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lncRNA pancreatic

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https://www.readbyqxmd.com/read/28320094/lncrna-meg3-had-anti-cancer-effects-to-suppress-pancreatic-cancer-activity
#1
Lei Gu, Jiaqiang Zhang, Minmin Shi, Qian Zhan, Baiyong Shen, Chenghong Peng
AIM: The aim of this study was to explain the mechanism of lncRNA MEG 3 in pancreatic cancer. METHODS: We were collecting 30 pancreatic cancer patients, taking the sample from these patients. We measured the PI3K protein expressions from 30 patients by IHC and WB methods and MEG 3 expression by RT-PCR, and analyzed the relationship between PI3K protein expression and pancreatic cancer patients' clinical pathology and the correlation between lncRNA MEG 3 and PI3K...
March 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28315290/uca1-regulates-the-growth-and-metastasis-of-pancreatic-cancer-by-sponging-mir-135a
#2
Xiaobo Zhang, Feng Gao, Lei Zhou, Huaitao Wang, Gang Shi, Xiaodong Tan
Pancreatic cancer (PC) is a devastating malignant disease with poor prognosis. This study is aimed to investigate the role of urothelial carcinoma associated 1(UCA1) in the progression of PC. Our results revealed that long non-coding RNAs (lncRNAs)-UCA1 was overexpressed in PC tissues compared with adjacent histologically normal tissues. Down-regulated level of UCA1 was also detected in five human pancreatic cancer cell lines (SW1990,BxPC-3, MiaPaCa-2, PANC-1, CAPAN-1) compared with normal pancreatic duct epithelial HPDE cells...
March 7, 2017: Oncology Research
https://www.readbyqxmd.com/read/28295543/lncrna-xist-promotes-pancreatic-cancer-proliferation-through-mir-133a-egfr
#3
Wei Wei, Yu Liu, Yebin Lu, Bo Yang, Ling Tang
According to recent studies, long non-coding RNA X-inactive specific transcript (XIST) is involved in the development and progression of many malignant tumors including pancreatic cancer. We validated the detailed role of XIST in human pancreatic cancer (PC) cell lines and PC tissues so as to determine its exact function and the mechanism by which it affected PC proliferation. In our research, lncRNA-XIST was specifically upregulated in PC tissues and cell lines, and high XIST expression in PC was related to poorer prognosis (larger tumor size, perineural invasion, lymph node micrometastases and shorter overall survival)...
March 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28220683/analysis-of-distinct-long-noncoding-rna-transcriptional-fingerprints-in-pancreatic-ductal-adenocarcinoma
#4
Xiang Yu, Yang Lin, Wu Sui, Yanfen Zou, Zhongchuan Lv
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies with the worst prognosis. Recent studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in tumorigenesis and cancer progression. However, the expression pattern and roles of lncRNAs in the development of PDAC remain unknown. Herein, we globally analyzed the lncRNA expression profile in human PDAC and non-tumor tissues using four independent public microarray datasets from Gene Expression Omnibus (GEO)...
March 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28202235/stx12-lncrna-mir-148a-smad5-participate-in-the-regulation-of-pancreatic-stellate-cell-activation-through-a-mechanism-involving-competing-endogenous-rna
#5
Hao Wang, Yanfeng Jiang, Ming Lu, Bei Sun, Xin Qiao, Dongbo Xue, Weihui Zhang
BACKGROUND: With the deepening of research, the roles of LncRNAs play in the fibrotic process have attracted great attention. At the early stage of pancreatic fibrogenesis, to effectively regulate pancreatic stellate cells (PSCs) activation is crucial for the treatment of chronic pancreatic fibrosis. METHODS: Microarray data on chronic pancreatitis were retrieved from the Gene Expression Omnibus (GEO) repository and analyzed using bioinformatic methods. A diagram of the lncRNA-miRNA-mRNA ceRNA network was constructed...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28163033/long-noncoding-rna-activated-by-tgf-%C3%AE-in-human-cancers-a-meta-analysis
#6
REVIEW
Yang-Hua Fan, Chen-Xing Ji, Bing Xu, Heng-Yi Fan, Zu-Jue Cheng, Xin-Gen Zhu
BACKGROUND: Because long non-coding RNA ATB (activated by TGF-β) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. METHODS: We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until November 15, 2016 and identified eight studies with 818 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between lncRNA-ATB expression and overall survival (OS), recurrence -free survival (RFS), disease-free survival (DFS)...
