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Michael Mulvey

Andrew Walkty, Philippe Lagace-Wiens, Heather Adam, Melanie Baxter, James Karlowsky, Michael R Mulvey, Melissa McCracken, George G Zhanel
Pseudomonas aeruginosa is an important nosocomial pathogen. The purpose of this study was to evaluate the antimicrobial susceptibility profile of P. aeruginosa clinical isolates obtained from inpatients and outpatients at hospitals across Canada from January 2008 to December 2015 (CANWARD Study). Susceptibility testing was performed using broth microdilution, as described by the Clinical and Laboratory Standards Institute. In total, 2906 P. aeruginosa isolates were evaluated. The percentage of isolates susceptible to common antipseudomonal antimicrobials was: colistin 94...
January 2017: Diagnostic Microbiology and Infectious Disease
David W Eyre, Dilrini De Silva, Kevin Cole, Joanna Peters, Michelle J Cole, Yonatan H Grad, Walter Demczuk, Irene Martin, Michael R Mulvey, Derrick W Crook, A Sarah Walker, Tim E A Peto, John Paul
Background: Tracking the spread of antimicrobial-resistant Neisseria gonorrhoeae is a major priority for national surveillance programmes. Objectives: We investigate whether WGS and simultaneous analysis of multiple resistance determinants can be used to predict antimicrobial susceptibilities to the level of MICs in N. gonorrhoeae. Methods: WGS was used to identify previously reported potential resistance determinants in 681 N. gonorrhoeae isolates, from England, the USA and Canada, with phenotypes for cefixime, penicillin, azithromycin, ciprofloxacin and tetracycline determined as part of national surveillance programmes...
March 10, 2017: Journal of Antimicrobial Chemotherapy
Chand S Mangat, Sadjia Bekal, Rebecca J Irwin, Michael R Mulvey
Virulence plasmids and antibiotic resistance plasmids are usually maintained separately in Salmonella spp., however we report an instance of a hybrid plasmid (pN13-01125) in Salmonella Dublin. The complete sequence of the 172,265 bp plasmid suggested that pN13-01125 is comprised of the previously described pSDVr and pSH696_135 plasmids and that the mechanism of hybridization likely involved IS6 (IS26) insertion sequence elements. The plasmid has a low conjugation frequency, confers resistance to six classes of antimicrobials, and contains a complete spv virulence operon...
March 20, 2017: Antimicrobial Agents and Chemotherapy
David A Boyd, Laura F Mataseje, Ross Davidson, Johannes A Delport, Jeff Fuller, Linda Hoang, Brigitte Lefebvre, Paul Levett, Diane L Roscoe, Barbara M Willey, Michael R Mulvey
Carbapenem-resistant Enterobacter cloacae complex isolates submitted to a reference laboratory from 2010 to 2015 were screened by PCR for seven common carbapenemase gene groups, namely, KPC, NDM, OXA-48, VIM, IMP, GES, and NMC-A/IMI. Nineteen of the submitted isolates (1.7%) were found to harbor Ambler class A blaNMC-A or blaIMI-type carbapenemases. All 19 isolates were resistant to at least one carbapenem but susceptible to aminoglycosides, trimethoprim-sulfamethoxazole, tigecycline, and ciprofloxacin. Most isolates (17/19) gave positive results with the Carba-NP test for phenotypic carbapenemase detection...
February 21, 2017: Antimicrobial Agents and Chemotherapy
Romaine Edirmanasinghe, Rita Finley, E Jane Parmley, Brent P Avery, Carolee Carson, Sadjia Bekal, George Golding, Michael R Mulvey
This study characterized cefoxitin-resistant and -susceptible Salmonella enterica serovar Heidelberg strains from humans, abattoir poultry, and retail poultry to assess the molecular relationships of isolates from these sources in Québec in 2012. Isolates were collected as part of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). All isolates were subjected to antimicrobial susceptibility testing, PCR for CMY-2, pulsed-field gel electrophoresis (PFGE), and whole-genome sequencing (WGS)...
April 2017: Antimicrobial Agents and Chemotherapy
Andrew Walkty, James A Karlowsky, Heather J Adam, Philippe Lagacé-Wiens, Melanie Baxter, Michael R Mulvey, Melissa McCracken, Susan M Poutanen, Diane Roscoe, George G Zhanel
BACKGROUND: Colistin is often used as an antimicrobial of last resort for the treatment of infections caused by multidrug-resistant gram-negative bacilli. In 2015, plasmid-mediated colistin resistance in Escherichia coli due to MCR-1 was described. The purpose of this study was to evaluate the frequency of colistin resistance among E. coli clinical isolates obtained from patients in Canadian hospitals as part of the Canadian Ward Surveillance Study (CANWARD) and to determine how often the mcr-1 gene is detected among the colistin-resistant subset...
