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https://www.readbyqxmd.com/read/28187108/complicated-case-presentation-management-of-pancreatic-neuroendocrine-tumors-in-multiple-endocrine-neoplasia-type-1
#1
Claire K Mulvey, Katherine Van Loon, Emily K Bergsland, Umesh Masharani, Eric K Nakakura
Multiple endocrine neoplasia type 1 (MEN1) is an inherited predisposition to tumors of the parathyroid glands, anterior pituitary, and pancreatic islet cells. In this review, we discuss the clinical case of a 45-year-old woman with MEN1 that was presented at the 2015 North American Neuroendocrine Tumor Society Symposium. In our review of this patient's complicated clinical course and subsequent operative management, we highlight controversies in the diagnosis and management of pancreatic neuroendocrine tumors in MEN1...
March 2017: Pancreas
https://www.readbyqxmd.com/read/28145549/contrasting-the-group-6-metal-metal-bonding-in-sodium-dichromate-ii-and-sodium-dimolybdate-ii-polymethyl-complexes-synthetic-x-ray-crystallographic-and-theoretical-studies
#2
Ross Campbell, Alan R Kennedy, Ross McLellan, Stuart D Robertson, Stephen Sproules, Robert E Mulvey
Extending the class of group 6 metal-metal bonded methylate compounds supported by alkali metal counter-ions, the first sodium octamethylmolybdate(ii) complex [(TMEDA)Na]4Mo2Me8 and heptamethylchromate(ii) relations [(donor)Na]3Cr2Me7 (donor is TMEDA or TMCDA) are reported. The former was made by treating [(Et2O)Li]4Mo2Me8 with four equivalents of NaOtBu/TMEDA in ether; whereas the latter resulted from introducing TMEDA or TMCDA to ether solutions of octamethyldichromate [(Et2O)Na]4Cr2Me8. X-ray crystallography revealed [(TMEDA)Na]4Mo2Me8 is dimeric with square pyramidal Mo centres [including a short Mo-Mo interaction of 2...
February 1, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28144650/dual-colorimetric-and-fluorogenic-probes-for-visualizing-tyrosine-phosphatase-activity
#3
Suvendu Biswas, Brandon S McCullough, Elena S Ma, Dollie LaJoie, Colin W Russell, D Garrett Brown, June L Round, Katharine S Ullman, Matthew A Mulvey, Amy M Barrios
Two resorufin-based substrates for protein tyrosine phosphatase (PTP) activity have been synthesized. These substrates provide sensitive fluorogenic readouts of PTP activity in vitro and in living cells at both acidic and neutral pH. In addition, the presence of the pathogenic bacteria Staphylococcus aureus was detected visually using a colorimetric readout.
February 1, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28137797/a-whole-genome-sequencing-approach-to-study-cefoxitin-resistant-salmonella-enterica-serovar-heidelberg-from-various-sources
#4
Romaine Edirmanasinghe, Rita Finley, E Jane Parmley, Brent P Avery, Carolee Carson, Sadjia Bekal, George Golding, Michael R Mulvey
This study characterized cefoxitin-resistant and susceptible Salmonella enterica serovar Heidelberg from human, abattoir poultry, and retail poultry to assess the molecular relationships of isolates from these sources in Québec in 2012. Isolates were collected as part of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). All isolates were subjected to antimicrobial susceptibility testing, polymerase chain reaction (PCR) for CMY-2, pulsed-field gel electrophoresis (PFGE), and whole genome sequencing (WGS)...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28135726/the-relationships-among-exposure-to-violence-psychological-distress-and-gun-carrying-among-male-adolescents-found-guilty-of-serious-legal-offenses-a-longitudinal-cohort-study
#5
Joan A Reid, Tara N Richards, Thomas A Loughran, Edward P Mulvey
Background: Gun violence and psychological problems are often conflated in public discourse on gun safety. However, few studies have empirically assessed the effect of exposure to violence when exploring the association between gun carrying and psychological distress. Objective: To examine the potential effect of exposure to violence on the associations between gun carrying and psychological distress among vulnerable adolescents. Design: Longitudinal cohort study...
