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leukocyte adhesion

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https://www.readbyqxmd.com/read/29472915/endothelial-cell-focal-adhesion-regulates-transendothelial-migration-and-subendothelial-crawling-of-t-cells
#1
Jaehyun Lee, Kwang Hoon Song, Taeyeob Kim, Junsang Doh
Leukocytes circulating in the blood stream leave out of blood vessels and infiltrate into inflamed tissues to perform immune responses. Endothelial cells (ECs) lining interior of the post-capillary venules regulate various steps of leukocyte extravasation. In response to inflammatory signals, ECs upregulate adhesion molecules and produce/present chemokines to support firm adhesion and intraluminal crawling of leukocytes. They also remodel junctions to facilitate leukocyte transendothelial migration (TEM). While roles of apical/lateral components of EC layers in regulating leukocyte extravasation have been extensively investigated, relatively little attention has been paid to the basal part of EC layers comprising subendothelial spaces...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472353/long-term-management-of-leukocyte-adhesion-deficiency-type-iii-without-hematopoietic-stem-cell-transplantation
#2
Paul Saultier, Sarah Szepetowski, Matthias Canault, Céline Falaise, Marjorie Poggi, Pierre Suchon, Vincent Barlogis, Gérard Michel, Stéphane Loyau, Martine Jandrot-Perrus, Jean-Claude Bordet, Marie-Christine Alessi, Hervé Chambost
No abstract text is available yet for this article.
February 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29466360/combining-metformin-and-esomeprazole-is-additive-in-reducing-sflt-1-secretion-and-decreasing-endothelial-dysfunction-implications-for-treating-preeclampsia
#3
Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan
INTRODUCTION: The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multiorgan injury. We recently identified metformin and esomeprazole as potential treatments for preeclampsia. Both reduce placental and endothelial secretion of sFlt-1 and soluble endoglin, and reduce endothelial dysfunction...
2018: PloS One
https://www.readbyqxmd.com/read/29465790/forkhead-box-c2-promotes-the-invasion-ability-of-human-trophoblast-cells-through-hedgehog-hh-signaling-pathway
#4
Yuhong Zhang, Yangjia Zhang
Embryonic development depends on the normal invasion of trophoblast cells. Forkhead box C2 (FOXC2) is a member of Forkhead box family, which is involved in the tumor cells invasion. The aim of this study was to explore the roles of FOXC2 on the invasion of human trophoblast cells, and further study its molecular mechanism. The mRNA and protein levels of FOXC2 in human normal trophoblast and choriocarcinoma cell lines were analyzed by quantitative real-time PCR (qRT-PCR) and western blot assays, respectively...
February 21, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29464004/biomimetic-nanoparticles-with-enhanced-affinity-towards-activated-endothelium-as-versatile-tools-for-theranostic-drug-delivery
#5
Jonathan O Martinez, Roberto Molinaro, Kelly A Hartman, Christian Boada, Roman Sukhovershin, Enrica De Rosa, Dickson Kirui, Shanrong Zhang, Michael Evangelopoulos, Angela M Carter, James A Bibb, John P Cooke, Ennio Tasciotti
Activation of the vascular endothelium is characterized by increased expression of vascular adhesion molecules and chemokines. This activation occurs early in the progression of several diseases and triggers the recruitment of leukocytes. Inspired by the tropism of leukocytes, we investigated leukocyte-based biomimetic nanoparticles (i.e., leukosomes) as a novel theranostic platform for inflammatory diseases. Methods : Leukosomes were assembled by combining phospholipids and membrane proteins from leukocytes...
2018: Theranostics
https://www.readbyqxmd.com/read/29453336/alternative-splicing-of-alcam-enables-tunable-regulation-of-cell-cell-adhesion-through-differential-proteolysis
#6
Katie E Hebron, Elizabeth Y Li, Shanna A Arnold Egloff, Ariana K von Lersner, Chase Taylor, Joep Houkes, David K Flaherty, Adel Eskaros, Thomas P Stricker, Andries Zijlstra
While many adhesion receptors are known to influence tumor progression, the mechanisms by which they dynamically regulate cell-cell adhesion remain elusive. We previously identified Activated Leukocyte Cell Adhesion Molecule (ALCAM) as a clinically relevant driver of metastasis and hypothesized that a tunable mechanism of ectodomain shedding regulates its contribution to dissemination. To test this hypothesis, we examined an under-explored ALCAM splice variant (ALCAM-Iso2) and demonstrated that loss of the membrane-proximal region of ALCAM (exon 13) increased metastasis four-fold...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449332/inhibition-of-endothelial-notch1-signaling-attenuates-inflammation-by-reducing-cytokine-mediated-histone-acetylation-at-inflammatory-enhancers
#7
Lars la Cour Poulsen, Reidunn Jetne Edelmann, Stig Krüger, Rodrigo Diéguez-Hurtado, Akshay Shah, Tor Espen Stav-Noraas, Anastasia Renzi, Monika Szymanska, Junbai Wang, Manuel Ehling, Rui Benedito, Monika Kasprzycka, Espen Bækkevold, Olav Sundnes, Kim S Midwood, Helge Scott, Philippe Collas, Christian W Siebel, Ralf H Adams, Guttorm Haraldsen, Eirik Sundlisæter, Johanna Hol
OBJECTIVE: Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and NF-κB components cannot explain the transcriptional selectivity exerted by NOTCH1 in this context. APPROACH AND RESULTS: Observing that Cre/Lox-induced conditional mutations of endothelial Notch modulated inflammation in murine contact hypersensitivity, we found that IL (interleukin)-1β stimulation induced rapid recruitment of RELA to genomic sites occupied by NOTCH1-RBPJ and that NOTCH1 knockdown reduced H3K27 acetylation at a subset of NF-κB-directed inflammatory enhancers...
