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Frontotemporal schizophrenia

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https://www.readbyqxmd.com/read/29759822/multivariate-relationships-between-cognition-and-brain-anatomy-across-the-psychosis-spectrum
#1
Amanda L Rodrigue, Jennifer E McDowell, Neeraj Tandon, Matcheri S Keshavan, Carol A Tamminga, Godfrey D Pearlson, John A Sweeney, Robert D Gibbons, Brett A Clementz
BACKGROUND: Cognitive and structural brain abnormalities range from mild to severe in psychosis. The relation of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain. METHODS: Participants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29752072/tar-dna-binding-protein-43-and-disrupted-in-schizophrenia-1-coaggregation-disrupts-dendritic-local-translation-and-mental-function-in-frontotemporal-lobar-degeneration
#2
Ryo Endo, Noriko Takashima, Yoko Nekooki-Machida, Yusuke Komi, Kelvin Kai-Wan Hui, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Akira Sawa, Motomasa Tanaka
BACKGROUND: Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of cerebral cortex. Furthermore, patients with FTLD display mental dysfunction in multiple behavioral dimensions. Nevertheless, their molecular origin for psychiatric symptoms remains unclear. METHODS: In FTLD neurons and mouse models with TDP-43 aggregates, we examined coaggregation between TDP-43 and disrupted in schizophrenia 1 (DISC1), a key player in the pathology of mental conditions and its effects on local translation in dendrites and psychiatric behaviors...
March 29, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29609959/impairment-of-social-cognition-in-neurological-diseases
#3
REVIEW
H Duclos, B Desgranges, F Eustache, M Laisney
Social cognition is impaired in a large number of neurological afflictions, including neurodegenerative diseases, neuropsychiatric disorders and neurodevelopmental syndromes, and has become a significant element in differential diagnoses. This report describes the different processes involved in social cognition and the way in which they work together to allow adapted behaviors. This is then followed by the numerous clinical symptoms of social behavioral disturbances and social cognition performance in different neurological afflictions such as frontotemporal lobar degeneration, Alzheimer's disease and schizophrenia...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29608131/do-patients-with-different-psychiatric-disorders-show-altered-social-decision-making-a-systematic-review-of-ultimatum-game-experiments-in-clinical-populations
#4
Barbara Hinterbuchinger, Alexander Kaltenboeck, Josef Severin Baumgartner, Nilufar Mossaheb, Fabian Friedrich
BACKGROUND: Impairments in social functioning are a common feature of psychiatric disorders. Game paradigms pose a unique way for studying how people make decisions in interpersonal contexts. In the last decade, researchers have started to use these paradigms to study social decision-making in patients with psychiatric disorders. PURPOSE: The aim of this systematic literature review is to summarise the currently available evidence on the behaviour of patients with psychiatric disorders in the commonly used Ultimatum Game (UG)...
April 2, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29481320/association-between-structural-and-functional-brain-alterations-in-drug-free-patients-with-schizophrenia-a-multimodal-meta-analysis
#5
Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong, John A Sweeney, Su Lui
BACKGROUND: Neuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia...
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29480190/the-first-historically-reported-italian-family-with-ftd-als-teaches-a-lesson-on-c9orf72-re-clinical-heterogeneity-and-oligogenic-inheritance
#6
Maria Pia Giannoccaro, Anna Bartoletti-Stella, Silvia Piras, Alfonsina Casalena, Federico Oppi, Giovanni Ambrosetto, Pasquale Montagna, Rocco Liguori, Piero Parchi, Sabina Capellari
BACKGROUND: In 1969, Dazzi and Finizio reported the second observation of frontotemporal dementia (FTD) - amyotrophic lateral sclerosis (ALS) association in a large Italian kindred affected by an autosomal dominant form of ALS with high penetrance, frequent bulbar onset, and frequent cognitive decline. OBJECTIVE: To expand the original characterization of this family and report the link with the C9orf72 repeat expansion (RE). METHODS: We followed or reviewed the medical records of thirteen patients belonging to the original family and performed genetic analyses in four individuals...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29456514/right-frontotemporal-cortex-mediates-the-relationship-between-cognitive-insight-and-subjective-quality-of-life-in-patients-with-schizophrenia
#7
Shenghong Pu, Kazuyuki Nakagome, Masashi Itakura, Hiroaki Ohtachi, Masaaki Iwata, Izumi Nagata, Koichi Kaneko
Although prior studies identified a relationship between cognitive insight and subjective quality of life (QOL) in patients with schizophrenia, the brain regions mediating this relationship remain unknown. Recent studies have shown that the ventrolateral prefrontal cortex may be particularly important for cognitive insight in individuals with schizophrenia. Here, we examined whether frontotemporal function mediates the relationship between cognitive insight and QOL in 64 participants, including 32 patients with schizophrenia and 32 healthy controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29454512/frontal-and-temporal-cortical-volume-white-matter-tract-integrity-and-hemispheric-asymmetry-in-schizotypal-personality-disorder
#8
Chi C Chan, Philip R Szeszko, Edmund Wong, Cheuk Y Tang, Caitlin Kelliher, Justin D Penner, M Mercedes Perez-Rodriguez, Daniel R Rosell, Margaret McClure, Panos Roussos, Antonia S New, Larry J Siever, Erin A Hazlett
Abnormalities in temporal and frontal cortical volume, white matter tract integrity, and hemispheric asymmetry have been implicated in schizophrenia-spectrum disorders. Schizotypal personality disorder can provide insight into vulnerability and protective factors in these disorders without the confounds associated with chronic psychosis. However, multimodal imaging and asymmetry studies in SPD are sparse. Thirty-seven individuals with SPD and 29 healthy controls (HC) received clinical interviews and 3T magnetic resonance T1-weighted and diffusion tensor imaging scans...
