Xi Lu, Yanxiang Wang, Wei Guo, Zhimeng Zhang, Xinxin Hu, Tongying Nie, Xinyi Yang, Congran Li, Xiukun Wang, Xue Li, Yun Lu, Guoqing Li, Youwen Zhang, Lang Sun, Jing Pang, Xuefu You
Enterococci can cause various infectious diseases, including urinary tract infection, wound infection, and life-threatening endocarditis and meningitis. The emergence and transmission of vancomycin-resistant enterococci (VRE) have presented a challenge to clinical treatment. There is an urgent need to develop new strategies to fight against this pathogen. This study investigated the antibacterial and anti-biofilm activity of celastrol (CEL), a natural product originating from Tripterygium wilfordii Hook F, against enterococci, and its adjuvant capacity of restoring the susceptibility of VRE to vancomycin in vitro and in vivo ...
January 9, 2023: Microbiology Spectrum