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Fetal middle cerebral arteries

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https://www.readbyqxmd.com/read/28713510/color-doppler-indices-of-proximal-and-distal-parts-of-middle-cerebral-artery-in-fetuses-with-intrauterine-growth-restriction
#1
Farhad Naleini, Mohammad Farzizadeh, Abdolmajid Taheri, Ayoob Rostamzadeh, Daryoush Fatehi
INTRODUCTION: Intrauterine growth restriction (IUGR) is a major clinical issue for pregnant women. The purpose of this study was to evaluate color Doppler indices of the proximal and distal parts of the middle cerebral artery (MCA) of the fetus. METHODS: In this cross-sectional study, 350 pregnant patients, with gestation age of 32-40 who were suspected to have intrauterine growth restriction, participated. The patients were referred for color Doppler sonography at the Imam Reza Hospital (Kermanshah, Iran) from May 2011 to September 2012...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28708272/prognostic-accuracy-of-cerebroplacental-ratio-and-middle-cerebral-artery-doppler-for-adverse-perinatal-outcomes-a-systematic-review-and-meta-analysis
#2
REVIEW
Charlotte A Schreurs, Marjon A de Boer, Martijn W Heymans, Linda J Schoonmade, Patrick M M Bossuyt, Ben Willem J Mol, Christianne J M de Groot, Caroline J Bax
OBJECTIVE: Ultrasonographic assessment of the cerebroplacental ratio (CPR) and middle cerebral artery (MCA) Doppler is widely used as an additional method to umbilical artery (UA) Doppler to identify fetuses at risk of adverse perinatal outcomes. However, reported estimates of its accuracy vary considerably. We conducted a systematic review with meta-analysis of studies on the prognostic accuracy of CPR and MCA Doppler, and compared this to UA Doppler. METHODS: We queried PubMed, EMBASE, the Cochrane Library, and ClinicalTrials...
July 14, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28708246/three-dimensional-power-doppler-evaluation-of-cerebral-vascular-blood-flow-a-novel-tool-in-the-assessment-of-fetal-growth-restriction
#3
Katherine R Goetzinger, Alison G Cahill, Linda Odibo, George A Macones, Anthony O Odibo
OBJECTIVES: To determine whether fetuses with fetal growth restriction (FGR) are more likely to have abnormal cerebral vascular flow patterns compared to fetuses who are appropriate for gestational age (AGA) when quantified by using 3-dimensional (3D) power Doppler ultrasound. METHODS: We conducted a prospective cohort study of singleton gestations presenting for growth ultrasound examination between 24 and 36 weeks' gestation. Patients with FGR (estimated fetal weight < 10th percentile) were enrolled and matched 1:1 for gestational age (±7 days) with AGA fetuses...
July 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28707059/a-prospective-cohort-study-on-the-prediction-of-fetal-distress-and-neonatal-status-with-arterial-and-venous-doppler-measurements-in-appropriately-grown-term-fetuses
#4
Ihsan Atabay, Semir Kose, Erkan Cagliyan, Bora Baysal, Ebru Yucesoy, Sabahattin Altunyurt
PURPOSE: To assess the predictive power of the cerebro-placental ratio (CPR) and the venous-arterial index (VAI) for the development of intrapartum fetal distress (FD) and neonatal intensive care unit (NICU) admission. METHODS: Fetal umbilical artery, middle cerebral artery and umbilical vein Doppler measurements were obtained before the active phase of labor in 311 singleton pregnancies at ≥37 weeks. A continuous electronic fetal monitorization was applied, and an umbilical cord blood sample was obtained for each participant...
July 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28700818/fetal-mca-doppler-to-time-intrauterine-transfusions-in-red-cell-alloimmunisation-a-randomised-trial
#5
Jodie M Dodd, Chad Andersen, Jan E Dickinson, Jennie Louise, Andrea Deussen, Rosalie M Grivell, Liliana Voto, Mark D Kilby, Rory Windrim, Greg Ryan
OBJECTIVES: Red cell alloimmunisation affects up to 0.6% of all live births, and can be successfully treated with intrauterine fetal blood transfusion. Fetal middle cerebral artery (MCA) Doppler peak systolic velocity (PSV) is a non-invasive test, to identify fetal anaemia and requiring intrauterine transfusion (IUT). Traditionally, timing of subsequent IUTs has involved estimating a fall in fetal haematocrit of 1% per day, or a fall in fetal haemoglobin of 0.3 g/dL per day. The aim of this pragmatic multi-centre randomised trial was to evaluate whether Doppler MCA-PSV in the fetus that has undergone one IUT for anaemia secondary to red cell alloimmunisation was non-inferior to timing IUT by timing based on predicting the fall in fetal haematocrit or fetal haemoglobin, without compromising infant haemoglobin at birth...
