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https://www.readbyqxmd.com/read/29328401/long-non-coding-rna-meg3-functions-as-a-tumour-suppressor-and-has-prognostic-predictive-value-in-human-pancreatic-cancer
#1
Ling Ma, Feng Wang, Chong Du, Zhengkui Zhang, Huahu Guo, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Xiaodong Tian, Yinmo Yang
Long non-coding RNA (lncRNA) MEG3 has been demonstrated to be a tumour suppressor in many malignancies. However, the functional role of MEG3 in pancreatic cancer (PC) is unclear. In this study, the expression pattern of MEG3 was evaluated in 25 samples of microdissected PC tissues and 8 PC cell lines and was compared to the expression in adjacent non‑cancerous tissues and a human pancreatic normal epithelial cell line. Loss of MEG3 expression was observed in both the cancerous tissues and cancer cell lines...
January 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29298720/ccat2-is-an-oncogenic-long-non-coding-rna-in-pancreatic-ductal-adenocarcinoma
#2
Yi Cai, Xiaomei Li, Peng Shen, Dong Zhang
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with poor prognosis. Long non-coding RNAs (lncRNAs), a group of non-coding RNAs, play important roles in the progression of PDAC. This study aimed to investigate the potential involvement of lncRNA CCAT2 in PDAC tumorigenesis. METHODS: Expression of CCAT2 was detected by quantitative real-time PCR (qRT-PCR) in 80 human PDAC tissues and three PDAC cell lines. The effects of CCAT2 silencing in PANC-1 cells on cell proliferation and invasion were studied using MTT assay and transwell assay, respectively...
January 3, 2018: Biological Research
https://www.readbyqxmd.com/read/29290766/integrated-analysis-of-long-non-coding-rna-and-mrna-expression-profile-in-pancreatic-cancer-derived-exosomes-treated-dendritic-cells-by-microarray-analysis
#3
Jionghuang Chen, Shaowen Wang, Shengnan Jia, Guoping Ding, Guixing Jiang, Liping Cao
Background: Pancreatic cancer is a devastating disease with a low five-year survival rate. Dendritic cells (DCs), which are the most potent antigen-presenting cells in the human body, play a pivotal role in the immune response. However, few studies have investigated the role of pancreatic cancer-derived exosomes (PEXs) in DC-meditated immune escape. The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. Methods: We used integrated lncRNA and mRNA microarrays to determine the expression profiles of PEX-treated DCs and normal DCs derived from five healthy donors...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29286182/knockdown-of-pseudogene-derived-from-lncrna-duxap10-inhibits-cell-proliferation-migration-invasion-and-promotes-apoptosis-in-pancreatic-cancer
#4
Yifan Lian, Chuanxing Xiao, Changsheng Yan, Dajun Chen, Qingwen Huang, Yanyun Fan, Zhaohua Li, Hongzhi Xu
Current evidence suggests that pseudogene derived lncRNAs may be important players in human cancer progression. Our previous study showed that DUXAP10 could promote cell proliferation in colorectal cancer. However, the clinical significance and potential role of DUXAP10 in human pancreatic cancer (PC) has not been uncovered. In this study, we found that DUXAP10 was overexpressed in PC tissues compared with normal tissues. DUXAP10 expression was significantly higher in patients with an advanced TNM stage and positive lymph node metastasis...
