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https://www.readbyqxmd.com/read/27926890/physical-activity-exercise-and-diabetes-a-position-statement-of-the-american-diabetes-association
#1
REVIEW
Sheri R Colberg, Ronald J Sigal, Jane E Yardley, Michael C Riddell, David W Dunstan, Paddy C Dempsey, Edward S Horton, Kristin Castorino, Deborah F Tate
No abstract text is available yet for this article.
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27926732/electric-field-stimulated-protein-mechanics
#2
Doeke R Hekstra, K Ian White, Michael A Socolich, Robert W Henning, Vukica Šrajer, Rama Ranganathan
The internal mechanics of proteins-the coordinated motions of amino acids and the pattern of forces constraining these motions-connects protein structure to function. Here we describe a new method combining the application of strong electric field pulses to protein crystals with time-resolved X-ray crystallography to observe conformational changes in spatial and temporal detail. Using a human PDZ domain (LNX2(PDZ2)) as a model system, we show that protein crystals tolerate electric field pulses strong enough to drive concerted motions on the sub-microsecond timescale...
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27926682/clinical-outcomes-of-nonunions-of-hindfoot-and-ankle-fusions
#3
Fabian Krause, Alastair S E Younger, Judith F Baumhauer, Timothy R Daniels, Mark Glazebrook, Peter T Evangelista, Michael S Pinzur, Gowreeson Thevendran, Rafe M J Donahue, Christopher W DiGiovanni
BACKGROUND: While nonunion after foot and ankle fusion surgery has been associated with poor outcomes, we are not aware of any longitudinal study on this subject. Thus, we prospectively evaluated the impact of nonunion on clinical outcomes of foot and ankle fusions and identified potential risk factors for nonunion after these procedures. METHODS: Using data from a randomized clinical trial on recombinant human platelet-derived growth factor-BB (rhPDGF-BB; Augment Bone Graft, BioMimetic Therapeutics), union was defined either by assessment of computed tomography (CT) scans at 24 weeks by a reviewer blinded to the type of treatment or by the surgeon's composite assessment of clinical and radiographic findings at 52 weeks and CT findings at 24 or 36 weeks...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27926435/brain-correlates-of-the-intrinsic-subjective-cost-of-effort-in-sedentary-volunteers
#4
J Bernacer, I Martinez-Valbuena, M Martinez, N Pujol, E Luis, D Ramirez-Castillo, M A Pastor
One key aspect of motivation is the ability of agents to overcome excessive weighting of intrinsic subjective costs. This contribution aims to analyze the subjective cost of effort and assess its neural correlates in sedentary volunteers. We recruited a sample of 57 subjects who underwent a decision-making task using a prospective, moderate, and sustained physical effort as devaluating factor. Effort discounting followed a hyperbolic function, and individual discounting constants correlated with an indicator of sedentary lifestyle (global physical activity questionnaire; R=-0...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27925776/providers-and-administrators-perceptions-of-complementary-and-integrative-health-practices-across-the-veterans-health-administration
#5
Carol E Fletcher, Allison R Mitchinson, Erika Trumble, Daniel B Hinshaw, Jeffery A Dusek
OBJECTIVES: Use of complementary and integrative health (CIH) therapies is being promoted by the Veterans Health Administration (VA), but promotion may not equate to adoption. The purpose of this study was to explore whether perceptions regarding CIH at one VA medical center (VAMC) were similar to perceptions from a sample of other VAMCs. DESIGN: This article reports a subset of qualitative findings from a mixed-methods study. SETTING/PARTICIPANTS: Sites were recruited through a VA-wide CIH listserver...
December 7, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27925647/left-ventricular-function-assessed-by-one-point-carotid-wave-intensity-in-newly-diagnosed-untreated-hypertensive-patients
#6
Olga Vriz, Serena Favretto, Joanna Jaroch, Rychard Wojciech, Eduardo Bossone, Caterina Driussi, Francesco Antonini-Canterin, Paolo Palatini, Krystyna Loboz-Grudzien
OBJECTIVES: To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1 ) and late systole (W2 ). METHODS: A total of 145 untreated hypertensive patients were compared with 145 age- and sex-matched normotensive subjects. They underwent comprehensive echocardiography and WI analysis...
November 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925640/diagnosis-and-management-of-distal-clavicle-osteolysis
#7
Steven F DeFroda, Christopher Nacca, Gregory R Waryasz, Brett D Owens
Distal clavicle osteolysis is an uncommon condition that most commonly affects weight lifters and other athletes who perform repetitive overhead activity. Although this condition most commonly presents in young active men, it is becoming increasing more common in women with the rise in popularity of body building and extreme athletics. Distal clavicle osteolysis can be debilitating, especially in those with rigorous training regimens, preventing exercise because of pain with activities such as bench presses and chest flies...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27925419/are-fear-of-movement-self-efficacy-beliefs-and-fear-of-falling-associated-with-levels-of-disability-in-people-with-osteoarthritis-of-the-knee-a-cross-sectional-study
#8
Dave P Thompson, Katerina Moula, Steve R Woby
INTRODUCTION: Osteoarthritis of the knee (OAK) can result in significant disability and previous authors have suggested that cognitive and falls-related factors may be significant determinants of function. However, no previous studies have considered the relative influence of these factors when the effects of symptoms related to OAK are also considered. Additionally, it is plausible that falls-related factors exert a greater influence in patients who have previously fallen. METHODS: Fifty-eight patients were recruited from an outpatient physiotherapy department...
