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Matthew J Ellington, Oskar Ekelund, Frank M Aarestrup, Rafael Canton, Michel Doumith, Christian Giske, Hajo Grundman, Henrik Hasman, Matthew Holden, Katie L Hopkins, Jon Iredell, Gunnar Kahlmeter, Claudio U Köser, Alasdair MacGowan, Dik Mevius, Mike Mulvey, Thierry Naas, Tim Peto, Jean-Marc Rolain, Ørjan Samuelsen, Neil Woodford
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility from a single assay. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) established a subcommittee to review the current development status of WGS for bacterial antimicrobial susceptibility testing (AST). The published evidence for using WGS as a tool to infer antimicrobial susceptibility accurately is currently either poor or non-existent and the evidence / knowledge base requires significant expansion...
November 23, 2016: Clinical Microbiology and Infection
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative worked to develop the characteristics of an optimal diagnostic system...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization...
2016: PloS One
Andrés M Bur, Jason A Brant, Carolyn L Mulvey, Elizabeth A Nicolli, Robert M Brody, John P Fischer, Steven B Cannady, Jason G Newman
Importance: Unplanned hospital readmission is costly and in recent years has become a focus of health care legislation intended to reduce health care expenditures. Greater understanding of which perioperative complications are associated with hospital readmission after surgery for head and neck cancer is needed to reduce unplanned readmissions. Objective: To determine which clinical risk factors and complications are associated with 30-day unplanned readmission after surgery for malignant neoplasms of the head and neck...
October 13, 2016: JAMA Otolaryngology—Head & Neck Surgery
M Ángeles Fuentes, Antonio J Martínez-Martínez, Alan R Kennedy, Robert E Mulvey
Excellent reagents for transferring their heterocalix[4]arene ligand to f-block organometallic complexes, lithium, sodium and potassium trans-calix[2]benzene[2]pyrrolides have been found to adopt a fascinating series of structures in their own right.
October 6, 2016: Chemical Communications: Chem Comm
Kelly Lynn Mulvey, Sally B Palmer, Dominic Abrams
Adolescents' evaluations of discriminatory race-based humor and their expectations about peer responses to discrimination were investigated in 8th- (Mage  = 13.80) and 10th-grade (Mage  = 16.11) primarily European-American participants (N = 256). Older adolescents judged race-based humor as more acceptable than did younger adolescents and were less likely to expect peer intervention. Participants who rejected discrimination were more likely to reference welfare/rights and prejudice and to anticipate that peers would intervene...
September 2016: Child Development
Marina Uzelac, Alan R Kennedy, Eva Hevia, Robert E Mulvey
This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2 SiMe3 )3 , GaR3 ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as through the N-S heterocycle benzothiazole. The metallo-activated complexes of all of these compounds were isolated and structurally defined...
October 10, 2016: Angewandte Chemie
Lucy Ziegler, Matthew Mulvey, Alison Blenkinsopp, Duncan Petty, Michael I Bennett
We linked UK cancer registry data with the corresponding electronic primary care medical records of 6080 patients who died of cancer over a 7-year period in a large United Kingdom city. We extracted all prescriptions for analgesics issued to each patient in the linked cohort during the 12 months before death and analysed the extent and duration of strong opioid treatment with clinical and patient characteristics. Strong opioids were prescribed for 48% of patients in the last year of life. Median interval between first prescription of a strong opioid and death was 9 weeks (interquartile range 3-23)...
November 2016: Pain
Amrita Bharat, Irene Martin, Walter Demczuk, Vanessa Allen, David Haldane, Linda Hoang, Michael R Mulvey
Neisseria gonorrhoeae strains with coresistance to the first-line antimicrobial treatments azithromycin and ceftriaxone are an emerging public health threat. Here, we present the complete genome sequences of three strains of N. gonorrhoeae, including one susceptible strain and two strains with coresistance to ceftriaxone and azithromycin.
2016: Genome Announcements
Laura F Mataseje, Kahina Abdesselam, Julie Vachon, Robyn Mitchel, Elizabeth Bryce, Diane Roscoe, David A Boyd, Joanne Embree, Kevin Katz, Pamela Kibsey, Andrew E Simor, Geoffrey Taylor, Nathalie Turgeon, Joanne Langley, Denise Gravel, Kanchana Amaratunga, Michael R Mulvey
Carbapenemase producing Enterobacteriaceae (CPE) is increasing globally; here we report on the investigation of CPE in Canada over a five-year period. Participating acute care facilities across Canada submitted carbapenem non-susceptible Enterobacteriaceae from January 1 2010 to December 31 2014 to the National Microbiology Laboratory. All CPEs were characterized by antimicrobial susceptibilities, pulsed-field gel electrophoresis, multi-locus sequence typing and plasmid restriction fragment length polymorphism analysis and had patient data collected using a standard questionnaire...
September 6, 2016: Antimicrobial Agents and Chemotherapy
Lorna Mulvey, William A Sands, Karine Salin, Amanda E Carr, Colin Selman
Dietary restriction (DR) extends lifespan and healthspan in many species, but precisely how it elicits its beneficial effects is unclear. We investigated the impact of DR on mitochondrial function within liver and skeletal muscle of female ILSXISS mice that exhibit strain-specific variation in lifespan under 40% DR. Strains TejJ89 (lifespan increased under DR), TejJ48 (lifespan unaffected by DR) and TejJ114 (lifespan decreased under DR) were studied following 10 months of 40% DR (13 months of age). Oxygen consumption rates (OCR) within isolated liver mitochondria were unaffected by DR in TejJ89 and TejJ48, but decreased by DR in TejJ114...
