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https://www.readbyqxmd.com/read/28090789/escalating-mental-health-care-in-pediatric-emergency-departments
#1
Steven C Rogers, Christine H Mulvey, Susan Divietro, Jesse Sturm
No abstract text is available yet for this article.
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28087946/invasion-of-host-cells-and-tissues-by-uropathogenic-bacteria
#2
Adam J Lewis, Amanda C Richards, Matthew A Mulvey
Within the mammalian urinary tract uropathogenic bacteria face many challenges, including the shearing flow of urine, numerous antibacterial molecules, the bactericidal effects of phagocytes, and a scarcity of nutrients. These problems may be circumvented in part by the ability of uropathogenic Escherichia coli and several other uropathogens to invade the epithelial cells that line the urinary tract. By entering host cells, uropathogens can gain access to additional nutrients and protection from both host defenses and antibiotic treatments...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28046940/su-f-r-03-classification-of-glioblastoma-multiforme-molecular-subtypes-using-three-dimensional-multi-modal-mr-imaging-features
#3
M Mulvey, S Muhyadeen, U Sinha
PURPOSE: Positive patient outcomes with the use of aggressive concurrent chemoradiotherapy have been shown for classical and mesenchymal glioblastoma multiformae (GBM) subtypes, while not having the same positive effect for patients with neural and proneural subtypes. Quantitative MR Imaging features from multimodal MRI have been recently explored for GBM subtype classification with some promising results. We have integrated 3D textural and moment invariant features to investigate if these will strengthen the association between glioblastoma MR image features and genomic markers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029297/capturing-high-value-cancer-care-in-the-wild
#4
Therese Marie Mulvey, Jeffrey Peppercorn
No abstract text is available yet for this article.
December 28, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28018876/frequency-of-mcr-1-mediated-colistin-resistance-among-escherichia-coli-clinical-isolates-obtained-from-patients-in-canadian-hospitals-canward-2008-2015
#5
Andrew Walkty, James A Karlowsky, Heather J Adam, Philippe Lagacé-Wiens, Melanie Baxter, Michael R Mulvey, Melissa McCracken, Susan M Poutanen, Diane Roscoe, George G Zhanel
BACKGROUND: Colistin is often used as an antimicrobial of last resort for the treatment of infections caused by multidrug-resistant gram-negative bacilli. In 2015, plasmid-mediated colistin resistance in Escherichia coli due to MCR-1 was described. The purpose of this study was to evaluate the frequency of colistin resistance among E. coli clinical isolates obtained from patients in Canadian hospitals as part of the Canadian Ward Surveillance Study (CANWARD) and to determine how often the mcr-1 gene is detected among the colistin-resistant subset...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28000994/lithium-dihydropyridine-dehydrogenation-catalysis-a-group%C3%A2-1-approach-to-the-cyclization-of-diamine-boranes
#6
Ross McLellan, Alan R Kennedy, Samantha A Orr, Stuart D Robertson, Robert E Mulvey
In reactions restricted previously to a ruthenium catalyst, a 1-lithium-2-alkyl-1,2-dihydropyridine complex is shown to be a competitive alternative dehydrogenation catalyst for the transformation of diamine boranes into cyclic 1,3,2-diazaborolidines, which can in turn be smoothly arylated in good yields. This study established the conditions and solvent dependence of the catalysis through NMR monitoring, with mechanistic insight provided by NMR (including DOSY) experiments and X-ray crystallographic studies of several model lithio intermediates...
December 21, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27989537/delayed-cardiac-tamponade-a-rare-but-life-threatening-complication-of-catheter-ablation
#7
Elizabeth Yetter, Jared Brazg, Diane Del Valle, Laura Mulvey, Eitan Dickman
Delayed cardiac tamponade (DCT) is a rare and life-threatening complication of catheter ablation performed as a treatment of atrial fibrillation, with few cases described in the medical literature. We present the case of a 57year-old man presenting with DCT 61days following a catheter ablation procedure. To the best of our knowledge, this is the most delayed case of cardiac tamponade (CT) following catheter ablation described in the literature. We also discuss the importance of point of care ultrasound (POCUS) in the diagnosis and treatment of CT...
