keyword
https://read.qxmd.com/read/38534100/plant-phenolics-inhibit-focal-adhesion-kinase-and-suppress-host-cell-invasion-by-uropathogenic-escherichia-coli
#1
JOURNAL ARTICLE
Adam J Lewis, Amanda C Richards, Alejandra A Mendez, Bijaya K Dhakal, Tiffani A Jones, Jamie L Sundsbak, Danelle S Eto, Alexis A Rousek, Matthew A Mulvey
Traditional folk treatments for the prevention and management of urinary tract infections (UTIs) and other infectious diseases often include plants and plant extracts that are rich in phenolic compounds. These have been ascribed a variety of activities, including inhibition of bacterial interactions with host cells. Here, we tested a panel of four well-studied phenolic compounds-caffeic acid phenethyl ester (CAPE), resveratrol, catechin, and epigallocatechin gallate-for the effects on host cell adherence and invasion by uropathogenic Escherichia coli (UPEC)...
March 27, 2024: Infection and Immunity
https://read.qxmd.com/read/38526086/when-the-trojan-horse-is-unable-to-reach-inside-the-city-investigation-of-the-mechanism-of-resistance-behind-the-first-reported-cefiderocol-resistant-e-coli-in-canada
#2
JOURNAL ARTICLE
Kevin R Barker, Gabriel W Rebick, Ken Fakharuddin, Clayton MacDonald, Michael R Mulvey, Laura F Mataseje
Gram-negative metallo-β-lactamase-producing bacteria can be extremely problematic, especially when found to be extensively drug-resistant (XDR). Cefiderocol is a novel antimicrobial that has been shown to overcome most carbapenemases, with very rare resistance reported to date. Within our institution, two multidrug-resistant and one XDR strains were isolated from a patient who recently emigrated from India. Each isolate underwent whole-genome sequencing to resolve plasmids and determine phylogenetics, strain typing, and mechanisms of resistance...
March 25, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38524762/bacterial-diversity-and-chemical-ecology-of-natural-product-producing-bacteria-from-great-salt-lake-sediment
#3
JOURNAL ARTICLE
Elijah R Bring Horvath, William J Brazelton, Min Cheol Kim, Reiko Cullum, Matthew A Mulvey, William Fenical, Jaclyn M Winter
Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product-producing bacteria, which could be used as resources for the discovery of biologically active compounds...
January 2024: ISME Commun
https://read.qxmd.com/read/38516637/children-s-and-adolescents-evaluations-of-wealth-related-stem-inequality
#4
JOURNAL ARTICLE
Luke McGuire, Christina Marlow, Adam J Hoffman, Angelina Joy, Fidelia Law, Adam Hartstone-Rose, Adam Rutland, Mark Winterbottom, Frances Balkwill, Karen P Burns, Laurence Butler, Grace Fields, Kelly Lynn Mulvey
The fields of science, technology, engineering, and mathematics (STEM) are rife with inequalities and under-representation that have their roots in childhood. While researchers have focused on gender and race/ethnicity as two key dimensions of inequality, less attention has been paid to wealth. To this end, and drawing from the Social Reasoning Development approach, we examined children's and adolescents' perceptions of STEM ability and access to opportunities as a function of wealth, as well as their desire to rectify such inequalities...
February 2024: Social Development
https://read.qxmd.com/read/38491432/systematic-review-and-meta-analysis-of-physical-activity-interventions-to-increase-elementary-children-s-motor-competence-a-comprehensive-school-physical-activity-program-perspective
#5
JOURNAL ARTICLE
Jongho Moon, Collin A Webster, David F Stodden, Ali Brian, Kelly Lynn Mulvey, Michael Beets, Cate A Egan, Lori Irene Flick McIntosh, Christopher B Merica, Laura Russ
BACKGROUND: Regular participation in physical activity (PA) benefits children's health and well-being and protects against the development of unhealthy body weight. A key factor in children's PA participation is their motor competence (MC). The comprehensive school physical activity program (CSPAP) framework offers a way to classify existing PA interventions that have included children's MC development and understand the potential avenues for supporting children's MC. However, there have been no systematic reviews or meta-analyses of PA interventions and their effects on the MC of elementary school children (aged 5-12 years) from a CSPAP perspective...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38478445/use-of-parallel-explanatory-models-to-enhance-transparency-of-neural-network-configurations-for-cell-degradation-detection
#6
JOURNAL ARTICLE
David Mulvey, Chuan Heng Foh, Muhammad Ali Imran, Rahim Tafazolli
In a previous paper, we have shown that a recurrent neural network (RNN) can be used to detect cellular network radio signal degradations accurately. We unexpectedly found, though, that accuracy gains diminished as we added layers to the RNN. To investigate this, in this article, we build a parallel model to illuminate and understand the internal operation of neural networks (NNs), such as the RNN, which store their internal state to process sequential inputs. This model is widely applicable in that it can be used with any input domain where the inputs can be represented by a Gaussian mixture...
