu, Zhenbing Lv, Zhongxue Fu
Although the outcome of patients with colorectal cancer (CRC) has improved significantly, prognosis evaluation still presents challenges due to the disease heterogeneity. Increasing evidences revealed the close correlation between aberrant expression of certain RNAs and the prognosis. We envisioned that combined multiple types of RNAs into a single classifier could improve postoperative risk classification and add prognostic value to the current stage system. Firstly, differentially expressed RNAs including mRNAs, miRNAs and lncRNAs were identified by two different algorithms...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29141604/genome-wide-identification-of-mirnas-and-lncrnas-in-cajanus-cajan
#2
Chandran Nithin, Amal Thomas, Jolly Basak, Ranjit Prasad Bahadur
BACKGROUND: Non-coding RNAs (ncRNAs) are important players in the post transcriptional regulation of gene expression (PTGR). On one hand, microRNAs (miRNAs) are an abundant class of small ncRNAs (~22nt long) that negatively regulate gene expression at the levels of messenger RNAs stability and translation inhibition, on the other hand, long ncRNAs (lncRNAs) are a large and diverse class of transcribed non-protein coding RNA molecules (> 200nt) that play both up-regulatory as well as down-regulatory roles at the transcriptional level...
November 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29138748/identifying-novel-glioma-associated-noncoding-rnas-by-their-expression-profiles
#3
Alenka Matjašič, Mojca Tajnik, Emanuela Boštjančič, Mara Popović, Boštjan Matos, Damjan Glavač
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play a significant role in cancer development as regulators of protein-coding genes. Their dysregulation was in some extent already associated with glioma, the most aggressive primary brain tumours in adults. The correct diagnosis and treatment selection due to high tumour heterogeneity might be difficult and inadequate, resulting in poor prognosis. Studies of expression patterns of noncoding RNAs (ncRNAs) could provide useful insight in glioma molecular development...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/29134827/serum-plasma-and-saliva-biomarkers-for-head-and-neck-cancer
#4
Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Matias Eliseo Melendez, André Lopes Carvalho
Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates have only improved marginally, mainly due to the advanced clinical stage at diagnosis and the high rates of treatment failure associated with this late diagnosis...
November 14, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29131440/mir-193b-availability-is-antagonized-by-lncrna-snhg7-for-faim2-induced-tumour-progression-in-non-small-cell-lung-cancer
#5
Kelin She, Hui Yan, Jun Huang, Huaping Zhou, Jianxing He
OBJECTIVES: Long non-coding RNAs have identified to involve into the tumour cell proliferation, apoptosis and metastasis. We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism. METHODS: Non-small cell lung cancer (NSCLC) and relative normal tissues (n = 25) were collected. The SNHG7 expression and function in NSCLC was determined. The SNHG7-miR 193b-FAIM2 network was analysed in vitro and vivo...
November 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29119055/mir-488-suppresses-cell-proliferation-and-invasion-by-targeting-adam9-and-lncrna-hulc-in-hepatocellular-carcinoma
#6
Dengdi Hu, Dan Shen, Min Zhang, Nengmeng Jiang, Feng Sun, Shibo Yuan, Kaiming Wan
MicroRNAs (miRNAs) have been identified as regulators of tumor proliferation, invasion, and metastasis in hepatocellular carcinoma (HCC). In the current study, we determined the clinical significance and biological role of miR-488 in HCC. Our results demonstrated that the expression of miR-488 was notably downregulated in HCC tissues compared with paired adjacent normal tissues. Lower miR-488 expression was positively associated with tumor size, vascular invasion, and shorter overall survival (OS) in HCC patients...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29110645/long-intergenic-non-protein-coding-rna-1567-linc01567-acts-as-a-sponge-against-microrna-93-in-regulating-the-proliferation-and-tumorigenesis-of-human-colon-cancer-stem-cells
#7
Xiaofeng Yu, Lin Mi, Jie Dong, Jian Zou
BACKGROUND: Cancer stem cells (CSCs) are considered to be the major factor in tumor initiation, progression, metastasis, recurrence and chemoresistance. Maintaining the stemness and promoting differentiation of these cells involve various factors. Recently, long non-coding RNAs (lncRNAs) have been identified as new regulatory factors in human cancer cells. However, the function of lncRNAs in colon CSCs is still unknown. METHODS: Primary colon cancer cells were maintained in serum-free medium to form spheres and CD133(+)/CD166(+)/CD44(+) spheroid cells were selected using FACS technique...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29107112/the-emerging-role-of-exosome-derived-non-coding-rnas-in-cancer-biology
#8
Qing Fan, Liang Yang, Xiaodong Zhang, Xueqiang Peng, Shibo Wei, Dongming Su, Zhenhua Zhai, Xiangdong Hua, Hangyu Li
Exosomes are a new means of intercellular information exchange that have aroused great research interest. Long neglected in research, exosomes were deemed nonfunctional cellular components to be discarded. However, it has been gradually revealed that exosomes are an important tool for the exchange of intercellular information and material. Exosomes contain specific repertoires of non-coding RNAs (ncRNAs, including microRNA and lncRNA), indicating that a specific RNA sorting mechanism may exist. Correspondingly, intracellular multivesicular bodies (MVBs) are produced after fusion with the cell membrane to release exosomes rather than inducing autophagy, which reveals that there may be a specific regulatory mechanism for MVB secretion...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29107050/microrna-21-and-long-non-coding-rna-malat1-are-overexpressed-markers-in-medullary-thyroid-carcinoma
#9
Ying-Hsia Chu, Heather Hardin, David F Schneider, Herbert Chen, Ricardo V Lloyd
BACKGROUND: Non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are well-recognized post-transcriptional regulators of gene expression. This study examines the expression of microRNA-21 (miR-21) and lncRNA MALAT1 in medullary thyroid carcinomas (MTCs) and their effects on tumor behavior. METHODS: Tissue microarrays (TMAs) were constructed using normal thyroid (n=39), primary tumors (N=39) and metastatic MTCs (N=18) from a total of 42 MTC cases diagnosed between 1987 and 2016...
