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https://www.readbyqxmd.com/read/29770096/canadian-recommendations-for-laboratory-interpretation-of-multiple-or-extensive-drug-resistance-in-clinical-isolates-of-enterobacteriaceae-acinetobacter-species-and-pseudomonas-aeruginosa
#1
G J German, M Gilmour, G Tipples, H J Adam, H Almohri, J Bullard, T Dingle, D Farrell, G Girouard, D Haldane, L Hoang, P N Levett, R Melano, J Minion, R Needle, S N Patel, R Rennie, R C Reyes, J Longtin, M R Mulvey
The goal of this document was to provide Canadian laboratories with a framework for consistent reporting and monitoring of multidrug resistant organisms (MDRO) and extensively drug resistant organisms (XDRO) for common gram-negative pathogens. This is the final edition of the interim recommendations, which were modified after one year of broad consultative review. This edition represents a consensus of peer-reviewed information and was co-authored by the Canadian Public Health Laboratory Network and the Canadian Association of Clinical Microbiology and Infectious Diseases...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29755185/recidivism-in-a-sample-of-serious-adolescent-offenders
#2
Robert Brame, Edward P Mulvey, Carol A Schubert, Alex R Piquero
Objectives: A broad research literature in criminology documents key aspects of how criminal offending develops and changes over the life span. We contribute to this literature by showcasing methods that are useful for studying medium-term patterns of subsequent criminal justice system involvement among a sample of serious adolescent offenders making the transition to early adulthood. Methods: Our approach relies on 7 years of post-enrollment follow-up from the Pathways to Desistance Study...
March 2018: Journal of Quantitative Criminology
https://www.readbyqxmd.com/read/29709621/workforce-trends-and-analysis-of-selected-pediatric-subspecialties-in-the-united-states
#3
Mary E Rimsza, Holly S Ruch-Ross, Conrad J Clemens, William B Moskowitz, Holly J Mulvey
OBJECTIVE: To update pediatric subspecialty workforce data to support evidence-based legislation and public policy decisions by replicating the American Academy of Pediatrics' 1998 Future of Pediatric Education (FOPE II) workforce survey. STUDY DESIGN: A descriptive and comparative analysis of survey responses from 9,950 US pediatric subspecialists who completed an electronic survey. RESULTS: Pediatric subspecialists are working fewer hours and spending less of their time in direct patient care than they did in 1998 but the mean hours worked differs significantly by subspecialty...
April 27, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29697160/donor-influenced-structure-activity-correlations-in-stoichiometric-and-catalytic-reactions-of-lithium-monoamido-monohydrido-dialkylaluminates
#4
Robert E Mulvey, Jun Okuda, Lara E Lemmerz, Ross McLellan, Neil R Judge, Alan R Kennedy, Samantha A Orr, Marina Uzelac, Eva Hevia, Stuart D Robertson
A series of heteroleptic monoamido-monohydrido dialkyl-aluminate complexes of general formula [iBu2AlTMPHLi·donor] are synthesized and characterised in the solution and in the solid state. Applying these complexes in catalytic hydroboration reactions with representative aldehydes and ketones reveals that all are competent, however a definite donor substituent effect is discernible. The bifunctional nature of the complexes is also probed by assessing their performance in metallation of a triazole and phenylacetylene and addition across pyrazine...
April 26, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29686451/the-effect-of-elevated-a1c-on-immediate-postoperative-complications-a-prospective-observational-study
#5
Pinxia Chen, Katherine K Hallock, Christie L Mulvey, Arthur S Berg, Verghese T Cherian
IN BRIEF This study examined whether elevated A1C in patients with diabetes is associated with a higher incidence of postoperative infections and other complications. Researchers followed 50 noncardiac surgical patients for 7 postoperative days. Half of the patients had an A1C <7% and the other half had an A1C ≥7%. The two groups were otherwise comparable except that the higher-A1C group had significantly higher pre-induction and postoperative blood glucose levels, with wider variability in the first 24 hours after surgery...
April 2018: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29664766/utilization-of-nucleic-acid-amplification-testing-samples-for-antimicrobial-resistance-surveillance-in-remote-canadian-communities
#6
Michael R Mulvey, Irene Martin, Tom Wong
No abstract text is available yet for this article.
April 17, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29648943/who-skips-using-temperament-to-explain-differential-outcomes-of-a-motor-competence-intervention-for-preschoolers
#7
Sally A Taunton, Kelly Lynn Mulvey, Ali S Brian
PURPOSE: Although motor skill interventions often improve fundamental motor skills (FMS) during preschool, the extent of individual children's success in development of FMS still varies among children receiving the same intervention. Temperament is multifaceted and includes negative affect (high levels of frustration or anger), effortful control (focus, self-regulation, and concentration), and surgency (energy and activity level). Temperament often influences cognitive, social, and behavioral outcomes and may be a significant factor in the development of FMS...