December 7, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27925326/navigating-physical-activity-engagement-following-a-diagnosis-of-cancer-a-qualitative-exploration
#9
C Cummins, N M Kayes, J Reeve, G Smith, R MacLeod, K M McPherson
This qualitative descriptive study explored cancer survivors' experiences of barriers and facilitators to undertaking physical activity to inform how services and professionals might offer better support. Purposive and theoretical sampling was used to recruit 25 people who were up to 5 years post-cancer diagnosis. Participants took part in face to face, semi-structured interviews, and transcripts were analysed using thematic analysis. The analysis identified five interrelated themes which represented cancer survivors' views: 1) You're on your own-a sense of abandonment post-treatment, and lack of sufficient and tailored information; 2) Dis-ease-disruption to self and identity, and a heightened awareness of physical self and fragility; 3) Becoming acclimatised-physical activity in the face of treatment-related side effects and residual impairment; 4) Importance of others-encouragement and support from health professionals, family and friends, and cancer-specific exercise groups; 5) Meanings people ascribed to physical activity-these were central and could help or hinder engagement...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27925033/new-carbohydrazide-derivatives-of-1h-pyrazolo-3-4-b-pyridine-and-trypanocidal-activity
#10
Raquel R S Salvador, Murilo L Bello, Igor R L Barreto, Maria A F Vera, Estela M F Muri, Sérgio DE Albuquerque, Luiza R S Dias
This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds were evaluated in order to identify the antiparasitic profile against trypomastigote and amastigote forms of Trypanosoma cruzi. The 4-carbohydrazide derivatives presented different profiles of activity. In the investigation of the chemical structure influence in the trypanocidal activity, the results indicated there are large lipophilicity and volume differences among these derivatives...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27924852/low-temperature-magneto-morphological-characterisation-of-coronene-and-the-resolution-of-previously-observed-unexplained-phenomena
#11
Jason Potticary, Rebecca Boston, Liana Vella-Zarb, Alex Few, Christopher Bell, Simon R Hall
The polyaromatic hydrocarbon coronene has been the molecule of choice for understanding the physical properties of graphene for over a decade. The modelling of the latter by the former was considered to be valid, as since it was first synthesised in 1932, the physical behaviour of coronene has been determined extremely accurately. We recently discovered however, an unforeseen polymorph of coronene, which exists as an enantiotrope with the previously observed crystal structure. Using low-temperature magnetisation and crystallographic measurements, we show here for the first time that the electronic and magnetic properties of coronene depend directly on the temperature at which it is observed, with hysteretic behaviour exhibited between 300 K and 100 K...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924724/delivery-systems-for-antimicrobial-peptides-and-proteins-towards-optimization-of-bioavailability-and-targeting
#12
Joana R Costa, Nádia C Silva, Bruno Sarmento, Manuela Pintado
Antimicrobial peptides (AMPs) and proteins are produced by a wide range of organisms as important elements of their defense mechanisms, forming a large number of antimicrobial compounds that can be used to treat several human infections. The potential for the use of AMPs and antimicrobial proteins in therapeutics is growing, but their application is often limited, due to their poor physical and/or chemical properties. In recent years, several drug delivery systems have been proposed to carry such molecules, in an attempt to overcome the difficulties regarding their properties...
December 7, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27924476/competitive-argonaute-based-rna-immunoprecipitation-for-investigation-of-transcriptomic-response-to-anti-mir
#13
John R Androsavich
Identification and validation of microRNA (miRNA) target genes is essential for gaining a better understanding of the many different functions miRNAs have in healthy and diseased cells. From a practical standpoint, validated target genes are also useful for monitoring pharmacological activity of developmental therapeutics that modulate miRNAs, such as anti-miRNA oligonucleotides (anti-miR). Here, we describe a method that uses changes in Argonaute 2-RNA immunoprecipitation in response to competition by anti-miR, titrated ex vivo, as physical evidence for target validation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27924283/effects-of-the-dietary-detoxification-program-on-serum-%C3%AE-glutamyltransferase-anthropometric-data-and-metabolic-biomarkers-in-adults
#14
Ju Ah Kim, Jin Young Kim, Seung Wan Kang
BACKGROUND: Persistent Organic Pollutants (POPs) are well-known environmental contaminants which are associated with chronic diseases. As foods are the major sources of human exposure to toxic pollutants, we developed an integrated dietary and education program to eliminate the chemical toxin throughout the human body. The present study evaluated effects of the dietary detoxification program on serum γ-glutamyltransferase (GGT), anthropometric data and metabolic biomarkers in adults...
