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https://www.readbyqxmd.com/read/29336450/lithium-diamidodihydridoaluminates-bimetallic-cooperativity-in-catalytic-hydroboration-and-metallation-applications
#1
Victoria A Pollard, Samantha A Orr, Ross McLellan, Alan R Kennedy, Eva Hevia, Robert E Mulvey
Cooperativity between the Li and Al centres is implicated in catalytic hydroboration reactions of aldehydes and ketones with pinacolborane via heteroleptic lithium diamidodihydridoaluminates. In addition to implementing hydroalumination, these versatile heteroleptic ates can also perform as amido bases as illustrated with an acidic triazole.
January 16, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29329177/a-comparison-of-real-time-polymerase-chain-reaction-assays-for-the-detection-of-antimicrobial-resistance-markers-and-sequence-typing-from-clinical-nucleic-acid-amplification-test-samples-and-matched-neisseria-gonorrhoeae-culture
#2
Shelley W Peterson, Irene Martin, Walter Demczuk, Linda Hoang, John Wylie, Brigitte Lefebvre, Annie-Claude Labbé, Prenilla Naidu, David Haldane, Michael R Mulvey
Real-time polymerase chain reaction (PCR) assays to detect antimicrobial resistance-associated mutations were tested on Neisseria gonorrhoeae-positive clinical samples with matched isolates. Of the nucleic acid amplification tests/cultures, 87.7% (64/73), 98.6% (72/73), and 98.4% (62/63) predicted cephalosporin, ciprofloxacin, and azithromycin susceptibilities, respectively. N. gonorrhoeae multiantigen sequence type was correctly predicted for 98.7% (79/80), and 13 of 58 N. gonorrhoeae-negative specimens showed false-positive results...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29328907/weaving-new-insights-for-the-genetic-regulation-of-human-cognitive-phenotypes
#3
Bernard Mulvey, Joseph D Dougherty
Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these variants are unclear. By weaving in strands of genomic data from developing human brains, de la Torre-Ubieta et al. tie disease-associated loci to functional enhancers, target genes, and putatively affected cell types.
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29311232/context-dependent-requirements-for-fimh-and-other-canonical-virulence-factors-in-gut-colonization-by-extraintestinal-pathogenic-escherichia-coli
#4
Colin W Russell, Brittany A Fleming, Courtney A Jost, Alexander Tran, Alan T Stenquist, Morgan A Wambaugh, Mary P Bronner, Matthew A Mulvey
Extraintestinal pathogenic Escherichia coli (ExPEC) act as commensals within the mammalian gut, but can induce pathology upon dissemination to other host environments such as the urinary tract and bloodstream. ExPEC genomes are likely shaped by evolutionary forces encountered within the gut where the bacteria spend much of their time, provoking the question of how their extraintestinal virulence traits arose. The principle of coincidental evolution, in which a gene that evolved in one niche happens to be advantageous in another, has been used to argue that ExPEC virulence factors originated in response to selective pressures within the gut ecosystem...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29236737/comparison-of-sequential-multiplex-pcr-sequetyping-and-whole-genome-sequencing-for-serotyping-of-streptococcus-pneumoniae
#5
Florian Mauffrey, Éric Fournier, Walter Demczuk, Irene Martin, Michael Mulvey, Christine Martineau, Simon Lévesque, Sadjia Bekal, Marc-Christian Domingo, Florence Doualla-Bell, Jean Longtin, Brigitte Lefebvre
Streptococcus pneumoniae is one of the major causes of pneumonia, meningitis and other pneumococcal infections in young children and elders. Determination of circulating S. pneumoniae serotypes is an essential service by public health laboratories for the monitoring of putative serotype replacement following the introduction of pneumococcal conjugate vaccines (PCVs) and of the efficacy of the immunization program. The Quellung method remains the gold standard for typing S. pneumoniae. Although this method is very effective, it is also costly, time consuming and not totally reliable due to its subjective nature...
2017: PloS One
https://www.readbyqxmd.com/read/29229015/risk-factors-for-acquisition-of-multidrug-resistant-escherichia-coli-and-development-of-community-acquired-urinary-tract-infections
#6
U V Ukah, M Glass, B Avery, D Daignault, M R Mulvey, R J Reid-Smith, E J Parmley, A Portt, P Boerlin, A R Manges
We examined risk factors associated with the intestinal acquisition of antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) and development of community-acquired urinary tract infection (UTI) in a case-control study of young women across Canada. A total of 399 women were recruited; 164 women had a UTI caused by E. coli resistant to ⩾1 antimicrobial classes and 98 had a UTI caused by E. coli resistant to ⩾3 antimicrobial classes. After adjustment for age, student health service (region of Canada) and either prior antibiotic use or UTI history, consumption of processed or ground chicken, cooked or raw shellfish, street foods and any organic fruit; as well as, contact with chickens, dogs and pet treats; and travel to Asia, were associated with an increased risk of UTI caused by antimicrobial resistant E...