October 26, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29104512/identification-and-analysis-of-p53-mediated-competing-endogenous-rna-network-in-human-hepatocellular-carcinoma
#10
Yiming Zhang, Ran Kang, Wenrong Liu, Yalan Yang, Ruofan Ding, Qingqing Huang, Junhua Meng, Lili Xiong, Zhiyun Guo
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous RNAs (ceRNAs) that compete to bind to shared microRNA (miRNA) recognition elements (MREs) to perform specific biological functions during tumorigenesis. The tumor suppressor p53 is a master regulator of cancer-related biological processes by acting as a transcription factor to regulate target genes including miRNA and lncRNA. However, the mechanism in human hepatocellular carcinoma and whether p53-mediated RNA targets could form ceRNA network remain unclear...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29095526/neat1-has-mir-98-5p-mapk6-axis-is-involved-in-non-small-cell-lung-cancer-nsclc-development
#11
Feima Wu, Qiang Mo, Xiaoling Wan, Jialong Dan, Haibo Hu
lncRNAs or microRNAs belong to the most two important non-coding RNAs and they are involved in a lot of cancers, including non-small cell lung cancer (NSCLC). Therefore, currently, we focused on the biological and clinical significance of lncRNA nuclear enriched abundant transcript 1 (NEAT1) and hsa-mir-98-5p in NSCLC. It was observed that NEAT1 was upregulated while hsa-mir-98-5p was downregulated respectively in NSCLC cell lines compared to human normal lung epithelial BES-2B cells. Inhibition of NEAT1 can suppress the progression of NSCLC cells and hsa-mir-98-5p can reverse this phenomenon...
November 2, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29091858/lncrna-gacat3-promotes-gastric-cancer-progression-by-negatively-regulating-mir-497-expression
#12
Li Feng, Yonggang Zhu, Yunxin Zhang, Min Rao
Accumulating evidence indicates that long noncoding RNAs (LncRNAs) are involved in tumorigenesis and tumor development. LncRNA GACAT3 (GACAT3) has been reported to be upregulated in gastric cancer (GC); however, the biological function and underlying mechanisms of GACAT3 remain largely unknown. Here, we found that GACAT3 showed a higher expression in GC tissues and cell lines. Increased GACAT3 level was significantly associated with a shorter overall survival of patients with GC. Functionally, we demonstrated that knockdown of GACAT3 significantly inhibited proliferation, colony formation, migration, and invasion of GC cells in vitro...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29075789/bancr-contributes-to-the-growth-and-invasion-of-melanoma-by-functioning-as-a-competing-endogenous-rna-to-upregulate-notch2-expression-by-sponging-mir%C3%A2-204
#13
Bingjie Cai, Yunpeng Zheng, Shanshan Ma, Qu Xing, Xinxin Wang, Bo Yang, Guangwen Yin, Fangxia Guan
BRAF-activated non-coding RNA (BANCR) is a long non-coding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including melanoma. However, the BANCR functions and downstream mechanisms are largely unknown. In this study, we aim to investigate how BANCR participates in the proliferation and migration of malignant melanoma and elucidate the underlying mechanism in this process. We found that the expression of the BANCR was low in melanocytic nevus and human melanocytes but high in melanoma tissues and cell lines...
October 23, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29074557/roles-of-micrornas-and-long-noncoding-rnas-in-the-progression-of-diabetic-retinopathy
#14
Qiaoyun Gong, Guanfang Su
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults across the world. The pathogenesis of DR is multifactorial, and the molecular mechanisms are still not fully understood. Accumulating evidence has demonstrated that noncoding RNAs may be aberrantly expressed and may play vital roles in the development of DR. Among noncoding RNAs, microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are known for their regulatory functions. Here, we summarize the functions and mechanisms of known aberrantly-expressed miRNAs and lncRNAs in DR...