February 15, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29448951/t-arms-pcr-genotyping-of-snp-rs445709131-using-thermostable-strand-displacement-polymerase
#8
Rafeeque R Alyethodi, Umesh Singh, Sushil Kumar, Rani Alex, Rajib Deb, Gyanendra S Sengar, T V Raja, B Prakash
OBJECTIVES: In a recent publication, we reported the successful use of tetra primer-amplification refractory mutation system based polymerase chain reaction (T-ARMS-PCR) for genotyping of rs445709131-SNP responsible for the bovine leukocyte adhesion deficiency (BLAD) in cattle. The SNP is characterized by higher GC content of the surrounding region, hence, the previous protocol utilized dimethyl sulfoxide as PCR enhancer. Here, the reaction cocktail was modified with the use of thermostable strand displacement polymerase (SD polymerase) instead of commonly used Taq DNA Polymerase...
February 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29437572/cilostazol-attenuates-angiotensin-ii-induced-abdominal-aortic-aneurysms-but-not-atherosclerosis-in-apolipoprotein-e-deficient-mice
#9
Ryoko Umebayashi, Haruhito A Uchida, Yuki Kakio, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a permanent dilation of the abdominal aorta associated with rupture, which frequently results in fatal consequences. AAA tissue is commonly characterized by localized structural deterioration accompanied with inflammation and profound accumulation of leukocytes, although the specific function of these cells is unknown. Cilostazol, a phosphodiesterase III inhibitor, is commonly used for patients with peripheral vascular disease or stroke because of its anti-inflammatory effect, which is vasoprotective effects through its anti-inflammatory effect...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29434607/the-role-of-the-endothelium-during-antibody-mediated-rejection-from-victim-to-accomplice
#10
REVIEW
Amy Rachael Cross, Denis Glotz, Nuala Mooney
Antibody-mediated rejection (AMR) of solid organ transplants is characterized by the activation and injury of the allograft endothelium. Histological and transcriptomic studies have associated microvascular inflammation and endothelial lesions with the severity of rejection and poor graft outcomes. The allograft endothelium forms the physical barrier between the donor organ and the recipient; this position directly exposes the endothelium to alloimmune responses. However, endothelial cells are not just victims and can actively participate in the pathogenesis of rejection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29433874/acellular-derivatives-of-mesenchymal-stem-cells-prevent-peritoneal-adhesions-in-an-animal-model
#11
Daniel Rojo, Paulette Conget
BACKGROUND: Peritoneal adhesions are nonanatomical connections that bind organs to the abdominal wall or among them. They arise after peritoneal injury, which triggers an inflammatory response followed by a healing process that leads to fibrotic tissue formation. Mesenchymal stem cells and their secretion products, also referred to as acellular derivatives (ACDs), have anti-inflammatory, fibrinolytic, and antifibrogenic properties. The aim of this study was to determine the effect of intraoperative administration of ACD on the appearance, severity, and progression of peritoneal adhesions, in an animal model...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433150/cx3cr1-cx3cl1-axis-mediates-platelet-leukocyte-adhesion-to-arterial-endothelium-in-younger-patients-with-a-history-of-idiopathic-deep-vein-thrombosis
#12
Elena Furio, Maria Jose García-Fuster, Josep Redon, Patrice Marques, Rebeca Ortega, Maria Jesus Sanz, Laura Piqueras
Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups...
February 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29427772/circulating-angiopoietin-2-and-its-soluble-receptor-tie-2-concentrations-are-related-to-inflammatory-markers-in-the-general-population
#13
Elisabeth A Schuldt, Wolfgang Lieb, Marcus Dörr, Markus M Lerch, Henry Völzke, Matthias Nauck, Nele Friedrich
BACKGROUND: The Angiopoietin/Tie (Tyrosine kinase with Ig and EGF homology domains) signaling axis has crucial influences on angiogenesis and the vasculature's reorganization. Moreover, angiopoietin-2 (Ang2) is discussed as a biomarker for diseases' severity and development. Previous studies reported increased Ang2 levels in patients with inflammatory diseases and associations of Ang2 with inflammation markers in relatively small samples. We aimed to assess the relation of Ang2 and Tie2 with inflammation markers in the general population...
