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Michael Mulvey

Lucy Ziegler, Matthew Mulvey, Alison Blenkinsopp, Duncan Petty, Michael I Bennett
We linked UK cancer registry data with the corresponding electronic primary care medical records of 6080 patients who died of cancer over a 7-year period in a large United Kingdom city. We extracted all prescriptions for analgesics issued to each patient in the linked cohort during the 12 months before death and analysed the extent and duration of strong opioid treatment with clinical and patient characteristics. Strong opioids were prescribed for 48% of patients in the last year of life. Median interval between first prescription of a strong opioid and death was 9 weeks (interquartile range 3-23)...
November 2016: Pain
Amrita Bharat, Irene Martin, Walter Demczuk, Vanessa Allen, David Haldane, Linda Hoang, Michael R Mulvey
Neisseria gonorrhoeae strains with coresistance to the first-line antimicrobial treatments azithromycin and ceftriaxone are an emerging public health threat. Here, we present the complete genome sequences of three strains of N. gonorrhoeae, including one susceptible strain and two strains with coresistance to ceftriaxone and azithromycin.
2016: Genome Announcements
Laura F Mataseje, Kahina Abdesselam, Julie Vachon, Robyn Mitchel, Elizabeth Bryce, Diane Roscoe, David A Boyd, Joanne Embree, Kevin Katz, Pamela Kibsey, Andrew E Simor, Geoffrey Taylor, Nathalie Turgeon, Joanne Langley, Denise Gravel, Kanchana Amaratunga, Michael R Mulvey
Carbapenemase producing Enterobacteriaceae (CPE) is increasing globally; here we report on the investigation of CPE in Canada over a five-year period. Participating acute care facilities across Canada submitted carbapenem non-susceptible Enterobacteriaceae from January 1 2010 to December 31 2014 to the National Microbiology Laboratory. All CPEs were characterized by antimicrobial susceptibilities, pulsed-field gel electrophoresis, multi-locus sequence typing and plasmid restriction fragment length polymorphism analysis and had patient data collected using a standard questionnaire...
September 6, 2016: Antimicrobial Agents and Chemotherapy
Simone Alidori, Robert L Bowman, Dmitry Yarilin, Yevgeniy Romin, Afsar Barlas, J Justin Mulvey, Sho Fujisawa, Ke Xu, Alessandro Ruggiero, Vladimir Riabov, Daniel L J Thorek, Hans David S Ulmert, Elliott J Brea, Katja Behling, Julia Kzhyshkowska, Katia Manova-Todorova, David A Scheinberg, Michael R McDevitt
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination...
2016: Nature Communications
Agatha N Jassem, Natalie Prystajecky, Fawziah Marra, Pamela Kibsey, Kennard Tan, Patricia Umlandt, Loretta Janz, Sylvie Champagne, Bruce Gamage, George R Golding, Michael R Mulvey, Bonnie Henry, Linda M N Hoang
Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008) and one Island Health hospital laboratory (2013) were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Chand S Mangat, David Boyd, Nicol Janecko, Sarah-Lynn Martz, Andrea Desruisseau, Michael Carpenter, Richard J Reid-Smith, Michael R Mulvey
No abstract text is available yet for this article.
May 2016: Antimicrobial Agents and Chemotherapy
Shelley W Peterson, Natalie C Knox, George R Golding, Shaun D Tyler, Andrea D Tyler, Philip Mabon, Joanne E Embree, Fiona Fleming, Sergio Fanella, Gary Van Domselaar, Michael R Mulvey, Morag R Graham
Whereas the infant gut microbiome is the subject of intense study, relatively little is known regarding the nares microbiome in newborns and during early life. This study aimed to survey the typical composition and diversity of human anterior nare microflora for developing infants over time, and to explore how these correlate to their primary caregivers. Single nare swabs were collected at five time points over a one-year period for each subject from infant-caregiver pairs. Our study comprised of 50 infants (recruited at 2 weeks, post delivery) and their 50 primary caregivers...
2016: PloS One
Maryam Falahpour, Wesley K Thompson, Angela E Abbott, Afrooz Jahedi, Mark E Mulvey, Michael Datko, Thomas T Liu, Ralph-Axel Müller
Autism spectrum disorder (ASD) is characterized by core sociocommunicative impairments. Atypical intrinsic functional connectivity (iFC) has been reported in numerous studies of ASD. A majority of findings has indicated long-distance underconnectivity. However, fMRI studies have thus far exclusively examined static iFC across several minutes of scanning. We examined temporal variability of iFC, using sliding window analyses in selected high-quality (low-motion) consortium datasets from 76 ASD and 76 matched typically developing (TD) participants (Study 1) and in-house data from 32 ASD and 32 TD participants...