February 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28118609/the-clinical-value-of-lncrna-neat1-in-digestive-system-malignancies-a-comprehensive-investigation-based-on-57-microarray-and-rna-seq-datasets
#7
Dan-Dan Xiong, Zhen-Bo Feng, Wei-Luan Cen, Jing-Jing Zeng, Lu Liang, Rui-Xue Tang, Xiao-Ning Gan, Hai-Wei Liang, Zu-Yun Li, Gang Chen, Dian-Zhong Luo
This comprehensive investigation was performed to evaluate the expression level and potential clinical value of NEAT1 in digestive system malignancies. A total of 57 lncRNA datasets of microarray or RNA-seq and 5 publications were included. The pooled standard mean deviation (SMD) indicated that NEAT1 was down-regulated in esophageal carcinoma (ESCA, SMD = -0.35, 95% CI: -0.5~-0.20, P < 0.0001) and hepatocellular carcinoma (HCC, SMD = -0.47, 95% CI: -0.60~-0.34, P < 0.0001), while in pancreatic cancer (PC), NEAT1 was up-regulated (SMD = 0...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28042953/cervical-small-cell-neuroendocrine-tumor-mutation-profiles-via-whole-exome-sequencing
#8
Soo Young Cho, Minhye Choi, Hyo-Jeong Ban, Chang Hyeon Lee, Soojun Park, HanKyeom Kim, Young-Sik Kim, Young Seek Lee, Ji-Yun Lee
Cervical small cell neuroendocrine tumors (CSCNETs) are rare, aggressive neuroendocrine tumors (NETs). Reliable diagnostic and prognostic CSCNET markers are lacking, making diagnosis and prognosis prediction difficult, and treatment strategies limited. Here we provide mutation profiles for five tumor-normal paired CSCNETs using whole exome sequencing (WES). We expanded our assessment of frequently mutated genes to include publicly available data from 55 small intestine neuroendocrine tumors, 10 pancreatic neuroendocrine tumors, 42 small cell lung cancers, six NET cell lines, and 188 cervical cancers, along with our five CSCNETs...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28041957/human-pancreatic-%C3%AE-cell-lncrnas-control-cell-specific-regulatory-networks
#9
Ildem Akerman, Zhidong Tu, Anthony Beucher, Delphine M Y Rolando, Claire Sauty-Colace, Marion Benazra, Nikolina Nakic, Jialiang Yang, Huan Wang, Lorenzo Pasquali, Ignasi Moran, Javier Garcia-Hurtado, Natalia Castro, Roser Gonzalez-Franco, Andrew F Stewart, Caroline Bonner, Lorenzo Piemonti, Thierry Berney, Leif Groop, Julie Kerr-Conte, Francois Pattou, Carmen Argmann, Eric Schadt, Philippe Ravassard, Jorge Ferrer
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis...
February 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28034748/mir-216a-decreases-malat1-expression-induces-g2-m-arrest-and-apoptosis-in-pancreatic-cancer-cells
#10
Yajing Zhang, Xiaomei Tang, Minmin Shi, Chenlei Wen, Baiyong Shen
How lncRNA MALAT1 is regulated by miRNAs at posttranscriptional level in pancreatic cancer and their regulative effects on the cancer cells remain largely unknown. By retrieving previous miRNA array data and performing primary qRT-PCR, we observed a significant negative correlation between miR-216a and MALAT1 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues. The following in vitro cell assay further confirmed a direct binding between miR-216a and MALAT1 and the suppressive effect of miR-216a on MALAT1 expression...