March 13, 2024: IEEE Transactions on Neural Networks and Learning Systems
https://read.qxmd.com/read/38464005/resistance-gene-association-and-inference-network-regain-a-bioinformatics-pipeline-for-assessing-probabilistic-co-occurrence-between-resistance-genes-in-bacterial-pathogens
#7
Elijah R Bring Horvath, Mathew G Stein, Matthew A Mulvey, Edgar J Hernandez, Jaclyn M Winter
The rampant rise of multidrug resistant (MDR) bacterial pathogens poses a severe health threat, necessitating innovative tools to unravel the complex genetic underpinnings of antimicrobial resistance. Despite significant strides in developing genomic tools for detecting resistance genes, a gap remains in analyzing organism-specific patterns of resistance gene co-occurrence. Addressing this deficiency, we developed the Resistance Gene Association and Inference Network (ReGAIN), a novel web-based and command line genomic platform that uses Bayesian network structure learning to identify and map resistance gene networks in bacterial pathogens...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38463902/antimicrobial-susceptibilities-of-neisseria-gonorrhoeae-in-canada-2021
#8
JOURNAL ARTICLE
Pamela Sawatzky, Brigitte Lefebvre, Mathew Diggle, Linda Hoang, Jason Wong, Samir Patel, Paul Van Caessele, Jessica Minion, Richard Garceau, Sarah Jeffrey, David Haldane, Lillian Lourenco, Genevieve Gravel, Michael Mulvey, Irene Martin
BACKGROUND: In Canada, gonorrhea is the second most prevalent bacterial sexually transmitted infection. The Gonococcal Antimicrobial Surveillance Programme (GASP - Canada), a passive surveillance system monitoring antimicrobial resistance in Neisseria gonorrhoeae in Canada since 1985, is the source for this summary of demographics, antimicrobial resistance and N. gonorrhoeae multi-antigen sequence typing (NG-MAST) of gonococcal isolates collected in Canada in 2021. METHODS: Provincial and territorial public health laboratories submitted N...
September 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38444368/white-american-transgender-adults-retrospective-reports-on-the-social-and-contextual-aspects-of-their-gender-identity-development
#9
JOURNAL ARTICLE
Emily Herry, S M Rodan, Madeline Martin, Mariam M Sanjak, Kelly Lynn Mulvey
A growing body of research has attended to the experiences of transgender and gender non-conforming (TGN) youth's gender identity development. However, practical and ethical concerns have impeded our ability to understand the experiences of TGN youth. Thus, the aim of this study was to utilize one-on-one semi-structured interviews to explore White American TGN adults' (N = 15) retrospective accounts of their gender identity development in childhood and adolescence. Findings demonstrate considerable heterogeneity in TGN adults' retrospective accounts of their gender identity development...
March 6, 2024: British Journal of Developmental Psychology
https://read.qxmd.com/read/38442904/can-chatgpt-answer-patient-questions-regarding-total-knee-arthroplasty
#10
JOURNAL ARTICLE
Aleksander P Mika, Hillary E Mulvey, Stephen M Engstrom, Gregory G Polkowski, J Ryan Martin, Jacob M Wilson
The internet has introduced many resources frequently accessed by patients prior to orthopaedic visits. Recently, Chat Generative Pre-Trained Transformer, an artificial intelligence-based chat application, has become publicly and freely available. The interface uses deep learning technology to mimic human interaction and provide convincing answers to questions posed by users. With its rapidly expanding usership, it is reasonable to assume that patients will soon use this technology for preoperative education...