April 12, 2018: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29603459/trans-metal-trapping-concealed-crossover-complexes-en-route-to-transmetallation
#8
Robert E Mulvey, Marina Uzelac
Defined as the transfer of ligands from one metal to another, transmetallation is a common reaction in organometallic chemistry. Its chemical celebrity stems from its role in important catalytic cycles of cross-coupling reactions such as those of Negishi, Sonogashira, Stille, or Suzuki. This article focuses on trans-metal-trapping (TMT), which could be construed as partially complete transmetallations. On mixing two distinct organometallic compounds, of for example lithium with aluminium or gallium, the two metals meet in a crossover co-complex, but the reaction ceases at that point and full transmetallation is not reached...
March 30, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29600261/total-knee-replacement-sizing-shoe-size-is-a-better-predictor-for-implant-size-than-body-height
#9
Sarah Trainor, Jamie Collins, Hannah Mulvey, Wolfgang Fitz
Background: Various sizes of implants need to be available during surgery. The purpose of this paper is to compare body height and shoe size with implant sizes in patients who underwent total knee replacement surgery to see which biomarker is a better predictor for preoperative planning to determine implant size. Methods: A total of 100 knees, belonging to 50 females and 50 males, were observed. Participants' body height and shoe size were collected and correlated to implant sizes of a current, frequently used, standard total knee replacement (TKR) implant...
March 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29595313/you-don-t-need-to-talk-to-throw-a-ball-children-s-inclusion-of-language-outgroup-members-in-behavioral-and-hypothetical-scenarios
#10
Kelly Lynn Mulvey, Corey Boswell, Kate Niehaus
To investigate children's inclusion of language-outgroup members, English-speaking children (8-9 years and 10-11 years of age, N = 57) made inclusion decisions while playing a simulated ball-tossing game, Cyberball, and while evaluating hypothetical scenarios involving language-outgroup members who wanted to play with their group. In the Cyberball game, the group norm was to exclude non-English-speaking peers, and participant tosses to a language-outgroup member (i.e., Spanish, Chinese, or Arabic speaking) were coded as a measure of behavioral inclusion...
March 29, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29588053/gun-and-non-gun-related-violence-exposure-and-risk-for-subsequent-gun-carrying-among-male-juvenile-offenders
#11
Jordan Beardslee, Edward Mulvey, Carol Schubert, Paul Allison, Arynn Infante, Dustin Pardini
OBJECTIVE: Although studies have found that youth exposed to violence are more likely to carry guns than non-exposed youth, this association could be due to common causal factors or other pre-existing differences between individuals. In this study, within-individual change models were used to determine whether juvenile offenders exhibit an increased propensity to carry a firearm after being exposed to gun violence and/or non-gun violence. The advantage of this approach is all time-invariant factors are eliminated as potential confounders...
April 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29553335/cooperative-recognition-of-internationally-disseminated-ceftriaxone-resistant-neisseria-gonorrhoeae-strain
#12
Monica M Lahra, Irene Martin, Walter Demczuk, Amy V Jennison, Ken-Ichi Lee, Shu-Ichi Nakayama, Brigitte Lefebvre, Jean Longtin, Alison Ward, Michael R Mulvey, Teodora Wi, Makoto Ohnishi, David Whiley
Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29509061/the-observed-longitudinal-relationship-between-future-orientation-and-substance-use-among-a-cohort-of-youth-with-serious-criminal-offenses
#13
Merrian Brooks, Elizabeth Miller, Kaleab Abebe, Edward Mulvey
BACKGROUND: Future orientation (FO), an essential construct in youth development, encompassing goals, expectations for life, and ability to plan for the future. This study uses a multidimensional measure of future orientation to assess the relationship between change in future orientation and change in substance use over time. METHODS: Data were from the Pathways to Desistence study. Justice involved youth (n = 1,354), ages 14 to 18 at time of recruitment, completed interviews every six months for three years...
March 6, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29465469/a-critical-appraisal-of-gabapentinoids-for-pain-in-cancer-patients
#14
Roberta I Jordan, Matthew R Mulvey, Michael I Bennett
PURPOSE OF REVIEW: Gabapentinoids are frequently used in the management of cancer pain. In recent Cochrane systematic reviews, although there was an abundance of evidence relating to non-cancer pain, only a few studies related to cancer pain. This review summarizes recent randomised controlled trials (RCTs) evaluating the use of gabapentinoids for tumour-related (as monotherapy or part of combination therapy) and treatment-related pain. RECENT FINDINGS: For tumour-related pain, ten out of thirteen studies showed statistically significant benefits in favour of gabapentinoids...