December 29, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239017/five-key-lncrnas-considered-as-prognostic-targets-for-predicting-pancreatic-ductal-adenocarcinoma
#5
Jukun Song, Qiuyan Yan, Haodeng Zhang, Xinhai Yin, Chen Zhu, Ke Zhao, Jianguo Zhu
To improve PDCA prognosis, a screening biomarker for early diagnosis of pancreatic cancer is in urgent need. Long non-coding RNA (lncRNA) expression profiles as potential cancer prognostic biomarkers play critical roles in development of tumorigenesis and metastasis of cancer. However, lncRNA signatures in predicting the survival of a patient with PDAC remain unknown. In the current study, we try to identify potential lncRNA biomarkers and their prognostic values in PDAC. LncRNAs expression profiles and corresponding clinical information for 182 cases with PDAC were acquired from The Cancer Genome Atlas (TCGA)...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29232661/downregulation-of-long-noncoding-rna-gas5-affects-cell-cycle-and-insulin-secretion-in-mouse-pancreatic-%C3%AE-cells
#6
Feiyan Jin, Ning Wang, Yanan Zhu, Lianghui You, Lintao Wang, Wei De, Wei Tang
BACKGROUND: Evidence shows that long non-coding RNAs (lncRNAs) are involved in individual development, cell differentiation, cell cycle processes and other important life processes and are closely related to major human diseases, including diabetes. Recent studies have reported that lncRNAs are involved in β cell functions and that lncRNA Gas5 levels decreased in T2DM patients' serum. The purpose of this study was to clarify the role of lncRNA Gas5 in mouse β cell functions in vitro and in vivo...
October 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29228419/expression-and-clinical-significance-of-long-non-coding-rna-ghet1-in-pancreatic-cancer
#7
H-Y Zhou, H Zhu, X-Y Wu, X-D Chen, Z-G Qiao, X Ling, X-M Yao, J-H Tang
OBJECTIVE: To investigate the expression level and biological function of long non-coding RNA gastric carcinoma high expressed transcript 1 (lncRNA-GHET1) in pancreatic ductal adenocarcinoma (pancreatic cancer for short), to analyze the correlation between the expression of GHET1 and clinicopathological features and to explore the role and clinical significance of GHET1 in the development and progression of pancreatic cancer. PATIENTS AND METHODS: The relative expression of GHET1 in 5 human pancreatic cancer cell lines was detected by quantitative Real-time polymerase chain reaction (qRT-PCR)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29225772/long-non-coding-rna-gas5-suppresses-pancreatic-cancer-metastasis-through-modulating-mir-32-5p-pten-axis
#8
Zhi-Qiang Gao, Jun-Feng Wang, De-Hua Chen, Xue-Song Ma, Yang Wu, Zhe Tang, Xiao-Wei Dang
Background: Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) progression is currently unknown, so the aim of this study was to explore the functional participation of GAS5 in PC metastasis. Methods: The expression changes of GAS5, miR-32-5p and PTEN in human PC specimens and cell lines were compared by means of molecular biology methods...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29221115/lncrna-malat1-hottip-and-pvt1-as-predictors-for-predicting-the-efficacy-of-gem-based-chemotherapy-in-first-line-treatment-of-pancreatic-cancer-patients
#9
Cui-Juan Wang, Sheng-Bin Shi, Jing Tian, Jun Xu, Zuo-Xing Niu
This study evaluated the lnc-RNAs as biomarker to predict efficacy of gemcitabine (GEM) based chemotherapy as the first-line treatment for locally advanced or advanced pancreatic cancer patients. We selected 62 patients with GEM based chemotherapy and divided two groups according to the PFS. We found that the expression of MALAT1, HOTTIP, and PVT1 in serum had a significant difference among the two groups. Furthermore, we estimated the PFS and response rate based on the expression levels of MALAT1, HOTTIP and PVT1...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215734/study-on-mechanism-about-long-noncoding-rna-malat1-affecting-pancreatic-cancer-by-regulating-hippo-yap-signaling
#10
Yongping Zhou, Ting Shan, Wenzhou Ding, Zhiyuan Hua, Yijun Shen, Zhihua Lu, Bo Chen, Tu Dai