July 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28695721/aortic-isthmus-shunt-dynamics-in-normal-and-complicated-monochorionic-pregnancies
#6
Viola Seravalli, Dana Block-Abraham, Cyrethia McShane, Sarah Millard, Ahmet Baschat, Jena Miller
OBJECTIVE: To study fetal aortic isthmus (AoI) shunt dynamics in monochorionic (MC) twins. METHODS: Normal and complicated MC pregnancies were prospectively enrolled. The relationship of isthmus flow index (IFI) with Doppler parameters of umbilical artery (UA), descending aorta (DAo), middle cerebral artery (MCA), and ductus venosus (DV), and with left and right ventricular cardiac output and stroke volume was studied. RESULTS: The IFI was obtained in 180 examinations from 48 pregnancies (24 twin-twin-transfusion syndrome, TTTS; 4 selective intrauterine growth restriction, sIUGR; 12 TTTS+sIUGR; 8 uncomplicated)...
July 11, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28693788/fetal-growth-restriction-with-brain-sparing-neurocognitive-and-behavioral-outcomes-at-12-years-of-age
#7
Fenny Beukers, Cornelieke S H Aarnoudse-Moens, Mirjam M van Weissenbruch, Wessel Ganzevoort, Johannes B van Goudoever, Aleid G van Wassenaer-Leemhuis
OBJECTIVE: To study neurocognitive functions and behavior in children with a history of fetal growth restriction (FGR) with brain sparing. We hypothesized that children with FGR would have poorer outcomes on these domains. STUDY DESIGN: Subjects were 12-year-old children with a history of FGR born to mothers with severe early-onset hypertensive pregnancy disorders (n = 96) compared with a normal functioning full term comparison group with a birth weight ≥2500 g (n = 32)...
July 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28648573/personalized-treatment-with-immunoadsorption-and-intravenous-immunoglobulin-in-a-case-of-severe-rh-alloimmunization-during-pregnancy-unresponsive-to-plasma-exchange
#8
Anna Colpo, Tiziana Tison, Maria Teresa Gervasi, Cinzia Vio, Maria Vicarioto, Giustina De Silvestro, Piero Marson
INTRODUCTION: Despite prophylaxis, a small proportion of RhD-negative women may develop anti-D antibodies after a sensitizing event occurring during pregnancy or delivery of a D-positive baby. Intrauterine transfusion (IUT) is the treatment of choice in case of fetal anemia, but it cannot be performed early during pregnancy. Combined treatment with therapeutic plasma-exchange (TPE) and intravenous immunoglobulin (IVIG) can avoid or delay IUT. Immunoadsorption (IA) could represent a more effective treatment in selected cases...
