Dana Narvaez, Jorge Nadal, Adrian Nervo, María Victoria Costanzo, Claudio Paletta, Fernando E Petracci, Sergio Rivero, Alexis Ostinelli, Berenice Freile, Diego Enrico, Maria Teresa Pombo, Mora Amat, Edgar Danilo Aguirre, Matias Chacon, Federico Waisberg
This narrative review aims to clarify the role of tertiary lymphoid structures in breast cancer. We examine their development, composition, and prognostic value, and current ways of recognizing them. A comprehensive literature review was performed using the PubMed/Medline, Scopus, and EMBASE databases. A significant area of interest in breast cancer research involves targeting immune checkpoint molecules, particularly in the triple-negative subtype, where treatment options remain limited. However, existing biomarkers have limitations in accurately predicting treatment response...
January 17, 2024: Cancers