OBJECTIVE: By investigating the migration and invasion ability in pancreatic cancer, this study probed into the lncRNA MALAT1 molecular mechanism on Hippo-YAP signaling. METHODS: The expression of lncRNA MALAT1 in PC tissues and cells was detected by qRT-PCR and western blot. The effect of si-MALAT1 on proliferation was determined by CCK-8 assay. Cell apoptosis, migration and invasion were respectively detected by flow cytometry assay, wound healing assay and transwell assay...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29212244/identification-of-potential-prognostic-cerna-module-biomarkers-in-patients-with-pancreatic-adenocarcinoma
#11
Lili Zhao, Bingrong Liu
Accumulating evidence suggested that long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to interact with other RNA transcripts and ceRNAs perturbation play important roles in cancer initiation and progression including pancreatic adenocarcinoma (PAAD). In this study, we constructed a PAAD-specific hallmark gene-related ceRNA network (HceNet) using paired genome-wide expression profiles of mRNA, lncRNA and miRNA and regulatory relationships between them. Based on "ceRNA hypothesis", we analyzed the characteristics of HceNet and identified a ceRNA module comprising of 29 genes (12 lncRNAs, two miRNAs and 15 mRNAs) as potential prognostic biomarkers related to overall survival of patients with PAAD...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207609/reciprocal-regulation-of-dgcr5-and-mir-320a-affects-the-cellular-malignant-phenotype-and-5-fu-response-in-pancreatic-ductal-adenocarcinoma
#12
Sun Yong, Yu Yabin, Zhou Bing, Zhu Chuanrong, Gu Dianhua, Zhang Jianhuai, Yuan Weidong, Wang Shuming, Liu Ling
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies. Long non-coding microRNAs (lncRNAs) are a newly discovered type of regulatory molecule with both diagnostic and prognostic value, but the role of lncRNA in PDAC has not been well investigated until now. Here, we present evidence that shows that the lncRNA DGCR5 is significantly reduced in PDAC tissues as well as in PDAC cell lines and that the downregulation of DGCR5 predicts poor prognosis. Ectopic expression of DGCR5 inhibits the proliferation and migration, and promotes 5-FU resistances of PDAC cells...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29201179/gemcitabine-treatment-causes-resistance-and-malignancy-of-pancreatic-cancer-stem-like-cells-via-induction-of-lncrna-hotair
#13
Li Wang, Ping Dong, Weiguo Wang, Mingquan Huang, Bole Tian
Gemcitabine is the first-line chemotherapeutic agent for advanced adenocarcinoma of the pancreas, despite the high risk of chemoresistance as a major disadvantage. In the past few years, significant advances have been made in the field of pancreatic cancer stem-like cells (CSCs) and their critical roles in drug resistance, invasion and metastasis, which are tightly regulated by long non-coding RNAs (lncRNAs). The present study demonstrated that HOX antisense intergenic RNA (HOTAIR) is not different between the pancreatic cancer cell line PANC-1 and its enriched CSC sub-population...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29179507/meta-analysis-of-the-clinical-value-of-abnormally-expressed-long-non-coding-rnas-for-pancreatic-cancer
#14
Liangliang Lei, Jianguang Wang, Like Zhang, Yanbin Chen, Pengfei Yuan, Dechun Liu
Pancreatic cancer (PC) is one of the most lethal malignant neoplasms of the digestive system. Long non-coding RNAs (lncRNAs) are a novel type of non-protein coding transcripts that play an important role in pancreatic carcinogenesis. We herein aimed to meta-analyze the diagnostic and prognostic significance of lncRNA expression profiles in PC. A comprehensive retrieval of eligible studies was performed based on the online databases. Quantitative meta-analyses of the pooled diagnostic parameters and hazard ratios (HRs) were enabled by using standard statistical methods...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147491/augmented-expression-levels-of-lncrnas-eccebpa-and-uca1-in-gastric-cancer-tissues-and-their-clinical-significance
#15
Mojdeh Nasrollahzadeh-Khakiani, Modjtaba Emadi-Baygi, Parvaneh Nikpour