June 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28645895/multiparity-improves-outcomes-after-cerebral-ischemia-in-female-mice-despite-features-of-increased-metabovascular-risk
#9
Rodney M Ritzel, Anita R Patel, Monica Spychala, Rajkumar Verma, Joshua Crapser, Edward C Koellhoffer, Anna Schrecengost, Evan R Jellison, Liang Zhu, Venugopal Reddy Venna, Louise D McCullough
Females show a varying degree of ischemic sensitivity throughout their lifespan, which is not fully explained by hormonal or genetic factors. Epidemiological data suggest that sex-specific life experiences such as pregnancy increase stroke risk. This work evaluated the role of parity on stroke outcome. Age-matched virgin (i.e., nulliparous) and multiparous mice were subjected to 60 min of reversible middle cerebral artery occlusion and evaluated for infarct volume, behavioral recovery, and inflammation. Using an established mating paradigm, fetal microchimeric cells present in maternal mice were also tracked after parturition and stroke...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28637734/pregnancy-specific-stress-fetoplacental-haemodynamics-and-neonatal-outcomes-in-women-with-small-for-gestational-age-pregnancies-a-secondary-analysis-of-the-multicentre-prospective-observational-trial-to-optimise-paediatric-health-in-intrauterine-growth-restriction
#10
Terri A Levine, Ruth E Grunau, Ricardo Segurado, Sean Daly, Michael P Geary, Mairead M Kennelly, Keelin O'Donoghue, Alyson Hunter, John J Morrison, Gerard Burke, Patrick Dicker, Elizabeth C Tully, Fergal D Malone, Fiona A Alderdice, Fionnuala M McAuliffe
OBJECTIVES: To examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomes...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28635180/renal-vascularization-indexes-and-fetal-hemodynamics-in-fetuses-with-growth-restriction
#11
Giovana Farina Doro, Janaína Campos Senra, Agatha Sacramento Rodrigues, Seizo Miyadahira, Renata Lopes Ribeiro, Rossana Pulcinelli Vieira, Lisandra Stein Bernardes
OBJECTIVE: To identify the correlation between the renal vascularization index (VI), the flow index (FI) and the vascularization and flow index (VFI) and placental and fetal hemodynamics in fetuses with growth restriction. METHOD: Bidimensional ultrasound and three-dimensional power Doppler with the VOCAL technique were used to determine the renal vascular indexes and fetal and placental hemodynamics in fetuses below the 10(th) percentile for fetal weight. Partial correlation analysis (controlled for renal depth and gestational age) was performed...
June 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28611933/monochorionic-triamniotic-triplet-pregnancy-complicated-by-twin-reversed-arterial-perfusion-sequence-case-report-and-literature-review
#12
Pingshan Pan, Guoyang Luo, Lu Tang, Jeanne D Rolle, Yuqin Qin, Quan Zeng, Jiangting Wei, Yuanfang Chen, Hongwei Wei
Background  Monochorionic-triamniotic pregnancies are rare and fraught with complications. Case  A case of monochorionic-triamniotic triplet pregnancy complicated by twin reversed arterial perfusion (TRAP) sequence is presented. The patient declined termination or selective fetal reduction. Triplet C was acardiac. At 24 weeks, triplet B developed polyhydramnios. At 30 weeks, polyhydramnios was seen in all three amniotic sacs, but without signs of fetal hydrops and with normal Doppler velocimetry measurements in the umbilical artery, middle cerebral artery, and ductus arteriosus of triplets A and B...
April 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28591361/doppler-velocimetry-in-fetal-rats-exposed-to-enoxaparin-and-unfractionated-heparin-ufh-during-pregnancy
#13
Flavio Renato de Almeida Senefonte, Ricardo Dutra Aydos, Vanessa Marcon de Oliveira, Marco Antonio Costa Bósio, Ernesto Antonio Figueiró-Filho
Purpose: To evaluate the effects of enoxaparin and unfractionated heparin (UFH) administered in prophylactic and therapeutic doses on fetal vessels in healthy pregnant Wistar rats, according to Doppler velocimetry measurements. Methods: Fifty animals were assigned to one of five groups: controls (saline), prophylactic and therapeutic enoxaparin (1 and 2 mg/kg/day, respectively), and prophylactic and therapeutic UFH (72 and 400 UI/kg/day, respectively). Uterine horns were examined by ultrasound for identification of live fetuses...
May 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28571031/perimortem-demonstration-and-treatment-of-recipient-to-donor-transfusion-in-monochorionic-diamniotic-twin-gestation
#14
Jessica Parrott, Tricia Schwartz, Tracy Cowles, Marium Holland, Carl P Weiner
Twin-twin transfusion syndrome is a complication of monochorionic-diamniotic placentation. Should one twin die, ≈30% of co-twins will also die, and if they survive, ≈30% experience severe morbidity rates, each believed secondary to hemorrhage of the co-twin into the deceased twin. We report apparently the first ultrasound-documented case of perimortem hemorrhage in twin-twin transfusion syndrome and its treatment by emergent ultrasound-guided percutaneous cord occlusion followed by percutaneous fetal intravascular transfusion...