February 14, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29445197/differences-in-frontotemporal-dysfunction-during-social-and-non-social-cognition-tasks-between-patients-with-autism-spectrum-disorder-and-schizophrenia
#9
Keiko Hirata, Kazuteru Egashira, Kenichiro Harada, Mami Nakashima, Masako Hirotsu, Shinji Isomura, Toshio Watanuki, Toshio Matsubara, Yoichi Kaku, Hiroshi Kaneyuki, Yoshifumi Watanabe, Koji Matsuo
Although literature evidence suggests deficits in social and non-social cognition in patients with autistic spectrum disorder (ASD) and schizophrenia (SCZ), the difference in neural correlates of the impairments between the two disorders has not been elucidated. We examined brain function in response to a non-social cognition and a social cognition task using functional near-infrared spectroscopy (fNIRS) in 13 patients with ASD, 15 patients with SCZ, and 18 healthy subjects. We assessed the brain function of participants using a verbal fluency task and an emotional facial recognition task...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29244020/association-between-structural-and-functional-brain-alterations-in-drug-free-patients-with-schizophrenia-a-multimodal-meta-analysis
#10
Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong, John A Sweeney, Su Lui
BACKGROUND: Neuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia...
December 15, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29206399/association-between-structural-and-functional-brain-alterations-in-drug-free-patients-with-schizophrenia-a-multimodal-meta-analysis
#11
Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong, John Sweeney, Su Lui
Background: Neuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta­-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia...
December 5, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28990258/baseline-connectome-modular-abnormalities-in-the-childhood-phase-of-a-longitudinal-study-on-individuals-with-chromosome-22q11-2-deletion-syndrome
#12
Liang Zhan, Lisanne M Jenkins, Aifeng Zhang, Giorgio Conte, Angus Forbes, Danielle Harvey, Kathleen Angkustsiri, Naomi J Goodrich-Hunsaker, Courtney Durdle, Aaron Lee, Cyndi Schumann, Owen Carmichael, Kristopher Kalish, Alex D Leow, Tony J Simon
Occurring in at least 1 in 3,000 live births, chromosome 22q11.2 deletion syndrome (22q11DS) produces a complex phenotype that includes a constellation of medical complications such as congenital cardiac defects, immune deficiency, velopharyngeal dysfunction, and characteristic facial dysmorphic features. There is also an increased incidence of psychiatric diagnosis, especially intellectual disability and ADHD in childhood, lifelong anxiety, and a strikingly high rate of schizophrenia spectrum disorders, which occur in around 30% of adults with 22q11DS...
January 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/28932600/abnormal-n400-semantic-priming-effect-may-reflect-psychopathological-processes-in-schizophrenia-a-twin-study
#13
Anuradha Sharma, Heinrich Sauer, Holger Hill, Claudia Kaufmann, Stephan Bender, Matthias Weisbrod
OBJECTIVE: Activation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia. METHODS: We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task...
2017: Schizophrenia Research and Treatment
https://www.readbyqxmd.com/read/28882707/functional-connectivity-of-large-scale-brain-networks-in-patients-with-anti-nmda-receptor-encephalitis-an-observational-study
#14
Michael Peer, Harald Prüss, Inbal Ben-Dayan, Friedemann Paul, Shahar Arzy, Carsten Finke
BACKGROUND: In anti-NMDA receptor (NMDAR) encephalitis, antibody-mediated dysfunction of NMDARs causes severe neuropsychiatric symptoms, including psychosis, memory deficits, and movement disorders. However, it remains elusive how antibody-mediated NMDAR dysfunction leads to these symptoms, and whether the symptoms arise from impairment in specific brain regions and the interactions between impaired regions. METHODS: In this observational study, we recruited 43 patients with anti-NMDAR encephalitis from a tertiary university hospital and 43 age-matched and sex-matched healthy controls without a history of neurological or psychiatric disorders, who were recruited from the general population of Berlin...