February 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27992375/improved-method-for-prioritization-of-disease-associated-lncrnas-based-on-cerna-theory-and-functional-genomics-data
#11
Peng Wang, Qiuyan Guo, Yue Gao, Hui Zhi, Yan Zhang, Yue Liu, Jizhou Zhang, Ming Yue, Maoni Guo, Shangwei Ning, Guangmei Zhang, Xia Li
Although several computational models that predict disease-associated lncRNAs (long non-coding RNAs) exist, only a limited number of disease-associated lncRNAs are known. In this study, we mapped lncRNAs to their functional genomics context using competing endogenous RNAs (ceRNAs) theory. Based on the criteria that similar lncRNAs are likely involved in similar diseases, we proposed a disease lncRNA prioritization method, DisLncPri, to identify novel disease-lncRNA associations. Using a leave-one-out cross validation (LOOCV) strategy, DisLncPri achieved reliable area under curve (AUC) values of 0...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925173/potential-of-long-non-coding-rnas-in-cancer-patients-from-biomarkers-to-therapeutic-targets
#12
REVIEW
Subash Chandra Gupta, Yashoda Nandan Tripathi
Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a biomarker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer and many other cancer types. Some lncRNAs have also been used as adjunct to improve the specificity and sensitivity of existing biomarkers. The molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE and quantitative real-time PCR have been used for examining the lncRNAs' potential...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27888106/long-non-coding-rna-neat1-facilitates-pancreatic-cancer-progression-through-negative-modulation-of-mir-506-3p
#13
Bo Huang, Chuan Liu, Qiong Wu, Jing Zhang, Qinghua Min, Tianle Sheng, Xiaozhong Wang, Yeqing Zou
Recently, long non-coding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumourigenesis. Increasing evidence has suggested that lncRNA NEAT1 has been implicated in various types of human cancer. However, the potential biological roles and regulatory mechanisms of NEAT1 in pancreatic cancer (PC) remains unclear. Here, we found that the expression level of NEAT1 was higher in PC tissues compared to the corresponding non-tumor tissues. Besides, our findings indicate that high NEAT1 expression level is closely correlated with tumor progression and poor survival in PC patients...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27708234/plasma-and-tumor-levels-of-linc-pint-are-diagnostic-and-prognostic-biomarkers-for-pancreatic-cancer
#14
Le Li, Guang-Quan Zhang, Hua Chen, Zhong-Jie Zhao, Hong-Ze Chen, Huan Liu, Gang Wang, Yue-Hui Jia, Shang-Ha Pan, Rui Kong, Yong-Wei Wang, Bei Sun
Long intergenic non-protein coding RNA, p53 induced transcript (Linc-pint) is a long noncoding RNA (lncRNA) that regulates tumor cell viability and proliferation. We used qRT-PCR and RNA FISH analysis to evaluate Linc-pint levels in the plasma and tumor tissues of pancreatic cancer (PCa) patients. Our data demonstrate that Linc-pint expression is lower in plasma samples from PCa patients than from healthy individuals, and indicate that plasma Linc-pint levels are more sensitive than CA19-9 for detecting PCa...
November 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27698546/insights-from-lncrnas-profiling-of-min6-beta-cells-undergoing-inflammation
#15
Chuntao Sun, Lihua Xue, Ziyang Zhu, Fan Zhang, Ruixue Yang, Xuewen Yuan, Zhanjun Jia, Qianqi Liu
Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by chronic and progressive apoptotic destruction of pancreatic beta cells. During the initial phases of T1DM, cytokines and other inflammatory mediators released by immune cells progressively infiltrate islet cells, induce alterations in gene expression, provoke functional impairment, and ultimately lead to apoptosis. Long noncoding RNAs (lncRNAs) are a new important class of pervasive genes that have a variety of biological functions and play key roles in many diseases...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27689400/long-noncoding-rna-uc-345-promotes-tumorigenesis-of-pancreatic-cancer-by-upregulation-of-hnrnpl-expression
#16
Chao Liu, Jiamin Wang, Xiaoyuan Yuan, Wenli Qian, Bosen Zhang, Minmin Shi, Junjie Xie, Baiyong Shen, Hong Xu, Zhaoyuan Hou, Hao Chen
Increasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as cancer diseases resulted from the aberrant lncRNA expression. LncRNA could participate in the cancer progression and develop a significant role through the interaction with proteins. In the present study, we report a lncRNA termed uc.345 that is up-regulated in tumor tissues, compared to the corresponding noncancerous tissues. We found that a higher uc.345 expression level was more frequently observed in tissues with increased depth of invasion and advanced TNM tumor node metastasis T stage...