June 2016: Brain Connectivity
Walter Demczuk, Irene Martin, Shelley Peterson, Amrita Bharat, Gary Van Domselaar, Morag Graham, Brigitte Lefebvre, Vanessa Allen, Linda Hoang, Greg Tyrrell, Greg Horsman, John Wylie, David Haldane, Chris Archibald, Tom Wong, Magnus Unemo, Michael R Mulvey
The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins and azithromycin (AZM) resistance (AZM(r)) represents a public health threat of untreatable gonorrhea infections. Genomic epidemiology through whole-genome sequencing was used to describe the emergence, dissemination, and spread of AZM(r) strains. The genomes of 213 AZM(r) and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages...
May 2016: Journal of Clinical Microbiology
Camille-Ann Thoms-Rodriguez, Tony Mazzulli, Nicole Christian, Barbara M Willey, David A Boyd, Laura F Mataseje, Michael R Mulvey, Celia D C Christie, Alison M Nicholson
INTRODUCTION: The global dissemination of the New Delhi metallo-beta-lactamase (NDM) gene among certain strains of bacteria has serious implications since the infections caused by such organisms pose a therapeutic challenge. Although the NDM gene has been detected in various parts of the world, this is the first report of its detection in the English-speaking Caribbean. The NDM producing Klebsiella pneumoniae was isolated from an Indian patient who had recently relocated to Jamaica. METHODOLOGY: Identification and susceptibility testing of the K...
February 2016: Journal of Infection in Developing Countries
Anish B Bhatt, Claire K Mulvey, Atif N Qasim, Jayamohan V Nair, Michael R Rickels, Stuart B Prenner, Nayyar Iqbal, Muredach P Reilly
BACKGROUND: We investigated the association of electrocardiographic (ECG) abnormalities with markers of insulin resistance and pancreatic beta-cell dysfunction in a cross-sectional study of type 2 diabetic patients. METHODS: ECG criteria were evaluated in the Penn Diabetes Heart Study (PDHS) participants (n = 1671; 64% male; 61% Caucasian), including a sub-sample (n = 710) that underwent oral glucose tolerance testing (OGTT). The Matsuda Insulin Sensitivity Index (MISI) and homeostasis model assessment of insulin resistance (HOMA-IR) estimated insulin sensitivity; Insulinogenic Index (IGI) and homeostasis model assessment of beta-cell function (HOMA-B) assessed beta-cell function...
February 18, 2016: Diabetes/metabolism Research and Reviews
Chand S Mangat, David Boyd, Nicol Janecko, Sarah-Lynn Martz, Andrea Desruisseau, Michael Carpenter, Richard J Reid-Smith, Michael R Mulvey
One of the core goals of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) is to monitor major meat commodities for antimicrobial resistance. Targeted studies with methodologies based on core surveillance protocols are used to examine other foods, e.g., seafood, for antimicrobial resistance to detect resistances of concern to public health. Here we report the discovery of a novel Ambler class A carbapenemase that was identified in a nontoxigenic strain of Vibrio cholerae (N14-02106) isolated from shrimp that was sold for human consumption in Canada...
March 2016: Antimicrobial Agents and Chemotherapy
Andrew E Simor, Linda Pelude, George Golding, Rachel Fernandes, Elizabeth Bryce, Charles Frenette, Denise Gravel, Kevin Katz, Allison McGeer, Michael R Mulvey, Stephanie Smith, Karl Weiss
BACKGROUND Bloodstream infection (BSI) due to methicillin-resistant Staphylococcus aureus (MRSA) is associated with considerable morbidity and mortality. OBJECTIVE To determine the incidence of MRSA BSI in Canadian hospitals and to identify variables associated with increased mortality. METHODS Prospective surveillance for MRSA BSI conducted in 53 Canadian hospitals from January 1, 2008, through December 31, 2012. Thirty-day all-cause mortality was determined, and logistic regression analysis was used to identify variables associated with mortality...
April 2016: Infection Control and Hospital Epidemiology
Geneviève Labbé, Romaine Edirmanasinghe, Kim Ziebell, John H E Nash, Sadjia Bekal, E Jane Parmley, Michael R Mulvey, Roger P Johnson
Isolates of Salmonella enterica subsp. enterica serovar Heidelberg are often associated with poultry products and may cause severe human illness. Here, we report the fully assembled genome and plasmid sequences of three S. Heidelberg strains with phage types 9, 29, and 41.
