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leukocyte adhesion

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https://www.readbyqxmd.com/read/29223125/tgf-%C3%AE-and-inflammatory-blood-markers-in-prediction-of-intraperitoneal-adhesions
#1
Kamil Torres, Łukasz Pietrzyk, Zbigniew Plewa, Karolina Załuska-Patel, Mariusz Majewski, Elżbieta Radzikowska, Anna Torres
PURPOSE: Intraperitoneal adhesions (IA) develop as a consequence of the healing process in peritoneum injured during surgeries. IA might be formed after all types of surgical interventions regardless the surgical approach with a higher incidence in obese individuals. Here we determine the diagnostic power of TGF-β and blood inflammatory parameters in the prediction of IA in obese patients undergoing second surgical intervention. MATERIALS AND METHODS: Eighty patients were divided into groups according to body mass index (BMI) values and presence of intraperitoneal adhesions (IA)...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29222072/heparan-sulfate-potentiates-leukocyte-adhesion-on-cardiac-fibroblast-by-enhantcing-vcam-1-and-icam-1-expression
#2
Francisco Olivares-Silva, Rodolfo Landaeta, Pablo Aránguiz, Samir Bolivar, Claudio Humeres, Renatto Anfossi, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jiménez, Concepción Peiró, Carlos F Sánchez-Ferrer, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment. This latter cells are responsible of clearing cell debris and releasing cytokines that promote CF differentiation to myofibroblast (CMF), thus initiating scar formation...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29218724/genetic-disruption-of-fractalkine-signaling-leads-to-enhanced-loss-of-cochlear-afferents-following-ototoxic-or-acoustic-injury
#3
Tejbeer Kaur, Kevin K Ohlemiller, Mark E Warchol
Cochlear hair cells are vulnerable to a variety of insults like acoustic trauma and ototoxic drugs. Such injury can also lead to degeneration of spiral ganglion neurons (SGNs), but this occurs over a period of months to years. Neuronal survival is necessary for the proper function of cochlear prosthetics, therefore it is of great interest to understand the mechanisms that regulate neuronal survival in deaf ears. We have recently demonstrated that selective hair cell ablation is sufficient to attract leukocytes into the spiral ganglion (SG), and that fractalkine signaling plays a role in macrophage recruitment and in the survival of auditory neurons...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29214442/shiga-toxin-triggers-endothelial-and-podocyte-injury-the-role-of-complement-activation
#4
REVIEW
Carlamaria Zoja, Simona Buelli, Marina Morigi
Shiga toxin (Stx)-producing Escherichia coli (STEC) is the offending agent in post-diarrhea-associated hemolytic uremic syndrome (HUS), a disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney failure, with thrombi occluding the renal microvasculature. Endothelial dysfunction has been recognized as the trigger event in the development of microangiopathic processes. Glomerular endothelial cells are susceptible to the toxic effects of Stxs that, via nuclear factor kappa B (NF-κB) activation, induce the expression of genes encoding for adhesion molecules and chemokines, culminating in leukocyte adhesion and platelet thrombus formation on the activated endothelium...
December 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29213284/circulatory-immune-cells-in-cushing-syndrome-bystanders-or-active-contributors-to-atherometabolic-injury-a-study-of-adhesion-and-activation-of-cell-surface-markers
#5
Gloria Aranda, Cristina Lopez, Rebeca Fernandez-Ruiz, Yaiza Esteban, Guillermo Garcia-Eguren, Mireia Mora, Irene Halperin, Gregori Casals, Joaquim Enseñat, Felicia A Hanzu
Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombotic inflammation involving immune cells (IMNC). Aim. To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH. Material and Methods. 16 ACTH-dependent CS (ACTH-D), 10 ACTH-independent (ACTH-ID) CS, and 16 healthy controls (C) were included...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29208678/microrna-100-suppresses-chronic-vascular-inflammation-by-stimulation-of-endothelial-autophagy
#6
Franziska Pankratz, Catherine Hohnloser, Xavier Bemtgen, Caterina Jaenich, Sheena Kreuzaler, Imo E Hoefer, Gerard Pasterkamp, Justin Mastroianni, Robert Zeiser, Christian Smolka, Laura A Schneider, Julien Martin, Maike Juschkat, Thomas Helbing, Martin Moser, Christoph Bode, Sebastian Grundmann
Rationale: The interaction of circulating cells within the vascular wall is a critical event in chronic inflammatory processes such as atherosclerosis, but the control of the vascular inflammatory state is still largely unclear. Objective: This study was undertaken to characterize the function of the endothelial-enriched microRNA miR-100 during vascular inflammation and atherogenesis. Methods and Results: Based on a transcriptome analysis of endothelial cells after miR-100 overexpression, we identified miR-100 as potent suppressor of endothelial adhesion molecule expression, resulting in attenuated leukocyte-endothelial interaction in vitro and in vivo as shown by flow cytometry and intravital imaging approach...