November 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27890457/the-role-of-whole-genome-sequencing-in-antimicrobial-susceptibility-testing-of-bacteria-report-from-the-eucast-subcommittee
#8
REVIEW
M J Ellington, O Ekelund, F M Aarestrup, R Canton, M Doumith, C Giske, H Grundman, H Hasman, M T G Holden, K L Hopkins, J Iredell, G Kahlmeter, C U Köser, A MacGowan, D Mevius, M Mulvey, T Naas, T Peto, J-M Rolain, Ø Samuelsen, N Woodford
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility from a single assay. The European Committee on Antimicrobial Susceptibility Testing established a subcommittee to review the current development status of WGS for bacterial antimicrobial susceptibility testing (AST). The published evidence for using WGS as a tool to infer antimicrobial susceptibility accurately is currently either poor or non-existent and the evidence / knowledge base requires significant expansion. The primary comparators for assessing genotypic-phenotypic concordance from WGS data should be changed to epidemiological cut-off values in order to improve differentiation of wild-type from non-wild-type isolates (harbouring an acquired resistance)...
November 23, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27884691/aapt-diagnostic-criteria-for-chronic-cancer-pain-conditions
#9
REVIEW
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy initiative worked to develop the characteristics of an optimal diagnostic system...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27820834/ccl2-ccr2-regulates-the-tumor-microenvironment-in-her-2-neu-driven-mammary-carcinomas-in-mice
#10
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization...
2016: PloS One
https://www.readbyqxmd.com/read/27737442/association-of-clinical-risk-factors-and-postoperative-complications-with-unplanned-hospital-readmission-after-head-and-neck-cancer-surgery
#11
Andrés M Bur, Jason A Brant, Carolyn L Mulvey, Elizabeth A Nicolli, Robert M Brody, John P Fischer, Steven B Cannady, Jason G Newman
Importance: Unplanned hospital readmission is costly and in recent years has become a focus of health care legislation intended to reduce health care expenditures. Greater understanding of which perioperative complications are associated with hospital readmission after surgery for head and neck cancer is needed to reduce unplanned readmissions. Objective: To determine which clinical risk factors and complications are associated with 30-day unplanned readmission after surgery for malignant neoplasms of the head and neck...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27722632/revealing-the-remarkable-structural-diversity-of-the-alkali-metal-transfer-agents-of-the-trans-calix-2-benzene-2-pyrrolide-ligand
#12
M Ángeles Fuentes, Antonio J Martínez-Martínez, Alan R Kennedy, Robert E Mulvey
Excellent reagents for transferring their heterocalix[4]arene ligand to f-block organometallic complexes, lithium, sodium and potassium trans-calix[2]benzene[2]pyrrolides have been found to adopt a fascinating series of structures in their own right.
October 6, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27684393/race-based-humor-and-peer-group-dynamics-in-adolescence-bystander-intervention-and-social-exclusion
#13
Kelly Lynn Mulvey, Sally B Palmer, Dominic Abrams
Adolescents' evaluations of discriminatory race-based humor and their expectations about peer responses to discrimination were investigated in 8th- (Mage  = 13.80) and 10th-grade (Mage  = 16.11) primarily European-American participants (N = 256). Older adolescents judged race-based humor as more acceptable than did younger adolescents and were less likely to expect peer intervention. Participants who rejected discrimination were more likely to reference welfare/rights and prejudice and to anticipate that peers would intervene...
September 2016: Child Development
https://www.readbyqxmd.com/read/27647741/transforming-litmp-lithiation-of-challenging-diazines-through-gallium-alkyl-trans-metal-trapping
#14
Marina Uzelac, Alan R Kennedy, Eva Hevia, Robert E Mulvey
This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2 SiMe3 )3 , GaR3 ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as through the N-S heterocycle benzothiazole. The metallo-activated complexes of all of these compounds were isolated and structurally defined...
October 10, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27626624/opioid-prescribing-for-patients-with-cancer-in-the-last-year-of-life-a-longitudinal-population-cohort-study
#15
Lucy Ziegler, Matthew Mulvey, Alison Blenkinsopp, Duncan Petty, Michael I Bennett
We linked UK cancer registry data with the corresponding electronic primary care medical records of 6080 patients who died of cancer over a 7-year period in a large United Kingdom city. We extracted all prescriptions for analgesics issued to each patient in the linked cohort during the 12 months before death and analysed the extent and duration of strong opioid treatment with clinical and patient characteristics. Strong opioids were prescribed for 48% of patients in the last year of life. Median interval between first prescription of a strong opioid and death was 9 weeks (interquartile range 3-23)...