January 31, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28122589/escherichia-coli-o78-isolated-from-septicemic-lambs-shows-high-pathogenicity-in-a-zebrafish-model
#6
Cecilie K Kjelstrup, Amelia E Barber, J Paul Norton, Matthew A Mulvey, Trine M L'Abée-Lund
The pathogenicity of Escherichia coli O78 strain K46, originally isolated from an outbreak of septicemia in neonatal lambs, was investigated in zebrafish embryo and murine models of infection. Its biofilm potential, cellulose production, and the expression of type 1 pili and curli fimbriae were measured by in vitro assays. The strain was highly pathogenic in the zebrafish embryo model of infection, where it killed all embryos within 24 h post inoculation (hpi) at doses as low as 1000 colony forming units. Zebrafish embryos inoculated with similar doses of commensal E...
January 25, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28119486/repeated-treatments-with-chitosan-in-combination-with-antibiotics-completely-eradicate-uropathogenic-escherichia-coli-from-infected-mouse-urinary-bladders
#7
Andreja Erman, Veronika Križan Hergouth, Matthew G Blango, Mojca Kerec Kos, Matthew A Mulvey, Peter Veranič
Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, colonize and invade the epithelial cells of the bladder urothelium. Infection of immature urothelial cells can result in the formation of persistent intracellular reservoirs that are refractory to antibiotic treatments. Previously, we defined a novel therapeutic strategy utilizing the bladder cell exfoliant chitosan to deplete UPEC reservoirs. However, though a single treatment of chitosan followed by ciprofloxacin administration had a marked effect on reducing UPEC titers within the bladder, this treatment failed to prevent relapsing bacteriuria...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28116983/complications-associated-with-mortality-after-head-and-neck-surgery
#8
Carolyn L Mulvey, Jason A Brant, Andrés M Bur, Jinbo Chen, John P Fischer, Steven B Cannady, Jason G Newman
Objective To determine which complications, as defined by the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database, correlate with 30-day mortality in surgery for malignancies of the head and neck. Study Design Retrospective review of prospectively collected national database. Setting NSQIP. Subjects and Methods NSQIP data from 2005 to 2014 were queried for ICD-9 codes head and neck malignancies. Multivariate logistic regression was used to examine the correlation of individual complications with 30-day mortality...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28090789/escalating-mental-health-care-in-pediatric-emergency-departments
#9
Steven C Rogers, Christine H Mulvey, Susan Divietro, Jesse Sturm
No abstract text is available yet for this article.
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28087946/invasion-of-host-cells-and-tissues-by-uropathogenic-bacteria
#10
Adam J Lewis, Amanda C Richards, Matthew A Mulvey
Within the mammalian urinary tract uropathogenic bacteria face many challenges, including the shearing flow of urine, numerous antibacterial molecules, the bactericidal effects of phagocytes, and a scarcity of nutrients. These problems may be circumvented in part by the ability of uropathogenic Escherichia coli and several other uropathogens to invade the epithelial cells that line the urinary tract. By entering host cells, uropathogens can gain access to additional nutrients and protection from both host defenses and antibiotic treatments...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28046940/su-f-r-03-classification-of-glioblastoma-multiforme-molecular-subtypes-using-three-dimensional-multi-modal-mr-imaging-features
#11
M Mulvey, S Muhyadeen, U Sinha
PURPOSE: Positive patient outcomes with the use of aggressive concurrent chemoradiotherapy have been shown for classical and mesenchymal glioblastoma multiformae (GBM) subtypes, while not having the same positive effect for patients with neural and proneural subtypes. Quantitative MR Imaging features from multimodal MRI have been recently explored for GBM subtype classification with some promising results. We have integrated 3D textural and moment invariant features to investigate if these will strengthen the association between glioblastoma MR image features and genomic markers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029297/capturing-high-value-cancer-care-in-the-wild
#12
Therese Marie Mulvey, Jeffrey Peppercorn
No abstract text is available yet for this article.