December 5, 2017: Circulation Research
https://www.readbyqxmd.com/read/29207960/decreased-expression-of-the-%C3%AE-2-integrin-on-tumor-cells-is-associated-with-a-reduction-in-liver-metastasis-of-colorectal-cancer-in-mice
#7
Aitor Benedicto, Joana Marquez, Alba Herrero, Elvira Olaso, Elzbieta Kolaczkowska, Beatriz Arteta
BACKGROUND: Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its functional role in the metastatic progression to the liver remains unknown. Using in vitro assays and an experimental orthotopic in vivo model of liver metastasis, we aimed to elucidate the role of tumor LFA-1 in the metastatic progression by means of the partial depletion of the β2 subunit of LFA-1, required for integrin activation, firm adhesion and signaling...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207649/sulodexide-recovers-endothelial-function-through-reconstructing-glycocalyx-in-the-balloon-injury-rat-carotid-artery-model
#8
Tianjia Li, Xinnong Liu, Zhewei Zhao, Leng Ni, Changwei Liu
Disruption of endothelial cell function is a principle event in cardiovascular disease. Accordingly, therapies have mostly focused on repairing the endothelium, but little attention has been paid to the reconstruction of glycocalyx, which covers the endothelium and protects the function of endothelial cells. Sulodexide has a similar glycosaminoglycan structure to glycocalyx, so it is assumed to be effective in remodeling the glycocalyx following damage. We assessed the effect of sulodexide on glycocalyx remodeling and endothelial function in the balloon-injury rat carotid artery model...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207576/glycosaminoglycan-mediated-downstream-signaling-of-cxcl8-binding-to-endothelial-cells
#9
Rupert Derler, Bernd Gesslbauer, Corinna Weber, Elisabeth Strutzmann, Ingrid Miller, Andreas Kungl
The recruitment of leukocytes, mediated by endothelium bound chemokine gradients, is a vital process in inflammation. The highly negatively charged, unbranched polysaccharide family of glycosaminoglycans (GAGs), such as heparan sulfate and chondroitin sulfate mediate chemokine immobilization. Specifically the binding of CXCL8 (interleukin 8) to GAGs on endothelial cell surfaces is known to regulate neutrophil recruitment. Currently, it is not clear if binding of CXCL8 to GAGs leads to endothelial downstream signaling in addition to the typical CXCR1/CXCR2 (C-X-C motif chemokine receptor 1 and 2)-mediated signaling which activates neutrophils...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29207103/epigenetic-alterations-of-the-igf2-promoter-and-the-effect-of-mir%C3%A2-483%C3%A2-5p-on-its-target-gene-expression-in-esophageal-squamous-cell-carcinoma
#10
Han Zhang, Xiaowei Shi, Weidong Chang, Yingying Li, Li Wang, Linsong Wang
Esophageal squamous cell carcinoma (ESCC) is one of the most widespread malignancies in China. MicroRNAs (miRNAs/miRs) are endogenous evolutionarily‑conserved small non‑coding RNAs that are able to regulate ESCC formation and deterioration by negatively regulating specific target genes. In the present study, the expression levels of miR‑483‑5p and its associated mRNAs were measured by quantitative polymerase chain reaction (PCR) analysis, and the methylation levels of the insulin‑like growth factor 2 (Igf2) promoter were detected via the methylation‑specific PCR method in serum and tissues from patients with ESCC...