November 2016: Pain
https://www.readbyqxmd.com/read/27609929/complete-genome-sequences-of-neisseria-gonorrhoeae-with-coresistance-to-first-line-antimicrobials
#16
Amrita Bharat, Irene Martin, Walter Demczuk, Vanessa Allen, David Haldane, Linda Hoang, Michael R Mulvey
Neisseria gonorrhoeae strains with coresistance to the first-line antimicrobial treatments azithromycin and ceftriaxone are an emerging public health threat. Here, we present the complete genome sequences of three strains of N. gonorrhoeae, including one susceptible strain and two strains with coresistance to ceftriaxone and azithromycin.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27600052/results-from-the-canadian-nosocomial-infection-surveillance-program-on-carbapenemase-producing-enterobacteriaceae-2010-to-2014
#17
Laura F Mataseje, Kahina Abdesselam, Julie Vachon, Robyn Mitchel, Elizabeth Bryce, Diane Roscoe, David A Boyd, Joanne Embree, Kevin Katz, Pamela Kibsey, Andrew E Simor, Geoffrey Taylor, Nathalie Turgeon, Joanne Langley, Denise Gravel, Kanchana Amaratunga, Michael R Mulvey
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing globally; here we report on the investigation of CPE in Canada over a 5-year period. Participating acute care facilities across Canada submitted carbapenem-nonsusceptible Enterobacteriaceae from 1 January 2010 to 31 December 2014 to the National Microbiology Laboratory. All CPE were characterized by antimicrobial susceptibilities, pulsed-field gel electrophoresis, multilocus sequence typing, and plasmid restriction fragment length polymorphism analysis and had patient data collected using a standard questionnaire...
November 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27597651/disentangling-the-effect-of-dietary-restriction-on-mitochondrial-function-using-recombinant-inbred-mice
#18
Lorna Mulvey, William A Sands, Karine Salin, Amanda E Carr, Colin Selman
Dietary restriction (DR) extends lifespan and healthspan in many species, but precisely how it elicits its beneficial effects is unclear. We investigated the impact of DR on mitochondrial function within liver and skeletal muscle of female ILSXISS mice that exhibit strain-specific variation in lifespan under 40% DR. Strains TejJ89 (lifespan increased under DR), TejJ48 (lifespan unaffected by DR) and TejJ114 (lifespan decreased under DR) were studied following 10 months of 40% DR (13 months of age). Oxygen consumption rates (OCR) within isolated liver mitochondria were unaffected by DR in TejJ89 and TejJ48, but decreased by DR in TejJ114...
September 2, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27573676/structural-diversity-in-alkali-metal-and-alkali-metal-magnesiate-chemistry-of-the-bulky-2-6-diisopropyl-n-trimethylsilyl-anilino-ligand
#19
M Ángeles Fuentes, Andoni Zabala, Alan R Kennedy, Robert E Mulvey
Bulky amido ligands are precious in s-block chemistry, since they can implant complementary strong basic and weak nucleophilic properties within compounds. Recent work has shown the pivotal importance of the base structure with enhancement of basicity and extraordinary regioselectivities possible for cyclic alkali metal magnesiates containing mixed n-butyl/amido ligand sets. This work advances alkali metal and alkali metal magnesiate chemistry of the bulky arylsilyl amido ligand [N(SiMe3 )(Dipp)](-) (Dipp=2,6-iPr2 -C6 H3 )...
October 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27468684/deconvoluting-hepatic-processing-of-carbon-nanotubes
#20
Simone Alidori, Robert L Bowman, Dmitry Yarilin, Yevgeniy Romin, Afsar Barlas, J Justin Mulvey, Sho Fujisawa, Ke Xu, Alessandro Ruggiero, Vladimir Riabov, Daniel L J Thorek, Hans David S Ulmert, Elliott J Brea, Katja Behling, Julia Kzhyshkowska, Katia Manova-Todorova, David A Scheinberg, Michael R McDevitt
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination...
2016: Nature Communications
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