September 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27686798/long-non-coding-rna-an-emerging-paradigm-of-pancreatic-cancer
#17
T Han, H Hu, M Zhuo, L Wang, J-J Cui, F Jiao, L-W Wang
Pancreatic cancer remains a worldwide issue and burden that is hard to resolve given its low resection rate and chemo-resistance. Early diagnosis and early treatment are critical for conquering pancreatic cancer. Therefore, new biomarkers for diagnosis and prognosis are urgently needed. Previously, researchers mainly focused on protein-coding genetic and epigenetic changes in many types of cancers, and regarded the noncoding part as waste. Recently, however, long non-coding RNA (lncRNA) has emerged as a major participant in carcinogenesis, as it regulates cell proliferation, migration, invasion, metastasis, chemo-resistance, etc...
2016: Current Molecular Medicine
https://www.readbyqxmd.com/read/27644252/long-non-coding-rna-irain-suppresses-apoptosis-and-promotes-proliferation-by-binding-to-lsd1-and-ezh2-in-pancreatic-cancer
#18
Yifan Lian, Juan Wang, Jing Feng, Jie Ding, Zhonghua Ma, Juan Li, Peng Peng, Wei De, Keming Wang
Long non-coding RNA (lncRNA) modulates gene expression, while lncRNA dysregulation is associated with human cancer. Furthermore, while recent studies have shown that lncRNA IRAIN plays an important role in other malignancies, the role of IRAIN in pancreatic cancer (PC) progression remains unclear. In this study, we found that upregulation of lncRNA IRAIN was significantly correlated with tumor size, TNM stage, and lymph node metastasis in a cohort of 37 PC patients. In vitro experiments showed that knockdown of IRAIN by small interfering RNA (siRNA) significantly induced cell apoptosis and inhibited cell proliferation in both BxPC-3 and PANC-1 cells...
November 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27628540/analysis-of-long-non-coding-rna-expression-profiles-in-pancreatic-ductal-adenocarcinoma
#19
Xue-Liang Fu, De-Jun Liu, Ting-Ting Yan, Jian-Yu Yang, Min-Wei Yang, Jiao Li, Yan-Miao Huo, Wei Liu, Jun-Feng Zhang, Jie Hong, Rong Hua, Hao-Yan Chen, Yong-Wei Sun
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression profiles in two public PDAC microarray datasets and identified 34 dysregulated lncRNAs in PDAC. In addition, the expression of 6 selected lncRNAs was confirmed in Ren Ji cohort and pancreatic cell lines, and their association with 80 PDAC patients' clinicopathological features and prognosis was investigated...
September 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27577754/afap1-as1-is-upregulated-and-promotes-esophageal-squamous-cell-carcinoma-cell-proliferation-and-inhibits-cell-apoptosis
#20
Hong-Lei Luo, Ming-de Huang, Jia-Ni Guo, Rui-Hua Fan, Xiao-Tian Xia, Jing-Dong He, Xiao-Fei Chen
Recent findings indicate that long noncoding RNAs (lncRNAs) were dysregulated in many kinds of tumors including esophageal squamous cell carcinoma (ESCC). LncRNA AFAP1-AS1 was found to be upregulated in hepatocellular carcinoma (HCC), lung cancer, colorectal cancer, esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma, and nasopharyngeal carcinoma, while its clinical value and potential function in ESCC are still unknown. Expression of AFAP1-AS1 was measured in 65 ESCC tissues and corresponding noncancerous tissues by quantitative real-time polymerase chain reaction, which revealed that AFAP1-AS1 expression was markedly elevated in ESCC tissues and significantly associated with advanced TNM stage (P = 0...
August 30, 2016: Cancer Medicine
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