September 2, 2016: Molecular and Cellular Endocrinology
M Ángeles Fuentes, Andoni Zabala, Alan R Kennedy, Robert E Mulvey
Bulky amido ligands are precious in s-block chemistry, since they can implant complementary strong basic and weak nucleophilic properties within compounds. Recent work has shown the pivotal importance of the base structure with enhancement of basicity and extraordinary regioselectivities possible for cyclic alkali metal magnesiates containing mixed n-butyl/amido ligand sets. This work advances alkali metal and alkali metal magnesiate chemistry of the bulky arylsilyl amido ligand [N(SiMe3 )(Dipp)](-) (Dipp=2,6-iPr2 -C6 H3 )...
October 10, 2016: Chemistry: a European Journal
Simone Alidori, Robert L Bowman, Dmitry Yarilin, Yevgeniy Romin, Afsar Barlas, J Justin Mulvey, Sho Fujisawa, Ke Xu, Alessandro Ruggiero, Vladimir Riabov, Daniel L J Thorek, Hans David S Ulmert, Elliott J Brea, Katja Behling, Julia Kzhyshkowska, Katia Manova-Todorova, David A Scheinberg, Michael R McDevitt
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination...
2016: Nature Communications
Amanda M Fanniff, Carol A Schubert, Edward P Mulvey, Anne-Marie R Iselin, Alex R Piquero
Juveniles who have committed sexual offenses are subject to specialized treatment and policies based on their assumed unique dangerousness, despite contradictory evidence. Limited information is available regarding risk factors and their relationships to outcomes in this population. The comparative frequency and predictive utility of empirically supported risk factors for general delinquency were examined using data from the Pathways to Desistance study. Adolescent males who committed sexual offenses (n = 127) were compared to adolescent males who committed non-sexual offenses (n = 1021)...
July 12, 2016: Journal of Youth and Adolescence
Dong Wang, Fiona B Mulvey, Jeff B Pelz, Kenneth Holmqvist
The precision of an eye-tracker is critical to the correct identification of eye movements and their properties. To measure a system's precision, artificial eyes (AEs) are often used, to exclude eye movements influencing the measurements. A possible issue, however, is that it is virtually impossible to construct AEs with sufficient complexity to fully represent the human eye. To examine the consequences of this limitation, we tested currently used AEs from three manufacturers of eye-trackers and compared them to a more complex model, using 12 commercial eye-trackers...
July 6, 2016: Behavior Research Methods
Agatha N Jassem, Natalie Prystajecky, Fawziah Marra, Pamela Kibsey, Kennard Tan, Patricia Umlandt, Loretta Janz, Sylvie Champagne, Bruce Gamage, George R Golding, Michael R Mulvey, Bonnie Henry, Linda M N Hoang
Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008) and one Island Health hospital laboratory (2013) were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Edward P Mulvey, Carol A Schubert, Lindsey Pitzer, Samuel Hawes, Alex Piquero, Stephanie Cardwell
PURPOSE: We examine whether and how much risk/need indicators change over time in a sample of serious adolescent offenders and whether changes in risk are related to self-reported and official record reports of offending in the year following assessment. METHODS: Growth curve and multilevel mixed-effects models are used to examine change through age 18 in a sample of 1,354 serious adolescent offenders participating in the Pathways to Desistance Study. RESULTS: Three primary findings emerge: 1) Compared to the baseline assessment, overall risk/need scores decrease over time...
June 2016: Journal of Criminal Justice
Stephanie Kennedy, Matthew Caldwell, Torre Bydlon, Christine Mulvey, Jenna Mueller, Lee Wilke, William Barry, Nimmi Ramanujam, Joseph Geradts
No abstract text is available yet for this article.
June 1, 2016: Journal of Biomedical Optics
Amelia E Barber, Brittany A Fleming, Matthew A Mulvey
In individuals with sepsis, the infecting microbes are commonly viewed as generic inducers of inflammation while the host background is considered the primary variable affecting disease progression and outcome. To study the effects of bacterial strain differences on the maladaptive immune responses that are induced during sepsis, we employed a novel zebrafish embryo infection model using extraintestinal pathogenic Escherichia coli (ExPEC) isolates. These genetically diverse pathogens are a leading cause of sepsis and are becoming increasingly dangerous because of the rise of multidrug-resistant strains...
March 2016: MSphere
Lowell E Schnipper, Nancy E Davidson, Dana S Wollins, Douglas W Blayney, Adam P Dicker, Patricia A Ganz, J Russell Hoverman, Robert Langdon, Gary H Lyman, Neal J Meropol, Therese Mulvey, Lee Newcomer, Jeffrey Peppercorn, Blase Polite, Derek Raghavan, Gregory Rossi, Leonard Saltz, Deborah Schrag, Thomas J Smith, Peter P Yu, Clifford A Hudis, Julie M Vose, Richard L Schilsky
No abstract text is available yet for this article.
August 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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