October 2016: CMAJ Open
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system...
March 2017: Journal of Pain: Official Journal of the American Pain Society
Lucy Ziegler, Matthew Mulvey, Alison Blenkinsopp, Duncan Petty, Michael I Bennett
We linked UK cancer registry data with the corresponding electronic primary care medical records of 6080 patients who died of cancer over a 7-year period in a large United Kingdom city. We extracted all prescriptions for analgesics issued to each patient in the linked cohort during the 12 months before death and analysed the extent and duration of strong opioid treatment with clinical and patient characteristics. Strong opioids were prescribed for 48% of patients in the last year of life. Median interval between first prescription of a strong opioid and death was 9 weeks (interquartile range 3-23)...
November 2016: Pain
Amrita Bharat, Irene Martin, Walter Demczuk, Vanessa Allen, David Haldane, Linda Hoang, Michael R Mulvey
Neisseria gonorrhoeae strains with coresistance to the first-line antimicrobial treatments azithromycin and ceftriaxone are an emerging public health threat. Here, we present the complete genome sequences of three strains of N. gonorrhoeae, including one susceptible strain and two strains with coresistance to ceftriaxone and azithromycin.
2016: Genome Announcements
Laura F Mataseje, Kahina Abdesselam, Julie Vachon, Robyn Mitchel, Elizabeth Bryce, Diane Roscoe, David A Boyd, Joanne Embree, Kevin Katz, Pamela Kibsey, Andrew E Simor, Geoffrey Taylor, Nathalie Turgeon, Joanne Langley, Denise Gravel, Kanchana Amaratunga, Michael R Mulvey
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing globally; here we report on the investigation of CPE in Canada over a 5-year period. Participating acute care facilities across Canada submitted carbapenem-nonsusceptible Enterobacteriaceae from 1 January 2010 to 31 December 2014 to the National Microbiology Laboratory. All CPE were characterized by antimicrobial susceptibilities, pulsed-field gel electrophoresis, multilocus sequence typing, and plasmid restriction fragment length polymorphism analysis and had patient data collected using a standard questionnaire...
November 2016: Antimicrobial Agents and Chemotherapy
Simone Alidori, Robert L Bowman, Dmitry Yarilin, Yevgeniy Romin, Afsar Barlas, J Justin Mulvey, Sho Fujisawa, Ke Xu, Alessandro Ruggiero, Vladimir Riabov, Daniel L J Thorek, Hans David S Ulmert, Elliott J Brea, Katja Behling, Julia Kzhyshkowska, Katia Manova-Todorova, David A Scheinberg, Michael R McDevitt
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination...
2016: Nature Communications
Agatha N Jassem, Natalie Prystajecky, Fawziah Marra, Pamela Kibsey, Kennard Tan, Patricia Umlandt, Loretta Janz, Sylvie Champagne, Bruce Gamage, George R Golding, Michael R Mulvey, Bonnie Henry, Linda M N Hoang
Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008) and one Island Health hospital laboratory (2013) were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Chand S Mangat, David Boyd, Nicol Janecko, Sarah-Lynn Martz, Andrea Desruisseau, Michael Carpenter, Richard J Reid-Smith, Michael R Mulvey
No abstract text is available yet for this article.
May 2016: Antimicrobial Agents and Chemotherapy
Shelley W Peterson, Natalie C Knox, George R Golding, Shaun D Tyler, Andrea D Tyler, Philip Mabon, Joanne E Embree, Fiona Fleming, Sergio Fanella, Gary Van Domselaar, Michael R Mulvey, Morag R Graham
Whereas the infant gut microbiome is the subject of intense study, relatively little is known regarding the nares microbiome in newborns and during early life. This study aimed to survey the typical composition and diversity of human anterior nare microflora for developing infants over time, and to explore how these correlate to their primary caregivers. Single nare swabs were collected at five time points over a one-year period for each subject from infant-caregiver pairs. Our study comprised of 50 infants (recruited at 2 weeks, post delivery) and their 50 primary caregivers...