October 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28749089/cognitive-deficits-in-patients-with-neuropsychiatric-symptoms-a-comparative-study-between-behavioral-variant-frontotemporal-dementia-and-primary-psychiatric-disorders
#15
COMPARATIVE STUDY
Everard G B Vijverberg, Sigfried Schouws, Paul David Meesters, Esmée Verwijk, Hannie Comijs, Ted Koene, Charlotte Schreuder, Aartjan Beekman, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemieke Dols
OBJECTIVE: To compare neuropsychological profiles in behavioral variant frontotemporal dementia (bvFTD) with its most common primary psychiatric differential diagnoses, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia, in older patients with active symptoms. METHODS: We included patients from different cohorts with MDD (DSM-IV-TR: 296.20-296.23, 296.30-296.33; n = 42; mean ± SD age, 72.0 ± 8.0 years; female = 57.1%) included from 2002 to 2007, noneuthymic BD (DSM-IV-TR: 296...
September 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28612661/is-there-an-association-between-mismatch-negativity-and-cortical-thickness-in-schizophrenia-patients
#16
Jiyoon J Seol, Minah Kim, Kwang Hyuk Lee, Ji-Won Hur, Kang Ik K Cho, Tae Young Lee, Chun Kee Chung, Jun Soo Kwon
INTRODUCTION: Mismatch negativity (MMN) is thought to reflect preattentive, automatic auditory processing. Reduced MMN amplitude is among the most robust findings in schizophrenia research. MMN generators have been shown to be located in the temporal and frontal cortices, which are key areas in the pathophysiology of schizophrenia. This study investigated whether frontotemporal cortical thickness was associated with reduced MMN current source density (CSD) strength in patients with schizophrenia...
November 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28558941/effects-of-aripiprazole-versus-risperidone-on-brain-activation-during-planning-and-social-emotional-evaluation-in-schizophrenia-a-single-blind-randomized-exploratory-study
#17
Edith J Liemburg, Frank van Es, Henderikus Knegtering, André Aleman
Impaired function of prefrontal brain networks may be the source of both negative symptoms and neurocognitive problems in psychotic disorders. Whereas most antipsychotics may decrease prefrontal activation, the partial dopamine D2-receptor agonist aripiprazole is hypothesized to improve prefrontal function. This study investigated whether patients with a psychotic disorder would show stronger activation of prefrontal areas and associated regions after treatment with aripiprazole compared to risperidone treatment...
October 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28507318/cerebellar-volume-and-cerebellocerebral-structural-covariance-in-schizophrenia-a-multisite-mega-analysis-of-983-patients-and-1349-healthy-controls
#18
T Moberget, N T Doan, D Alnæs, T Kaufmann, A Córdova-Palomera, T V Lagerberg, J Diedrichsen, E Schwarz, M Zink, S Eisenacher, P Kirsch, E G Jönsson, H Fatouros-Bergman, L Flyckt, G Pergola, T Quarto, A Bertolino, D Barch, A Meyer-Lindenberg, I Agartz, O A Andreassen, L T Westlye
Although cerebellar involvement across a wide range of cognitive and neuropsychiatric phenotypes is increasingly being recognized, previous large-scale studies in schizophrenia (SZ) have primarily focused on supratentorial structures. Hence, the across-sample reproducibility, regional distribution, associations with cerebrocortical morphology and effect sizes of cerebellar relative to cerebral morphological differences in SZ are unknown. We addressed these questions in 983 patients with SZ spectrum disorders and 1349 healthy controls (HCs) from 14 international samples, using state-of-the-art image analysis pipelines optimized for both the cerebellum and the cerebrum...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28467893/meta-analysis-of-the-effects-of-intranasal-oxytocin-on-interpretation-and-expression-of-emotions
#19
REVIEW
Jenni Leppanen, Kah Wee Ng, Kate Tchanturia, Janet Treasure
Accurate interpretation and appropriate expression of emotions are key aspects of social-cognition. Several mental disorders are characterised by transdiagnostic difficulties in these areas and, recently, there has been increasing interest in exploring the effects of oxytocin on social-emotional functioning. This review consists of 33 studies. Fifteen of the studies included people with autism spectrum disorder, schizophrenia, borderline personality disorder, frontotemporal dementia, anorexia nervosa, bulimia nervosa, post-traumatic stress disorder, depression, and opioid and alcohol dependence...
July 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28399440/altered-effective-brain-connectivity-at-early-response-of-antipsychotics-in-first-episode-schizophrenia-with-auditory-hallucinations
#20
Leilei Zheng, Weibo Liu, Wei He, Shaohua Yu, Guodong Zhong
OBJECTIVE: This study aimed to examine the alterations of cortical connectivity in first-episode schizophrenia (FES) with auditory hallucinations at early response of antipsychotics. METHODS: This was a nonexperimental control of medication study. We measured the cortical activity of 20 medicated patients with FES (medicated group), 19 nonmedicated patients with FES (nonmedicated group), and 22 healthy controls using electroencephalogram during eye-open resting state...
June 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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