October 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29073720/malat1-modulates-the-autophagy-of-retinoblastoma-cell-through-mir-124-mediated-stx17-regulation
#15
Jun Huang, Yuting Yang, Fang Fang, Ke Liu
The retinoblastoma is the most common intraocular malignant tumor in infants and children; it is one of the deadliest forms of cancer due to its limited sensitivity to chemotherapy and radiotherapy. In several cancers, chemoresistance is associated with autophagy induction. Non-coding RNAs, including long non-coding RNAs (lncRNA) and microRNAs (miRNAs) have been reported to regulate physiological activities of the cells, including proliferation, apoptosis, migration, as well as autophagy. MALAT1, a well-established lncRNA acts as an oncogene, promotes cancer proliferation and metastasis via the stimulation of autophagy...
October 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29072702/a-novel-lnc-pcf-promotes-the-proliferation-of-tgf-%C3%AE-1-activated-epithelial-cells-by-targeting-mir-344a-5p-to-regulate-map3k11-in-pulmonary-fibrosis
#16
Huizhu Liu, Bingsi Wang, Jinjin Zhang, Songzi Zhang, Youlei Wang, Jie Zhang, Changjun Lv, Xiaodong Song
Emerging evidence suggests that microRNA (miRNA) and long noncoding RNA (lncRNA) play important roles in disease development. However, the mechanism underlying mRNA interaction with miRNA and lncRNA in idiopathic pulmonary fibrosis (IPF) remains unknown. This study presents a novel lnc-PCF that promotes the proliferation of TGF-β1-activated epithelial cells through the regulation of map3k11 by directly targeting miR-344a-5p during pulmonary fibrogenesis. Bioinformatics and in vitro translation assay were performed to confirm whether or not lnc-PCF is an actual lncRNA...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29053187/xist-promotes-gastric-cancer-gc-progression-through-tgf-%C3%AE-1-via-targeting-mir-185
#17
Quan Zhang, Baiyu Chen, Ping Liu, Jing Yang
LncRNAs and microRNAs can play significant roles in various cancers, including gastric cancer (GC). In our study, we investigated the role of lncRNA XIST in GC. We observed that XIST was increased in MGC803 and BGC823 cells compared to human normal gastric epithelial GES-1 cells. It was also shown that miR-185 was decreased in GC cell lines. Silencing XIST can inhibit the growth of GC cells and bioinformatics analysis was performed to confirm the correlation between XIST and miR-185. Interestingly, a negative correlation was indicated between XIST and miR-185 in GC cells...
October 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29044429/dynamic-expression-of-long-noncoding-rnas-reveals-their-potential-roles-in-spermatogenesis-and-fertility
#18
Lauren Wichman, Saigopal Somasundaram, Christine Breindel, Dana M Valerio, John R McCarrey, Craig A Hodges, Ahmad M Khalil
Mammalian reproduction requires that males and females produce functional haploid germ cells through complex cellular differentiation processes known as spermatogenesis and oogenesis, respectively. While numerous studies have functionally characterized protein-coding genes and small noncoding RNAs (microRNAs and piRNAs) that are essential for gametogenesis, the roles of regulatory long noncoding RNAs (lncRNAs) are yet to be fully characterized. Previously, we and others have demonstrated that intergenic regions of the mammalian genome encode thousands of long noncoding RNAs, and many studies have now demonstrated their critical roles in key biological processes...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29039813/transcriptomic-analysis-of-long-non-coding-rnas-and-coding-genes-uncovers-a-complex-regulatory-network-that-is-involved-in-maize-seed-development
#19
Ming Zhu, Min Zhang, Lijuan Xing, Wenzong Li, Haiyang Jiang, Lei Wang, Miaoyun Xu
Long non-coding RNAs (lncRNAs) have been reported to be involved in the development of maize plant. However, few focused on seed development of maize. Here, we identified 753 lncRNA candidates in maize genome from six seed samples. Similar to the mRNAs, lncRNAs showed tissue developmental stage specific and differential expression, indicating their putative role in seed development. Increasing evidence shows that crosstalk among RNAs mediated by shared microRNAs (miRNAs) represents a novel layer of gene regulation, which plays important roles in plant development...
October 17, 2017: Genes
https://www.readbyqxmd.com/read/29039552/prospective-lncrna-mirna-mrna-regulatory-network-of-long-non-coding-rna-linc00968-in-non-small-cell-lung-cancer-a549-cells-a-mirna-microarray-and-bioinformatics-investigation
#20
Dong-Yao Li, Wen-Jie Chen, Lei Luo, Yong-Kun Wang, Jun Shang, Yu Zhang, Gang Chen, Shi-Kang Li
Accumulating evidence suggests that the dysregulation of long non-coding RNAs (lncRNAs) serves vital roles in the incidence and progression of lung cancer. However, the molecular mechanisms of LINC00968, a recently identified lncRNA, remain unknown. The objective of present study was to investigate the role of a prospective lncRNA-miRNA‑mRNA network regulated by LINC00968 in non-small cell lung cancer cells. Following the transfection of lentiviruses carrying LINC00968 into A549 cells, the microRNA (miRNA) expression profile of the cells in response to the overexpression of LINC00968 was detected using an miRNA microarray...
October 12, 2017: International Journal of Molecular Medicine
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