William S Hambright, Victoria R Duke, Adam D Goff, Alex W Goff, Lucas T Minas, Heidi Kloser, Xueqin Gao, Charles Huard, Ping Guo, Aiping Lu, John Mitchell, Michael Mullen, Charles Su, Tamara Tchkonia, Jair M Espindola Netto, Paul D Robbins, Laura J Niedernhofer, James L Kirkland, Chelsea S Bahney, Marc Philippon, Johnny Huard
Chronic conditions associated with aging have proven difficult to prevent or treat. Senescence is a cell fate defined by loss of proliferative capacity and the development of a pro-inflammatory senescence-associated secretory phenotype comprised of cytokines/chemokines, proteases, and other factors that promotes age-related diseases. Specifically, an increase in senescent peripheral blood mononuclear cells (PBMCs), including T cells, is associated with conditions like frailty, rheumatoid arthritis, and bone loss...
May 6, 2024: Aging Cell