December 12, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29221487/clinical-laboratory-verification-of-thyroglobulin-concentrations-in-the-presence-of-autoantibodies-to-thyroglobulin-comparison-of-eia-radioimmunoassay-and-lc-ms-ms-measurements-in-an-urban-hospital
#7
Sarah E Wheeler, Li Liu, Harry C Blair, Richard Sivak, Nancy Longo, Jeffery Tischler, Kathryn Mulvey, Octavia M Peck Palmer
OBJECTIVE: Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb). Radioimmunoassay (RIA) is less susceptible to TgAb interference and has been the standard-of-care test for TgAb positive patients. Recently developed liquid chromatography tandem mass spectrometry (LC-MS/MS) methods may eliminate TgAb interference. We assessed the performance of Tg measurements by EIA, RIA and LC-MS/MS to evaluate TgAb interference differences...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29191894/benzene-submits-to-main-group-power
#8
Robert Emmet Mulvey
No abstract text is available yet for this article.
December 1, 2017: Science
https://www.readbyqxmd.com/read/29172558/childhood-risk-factors-associated-with-adolescent-gun-carrying-among-black-and-white-males-an-examination-of-self-protection-social-influence-and-antisocial-propensity-explanations
#9
Jordan Beardslee, Meagan Docherty, Edward Mulvey, Carol Schubert, Dustin Pardini
Adolescent gun violence is a serious public health issue that disproportionately affects young Black males. Although it has been postulated that differential exposure to childhood risk factors might account for racial differences in adolescent gun carrying, no longitudinal studies have directly examined this issue. We examined whether childhood risk factors indexing neighborhood crime, peer delinquency, and conduct problems predicted the initiation of adolescent gun carrying among a community sample of Black and White boys...
November 27, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/29130384/characterising-the-growth-in-palliative-care-prescribing-2011-2015-analysis-of-national-medical-and-non-medical-activity
#10
Lucy Ziegler, Michael I Bennett, Matt Mulvey, Tim Hamilton, Alison Blenkinsopp
BACKGROUND: The role of non-medical prescribers working in palliative care has been expanding in recent years and prescribers report improvements in patient care, patient safety, better use of health professionals' skills and more flexible team working. Despite this, there is a lack of empirical evidence to demonstrate its clinical and economic impact, limiting our understanding of the future role of non-medical prescribers within a healthcare system serving an increasing number of people with palliative care needs...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29121284/neuropathic-pain-in-cancer-systematic-review-performance-of-screening-tools-and-analysis-of-symptom-profiles
#11
M R Mulvey, E G Boland, D Bouhassira, R Freynhagen, J Hardy, M J Hjermstad, S Mercadante, C Pérez, M I Bennett
Background: The objectives of this study were to evaluate the methodological quality of rigorous neuropathic pain assessment tools in applicable clinical studies, and determine the performance of screening tools for identifying neuropathic pain in patients with cancer. Methods: Systematic literature search identified studies reporting use of Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), Douleur Neuropathique en 4 (DN4) or painDETECT (PDQ) in cancer patients with a clinical diagnosis of neuropathic or not neuropathic pain...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29107648/corrigendum-to-european-contribution-to-the-study-of-ros-a-summary-of-the-findings-and-prospects-for-the-future-from-the-cost-action-bm1203-eu-ros-redox-biol-13-2017-94-162
#12