June 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29386620/overcoming-mcr-1-mediated-colistin-resistance-with-colistin-in-combination-with-other-antibiotics
#15
Craig R MacNair, Jonathan M Stokes, Lindsey A Carfrae, Aline A Fiebig-Comyn, Brian K Coombes, Michael R Mulvey, Eric D Brown
Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to colistin-induced lysis and bacterial cell death, but provides minimal protection from the ability of colistin to disrupt the Gram-negative outer membrane. Indeed, for colistin-resistant strains of Enterobacteriaceae expressing plasmid-borne mcr-1, clinically relevant concentrations of colistin potentiate the action of antibiotics that, by themselves, are not active against Gram-negative bacteria...
January 31, 2018: Nature Communications
https://www.readbyqxmd.com/read/29336450/lithium-diamidodihydridoaluminates-bimetallic-cooperativity-in-catalytic-hydroboration-and-metallation-applications
#16
Victoria A Pollard, Samantha A Orr, Ross McLellan, Alan R Kennedy, Eva Hevia, Robert E Mulvey
Cooperativity between the Li and Al centres is implicated in catalytic hydroboration reactions of aldehydes and ketones with pinacolborane via heteroleptic lithium diamidodihydridoaluminates. In addition to implementing hydroalumination, these versatile heteroleptic ates can also perform as amido bases as illustrated with an acidic triazole.
January 31, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29329177/a-comparison-of-real-time-polymerase-chain-reaction-assays-for-the-detection-of-antimicrobial-resistance-markers-and-sequence-typing-from-clinical-nucleic-acid-amplification-test-samples-and-matched-neisseria-gonorrhoeae-culture
#17
Shelley W Peterson, Irene Martin, Walter Demczuk, Linda Hoang, John Wylie, Brigitte Lefebvre, Annie-Claude Labbé, Prenilla Naidu, David Haldane, Michael R Mulvey
Real-time polymerase chain reaction (PCR) assays to detect antimicrobial resistance-associated mutations were tested on Neisseria gonorrhoeae-positive clinical samples with matched isolates. Of the nucleic acid amplification tests/cultures, 87.7% (64/73), 98.6% (72/73), and 98.4% (62/63) predicted cephalosporin, ciprofloxacin, and azithromycin susceptibilities, respectively. N. gonorrhoeae multiantigen sequence type was correctly predicted for 98.7% (79/80), and 13 of 58 N. gonorrhoeae-negative specimens showed false-positive results...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29328907/weaving-new-insights-for-the-genetic-regulation-of-human-cognitive-phenotypes
#18
Bernard Mulvey, Joseph D Dougherty
Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these variants are unclear. By weaving in strands of genomic data from developing human brains, de la Torre-Ubieta et al. tie disease-associated loci to functional enhancers, target genes, and putatively affected cell types.
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29311232/context-dependent-requirements-for-fimh-and-other-canonical-virulence-factors-in-gut-colonization-by-extraintestinal-pathogenic-escherichia-coli
#19
Colin W Russell, Brittany A Fleming, Courtney A Jost, Alexander Tran, Alan T Stenquist, Morgan A Wambaugh, Mary P Bronner, Matthew A Mulvey
Extraintestinal pathogenic Escherichia coli (ExPEC) acts as a commensal within the mammalian gut but can induce pathology upon dissemination to other host environments such as the urinary tract and bloodstream. ExPEC genomes are likely shaped by evolutionary forces encountered within the gut, where the bacteria spend much of their time, provoking the question of how their extraintestinal virulence traits arose. The principle of coincidental evolution, in which a gene that evolved in one niche happens to be advantageous in another, has been used to argue that ExPEC virulence factors originated in response to selective pressures within the gut ecosystem...
March 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29236737/comparison-of-sequential-multiplex-pcr-sequetyping-and-whole-genome-sequencing-for-serotyping-of-streptococcus-pneumoniae
#20
Florian Mauffrey, Éric Fournier, Walter Demczuk, Irene Martin, Michael Mulvey, Christine Martineau, Simon Lévesque, Sadjia Bekal, Marc-Christian Domingo, Florence Doualla-Bell, Jean Longtin, Brigitte Lefebvre
Streptococcus pneumoniae is one of the major causes of pneumonia, meningitis and other pneumococcal infections in young children and elders. Determination of circulating S. pneumoniae serotypes is an essential service by public health laboratories for the monitoring of putative serotype replacement following the introduction of pneumococcal conjugate vaccines (PCVs) and of the efficacy of the immunization program. The Quellung method remains the gold standard for typing S. pneumoniae. Although this method is very effective, it is also costly, time consuming and not totally reliable due to its subjective nature...
2017: PloS One
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