December 28, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28018876/frequency-of-mcr-1-mediated-colistin-resistance-among-escherichia-coli-clinical-isolates-obtained-from-patients-in-canadian-hospitals-canward-2008-2015
#13
Andrew Walkty, James A Karlowsky, Heather J Adam, Philippe Lagacé-Wiens, Melanie Baxter, Michael R Mulvey, Melissa McCracken, Susan M Poutanen, Diane Roscoe, George G Zhanel
BACKGROUND: Colistin is often used as an antimicrobial of last resort for the treatment of infections caused by multidrug-resistant gram-negative bacilli. In 2015, plasmid-mediated colistin resistance in Escherichia coli due to MCR-1 was described. The purpose of this study was to evaluate the frequency of colistin resistance among E. coli clinical isolates obtained from patients in Canadian hospitals as part of the Canadian Ward Surveillance Study (CANWARD) and to determine how often the mcr-1 gene is detected among the colistin-resistant subset...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28000994/lithium-dihydropyridine-dehydrogenation-catalysis-a-group%C3%A2-1-approach-to-the-cyclization-of-diamine-boranes
#14
Ross McLellan, Alan R Kennedy, Samantha A Orr, Stuart D Robertson, Robert E Mulvey
In reactions restricted previously to a ruthenium catalyst, a 1-lithium-2-alkyl-1,2-dihydropyridine complex is shown to be a competitive alternative dehydrogenation catalyst for the transformation of diamine boranes into cyclic 1,3,2-diazaborolidines, which can in turn be smoothly arylated in good yields. This study established the conditions and solvent dependence of the catalysis through NMR monitoring, with mechanistic insight provided by NMR (including DOSY) experiments and X-ray crystallographic studies of several model lithio intermediates...
December 21, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27989537/delayed-cardiac-tamponade-a-rare-but-life-threatening-complication-of-catheter-ablation
#15
Elizabeth Yetter, Jared Brazg, Diane Del Valle, Laura Mulvey, Eitan Dickman
Delayed cardiac tamponade (DCT) is a rare and life-threatening complication of catheter ablation performed as a treatment of atrial fibrillation, with few cases described in the medical literature. We present the case of a 57year-old man presenting with DCT 61days following a catheter ablation procedure. To the best of our knowledge, this is the most delayed case of cardiac tamponade (CT) following catheter ablation described in the literature. We also discuss the importance of point of care ultrasound (POCUS) in the diagnosis and treatment of CT...
November 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27890457/the-role-of-whole-genome-sequencing-in-antimicrobial-susceptibility-testing-of-bacteria-report-from-the-eucast-subcommittee
#16
REVIEW
M J Ellington, O Ekelund, F M Aarestrup, R Canton, M Doumith, C Giske, H Grundman, H Hasman, M T G Holden, K L Hopkins, J Iredell, G Kahlmeter, C U Köser, A MacGowan, D Mevius, M Mulvey, T Naas, T Peto, J-M Rolain, Ø Samuelsen, N Woodford
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility from a single assay. The European Committee on Antimicrobial Susceptibility Testing established a subcommittee to review the current development status of WGS for bacterial antimicrobial susceptibility testing (AST). The published evidence for using WGS as a tool to infer antimicrobial susceptibility accurately is currently either poor or non-existent and the evidence / knowledge base requires significant expansion. The primary comparators for assessing genotypic-phenotypic concordance from WGS data should be changed to epidemiological cut-off values in order to improve differentiation of wild-type from non-wild-type isolates (harbouring an acquired resistance)...
January 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27884691/aapt-diagnostic-criteria-for-chronic-cancer-pain-conditions
#17
REVIEW
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27820834/ccl2-ccr2-regulates-the-tumor-microenvironment-in-her-2-neu-driven-mammary-carcinomas-in-mice
#18
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization...
2016: PloS One
https://www.readbyqxmd.com/read/27737442/association-of-clinical-risk-factors-and-postoperative-complications-with-unplanned-hospital-readmission-after-head-and-neck-cancer-surgery
#19
Andrés M Bur, Jason A Brant, Carolyn L Mulvey, Elizabeth A Nicolli, Robert M Brody, John P Fischer, Steven B Cannady, Jason G Newman
Importance: Unplanned hospital readmission is costly and in recent years has become a focus of health care legislation intended to reduce health care expenditures. Greater understanding of which perioperative complications are associated with hospital readmission after surgery for head and neck cancer is needed to reduce unplanned readmissions. Objective: To determine which clinical risk factors and complications are associated with 30-day unplanned readmission after surgery for malignant neoplasms of the head and neck...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27722632/revealing-the-remarkable-structural-diversity-of-the-alkali-metal-transfer-agents-of-the-trans-calix-2-benzene-2-pyrrolide-ligand
#20
M Ángeles Fuentes, Antonio J Martínez-Martínez, Alan R Kennedy, Robert E Mulvey
Excellent reagents for transferring their heterocalix[4]arene ligand to f-block organometallic complexes, lithium, sodium and potassium trans-calix[2]benzene[2]pyrrolides have been found to adopt a fascinating series of structures in their own right.
October 6, 2016: Chemical Communications: Chem Comm
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