September 2016: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/27923363/ankle-brachial-index-and-incident-diabetes-mellitus-the-atherosclerosis-risk-in-communities-aric-study
#15
Simin Hua, Laura R Loehr, Hirofumi Tanaka, Gerardo Heiss, Josef Coresh, Elizabeth Selvin, Kunihiro Matsushita
BACKGROUND: Individuals with peripheral artery disease (PAD) often have reduced physical activity, which may increase the future risk of diabetes mellitus. Although diabetes is a risk factor for PAD, whether low ankle-brachial index (ABI) predates diabetes has not been studied. METHODS: We examined the association of ABI with incident diabetes using Cox proportional hazards models in the ARIC Study. ABI was measured in 12,247 black and white participants without prevalent diabetes at baseline (1987-1989)...
December 7, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27923356/metric-properties-of-the-prescribe-healthy-life-screening-questionnaire-to-detect-healthy-behaviors-a-cross-sectional-pilot-study
#16
Paola Bully, Alvaro Sanchez, Gonzalo Grandes, Haizea Pombo, Ma Soledad Arietalenizbeaskoa, Veronica Arce, Catalina Martinez
BACKGROUND: Feasible and valid assessment of healthy behaviors is the first step for integrating health promotion in routine primary care. Therefore, the aim of this study was to develop and evaluate the validity and reliability of the "prescribe healthy life" screening questionnaire, a brief tool for detecting physical activity levels, consumption of fruit and vegetables, tobacco use and patients' compliance with minimal recommendations. METHODS: An observational cross-sectional study to determine the reliability and validity of this questionnaire by means of mixed (qualitative and quantitative) methods...
December 7, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27923183/the-distal-consequences-of-physical-and-emotional-neglect-in-emerging-adults-a-person-centered-multi-wave-longitudinal-study
#17
Joseph R Cohen, Suvarna V Menon, Ryan C Shorey, Vi Donna Le, Jeff R Temple
Despite being the most prevalent form of child maltreatment, the correlates and consequences of neglect are poorly understood, particularly during early adulthood. The present multi-wave, longitudinal study sought to address this gap in this literature by examining physical and emotional neglect in emerging adults in a diverse community sample. 580 adolescents (AgeMean=18.25; AgeSD=0.59; 58.3% female; 31% Hispanic, 28.9% Caucasian; 26.2% African-American; 13.9% other) completed self-report measures for child maltreatment at baseline, and measures for depression, posttraumatic stress disorder, generalized anxiety disorder, and substance use every year for three years...
December 3, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27923182/sociodemographic-lifestyle-and-psychosocial-determinants-of-hair-cortisol-in-a-south-london-community-sample
#18
Susanne Fischer, Roman Duncko, Stephani L Hatch, Andrew Papadopoulos, Laura Goodwin, Souci Frissa, Matthew Hotopf, Anthony J Cleare
OBJECTIVE: Hypothalamic-pituitary-adrenal (HPA) measures are crucial for research into stress and stress-related disorders. Most HPA measures fluctuate depending on diurnal rhythms and state confounders. Hair cortisol concentrations (HCC) are less susceptible to such fluctuations, but less is known about trait-like confounders. Using a community sample, we tested the relationship between HCC and a range of variables including demographic variables, hair treatment, and medication, as well as psychosocial variables, namely childhood trauma, critical life events, and depressive symptoms...
November 17, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27923111/evaluation-of-a-pilot-school-based-physical-activity-challenge-for-primary-students
#19
E Passmore, C Donato-Hunt, L Maher, R Havrlant, K Hennessey, A Milat, L Farrell
Issue addressed: Physical inactivity and sedentary behaviour among children are growing public health concerns. The Culture Health Communities Activity Challenge (hereafter known as the Challenge) is a school-based pedometer program in which classes compete to achieve the highest class average daily steps in an 8-week period. The Challenge aims to encourage physical activity in primary school students, with a focus on engaging Aboriginal students. The program was piloted in 15 classes in New South Wales in 2014...
December 2, 2016: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/27923101/secular-changes-in-physical-growth-and-obesity-among-southwestern-american-indian-children-over-four-decades
#20
P Vijayakumar, K M Wheelock, S Kobes, R G Nelson, R L Hanson, W C Knowler, M Sinha
BACKGROUND AND OBJECTIVES: Most studies describing childhood obesity in the United States are based on cross-sectional surveys and do not include substantial numbers of American Indians (AI). Secular trends in height and weight reflect general health status. This study describes weight trends and transitions among AI children over a 43-year period. METHODS: Anthropometric data were obtained from a prospective study conducted in a southwestern US AI population (1965 through 2007)...
December 6, 2016: Pediatric Obesity
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