November 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207063/forskolin-attenuates-retinal-inflammation-in-diabetic-mice
#11
Zhi-Peng You, Bin Xiong, Yu-Lan Zhang, Lu Shi, Ke Shi
The present study aimed to investigate the effect of forskolin on retinal inflammation under diabetic conditions. C57BL/6 mice were randomly divided into normal control, diabetic control and forskolin treatment groups. The diabetic model was established by intraperitoneal injection of streptozotocin. The forskolin treatment group received intragastrical administration of forskolin for 12 weeks, the other two groups received an equal amount of PBS. At 21 weeks following diabetic induction, an immunoblotting test was conducted to investigate the expression of two inflammatory factors: Intercellular adhesion molecule-1 (ICAM‑1) and tumor necrosis factor‑α (TNF‑α)...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207049/coordinated-microrna-mrna-expression-profiles-reveal-a-putative-mechanism-of-corneal-epithelial-cell-transdifferentiation-from-skin-epidermal-stem-cells
#12
Yanjie Guo, Xiya Ma, Weini Wu, Mingyan Shi, Junlong Ma, Yaping Zhang, Erkang Zhao, Xueyi Yang
Skin epidermal stem cells (SESCs), which share a single origin with corneal epithelial cells (CECs), are considered to be one of the most ideal seed cells for the construction of tissue engineered corneas. However, the mechanism underlying the transdifferentiation of SESCs to CECs has not been fully elucidated. In the present study, to identify critical microRNAs (miRNAs/miRs) and genes that regulate the transdifferentiation of SESCs to CECs, SESCs and CECs were collected from sheep and used for small RNA sequencing and mRNA microarray analyses...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29203148/diabetic-retinopathy-pathogenesis-and-the-ameliorating-effects-of-melatonin-involvement-of-autophagy-inflammation-and-oxidative-stress
#13
REVIEW
Ehsan Dehdashtian, Saeed Mehrzadi, Bahman Yousefi, Azam Hosseinzadeh, Russel J Reiter, Majid Safa, Habib Ghaznavi, Masood Naseripour
Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains as one of the major causes of vision loss worldwide. The release of pro-inflammatory cytokines and the adhesion of leukocytes to retinal capillaries are initial events in DR development. Inflammation, ER stress, oxidative stress and autophagy are major causative factors involved in the pathogenesis of DR. Diabetes associated hyperglycemia leads to mitochondrial electron transport chain dysfunction culminating in a rise in ROS generation...
December 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/29194344/direct-peritoneal-resuscitation-alters-leukocyte-infiltration-in-the-lung-after-acute-brain-death
#14
Jessica L Weaver, Paul J Matheson, Amy Matheson, Cynthia D Downard, R Neal Garrison, Jason W Smith
BACKGROUND: Brain death is associated with significant lung injury and inflammation. This has been associated with worse long-term outcomes for transplanted lungs. Direct peritoneal resuscitation (DPR) reduces systemic inflammation in brain death and improves lung procurement rate. The effect of DPR on macrophage and neutrophil infiltration in the lungs is not known. METHODS: Male Sprague-Dawley rats had a 4F Fogarty catheter inserted into the skull and the balloon inflated until brain death was achieved...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29181415/endothelial-stat3-modulates-protective-mechanisms-in-a-mouse-ischemia-reperfusion-model-of-acute-kidney-injury
#15
Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry E Mang, Pierre C Dagher, Takashi Hato, Timothy A Sutton
STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of the role STAT3 signaling plays in response to organ injury following diverse insults. Acute kidney injury (AKI) from ischemia-reperfusion injury is a common clinical entity with devastating consequences, and the recognition that endothelial alterations contribute to kidney dysfunction in this setting is of growing interest. Consequently, we used a mouse with a genetic deletion of Stat3 restricted to the endothelium to examine the role of STAT3 signaling in the pathophysiology of ischemic AKI...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29176405/lipopeptide-pam3cys4-synergizes-n-formyl-met-leu-phe-fmlp-induced-calcium-transients-in-mouse-neutrophils
#16
Renyu Ding, Ganqiong Xu, Yan Feng, Lin Zou, Wei Chao