June 2, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28559076/prenatal-diagnosis-and-multimodal-neonatal-treatment-of-a-rare-pial-arteriovenous-fistula-case-report-and-review-of-the-literature
#15
Alessandro Pedicelli, Marta Iacobucci, Paolo Frassanito, Emilio Lozupone, Gabriele Masselli, Concezio Di Rocco, Cesare Colosimo
BACKGROUND: Intracranial pial arteriovenous fistulas (PAVFs) are direct communications between the arterial and venous system of the brain, with the characteristic absence of a plexiform nidus, as seen in the classic cerebral arteriovenous malformations. These vascular malformations, usually occurring in the pediatric population, very rarely are diagnosed in utero, because of a lack of understanding of the condition and because they may be hard to visualize. CASE DESCRIPTION: We report a rare case of a mass-effect PAVF diagnosed with fetal magnetic resonance imaging, involving the right cerebral hemisphere, fed by a pericallosal artery and associated with a giant venous dilatation...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28556937/abnormal-fetal-findings-associated-with-a-global-sphericity-index-of-the-4-chamber-view-below-the-5th-centile
#16
Greggory R DeVore, Gary Satou, Mark Sklansky
OBJECTIVES: The purpose of this study was to evaluate the global sphericity index (GSI) of the 4-chamber view and correlate the results with abnormal ultrasound findings. METHODS: The epicardial end-diastolic basal-apical length (BAL) and transverse length (TL) of the 4-chamber view were measured to compute the GSI (BAL/TL) in 200 control fetuses between 20 and 40 weeks' gestation. Three hundred study fetuses were prospectively examined between 17 and 39 weeks' gestation...
May 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28554529/maternal-alcohol-exposure-during-mid-pregnancy-dilates-fetal-cerebral-arteries-via-endocannabinoid-receptors
#17
Olga Seleverstov, Ana Tobiasz, J Scott Jackson, Ryan Sullivan, Dejian Ma, J Pierce Sullivan, Steven Davison, Yada Akkhawattanangkul, Danielle L Tate, Terry Costello, Stacey Barnett, Wei Li, Giancarlo Mari, Alex M Dopico, Anna N Bukiya
Prenatal alcohol exposure often results in fetal alcohol syndrome and fetal alcohol spectrum disorders. Mechanisms of fetal brain damage by alcohol remain unclear. We used baboons (Papio spp.) to study alcohol-driven changes in the fetal cerebral artery endocannabinoid system. Pregnant baboons were subjected to binge alcohol exposure via gastric infusion three times during a period equivalent to the second trimester of human pregnancy. A control group was infused with orange-flavored drink that was isocaloric to the alcohol-containing solution...
June 2017: Alcohol
https://www.readbyqxmd.com/read/28550175/chronic-hypoxia-attenuates-the-vasodilator-efficacy-of-protein-kinase-g-in-fetal-and-adult-ovine-cerebral-arteries
#18
Richard B Thorpe, Margaret C Hubbell, Jinjutha Silpanisong, James M Williams, William J Pearce
Long-term hypoxia (LTH) attenuates nitric oxide (NO) induced vasorelaxation in ovine middle cerebral arteries. Because cGMP-dependent protein kinase (PKG) is an important mediator of NO signaling in vascular smooth muscle, we tested the hypothesis that LTH diminishes the ability of PKG to interact with target proteins and cause vasorelaxation. Prominent among proteins that regulate vascular tone is the large conductance calcium-sensitive potassium (BK) channel, which is a substrate for PKG and is responsive to phosphorylation on multiple serine/threonine residues...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28546663/comparison-of-outcome-of-normal-and-high-risk-pregnancies-based-upon-cerebroplacental-ratio-assessed-by-doppler-studies
#19
Anita Kant, Namrata Seth, Deepti Rastogi
OBJECTIVES: To evaluate the cerebroplacental ratio which is the ratio of pulsatility index of fetal middle cerebral and umbilical arteries, in normal and high-risk pregnancies during 30-36 weeks of gestation. METHODS: In this study, we included 70 patients, who were scanned for Doppler parameters of Middle cerebral artery and Umbilical artery pulsatility index ratio of fetus, between 30 and 36 weeks, and then were followed till delivery. Thirty-five patients with normal pregnancy and 35 patients with high-risk pregnancy were included...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28436166/perinatal-loss-at-term-the-role-of-uteroplacental-and-fetal-doppler-assessment
#20
Caitriona Monaghan, Julia Binder, Baskaran Thilaganathan, José Morales-Roselló, Asma Khalil
OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
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