March 5, 2024: Journal of Knee Surgery
https://read.qxmd.com/read/38418750/developmental-trajectories-of-adolescents-math-motivation-the-role-of-mindset-and-perceptions-of-informal-stem-learning-site-inclusivity
#11
JOURNAL ARTICLE
Emine Ozturk, Mengya Zhao, Adam J Hoffman, Angelina Joy, Christina S Marlow, Fidelia Law, Ashley R Deutsch, Channing J Mathews, Luke McGuire, Frances Balkwill, Karen Burns, Laurence Butler, Marc Drews, Grace Fields, Hannah Smith, Mark Winterbottom, Adam Rutland, Adam Hartstone-Rose, Kelly Lynn Mulvey
Motivation is a key factor in engagement, achievement, and career choices in science, technology, engineering, and mathematics (STEM). While existing research has focused on student motivation toward math in formal school programs, new work is needed that focuses on motivation for those involved in informal STEM programs. Specifically, the role of math mindset and perceived inclusivity of informal STEM sites (to those of varying gender and ethnic backgrounds) on longitudinal trajectories of adolescents' math motivation has not been explored...
February 28, 2024: Journal of Youth and Adolescence
https://read.qxmd.com/read/38414535/real-time-quantitative-reverse-transcription-polymerase-chain-reaction-detection-of-sars-cov-2-delta-variant-in-canadian-wastewater
#12
JOURNAL ARTICLE
Shelley Peterson, Jade Daigle, Codey Dueck, Audra Nagasawa, Michael Mulvey, Chand S Mangat
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern are associated with increased infectivity, severity, and mortality of coronavirus disease 2019 (COVID-19) and have been increasingly detected in clinical and wastewater surveillance in Canada and internationally. In this study, we present a real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay for detection of the N gene D377Y mutation associated with the SARS-CoV-2 Delta variant in wastewater...
May 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38384939/white-american-students-recognition-of-racial-microaggressions-in-higher-education
#13
JOURNAL ARTICLE
Allegra J Midgette, Kelly Lynn Mulvey
Racial microaggressions often occur in U.S. higher education. However, less is known about how White American students reason about their evaluations of racial microaggressions. The current study investigated how 213 White college students (54.46% cisgender women) attending a PWI in the Southeast U.S. in the Fall of 2019 justified their evaluations of the acceptability of racial microaggressions presented in vignettes. Following Social Domain Theory, to assess participants' social reasoning, we conducted quantitative content analysis of participants' open-ended justifications for their evaluations...
February 2024: Journal of Diversity in Higher Education
https://read.qxmd.com/read/38375093/application-and-accuracy-of-the-eapc-iasp-diagnostic-algorithm-for-neuropathic-cancer-pain-and-quantitative-sensory-testing-profile-in-patients-with-pain-due-to-cancer
#14
JOURNAL ARTICLE
Morena Shkodra, Matthew Mulvey, Marie Fallon, Cinzia Brunelli, Ernesto Zecca, Paola Bracchi, Mariangela Caputo, Giacomo Massa, Silvia Lo Dico, Roman Rolke, Stein Kaasa, Augusto Caraceni
INTRODUCTION: Better diagnosis and treatment of neuropathic cancer pain (NcP) remains an unmet clinical need. The EAPC/IASP algorithm was specifically designed for NcP diagnosis; yet, to date, there is no information on its application and accuracy. OBJECTIVES: Our aim was to determine the accuracy of the EAPC/IASP algorithm compared with the Neuropathic Special Interest Group grading system (gold standard) and to describe patients' sensory profile with quantitative sensory testing (QST)...
April 2024: Pain Reports
https://read.qxmd.com/read/38354391/do-we-still-need-illumina-sequencing-data-evaluating-oxford-nanopore-technologies-r10-4-1-flow-cells-and-the-rapid-v14-library-prep-kit-for-gram-negative-bacteria-whole-genome-assemblies
#15
JOURNAL ARTICLE
Nicole A Lerminiaux, Ken Fakharuddin, Michael Mulvey, Laura Mataseje
The best whole genome assemblies are currently built from a combination of highly accurate short-read sequencing data and long-read sequencing data that can bridge repetitive and problematic regions. Oxford Nanopore Technologies (ONT) produce long-read sequencing platforms and they are continually improving their technology to obtain higher-quality read data that is approaching the quality obtained from short-read platforms such as Illumina. As these innovations continue, we evaluated how much ONT read coverage produced by the Rapid Barcoding Kit v14 (SQK-RBK114) is necessary to generate high-quality hybrid and long-read-only genome assemblies for a panel of carbapenemase-producing Enterobacterales bacterial isolates...