2016: Genome Announcements
Claudia F Martinez de la Peña, Leon De Masi, Shahista Nisa, George Mulvey, Jesse Tong, Michael S Donnenberg, Glen D Armstrong
UNLABELLED: Enteropathogenic Escherichia coli (EPEC) remains a significant cause of infant diarrheal illness and associated morbidity and mortality in developing countries. EPEC strains are characterized by their ability to colonize the small intestines of their hosts by a multistep program involving initial loose attachment to intestinal epithelial cells followed by an intimate adhesion phase. The initial loose interaction of typical EPEC with host intestinal cells is mediated by bundle-forming pili (BFP)...
March 2016: Journal of Bacteriology
Inna Sekirov, Matthew A Croxen, Corrinne Ng, Robert Azana, Yin Chang, Laura Mataseje, David Boyd, Chand Mangat, Benjamin Mack, Manal Tadros, Elizabeth Brodkin, Pamela Kibsey, Aleksandra Stefanovic, Sylvie Champagne, Michael R Mulvey, Linda M N Hoang
Carbapenemase-producing organisms (CPOs) are a serious emerging problem for health care facilities worldwide. Owing to their resistance to most antimicrobial therapies, CPOs are difficult to treat and pose a challenge for infection prevention and control. Since 2010, lab-based surveillance for CPOs and PCR-based testing were implemented in British Columbia (BC), Canada. A review of CPOs in BC from 2008 to March 2014 was done to characterize the resistance mechanisms and possible clonal strain transmission and to compare pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and plasmid restriction fragment length polymorphism (RFLP) as molecular typing tools...
February 2016: Journal of Clinical Microbiology
Deborah Brown, Matthew Mulvey, Lis Cordingley, Amir Rashid, Michael Horan, Neil Pendleton, Rosie Duncan, John McBeth
Multiple tender points are common in the population and, in studies of mid-life adults, are strongly associated with high levels of psychological distress. Whether this relationship occurs in older adults is unclear. This cross-sectional study investigated whether high levels of psychological distress would be associated with a high tender point count and whether the relationship would be moderated by age. Three thousand three hundred and seventy-nine individuals were mailed a questionnaire which included the Hospital Anxiety and Depression (HAD) scale, the Pain Catastrophising Scale (PCS), the Brief Illness Perception Questionnaire (Brief IPQ), and the Pittsburgh Sleep Quality Index (PSQI)...
March 2016: Archives of Gerontology and Geriatrics
Amrita Bharat, Irene Martin, George G Zhanel, Michael R Mulvey
Antimicrobial resistant Neisseria gonorrhoeae is a major concern to public health due to decreased susceptibility to frontline antimicrobials. To find agents that are active against N. gonorrhoeae, we tested antimicrobials alone or in combination by Etest gradient strips. The potencies (as assessed by minimum inhibitory concentrations) of twenty-five antimicrobials were evaluated against nine reference strains of N. gonorrhoeae (WHO F, G, K, L, M, N, O, P and ATCC 49226). Potency was greatest for netilmicin, quinupristin-dalfopristin, ceftriaxone, ertapenem and piperacillin-tazobactam...
March 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Nicole Le Saux, Denise Gravel, Michael Mulvey, Dorothy Moore, Joanne M Langley, Susan Richardson, Caroline Quach, Kelly Baekyung Choi, Mark Miller, Kevin Katz
Children with healthcare-associated Clostridium difficile infection were identified. The incidence increased from 3.2/10,000 patient days in 2007 to 5.2/10,000 patient days in 2011 (p < 0.001). Of 169 isolates, the most common North American Pulsed-Field (NAP) types were NAP4 (n = 43; (25.4%), and NAP1 (n = 25;14.8%) while 55 (32.6%) were non-assigned NAP types.
December 2015: Journal of the Pediatric Infectious Diseases Society
Hillary E Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J Quesenberry, Devasis Chatterjee
BACKGROUND: Extracellular vesicles (EVs) are secreted from many cells, carrying cargoes including proteins and nucleic acids. Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype. METHODS: EVs were isolated from HCT116 colon cancer cells, 1459 non-malignant colon fibroblast cells, and tumor and normal colon tissue from a patient sample...
2015: BMC Cancer
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