Objectives: As the second cause of cancer death, gastric cancer (GC) is one of the eminent dilemmas all over the world, therefore investigating the molecular mechanisms involved in this cancer is pivotal. Unrestricted proliferation is one of the characteristics of cancerous cells, which is due to deficiency in cell regulatory systems. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of the epigenome. lncRNA extra coding CEBPA (ecCEBPA) is involved in DNA methylation...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29137412/long-non-coding-rna-snhg15-inhibits-p15-and-klf2-expression-to-promote-pancreatic-cancer-proliferation-through-ezh2-mediated-h3k27me3
#16
Zhonghua Ma, Hesuyuan Huang, Jirong Wang, Yan Zhou, Fuxing Pu, Qinghong Zhao, Peng Peng, Bingqing Hui, Hao Ji, Keming Wang
Long non-coding RNA (lncRNA) is emerging as an critical regulator in multiple cancers, including pancreatic cancer (PC). Recently, lncRNA SNHG15 was found to be up-regulated in gastric cancer and hepatocellular carcinoma, exerting oncogenic effects. Nevertheless, the biological function and regulatory mechanism of SNHG15 remain unclear in pancreatic cancer (PC). In this study, we reported that SNHG15 expression was also upregulated in PC tissues, and its overexpression was remarkably associated with tumor size, tumor node metastasis (TNM) stage and lymph node metastasis in patients with PC...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132136/meg3-suppresses-human-pancreatic-neuroendocrine-tumor-cells-growth-and-metastasis-by-down-regulation-of-mir-183
#17
Yuan-Yuan Zhang, Hao-Miao Feng
BACKGROUND/AIMS: Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms which arise from pancreatic islet cells. Recently, lncRNA MEG3 has been reported as a tumor suppressor in variety cancers. This study aimed to reveal the functional effects of MEG3 on pNETs which has not been uncovered previously. METHODS: The expression of MEG3, miR-183, and BRI3 in BON1 cells were altered by transfection with their specific vectors/shRNA, or mimic/inhibitor. Thereafter, cell viability, apoptosis, the protein expressions of cell cycle related factors, and apoptosis associated factors, as well as cell migration and invasion were respectively assessed by typan blue staining, flow cytometry, western blotting, and transwell assay...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29121972/long-noncoding-rna-norad-a-novel-competing-endogenous-rna-enhances-the-hypoxia-induced-epithelial-mesenchymal-transition-to-promote-metastasis-in-pancreatic-cancer
#18
Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
BACKGROUND: Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion and metastasis. Recent evidence indicates that the long noncoding RNA NORAD may be a potential oncogenic gene and that this lncRNA is significantly upregulated during hypoxia. However, the overall biological role and clinical significance of NORAD remains largely unknown...
November 9, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29118556/long-non-coding-rna-in-pancreatic-adenocarcinoma-and-pancreatic-neuroendocrine-tumors
#19
REVIEW
Dimitrios Moschovis, Maria Gazouli, Maria Tzouvala, Antonios Vezakis, George Karamanolis
Interest in non-coding regions of DNA has been increasing since the mapping of the human genome revealed that human DNA contains far fewer genes encoding proteins than previously expected. However, analysis of the derivatives of DNA transcription (transcriptomics) revealed that the majority of the genetic material is transcribed into non-coding RNA (ncRNA), indicating that these molecules probably provide the functional diversity and complexity of the physiology of the human body that cannot be attributed to the proteins...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29112934/long-non-coding-rna-gas5-antagonizes-the-chemoresistance-of-pancreatic-cancer-cells-through-down-regulation-of-mir-181c-5p
#20
Zhi-Qiang Gao, Jun-Feng Wang, De-Hua Chen, Xue-Song Ma, Wu Yang, Tang Zhe, Xiao-Wei Dang
OBJECTIVE: To explore the core mechanism of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in the regulation of multidrug resistance of pancreatic cancer cells. METHODS: mRNA levels of GAS5, miR-181c-5p and Hippo pathway related genes were detected by quantitative real-time PCR (qRT-PCR). Protein levels of MDR-1, MST1, YAP and TAZ were measured by western blot. Cell viability was detected by MTT assay. The combination between GAS5 and miR-181c-5p was confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assay...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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