N-Formyl-Met-Leu-Phe (fMLP), a mimic of N-formyl oligopeptides that are released from bacteria, is a potent leukocyte chemotactic factor. It induces intracellular calcium ([Ca]i) transient that is important for various neutrophil biological functions, e.g., adhesion, ROS and cytokine productions. Toll-like receptors (TLRs), an essential part of host innate immunity, regulate neutrophil activities, but their role in [Ca]i signaling is less clear. In the current study, we examined the effect of several TLR ligands, including Pam3Cys4 (TLR1/2), lipopolysaccharide (LPS, TLR4), and lipoteichoic acid (LTA, TLR2/6), on calcium signaling and on the fMLP-induced [Ca]i transients in mouse neutrophils loaded with Fura-2/AM...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29175057/simvastatin-blocks-soluble-ssao-vap-1-release-in-experimental-models-of-cerebral-ischemia-possible-benefits-for-stroke-induced-inflammation-control
#17
Ping Sun, Mar Hernandez-Guillamón, Mireia Campos-Martorell, Alba Simats, Joan Montaner, Mercedes Unzeta, Montse Solé
Beyond cholesterol reduction, statins mediate their beneficial effects on stroke patients through pleiotropic actions. They have shown anti-inflammatory properties by a number of different mechanisms, including the inhibition of NF-κB transcriptional activity and the consequent increase and release of adhesion molecules. We have studied simvastatin's effects on the vascular enzyme semicarbazide-sensitive amine oxidase/vascular adhesion protein 1 (SSAO/VAP-1), which is involved in stroke-mediated brain injury...
November 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29172260/the-lys469glu-k469e-polymorphism-of-the-inflammatory-gene-intercellular-adhesion-molecule-1-lacks-any-apparent-role-in-the-polycystic-ovary-syndrome-in-kashmiri-women-a-case-control-study
#18
Syed Douhath Yousuf, Mohammad Ashraf Ganie, Mohammad Afzal Zargar, Shajr Ul Amin, Gulzar A Bhat, Akbar Masood, Fouzia Rashid
Background: Polycystic ovary syndrome (PCOS), associated with a state of low grade chronic inflammation, depends on multiple genetic and environmental factors. Elevated levels of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1) have been demonstrated in affected women. Recent evidence indicates a significant linkage between chromosome 19p13 loci and multifactorial diseases that have an inflammatory component. The aim of this study was to assess the possible association of the lys469glu (K469E) polymorphism of the ICAM-1 gene located on chromosome 19p13 with risk of PCOS in Kashmiri women...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29171910/mutant-huntingtin-protein-expression-and-blood-spinal-cord-barrier-dysfunction-in-huntington-s-disease
#19
Giacomo Sciacca, Francesca Cicchetti
OBJECTIVE: The aim of the study was to assess the distribution, frequency and specific location of mutant huntingtin protein (mHTT) aggregates - the pathological hallmark of HD - within the various compartments of the spinal cord and their potential impact on the local vasculature and BSCB. METHODS: We performed a series of post-mortem immunohistochemical and immunofluorescent stainings, as well as western blot analyses, on cervical and lumbar sections of the spinal cord in patients diagnosed with HD (n=11 of all grades of disease severity) along with sex and age-matched healthy controls (n=9)...
November 24, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29170041/nf%C3%AE%C2%BAb-transcription-factor-p65-immunohistochemistry-in-leprosy-dermal-microvasculature
#20
Luciana Mota Silva, Kelly Emi Hirai, Jorge Rodrigues de Sousa, Juarez de Souza, Leônidas Braga Dias, Francisca Regina Oliveira Carneiro, Tinara Leila de Souza Aarão, Hellen Thais Fuzii, Juarez Antonio Simões Quaresma
Leprosy caused by Mycobacterium leprae is characterized by a spectrum of clinical manifestations that are determined by the predominant immunological profile of the host. The recruitment of leukocytes to the sites of injury can influence the development of these profiles. Cell adhesion molecules such as ICAM-1, VCAM-1 and CD62E participate in this process and their expression is regulated by transcriptions factors such as NFκB. To correlate the expression of cell adhesion molecules and NFκB (p65) in leprosy lesions, 30 skin biopsies of patients with leprosy [16 with the tuberculoid (TT) or borderline tuberculoid (BT) forms and 14 with the lepromatous (LL) or borderline lepromatous (BL) forms] were analyzed by immunohistochemistry...
November 20, 2017: Microbial Pathogenesis
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