2016: PloS One
Maryam Falahpour, Wesley K Thompson, Angela E Abbott, Afrooz Jahedi, Mark E Mulvey, Michael Datko, Thomas T Liu, Ralph-Axel Müller
Autism spectrum disorder (ASD) is characterized by core sociocommunicative impairments. Atypical intrinsic functional connectivity (iFC) has been reported in numerous studies of ASD. A majority of findings has indicated long-distance underconnectivity. However, fMRI studies have thus far exclusively examined static iFC across several minutes of scanning. We examined temporal variability of iFC, using sliding window analyses in selected high-quality (low-motion) consortium datasets from 76 ASD and 76 matched typically developing (TD) participants (Study 1) and in-house data from 32 ASD and 32 TD participants...
June 2016: Brain Connectivity
Walter Demczuk, Irene Martin, Shelley Peterson, Amrita Bharat, Gary Van Domselaar, Morag Graham, Brigitte Lefebvre, Vanessa Allen, Linda Hoang, Greg Tyrrell, Greg Horsman, John Wylie, David Haldane, Chris Archibald, Tom Wong, Magnus Unemo, Michael R Mulvey
The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins and azithromycin (AZM) resistance (AZM(r)) represents a public health threat of untreatable gonorrhea infections. Genomic epidemiology through whole-genome sequencing was used to describe the emergence, dissemination, and spread of AZM(r) strains. The genomes of 213 AZM(r) and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages...
May 2016: Journal of Clinical Microbiology
Camille-Ann Thoms-Rodriguez, Tony Mazzulli, Nicole Christian, Barbara M Willey, David A Boyd, Laura F Mataseje, Michael R Mulvey, Celia D C Christie, Alison M Nicholson
INTRODUCTION: The global dissemination of the New Delhi metallo-beta-lactamase (NDM) gene among certain strains of bacteria has serious implications since the infections caused by such organisms pose a therapeutic challenge. Although the NDM gene has been detected in various parts of the world, this is the first report of its detection in the English-speaking Caribbean. The NDM producing Klebsiella pneumoniae was isolated from an Indian patient who had recently relocated to Jamaica. METHODOLOGY: Identification and susceptibility testing of the K...
February 28, 2016: Journal of Infection in Developing Countries
Anish B Bhatt, Claire K Mulvey, Atif N Qasim, Jayamohan V Nair, Michael R Rickels, Stuart B Prenner, Nayyar Iqbal, Muredach P Reilly
BACKGROUND: We investigated the association of electrocardiographic (ECG) abnormalities with markers of insulin resistance and pancreatic beta-cell dysfunction in a cross-sectional study of type 2 diabetes patients. METHODS: Electrocardiographic criteria were evaluated in the Penn Diabetes Heart Study participants (n = 1671; 64% male; 61% Caucasian), including a sub-sample (n = 710) that underwent oral glucose tolerance testing. The Matsuda Insulin Sensitivity Index and homeostasis model assessment of insulin resistance (HOMA-IR) estimated insulin sensitivity; Insulinogenic Index and homeostasis model assessment of beta-cell function assessed beta-cell function...
October 2016: Diabetes/metabolism Research and Reviews
Chand S Mangat, David Boyd, Nicol Janecko, Sarah-Lynn Martz, Andrea Desruisseau, Michael Carpenter, Richard J Reid-Smith, Michael R Mulvey
One of the core goals of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) is to monitor major meat commodities for antimicrobial resistance. Targeted studies with methodologies based on core surveillance protocols are used to examine other foods, e.g., seafood, for antimicrobial resistance to detect resistances of concern to public health. Here we report the discovery of a novel Ambler class A carbapenemase that was identified in a nontoxigenic strain of Vibrio cholerae (N14-02106) isolated from shrimp that was sold for human consumption in Canada...
January 11, 2016: Antimicrobial Agents and Chemotherapy
Andrew E Simor, Linda Pelude, George Golding, Rachel Fernandes, Elizabeth Bryce, Charles Frenette, Denise Gravel, Kevin Katz, Allison McGeer, Michael R Mulvey, Stephanie Smith, Karl Weiss
BACKGROUND Bloodstream infection (BSI) due to methicillin-resistant Staphylococcus aureus (MRSA) is associated with considerable morbidity and mortality. OBJECTIVE To determine the incidence of MRSA BSI in Canadian hospitals and to identify variables associated with increased mortality. METHODS Prospective surveillance for MRSA BSI conducted in 53 Canadian hospitals from January 1, 2008, through December 31, 2012. Thirty-day all-cause mortality was determined, and logistic regression analysis was used to identify variables associated with mortality...
April 2016: Infection Control and Hospital Epidemiology
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