J Egea, I Fabregat, Y M Frapart, P Ghezzi, A Görlach, T Kietzmann, K Kubaichuk, U G Knaus, M G Lopez, G Olaso-Gonzalez, A Petry, R Schulz, J Vina, P Winyard, K Abbas, O S Ademowo, C B Afonso, I Andreadou, H Antelmann, F Antunes, M Aslan, M M Bachschmid, R M Barbosa, V Belousov, C Berndt, D Bernlohr, E Bertrán, A Bindoli, S P Bottari, P M Brito, G Carrara, A I Casas, A Chatzi, N Chondrogianni, M Conrad, M S Cooke, J G Costa, A Cuadrado, P My-Chan Dang, B De Smet, B Debelec-Butuner, I H K Dias, J D Dunn, A J Edson, M El Assar, J El-Benna, P Ferdinandy, A S Fernandes, K E Fladmark, U Förstermann, R Giniatullin, Z Giricz, A Görbe, H Griffiths, V Hampl, A Hanf, J Herget, P Hernansanz-Agustín, M Hillion, J Huang, S Ilikay, P Jansen-Dürr, V Jaquet, J A Joles, B Kalyanaraman, D Kaminskyy, M Karbaschi, M Kleanthous, L O Klotz, B Korac, K S Korkmaz, R Koziel, D Kračun, K H Krause, V Křen, T Krieg, J Laranjinha, A Lazou, H Li, A Martínez-Ruiz, R Matsui, G J McBean, S P Meredith, J Messens, V Miguel, Y Mikhed, I Milisav, L Milković, A Miranda-Vizuete, M Mojović, M Monsalve, P A Mouthuy, J Mulvey, T Münzel, V Muzykantov, I T N Nguyen, M Oelze, N G Oliveira, C M Palmeira, N Papaevgeniou, A Pavićević, B Pedre, F Peyrot, M Phylactides, G G Pircalabioru, A R Pitt, H E Poulsen, I Prieto, M P Rigobello, N Robledinos-Antón, L Rodríguez-Mañas, A P Rolo, F Rousset, T Ruskovska, N Saraiva, S Sasson, K Schröder, K Semen, T Seredenina, A Shakirzyanova, G L Smith, T Soldati, B C Sousa, C M Spickett, A Stancic, M J Stasia, H Steinbrenner, V Stepanić, S Steven, K Tokatlidis, E Tuncay, B Turan, F Ursini, J Vacek, O Vajnerova, K Valentová, F Van Breusegem, L Varisli, E A Veal, A S Yalçın, O Yelisyeyeva, N Žarković, M Zatloukalová, J Zielonka, R M Touyz, A Papapetropoulos, T Grune, S Lamas, H H H W Schmidt, F Di Lisa, A Daiber
No abstract text is available yet for this article.
October 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/29094954/procedural-justice-legitimacy-beliefs-and-moral-disengagement-in-emerging-adulthood-explaining-continuity-and-desistance-in-the-moral-model-of-criminal-lifestyle-development
#13
Glenn D Walters
Research has shown that procedural justice reliably predicts future offending behavior, although there is some indication that this may be more a function of legitimacy beliefs than of procedural justice per se. The current study sought to explain continuity and desistance in the moral model of criminal lifestyle development by comparing legitimacy beliefs, procedural justice, and moral disengagement as initiators and mediators of pathways leading to early adult offending. It was hypothesized that low legitimacy beliefs but not perceived procedural (in)justice or moral disengagement would initiate, and that moral disengagement but not low legitimacy beliefs or procedural injustice would mediate, the effect of low legitimacy beliefs on subsequent offending behavior...
November 2, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/29070655/evaluation-of-modified-carbapenem-inactivation-method-for-detection-of-carbapenemases-in-pseudomonas-aeruginosa
#14
Luiz F Lisboa, LeeAnn Turnbull, David A Boyd, Michael R Mulvey, Tanis C Dingle
Detection of carbapenemases in Pseudomonas aeruginosa isolates is of utmost importance for preventing nosocomial transmission and detecting outbreaks.….
October 25, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29051323/epithelial-to-mesenchymal-transition-antagonizes-response-to-targeted-therapies-in-lung-cancer-by-suppressing-bim
#15
Kyung-A Song, Matthew J Niederst, Timothy L Lochmann, Aaron N Hata, Hidenori Kitai, Jungoh Ham, Konstantinos V Floros, Mark A Hicks, Haichuan Hu, Hillary E Mulvey, Yotam Drier, Daniel A R Heisey, Mark T Hughes, Neha U Patel, Elizabeth Lockerman, Angel R Garcia, Shawn Gillepsie, Hannah L Archibald, Maria Gomez-Caraballo, Tara J Nulton, Brad Windle, Zofia Piotrowska, Sinem E Sahingur, Shirley M Taylor, Mikhail G Dozmorov, Lecia V Sequist, Bradley E Bernstein, Hiromichi Ebi, Jeffrey A Engelman, Anthony C Faber
PURPOSE: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. EXPERIMENTAL DESIGN: We have developed several models of EMT-mediated resistance to EGFR inhibitors (EGFRi) in EGFR mutant lung cancers to evaluate a novel mechanism of EMT-mediated resistance. Results: We observed that mesenchymal EGFR mutant lung cancers are resistant to EGFRi-induced apoptosis via insufficient expression of BIM, preventing cell death despite potent suppression of oncogenic signaling following EGFRi treatment...