February 7, 2018: Cytokine
https://www.readbyqxmd.com/read/29421799/an-international-genetic-survey-of-breed-specific-diseases-in-working-dogs-from-the-united-states-israel-and-poland
#14
Lisa G Shaffer, Christina J Ramirez, Patricia Phelps, Maya Aviram, Marta Walczak, Gila Kahila Bar-Gal, Blake C Ballif
Genetic diseases occur in breeds used for law enforcement. As important team members, dogs are expected to operate at peak performance for several years and are significant investments for both the initial purchase and extensive, specialized training. Previous studies have not focused on causes for retirement or euthanasia as genetic (inherited) versus acquired (environmental). We performed direct mutational analysis for breed-specific conditions on samples from 304 dogs including 267 law enforcement (122 US, 87 Israeli, and 58 Polish) and 37 search and rescue dogs...
February 9, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29408455/omentin-1-ameliorates-the-attachment-of-the-leukocyte-thp-1-cells-to-huvecs-by-targeting-the-transcriptional-factor-klf2
#15
Yuehui Wang, Min Sun, Zhe Wang, Xiaonan Li, Yiyi Zhu, Yanhong Li
Oxidation of low-density lipoproteins (ox-LDL) plays a critical role in endothelial dysfunction and the pathological progression of atherosclerosis by causing leukocyte attachment to endothelial surfaces. Omentin-1, an important adipokine primarily secreted by stromal vascular cells, has displayed various biological functions in diverse tissues. However, little information regarding the effects of omentin-1 on ox-LDL- induced endothelial dysfunction has been reported before. In the current study, we found that omentin-1 significantly reduced the attachment of the leukocyte THP-1 cells to human umbilical vein endothelial cells (HUVECs) in a dose dependent manner...
February 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29406998/prophylactic-use-of-colchicine-in-preventing-radiation-induced-coronary-artery-disease
#16
T O'Herron, J Lafferty
Radiation therapy is one of the primary treatments in fighting breast cancer, one of the most common cancers in the US. One of the dose limiting factors of this therapy is radiation induced heart damage that results from mediastinal radiation. Recently statins, a medication typically used to lower cholesterol levels, have been suggested as a prophylactic treatment to potentially mitigate this process. Similarly, we hypothesized whether colchicine, an anti-inflammatory medication that is presently used in the treatment of gout and pericarditis, might be used to prevent coronary artery disease induced by radiation therapy...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29406386/low-shear-stress-upregulates-the-expression-of-fractalkine-through-the-activation-of-mitogen-activated-protein-kinases-in-endothelial-cells
#17
Amanguli Ruze, Yiwei Zhao, Hui Li, Xiayimaidan Gulireba, Jing Li, Dongyu Lei, Hongyan Dai, Jiang Wu, Xin Zhao, Yongmei Nie
: Fractalkine (FKN) is a cytokine which plays an important role in atherosclerosis and other inflammatory diseases. Studies have shown that FKN induces integrin-independent leukocyte adhesion to primary endothelial cells under physiological flow conditions. Further, increased expression of FKN has been demonstrated in atherosclerotic lesions induced by low shear stress. However, the signal transduction mechanisms involved in low shear stress-induced FKN upregulation are not well characterized. In this study, EA...
February 5, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29403496/recent-advances-in-targeting-cd8-t-cell-immunity-for-more-effective-cancer-immunotherapy
#18
REVIEW
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI). Cytotoxic T lymphocytes (CTL) eliminate malignant cells through recognition by the T-cell receptor (TCR) of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29403302/magnesium-deficiency-and-increased-inflammation-current-perspectives
#19
REVIEW
Forrest H Nielsen
Animal studies have shown that magnesium deficiency induces an inflammatory response that results in leukocyte and macrophage activation, release of inflammatory cytokines and acute-phase proteins, and excessive production of free radicals. Animal and in vitro studies indicate that the primary mechanism through which magnesium deficiency has this effect is through increasing cellular Ca2+, which is the signal that results in the priming of cells to give the inflammatory response. Primary pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-1; the messenger cytokine IL-6; cytokine responders E-selectin, intracellular adhesion molecule-1 and vascular cell adhesion molecule-1; and acute-phase reactants C-reactive protein and fibrinogen have been determined to associate magnesium deficiency with chronic low-grade inflammation (inflammatory stress)...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29397426/the-role-of-neutrophils-in-equine-laminitis
#20
REVIEW
Britta Leise
Equine laminitis is a devastating disease in which failure of the adhesion between the digital dermal and epidermal laminae at the basement membrane results in crippling lameness and structural damage to the foot of the horse. Laminitis occurring secondary to sepsis is known to result from a significant inflammatory response that includes leukocyte emigration into the lamellar tissue. These leukocytes, in particular the neutrophil, have been extensively evaluated in experimental models of sepsis-related laminitis in the horse...
February 3, 2018: Cell and Tissue Research
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