February 14, 2024: Canadian Journal of Microbiology
https://read.qxmd.com/read/38285112/can-illness-representations-be-used-to-understand-pain-experienced-in-breast-cancer-survivorship-a-cross-sectional-study
#16
JOURNAL ARTICLE
Lewis Langford, Gary Latchford, Matt Mulvey
BACKGROUND: Chronic pain is a recognised long-term consequence associated with breast cancer and its treatment; however, it is often underdiagnosed and undertreated. This study aims to explore the associations between illness representations, chronic cancer pain, and HRQoL in women who have survived breast cancer. DESIGN AND METHODS: A cross-sectional online survey design was used. Data from 182 women who participated in the survey were analysed. RESULTS: Chronic cancer pain was reported by 66% of respondents...
January 29, 2024: Journal of Cancer Survivorship: Research and Practice
https://read.qxmd.com/read/38265923/supportive-care-for-cancer-patients-via-telehealth-breaking-bad-news-and-providing-palliative-care-virtually
#17
JOURNAL ARTICLE
Tara E Soumerai, Therese M Mulvey, Vicki A Jackson, Inga T Lennes
Delivering oncologic care via telemedicine has presented a unique set of benefits and challenges. Discussions of sensitive topics between patients and providers can be difficult on a virtual platform. Although it was imperative to utilize telemedicine to keep cancer patients safe during the height of the pandemic, its continued use in the postvaccination era has provided important conveniences to both providers and patients. In the case of breaking bad news and end-of-life discussions, however, in-person care has remained the overwhelming preference of both groups...
January 2024: Cancer Journal
https://read.qxmd.com/read/38239760/how-college-students-in-the-united-states-make-sense-of-examples-of-gender-and-intersectional-microaggressions-in-classroom-settings
#18
JOURNAL ARTICLE
Allegra J Midgette, Grace Anderson, Sara Geiger, Rogerlyne Slawon, Brock Derrow, Kelly Lynn Mulvey
Women and racially minoritized college students report frequent experiences of being targets of gender and race-based microaggressions in the classroom context. However, while much research has focused on reports of experiences by targets, less is known about how observers would evaluate and make sense of these microaggressive experiences. Thus the present study used vignettes based on real-life situations to ascertain how 272 college students (76% White, 52% ciswomen) in the United States interpreted gender-based and intersectional microaggressions occurring in the classroom...
December 2023: Journal of Social and Personal Relationships
https://read.qxmd.com/read/38239701/cryoem-reveals-the-complex-self-assembly-of-a-chemically-driven-disulfide-hydrogel
#19
JOURNAL ARTICLE
Paul Joshua Hurst, Justin T Mulvey, Rebecca A Bone, Serxho Selmani, Redford F Hudson, Zhibin Guan, Jason R Green, Joseph P Patterson
Inspired by the adaptability of biological materials, a variety of synthetic, chemically driven self-assembly processes have been developed that result in the transient formation of supramolecular structures. These structures form through two simultaneous reactions, forward and backward, which generate and consume a molecule that undergoes self-assembly. The dynamics of these assembly processes have been shown to differ from conventional thermodynamically stable molecular assemblies. However, the evolution of nanoscale morphologies in chemically driven self-assembly and how they compare to conventional assemblies has not been resolved...
January 17, 2024: Chemical Science
https://read.qxmd.com/read/38217796/impact-of-the-covid-19-pandemic-on-people-living-with-rheumatoid-arthritis-experiences-and-preferences-in-accessing-healthcare-across-five%C3%A2-countries
#20
JOURNAL ARTICLE
Alain Saraux, Licia Maria Henrique da Mota, Sanjay Dixit, Allan Gibofsky, Tsukasa Matsubara, Amy Mulvey, Cheryl Koehn, Mahta Mortezavi, Michelle Segovia, Meriem Kessouri
INTRODUCTION: The global coronavirus 2019 (COVID-19) pandemic created many challenges in healthcare provision. This study aimed to evaluate the global impact of the COVID-19 pandemic on people living with rheumatoid arthritis (RA). METHODS: The RA Narrative COVID-19 survey was conducted online among people with RA who resided in Brazil, Canada, France, Japan, and the US from August to September 2021. The survey examined disease management, healthcare access and experiences, and participant preferences for interactions with their doctor...
January 13, 2024: Rheumatology and Therapy
keyword
keyword
49522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.