October 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28976457/revisiting-the-appendiceal-diameter-via-ultrasound-for-the-diagnosis-of-acute-appendicitis
#16
Henry P Chicaiza, Laurie Malia, Christine H Mulvey, Sharon R Smith
OBJECTIVES: This study aims to investigate the optimal outer appendiceal diameter via ultrasound for the diagnosis of acute appendicitis. METHODS: A retrospective chart review was conducted on patients (ages, 2-18 years) presenting to an urban pediatric emergency department between January 1, 2009 and December 31, 2010 with suspected acute appendicitis. Children were considered as having "suspected acute appendicitis" if they (1) presented with acute abdominal pain and had either a surgical consult or an abdominal ultrasound, or (2) presented or transferred with the stated suspicion of acute appendicitis...
October 2, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28957690/shared-ancestry-of-herpes-simplex-virus-1-strain-patton-with-recent-clinical-isolates-from-asia-and-with-strain-kos63
#17
Aldo Pourchet, Richard Copin, Matthew C Mulvey, Bo Shopsin, Ian Mohr, Angus C Wilson
Herpes simplex virus 1 (HSV-1) is a widespread pathogen that persists for life, replicating in surface tissues and establishing latency in peripheral ganglia. Increasingly, molecular studies of latency use cultured neuron models developed using recombinant viruses such as HSV-1 GFP-US11, a derivative of strain Patton expressing green fluorescent protein (GFP) fused to the viral US11 protein. Visible fluorescence follows viral DNA replication, providing a real time indicator of productive infection and reactivation...
December 2017: Virology
https://www.readbyqxmd.com/read/28940713/1-alkali-metal-2-alkyl-1-2-dihydropyridines-soluble-hydride-surrogates-for-catalytic-dehydrogenative-coupling-and-hydroboration-applications
#18
Ross McLellan, Alan R Kennedy, Robert E Mulvey, Samantha A Orr, Stuart D Robertson
Equipped with excellent hydrocarbon solubility, the lithium hydride surrogate 1-lithium-2-t-butyl-1,2-dihydropyridine (1tLi) functions as a precatalyst to convert Me₂NH·BH₃ to [NMe₂BH₂]₂ (89% conversion) under competitive conditions (2.5 mol%, 60h, 80°C, toluene solvent) to that of previously reported LiN(SiMe₃)₂. Sodium and potassium dihydropyridine congeners produce similar high yields of [NMe₂BH₂]₂ but require longer times. Switching the solvent to pyridine induces a remarkable change in the dehydrocoupling product ratio, with (NMe₂)₂BH favoured over [NMe₂BH₂]₂ (e...
September 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28938102/self-management-support-at-the-end-of-life-patients-carers-and-professionals-perspectives-on-managing-medicines
#19
N Campling, A Richardson, M Mulvey, M Bennett, B Johnston, S Latter
BACKGROUND: Pain is a frequently reported symptom by patients approaching the end of life and well-established that patients and carers hold fears relating to opioids, and experience side effects related to their use. The management of medicines is intrinsic to achieving effective pain relief. The concept of self-management support whilst well characterised in the context of chronic illness has not been elaborated with respect to end of life care. AIM: To identify patient, carer and professional views on the concept of self-management support at end of life, specifically in relation to analgesia and related medicines (for side-effect management) in order to describe, characterise and explain self-management support in this context...
September 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28890317/mitoneod-a-mitochondria-targeted-superoxide-probe
#20
Maria M Shchepinova, Andrew G Cairns, Tracy A Prime, Angela Logan, Andrew M James, Andrew R Hall, Sara Vidoni, Sabine Arndt, Stuart T Caldwell, Hiran A Prag, Victoria R Pell, Thomas Krieg, John F Mulvey, Pooja Yadav, James N Cobley, Thomas P Bright, Hans M Senn, Robert F Anderson, Michael P Murphy, Richard C Hartley
Mitochondrial superoxide (O2(⋅-)) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2(⋅-), but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions and DNA intercalation. To overcome these limitations, we developed a dual-purpose mitochondrial O2(⋅-) probe, MitoNeoD, which can assess O2(⋅-) changes in vivo by mass spectrometry and in vitro by fluorescence. MitoNeoD comprises a O2(⋅-)-sensitive reduced phenanthridinium moiety modified to prevent DNA intercalation, as well as a carbon-deuterium bond to enhance its selectivity for O2(⋅-) over non-specific oxidation, and a triphenylphosphonium lipophilic cation moiety leading to the rapid accumulation within mitochondria...
October 19, 2017: Cell Chemical Biology
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